USC Fetes Opening of Eli and Edythe Broad CIRM Center

NOVEMBER 5 • 2010 TheWeekly theweekly.usc.edu PUBLISHED FOR THE USC HEALTH SCIENCES CAMPUS COMMUNITY VOLUME 16 • NUMBER 34

‘This is much more than just bricks and mortar. This is an institute of hope—hope for millions of people who suffer from Alzheimer’s, from cancer, from AIDS, from Parkinson’s disease and many other diseases.’

—California Gov. Arnold Schwarzenegger Jon Nalick From left, Keck School of Medicine Dean Carmen A. Puliafito, California Gov. Arnold Schwarzenegger, Broad Foundation founders Edythe and Eli Broad, CIRM Chair Robert Klein and USC President C. L. Max Nikias formally open the new center before a crush of media and a crowd of hundreds of USC staff, faculty and students. USC fetes opening of Eli and Edythe Broad CIRM Center

By Imelda Valenzuela cell research center here at with their research teams will California Gov. Arnold USC,” said Schwarzeneg- expand the frontiers of science Schwarzenegger joined USC ger. “Behind me we see this and medicine in pursuit of administrators, trustees, beautiful building with great life-saving cures.” elected public officials and architecture, but this is much USC President C. L. Max over 150 invited guests in the more than just bricks and Nikias and Keck School of much-anticipated dedication mortar. This is an institute Medicine of USC Dean Car- and ribbon-cutting ceremony of hope—hope for millions men A. Puliafito hosted the for the Eli and Edythe Broad of people who suffer from dedication ceremony. CIRM Center for Regenera- Alzheimer’s, from cancer, Puliafito introduced the tive Medicine and Stem Cell from AIDS, from Parkinson’s governor by recognizing his Research at USC held Oct. 29. disease and many other great courage in supporting “We are all gathering this diseases. Here, 18 of the finest the Stem Cell Research and morning to celebrate the stem scientists in the world along Cures Initiative known as

Proposition 71. “In the fall of Jon Nalick 2004, the future of stem cell Above, broadcast news crews, New center spurs collaboration, research in this country was in photographers and print journalists great peril. It took great cour- gather to cover the event. discoveries and expansion age for the newly elected governor of California to oppose Left (from left), Eli and Edythe Broad and Keck School of Medicine Dean By Carrie St. Michel formation from rendering the policy of his party and Carmen A. Puliafito prepare to take Outwardly, the Eli and to reality, is a fan of both its his President by supporting the stage at the start of the Oct. 29 Edythe Broad CIRM form and function. “With its the Stem Cell Research and ceremony opening the new building. Center for Regenerative black granite and glass, the Cures Initiative. Our governor Medicine and Stem Cell building is very distinctive supported the preservation of potential to revolutionize Research at USC is a and modern looking,” he human life and the reversal of medicine,” said Eli Broad. “I striking, architectural eye- said. “In terms of layout, it’s disability by supporting the truly believe that biotechnol- catcher. From an interior extremely well-suited to the promise of stem cell research.” ogy is one of the areas that are

perspective, facilitating functions of our scientists. Nikias characterized the day Jon Nalick the economic future of this collaboration drove the I think it will be a fantastic as “one of the most momen- city and this state. We want to design, with an eye toward work environment.” tous days in the history of our and Edythe Broad. And they be a magnet for biotech talent catching the immensely And that work—clustered Health Sciences Campus and will see that what we have and business so we all have promising potential of stem under the complex catchall our Keck School of Medi- done together has changed not high expectations for this new cell research. of stem cell research—is cine.” He said, “This new only this university, but also center for stem cell research “I just like the whole the pressing priority shared center carries out our prom- the world.” and regenerative medicine building,” said a sincerely by Pera and the other ise to society. In the future Eli and Edythe Broad, the here at USC.” pleased Martin Pera, profes- preeminent investigators historians will search for the building’s namesakes and Construction of the sor and founding director of who now call the building turning point in the age of primary donors, gave $30 mil- $80 million, five-story, the Eli and Edythe Broad home. Given the inherent medicine and biology. And lion toward its development, 87,500-square-foot, “green”- Center for Regenerative challenges that accompany when they do, they will look which stands as one of the certified building located at Medicine and Stem Cell this ever-evolving field, the to this place, they will look to largest gifts given to the Keck 1425 N. San Pablo Ave. started Research at USC. five-floored, 87,500-square- this time, they will look to this School of Medicine of USC in almost exactly two years ago. Pera, who observed first- foot facility was designed CIRM (California Institute for recent years. The building will house an hand the building’s trans- See CENTER, page 5 Regenerative Medicine) cen- “There’s no question that estimated 200 researchers. ter, and they will look to Eli stem cell research has the See STEM CELL, page 6 NOVEMBER 5 • 2010 Walker Trust continues legacy of aid to Keck students

