Punicalagin Content and Antifungal Activity of Different
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Chemical Composition, Antioxidant Activity, and Sensory Characterization of Commercial Pomegranate Juices
antioxidants Article Chemical Composition, Antioxidant Activity, and Sensory Characterization of Commercial Pomegranate Juices Sonia Esposto, Gianluca Veneziani, Agnese Taticchi, Stefania Urbani, Roberto Selvaggini, Beatrice Sordini * , Luigi Daidone, Giacomo Gironi and Maurizio Servili Department of Agricultural, Food and Environmental Sciences, University of Perugia, Via San Costanzo s.n.c., 06126 Perugia, Italy; [email protected] (S.E.); [email protected] (G.V.); [email protected] (A.T.); [email protected] (S.U.); [email protected] (R.S.); [email protected] (L.D.); [email protected] (G.G.); [email protected] (M.S.) * Correspondence: [email protected]; Tel.: +39-075-5857951; Fax: +39-075-5857916 Abstract: We undertook a qualitative and quantitative assessment of the bioactive compounds, volatile substances, sensory profile, and antioxidant activity of eight different commercial pomegranate juices (PJs) differing by cultivation area, processing (from concentrate (CPJ) or not (NCPJ)), and mi- crobial stabilization. Punicalins were the main ellagitannins, whereas the predominant anthocyanin was cyanidin 3,5-diglucoside, followed by cyanidin 3-glucoside. Total phenols, tannins, hydrolyzable tannins, and anthocyanins in the investigated juices ranged from 1379.9 to 3748.8 mg gallic acid equivalent (GAE)/L, 394.8 to 895.2 mg GAE/L, 150.8 to 2374.2 mg ellagic acid/L, and 0 to 281 mg • cyanidin 3-glucoside/L, respectively. Antioxidant activity, determined by DPPH , FRAP, and ABTS, was positively correlated with the total phenolic compounds and hydrolyzable tannins. Alcohols, Citation: Esposto, S.; Veneziani, G.; acids, and furans were the volatile groups that best described the differences between juices. -
Punicalin Alleviates OGD/R-Triggered Cell Injury Via TGF-Β-Mediated Oxidative Stress and Cell Cycle in Neuroblastoma Cells SH-SY5Y
Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2021, Article ID 6671282, 11 pages https://doi.org/10.1155/2021/6671282 Research Article Punicalin Alleviates OGD/R-Triggered Cell Injury via TGF-β-Mediated Oxidative Stress and Cell Cycle in Neuroblastoma Cells SH-SY5Y Tiansong Yang,1 Qingyong Wang,2 Yuanyuan Qu,2 Yan Liu,1 Chuwen Feng,1 Yulin Wang,2 Weibo Sun,3 Zhongren Sun ,2 and Yulan Zhu4 1First affiliated hospital, Heilongjiang University of Chinese Medicine, Harbin, China 2Heilongjiang University of Chinese Medicine, Harbin, China 3Harbin Medical University, Harbin, China 4Department of Neurology, %e Second Affiliated Hospital of Harbin Medical University, Harbin, China Correspondence should be addressed to Zhongren Sun; [email protected] Received 21 October 2020; Revised 21 October 2020; Accepted 7 January 2021; Published 12 February 2021 Academic Editor: Muhammad Farrukh Nisar Copyright © 2021 Tiansong Yang et al. /is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. /e research aimed to identify the active component from Punica granatum L. to alleviate ischemia/reperfusion injury and clarify the underlying mechanism of the active component alleviating ischemia/reperfusion injury. Materials and Methods. /e SH-SY5Y cell model of oxygen-glucose deprivation/reoxygenation (OGD/R) was established to simulate the ischemia/ reperfusion injury. According to the strategy of bioassay-guided isolation, the active component of punicalin from Punica granatum L. was identified. Flow cytometry and Western blotting were employed to evaluate the effects of OGD/R and/or punicalin on cell cycle arrest. -
A Review on Antihyperglycemic and Antihepatoprotective Activity of Eco-Friendly Punica Granatum Peel Waste
Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 656172, 10 pages http://dx.doi.org/10.1155/2013/656172 Review Article A Review on Antihyperglycemic and Antihepatoprotective Activity of Eco-Friendly Punica granatum Peel Waste Sushil Kumar Middha,1 Talambedu Usha,2 and Veena Pande1 1 Department of Biotechnology, Bhimtal Campus, Kumaun University, Nainital, Uttarakhand 263136, India 2 Department of Biotechnology & Biochemistry, Maharani Lakshmi Ammanni College for Women, Bangalore 560012, India Correspondence should be addressed to Veena Pande; veena [email protected] Received 28 December 2012; Revised 25 March 2013; Accepted 25 April 2013 Academic Editor: Edwin L. Cooper Copyright © 2013 Sushil Kumar Middha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Over the past decade, pomegranate (Punica granatum) is entitled as a wonder fruit because of its voluminous pharmacological properties. In 1830, P. g ranatum fruit was first recognized in United States Pharmacopeia; the Philadelphia edition introduced the rind of the fruit, the New York edition the bark of the root and further 1890 edition the stem bark was introduced. There are significant efforts and progress made in establishing thepharmacological mechanisms of peel (pericarp or rind) and the individual constituents responsible for them. This review provides an insight on the phytochemical components that contribute too antihyperglycemic, hepatoprotective, antihyperlipidemic effect, and numerous other effects of wonderful, economic, and eco- friendly pomegranate peel extract (PP). 1. Introduction containing sacs packed with a fleshy, juicy, red or whitish pulp. -
Evaluation of Punicalagin Niosomes for Skin Aging
Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 24 March 2021 Evaluation of Punicalagin Niosomes for Skin Aging Ebtesam A. Mohamada, Aya A. Alyb, Aya A. Khalafb, Mona I. Ahmedb, Reham M. Kamelb, Sherouk M. Abdelnabyb, Yasmine H. Abdelzaherb, Marize G. Sedrak b, Shaker A. Mousac a Biophysics Department, Faculty of Science, Cairo University, Cairo, Egypt; b Biotechnology / Biomolecular Chemistry Program, Faculty of Science, Cairo University, Cairo, Egypt; c The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA *Corresponding Author: Shaker A. Mousa, PhD, MBA, FACC, FACB Professor of Pharmacology and Chairman of The Pharmaceutical Research Institute Albany College of Pharmacy and Health Sciences Rensselaer, NY 12144, USA Email: [email protected] Tel: +1-518-694-7397 & Fax: +1-518-694-7567 Abstract Skin aging is one of the most common problems facing humanity. It occurs because of altering the balance between free radicals and antioxidants and increasing the amount of the reactive oxygen species (ROS) in skin cells, which leads to oxidative stress especially when exposed to UV radiation. Antioxidants can neutralize the harmful effects of ROS, and secondary plant metabolites can help protect against UV radiation. In this study, punicalagin was extracted from pomegranate and concentrations of total polyphenolics and flavonoids were determined and antioxidant activities measured. Punicalagin was loaded onto niosomes and its morphology and release were studied. An in vitro study was performed on human fibroblast cell line HFB4 cells with aging induced by H2O2 and UV radiation. Cell cycle arrest was studied and different genes (MMP3, Col1A1, Timp3, and TERT) involved in the skin aging process were selected to measure punicalagin's effect. -
Pomegranate: Nutraceutical with Promising Benefits on Human Health
Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 8 September 2020 Review Pomegranate: nutraceutical with promising benefits on human health Anna Caruso 1, +, Alexia Barbarossa 2,+, Antonio Tassone 1 , Jessica Ceramella 1, Alessia Carocci 2,*, Alessia Catalano 2,* Giovanna Basile 1, Alessia Fazio 1, Domenico Iacopetta 1, Carlo Franchini 2 and Maria Stefania Sinicropi 1 1 Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Arcavacata di Rende (Italy); anna.caruso@unical .it (Ann.C.), [email protected] (A.T.), [email protected] (J.C.), [email protected] (G.B.), [email protected] (A.F.), [email protected] (D.I.), [email protected] (M.S.S.) 2 Department of Pharmacy‐Drug Sciences, University of Bari “Aldo Moro”, 70126, Bari (Italy); [email protected] (A.B.), [email protected] (Al.C.), [email protected] (A.C.), [email protected] (C.F.) + These authors equally contributed to this work. * Correspondence: [email protected] Abstract: The pomegranate, an ancient plant native to Central Asia, cultivated in different geographical areas including the Mediterranean basin and California, consists of flowers, roots, fruits and leaves. Presently, it is utilized not only for the exterior appearance of its fruit but above all, for the nutritional and health characteristics of the various parts composing this last one (carpellary membranes, arils, seeds and bark). The fruit, the pomegranate, is rich in numerous chemical compounds (flavonoids, ellagitannins, proanthocyanidins, mineral salts, vitamins, lipids, organic acids) of high biological and nutraceutical value that make it the object of study for many research groups, particularly in the pharmaceutical sector. -
