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The Crosstalk Between the Bone and the Immune System: Osteoimmunology

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The Crosstalk Between the Bone and the Immune System: Osteoimmunology Clinical and Developmental Immunology The Crosstalk between the Bone and the Immune System: Osteoimmunology Guest Editors: Giacomina Brunetti, Giorgio Mori, Patrizia D’Amelio, and Roberta Faccio The Crosstalk between the Bone and the Immune System: Osteoimmunology Clinical and Developmental Immunology The Crosstalk between the Bone and the Immune System: Osteoimmunology Guest Editors: Giacomina Brunetti, Giorgio Mori, Patrizia D’Amelio, and Roberta Faccio Copyright © 2013 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Clinical and Developmentalology.” Immun All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board B. Dicky Akanmori, Ghana H. Inoko, Japan Ira H. Pastan, USA Robert Baughman, USA David Kaplan, USA B. Prakken, The Netherlands Stuart Berzins, Australia W. Kast, USA Nima Rezaei, Iran Bengt Bjorksten, Sweden Taro Kawai, Japan Clelia M. Riera, Argentina K. Blaser, Switzerland M. H. Kershaw, Australia Luigina Romani, Italy Federico Bussolino, Italy Hiroshi Kiyono, Japan Aurelia Rughetti, Italy Nitya G. Chakraborty, USA Shigeo Koido, Japan Takami Sato, USA Robert B. Clark, USA Guido Kroemer, France Senthamil R. Selvan, USA Mario Clerici, Italy H. Kim Lyerly, USA Naohiro Seo, Japan Edward P. Cohen, USA Enrico Maggi, Italy E. M. Shevach, USA Robert E. Cone, USA Stuart Mannering, Australia George B. Stefano, USA Nathalie Cools, Belgium Eiji Matsuura, Japan Trina J. Stewart, Australia Mark J. Dobrzanski, USA C. M. Melief, The Netherlands Helen Su, USA Nejat Egilmez, USA Jiri Mestecky, USA Jacek Tabarkiewicz, Poland Eyad Elkord, UK C. Morimoto, Japan Ban-Hock Toh, Australia Steven E. Finkelstein, USA Hiroshi Nakajima, Japan J. F. Urban, USA Luca Gattinoni, USA T. Nakayama, Japan Y. Van Kooyk, The Netherlands David E. Gilham, UK H. Nijman, The Netherlands Xiao-Feng Yang, USA Ronald B. Herberman, USA Paola Nistico, Italy Y. Yoshikai, Japan D. Craig Hooper, USA Graham Ogg, UK Qiang Zhang, USA Eung Jun Im, USA G. Opdenakker, Belgium Contents The Crosstalk between the Bone and the Immune System: Osteoimmunology,GiacominaBrunetti, Giorgio Mori, Patrizia D’Amelio, and Roberta Faccio Volume 2013, Article ID 617319, 2 pages Th17 and Treg Cells in Bone Related Diseases, Min Wang, Tian Tian, Shuang Yu, Na He, and Daoxin Ma Volume 2013, Article ID 203705, 10 pages The Interplay between the Bone and the Immune System, Giorgio Mori, Patrizia D’Amelio, Roberta Faccio, and Giacomina Brunetti Volume 2013, Article ID 720504, 16 pages Bone Effects of Biologic Drugs in Rheumatoid Arthritis, Addolorata Corrado, Anna Neve, Nicola Maruotti, and Francesco Paolo Cantatore Volume 2013, Article ID 945945, 7 pages Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune Systems, Zachary S. Buchwald and Rajeev Aurora Volume 2013, Article ID 429373, 9 pages FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis, Graziana Colaianni, Concetta Cuscito, and Silvia Colucci Volume 2013, Article ID 382698, 6 pages Cellular Mechanisms of Multiple Myeloma Bone Disease, Angela Oranger, Claudia Carbone, Maddalena Izzo, and Maria Grano Volume 2013, Article ID 289458, 11 pages Postmenopausal Osteoporosis: The Role of Immune System Cells, Maria Felicia Faienza, Annamaria Ventura, Flaviana Marzano, and Luciano Cavallo Volume 2013, Article ID 575936, 6 pages Immunological Reaction in TNF--Mediated Osteoclast Formation and Bone Resorption In Vitro and In Vivo, Hideki Kitaura, Keisuke Kimura, Masahiko Ishida, Haruka Kohara, Masako Yoshimatsu, and Teruko Takano-Yamamoto Volume 2013, Article ID 181849, 8 pages Periodontal Disease: Linking the Primary Inflammation to Bone Loss, Adriana Di Benedetto, Isabella Gigante, Silvia Colucci, and Maria Grano Volume 2013, Article ID 503754, 7 pages RANKL Cytokine: From Pioneer of the Osteoimmunology Era to Cure for a Rare Disease, Nadia Lo Iacono, Alessandra Pangrazio, Mario Abinun, Robbert Bredius, Marco Zecca, Harry C. Blair, Paolo Vezzoni, Anna Villa, and Cristina Sobacchi Volume 2013, Article ID 412768, 9 pages Interaction among Cells of Bone, Immune System, and Solid Tumors Leads to Bone Metastases, Ilaria Roato Volume 2013, Article ID 315024, 7 pages NFAT Signaling in Osteoblasts Regulates the Hematopoietic Niche in the Bone Microenvironment, Cheryl L. Sesler and Majd Zayzafoon Volume 2013, Article ID 107321, 11 pages Potential Use of Bisphosphonates in Invasive Extramammary Paget’s Disease: An Immunohistochemical Investigation, Taku