WSC 14-15 Conf 1 Layout
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Evaluation of Genotoxicity and Cytotoxicity Amongst in Dental
Dental, Oral and Craniofacial Research Research Article ISSN: 2058-5314 Evaluation of genotoxicity and cytotoxicity amongst in dental surgeons and technicians by micronucleus assay Molina Noyola Leonardo Daniel1,2, Coronado Romo María Eugenia3, Vázquez Alcaraz Silverio Jafet4, Izaguirre Pérez Marian Eliza1,2, Arellano-García Evarista5, Flores-García Aurelio6 and Torres Bugarín Olivia1* 1Laboratorio de Evaluación de Genotóxicos, Programa Internacional de Medicina, Universidad Autónoma de Guadalajara, Mexico 2Facultad de Medicina, Universidad Autónoma de Guadalajara, Mexico 3Departamento de Ortodoncia, Facultad de Odontología, Universidad Autónoma de Guadalajara, Mexico 4Departamento de Endodoncia, Facultad de Odontología, Universidad Autónoma de Guadalajara, Mexico 5Facultad de Ciencias, Universidad Autónoma de Baja California, Mexico 6Unidad Académica de Medicina, Universidad Autónoma de Nayarit, Tepic, Nayarit, Mexico Abstract Introduction: Dental surgeons and technicians are continuously exposed to agents could be affect the genetic material and induce mutations. The aim of this study was to evaluate the genotoxic and cytotoxic occupational risk of dental surgeons and technicians through the micronucleated cells (MNC) and nuclear abnormalities (NA) assay in oral mucosa. Methods: Case-control study. We have collected a buccal mucosa from dental surgeons, dental technicians and healthy individuals (matched by BMI, age and gender). The smears were fixed (ethanol 80%/48 h), stained (orange acridine) and analyzed (microscope, 100×). The frequency of MNC and NA (binucleated cells [BNC], lobulated nucleus [LN], condensed chromatins [CC], karyorrhexis [KR], pyknosis (PN) and karyolysis [KL] were counted in 2,000 cells per participant. Results: 90 samples were collected (26 surgeons, 19 technicians and 45 controls). Compared with controls, exception of PN, in surgeons was higher frequency and positive association of MNC and all NA (p<0.05). -
General Pathomorpholog.Pdf
Ukrаiniаn Medicаl Stomаtologicаl Аcаdemy THE DEPАRTАMENT OF PАTHOLOGICАL АNАTOMY WITH SECTIONSL COURSE MАNUАL for the foreign students GENERАL PАTHOMORPHOLOGY Poltаvа-2020 УДК:616-091(075.8) ББК:52.5я73 COMPILERS: PROFESSOR I. STАRCHENKO ASSOCIATIVE PROFESSOR O. PRYLUTSKYI АSSISTАNT A. ZADVORNOVA ASSISTANT D. NIKOLENKO Рекомендовано Вченою радою Української медичної стоматологічної академії як навчальний посібник для іноземних студентів – здобувачів вищої освіти ступеня магістра, які навчаються за спеціальністю 221 «Стоматологія» у закладах вищої освіти МОЗ України (протокол №8 від 11.03.2020р) Reviewers Romanuk A. - MD, Professor, Head of the Department of Pathological Anatomy, Sumy State University. Sitnikova V. - MD, Professor of Department of Normal and Pathological Clinical Anatomy Odessa National Medical University. Yeroshenko G. - MD, Professor, Department of Histology, Cytology and Embryology Ukrainian Medical Dental Academy. A teaching manual in English, developed at the Department of Pathological Anatomy with a section course UMSA by Professor Starchenko II, Associative Professor Prylutsky OK, Assistant Zadvornova AP, Assistant Nikolenko DE. The manual presents the content and basic questions of the topic, practical skills in sufficient volume for each class to be mastered by students, algorithms for describing macro- and micropreparations, situational tasks. The formulation of tests, their number and variable level of difficulty, sufficient volume for each topic allows to recommend them as preparation for students to take the licensed integrated exam "STEP-1". 2 Contents p. 1 Introduction to pathomorphology. Subject matter and tasks of 5 pathomorphology. Main stages of development of pathomorphology. Methods of pathanatomical diagnostics. Methods of pathomorphological research. 2 Morphological changes of cells as response to stressor and toxic damage 8 (parenchimatouse / intracellular dystrophies). -
The Food Poisoning Toxins of Bacillus Cereus
