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Issue Highlights Editors' Note Editorials Volume 116, Issue 1; July 3, 2007,PP. 1-124 Issue Highlights Issue Highlights Circulation 2007 116: 1, doi:10.1161/CIRCULATIONAHA.107.183534 Editors' Note Gary J. Balady and Ravin Davidoff Circulation 2007 116: 2, doi:10.1161/CIRCULATIONAHA.107.184813 Editorials Cardiovascular Biomarkers: Added Value With an Integrated Approach? Wolfgang Koenig Circulation 2007 116: 3 - 5, doi:10.1161/CIRCULATIONAHA.107.707984 The ST-Segment–Elevation Myocardial Infarction Chain of Survival Joseph P. Ornato Circulation 2007 116: 6 - 9, doi:10.1161/CIRCULATIONAHA.107.710970 Original Articles Arrhythmia/Electrophysiology Common NOS1AP Variants Are Associated With a Prolonged QTc Interval in the Rotterdam Study Albert-Jan L.H.J. Aarnoudse, Christopher Newton-Cheh, Paul I.W. de Bakker, Sabine M.J.M. Straus, Jan A. Kors, Albert Hofman, André G. Uitterlinden, Jacqueline C.M. Witteman, and Bruno H.C. Stricker Circulation 2007 116: 10 - 16; published online before print June 18 2007, doi:10.1161/CIRCULATIONAHA.106.676783 Nonsense Mutations in hERG Cause a Decrease in Mutant mRNA Transcripts by Nonsense-Mediated mRNA Decay in Human Long-QT Syndrome Qiuming Gong, Li Zhang, G. Michael Vincent, Benjamin D. Horne, and Zhengfeng Zhou Circulation 2007 116: 17 - 24; published online before print June 18 2007, doi:10.1161/CIRCULATIONAHA.107.708818 Coronary Heart Disease Coronary Artery Calcification Progression Is Heritable Andrea E. Cassidy-Bushrow, Lawrence F. Bielak, Patrick F. Sheedy, II, Stephen T. Turner, Iftikhar J. Kullo, Xihong Lin, and Patricia A. Peyser Circulation 2007 116: 25 - 31; published online before print June 11 2007, doi:10.1161/CIRCULATIONAHA.106.658583 Epidemiology Association of Carotid Artery Intima-Media Thickness, Plaques, and C-Reactive Protein With Future Cardiovascular Disease and All-Cause Mortality: The Cardiovascular Health Study Jie J. Cao, Alice M. Arnold, Teri A. Manolio, Joseph F. Polak, Bruce M. Psaty, Calvin H. Hirsch, Lewis H. Kuller, and Mary Cushman Circulation 2007 116: 32 - 38; published online before print June 18 2007, doi:10.1161/CIRCULATIONAHA.106.645606 Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study Caroline S. Fox, Joseph M. Massaro, Udo Hoffmann, Karla M. Pou, Pal Maurovich-Horvat, Chun-Yu Liu, Ramachandran S. Vasan, Joanne M. Murabito, James B. Meigs, L. Adrienne Cupples, Ralph B. D’Agostino, Sr, and Christopher J. O’Donnell Circulation 2007 116: 39 - 48; published online before print June 18 2007, doi:10.1161/CIRCULATIONAHA.106.675355 Heart Failure Metoprolol Reverses Left Ventricular Remodeling in Patients With Asymptomatic Systolic Dysfunction: The REversal of VEntricular Remodeling with Toprol-XL (REVERT) Trial Wilson S. Colucci, Theodore J. Kolias, Kirkwood F. Adams, William F. Armstrong, Jalal K. Ghali, Stephen S. Gottlieb, Barry Greenberg, Michael I. Klibaner, Marrick L. Kukin, Jennifer E. Sugg on behalf of the REVERT Study Group Circulation 2007 116: 49 - 56; published online before print June 18 2007, doi:10.1161/CIRCULATIONAHA.106.666016 Negative Inotropy of the Gastric Proton Pump Inhibitor Pantoprazole in Myocardium From Humans and Rabbits: Evaluation of Mechanisms Wolfgang Schillinger, Nils Teucher, Samuel Sossalla, Sarah Kettlewell, Carola Werner, Dirk Raddatz, Andreas Elgner, Gero Tenderich, Burkert Pieske, Giuliano Ramadori, Friedrich A. Schöndube, Harald Kögler, Jens Kockskämper, Lars S. Maier, Harald Schwörer, Godfrey L. Smith, and Gerd Hasenfuss Circulation 2007 116: 57 - 66; published online before print June 18 2007, doi:10.1161/CIRCULATIONAHA.106.666008 Interventional Cardiology Emergency Department Physician Activation of the Catheterization Laboratory and Immediate Transfer to an Immediately Available Catheterization Laboratory Reduce Door-to-Balloon Time in ST-Elevation Myocardial Infarction Umesh N. Khot, Michele L. Johnson, Curtis Ramsey, Monica B. Khot, Randall Todd, Saeed R. Shaikh, and William J. Berg Circulation 2007 116: 67 - 76; published online before print June 11 2007, doi:10.1161/CIRCULATIONAHA.106.677401 Contemporary Reviews in Cardiovascular Medicine The Brain–Heart Connection Martin A. Samuels Circulation 2007 116: 77 - 84, doi:10.1161/CIRCULATIONAHA.106.678995 Cardiovascular Involvement in General Medical Conditions Chronic Kidney Disease: Effects on the Cardiovascular System Ernesto L. Schiffrin, Mark L. Lipman, and Johannes F.E. Mann Circulation 2007 116: 85 - 97, doi:10.1161/CIRCULATIONAHA.106.678342 ACCF/AHA/SCAI Clinical Competence Statement ACCF/AHA/SCAI 2007 Update of the Clinical Competence Statement on Cardiac Interventional Procedures: A Report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and Training (Writing Committee to