By Imelda Valenzuela Some $300,0000 in scholarships awarded to 30 Keck School of Medicine of USC students from the George and Zelda Walker Trust were “There’s no celebrated at a reception at the Edmondson Faculty Center on need to tell you Sept. 29. how expensive The students received the scholarships in $10,000 incre- it is to put a ments from the trust. student through George and Zelda Walker both attended USC in the medical school, early 1930s, married, and so whatever we lived in Pasadena. George Walker, who passed away in can do to help 1975, had a successful career in the insurance business, and lower the and, as an insurance provider debt burden for for the California Hospital Association, became closely our students involved with the health care Sara Reeve is extremely industry. It was through this Scholarship recipients meet trustees from the Zelda and George Walker Trust at a reception on campus on Sept. 29. From left David involvement that he and Zelda Larsen, Trustee Gerald Sullivan, Lauren Michelle Friedman, Trustee Eli Dubrow, Neda Roosta, Barbara Danielle Rubino and Crystal important to us.” (who died in 2004) decided to Marie Ives. dedicate a portion of their trust to the Keck School. a student through medical to grant scholarships to these my whole time at USC—it’s — Henri Ford, vice “I stand here mostly to school, so whatever we can talented students, who will almost a full year of tuition,” dean of medical express my sincere gratitude do to help and lower the debt become great physicians and said Ives. education for the on behalf of the entire Keck burden for our students is ex- carry on the Keck legacy,” he She added, “It’s been phe- School family for the generos- tremely important to us,” Ford said. nomenal for me and my hus- Keck School ity and the visionary gift that said. He added that scholar- Keck student Crystal Ives, band because he’s also at USC the Walker Trust has been able ships allow the Keck School to who is in the Dean’s Research studying pharmacy and we’re to provide,” said Henri Ford, be competitive among other Fifth-Year Scholars Program, sort of a double debt family. I vice dean of medical education medical schools, and provide created by Keck School Dean never wanted to have to make for the Keck School and chief the school with the ability to Carmen A. Puliafito, has a choice of what specialty to of surgery, Childrens Hospital better recruit and attract “the received $30,000 in three years go into based on money. I feel Los Angeles, at the event. very best and most talented from the Walker Trust. like I don’t have to. We’ll be “There’s no need to tell students.” “This has been the biggest able to pay back out debt and you how expensive it is to put “This $300,000 allows us scholarship that I’ve received we’ll be ok.” University Kidney Research Organization to honor Keck School Dean Carmen A. Puliafito

University Kidney Research CEO and chairman of the research at the Keck School. Outstanding Achievement in Street Journal’s Marketwatch Organization (UKRO) will board of Fresenius Medical Vaughn A. Starnes, Distin- Business and Industry Award reported in 2009 that Medicare honor Keck School of Medi- Care, for their contributions guished Professor and chair, presented by Michael Lazarus, costs for kidney disease are cine Dean Carmen A. Puliafito and personal commitment to Department of Surgery, at senior executive vice president $72,000 per patient annually. at its annual dinner to fund raise awareness about the im- the Keck School, will present and Emeritus CMO for Fre- Through project grants and kidney research on Friday, portance of research in fighting Dean Puliafito with his award. senius. Under Lipps’ leader- other means, UKRO contrib- Dec. 10, at the Beverly Hilton kidney disease. Cole will receive the Spirit ship, Fresenius has become utes to kidney research at Hotel. “With one in nine adults of Life Award, presented by a worldwide industry leader various institutions throughout UKRO is a Los Angeles– afflicted with some form of Phil McGraw, New York in the production of medical Southern California, and hopes based nonprofit organization kidney disease, it is imperative Times best-selling author and supplies for renal dialysis. to secure contributions suffi- supporting medical research that the nation make kidney daytime television talk show Additionally, Anne Riquier- cient to establish Los Angeles related to the prevention, research a major priority,” said host. Cole received a kidney Brison will receive the John as a center for explorations to treatment and eradication of UKRO president Kenneth transplant in May 2009 after McKay Fellowship in Renal identify the causes, improve all forms of kidney disease. Kleinberg. 10 months on dialysis. She Research at USC. existing treatments, and— Puliafito will be honored Puliafito will receive currently serves as a national Over 26 million people in ultimately—find a cure for all along with singer/songwriter the Leadership Award for spokesperson for UKRO. the United States are believed forms of kidney disease. Natalie Cole and Ben J. Lipps, strengthening and fostering Lipps will receive the to suffer from some type of For tickets or more kidney disease, and millions information, please contact of others are at increased risk, Mann Productions at The according to the National (323) 314-7000 or Mann. Weekly Next Issue: Nov. 12 Kidney Foundation. The Wall [email protected].