toxins Review The Food Poisoning Toxins of Bacillus cereus Richard Dietrich 1,†, Nadja Jessberger 1,*,†, Monika Ehling-Schulz 2 , Erwin Märtlbauer 1 and Per Einar Granum 3 1 Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig Maximilian University of Munich, Schönleutnerstr. 8, 85764 Oberschleißheim, Germany; [email protected] (R.D.); [email protected] (E.M.) 2 Department of Pathobiology, Functional Microbiology, Institute of Microbiology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria; [email protected] 3 Department of Food Safety and Infection Biology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, P.O. Box 5003 NMBU, 1432 Ås, Norway; [email protected] * Correspondence: [email protected] † These authors have contributed equally to this work. Abstract: Bacillus cereus is a ubiquitous soil bacterium responsible for two types of food-associated gastrointestinal diseases. While the emetic type, a food intoxication, manifests in nausea and vomiting, food infections with enteropathogenic strains cause diarrhea and abdominal pain. Causative toxins are the cyclic dodecadepsipeptide cereulide, and the proteinaceous enterotoxins hemolysin BL (Hbl), nonhemolytic enterotoxin (Nhe) and cytotoxin K (CytK), respectively. This review covers the current knowledge on distribution and genetic organization of the toxin genes, as well as mechanisms of enterotoxin gene regulation and toxin secretion. In this context, the exceptionally high variability of toxin production between single strains is highlighted. In addition, the mode of action of the pore-forming enterotoxins and their effect on target cells is described in detail. The main focus of this review are the two tripartite enterotoxin complexes Hbl and Nhe, but the latest findings on cereulide and CytK are also presented, as well as methods for toxin detection, and the contribution of further putative virulence factors to the diarrheal disease. -
Te2, Part Iii
TERMINOLOGIA EMBRYOLOGICA Second Edition International Embryological Terminology FIPAT The Federative International Programme for Anatomical Terminology A programme of the International Federation of Associations of Anatomists (IFAA) TE2, PART III Contents Caput V: Organogenesis Chapter 5: Organogenesis (continued) Systema respiratorium Respiratory system Systema urinarium Urinary system Systemata genitalia Genital systems Coeloma Coelom Glandulae endocrinae Endocrine glands Systema cardiovasculare Cardiovascular system Systema lymphoideum Lymphoid system Bibliographic Reference Citation: FIPAT. Terminologia Embryologica. 2nd ed. FIPAT.library.dal.ca. Federative International Programme for Anatomical Terminology, February 2017 Published pending approval by the General Assembly at the next Congress of IFAA (2019) Creative Commons License: The publication of Terminologia Embryologica is under a Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) license The individual terms in this terminology are within the public domain. Statements about terms being part of this international standard terminology should use the above bibliographic reference to cite this terminology. The unaltered PDF files of this terminology may be freely copied and distributed by users. IFAA member societies are authorized to publish translations of this terminology. Authors of other works that might be considered derivative should write to the Chair of FIPAT for permission to publish a derivative work. Caput V: ORGANOGENESIS Chapter 5: ORGANOGENESIS -
Calcinosis Cutis
Dermatology Online Journal UC Davis Calcinosis cutis: A rare feature of adult dermatomyositis Inês Machado Moreira Lobo, Susana Machado, Marta Teixeira, Manuela Selores Dermatology Online Journal 14 (1): 10 Department of Dermatology, Hospital Geral de Santo António, Porto, Portugal. [email protected] Abstract Dermatomyositis is an idiopathic inflammatory myopathy with characteristic cutaneous manifestations. We describe a case of a 55- year-old woman with dermatomyositis who presented with dystrophic calcinosis resistant to medical treatment. Dermatomyositis is an idiopathic inflammatory myopathy with characteristic cutaneous manifestations, including heliotrope rash, Gottron papules, periungual telangiectasias, photodistributed erythema, poikiloderma, and alopecia. Although heliotrope rash and Gottron papules are specific cutaneous features, calcinosis of the skin or muscles is unusual in adults with dermatomyositis. However, it may occur in up to 40 percent of children or adolescents [1]. Calcinosis