September 2, 2014 u vol. 111 u no. 35 u 12569–12954

Cover image: Pictured are representations of the orbits and relative physical sizes of 1,475 extrasolar planet candidates discovered by NASA’s Kepler mission since 2009, including an excerpt of the 589 systems with two or more transiting planet candidates. More than half of the planet candidates shown have been statistically confirmed as true planets. The Exoplanets Special Feature, appearing in this issue, presents recent findings regarding the diversity of exoplanet sizes, compositions, and orbital distances, as well as the conditions likely to support life on exoplanets and potential methods for remotely detecting evidence of biological activity. See the Introduction to the Special Feature by Adam S. Burrows and Geoffrey W. Marcy on pages 12599–12600. Image courtesy of Daniel Fabrycky (University of Chicago, Chicago). From the Cover

12599 Comparative exoplanetology 12722 Refilling drug delivery depots 12799 Biofilm fragmentation in stream networks 12877 Oscillation of bacterial chromosomes

Contents SCIENCE AND CULTURE—How science intersects with culture 12571 Science and Culture: Representing Feynman Robert Frederick THIS WEEK IN PNAS

12569 In This Issue QNAS

LETTERS (ONLINE ONLY) 12572 QnAs with Patricia Kuhl Prashant Nair E3581 Errors in the Brown et al. critical reanalysis See Inaugural Article on page 11238 in issue 31 of Steven W. Cole and Barbara L. Fredrickson volume 111 E3582 No evidence for sample contamination or diet offset for pre-Columbian chicken dates from El Arenal Nancy Beavan RETROSPECTIVE E3583 No evidence against Polynesian dispersal of chickens to pre-Columbian South America 12574 Walter Jakob Gehring: A master of developmental Alice A. Storey and Elizabeth A. Matisoo-Smith biology E3584 Statistical flaws undermine pre-Columbian Markus Affolter and Kurt Wüthrich chicken debate David Bryant E3585 Reply to Beavan, Bryant, and Storey and Matisoo-Smith: COMMENTARIES Ancestral Polynesian “D” haplotypes reflect authentic Pacific chicken lineages Vicki A. Thomson, Ophélie Lebrasseur, Jeremy J. 12576 Reconsidering the phylogenetic utility of miRNA Austin, Terry L. Hunt, David A. Burney, Tim Denham, in animals Nicolas J. Rawlence, Jamie R. Wood, Jaime Gongora, Casey W. Dunn Linus Girdland Flink, Anna Linderholm, Keith Dobney, See companion article on page E3659 Greger Larson, and Alan Cooper 12578 PIP5K1α inhibition as a therapeutic strategy for prostate cancer Justin M. Drake and Jiaoti Huang Free online through the PNAS open access option. See companion article on page E3689

PNAS u September 2, 2014 u vol. 111 u no. 35 u iii–viii Downloaded by guest on September 24, 2021 12580 Switching modes of chromosome dynamics in the 12628 Requirements and limits for life in the context bacterial cell cycle of exoplanets Barbara E. Funnell Christopher P. McKay See companion article on page 12877 12641 Remote life-detection criteria, habitable zone boundaries, and the frequency of Earth-like planets around M and late K stars James F. Kasting, Ravikumar Kopparapu, Ramses M. PNAS PLUS Ramirez, and Chester E. Harman 12655 Occurrence and core-envelope structure of 1–4× 12582 Significance Statements Earth-size planets around Sun-like stars Brief statements written by the authors about the significance of Geoffrey W. Marcy, Lauren M. Weiss, Erik A. their papers. Petigura, Howard Isaacson, Andrew W. Howard, and Lars A. Buchhave 12661 First light of the Gemini Planet Imager PERSPECTIVE Bruce Macintosh, James R. Graham, Patrick Ingraham, Quinn Konopacky, Christian Marois, Marshall Perrin, Lisa Poyneer, Brian Bauman, Travis Barman, Adam S. 12585 Natural selection drives the evolution of ant Burrows, Andrew Cardwell, Jeffrey Chilcote, Robert J. life cycles De Rosa, Daren Dillon, Rene Doyon, Jennifer Dunn, Edward O. Wilson and Martin A. Nowak Darren Erikson, Michael P. Fitzgerald, Donald Gavel, Stephen Goodsell, Markus Hartung, Pascale Hibon, Paul Kalas, James Larkin, Jerome Maire, Franck Marchis, Mark S. Marley, James McBride, Max INAUGURAL ARTICLE Millar-Blanchaer, Katie Morzinski, Andrew Norton, B. R. Oppenheimer, David Palmer, Jennifer Patience, Laurent Pueyo, Fredrik Rantakyro, Naru Sadakuni, 12591 Genetic and pharmacological reactivation of the Leslie Saddlemyer, Dmitry Savransky, Andrew Serio, mammalian inactive X chromosome Remi Soummer, Anand Sivaramakrishnan, Inseok Song, Sanchita Bhatnagar, Xiaochun Zhu, Jianhong Ou, Sandrine Thomas, J. Kent Wallace, Sloane Wiktorowicz, Ling Lin, Lynn Chamberlain, Lihua J. Zhu, and Schuyler Wolff Narendra Wajapeyee, and Michael R. Green