The Weekly is published for the faculty, staff, students, volunteers and visitors in the Univer- It’s Not Too Late to Give sity of Southern California’s Health Sciences Campus community. It is written and produced by the Health Sciences Public Relations and Marketing staff. Comments, suggestions and You can still participate in the 2010 Good Neighbors Campaign. More story ideas are welcome. Permission to reprint articles with attribution is freely given. than 5,300 USC faculty and staff members have signed up to date, but more individuals are needed to reach the goal of $1.3 million. While the 2010 Associate Senior Vice President, Health Sciences Public Relations and Marketing: Jane Brust campaign officially ended on Oct. 31, donations are accepted until the end of the year. Have you pledged yet? Executive Director of Communications and Marketing: Ina Fried As of Nov. 1, 2010, these are the figures for this year’s campaign. Editor: Jon Nalick Total Funds Raised to Date: $1,160,000 Contributors: Eva Blaauw, Tania Chatila, Meghan Lewit, Carol Matthieu, Katie Neith, Sara Total Donors: 5,300 Reeve, Leslie Ridgeway and Imelda Valenzuela University-wide Participation: 35% 1% Donors (Trojans giving one percent or more of their salaries): 500 Senior Vice President, University Relations: Martha Harris From 1995-2009, USC faculty and staff have raised more than $11 million Phone: 323-442-2830 Fax: 323-442-2832 E-mail: [email protected] Web: theweekly.usc.edu RSS: http://www.usc.edu/hscw to fund local programs and organizations that enhance our communities. USC hospitals CEO talks shop at Executive Leadership Series

By Tania Chatila demic medical institutions as well, It doesn’t take much to run into like Tufts-New England Medical Mitch Creem, chief executive Center, Beth Israel Deaconess offi cer of USC University Hospital Medical Center and UCLA and USC Norris Cancer Hospital. “It’s about understanding at a He’s often seen walking the deeper level that we all need to hallways of his hospitals, chat- work together,” Creem said, talking ting with employees and greeting about the cooperative effort among visitors at the front door. He hosts staff and physicians to navigate a casual lunches with staff members successful transition. He talked to talk about what’s on their minds. about the importance of reminding He listens to patient concerns and people of their purpose, something “It’s the little welcomes ideas for improvement. that hit home with Bennis. These are the hallmarks of his “It sounds almost trivial, but it’s things that management style, and it’s how he Chatila Tania so crucial to keep people under- keeps his eye on business. USC University Hospital and USC Norris Cancer Hospital Chief Executive Ofﬁ cer Mitch standing what it is that’s impor- matter, the Creem (right) talks about his management style with leadership guru and Marshall School “It’s the little things that matter, of Business professor Warren Bennis. tant,” Bennis said. “After years connections the connections you make with on a job, it’s so easy to just dial in people,” Creem said. “I feel like next stage,” said Creem, who came to the sometimes. You have to remind you make with the biggest cheerleader on Earth. I spend University in June 2008. With Tenet strug- people of the mission. I thought that was people.” every day of my job encouraging, lifting gling with its relationship with USC and its very powerful.” spirits, building hope.” faculty, the University realized its opportu- Creem also emphasized his own personal Creem shared this sentiment along with nity to join the ranks of top tier academia management style—communicating with — Mitch Creem, other valuable leadership insights at an lay within the hospitals, and creating an employees, setting tasks, following through chief executive Oct. 26 Executive Leadership Series event academic medical center of its own. with plans and making staff the number hosted by the USC Professional Develop- Creem went on to explain the host of one priority. “It’s about living and commu- offi cer of USC ment offi ce. The two-hour event attended challenges he faced following the acquisi- nicating your own personal values. … You University Hospital by nearly 150 guests was held at Univer- tion in transitioning 1,600 employees and have to walk the talk,” Creem said. “These and USC Norris sity Park Campus’ Davidson Conference dozens of faculty members from the old hospitals are a community treasure. It is my Center. It highlighted Creem’s 27 years Tenet culture to a new vision for USC job to protect this asset.” Cancer Hospital of management experience in health care, medicine. Morale was low among staff, IT Ed Becker, executive director of the and included a special “fi reside chat” with systems were scattered, the facilities were USC offi ce of Environmental Health and leadership guru and Marshall School of in need of upgrades, and new governance Safety, called Creem’s leadership insights Business professor Warren Bennis. was suddenly in place. “thought-provoking,” and said they held Creem opened the morning discuss- Still, with the help of a new leader- cross-campus value. ing the dynamics before and after USC’s ship team, Creem was able to turn things “Like Mitch mentioned, so much of acquisition of USC University Hospital and around—growing revenue by more than what we do is instinctive and reactionary,” USC Norris Cancer Hospital from Tenet $68 million, increasing admissions, hiring Becker said. “You have to ask yourself, ‘Are Healthcare Corp. on April 1, 2009. more than 600 new employees and recruit- you putting together the story? Is there a “At the time, we were trying to fi gure ing some 27 new faculty physicians. It’s clear, laid out plan?’ You have to make the out how we could propel USC to the something he’d done before at other aca- journey purposeful.”

