Headline Discoveries Jul-Sep 2015; Issue 3
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Guardant Health, Inc. Form 8-K Current Event Report Filed 2019-01
SECURITIES AND EXCHANGE COMMISSION FORM 8-K Current report filing Filing Date: 2019-01-07 | Period of Report: 2019-01-07 SEC Accession No. 0001628280-19-000132 (HTML Version on secdatabase.com) FILER Guardant Health, Inc. Mailing Address Business Address 505 PENOBSCOT DR. 505 PENOBSCOT DR. CIK:1576280| IRS No.: 454139254 | State of Incorp.:DE | Fiscal Year End: 1231 REDWOOD CITY CA 94063 REDWOOD CITY CA 94063 Type: 8-K | Act: 34 | File No.: 001-38683 | Film No.: 19512177 855-698-8887 SIC: 8071 Medical laboratories Copyright © 2019 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): January 7, 2019 GUARDANT HEALTH, INC. (Exact name of registrant as specified in its charter) Delaware 0001-576280 45-4139254 (State or other jurisdiction (Commission (I.R.S. Employer of incorporation or organization) File Number) Identification No.) 505 Penobscot Dr. Redwood City, California 94063 (Address of principal executive offices) (Zip Code) 855-698-8887 (Registrant’s telephone number, include area code) N/A (Former Name or Former Address, if Changed Since Last Report) Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: ¨ Written communications pursuant to Rule 425 under -
Insights from the Molecular Docking of Withanolide Derivatives to The
open access www.bioinformation.net Hypothesis Volume 10(9) The conserved mitochondrial gene distribution in relatives of Turritopsis nutricula, an immortal jellyfish Pratap Devarapalli1, 2, Ranjith N. Kumavath1*, Debmalya Barh3 & Vasco Azevedo4 1Department of Genomic Science, Central University of Kerala, Riverside Transit Campus, Opp: Nehru College of Arts and Science, NH 17, Padanakkad, Nileshwer, Kasaragod, Kerala-671328, INDIA; 2Genomics & Molecular Medicine Unit, Institute of Genomics and Integrative Biology Council of Scientific and Industrial Research, Mathura Road, New Delhi-110025, INDIA; 3Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, PurbaMedinipur, West Bengal-721172, INDIA; 4Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais. MG, Brazil; Ranjith N. Kumavath - Email: [email protected]; *Corresponding author Received August 14, 2014; Accepted August 16, 2014; Published September 30, 2014 Abstract: Turritopsis nutricula (T. nutricula) is the one of the known reported organisms that can revert its life cycle to the polyp stage even after becoming sexually mature, defining itself as the only immortal organism in the animal kingdom. Therefore, the animal is having prime importance in basic biological, aging, and biomedical researches. However, till date, the genome of this organism has not been sequenced and even there is no molecular phylogenetic study to reveal its close relatives. Here, using phylogenetic analysis based on available 16s rRNA gene and protein sequences of Cytochrome oxidase subunit-I (COI or COX1) of T. nutricula, we have predicted the closest relatives of the organism. While we found Nemopsis bachei could be closest organism based on COX1 gene sequence; T. dohrnii may be designated as the closest taxon to T. -
Headline Discoveries Nov/Dec 2011; Issue 4
Special Report: 12 Months of Science – See What’s Going on Each Month Making Science Matter® HEADLINE DISCOVERIES Nov/Dec 2011; Issue 4 2012 CONFERENCE SUMMARY 2012 CALENDAR THE OLYMPICS GETS TECHNICAL GOING NUCLEAR PI IN THE EYE Download the FREE QR Code Scanner application for your Smartphone and snap this code to view a digital version of Headline Discoveries on our website! What are these codes? Please visit www.thermoscientific.com/codes Inside This Issue: CONFERENCE SUMMARY ...............................................................................................................................3 SUPPLIER INDEX ...................................................................................................................................................3 JANUARY ....................................................................................................................................................................4 FEBRUARY .................................................................................................................................................................4 MARCH .........................................................................................................................................................................6 APRIL .............................................................................................................................................................................7 M AY ................................................................................................................................................................................8 -
Celebrating DNA Day 2015: Engaging Teachers to Inspire Students