PHYSICAL SCIENCES EXOPLANETS SPECIAL FEATURE

APPLIED PHYSICAL SCIENCES INTRODUCTION E3587 Efficient biomass pretreatment using ionic liquids 12599 Exoplanets derived from lignin and hemicellulose Adam S. Burrows and Geoffrey W. Marcy Aaron M. Socha, Ramakrishnan Parthasarathi, Jian Shi, Sivakumar Pattathil, Dorian Whyte, Maxime Bergeron, Anthe George, Kim Tran, Vitalie Stavila, Sivasankari PERSPECTIVES Venkatachalam, Michael G. Hahn, Blake A. Simmons, 12601 Spectra as windows into exoplanet atmospheres and Seema Singh Adam S. Burrows E3624 Direct measurement of the dielectric polarization 12634 The future of spectroscopic life detection on properties of DNA exoplanets Ana Cuervo, Pablo D. Dans, José L. Carrascosa, Sara Seager Modesto Orozco, Gabriel Gomila, and Laura Fumagalli

12647 Exploring exoplanet populations with NASA’s 12667 Gyrification from constrained cortical expansion Kepler Mission Tuomas Tallinen, Jun Young Chung, John S. Biggins, Natalie M. Batalha and L. Mahadevan 12673 Electrostatics-driven shape transitions in soft shells Vikram Jadhao, Creighton K. Thomas, RESEARCH ARTICLES and Monica Olvera de la Cruz 12610 Secular chaos and its application to Mercury, hot Jupiters, and the organization of planetary 12679 Plasmonic nanoparticle scattering for color holograms systems Yunuen Montelongo, Jaime Oscar Tenorio-Pearl, Calum Yoram Lithwick and Yanqin Wu Williams, Shuang Zhang, William Ireland Milne, and Timothy David Wilkinson 12616 Architectures of planetary systems and implications for their formation ASTRONOMY Eric B. Ford 12610 Secular chaos and its application to Mercury, 12622 Structure of exoplanets hot Jupiters, and the organization of planetary David S. Spiegel, Jonathan J. Fortney, systems and Christophe Sotin Yoram Lithwick and Yanqin Wu

iv u www.pnas.org Downloaded by guest on September 24, 2021 12616 Architectures of planetary systems and implications ENVIRONMENTAL SCIENCES for their formation 12693 Submesoscale dispersion in the vicinity of the Eric B. Ford Deepwater Horizon spill 12622 Structure of exoplanets Andrew C. Poje, Tamay M. Özgökmen, Bruce L. David S. Spiegel, Jonathan J. Fortney, Lipphardt, Jr., Brian K. Haus, Edward H. Ryan, and Christophe Sotin Angelique C. Haza, Gregg A. Jacobs, A. J. H. M. Reniers, Maria Josefina Olascoaga, Guillaume Novelli, 12628 Requirements and limits for life in the context Annalisa Griffa, Francisco J. Beron-Vera, Shuyi S. of exoplanets Chen, Emanuel Coelho, Patrick J. Hogan, Albert D. Christopher P. McKay Kirwan, Jr., Helga S. Huntley, and Arthur J. Mariano 12641 Remote life-detection criteria, habitable zone 12728 Immunolocalization of skeletal matrix proteins in tissue boundaries, and the frequency of Earth-like and mineral of the coral Stylophora pistillata planets around M and late K stars Tali Mass, Jeana L. Drake, Esther C. Peters, Wenge Jiang, James F. Kasting, Ravikumar Kopparapu, Ramses M. and Paul G. Falkowski Ramirez, and Chester E. Harman