278-281 Research Article Computational Studies on The
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2014, 6(9):278-281 ISSN : 0975-7384 Research Article CODEN(USA) : JCPRC5 Computational studies on the antiobesity effect of polyphenols from pomegranate leaf Sudeep H. V.* and Shyam Prasad K. Department of Biomedicinal Research, Vidya Herbs Pvt. Ltd, #101, Jigani II phase, Bangalore, Karnataka, India _____________________________________________________________________________________________ ABSTRACT Different polyphenols present in Pomegranate leaves were docked into validated drug targets of obesity which include enzymes pancreatic lipase and fat mass and obesity associated protein (FTO). The in silico calculations predicted that lowest energy docked poses of phenolic compounds can interact with catalysis-dependent residues, thus making them possible catalytic inhibitors and of course physiologically active. Compounds that possess a number of hydrogen-bond-accepting and/or -donating groups like phenolics and quinones show extensive interactions with the targets. Based on the ligand-protein interaction we can conclude that phenolic principles like Punicalagin, corilagin, punicalin and apigenin thus offer profound promise as anti-obesity drugs. This study has immediate applications in development of non-toxic drugs/nutraceuticals that may safeguard human populations against severe complications associated with obesity. Key words: Docking, Obesity, Pomegranate, Polyphenols _____________________________________________________________________________________________ INTRODUCTION Weight gain and obesity are major risk factors for the health complications ranging from insulin resistance and type 2 diabetes mellitus to atherosclerosis and the sequelae of nonalcoholic fatty liver disease[1]. Physiologically, obesity is a disarray of energy balance and primarily considered as a disorder of lipid metabolism[2]. The condition is associated with a growing number of enzymes involved in lipid metabolic pathways. -
Unravelling the Antibacterial Activity of Terminalia Sericea Root Bark Through a Metabolomic Approach
molecules Article Unravelling the Antibacterial Activity of Terminalia sericea Root Bark through a Metabolomic Approach Chinedu P Anokwuru 1,2, Sidonie Tankeu 2, Sandy van Vuuren 3 , Alvaro Viljoen 2,4, Isaiah D. I Ramaite 1 , Orazio Taglialatela-Scafati 5 and Sandra Combrinck 2,* 1 Department of Chemistry, University of Venda, Private Bag X5050, Thohoyandou 0950, South Africa; [email protected] (C.P.A.); [email protected] (I.D.I.R.) 2 Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South Africa; [email protected] (S.T.); [email protected] (A.V.) 3 Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa; [email protected] 4 SAMRC Herbal Drugs Research Unit, Faculty of Science, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South Africa 5 Department of Pharmacy, University of Naples, Federico II Via D. Montesano 49, 1-80131 Napoli, Italy; [email protected] * Correspondence: [email protected]; Tel./Fax: +27-84-402-7463 Academic Editor: Souvik Kusari Received: 20 July 2020; Accepted: 7 August 2020; Published: 13 August 2020 Abstract: Terminalia sericea Burch. ex. DC. (Combretaceae) is a popular remedy for the treatment of infectious diseases. It is widely prescribed by traditional healers and sold at informal markets and may be a good candidate for commercialisation. For this to be realised, a thorough phytochemical and bioactivity profile is required to identify constituents that may be associated with the antibacterial activity and hence the quality of raw materials and consumer products. -
Chapter 6 ENUMERATION