USC oncologist speaks to President’s Cancer Panel, TEDMED

The President’s Cancer Panel invited David Agus, at the TEDMED conference near San Diego, Calif. themes including the effect of projected shifts in professor of medicine at the Keck School of Medicine TEDMED is a medical technology and health care population demographics on the cancer enterprise, the to present his perspective on critical cancer research conference bringing together physicians, researchers, effect of the environment on cancer risk, promotion of applications at its Oct. 26 meeting in Philadelphia, PA. entertainers and thought leaders to discuss personal healthy lifestyles to reduce cancer risk, and translating Agus, director of the USC Center for Applied and public health. research into effective cancer care. Molecular Medicine and the USC Westside Prostate Agus was one of 12 experts in private and public For the second consecutive year, Agus participated Cancer Center, was chosen to speak to the panel about medicine and research asked to make presentations in the annual TEDMED conference, which took place innovative approaches to cancer research, including his to the President’s Cancer Panel. These experts in from Oct. 26-29 at the Hotel Del Coronado in Coro- work in the fi elds of proteomics and genomics. The biomedicine and technology shared with the panel the nado, Calif. Agus joined an eclectic group of nearly 60 President’s Cancer Panel advises the President of the breakthroughs they have made or see on the horizon, as panelists including Danny Hillis, who has joint appoint- United States in the development and execution of the well as new possibilities for collaboration, funding and ments as a research professor with Keck and the USC National Cancer Program (NCP). The October panel discovery. Viterbi School of Engineering. Hillis, chairman and co- was titled “The Future of Cancer Research: Accelerat- “Proteomics and genomics have the potential to founder of Applied Minds Inc. is working together with ing Scientifi c Innovation.” be signifi cant game-changers in the fi eld of cancer Agus in the USC-based Physical Science-Oncology “I believe we have to go from the ‘understanding research,” said Keck School Dean Carmen A. Puliafi to. Center, established in 2009 by a $16 million, fi ve-year mode’ to the ‘control mode’ in cancer research,” said “The fact that Dr. Agus was asked, in essence, to help award from the National Cancer Institute. Agus. “We don’t have to understand complex emergent advise the President in these areas speaks volumes Other TEDMED panelists included entertainers systems to control them. We need to push innovation, about the value of his expertise.” Ozzy and Sharon Osbourne, architect Frank Gehry, and this panel is a mechanism to do that. I’m honored The panel meets four times every year and submits magician David Blaine and Sanjay Gupta, chief medical that I have been asked to participate.” an annual report to the President with recommenda- correspondent for CNN. Agus followed his appearance before the President’s tions for improvements. Established by the National For information on TEDMED, go to http://www. Cancer Panel by participating in three separate sessions Cancer Act of 1971, the panel has recently discussed tedmed.com/what.

The Weekly NEWSMAKERS

On Oct. 29, CBS News covered the grand open- An Oct. 26 Los Angeles Times article featured a oncology at USC Norris Stephen Sener about com- ing of the Eli and Edythe Broad CIRM Center for study led by professor of preventive medicine and plications that can arise after breast cancer surgery. Regenerative Medicine and Stem Cell Research at director of the USC Childhood Obesity Research KNX Newsradio also interviewed Sener about the USC. KABC-TV, KNBC-TV, KPCC-FM, La Opinion, Center Michael Goran and colleagues, which topic. China Press and Rafu Shimpo (Japanese News) found that high-fructose corn syrup in soda has also covered the event. much more fructose than advertised. NPR, Time, An Oct. 23 Los Angeles Times article noted that The Atlantic, AOL News and the Des Moines professor of orthopaedic surgery Thomas Vang- An Oct. 29 Science article featured director of Register also covered the study. sness volunteers as the team doctor for Garfi eld the USC Norris Comprehensive Cancer Center High School and quoted him about a lack of full- Peter Jones and his research in the fi eld of cancer On Oct. 25, KNBC-TV interviewed professor of time athletic trainers at L.A. high schools. A second epigenetics. clinical surgery and chief of the division of surgical L.A. Times story on the topic also quoted Vangsness. NOVEMBER 5 • 2010 Health care reform offers new opportunities, challenges in Los Angeles