cutis is the deposition of insoluble calcium salts in the skin. Calcinosis cutis may be divided into four categories according to the pathogenesis as follows: dystrophic, metastatic, idiopathic, and iatrogenic. In connective tissue diseases, calcinosis is mostly of the dystrophic type and it seems to be a localized process rather than an imbalance of calcium homeostasis. Calcium deposits may be intracutaneous, subcutaneous, fascial, or intramuscular. Clinical synopsis A 55-year-old woman was referred for evaluation because of multiple, firm nodules of the lateral hips since 1994. At that time, dermatomyositis was diagnosed based on cutaneous, muscular and pulmonary involvement. The nodules, gradually enlarging since 1999, have begun to cause incapacitation pain and many exude a yellowish material suggestive of calcium. She denied an inciting traumatic event. -
Soft Tissue Calcification and Ossification
Soft Tissue Calcification and Ossification Soft-tissue Calcification Metastatic Calcification =deposit of calcium salts in previously normal tissue (1) as a result of elevation of Ca x P product above 60-70 (2) with normal Ca x P product after renal transplant Location:lung (alveolar septa, bronchial wall, vessel wall), kidney, gastric mucosa, heart, peripheral vessels Cause: (a)Skeletal deossification 1.1° HPT 2.Ectopic HPT production (lung / kidney tumor) 3.Renal osteodystrophy + 2° HPT 4.Hypoparathyroidism (b)Massive bone destruction 1.Widespread bone metastases 2.Plasma cell myeloma 3.Leukemia Dystrophic Calcification (c)Increased intestinal absorption =in presence of normal serum Ca + P levels secondary to local electrolyte / enzyme alterations in areas of tissue injury 1.Hypervitaminosis D Cause: 2.Milk-alkali syndrome (a)Metabolic disorder without hypercalcemia 3.Excess ingestion / IV administration of calcium salts 1.Renal osteodystrophy with 2° HPT 4.Prolonged immobilization 2.Hypoparathyroidism 5.Sarcoidosis 3.Pseudohypoparathyroidism (d)Idiopathic hypercalcemia 4.Pseudopseudohypoparathyroidism 5.Gout 6.Pseudogout = chondrocalcinosis 7.Ochronosis = alkaptonuria 8.Diabetes mellitus (b) Connective tissue disorder 1.Scleroderma 2.Dermatomyositis 3.Systemic lupus erythematosus (c)Trauma 1.Neuropathic calcifications 2.Frostbite 3.Myositis ossificans progressiva 4.Calcific tendinitis / bursitis (d)Infestation 1.Cysticercosis Generalized Calcinosis 2.Dracunculosis (guinea worm) (a)Collagen vascular disorders 3.Loiasis 1.Scleroderma -
71182407Ad80c7abf430b599eb
Journal name: International Journal of Nanomedicine Article Designation: Original Research Year: 2017 Volume: 12 International Journal of Nanomedicine Dovepress Running head verso: Yang et al Running head recto: HA-SPIONs for effective cancer diagnosis and treatment open access to scientific and medical research DOI: http://dx.doi.org/10.2147/IJN.S121249 Open Access Full Text Article ORIGINAL RESEARCH Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy Rui-Meng Yang1,* Abstract: Theranostic nanoparticles with both imaging and therapeutic abilities are highly Chao-Ping Fu2,* promising in successful diagnosis and treatment of the most devastating cancers. In this study, Jin-Zhi Fang1 the dual-modal imaging and photothermal effect of hyaluronan (HA)-modified superparamag- Xiang-Dong Xu1 netic iron oxide nanoparticles (HA-SPIONs), which was developed in a previous study, were Xin-Hua Wei1 investigated for CD44 HA receptor-overexpressing breast cancer in both in vitro and in vivo Wen-Jie Tang1 experiments. Heat is found to be rapidly generated by near-infrared laser range irradiation of HA- SPIONs. When incubated with CD44 HA receptor-overexpressing MDA-MB-231 cells in vitro, Xin-Qing Jiang1 HA-SPIONs exhibited significant specific cellular uptake and specific accumulation confirmed Li-Ming Zhang2 by Prussian blue staining. The in vitro and in vivo results of magnetic resonance imaging and 1Department of Radiology, Guangzhou photothermal ablation demonstrated that HA-SPIONs exhibited significant negative contrast First People’s Hospital, Guangzhou enhancement on T -weighted magnetic resonance imaging and photothermal effect targeted Medical University, 2School of 2 Materials Science and Engineering, CD44 HA receptor-overexpressing breast cancer. -