Chapter 6 ENUMERATION . ENUMERATION The spermatophytic plants with their accepted names as per The Plant List [http://www.theplantlist.org/ ], through proper taxonomic treatments of recorded species and infra-specific taxa, collected from Gorumara National Park has been arranged in compliance with the presently accepted APG-III (Chase & Reveal, 2009) system of classification. Further, for better convenience the presentation of each species in the enumeration the genera and species under the families are arranged in alphabetical order. In case of Gymnosperms, four families with their genera and species also arranged in alphabetical order. The following sequence of enumeration is taken into consideration while enumerating each identified plants. (a) Accepted name, (b) Basionym if any, (c) Synonyms if any, (d) Homonym if any, (e) Vernacular name if any, (f) Description, (g) Flowering and fruiting periods, (h) Specimen cited, (i) Local distribution, and (j) General distribution. Each individual taxon is being treated here with the protologue at first along with the author citation and then referring the available important references for overall and/or adjacent floras and taxonomic treatments. Mentioned below is the list of important books, selected scientific journals, papers, newsletters and periodicals those have been referred during the citation of references. Chronicles of literature of reference: Names of the important books referred: Beng. Pl. : Bengal Plants En. Fl .Pl. Nepal : An Enumeration of the Flowering Plants of Nepal Fasc.Fl.India : Fascicles of Flora of India Fl.Brit.India : The Flora of British India Fl.Bhutan : Flora of Bhutan Fl.E.Him. : Flora of Eastern Himalaya Fl.India : Flora of India Fl Indi. -
Production and Extraction by Solid-State Fermentation. a Review
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Universidade do Minho: RepositoriUM Biotechnology Advances 29 (2011) 365–373 Contents lists available at ScienceDirect Biotechnology Advances journal homepage: www.elsevier.com/locate/biotechadv Research review paper Bioactive phenolic compounds: Production and extraction by solid-state fermentation. A review Silvia Martins a, Solange I. Mussatto a,⁎, Guillermo Martínez-Avila b, Julio Montañez-Saenz c, Cristóbal N. Aguilar b, Jose A. Teixeira a a Institute for Biotechnology and Bioengineering (IBB), Centre of Biological Engineering, University of Minho, Campus Gualtar, 4710–057, Braga, Portugal b Food Research Department, School of Chemistry, Autonomous University of Coahuila, Blvd. Venustiano Carranza S/N Col. República Oriente, 25280, Saltillo, Coahuila, Mexico c Department of Chemical Engineering, School of Chemistry, Autonomous University of Coahuila, Blvd. Venustiano Carranza S/N Col. República Oriente, 25280, Saltillo, Coahuila, Mexico article info abstract Article history: Interest in the development of bioprocesses for the production or extraction of bioactive compounds from Received 27 July 2010 natural sources has increased in recent years due to the potential applications of these compounds in food, Received in revised form 20 January 2011 chemical, and pharmaceutical industries. In this context, solid-state fermentation (SSF) has received great Accepted 21 January 2011 attention because this bioprocess has potential to successfully convert inexpensive agro-industrial residues, Available online 1 February 2011 as well as plants, in a great variety of valuable compounds, including bioactive phenolic compounds. The aim Keywords: of this review, after presenting general aspects about bioactive compounds and SSF systems, is to focus on the Solid-state fermentation production and extraction of bioactive phenolic compounds from natural sources by SSF. -
Le Bioraffinage De Myrrhis Odorata, Tussilago Farfara Et Calamintha Grandiflora Pour La Production D'aromes Et D'antioxydants
En vue de l'obtention du DOCTORAT DE L'UNIVERSITÉ DE TOULOUSE Délivré par : Institut National Polytechnique de Toulouse (INP Toulouse) Discipline ou spécialité : Sciences des Agroressources Présentée et soutenue par : Mme DIANA DOBRAVALSKYTE le lundi 25 novembre 2013 Titre : LE BIORAFFINAGE DE MYRRHIS ODORATA, TUSSILAGO FARFARA ET CALAMINTHA GRANDIFLORA POUR LA PRODUCTION D'AROMES ET D'ANTIOXYDANTS. Ecole doctorale : Sciences de la Matière (SM) Unité de recherche : Laboratoire de Chimie Agro-Industrielle (L.C.A.) Directeur(s) de Thèse : M. THIERRY TALOU M. RIMANTAS VENSKUTONIS Rapporteurs : Mme CHANTAL MENUT, UNIVERSITE MONTPELLIER 2 Mme JOLANTA LIESIENE, UNIVERSITE DE TECHNOLOGIE DE KAUNAS Membre(s) du jury : 1 M. ZIGMUNTAS BERESNEVICIUS, UNIVERSITE DE TECHNOLOGIE DE KAUNAS, Président 2 M. ALGIRDAS ZEMAITAITIS, UNIVERSITE DE TECHNOLOGIE DE KAUNAS, Membre 2 Mme GRAZINA JUODEIKIENÉ, UNIVERSITE DE TECHNOLOGIE DE KAUNAS, Membre 2 