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České Budějovice BSP Trypanosomiasis & Leishmaniasis

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České Budějovice BSP Trypanosomiasis & Leishmaniasis České Budějovice BSP Trypanosomiasis & Leishmaniasis Seminar 2016 BIOLOGY CENTRE CAS Czech Academy of Sciences INSTITUTE1 OF PARASITOLOGY University of South Bohemia Two routes from the town centre to the campus The Campus Canteen for Lunch Student Accommodation Bus Stop no. 3 from Railway St. BSP meeting venue Bus Stop no. 3 to Railways St. 2 Dear friends, We are happy to welcome you at the Trypanosomiasis and Leishmaniasis Seminar of the British Society for Parasitology held in České Budějovice, the “capital” of South Bohemia. More of you signed up for it than we expected, which is great and shows that the interest in our favorite protists is not waning. The meeting is organized by the Institute of Parasitology and will be held at the Biology Centre, both part of the Czech Academy of Sciences. The conference site is located on the outskirts of the city (about 90,000 inhabitants), walking distance from the historical centre (~ 25 minutes walk) and is well connected by public transportation. The program will be quite intense, following the traditional single session policy, but there will be enough time for discussions, social events and a party at a chateau just for us. The organizers will do all they can to ensure this is an enjoyable meeting for all of you, and please feel free to contact us with any questions. We look forward to meeting you all during the conference. Best wishes, Julius Lukeš 3 Sunday (September 4) (3:00-5:00) program _____________________________ 5 Plenary (7:00 – 7:40 PM) _______________________________________________________ 5 Monday (September 5) program ______________________________________ 6 Session 1 – Comparative and Population Genomics (9:00 - 11:00 AM) ______________________ 6 Session 2 - Biochemistry and Metabolism (11:25 till 1:00 PM) ____________________________ 6 Session 3 – Host-Parasite Interactions (2:00 till 4:00 PM) _______________________________ 7 Poster Session (4:15 – 6:00 PM) _________________________________________________ 7 Tuesday (September 6) program _____________________________________ 8 Session 3 – Cell Biology (9:00 - 11:00 AM) __________________________________________ 8 Session 2 - Biochemistry and Metabolism (11:25 till 1:00 PM) ____________________________ 8 Session 4 – Gene Expression (2:00 till 4:00 PM) ______________________________________ 9 Wednesday (September 7) program ___________________________________ 9 Session 6 - Interactions in the Field, Epidemiology and Cell Biology (9:00 - 11:00 AM) __________ 9 Session 2 - Cell Biology (11:30 TILL 1:00 PM) ______________________________________ 10 Abstracts ______________________________________________________ 11 Oral Presentations in time order ____________________________________ 11 Sunday (September 4) ____________________________________________ 11 Plenary (7:00 – 7:40 PM) ______________________________________________________ 11 Monday (September 5) ____________________________________________ 12 Session 1 – Comparative and Population Genomics (9:00 - 11:00 AM) _____________________ 12 Session 2 - Biochemistry and Metabolism (11:25 till 1:00 PM) ___________________________ 14 Session 3 – Host-Parasite Interactions (2:00 till 4:00 PM) ______________________________ 16 Tuesday (September 6) ___________________________________________ 19 Session 3 – Cell Biology (9:00 - 11:00 AM) _________________________________________ 19 Session 2 - Biochemistry and Metabolism (11:25 till 1:00 PM) ___________________________ 22 Session 4 – Gene Expression (2:00 till 4:00 PM) _____________________________________ 24 Wednesday (September 7) _________________________________________ 27 Session 6 - Interactions in the Field, Epidemiology and Cell Biology (9:00 - 11:00 AM) _________ 27 Session 2 - Cell Biology (11:30 TILL 1:00 PM) ______________________________________ 30 Posters _______________________________________________________ 33 Index _________________________________________________________ 94 4 Program September 2016 BSP meeting – České Budějovice Sunday (September 4) (3:00-5:00) program Kinetoplast Breeders - Meeting of P.I.’s about joint grant applications, EU calls etc. Mark Carrington Introduction (3:00) Harry de Koning Academic perspective: the PDE4NPD consortium (3:05) David Bailey SME perspective: Building international scientific networks to tackle neglected parasitic diseases: the EU NPD Project as a Case Study (3:30) Coffee Break Gerald Spaeth LeishDrug, LeishRIIP and LeiSHield (4:30) Keith Gull Closing remarks (5:00) Registration (4:00 – 8:00 PM) Plenary (7:00 – 7:40 PM) František Štěpánek (plenary lecture) Remote control of reaction-diffusion processes with chemical microrobots (7:00 – 7:40 PM) Welcome