12661 First light of the Gemini Planet Imager PHYSICS Bruce Macintosh, James R. Graham, Patrick Ingraham, 12699 Reconstruction of scalar and vectorial components Quinn Konopacky, Christian Marois, Marshall Perrin, in X-ray dark-field tomography Lisa Poyneer, Brian Bauman, Travis Barman, Adam S. Florian L. Bayer, Shiyang Hu, Andreas Maier, Burrows, Andrew Cardwell, Jeffrey Chilcote, Robert J. Thomas Weber, Gisela Anton, Thilo Michel, De Rosa, Daren Dillon, Rene Doyon, Jennifer Dunn, and Christian P. Riess Darren Erikson, Michael P. Fitzgerald, Donald Gavel, Stephen Goodsell, Markus Hartung, Pascale Hibon, 12764 A wave-mechanical model of incoherent quasielastic Paul Kalas, James Larkin, Jerome Maire, Franck scattering in complex systems Marchis, Mark S. Marley, James McBride, Max Hans Frauenfelder, Paul W. Fenimore, and Robert D. Young Millar-Blanchaer, Katie Morzinski, Andrew Norton, B. R. Oppenheimer, David Palmer, Jennifer Patience, Laurent Pueyo, Fredrik Rantakyro, Naru Sadakuni, Leslie Saddlemyer, Dmitry Savransky, Andrew Serio, SOCIAL SCIENCES Remi Soummer, Anand Sivaramakrishnan, Inseok Song, Sandrine Thomas, J. Kent Wallace, Sloane Wiktorowicz, ANTHROPOLOGY and Schuyler Wolff E3596 Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers CHEMISTRY George H. Perry, Matthieu Foll, Jean-Christophe Grenier, 12684 Label-free probe of HIV-1 TAT peptide binding to Etienne Patin, Yohann Nédélec, Alain Pacis, Maxime mimetic membranes Barakatt, Simon Gravel, Xiang Zhou, Sam L. Nsobya, Yi Rao, Sheldon J. J. Kwok, Julien Lombardi, Nicholas J. Laurent Excoffier, Lluis Quintana-Murci, Nathaniel J. Turro, and Kenneth B. Eisenthal Dominy, and Luis B. Barreiro 12758 Experimental basis for a new allosteric model for multisubunit proteins PSYCHOLOGICAL AND COGNITIVE SCIENCES Cristiano Viappiani, Stefania Abbruzzetti, Luca Ronda, E3726 The human dynamic clamp as a paradigm for Stefano Bettati, Eric. R. Henry, Andrea Mozzarelli, social interaction and William A. Eaton Guillaume Dumas, Gonzalo C. de Guzman, Emmanuelle Tognoli, and J. A. Scott Kelso

EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 12705 A critical reanalysis of the relationship between genomics and well-being 12655 Occurrence and core-envelope structure of 1–4× Nicholas J. L. Brown, Douglas A. MacDonald, Earth-size planets around Sun-like stars Manoj Pratim Samanta, Harris L. Friedman, Geoffrey W. Marcy, Lauren M. Weiss, Erik A. and James C. Coyne Petigura, Howard Isaacson, Andrew W. Howard, and Lars A. Buchhave 12710 Development of in-group favoritism in children’s third-party punishment of selfishness 12689 Trachyandesitic volcanism in the early Solar Jillian J. Jordan, Katherine McAuliffe, System and Felix Warneken Addi Bischoff, Marian Horstmann, Jean-Alix Barrat, Marc Chaussidon, Andreas Pack, Daniel Herwartz, Dustin Ward, Christian Vollmer, and Stephan Decker BIOLOGICAL SCIENCES