Provisions of the federal Affordable Care Act passed in issues impacting the quality of coverage through Medicaid if remain uninsured. Some com- health care reform law passed March provides an important life in Los Angeles—including they have family incomes less ponents of the Patient Protec- earlier this year will have framework for Los Angeles the economy, immigration, than 133 percent of the federal tion and Affordable Care Act a profound impact on Los and other cities to turn the housing, transportation, poverty level. will take effect in 2010, while Angeles and surrounding com- corner and solve some of these sustainable development and However, undocumented others will be phased in over munities. While more than 1.9 problems,” Cousineau said. health care reform. immigrants are ineligible for the next four years. million residents will become “The law presents a remark- There are currently around most provisions of the new “Additional work needs to eligible for new health insur- able opportunity to improve 2.7 million uninsured resi- law, and will continue to rely be done to improve provider ance options, public hospi- health and reduce health care dents in Los Angeles County, on public hospitals and clinics participation in Medi-Cal, tals and community health disparities in Los Angeles.” Cousineau said. Many will for health care, he said. Safety increase the number of clini- centers will face challenges in Cousineau discussed his benefit from new state-run in- net hospitals, including Los cians practicing in Los Ange- caring for those who remain findings Oct. 5 at the 2010 surance exchanges, signed into Angeles County+USC Medi- les’ underserved communities uninsured, according to a “Los Angeles: State of the law earlier this month by Gov- cal Center, facing reductions and stabilize our system of report by Michael Cousineau, City Report” press conference ernor Arnold Schwarzenegger, in public funding will have to hospitals and health centers,” associate professor of research at California State University, that provide coverage options reorganize to keep newly in- the report concludes. and director of the Center for Los Angeles. The report, for individuals and small busi- sured patients in their system For more information visit Community Health Studies at published by the Pat Brown nesses. The law also enables of care, while retaining the http://www.patbrowninstitute. the Keck School of Medicine. Institute of Public Affairs, uninsured people to obtain capacity to serve those who org. “The good news is that features articles from eight the Patient Protection and regional experts on critical NIH keeps the peer pressure on—by design and tradition

By Ryan Ball led to Walter Reed and his team discovering that The method of deciding which scientific mosquitoes were the carriers. projects get funded by the National Institutes of Scarpa argued that the United States has Calendar of Events Health (NIH) was recently put under a micro- been so successful in biomedical and behavioral scope at the Keck School of Medicine. research, and has produced so many Nobel Prize This Calendar of events is also online at Antonio Scarpa, director of the Center for winners, because the government pays for science, www.usc.edu/hsccalendar for the Health Scientific Review at NIH, offered insight into not scientists or institutions. Researchers are es- Sciences Campus community the process and steps being taken to ensure its sentially contractors who bid in open competition. future. His Oct. 19 presentation, “Challenges and “The only possible source of adequate support Friday, Nov. 5 Opportunities of NIH Peer-Review: A Vision for of medical research is the taxing power of the Ensuring Its Strategic National Value,” was part federal government,” said Scarpa. 11 a.m. Hematology Grand Rounds. “NFkB Signaling in KSHV- of the Dean’s Translational Medicine Seminar Scarpa added that the institution of peer review Associated Malignancies,” Preet Chaudhary, USC. IPT C2J103. Series. is particularly important as the predominant Info: (323) 865-3950 “Peer review is an American discovery, and we diseases facing Americans shift from infectious Tuesday, Nov. 9 should be proud of that,” Scarpa said. He noted to chronic conditions brought on by obesity and that the United States is the only country that other lifestyle factors. He detailed measures being 11:30 a.m. USC Norris Comprehensive Cancer Center Patient uses the process, which originated in 1878 when taken to trim peer review costs and keep the Education Program. “Improving Treatments for Blood Cancers— the U.S. military wanted to buy the best science process viable, including using Telepresence to What You Need to Know to Make Informed Decisions,” Ann Mohr- bacher, USC. NOR Aresty Aud. Info: (310) 846-4704 to fight the spread of yellow fever. The initiative conduct virtual study sections.

Noon. Psychiatry Grand Rounds. “Treatment of Latinos with Schizophrenia,” Alex Kopelowicz, UCLA. ZNI 112. Info: (323) 442-4065

Wednesday, Nov. 10

Noon. ZNI Seminar Series. “Precision and Function of Neuronal Circuits Controlling Motor Behavior,” Silvia Arber, Univ. of Basel. ZNI 112. Info: (323) 442-2144

Friday, Nov. 12

Deadline for Benefits Open Enrollment. For more information, visit http://www.usc.edu/dept/Benefits/print_your_own.html

8:30 a.m. Surgical Grand Rounds. “Genome Censorship: Epige- netic Control in Lung Health and Disease,” Ite A. Laird-Offringa, USC. DOH 100. Info: (323) 442-2506

Tuesday, Nov. 16

Noon. Psychiatry Grand Rounds. “Pharmacotherapy for People with Schizophrenia and Co-occurring Substance Use,” Douglas Noordsy, Dartmouth. ZNI 112. Info: (323) 442-4065