Party (7:50 – 12:00 PM) 5 Monday (September 5) program Session 1 – Comparative and Population Genomics (9:00 - 11:00 AM) Vyacheslav Yurchenko (invited): Comparative genomics of trypanosomatids: identification of novel virulence factors and new insights into evolution of Leishmania (A10575); (9:00 – 9:25) Gerald Spaeth: Asexual maintenance of genetic diversity in Leishmania donovani (A10958);(9:25 – 9:40) Michael Grigg (invited): Extant heterozygosity and genetic hybridization have dramatically impacted "Old World" Leishmania natural population genetics (A10579); (9:40 – 10:05) Malgorzata Domagalska: Genome and transcriptome dynamics throughout the life cycle of Leishmania donovani (A10843); (10:05 -10:20) Louisa Messenger: Pan-American migration promotes the spread of pathogenic Trypanosoma cruzi hybrid strains (A10793); (10:20 – 10:35) Caroline Dewar: What do kinetoplastids need a kinetoplast for? Life cycle progression of Trypanosoma brucei in the presence and absence of mitochondrial DNA (A10625); (10:35 – 10:50) Coffee Break Session 2 - Biochemistry and Metabolism (11:25 till 1:00 PM) David Horn (invited): Decoding antitrypanosomal drug action and resistance (A10577); (11:25 – 11:50) Michal Shapira: A network of cap-binding proteins in the service of stress physiology in trypanosomatids (A10838); (11:50 – 12:05) Martin Taylor (invited): Iron uptake in Trypanosoma brucei (A11141); (12:05 – 12:30) Susanne Kramer: Where is the trypanosome decapping enzyme? (A10673); (12:30 – 12:45) Helena Reis: A novel telomere-binding protein, TelBP1, modulates VSG expression site silencing kinetics in Trypanosoma brucei (A11035); (12:45 – 1:00 PM) (12:45 – 1:00 PM) 6 Lunch (1:00 -2:00 PM) Session 3 – Host-Parasite Interactions (2:00 till 4:00 PM) Matthew Higgins (invited): A receptor’s tale: structural and functional diversification of the trypanosome haptoglobin-haemoglobin receptor (A10578) (2:00 – 2:25 PM) Jayne Raper: Germline transmission of targeted baboon apolipoprotein L-1 in mice protects against African trypanosomes (A11080); (2:25 – 2:40 PM) Steven Kelly (invited): Your genes are what you eat: The metabolic basis of genome composition and codon bias (A10576); (2:40 – 3:05 PM) Elisha Mugo: The RNA binding protein-RBP10 defines bloodstream form trypanosome identity (A11051); (3:05 – 3:20 PM) Thomas Bartossek: The complete structures of VSGs MITat1.1 and ILTat1.24: combining density and mobility through flexibility (A11069); (3:20 – 3:35 PM) Pegine Walrad: Regulating the regulators: LmjPRMT7 in Leishmania parasite virulence and trans-regulator methylation” (A11186); (3:35 – 3:50 PM) Poster Session (4:15 – 6:00 PM) Free Evening 7 Tuesday (September 6) program Session 3 – Cell Biology (9:00 - 11:00 AM) Mark C. Field (invited): Drugs and trafficking in trypanosomes (A10580); (9:00 – 9:25) Lucy Glover: Replication protein A DNA repair foci persist through the cell-cycle and reflect a ‘divide and repair later’ strategy in trypanosomes (A11081); (9:25 – 9:40) Brooke Morriswood (invited): The real flux capacitor? A putative molecular valve in trypanosomes (A10581); (9:40 – 10:05) Olivia J. S. Macleod: Molecular characterization of the complement factor H receptor in the bloodstream and procyclic forms of Trypanosoma brucei (A11132); (10:05 – 10:20) Alena Zíková: Cultured bloodstream Trypanosoma brucei adapt to life without their mitochondrial translation release factor (A11177); (10:20 – 10:35) Tom Beneke: Discovery of new Leishmania motility mutants in a CRISPR-Cas9 knockout screen of the flagellar proteome (A11091); (10:35 – 10:50) Coffee Break Session 2 - Biochemistry and Metabolism (11:25 till 1:00 PM) Paula MacGregor (invited): Exploitation of receptor-mediated ligand uptake for the targeted delivery of antibody- toxin conjugates into Trypanosoma brucei ( A10582); (11:25 – 11:50) Anna Trenaman: The ZC3H39/40 RNA-binding complex and the control of electron transport chain expression in African trypanosomes (A11134); (11:50 – 12:05) Torsten Ochsenreiter (invited): Mitochondrial organelle biogenesis during the cell cycle in Trypanosoma brucei (A10584); (12:05 – 12:30) Priscila Peña-Diaz: A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei (12:30 – 12:45) 8 Zdeněk Paris: Queuosine: The role of an essential tRNA modification in Trypanosoma brucei (A11185); (12:45 – 1:00 PM) Lunch (1:00 -2:00 PM) Session 4 – Gene Expression (2:00 till 4:00 PM) Keith Matthews (invited): Understanding the signalling pathway controlling African trypanosome quorum sensing and life-cycle differentiation (A10583); (2:00 – 2:25 PM) Vladimír Varga: The flagella connector of Trypanosoma brucei is a kinesin-powered junction distinct from the axonemal capping structure (A11158); (2:25 – 2:40 PM) André Schneider: The non-canonical mitochondrial inner membrane protein translocase of trypanosomatids contains
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