Performance Report 2017

Department of Pathophysiology & Allergy Research

Center of Pathophysiology, Infectiology and Immunology Medical University Vienna

Coordinated by: Marion Sack

Content Page

Introduction 3 Organigram 7 Personnel 10

Impulsseminare 11

1.Detailed Reports of Divisions 13 1.1.Division for Comparative Immunology and Oncology 13 1.2.Division for Cellular and Molecular Pathophysiology 53 1.3.Division for Immunopathology 75 1.4.Division for Medical Biotechnology 109 1.5.Division for Allergy Research 127 Rooms 141

Science is the great antidote to the poison of enthusiasm and superstition.

Adam Smith ______

It is my great pleasure to introduce this performance report of the Institute of Pathophysiology and Allergy Research (IPA), which summarizes our scientific and academic achievements in 2017. I wish to express my sincere gratitude to all who made a contribution to this year´s excellent performance! I also congratulate each of you to personal achievements that you have accomplished in 2017! Together, we have maintained our high standards and quality in terms of research performance and academic teaching. The regular meetings of the group leaders in the “Institutsrat” help to exchange of important information in a personal manner and informal environment. I thank you all for your contributions and time you dedicate to the “Institutsrat” as in my opinion the personal contact is a relevant key to a cooperative environment. And the latter is very important for the overall success of the IPA! Along these lines, I also wish to express my sincere thanks to Univ. Prof. Hannes Stockinger, the head of the centre for Pathophysiology, Infection, and Immunology (CePII), for his transparent policy and continuous support of the IPA. This support has allowed us the continuation of excellent science and academic teaching in a cooperative atmosphere and is an important basis for our future! Thank you all for your efforts, dedication and willingness to contribute to the strong team spirit and make the IPA what it is!

Barbara Bohle Head of the IPA

General overview The 18 research groups at the IPA cover various topics, such as basic and translational aspects in cellular and molecular pathophysiology, immunopathology, comparative immunology, oncology, medical biotechnology and allergology. In 2017, these efforts resulted in numerous publications in peer-reviewed high-impact journals, research awards and many contributions to prestigious scientific national and international meetings. A total sum of LOM-relevant 243 impact factors was gained in 2017. Figure 1 gives an overview on the development of the LOM-calculated impact factors of the IPA since 2012. I congratulate each member to this great achievement!

The percentage of papers accepted in top, standard and other journals in the respective fields of research is given in Figure 2 and reflects the high quality of the research performed at the IPA as the vast majority of papers are published in top journals.

Despite of more difficult conditions for funding, the IPA members continued to be successful in recruiting third party money and research grants as shown in figure 3 which gives an overview on the LOM-relevant impact factors achieved by grants since 2012. However, the declining tendency of third party funding in the past years is clearly visible.

Congratulations to all project leaders who successfully run research projects funded by the Austrian Science Fund (FWF), the Österreichische Nationalbank, the medizinisch- wissenschaftlicher Fonds des Bürgermeisters der Stadt Wien and the European Commission

or funded in cooperations with companies! As in the previous years, the total sum of third party funding makes 95% of the IPA budget and more than 60% of our staff is paid by this money. This positive funding situation also reflects that the members of the IPA are highly active researchers and well embedded in the international fields of their expertise. The IPA is proud of several successful and long lasting collaborations with national and international research partners. In addition to research, the IPA takes teaching and education very seriously. In 2017, a total of 110 Austrian and international bachelor, diploma and PhD students were educated. Figure 4 illustrates the total numbers of diploma (white circles), PhD (black circles) and bachelor students (black triangles) over the past years. Several group leaders are involved in doctoral programs funded by the FWF which also reflects the high quality of training of PhD students at the IPA. The high commitment of the IPA’s members to teaching is also reflected by the total numbers of semester hours of the members of the IPA held at the Medical University (Figure 5). Our achievements in teaching in total equal 161,62 LOM-relevant impact factors.

Regular “Impulse Seminars” have been held at the IPA in 2017 during which the different group leaders at the IPA present their latest scientific achievements. These seminars can be regarded as advanced training for IPA members but are also open for external guests. This year, it has also been decided that in the future also PostDocs at the IPA will be invited to present their scientific results in “Impulse Seminars”. Furthermore, several members of the IPA are active in teaching and examining at other universities. Many IPA members also act as reviewers of external diploma and PhD theses, Habilitations, scientific manuscripts and research grants, and are active on editorial and advisory boards and on the boards of national and international research societies. At our website www.meduniwien.ac.at/hp/ipa/ we monthly publish our research papers to make our scientific achievements visible for the public. Moreover, our “news and activities” announce awards and personal achievements of the members of the IPA.

Thank you all for your active contribution to the performance of the IPA! 5

Performance Report 2017 Organigram

Organigram (December 2017)

Head: Barbara Bohle, PhD, Professor for Cellular Allergology Deputy Head: Peter Pietschmann, MD, Professor Department Secretary: Marion Sack Check point: Andreas Kunrath Student Secretary: Marion Krones, Zorica Stanojevic

Division for Comparative Immunology and Oncology

Head: Erika Jensen-Jarolim, MD, Professor for Pathophysiology, Professor for Comparative Medicine Secretary: Nora Diallo Martina Salzmann, BMA 50% WG AllergoOncology: Head: Erika Jensen-Jarolim, MD, Professor Beatrix Pfanzagl, Ass. Professor Christina Pranger, PhD-Student Franziska Roth-Walter, PhD Stella Ahlers, Diploma Student Lukas Einhorn, PhD- Student Lena Kreutzer, Diploma Student Judit Fazekas, PhD- Student Larissa Kawasch, Diploma Student Jelena Gotovina, PhD- Student Anton Vidovic, Diploma Student Jordakieva Galateja, PhD- Student Lucie Pribylova, Diploma Student Sheriene Afifi-Moussa, PhD-Student Alina Groschopf, Diploma Student Ina Herrmann, PhD-Student Julia Sikora, Diploma Student Verena Köhler, PhD-Student