ENGINEERING AGRICULTURAL SCIENCES 12722 Refilling drug delivery depots through the blood 12716 Targeted gene knockout in chickens mediated Yevgeny Brudno, Eduardo A. Silva, Cathal J. Kearney, by TALENs Sarah A. Lewin, Alex Miller, Kathleen D. Martinick, Tae Sub Park, Hong Jo Lee, Ki Hyun Kim, Jin-Soo Kim, Michael Aizenberg, and David J. Mooney and Jae Yong Han

PNAS u September 2, 2014 u vol. 111 u no. 35 u v Downloaded by guest on September 24, 2021 ANTHROPOLOGY 12758 Experimental basis for a new allosteric model for E3596 Adaptive, convergent origins of the pygmy phenotype multisubunit proteins in African rainforest hunter-gatherers Cristiano Viappiani, Stefania Abbruzzetti, Luca Ronda, George H. Perry, Matthieu Foll, Jean-Christophe Grenier, Stefano Bettati, Eric. R. Henry, Andrea Mozzarelli, Etienne Patin, Yohann Nédélec, Alain Pacis, Maxime and William A. Eaton Barakatt, Simon Gravel, Xiang Zhou, Sam L. Nsobya, 12764 A wave-mechanical model of incoherent quasielastic Laurent Excoffier, Lluis Quintana-Murci, Nathaniel J. scattering in complex systems Dominy, and Luis B. Barreiro Hans Frauenfelder, Paul W. Fenimore, and Robert D. Young 12769 Protein crystal structure obtained at 2.9 Å resolution APPLIED BIOLOGICAL SCIENCES from injecting bacterial cells into an X-ray free-electron 12722 Refilling drug delivery depots through the blood laser beam Yevgeny Brudno, Eduardo A. Silva, Cathal J. Kearney, Michael R. Sawaya, Duilio Cascio, Mari Gingery, Jose Sarah A. Lewin, Alex Miller, Kathleen D. Martinick, Rodriguez, Lukasz Goldschmidt, Jacques-Philippe Colletier, Michael Aizenberg, and David J. Mooney Marc M. Messerschmidt, Sébastien Boutet, Jason E. Koglin, Garth J. Williams, Aaron S. Brewster, Karol Nass, Johan Hattne, Sabine Botha, R. Bruce Doak, Robert L. Shoeman, BIOCHEMISTRY Daniel P. DePonte, Hyun-Woo Park, Brian A. Federici, E3604 A unique PDZ domain and arrestin-like fold interaction Nicholas K. Sauter, Ilme Schlichting, and David S. Eisenberg reveals mechanistic details of endocytic recycling 12775 Formation and structures of GroEL:GroES chaperonin by SNX27-retromer 2 footballs, the protein-folding functional form Matthew Gallon, Thomas Clairfeuille, Florian Steinberg, Xue Fei, Xiang Ye, Nicole A. LaRonde, Caroline Mas, Rajesh Ghai, Richard B. Sessions, Rohan D. and George H. Lorimer Teasdale, Brett M. Collins, and Peter J. Cullen 12781 Crystal structure of a nematode-infecting virus E3614 Molecular architecture of mammalian