Thursday, Nov. 18

4 p.m. CER Workshop. “Developing NIH Grant Applications,” Steve Moldin, USC. NML East Conference Rm. Info: (213) 740- 6709

Friday, Nov. 19

8 a.m. Pathology and Laboratory Medicine Grand Rounds. “Mo- lecular Pathogenesis of B-cell Lymphoma,” Ryan Phan, UCLA. NOR 7409. Info: (323) 442-1180 Matthieu Photos by Carol DRESSING UP AND GOING OUT—

As part of their annual Halloween parade, children from the USC Childcare Notice: Deadline for calendar submission is 4 p.m. Mon- Center swarmed USC University Hospital, collecting sweets and smiles day to be considered for that week’s issue—although three before stopping at Pappas Quad to show off their costumes. weeks’ advance notice of events is recommended. Please note that timely submission does not guarantee an item will Above, Jaimie Davis, assistant professor of research at the Keck School, be printed. Send calendar items to The Weekly, KAM 400 strolls past the USC Norris Cancer Hospital or fax to (323) 442-2832, or e-mail to [email protected]. with sons Parker and Luke Davis. Entries must include day, date, time, title of talk, first and last name of speaker, affiliation of speaker, location, and a phone Right, “Superman” Dylan Conti and “farmer” David Galaviz march into the number for information. quad to take a break from fleecing adults of their candy to sample one or two of their treats. Or more. CENTER: Designed from the ground up with collaboration in mind

Continued from page 1 pluripotent stem cells (which Stem Cell Research at USC, to give researchers a scientific CIRM-Funded Institutions can become any kind of tissue as a member of the steering leg up. That boost comes in Institution Funds Total in the body) by Wnt proteins. committee that directs a global the form of workspaces that Name Committed Awards The discovery will lead to consortium called the Inter- feature flexibility and facilitate Stanford University $175,862,473 50 improved methods of develop- national Stem Cell Initiative, collaboration. University of California, Los Angeles $133,540,219 39 ing stem cells directly from helped establish the standards Pera, who joined the Keck University of California, San Francisco $110,532,518 35 patients. Also, under the aus- that define a pluripotent stem School of Medicine in 2006 pices of the USC Center for cell. Another major work University of Southern California $86,366,632 26 and brought with him interna- Molecular Pathways and Drug focused on the genetic stabil- tional recognition for his pio- University of California, San Diego $77,177,593 32 Discovery, a joint venture with ity of stem cell lines—a factor neering work in the arena of To date, USC faculty members working at the two main campuses and Childrens the USC Norris Comprehen- that is crucial to their safe use. Hospital Los Angeles have secured $86.3 million in funding, ranking USC fourth among embryonic stem cell research, California institutions in California Institute for Regenerative Medicine funding received. sive Cancer Center, Kahn and Also, Pera served as co-inves- said the space was structured Heinz-Josef Lenz, professor tigator on a successful USC with expansion in mind. of medicine and preven- CIRM Disease Team applica- “As research groups grow, crucial. “The potential of stem strength here at Keck.” tive medicine, are looking tion to develop an embryonic- the layout can accommodate cell research is tremendous, Those strengths—which to uncover drugs that act on stem-cell-based treatment for that. There’s also flexibility in but so are the challenges. have earned USC faculty signaling pathways common to macular degeneration. bench areas,” he notes. “If we We’ve brought together the members more than $86 mil- stem cells in cancer. One drug • Qi-Long Ying, assistant want to convert what are basi- best scientists, and the more lion in CIRM funding—are has entered clinical trials. professor of cell and neuro- cally desks into lab benches, they work together, the more many and already have • Wange Lu, assistant biology, was the first person that can be done fairly easily.” everyone will benefit.” resulted in a wealth of weighty professor of biochemistry and to derive authentic embry- The $80 million building— With synergistic benefits in discoveries published in molecular biology, identified onic stem cells from rats. This which was funded through a mind, the building’s floor plan prestigious journals, includ- a novel mechanism in the breakthrough finding will $30 million gift from the Eli is open and airy. “There’s a lot ing Cancer Research, Cell, Cell regulation and differentiation enable scientists to create and Edythe Broad Foundation of interaction space on every Stem Cell, Developmental Cell, of neural stem cells. These far more effective animal coupled with a $27 million floor, and even out on balco- Nature, Nature Biotechnology, findings could have important models for studying a wide grant awarded by the Califor- nies. The whole second floor and Proceedings of the National implications for regenerative range of diagnoses, including nia Institute for Regenera- is set aside for core labs and Academy of Sciences. Among the medicine and disease thera- cancer, diabetes, hypertension, tive Medicine (CIRM) and collaborative work to support array of findings: pies, because neural stem cells addiction and autoimmune other monies donated through researchers throughout Keck.” • Gregor B. Adams, assistant potentially can be used for diseases. This is a major devel- private philanthropy—also He adds, “It’s also available professor of cell and neurobiol- cell-replacement therapy in opment in stem cell research dedicates interior real estate to researchers university-wide ogy, identified a new signaling patients with Alzheimer’s, Par- because—in many aspects of specifically for stem cell who want to learn stem cell pathway that helps regulate kinson’s, spinal cord injuries biology—rats are much more research must-haves, includ- technologies.” the movement of blood-form- and brain cancer. closely related to humans than ing four core laboratories, as Leveraging those technolo- ing stem cells—a finding that • Francesca Mariani, as- are mice, which until now well as rooms set aside for cell gies are top researchers who provides insight regarding how sistant professor of cell and have been the animal model. culture and microscopy. currently number 10—a total stem cells circulate throughout neurobiology, conducted a Using this technique, Ying While the world of scientific that won’t stay static. “Over the body, insight that may study that forms the founda- additionally was successful in research is frequently fiercely the next couple of years,” said result in more efficient bone tion for future studies focusing achieving targeted, genetic competitive, the recently Pera, “we’ll be adding another marrow transplants. on limb regeneration. modifications. opened stem cell center was half-dozen investigators. We’re • Michael Kahn, Provost’s • Martin Pera, professor The most recent recruits to consciously constructed to fos- particularly looking for trans- professor of medicine and and founding director, Eli Pera’s core group of investiga- ter collaboration. And, as Pera lational researchers who can pharmacy, isolated the mecha- and Edythe Broad Center for tors are Mohamed Pashm- points out, collaboration is work in the areas of clinical nism of action in regulation of Regenerative Medicine and foroush, assistant professor of medicine, and Henry M. Sucov, associate professor of New building incorporates key green technologies biochemistry and molecular biology, cell and neurobiology. By Meghan Lewit Both bring with them heart- Cutting-edge research needs a home development expertise that that’s on the cutting-edge of innovation. they will apply to the emerg- Standing five-stories high, the sleek black ing field of cardiovascular granite and glass Eli and Edythe Broad regenerative medicine. CIRM Center for Regenerative Medicine “Going forward, our stem and Stem Cell Research at USC combines cell research program will fo- aesthetics and function in a way that pushes cus on areas of clinical research the boundaries of design, as well as science. strength at the Keck School, A certified “green” building, the including ophthalmology, 87,500-square-foot center has glass facades gastroenterology, cardiovascu- running the full length of the building. lar medicine, hematology and It is designed to house research teams in oncology,” Pera said. flexible, open lab spaces that are bathed in Commenting on the global natural light. state of stem cell research, The center is the first building on the Pera is unquestionably upbeat. USC Health Sciences Campus to receive “It’s actually quite amazing