WG Tumor Pathology: Head: Enikö Kallay, PhD, Assoc. Professor Luca Iamartino, PhD-Student Rebecca Grüneis, Diploma Student Taha Elajnaf, PhD-Student Malgorzata Cichon, Diploma Student Judit Repas, Diploma Student Teresa Manhardt, CTA Nora Geissler, Diploma Student Maria Elena Manfredini, Project manager Himadri Bahadur, Diploma Student

WG Gastrointestinal Immunology: Head: Eva Untersmayr-Elsenhuber, MD, Assoc. Professor. Nazanin Samadi, PhD-Student Carmen Müllauer, Diploma Student Klara Sepova, Diploma Student Judith Pekar, Bachelor Student Eleonore Weidmann, Diploma Student Anna Blaas, Bachelor Student

WG Molecular Research in Traditional Chinese Medicine: Head: Yan Ma, PhD, Assoc. Professor Administration TCM: Ulrike Loidl He Shan, PhD-Student Xiaoxia Wang, Master Student Lene Ladanyi, Master Student Astrid Feder, Master Student Svenja Krüger, Master Student Mao Xinjun, Master Student Winnie Xiao, Master Student Zheng Prokop, Master Student Amar Saciri, Master Student

Performance Report 2017 Organigram

Division for Cellular and Molecular Pathophysiology

Head: Peter Pietschmann, MD, Assoc. Professor Secretary: Birgit Schwarz Martina Salzmann, BMA 50% WG Bone, Cartilage and conn. Tissue Research: Head: Peter Pietschmann, MD, Assoc. Professor Robert Wakolbinger, PhD-Student Marchetti Sebastian, Diploma Student Sonja Walzer, PhD-Student Carina Quack, Diploma Student Adalbert Raimann, PhD-Student Andreas Grügl, Diploma Student György Vekszler,PhD-Student Lueger Anna, Diploma Student Daniela Bieder, PhD-Student Mathias Schmidt, Diploma-Student Mahmoud Elshamly, PhD-Student Maximilina Stundner, Diploma Student Lukas Panzenböck, PhD-Student Jennifer Kellner Bachelor Student Nicolas Haffner, PhD-Student Linda Rieschl, Bachelor Student Julia Köttsdorfer, PhD-Student Katharina Wahl, CTA

WG Pathophysioloy of the Placenta: Head: Isabella Ellinger, PhD, Assoc, Professor Haleh Ganjian, PhD-Student Amirreza Mahbod, PhD-Student Jost Kemper, Diploma-Student Wolfgang Seebacher, Diploma Student Christoph Jungwirth, Diploma Student Katharina Gelles, BMA

WG Molecular System Biology and Pathophysiology Head: Diana Mechtcheriakova, PhD, Assoc. Professor Anastasia Meshcheryakova, PhD-Student Andrea Oswald, Diploma Student Mungenast Felicitas, PhD-Student

Division for Immunopathology

Head: Rudolf Valenta, MD, Professor for Allergology Secretary: Doris Werjant SFB-Secretary: Anna Guentcheva Milena Weber, CTA WG Molecular Immunopathology: Head: Rudolf Valenta, MD, Professor Christian Lupinek, MD Kristina Borochova, PhD-Student Raffaela Campana, PhD Carolin Cornelius, PhD-Student Katarzyna Niespodziana, PhD Sheron Dzoro, PhD-Student Kuan Wei-Chen, PhD Pia Gattinger, PhD-Student Mirela Curin, PhD Eszter Sarzsinszky, Master Student Inna Tulaeva PhD-Student Renata Kiss, CTA

WG Immunotechnology: Head: Susanne Vrtala, PhD, Assoc. Professor Yvonne Resch, PhD Huey-Jy Huang, PhD-Student Azahara Rodríguez-Domínguez, PhD-Student

WG Immunochemistry: Head: Margarete Focke-Tejkl, PhD, Assoc. Professor Yulia Dorofeeva, PhD-Student Mary Kodydek, PhD-Student

WG Antibody Research Head: Sabine Flicker, PhD, Assoc. Professor Nazanin Najafi, PhD-Student Daniel Ivanov Master Student

Performance Report 2017 Organigram

WG Pathomechanisms of Allergy Head: Birgit Linhart, PhD, Assoc. Professor Raphaela Freidl, PhD-Student

WG Molecular Allergen Characterization Head: Irene Mittermann, PhD, PD Dr.

Division for Medical Biotechnology

Head: Heimo Breiteneder, PhD, Professor for Medical Biotechnology Secretary: Petra Natascha Hendler Vanessa Mayr, BMA WG Biotechnology & Biochemical Diagnostics: Head: Heimo Breiteneder, PhD, Professor Merima Bublin, PhD Chiara Palladino, PhD-Student Christine Hafner, MD Tanja Kalic, PhD-Student Angelika Tscheppe, PhD-Student Karolina Uranowska, PhD-Student Öykü Üzülmez, PhD-Student Zarina Iskakova, Master Student

WG Molecular Allergology: Head: Karin Hoffmann-Sommergruber, PhD, Assoc. Professor Piotr Humeniuk, PhD-Student Stefan Kabasser, Master Student Pawel Dubiela, PhD-Student Christph Nagl, BMA Günther Grasserbauer, Master Student

WG Biochemistry and Bioinformatics: Head: Christian Radauer, PhD, Assoc. Professor Jaana Schneider, Bachelor Student

Division for Experimental Allergology

Head: Barbara Bohle, PhD, Professor for Cellular Allergology Secretary: Dorothea Angelides Ute Vollmann, BMA WG Allergy Research: Head: Barbara Bohle, PhD Claudia Kitzmüller, PhD Dominika Polak, PhD-Student Caterina Vizzardelli, PhD Joao Rodrigues Grilo, PhD-Student Gabriela Sanchez-Acosta, PhD-Student Maria Regina Strobl, PhD-Student