April 7, 2015 Spring brings a welcome increase in temperatures (and decrease in snowfall!), as well as other changes around NIH. At the end of March, my friend and colleague, Dr. Harold Varmus, ended his tenure as Director of the National Cancer Institute. I have had the pleasure of collaborating with Harold on joint NCI-NHGRI efforts [most notably The Cancer Genome Atlas (TCGA)] and learning from him around the Institute/Center Director’s table. We have also enjoyed having the Varmus research laboratory within the NHGRI Intramural Research Program. His scientific leadership has been invaluable to NCI and NIH, and we wish him all the best in his future endeavors in New York City. Also of note, I just returned from The Tech Museum of Innovation in San Jose, California, where I joined several leading Bay Area genomics leaders for an engaging public program entitled “Big Data, Genomics, and Precision Medicine.” The exhibition Genome: Unlocking Life’s Code is still on display in San Jose, and it will remain there until the end of this month, after which it will travel to my hometown of St. Louis, Missouri. We look forward to additional future events associated with the exhibition as it travels across North America. April’s The Genomics Landscape features stories about: Celebrating DNA Day 2015: Engaging Teachers to Inspire Students NIH Workshop on Building a Precision Medicine Research Cohort: Meeting Report NIH Position on Cloud Computing and Genomics Data Senator Ben Cardin Recognizes NHGRI Clinical Director Dr. William Gahl Pi Day -
Huzzah to the Double Helix! It's International DNA Day | Lifehacker
Huzzah To The Double Helix! It’s International DNA Day | L... http://www.lifehacker.com.au/2013/04/huzzah-to-the-double-h... Business Insider Gizmodo Kotaku Lifehacker PopSugar BellaSugar FabSugar ShopStyle Log In Register Life Work IT Pro RECENTLY ON KOTAKU RECENTLY ON KOTAKU Robin Has A Point In These Hilarious Conference Or Not, We’ll Cherish Superhero Texts These E3 Nintendo Memes Forever HOME Huzzah To The Double Helix! It’s International DNA Day CHRIS JAGER YESTERDAY 9:30 AM Share 5858 Discuss 22 Today is International DNA Day, which this year commemorates 60 years since the scientific paper A Structure for Deoxyribose Nucleic Acid was first published. Here’s what some of Australia’s leading scientists SUBSCRIBE have to say about the importance of the discovery… CONTACT DNA picture from Shutterstock Sixty years ago to the day, James Watson and Francis Crick published a revolutionary paper on the Like Lifehacker Australia 5,616 Followers structure of Deoxyribonucleic acid; the molecular key to all living things otherwise known as DNA. A Follow Lifehacker Australia 11,734 Followers century after Gregor Mendel first began messing about with peas, the final piece of the genetic puzzle had been slotted into place. Subscribe to all stories 15,269 Followers To mark this historic occasion, several Australian scientists have released statements in which they Australian stories 1,859 Followers basically wax lyrical about the wonders of DNA — what better way to start your morning? (And if you’re wondering what the Lifehacker angle is, the answer is quite simple: when someone smarter than you has something to say, it’s usually worth listening!) REGULARS LIFE Professor Suzanne Cory, President of the Australian Academy of Science: Sell Your Stuff And Get Some Extra Cash This Weekend The discovery of the structure of DNA by James Watson and Francis Crick was an epic moment in the history of science. -
Guardant Health, Inc. Form 10-Q Quarterly Report Filed 2021-08-05
SECURITIES AND EXCHANGE COMMISSION FORM 10-Q Quarterly report pursuant to sections 13 or 15(d) Filing Date: 2021-08-05 | Period of Report: 2021-06-30 SEC Accession No. 0001576280-21-000080 (HTML Version on secdatabase.com) FILER Guardant Health, Inc. Mailing Address Business Address 505 PENOBSCOT DR. 505 PENOBSCOT DR. CIK:1576280| IRS No.: 454139254 | State of Incorp.:DE | Fiscal Year End: 1231 REDWOOD CITY CA 94063 REDWOOD CITY CA 94063 Type: 10-Q | Act: 34 | File No.: 001-38683 | Film No.: 211148786 855-698-8887 SIC: 8071 Medical laboratories Copyright © 2021 www.secdatabase.com. All Rights Reserved. Please Consider the Environment Before Printing This Document UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 _____________________ FORM 10-Q _____________________ (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38683 _____________________ GUARDANT HEALTH, INC. (Exact Name of Registrant as Specified in its Charter) _____________________ Delaware 45-4139254 (State or other jurisdiction of (I.R.S. Employer incorporation or organization) Identification No.) 505 Penobscot Dr. Redwood City, California, 94063 Registrant’s telephone number, including area code: (855) 698-8887 _______________ Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. -
111 Turritopsis Dohrnii Primarily from Wikipedia, the Free Encyclopedia