Mme ISABELLE FOURASTE, UNIVERSITE TOULOUSE 3, Membre 2 Mme RUTA GALABURDA, LATVIA UNIVERSITY OF AGRICULTURE JELGAVA, Membre 2 M. RIMANTAS VENSKUTONIS, UNIVERSITE DE TECHNOLOGIE DE KAUNAS, Membre REMERCIEMENTS Tout d’abord j’adresse mes remerciements aux différents organismes qui ont mis les moyens financiers pour l’aboutissement de cette thèse: aux gouvernements de la Lituanie et la France, ainsi que Campus France avec la bourse d'Excellence Égide Eiffel. Je remercie les Professeurs Dr. Jolanta LIESIENĖ et Dr. Chantal MENUT pour m'avoir fait l'honneur d'être les rapporteurs de ma thèse. Je remercie également les professeurs Dr. Algirdas ŽEMAITAITIS, Dr. Gražina JUODEIKIENĖ, Dr. Zigmuntas Jonas BERESNEVIČIUS, Dr. Isabelle FOURASTÉ, Dr. Audrius Sigitas MARUŠKA et Dr. Ruta GALOBURDA d’avoir participés en tant qu’examinateurs. -
Combretaceae: Phylogeny, Biogeography and DNA
COPYRIGHT AND CITATION CONSIDERATIONS FOR THIS THESIS/ DISSERTATION o Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. o NonCommercial — You may not use the material for commercial purposes. o ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original. How to cite this thesis Surname, Initial(s). (2012) Title of the thesis or dissertation. PhD. (Chemistry)/ M.Sc. (Physics)/ M.A. (Philosophy)/M.Com. (Finance) etc. [Unpublished]: University of Johannesburg. Retrieved from: https://ujdigispace.uj.ac.za (Accessed: Date). Combretaceae: Phylogeny, Biogeography and DNA Barcoding by JEPHRIS GERE THESIS Submitted in fulfilment of the requirements for the degree PHILOSOPHIAE DOCTOR in BOTANY in the Faculty of Science at the University of Johannesburg December 2013 Supervisor: Prof Michelle van der Bank Co-supervisor: Dr Olivier Maurin Declaration I declare that this thesis has been composed by me and the work contained within, unless otherwise stated, is my own. _____________________ J. Gere (December 2013) Table of contents Table of contents i Abstract v Foreword vii Index to figures ix Index to tables xv Acknowledgements xviii List of abbreviations xxi Chapter 1: General introduction and objectives 1.1 General introduction 1 1.2 Vegetative morphology 2 1.2.1 Leaf morphology and anatomy 2 1.2.2. Inflorescence 3 1.2.3 Fruit morphology 4 1.3 DNA barcoding 5 1.4 Cytology 6 1.5 Fossil record 7 1.6 Distribution and habitat 7 1.7 Economic Importance 8 1.8 Taxonomic history 9 1.9 Aims and objectives of the study 11 i Table of contents Chapter 2: Molecular phylogeny of Combretaceae with implications for infrageneric classification within subtribe Terminaliinae. -
Oksana Et Al
Journal of Medicinal Plants Research Vol. 6(13), pp. 2526-2539, 9 April, 2012 Available online at http://www.academicjournals.org/JMPR DOI: 10.5897/JMPR11.1695 ISSN 1996-0875 ©2012 Academic Journals Review Plant phenolic compounds for food, pharmaceutical and cosmeti сs production Sytar Oksana 1,2 , Brestic Marian 1,4 , Rai Mahendra 3 and Shao Hong Bo 1,4,5 * 1Department of Plant Physiology, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia. 2Department of Plant Physiology and Ecology, Taras Shevchenko National University of Kyiv, Volodymyrs'ka St. 64, 01601 Kyiv, Ukraine. 3Department of Biotechnology, SGB Amravati University, Maharashrta, India. 4Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Chunhui Rd.17, Yantai 264003, China. 5Institute of Life Sciences Qingdao University of Science and Technology, Zhengzhou Road 53, Qingdao 266042, China. Accepted 17 February, 2012 The biochemical features and biological function of dietary phenols, which are widespread in the plant kingdom, have been described in the present review. The ways of phenols classification, which were collected from literature based on structural and biochemical characteristics with description of source and possible effects on human, organisms and environment have been presented. The bioactivities of phenolic compounds described in literature are reviewed to illustrate their potential for the development of pharmaceutical and agricultural products. Key words: Plant phenols, phenolic acids, flavonoids, cathecins, tannins, food industry. INTRODUCTION Phenolic compounds are plant secondary metabolites skeleton: C6 (simple phenol, benzoquinones), C6-C1 that constitute one of the most common and widespread (phenolic acid), C6-C2 (acetophenone, phenylacetic groups of substances in plants (Whiting, 2001).