WG Cellular Allergology: Head: Beatrice Jahn-Schmid, PhD Assoc. Professor Manuel Reithofer, PhD-Student Jasmine Karacs, PhD-Student

Facility Services and Animal Keeping:

Katharina Reinberger Brigitte Schwarz Andrea Vlasaty

Performance Report 2017 Personnel

a) Personnel of IPA (between January and December 2017)1

Personnel (p.) 01.01.2017 31.12.2017 MUW total female total female Univ.Prof. (full professors) RV, EJJ, BB, HB 4.00 2.00 RV, EJJ, BB, HB, 5.00 2.00 PP Ao.Univ.Prof (Assoc.Prof) IE, RF, PP, CR 4.00 2.00 IE, CR 2.00 1.00 Univ./Priv.Doz. (Assoc.Prof) EUE,BJS,MFT,DM, 9.00 9.00 EUE,BJS,MFT,DM, 9.00 9.00 KHS,EK,SV,YM, KHS,EK,SV,YM, BL BL Assistant professors BP, MB 2.00 2.00 BP, MB 2.00 2.00 Technical personnel VM,KG,TM,MM,CN 9.00 8.00 VM,KG,TM,MM,CN, 9.00 8.00 ,KW,BN,MW, MS KW,BN,MW, MS

Administrative personnel MS, AK, ZK, PNH, 9.00 8.00 MS, AK, ZK, PNH, 9.00 8.00 DW, DA, BS, MK, DW, DA, BS, MK, ZS ZS Supportive personnel AV, KR, BS 3.00 3.00 AV, KR, BS 3.00 3.00 40.00 34.00 39.00 33.00 Third party funded p. Scientific personnel Univ.Doz. 3.00 3.00 3.00 3.00 (Assoc.Prof) SF, IM, IPS PostDoc 16.00 14.00 14.00 12.00 Doctoral students2 43.00 37.00 45.00 38.00 Technical personnel BMA 1.00 1.00 1.00 1.00 CTA 1.00 1.00 1.00 1.00 Administrative personnel CU, AG 2.00 2.00 CU, AG 2.00 2.00 Project employees UFS , UL 2.00 2.00 UFS , UL 2.00 2.00 Diploma students (FB3) 8.00 6.00 10.00 8.00 76.00 66.00 75.00 64.00

Other scientific Doctoral students 5.00 4.00 8.00 6.00 coworkers Diploma students 26.00 19.00 25.00 19.00 Student 3.00 1.00 3.00 1.00 apprentices 34.00 24.00 36.00 26.00 MUW personnel total 150.00 124.00 150.00 123.00

At the end of 2017 26% of the entire personnel was MUV-paid personnel. Of all IPA-employees 82% were female.

1 in full time equivalents “FTE” 40 h = 1 FTE 2 due to novel rules by FWF PhD students are employed 75 % FTE to be able to spend time for education 3 FB: Forschungsbeihilfe: defined financial support 10

Performance Report 2017 Impulsseminare

Continuous education of staff

Among the activities in the field of continuous education of the members of the Department in 2017 six “impulse seminars” were held. In these seminars, research group leaders present and discuss recent results from their projects. The seminars were very well attended and significantly promoted communication and active discussion among the members of the IPA. The “impulse seminars” are recognized as continuous medical education by the Austrian Chamber of Physicians. In 2017 the following topics were covered:

13.01.2017 Christian Radauer The AllFam database of allergen families: history, applications and future development. 07.04.2017 Barbara Bohle An apple a day keeps the doctor away! 05.05.2017 Heimo Breiteneder Peanut allergy - the Austrian contribution. 09.06.2017 Isabella Ellinger Characterization of iron transport in the human placenta. 13.10.2017 Susanne Vrtala Allergen microarrays for diagnosis of house dust mite allergy. 17.11.2017 Sabine Flicker Allergen-specific antibodies- from basic findings towards feasible applications.

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

1. Detailed Reports of Divisions

1.1. Division for Comparative Immunology and Oncology Head: Erika Jensen-Jarolim, MD, Professor

1. Publications4 IF Number Top/Std/Subst Erika Jensen-Jarolim 55.742 15 11 Top, 1 St, 3 Sub Enikö Kallay 13.602 5 5 Top Yan Ma 0 0 - Eva Untersmayr- Elsenhuber 2.687 3 2 Top, 1 Sub Division-Sum 72.031 23 Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2

2. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Erika Jensen-Jarolim 2 10 10 Enikö Kallay - 5 2 Yan Ma - 4 5 Eva Untersmayr- Elsenhuber 6 4 - Sum 8 23 17

3. Teaching SS* WS* total W+S oral Exams Erika Jensen-Jarolim 9.42 5.97 15.39 10 Enikö Kallay 2.73 6.97 9.70 - Yan Ma 4.25 2.50 6.75 - Eva Untersmayr- Elsenhuber 4.66 6 10.66 1 Sum 21.06 21.44 42.50 11

4 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications. 13

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

1.1.1. Publications a) Peer-reviewed original articles: n = 25

Nr. Article IF Class pro-rata IF 1. Ilieva KM, Fazekas-Singer J, Achkova DY, Dodev TS, Mele 6.429 Top 1.286 S, Crescioli S, Bax HJ, Cheung A, Karagiannis P, Correa I, Figini M, Marlow R, Josephs DH, Beavil AJ, Maher J, Spicer JF, Jensen-Jarolim E, Tutt AN, Karagiannis SN. Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields; Front Immunol. 2017 Sep 11;8:1112. doi: 10.3389/fimmu.2017.01112. eCollection 2017.