nitric Yusong R. Guo, Corey F. Hryc, Joanita Jakana, oxide synthases Hongbing Jiang, David Wang, Wah Chiu, Weiwei Zhong, Melody G. Campbell, Brian C. Smith, Clinton S. Potter, and Yizhi J. Tao Bridget Carragher, and Michael A. Marletta 12787 Bioinformatic analysis reveals a pattern of 12728 Immunolocalization of skeletal matrix proteins in tissue STAT3-associated gene expression specific to and mineral of the coral Stylophora pistillata basal-like breast cancers in human tumors Tali Mass, Jeana L. Drake, Esther C. Peters, Wenge Jiang, Robert W. Tell and Curt M. Horvath and Paul G. Falkowski 12793 Assembly and dynamics of the autophagy-initiating 12734 Molecular mechanism of pH-dependent substrate Atg1 complex transport by an arginine-agmatine antiporter Goran Stjepanovic, Christopher W. Davies, Robin E. Stanley, Sheng Wang, Renhong Yan, Xi Zhang, Qi Chu, Michael J. Ragusa, Do Jin Kim, and James H. Hurley and Yigong Shi 12740 Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops CELL BIOLOGY Tatsuya Maehigashi, Jack A. Dunkle, Stacey J. Miles, E3631 Loss of Miro1-directed mitochondrial movement results and Christine M. Dunham in a novel murine model for neuron disease Tammy T. Nguyen, Sang S. Oh, David Weaver, Agnieszka 12746 Phospholipase A regulates eicosanoid class switching 2 Lewandowska, Dane Maxfield, Max-Hinderk Schuler, during inflammasome activation Nathan K. Smith, Jane Macfarlane, Gerald Saunders, Paul C. Norris, David Gosselin, Donna Reichart, Cheryl A. Palmer, Valentina Debattisti, Takumi Koshiba, Christopher K. Glass, and Edward A. Dennis Stefan Pulst, Eva L. Feldman, György Hajnóczky, 12752 Automodification switches PARP-1 function from and Janet M. Shaw chromatin architectural protein to histone chaperone E3641 IL-6/STAT3 promotes regeneration of airway ciliated Uma M. Muthurajan, Maggie R. D. Hepler, cells from basal stem cells Aaron R. Hieb, Nicholas J. Clark, Michael Kramer, Tomomi Tadokoro, Yang Wang, Larry S. Barak, Yushi Bai, Tingting Yao, and Karolin Luger Scott H. Randell, and Brigid L. M. Hogan 12591 Genetic and pharmacological reactivation of the BIOPHYSICS AND COMPUTATIONAL BIOLOGY mammalian inactive X chromosome E3624 Direct measurement of the dielectric polarization Sanchita Bhatnagar, Xiaochun Zhu, Jianhong Ou, properties of DNA Ling Lin, Lynn Chamberlain, Lihua J. Zhu, Ana Cuervo, Pablo D. Dans, José L. Carrascosa, Narendra Wajapeyee, and Michael R. Green Modesto Orozco, Gabriel Gomila, and Laura Fumagalli