Evaluation of the Individual and Combined Toxicity of Fumonisin Mycotoxins in Human Gastric Epithelial Cells
International Journal of Molecular Sciences Article Evaluation of the Individual and Combined Toxicity of Fumonisin Mycotoxins in Human Gastric Epithelial Cells Song Yu, Bingxuan Jia, Na Liu, Dianzhen Yu and Aibo Wu * SIBS-UGENT-SJTU Joint Laboratory of Mycotoxin Research, CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; [email protected] (S.Y.); [email protected] (B.J.); [email protected] (N.L.); [email protected] (D.Y.) * Correspondence: [email protected]; Tel.: +86-21-54920716 Received: 23 July 2020; Accepted: 14 August 2020; Published: 18 August 2020 Abstract: Fumonisin contaminates food and feed extensively throughout the world, causing chronic and acute toxicity in human and animals. Currently, studies on the toxicology of fumonisins mainly focus on fumonisin B1 (FB1). Considering that FB1, fumonisin B2 (FB2) and fumonisin B3 (FB3) could coexist in food and feed, a study regarding a single toxin, FB1, may not completely reflect the toxicity of fumonisin. The gastrointestinal tract is usually exposed to these dietary toxins. In our study, the human gastric epithelial cell line (GES-1) was used as in vitro model to evaluate the toxicity of fumonisin. Firstly, we found that they could cause a decrease in cell viability, and increase in membrane leakage, cell death and the induction of expression of markers for endoplasmic reticulum (ER) stress. Their toxicity potency rank is FB1 > FB2 >> FB3. The results also showed that the synergistic effect appeared in the combinations of FB1 + FB2 and FB1 + FB3. -
Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-Tailed Opossum (Monodelphis Domestica) and North American Opossum (Didelphis Virginiana)
University of Tennessee, Knoxville TRACE: Tennessee Research and Creative Exchange Doctoral Dissertations Graduate School 12-2001 Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-tailed Opossum (Monodelphis domestica) and North American Opossum (Didelphis virginiana) Lee Anne Cope University of Tennessee - Knoxville Follow this and additional works at: https://trace.tennessee.edu/utk_graddiss Part of the Animal Sciences Commons Recommended Citation Cope, Lee Anne, "Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-tailed Opossum (Monodelphis domestica) and North American Opossum (Didelphis virginiana). " PhD diss., University of Tennessee, 2001. https://trace.tennessee.edu/utk_graddiss/2046 This Dissertation is brought to you for free and open access by the Graduate School at TRACE: Tennessee Research and Creative Exchange. It has been accepted for inclusion in Doctoral Dissertations by an authorized administrator of TRACE: Tennessee Research and Creative Exchange. For more information, please contact [email protected]. To the Graduate Council: I am submitting herewith a dissertation written by Lee Anne Cope entitled "Comparative Anatomy of the Lower Respiratory Tract of the Gray Short-tailed Opossum (Monodelphis domestica) and North American Opossum (Didelphis virginiana)." I have examined the final electronic copy of this dissertation for form and content and recommend that it be accepted in partial fulfillment of the equirr ements for the degree of Doctor of Philosophy, with a major in Animal Science. Robert W. Henry, Major Professor We have read this dissertation and recommend its acceptance: Dr. R.B. Reed, Dr. C. Mendis-Handagama, Dr. J. Schumacher, Dr. S.E. Orosz Accepted for the Council: Carolyn R. -
University of Bradford Ethesis
University of Bradford eThesis This thesis is hosted in Bradford Scholars – The University of Bradford Open Access repository. Visit the repository for full metadata or to contact the repository team © University of Bradford. This work is licenced for reuse under a Creative Commons Licence. THE IDENTIFICATION OF BOVINE TUBERCULOSIS IN ZOOARCHAEOLOGICAL ASSEMBLAGES VOLUME 1 (1 OF 2) J. E. WOODING PhD UNIVERSITY OF BRADFORD 2010 THE IDENTIFICATION OF BOVINE TUBERCULOSIS IN ZOOARCHAEOLOGICAL ASSEMBLAGES Working towards differential diagnostic criteria Volume 1 (1 of 2) Jeanette Eve WOODING Submitted for the degree of Doctor of Philosophy School of Life Sciences Division of Archaeological, Geographical and Environmental Sciences University of Bradford 2010 Jeanette Eve WOODING The identification