2. Jordakieva G, Kundi M, Lemell P, Zieglmayer R, Zieglmayer 4.259 Top 4.259 P, Godnic-Cvar J, Jensen-Jarolim E. Sublingual house dust mite immunotherapy has no impact on decrease of circulating erythrocytes upon airway allergen challenge in allergic rhinitis; Sci Rep. 2017 May 31;7(1):2555. doi: 10.1038/s41598-017- 02321-y. PMID: 28566688

3. Pfanzagl B, Mechtcheriakova D, Meshcheryakova A, Aberle 4.259 Top 4.259 SW, Pfragner R, Jensen-Jarolim E. Activation of the ileal neuroendocrine tumor cell line P-STS by acetylcholine is amplified by histamine: role of H3R and H4R; Sci Rep. 2017 May 2;7(1):1313. doi: 10.1038/s41598-017-01453-5. PMID: 2846556

4. Fazekas J, Grunt TW, Jensen-Jarolim E, Singer J. Long 5.168 Top 5.168 term storage in liquid nitrogen leads to only minor phenotypic and gene expression changes in the mammary carcinoma model cell line BT474; Oncotarget. 2017 May 23;8(21):35076- 35087. doi: 10.18632/oncotarget.16623. PMID: 28402269

5. Jensen-Jarolim E, Pali-Schöll I, Roth-Walter F. 3.463 Top 3.463 Outstanding animal studies in allergy II. From atopic barrier and microbiome to allergen-specific immunotherapy; Curr Opin Allergy Clin Immunol. 2017 Jun;17(3):180-187. doi: 10.1097/ACI.0000000000000364. PMID: 28375932

6. Jensen-Jarolim E, Pali-Schöll I, Roth-Walter F. 3.463 Top 3.463 Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis; Curr Opin Allergy Clin Immunol. 2017Jun;17(3):169-179.doi: 10.1097/ACI.0000000000000363. PMID: 28346234

7. Roth-Walter F, Bergmayr C, Meitz S, Buchleitner S, 4.259 Top 4.259 Stremnitzer C, Fazekas J, Moskovskich A, Müller MA, Roth GA, Manzano-Szalai K, Dvorak Z, Neunkirchner A, Jensen- Jarolim E. Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure; Sci Rep. 2017 Mar 23;7:45067. doi: 10.1038/srep45067. PMID: 28332605

8. Roth-Walter F, Bianchini R, Jensen-Jarolim E. Linking iron- 3.975 Std 3.975

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

deficiency with Allergy: role of molecular allergens and the microbiome; Metallomics 2017, accepted

9. Jensen-Jarolim E, Bax HJ, Bianchini R, Crescioli S, 7.361 Top 7.361 Daniels-Wells TR, Dombrowicz D, Fiebiger E, Gould HJ, Irshad S, Janda J, Josephs DH, Levi-Schaffer F, O Mahony L, Pellizzari G, Penichet ML, Redegeld F, Roth-Walter F, Singer J, Untersmayr E, Vangelista L, Karagiannis SN. AllergoOncology: Opposite outcomes of immune tolerance in allergy and cancer; Allergy. 2017 Sep 16. doi: 10.1111/all.13311

10. Lebherz-Eichinger D, Tudor B, Ankersmit HJ, Reiter T, Haas 2.806 Top 0.561 M, Einwallner E, Roth-Walter F, Krenn CG, Roth GA. Increased trefoil factor 2 levels in patients with chronic kidney disease; PLoS One. 2017 Mar 29;12(3):e0174551

11. Fazekas-Singer J, Berroterán-Infante N, Rami-Mark C, 5.168 Top 5.168 Dumanic M, Matz M, Willmann M, Andreae F, Singer J, Wadsak W, Mitterhauser M, Jensen-Jarolim E. Development of a radiolabeled caninized anti-EGFR antibody for comparative oncology trials; Oncotarget. 2017; 8:83128- 83141. doi: 10.18632/oncotarget.20914

12. Oida K, Einhorn L, Herrmann I, Panakova L, Resch Y, Vrtala S, Hofstetter G, Tanaka A, Matsuda H, Jensen-Jarolim E. Innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated pH; World Allergy Organ J. 2017 Jul 4;10(1):23. doi: 10.1186/s40413- 017-0154-3. eCollection 2017. PMID: 28702111

13. Pali-Schöll I. Adverse reactions to food: the female 0.311 Subst 0.311 dominance; Allergologie, Jahrgang 40, Nr. 3/2017, S. 101-110

14. Herrmann I, Panakova L. Genderaspects in allergies in our 0.311 Subst 0.311 pet animals; Allergologie, Jahrgang 40, Nr. 3/2017, S. 128- 132

15. Pali-Schöll I, Namazy J, Jensen-Jarolim E. Allergic diseases and asthma in pregnancy, a secondary publication; World Allergy Organ J. 2017 Mar 2;10(1):10. doi: 10.1186/s40413-017-0141-8. eCollection 2017. Review. PMID: 28286601

16. Koper I, Hufnagl K, Ehmann R. Gender aspects and influence of hormones on bronchial asthma; Secondary publication and update. World Allergy Organization Journal

17. Afify MS, Pali-Schöll I. Adverse reactions to food: the female dominance. A secondary publication and Update; World Allergy Organization Journal.

18. Raulf M, Brüning T, Jensen-Jarolim E, van Kampen V. Occupational allergies: role of gender aspects. Secondary publication and Update; World Allergy Organization Journal.

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

19. Herrmann I, Einhorn L, Panakova L. Gender aspects in allergies of our pets. A secondary publication and Update; World Allergy Organization Journal.

20. Babinsky VN, Hannan FM, Ramracheya RD, Zhang Q, Nesbit 4.286 Top 0.867 MA, Hugill A, Bentley L, Hough TA, Joynson E, Stewart M, Aggarwal A, Prinz-Wohlgenannt M, Gorvin CM, Kallay E, Wells S, Cox RD, Richards D, Rorsman P, Thakker RV. Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy; Endocrinology. 2017 Aug 1;158(8):2486-2502. doi: 10.1210/en.2017-00111.