a silver Leadership in Energy and Envi- Jon Nalick when you think about it. It ronmental Design (LEED) designation Guests gather for the grand opening ceremony of the Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem has only been a dozen years based on the structure’s unique eco-friendly Cell Research at USC, which boasts eco-friendly features such as copious natural lighting and special insulation systems. since human embryonic stem features. A double-glazed “curtain wall” on cells were discovered, and the east side of the building allows ventila- of-the-art research facility,” said William Marsh, building project yet we are already moving tion in the cavity, reducing heat gain in warmer temperatures and manager for USC Capital Construction Development. “The result into clinical trials. That’s a creating an insulating barrier when it is cool. The west-facing wall is a building that is stunning and incorporates innovative energy- remarkably fast timeframe for uses a special low-iron glass and is fitted with translucent glass fins efficient design.” what is essentially a brand new that block sun glare while still maintaining views to an adjacent The building design is also intended to help stimulate synergy technology.” courtyard. between research disciplines and shared work and social spaces, On a local level, Pera is The glazing system maximizes natural light in both the office and said Ted Hyman, FAIA, partner at Los Angeles-based ZGF Archi- equally enthusiastic. “I’m laboratory environments, while controlling glare and heat gain and tects LLP. The lab space design includes a flexible modular furni- excited about how our program dramatically reducing electrical demand. The building also utilizes ture system and moveable wall partitions. This “neighborhood” lab has grown and the successes an innovative chilled beam HVAC system, which will use water concept allows easy interaction between labs, while creating more individual investigators are instead of air to cool the space, reducing energy consumption by intimate groupings within the open lab plan, Hyman said. having in their research. more than 30 percent and improving the air quality and occupant “The scientific community at the stem cell center will be per- I think USC is in a great comfort within laboratory and office areas. forming highly collaborative research; therefore it is imperative that position to make some “The project team consisting of ZGF Architects and Morley the design approach maximize both the functional flexibility and leading contributions as we go Construction was given a challenge to design and build a state- the collaborative environment,” he said. forward.” NOVEMBER 5 • 2010 Photos by Jon Nalick Left, Gov. Arnold Schwarzenegger, USC President C. L. Max NIkias and Eli Broad walk to the stage for the Oct. 29 ribbon-cutting ceremony. Above Rosa Dilani, histology core manager at the Eli and Edythe Broad CIRM Center, describes the lab’s function to Broad. Also listening in are U.S. Rep. Lucille Roybal-Allard (in purple) and CIRM Chairman Robert Klein (in gray suit). STEM CELL: New center positioned as cornerstone of biomedical research at USC