Update the 1998 Clinical Competence Statement on Recommendations for the Assessment and Maintenance of Proficiency in Coronary Interventional Procedures) Circulation 2007 116: 98 - 124; published online before print June 25 2007, doi:10.1161/CIRCULATIONAHA.107.185159 Images in Cardiovascular Medicine An Unusual Site for a Common Disease Maysaa Alzetani, Joseph J. Boyle, David Lefroy, and Petros Nihoyannopoulos Circulation 2007 116: e1, doi:10.1161/CIRCULATIONAHA.106.677120 Sine-Wave Pattern Arrhythmia and Sudden Paralysis That Result From Severe Hyperkalemia Maurice J.H.M. Pluijmen and Ferry M.R.J. Hersbach Circulation 2007 116: e2 - e4, doi:10.1161/CIRCULATIONAHA.106.687202 Lipomatous Metaplasia in Ischemic Cardiomyopathy: A Common but Unappreciated Entity Matthias Schmitt, Nilesh Samani, and Gerry McCann Circulation 2007 116: e5 - e6, doi:10.1161/CIRCULATIONAHA.107.690800 Correspondence Letter by Brewster and van Montfrans Regarding Article, "Risks Associated With Statin Therapy: A Systematic Overview of Randomized Clinical Trials" Lizzy M. Brewster and Gert A. van Montfrans Circulation 2007 116: e7, doi:10.1161/CIRCULATIONAHA.107.689497 Letter by Rosenberg and Uretsky Regarding Article, "Risks Associated With Statin Therapy: A Systematic Overview of Randomized Clinical Trials" Lauren Rosenberg and Seth Uretsky Circulation 2007 116: e8, doi:10.1161/CIRCULATIONAHA.107.690867 Response to Letters Regarding Article, "Risks Associated With Statin Therapy: A Systematic Overview of Randomized Clinical Trials" Amir Kashani, JoAnne M. Foody, Yongfei Wang, Harlan M. Krumholz, Christopher O. Phillips, Sandeep Mangalmurti, and Dennis T. Ko Circulation 2007 116: e9, doi:10.1161/CIRCULATIONAHA.107.697227 Acknowledgment of Reviewers Acknowledgment of Reviewers Circulation 2007 116: e10 - e21, doi:10.1161/CIRCULATIONAHA.107.184814 News From the American Heart Association News From the American Heart Association Circulation 2007 116: 1B - 2B, doi:10.1161/CIRCULATIONAHA.107.184673 Meetings Calendar Meetings Calendar Circulation 2007 116: 3B - 4B, doi:10.1161/CIRCULATIONAHA.107.184672 American Heart Association Newly Elected Fellows, Spring 2007 American Heart Association Newly Elected Fellows, Spring 2007 Circulation 2007 116: 5B - 6B, doi:10.1161/CIRCULATIONAHA.107.184674 European Perspectives European Perspectives Circulation 2007 116: 1F - 6F, doi:10.1161/CIRCULATIONAHA.107.185417 IIssssuuee HHiigghhlliigghhttss Vol 116, No 1, July 3, 2007 ASSOCIATION OF CAROTID ARTERY INTIMA-MEDIA EMERGENCY DEPARTMENT PHYSICIAN ACTIVATION THICKNESS, PLAQUES, AND C-REACTIVE PROTEIN OF THE CATHETERIZATION LABORATORY AND WITH FUTURE CARDIOVASCULAR DISEASE AND IMMEDIATE TRANSFER TO AN IMMEDIATELY ALL-CAUSE MORTALITY: THE CARDIOVASCULAR AVAILABLE CATHETERIZATION LABORATORY HEALTH STUDY, by Cao et al. REDUCE DOOR-TO-BALLOON TIME IN ST-ELEVATION There is increasing interest in methods to risk-stratify individuals’ risk for MYOCARDIAL INFARCTION, by Khot et al. cardiovascular disease. Cao et al examined the ability of C-reactive protein Guidelines recommend that hospitals strive to achieve a door-to-balloon concentrations with or without carotid intima-media thickness and carotid time within 90 minutes based upon considerable observational data. plaques to predict incident cardiovascular events and death in about 5000 Currently, most hospitals are not achieving this goal. National efforts are elderly participants in the Cardiovascular Health Study. The investigators now under way to improve the door-to-balloon times, but the impact of report that C-reactive protein was not prognostically useful without these efforts has not been prospectively evaluated. In this prospective evidence of carotid atherosclerosis. However, they observed an interaction observational study, the impact of a protocol mandating that the between C-reactive protein and carotid disease; increasing C-reactive emergency department physician activate the cardiac catheterization protein concentrations were associated with a 72% and 52% increased risk laboratory and transfer the patient immediately to the laboratory was of cardiovascular death and all-cause mortality, respectively, in the setting evaluated and compared with the door-to-balloon times achieved prior of carotid atheroslerosis. Similar to other studies, as assessed by the c to the institution of the protocol. This study by Khot et al showed that statistic, both C-reactive protein and carotid atherosclerosis added only door-to-balloon times decreased significantly from 113.5 minutes to modest incremental information to standard cardiovascular disease risk 75.5 minutes after adoption of the protocol. Treatment within 90 factors. The study underscores the need
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