21. Aggarwal A, Schulz H, Manhardt T, Bilban M, Thakker RV, 4.521 Top 4.521 Kallay E. Expression profiling of colorectal cancer cells reveals inhibition of DNA replication licensing by extracellular calcium; Biochim Biophys Acta. 2017 Jun; 1864(6):987-996. doi: 10.1016/j.bbamcr.2017.01.017.

22. Luger M, Kruschitz R, Kienbacher C, Traussnigg S, Langer 3.947 Top 0.789 FB, Prager G, Schindler K, Kallay E, Hoppichler F, Trauner M, Krebs M, Marculescu R, Ludvik B. Vitamin D3 Loading Is Superior to Conventional Supplementation After Weight Loss Surgery in Vitamin D-Deficient Morbidly Obese Patients: a Double-Blind Randomized Placebo-Controlled Trial; Obes Surg. 2017 May;27(5):1196-1207. doi: 10.1007/s11695-016- 2437-0.

23. Hegedũs L, Garay T, Molnár E, Varga K, Bilecz Á, Török S, 6.513 Top 6.513 Padányi R, Pászty K, Wolf M, Grusch M, Kállay E, Döme B, Berger W, Hegedũs B, Enyedi A. The plasma membrane Ca2+ pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells; Int J Cancer. 2017 Jun 15;140(12):2758-2770. doi: 10.1002/ijc.30503. Epub 2016 Nov 17.

24. Rieder FJ, Gröschel C, Kastner MT, Kosulin K, Laengle J, 4.561 Top 0.912 Zadnikar R, Marculescu R, Schneider M, Lion T, Bergmann M, Kallay E, Steininger C. Human cytomegalovirus infection downregulates vitamin-D receptor in mammalian cells; J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):356-362. doi: 10.1016/j.jsbmb.2016.08.002.

25. Camps-Bossacoma M, Pérez-Cano FJ, Franch À, 4.518 Top 0.904 Untersmayr E, Castell M. Effect of a cocoa diet on the small intestine and gut-associated lymphoid tissue composition in an oral sensitization model in rats; J Nutr Biochem. 2017 Apr;42:182-193. doi: 10.1016/j.jnutbio.2017.01.005. sum 78.956 53.696

Performance Report 2017 – Division 1 Comparative Immunology and Oncology b) Invited Articles & Reviews with IF: n = 3

Nr. Article IF Class pro-rata IF 1. Jensen-Jarolim E. Gender Effekte in der Allergologie, ein 0.311 Subst 0.311 Update; Allergologie 2017, 40 (3), 91-93 2. Jensen-Jarolim E, Turner MC, Karagiannis SN. 13.081 Top 13.081 AllergoOncology: IgE- and IgG4-mediated immune mechanisms linking allergy with cancer and their translational implications; J Allergy Clin Immunol. 2017 May 17. pii: S0091- 6749(17)30758-3. doi: 10.1016/j.jaci.2017.04.034. No abstract available. PMID: 28526623

3. Untersmayr E. Allergie gegen Hormone: Klinik, Ursachen 0.311 Subst 0.311 und mögliche Behandlungsstrategien; Allergologie 2017, 40 (3), 111-116 sum 13.392 13.392

c) Invited Articles & Reviews without IF: n = 4

Erika Jensen-Jarolim 1. Jensen-Jarolim E, Fiocchi A. World Allergy Organization Journal: the Editors Look Back at 2016; World Allergy Organ J. 2017 Jan 23;10(1):9. doi: 10.1186/s40413-017-0140-9. eCollection 2017. No abstract available. PMID: 28138353 2. Kowalski ML, Ansotegui I, Aberer W, Al-Ahmad M, Akdis M, Ballmer-Weber BK, Beyer K, Blanca M, Brown S, Bunnag C, Hulett AC, Castells M, Chng HH, De Blay F, Ebisawa M, Fineman S, Golden DB, Haahtela T, Kaliner M, Katelaris C, Lee BW, Makowska J, Muller U, Mullol J, Oppenheimer J, Park HS, Parkerson J, Passalacqua G, Pawankar R, Renz H, Rueff F, Sanchez-Borges M, Sastre J, Scadding G, Sicherer S, Tantilipikorn P, Tracy J, van Kampen V, Bohle B, Canonica GW, Caraballo L, Gomez M, Ito K, Jensen- Jarolim E, Larche M, Melioli G, Poulsen LK, Valenta R, Zuberbier T. Erratum to: Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement; World Allergy Organ J. 2017 Jan 11;10(1):6. doi: 10.1186/s40413-016-0134-z. eCollection 2017. PMID: 28101294

Enikö Kallay 1. Hegedüs L, Padányi R, Molnár J, Pászty K, Varga K, Kenessey I, Sárközy E, Wolf M, Grusch M, Hegyi Z, Homolya L, Aigner C, Garay T, Hegedüs B, Tímár J, Kállay E, Enyedi Á. Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca2+ Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK. Front Oncol. 2017 May 24;7:95. doi: 10.3389/fonc.2017.00095. eCollection 2017

Eva Untersmayr-Elsenhuber 1. Untersmayr E, Jensen AN, Walch K. Sex hormone allergy: clinical aspects, causes and therapeutic strategies - Update and secondary publication. World Allergy Organ J. 2017 Dec 27;10(1):45. doi: 10.1186/s40413-017-0176-x.