Continued from page 1 grad students who will work Originally conceived inside the new facility. The in 2005, the project is the ribbon-cutting was followed product of a public-private by a tour of the building’s partnership between the research labs and a luncheon Keck School, The Eli and for invited guests. Edythe Broad Foundation, Other notables in at- and California’s voter- tendance included: U.S. created California Institute Congresswoman Lucille for Regenerative Medicine Roybal-Allard; California State (CIRM). Sen. Art Torres (ret.); Edward “The definition of ‘possible’ Roski, chair, USC Board of has changed,” said Robert Trustees; and USC Trustees Klein, CIRM chairman, Inde- Malcolm Currie, David Lee, pendent Citizens’ Oversight Al Mann, Harlyne Norris and Left, Martin Pera, founding director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC Committee, and author of Lorna Reed. describes the research USC scientists will perform at the center. Right, in an interview with KABC-TV, Gov. Arnold Schwarzeneg- the California ballot initiative The stem cell center is the ger hails the center as a crucial step forward for medicine and for California. that launched CIRM in 2004. first building on the USC “The stem cell revolution Health Sciences Campus to gentic Institute, the USC “As we work together, Los Architects for the project has begun. Let us recognize, receive a silver Leadership in Norris Comprehensive Cancer Angeles can be truly a world- are ZGF Architects. The celebrate and thank the great Energy and Environmental Center and Hospital, and USC class center for regenerative builder is Morley Construction scientists and post-docs and Design (LEED) designa- University Hospital. medicine.” Company. grad students who are the real tion based on the structure’s “You will see today that heroes in this fundamental unique eco-friendly features. our new building is not only a struggle against history’s plight It incorporates an ultra-clear first-class research facility, but USC Health Sciences Public Relations and Marketing Non-Profit Organization of mankind with chronic glass and black granite façade. also a stunning architectural 1975 Zonal Ave. KAM 400 U.S. POSTAGE PAID Los Angeles, CA 90033 University of Southern California disease,” he said. The building is a cor- statement,” said Martin Pera, An estimated 200 people nerstone in the biomedical founding director of the Eli gathered for the outdoor research corridor on USC’s and Edythe Broad Center for ceremonies, including several Health Sciences Campus that Regenerative Medicine and dozen scientists, post-docs and includes the Zilkha Neuro- Stem Cell Research at USC.

Broads’ largesse aims to improve human condition

A child of immigrant parents who instilled medical research across disciplines. him with the values of hard work and educa- The Broads’ approach to philanthropy tion, Eli Broad founded two Fortune 500 extends far beyond simple grant-making. As companies—KB Home and SunAmerica. Now, entrepreneurial visionaries, they seek to create he and his wife, Edythe, devote their time, new institutions and encourage innovative energy and resources to philanthropy. solutions to contemporary challenges. Together, they established The Broad In their adopted hometown of Los An- Foundations to advance entrepreneurship for geles, their philanthropy has catalyzed a the public good in education, science and the biomedical corridor, anchored by the Eli and arts. Edythe Broad CIRM Center for Regenerative In the area of scientific and medical re- Medicine and Stem Cell Research at USC. search, the Broads’ goal is simple: to improve Eli Broad has served on the Keck School of the human condition. Their investments Medicine Board of Overseers since 1999. are focused on human genomics, stem cell The Broads further extended their com- research and inflammatory bowel disease. mitment to accelerating stem cell research In an unprecedented partnership with the through the creation of regenerative medicine In case of an emergency... Massachusetts Institute of Technology, Har- and stem cell centers at UCLA and UCSF. vard University and the Whitehead Institute, The three centers together make California Call the Emergency Information Phone: 213-740-9233 The emergency telephone system can handle 1,400 simultaneous calls. It the Broads created The Eli and Edythe Broad the capital of stem cell research, as the world’s also has a backup system on the East Coast. Institute in Cambridge, Mass., which has leading researchers pursue innovative clinical become the world’s leading genomics insti- approaches to diagnose and cure disease and Visit the USC Web: http://emergency.usc.edu This page will be tute and serves as the model for collaborative treat disabilities and injuries. activated in case of an emergency. Backup Web servers on the East Coast will function if the USC servers are incapacitated.