12667 Gyrification from constrained cortical expansion ENVIRONMENTAL SCIENCES Tuomas Tallinen, Jun Young Chung, John S. Biggins, E3650 Stimulation of growth by proteorhodopsin phototrophy and L. Mahadevan involves regulation of central metabolic pathways in 12684 Label-free probe of HIV-1 TAT peptide binding to marine planktonic bacteria mimetic membranes Joakim Palovaara, Neelam Akram, Federico Baltar, Carina Yi Rao, Sheldon J. J. Kwok, Julien Lombardi, Nicholas J. Bunse, Jeremy Forsberg, Carlos Pedrós-Alió, José M. Turro, and Kenneth B. Eisenthal González, and Jarone Pinhassi

vi u www.pnas.org Downloaded by guest on September 24, 2021 12628 Requirements and limits for life in the context 12835 Activated group 3 innate lymphoid cells promote of exoplanets T-cell–mediated immune responses Christopher P. McKay Nicole von Burg, Stéphane Chappaz, Anne Baerenwaldt, Edit Horvath, Somdeb Bose Dasgupta, Devika Ashok, 12799 Fluvial network organization imprints on microbial Jean Pieters, Fabienne Tacchini-Cottier, Antonius Rolink, co-occurrence networks Hans Acha-Orbea, and Daniela Finke Stefanie Widder, Katharina Besemer, Gabriel A. Singer, Serena Ceola, Enrico Bertuzzo, Christopher Quince, 12841 CD1d-unrestricted NKT cells are endowed with a hybrid William T. Sloan, Andrea Rinaldo, and Tom J. Battin function far superior than that of iNKT cells Alexander R. Farr, Weisheng Wu, Bongkum Choi, EVOLUTION James D. Cavalcoli, and Yasmina Laouar E3659 A critical appraisal of the use of microRNA data in phylogenetics MEDICAL SCIENCES Robert C. Thomson, David C. Plachetzki, D. Luke Mahler, E3689 The role of PI3K/AKT-related PIP5K1α and the discovery and Brian R. Moore of its selective inhibitor for treatment of advanced See Commentary on page 12576 prostate cancer Julius Semenas, Andreas Hedblom, Regina R. Miftakhova, 12805 Introgression in hybrid ants is favored in females but Martuza Sarwar, Rikard Larsson, Liliya Shcherbina, selected against in males Martin E. Johansson, Pirkko Härkönen, Olov Sterner, Jonna Kulmuni and Pekka Pamilo and Jenny L. Persson See Commentary on page 12578 GENETICS 12847 Adaptive growth factor delivery from a polyelectrolyte 12705 A critical reanalysis of the relationship between coating promotes synergistic bone tissue repair genomics and well-being and reconstruction Nicholas J. L. Brown, Douglas A. MacDonald, Nisarg J. Shah, Md. Nasim Hyder, Mohiuddin A. Quadir, Manoj Pratim Samanta, Harris L. Friedman, Noémie-Manuelle Dorval Courchesne, Howard J. Seeherman, and James C. Coyne Myron Nevins, Myron Spector, and Paula T. Hammond 12811 UV damage-induced RNA polymerase II stalling 12853 (R)-PFI-2 is a potent and selective inhibitor of SETD7 stimulates H2B deubiquitylation methyltransferase activity in cells Peng Mao, Rithy Meas, Kathleen M. Dorgan, Dalia Barsyte-Lovejoy, Fengling Li, Menno J. Oudhoff, and Michael J. Smerdon John H. Tatlock, Aiping Dong, Hong Zeng, Hong Wu, 12817 Mutation of Plekha7 