Performance Report 2017 – Division 1 Comparative Immunology and Oncology d) Book contributions: n =7

Erika Jensen-Jarolim 1. Roth-Walter F, Berger, S Luckschander-Zeller N. Inflammatory Bowel Disease in Humans, Pets, and Horses (chapter 4). In: Jensen-Jarolim (Ed) Comparative Medicine – Disorders linking Humans with their Animals. Springer. ISBN 978-3-319-47005-4 (Print) ISBN 978-3-319-47007-8 (Online), p47-70. 2. Hufnagl K, Hirt R, Robibaro B. Out of Breath: Asthma in Humans and Their Animals. (chapter 5). In: Jensen-Jarolim (Ed) Comparative Medicine – Disorders linking Humans with their Animals. Springer. ISBN 978-3-319-47005-4 (Print) ISBN 978-3-319-47007- 8 (Online), p71-86. 3. Glenk LM, Kothgassner OD. Life Out of Balance: Stress-Related Disorders in Animals and Humans. (chapter 7). In: Jensen-Jarolim (Ed) Comparative Medicine – Disorders linking Humans with their Animals. Springer. ISBN 978-3-319-47005-4 (Print) ISBN 978- 3-319-47007-8 (Online), p97-108. 4. Pali-Schöll I, Herrmann I, Jensen-Jarolim E, Iben C. Allergies, with Focus on Food Allergies, in Humans and Their Animals. (chapter 8). In: Jensen-Jarolim (Ed) Comparative Medicine – Disorders linking Humans with their Animals. Springer. ISBN 978-3-319-47005-4 (Print) ISBN 978-3-319-47007-8 (Online), p109-130. 5. Jensen-Jarolim E, Herrmann I, Panakova L, Janda J. Allergic and Atopic Eczema in Humans and Their Animals. (chapter 8). In: Jensen-Jarolim (Ed) Comparative Medicine – Disorders linking Humans with their Animals. Springer. ISBN 978-3-319-47005-4 (Print) ISBN 978-3-319-47007-8 (Online), p131-150.

Yan Ma 1. Yan Ma, Shan He, Ulrike Loidl. Was sind Chinesische Medizin und Chinesische Kultur? Kinderuni Wien 2017. Studienbuch S96. Vienna General Hospital, Medical University of Vienna, July 18th-22nd 2017

Eva Untersmayr-Elsenhuber 1. Untersmayr E. The Gut Microbiome and its marriage to the immune system: Can we change it all?. In: Allgery Prevention and Exacerbation. Verlag: Springer. Editor: Carsten B. Schmidt-Weber

e) Abstracts, printed in periodicals: n = 12

Erika Jensen-Jarolim 1. Hufnagl K, Ghosh D, Wagner S, Fiocchi A, Roth-Walter F, Roth G, Hofstetter G, Pacios L, Jensen-Jarolim E. Binding of the active vitamin A metabolite retinoic acid impairs immunogenicity of the major cows' milk allergen Bos D 5, Allergy 72, 812-812 (2017). 2. Pali-Schöll I, Roth-Walter F, Hofstetter G, Hann S, Ahlers S, Moussa Afify S, Wittek T, Vercelli D, Von Mutius E, Jensen-Jarolim E. The lipocalin beta-lactoglobulin accumulates in stable dust: potential implications for the allergy- and asthma-protective effect, Allergy 72, 556-556 (2017). 3. Roth-Walter F, Moussa Afify S, Vidovic A, Pali-Schöll I, Pacios LF, Hann S, Jensen- Jarolim E. What makes an allergen an allergen? the sensitization capacity to the paradigmatic lipocalin allergen bos d 5 critically depends on its ligand loading state in BALB/c mice, Allergy 72, 472-473 (2017).

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

4. Jordakieva G, Kundi M, Lemell P, Zieglmayer R, Zieglmayer P, Godnic-Cvar J, Jensen- Jarolim E. Circulating erythrocytes decrease and neutrophils increase upon airway allergen challenge in house dust mite allergic rhinitis subjects independent of sublingual immunotherapy, Allergy 72, 476-477 (2017). 5. Fazekas J, Singer J, Ilieva K, Matz M, Hermann I, Karagiannis SN, Jensen-Jarolim E. AllergoOncology: the canine IgE antibody 'can225IgE-?' triggers strong and specific effector-cell mediated cytotoxicity against EGFR plus tumor cells, Allergy 72, 446-447 (2017). 6. Mothes-Luksch N, et al. High fidelity of an allergen microarray for first line screening of type i allergy: results from a clinical study, Allergy 72, 431-432 (2017). 7. Pranger CL, Gotovina J, Jensen AN, Wagner S, Kothgassner O, Larenas Linnemann D, Singh J, Mösges R, Mothes-Luksch N, Glenk LM, Jensen-Jarolim. Effects of acute stress on the reliability of skin prick testing and mediator release: clinical study in healthy and allergic volunteers using the Trier social stress test, Allergy 72, 434-434 (2017). 8. Roth-Walter F, Schmutz R, Mothes-Luksch N, Zieglmayreer P, Zieglmayer R, Jensen- Jarolim E. Increased lcn2-levels after sublingual immunotherapy against house dust mites is associated with amelioration of symptoms. Allergy 72, 274-275 (2017). 9. Gotovina J, Bianchini R, Roth-Walter F, Haidl ID, Marshall JS, Jensen-Jarolim E. Can acute stress dampen allergic reactions? Epinephrine induces a regulatory M2b-like macrophage phenotype, which attenuates cord blood-derived mast cell (CBMC) IgE- mediated degranulation, Allergy 72, 193-193 (2017). 10. Bianchini R, Roth-Walter F, Flicker S, Ohradanova-Repic A, Roth G4, Fischer MB, Stockinger H, Hufnagl K, Jensen-Jarolim E. IgG4, but not IgG1, repolarizes pro-allergic M2a macrophages to a tolerogenic M2b-like phenotype: implications for allergen immunotherapy-mediated immune tolerance, Allergy 72, 40-41 (2017).