of bovine tuberculosis in zooarchaeological assemblages. Working towards differential diagnostic criteria. Keywords: Palaeopathology, zooarchaeology, human osteoarchaeology, zoonosis, Iron Age, Viking Age, Iceland, Orkney, England ABSTRACT The study of human palaeopathology has developed considerably in the last three decades resulting in a structured and standardised framework of practice, based upon skeletal lesion patterning and differential diagnosis. By comparison, disarticulated zooarchaeological assemblages have precluded the observation of lesion distributions, resulting in a dearth of information regarding differential diagnosis and a lack of standard palaeopathological recording methods. Therefore, zoopalaeopathology has been restricted to the analysis of localised pathologies and ‘interesting specimens’. Under present circumstances, researchers can draw little confidence that the routine recording of palaeopathological lesions, their description or differential diagnosis will ever form a standard part of zooarchaeological analysis. This has impeded the understanding of animal disease in past society and, in particular, has restricted the study of systemic disease. -
Vocabulario De Morfoloxía, Anatomía E Citoloxía Veterinaria
Vocabulario de Morfoloxía, anatomía e citoloxía veterinaria (galego-español-inglés) Servizo de Normalización Lingüística Universidade de Santiago de Compostela COLECCIÓN VOCABULARIOS TEMÁTICOS N.º 4 SERVIZO DE NORMALIZACIÓN LINGÜÍSTICA Vocabulario de Morfoloxía, anatomía e citoloxía veterinaria (galego-español-inglés) 2008 UNIVERSIDADE DE SANTIAGO DE COMPOSTELA VOCABULARIO de morfoloxía, anatomía e citoloxía veterinaria : (galego-español- inglés) / coordinador Xusto A. Rodríguez Río, Servizo de Normalización Lingüística ; autores Matilde Lombardero Fernández ... [et al.]. – Santiago de Compostela : Universidade de Santiago de Compostela, Servizo de Publicacións e Intercambio Científico, 2008. – 369 p. ; 21 cm. – (Vocabularios temáticos ; 4). - D.L. C 2458-2008. – ISBN 978-84-9887-018-3 1.Medicina �������������������������������������������������������������������������veterinaria-Diccionarios�������������������������������������������������. 2.Galego (Lingua)-Glosarios, vocabularios, etc. políglotas. I.Lombardero Fernández, Matilde. II.Rodríguez Rio, Xusto A. coord. III. Universidade de Santiago de Compostela. Servizo de Normalización Lingüística, coord. IV.Universidade de Santiago de Compostela. Servizo de Publicacións e Intercambio Científico, ed. V.Serie. 591.4(038)=699=60=20 Coordinador Xusto A. Rodríguez Río (Área de Terminoloxía. Servizo de Normalización Lingüística. Universidade de Santiago de Compostela) Autoras/res Matilde Lombardero Fernández (doutora en Veterinaria e profesora do Departamento de Anatomía e Produción Animal. -
Mycobacterium Tuberculosis Scott M
© 2015. Published by The Company of Biologists Ltd | Disease Models & Mechanisms (2015) 8, 591-602 doi:10.1242/dmm.019570 RESEARCH ARTICLE Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis Scott M. Irwin1, Emily Driver1, Edward Lyon1, Christopher Schrupp1, Gavin Ryan1, Mercedes Gonzalez-Juarrero1, Randall J. Basaraba1, Eric L. Nuermberger2 and Anne J. Lenaerts1,* ABSTRACT reservoir (Lin and Flynn, 2010). Since 2008, the incidence of Cost-effective animal models that accurately reflect the pathological multiple-drug-resistant (MDR) tuberculosis (TB) in Africa has progression of pulmonary tuberculosis are needed to screen and almost doubled, while in southeast Asia the incidence has increased evaluate novel tuberculosis drugs and drug regimens. Pulmonary more than 11 times (World Health Organization, 2013). Globally, disease in humans is characterized by a number of heterogeneous the incidence of MDR TB increased 42% from 2011 to 2012, with lesion types that reflect differences in cellular composition and almost 10% of those cases being extensively drug-resistant (XDR) organization, extent of encapsulation, and degree of caseous TB. With the rise in MDR and XDR TB, new drugs and especially necrosis. C3HeB/FeJ mice have been increasingly used to model drugs with a novel mechanism of action or drugs that can shorten the tuberculosis infection because they produce hypoxic, well-defined duration of treatment are desperately needed. granulomas