attenuates salt-sensitive Spencer A. Freeman, Matthieu Schapira, Guillermo A. hypertension in the rat Senisterra, Ekaterina Kuznetsova, Richard Marcellus, Bradley T. Endres, Jessica R. C. Priestley, Oleg Palygin, Abdellah Allali-Hassani, Steven Kennedy, Jean-Philippe Michael J. Flister, Matthew J. Hoffman, Brian D. Weinberg, Lambert, Amber L. Couzens, Ahmed Aman, Anne-Claude Michael Grzybowski, Julian H. Lombard, Alexander Gingras, Rima Al-Awar, Paul V. Fish, Brian S. Gerstenberger, Staruschenko, Carol Moreno, Howard J. Jacob, Lee Roberts, Caroline L. Benn, Rachel L. Grimley, and Aron M. Geurts Mitchell J. S. Braam, Fabio M. V. Rossi, Marius Sudol, Peter J. Brown, Mark E. Bunnage, Dafydd R. Owen, IMMUNOLOGY AND INFLAMMATION Colby Zaph, Masoud Vedadi, and Cheryl H. Arrowsmith −/− E3669 Mannan induces ROS-regulated, IL-17A–dependent 12859 Nedd9 restrains renal cystogenesis in Pkd1 mice psoriasis arthritis-like disease in mice Anna S. Nikonova, Olga V. Plotnikova, Victoria Serzhanova, Ia Khmaladze, Tiina Kelkka, Simon Guerard, Kajsa Wing, Andrey Efimov, Igor Bogush, Kathy Q. Cai, Harvey H. Angela Pizzolla, Amit Saxena, Katarina Lundqvist, Meirav Hensley, Brian L. Egleston, Andres Klein-Szanto, Holmdahl, Kutty Selva Nandakumar, and Rikard Holmdahl Tamina Seeger-Nukpezah, and Erica A. Golemis E3679 A sharp T-cell antigen receptor signaling threshold for 12865 Endothelial Akt1 mediates angiogenesis by T-cell proliferation phosphorylating multiple angiogenic substrates Byron B. Au-Yeung, Julie Zikherman, James L. Mueller, Monica Y. Lee, Amelia K. Luciano, Eric Ackah, Juan Judith F. Ashouri, Mehrdad Matloubian, Debra A. Cheng, Rodriguez-Vita, Tara A. Bancroft, Anne Eichmann, Yiling Chen, Kevan M. Shokat, and Arthur Weiss Michael Simons, Themis R. Kyriakides, Manuel Morales-Ruiz, and William C. Sessa 12823 Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid 12871 Primary cilia signaling mediates intraocular pressure cells in glioblastoma patients sensation Courtney A. Crane, Kathryn Austgen, Kristen Haberthur, Na Luo, Michael D. Conwell, Xingjuan Chen, Carly Hofmann, Kara White Moyes, Lia Avanesyan, Lawrence Christine Insinna Kettenhofen, Christopher J. Westlake, Fong, Michael J. Campbell, Stewart Cooper, Scott A. Oakes, Louis B. Cantor, Clark D. Wells, Robert N. Weinreb, Andrew T. Parsa, and Lewis L. Lanier Timothy W. Corson, Dan F. Spandau, Karen M. Joos, Carlo Iomini, Alexander G. Obukhov, and Yang Sun 12829 Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells Yukiko Watanabe, Atsushi Onodera, Urara Kanai, Tomomi MICROBIOLOGY Ichikawa, Kazushige Obata-Ninomiya, Tomoko Wada, E3699 TIM-family proteins inhibit HIV-1 release Masahiro Kiuchi, Chiaki Iwamura, Damon J. Tumes, Minghua Li, Sherimay D. Ablan, Chunhui Miao, Yi-Min Kenta Shinoda, Ryoji Yagi, Shinichiro Motohashi, Zheng, Matthew S. Fuller, Paul D. Rennert, Wendy Maury, Kiyoshi Hirahara, and Toshinori Nakayama Marc C. Johnson, Eric O. Freed, and Shan-Lu Liu