Eva Untersmayr-Elsenhuber 1. Halibasic E, Fuerst E, Heiden D, Japtok L, Diesner SC, Hillebrand P, Trauner M, Kleuser B, Kazemi-Shirazi L, Untersmayr E. Significantly reduced plasma levels of the bioactive sphingolipid S1P in lung transplanted cystic fibrosis patients are associated with gastrointestinal symptoms, Allergy 72, 195 (2017). 2. Aliakhnovich N, Heiden D, Klems M, Novikov D, Untersmayr E. Effects of titanium dioxide nanoparticles on food allergy development, Allergy 72, 480 (2017).

f) Abstracts, in congress proceedings or abstract books: n = 49

Erika Jensen-Jarolim 1. Jordakieva G, Mothes-Luksch N, Hinterhölzl E, Jensen AN, Hallmann PK, Kundi M, Jensen-Jarolim E, Klinische Studie zur Reliabilität von IgE-Microarray versus Haut-Prick- Test als First-Line-Screening-Diagnostik bei allergischen Sensibilisierungen, 57. Wissenschaftliche Jahrestagung der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin 2017 (DGAUM 2017), Hamburg, Germany, March 16, 2017 2. Jordakieva G, Kundi M, Lemell P, Zieglmayer R, Zieglmayer P, Godnic-Cvar J, Jensen- Jarolim E. Circulating erythrocytes decrease and neutrophils increase upon airway allergen challenge in house dust mite allergic rhinitis subjects independent of sublingual immunotherapy, European Academy of Allergy and Clinical Immunology (EAACI) 2017, Helsinki, Finland, June 17 – 21, 2017 3. Bianchini R, Roth-Walter F, Flicker S, Ohradanova-Repic A, Roth G,. Fischer MB, Valenta R, Stockinger H, Hufnagl K, Jensen-Jarolim E. IgG4, but not IgG1, repolarizes

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

pro-allergic M2a macrophages to a tolerogenic M2b-like phenotype: Implications for allergen immunotherapy-mediated immune tolerance, European Academy of Allergy and Clinical Immunology (EAACI) 2017, Helsinki, Finland, June 17 – 21, 2017 4. Fazekas J, Singer J, Ilieva K, Matz M, Hermann I, Karagiannis SN, Jensen-Jarolim E. AllergoOncology: The canine IgE antibody ‘can225IgE-λ’ triggers strong and specific effector-cell mediated cytotoxicity against EGFR+ tumor cells, European Academy of Allergy and Clinical Immunology (EAACI) 2017, Helsinki, Finland, June 17 – 21, 2017 5. Gotovina J, Bianchini R, Roth-Walter F, Heidl ID, Marshall JS, Jensen-Jarolim E. Can acute stress dampen allergic reactions? Epinephrine induces a regulatory M2b-like macrophage phenotype, which attenuates cord blood-derived mast cells (CBMCs) degranulation in a human model of allergic inflammation, European Academy of Allergy and Clinical Immunology (EAACI) 2017, Helsinki, Finland, June 17 – 21, 2017 6. Hufnagl K, Ghosh D, Wagner S, Fiocchi A, Roth-Walter F, Roth GA, Hofstetter G, Pacios LF, Jensen-Jarolim E. Binding of the active vitamin A metabolite retinoic acid impairs immunogenicity of the major cows milk allergen Bos d 5, European Academy of Allergy and Clinical Immunology (EAACI) 2017, Helsinki, Finland, June 17 – 21, 2017 7. Mothes-Luksch N, Jordakieva G, Hinterhölzl L, Jensen AN, Hallmann PK, Kundi M, Jensen-Jarolim E. High fidelity of ISAC112 microarray for first line screening of type I allergy: results from a clinical study, European Academy of Allergy and Clinical Immunology (EAACI) 2017, Helsinki, Finland, June 17 – 21, 2017 8. Pali-Schöll I, Roth-Walter F, Hofstetter G, Hann S, Ahlers S, Moussa Afify S, Wittek T, Vercelli D, von Mutius E, Jensen-Jarolim Erika. The lipocalin beta-lactoglobulin (BLG) accumulates in stable dust: potential implications for the allergy- and asthma-protective effect, European Academy of Allergy and Clinical Immunology (EAACI) 2017, Helsinki, Finland, June 17 – 21, 2017 9. Pranger CL, Gotovina J, Jensen AN, Wagner S, Kothgassner OD, Larenas-Linnemann D, Singh J, Mösges R, Mothes-Luksch N, Glenk LM, Jensen-Jarolim E. Effects of acute stress on the reliability of skin prick testing and mediator release: Clinical study in healthy and allergic volunteers using the Trier social stress test, European Academy of Allergy and Clinical Immunology (EAACI) 2017, Helsinki, Finland, June 17 – 21, 2017 10. Roth-Walter F, Afify S, Vidovic A, Pacios LF, S Hann S, Pali-Schöll I, Jensen-Jarolim E. Sensitization to lipocalin allergens depends on the loading state: the apo-, but not the holo-form caused symptomatic allergy in a BALB/c mouse model, European Academy of Allergy and Clinical Immunology (EAACI) 2017, Helsinki, Finland, June 17 – 21, 2017 11. Roth-Walter F, Schmutz R, Mothes-Luksch N, Zieglmayer P, Zieglmayer R, Jensen- Jarolim Erika. Lipocalin-2 (LCN2) is a potential biomarker for clinical success of sublingual allergen immunotherapy to house dust mites, European Academy of Allergy and Clinical Immunology (EAACI) 2017, Helsinki, Finland, June 17 – 21, 2017 12. Jordakieva G. Circulating erythrocytes decrease and neutrophils increase upon airway allergen challenge in house dust mite allergic rhinitis subjects independent of sublingual immunotherapy, European Academy of Allergy and Clinical Immunology (EAACI) 2017, Helsinki, Finland, June 17 – 21, 2017 13. Purschke B, Scheibelberger R, Axmann S, Adler A, Pali-Schöll I, Meinlschmidt P, Hofstetter G, Einhorn L, Mothes-Luksch N, Jensen-Jarolim E, Jäger H. Safety aspects of edible insects for use in the food and feed value chain - investigations of bioaccumulation of contaminants and process-induced mitigation of allergenicity, INSECTA Conference 2017, Berlin, Germany, September 7-8, 2017 14. Roth-Walter F, Moussa Afify S, Pali-Schöll I, Vidovic A, Pacios LF, Hann S, Jensen- Jarolim E. Lipocalin Bos d 5 loaded with siderophore-iron can prevent sensitization in a BALB/C model, 8th Retreat of the Center for Pathophysiology, Infectiology and