Turritopsis dohrnii Primarily from Wikipedia, the free encyclopedia (https://en.wikipedia.org/wiki/Dark_matter) Mark Herbert, PhD World Development Institute 39 Main Street, Flushing, Queens, New York 11354, USA, [email protected] Abstract: Turritopsis dohrnii, also known as the immortal jellyfish, is a species of small, biologically immortal jellyfish found worldwide in temperate to tropic waters. It is one of the few known cases of animals capable of reverting completely to a sexually immature, colonial stage after having reached sexual maturity as a solitary individual. Others include the jellyfish Laodicea undulata and species of the genus Aurelia. [Mark Herbert. Turritopsis dohrnii. Stem Cell 2020;11(4):111-114]. ISSN: 1945-4570 (print); ISSN: 1945-4732 (online). http://www.sciencepub.net/stem. 5. doi:10.7537/marsscj110420.05. Keywords: Turritopsis dohrnii; immortal jellyfish, biologically immortal; animals; sexual maturity Turritopsis dohrnii, also known as the immortal without reverting to the polyp form.[9] jellyfish, is a species of small, biologically immortal The capability of biological immortality with no jellyfish[2][3] found worldwide in temperate to tropic maximum lifespan makes T. dohrnii an important waters. It is one of the few known cases of animals target of basic biological, aging and pharmaceutical capable of reverting completely to a sexually immature, research.[10] colonial stage after having reached sexual maturity as The "immortal jellyfish" was formerly classified a solitary individual. Others include the jellyfish as T. nutricula.[11] Laodicea undulata [4] and species of the genus Description Aurelia.[5] The medusa of Turritopsis dohrnii is bell-shaped, Like most other hydrozoans, T. dohrnii begin with a maximum diameter of about 4.5 millimetres their life as tiny, free-swimming larvae known as (0.18 in) and is about as tall as it is wide.[12][13] The planulae. -
TRANSDIFFERENTATION in Turritopsis Dohrnii (IMMORTAL JELLYFISH)
TRANSDIFFERENTATION IN Turritopsis dohrnii (IMMORTAL JELLYFISH): MODEL SYSTEM FOR REGENERATION, CELLULAR PLASTICITY AND AGING A Thesis by YUI MATSUMOTO Submitted to the Office of Graduate and Professional Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Chair of Committee, Maria Pia Miglietta Committee Members, Jaime Alvarado-Bremer Anja Schulze Noushin Ghaffari Intercollegiate Faculty Chair, Anna Armitage December 2017 Major Subject: Marine Biology Copyright 2017 Yui Matsumoto ABSTRACT Turritopsis dohrnii (Cnidaria, Hydrozoa) undergoes life cycle reversal to avoid death caused by physical damage, adverse environmental conditions, or aging. This unique ability has granted the species the name, the “Immortal Jellyfish”. T. dohrnii exhibits an additional developmental stage to the typical hydrozoan life cycle which provides a new paradigm to further understand regeneration, cellular plasticity and aging. Weakened jellyfish will undergo a whole-body transformation into a cluster of uncharacterized tissue (cyst stage) and then metamorphoses back into an earlier life cycle stage, the polyp. The underlying cellular processes that permit its reverse development is called transdifferentiation, a mechanism in which a fully mature and differentiated cell can switch into a new cell type. It was hypothesized that the unique characteristics of the cyst would be mirrored by differential gene expression patterns when compared to the jellyfish and polyp stages. Specifically, it was predicted that the gene categories exhibiting significant differential expression may play a large role in the reverse development and transdifferentiation in T. dohrnii. The polyp, jellyfish and cyst stage of T. dohrnii were sequenced through RNA- sequencing, and the transcriptomes were assembled de novo, and then annotated to create the gene expression profile of each stage. -
CNIDARIA Corals, Medusae, Hydroids, Myxozoans
FOUR Phylum CNIDARIA corals, medusae, hydroids, myxozoans STEPHEN D. CAIRNS, LISA-ANN GERSHWIN, FRED J. BROOK, PHILIP PUGH, ELLIOT W. Dawson, OscaR OcaÑA V., WILLEM VERvooRT, GARY WILLIAMS, JEANETTE E. Watson, DENNIS M. OPREsko, PETER SCHUCHERT, P. MICHAEL HINE, DENNIS P. GORDON, HAMISH J. CAMPBELL, ANTHONY J. WRIGHT, JUAN A. SÁNCHEZ, DAPHNE G. FAUTIN his ancient phylum of mostly marine organisms is best known for its contribution to geomorphological features, forming thousands of square Tkilometres of coral reefs in warm tropical waters. Their fossil remains contribute to some limestones. Cnidarians are also significant components of the plankton, where large medusae – popularly called jellyfish – and colonial forms like Portuguese man-of-war and stringy siphonophores prey on other organisms including small fish. Some of these species are justly feared by humans for their stings, which in some cases can be fatal. Certainly, most New Zealanders will have encountered cnidarians when rambling along beaches and fossicking in rock pools where sea anemones and diminutive bushy hydroids abound. In New Zealand’s fiords and in deeper water on seamounts, black corals and branching gorgonians can form veritable trees five metres high or more. In contrast, inland inhabitants of continental landmasses who have never, or rarely, seen an ocean or visited a seashore can hardly be impressed with the Cnidaria as a phylum – freshwater cnidarians are relatively few, restricted to tiny hydras, the branching hydroid Cordylophora, and rare medusae. Worldwide, there are about 10,000 described species, with perhaps half as many again undescribed. All cnidarians have nettle cells known as nematocysts (or cnidae – from the Greek, knide, a nettle), extraordinarily complex structures that are effectively invaginated coiled tubes within a cell. -