PNAS u September 2, 2014 u vol. 111 u no. 35 u vii Downloaded by guest on September 24, 2021 E3708 Xylan utilization in human gut commensal bacteria 12907 Tip-link protein protocadherin 15 interacts with is orchestrated by unique modular organization transmembrane channel-like proteins TMC1 and TMC2 of polysaccharide-degrading enzymes Reo Maeda, Katie S. Kindt, Weike Mo, Clive P. Morgan, Meiling Zhang, Jonathan R. Chekan, Dylan Dodd, Timothy Erickson, Hongyu Zhao, Rachel Clemens-Grisham, Pei-Ying Hong, Lauren Radlinski, Vanessa Revindran, Peter G. Barr-Gillespie, and Teresa Nicolson Satish K. Nair, Roderick I. Mackie, and Isaac Cann 12913 Optogenetic neuronal stimulation promotes functional E3718 Reconstruction and minimal gene requirements recovery after stroke for the alternative iron-only nitrogenase in Michelle Y. Cheng, Eric H. Wang, Wyatt J. Woodson, Escherichia coli Stephanie Wang, Guohua Sun, Alex G. Lee, Ahmet Arac, Jianguo Yang, Xiaqing Xie, Xia Wang, Ray Dixon, Lief E. Fenno, Karl Deisseroth, and Gary K. Steinberg and Yi-Ping Wang 12919 Interlamellar CA1 network in the hippocampus 12877 Bacillus subtilis chromosome organization oscillates Sunggu Yang, Sungchil Yang, Thais Moreira, Gloria between two distinct patterns Hoffman, Greg C. Carlson, Kevin J. Bender, Xindan Wang, Paula Montero Llopis, and David Z. Rudner Bradley E. Alger, and Cha-Min Tang See Commentary on page 12580 12883 Shewanella oneidensis MR-1 nanowires are outer PHARMACOLOGY membrane and periplasmic extensions of the E3745 Hampered long-term depression and thin spine loss extracellular electron transport components in the nucleus accumbens of ethanol-dependent rats Sahand Pirbadian, Sarah E. Barchinger, Kar Man Leung, Saturnino Spiga, Giuseppe Talani, Giovanna Mulas, Hye Suk Byun, Yamini Jangir, Rachida A. Bouhenni, Valentina Licheri, Giulia R. Fois, Giulia Muggironi, Samantha B. Reed, Margaret F. Romine, Daad A. Nicola Masala, Carla Cannizzaro, Giovanni Biggio, Saffarini, Liang Shi, Yuri A. Gorby, John H. Golbeck, Enrico Sanna, and Marco Diana and Mohamed Y. El-Naggar 12925 Roles of cGMP-dependent protein kinase I (cGKI) 12889 Robustness against serum neutralization of a and PDE5 in the regulation of Ang II-induced poliovirus type 1 from a lethal epidemic of cardiac hypertrophy and fibrosis poliomyelitis in the Republic of Congo in 2010 Enrico Patrucco, Katrin Domes, Mauro Sbroggió, Jan Felix Drexler, Gilda Grard, Alexander N. Anne Blaich, Jens Schlossmann, Matthias Desch, Lukashev, Liubov I. Kozlovskaya, Sindy Böttcher, Sergei D. Rybalkin, Joseph A. Beavo, Robert Lukowski, Gökhan Uslu, Johan Reimerink, Anatoly P. Gmyl, and Franz Hofmann Raphaël Taty-Taty, Sonia Etenna Lekana-Douki, Dieudonné Nkoghe, Anna M. Eis-Hübinger, Sabine PHYSIOLOGY Diedrich, Marion Koopmans, Eric M. Leroy, and Christian Drosten 12930 Pseudomonas aeruginosa triggers CFTR-mediated airway surface liquid secretion in swine trachea 12895 A lipid zipper triggers bacterial invasion Xiaojie Luan, Verónica A. Campanucci, Manoj Nair, Thorsten Eierhoff, Björn Bastian, Roland Thuenauer, Orhan Yilmaz, George Belev, Terry E. Machen, Josef Madl, Aymeric Audfray, Sahaja Aigal, Samuel Dean Chapman, and Juan P. Ianowski Juillot, Gustaf E. Rydell, Stefan Müller, Sophie de Bentzmann, Anne Imberty, Christian Fleck, PLANT BIOLOGY and Winfried Römer 12936 Rare earth elements activate endocytosis in plant cells 12901 Efficient utilization of complex N-linked glycans is Lihong Wang, Jigang Li, Qing Zhou, Guangmei Yang, a selective advantage for Bacteroides fragilis in Xiao Lan Ding, Xiaodong Li, Chen Xin Cai, Zhao Zhang, extraintestinal infections Hai Yan Wei, Tian Hong Lu, Xing Wang Deng, Yanlu Cao, Edson R. Rocha, and C. Jeffrey Smith and Xiao Hua Huang 12942 Tomato yellow leaf curl virus resistance by Ty-1 involves NEUROSCIENCE increased cytosine methylation of viral genomes and E3726 The human dynamic clamp as a paradigm for is compromised by cucumber mosaic virus infection social interaction Patrick Butterbach, Maarten G. Verlaan, Annette Guillaume Dumas, Gonzalo C. de Guzman, Dullemans, Dick Lohuis, Richard G. F. Visser, Emmanuelle Tognoli, and J. A. Scott Kelso Yuling Bai, and Richard Kormelink E3735 Narcolepsy patients have antibodies that stain SUSTAINABILITY SCIENCE distinct cell populations in rat brain and influence sleep patterns 12948 Effect of woody-plant encroachment on livestock Peter Bergman, Csaba Adori, Szilvia Vas, Ylva production in North and South America Kai-Larsen, Tomi Sarkanen, Andreas Cederlund, José D. Anadón, Osvaldo E. Sala, B. L. Turner II, Birgitta Agerberth, Ilkka Julkunen, Beata Horvath, and Elena M. Bennett Diana Kostyalik, Lajos Kalmár, Gyorgy Bagdy, Anne Huutoniemi, Markku Partinen, and Tomas Hökfelt ix Subscription Form

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