Fujimura, Sadanori Furudate, Yumi Kambayashi, and Setsuya Aiba Volume 2013, Article ID 164982, 6 pages Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2013, Article ID 617319, 2 pages http://dx.doi.org/10.1155/2013/617319 Editorial The Crosstalk between the Bone and the Immune System: Osteoimmunology Giacomina Brunetti,1 Giorgio Mori,2 Patrizia D’Amelio,3 and Roberta Faccio4 1 Department of Basic Medical Sciences, Neuroscience and Sense Organs, Section of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy 2 Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy 3 Department of Medical Sciences, University of Torino, 10126 Torino, Italy 4 Department of Orthopedics, Washington University School of Medicine, St. Louis, MO 63110, USA Correspondence should be addressed to Giacomina Brunetti; [email protected] Received 31 July 2013; Accepted 31 July 2013 Copyright © 2013 Giacomina Brunetti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Osteoimmunology is an interdisciplinary research field knowntoplayafundamentalroleduringosteoclastogenesis focused on the molecular understanding of the interplay in the context of inflammatory arthritis, as described by H. between the skeletal and immune systems. Recent reports Kitaura et al. Comprehensive reports detailing the interaction suggest that a large number of molecules affect both bone between bone and immune cells in the periodontal diseases and immune cells. Furthermore, it has been demonstrated and postmenopausal osteoporosis are reported, respectively, that immune cells express molecules modulating bone cell by A. Di Benedetto et al. and M. F. Faienza et al. The development and bone is known to provide important signal involvement of T cells in bone metastatic solid tumors has to the hematopoietic and immune cells, which develop in the beencarefullyreviewedbyI.Roato.Immunecellcontribution bone marrow and then migrate to peripheral organs. in multiple myeloma bone disease is well described by A. Alltheseconceptsarewellrepresentedinthisspecial Oranger et al. Understanding how bone and immune cells issue, starting from a large overview of bone cell differenti- mutually interact with each other can give rise to new ation, followed by the general mechanisms highlighting the therapeutical targets as described by A. Corrado et al. in interaction between bone and immune cells described by G. the context of rheumatoid arthritis. Moreover, T. Fujimura Mori et al. The effect of the numerous T-cell subsets on bone et al. demonstrated that, in invasive extramammary Paget’s cells is very complex. In particular, a clear overview on Th17 disease, the administration of bisphosphonates, privileged and Treg and their involvement in bone diseases is presented antiresorptive drugs, has also an immunosuppressive role in by M. Wang et al., whereas a more detailed description of the addition to blocking osteoclast activity. negative regulatory feedback loop between osteoclasts and Recent findings suggested that immune cells are critical CD8+ T cells that contributes to homeostasis of both the mediators of the effect of different hormones on bone skeletal and immune systems is provided by Z. S. Buchwald cells. In particular, G. Colaianni et al. analyzed the Pitu- and R. Aurora. itary/Immune/Bone Axis, highlighting the effect immune The first identified pioneer cytokine regulating both bone cell-mediated of hormones such as FSH and TSH on bone and immune systems is RANKL, revised by N. Lo Iacono et remodeling.Finally,furthersustainingtheroleofbonecells al. The authors also report that a genetic defect impairing on the regulation of haematopoiesis, C. L. Sesler and M. RANKL function leads to a peculiar form of an invalidating Zayzafoon demonstrated that the inhibition of NFAT activa- rare bone disease, named autosomal recessive osteopetrosis. tion in osteoblasts increases bone formation while decreasing In addition to RANKL, TNF-alpha is another cytokine B-cell development in the bone marrow microenvironment. 2 Clinical and Developmental Immunology These manuscripts represent an exciting and insightful snapshot of current research on osteoimmunology. State-of- the-art and emerging future topics are highlighted in this special issue, which may help to advance the present research on the crosstalk between bone and immune cells. Giacomina Brunetti Giorgio Mori Patrizia D’Amelio Roberta Faccio Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2013, Article ID 203705, 10 pages http://dx.doi.org/10.1155/2013/203705 Review Article Th17 and Treg Cells in Bone Related Diseases Min Wang, Tian Tian,
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