Compendium of Lbnl Divisions' Diversity Activities
COMPENDIUM OF LBNL DIVISIONS’ DIVERSITY ACTIVITIES (FISCAL YEAR 2008) INTRODUCTION ....................................................................................................................................... ix A. Summary of Strategic Recruitment Practices .......................................................................................... 3 B. Summary of Strategic Retention Practices ............................................................................................... 5 C. Summary of Strategic Pipeline and Mentoring ........................................................................................ 6 D. Summary of Training and Education Practices ..................................................................................... 11 1. Strategic Recruitment Activities ............................................................................................................. 13 a. Suitable Search .................................................................................................................................... 13 i. Chemical Sciences ........................................................................................................................... 13 ii. Computing Sciences ....................................................................................................................... 13 iii. Earth Sciences ............................................................................................................................... 13 iv. EETD ............................................................................................................................................ -
History of Bills and Resolutions 10–1
HISTORY OF BILLS AND RESOLUTIONS 10–1 No. Index Key and History of Bill No. Index Key and History of Bill HOUSE CONCURRENT RESOLUTIONS HOUSE CONCURRENT RESOLUTIONS—Continued H. Con. Res. 1.—Regarding consent to assemble outside H. Con. Res. 34.—Expressing the sense of the Congress the seat of government. Passed House Jan. 7, 2003. that private health insurance companies should take Received in Senate Jan. 9, 2003. Passed Senate Feb. a proactive role in promoting healthy lifestyles, and 13, 2003. for other purposes. Referred to Energy and Commerce Feb. 12, 2003. Rules suspended. Passed House amend- H. Con. Res. 6.—Supporting the goals and ideals of ed Oct. 5, 2004. Received in Senate Oct. 6, 2004. Chronic Obstructive Pulmonary Disease Awareness Month. Referred to Government Reform Jan. 7, 2003. H. Con. Res. 35 (H. Res. 71) (H.J. Res. 2).—Directing Rules suspended. Passed House July 16, 2003; Roll the Clerk of the House of Representatives to make No. 374: 428–0. Received in Senate and referred to a technical correction in the enrollment of H.J. Res. Health, Education, Labor, and Pensions July 17, 2003. 2. Referred to Appropriations and in addition to House Administration Feb. 12, 2003. Passed House pursuant H. Con. Res. 8.—Providing for an adjournment or recess to H. Res. 71 Feb. 13, 2003. Received in Senate and of the two Houses. Passed House Jan. 8, 2003. Re- passed Feb. 13, 2003. ceived in Senate and passed Jan. 9, 2003. H. Con. Res. 36 (S. Con. Res. 15).—Encouraging the peo- H. Con. -
Johns Hopkins CTY 2020 Report of Giving & Gratitude
2020 REPORT OF GIVING & GRATITUDE July 1, 2019-June 30, 2020 DEAR CTY FAMILIES AND FRIENDS, CTY Advisory Council Lee Stephens, Chair Since my arrival at the Johns Hopkins Center for Talented Youth Roseana Auten (CTY) in August I have been immersed in conversations with staff, Noriko Honda Chen parents, and alumni, many of whom are also CTY donors. I want Allison Devore to express my deepest thanks to all of you for your thoughtful Lauren Geller support of CTY. It is a pleasure to acknowledge that CTY has touched Peter Hammack the lives of you and your family in an important way, and your Mary Bloom Hyman partnership and confidence in our mission are greatly appreciated. Ronald N. Kahn Terri Kim Philanthropy is essential for CTY to continue to build upon its core Mali Kinberg strengths of talent identification and educational enrichment. Nina Kleaveland Curriculum development, mental health and wellness initiatives, James M. Li research, technology, teacher training, and student financial aid are Marjorie P. Loeb John M. Lutz all greatly enhanced by your donations. Laura Overdeck The COVID-19 pandemic created unexpected financial challenges Ming Jack Po at CTY, but support from parents and alumni around the world, Margret Schmidt thus far, has allowed us to introduce an online version of the School Marc Schneider Jesse J. Wu and College Ability Test (S.C.A.T.), expand enrollments in our Online Shirley L. Zanton Programs, and launch new virtual learning opportunities. Dr. Amy Shelton, CTY Director of Research, provided exceptional leadership CTY East Asia Advisory Council through the early months of this historically disruptive period, and I Oliver Weisberg, Chair am particularly grateful for her hard work and dedication.