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

Immunology (CEPII), Medical University of Vienna, Dental Clinic, Vienna, Austria, September 19, 2017 15. Bianchini R, Roth-Walter F, S Flicker S, Ohradanova-Repic A, Roth G, Fischer MB, Stockinger H, Jensen-Jarolim E.. lgG4 drives macrophages to a regulatory phenotype: shedding new light on allergen immunotherapy-mediated immune tolerance, 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology (CEPII), Medical University of Vienna, Dental Clinic, Vienna, Austria, September 19, 2017 16. Braun N, Hufnagl K, Wagner S, Pacios LF, Wiederstein M, Wallner M, Hofstetter G, Roth-Walter F, Jensen-Jarolim E. Birch pollen allergen BET V 1A: reduced allergenic potential with retinoic acid in the pocket, 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology (CEPII), Medical University of Vienna, Dental Clinic, Vienna, Austria, September 19, 2017 17. Groschopf A, Bianchini R, Jordakieva G, Piehslinger J, Reichhold D, Jensen SAF, Klaus A, Jensen-Jarolim E. lgG4 drives macrophages to a regulatory phenotype: shedding also new light on tumor tolerance, 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology (CEPII), Medical University of Vienna, Dental Clinic, Vienna, Austria, September 19, 2017 18. Karin Hufnagl, Debajyoti Ghosh, Stefanie Wagner, Alessandro Fiocchi, Franziska Roth- Walter, Georg A. Roth, Gerlinde Hofstetter, Luis F. Pacios, Erika Jensen-Jarolim. Retinoic acid binds to immunodominat T-Cell epitope of cows milk allergen Bos d 5 and impairs immunogenicity, 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology (CEPII), Medical University of Vienna, Dental Clinic, Vienna, Austria, September 19, 2017 19. Pali-Schöll I, Roth-Walter F, Hofstetter G, Hann S, Ahlers S, Moussa Afify S, Wittek T, Vercelli D, von Mutius E, Jensen-Jarolim E. Immunochemical identification of the secretory cows’ protein beta-lactoglobulin (BLG) in stable dust. Implications for its allergy- and asthma-protective effect?, 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology (CEPII), Medical University of Vienna, Dental Clinic, Vienna, Austria, September 19, 2017 20. Pfanzagl B, Jensen-Jarolim E. Histamine and butyrate synergistically enhance activation of the p-sts neuroendocrine midgut carcinoid cell line by acetylcholine, 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology (CEPII), Medical University of Vienna, Dental Clinic, Vienna, Austria, September 19, 2017 21. Pranger CL, Gotovina J, Jensen AN, Wagner S, Kothgassner OD, Palme R, Mothes- Luksch N, Glenk LM, Jensen-Jarolim E. Immediate type reactivity before and after the trier social stress test: clinical study in health and allergic participants, 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology (CEPII), Medical University of Vienna, Dental Clinic, Vienna, Austria, September 19, 2017 22. Roth-Walter F, Schmutz R, Mothes-Luksch N, Zieglmayer P, Zieglmayer R, Jensen- Jarolim E. Elevated LCN2 after sublingual immunotherapy against house dust mites is associated with amelioration of symptoms, 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology (CEPII), Medical University of Vienna, Dental Clinic, Vienna, Austria, September 19, 2017 23. Ghandizadeh S, Mothes-Luksch N, Jensen AN, Kundi M, Jensen-Jarolim E. Analysis of molecular features of allergens and their relationship with clinical history by clustering and multivariate statistical methods, 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology (CEPII), Medical University of Vienna, Dental Clinic, Vienna, Austria, September 19, 2017

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

24. Pranger CL, Gotovina J, Jensen AN, Wagner S, Kothgassner OD, Palme R, Mothes- Luksch N, Glenk LM, Jensen-Jarolim E. Influence of acute stress on skin prick testing and mediator release, Molecular, Cellular and Clinical Allergology (MCCA) Symposium 2017, Vienna, Austria, September 25-27,2017 25. Einhorn L, Oida K, Herrmann I, Hofstetter G, Vrtala S, Resch Y, Panakova L, Tanaka A, Matsuda H, Jensen-Jarolim E. House dust mite enzymes synergize with mast cells to disrupt the skin barrier, Molecular, Cellular and Clinical Allergology (MCCA) Symposium 2017, Vienna, Austria, September 25-27,2017 26. Bianchini R, Roth-Walter F, Flicker S, Ohradanova-Repic A, Roth G, Fischer MB, Stockinger H, Jensen-Jarolim E. Shedding new light on allergen immunotherapy- mediated immune tolerance: IgG4 drives macrophages to a regulatory phenotype, Austrian Society for Allergology and Immunology (OEGAI) Meeting 2017, Vienna, Austria, November 23-25, 2017 27. Bianchini R, Jordakieva G, Groschopf A, Piehslinger J, Reichhold D, Jensen SAF, Klaus A, Jensen-Jarolim E. Shedding new light on tumour tolerance: IgG4 drives macrophages to a regulatory phenotype, Austrian Society for Allergology and Immunology (OEGAI) Meeting 2017, Vienna, Austria, November 23-25, 2017 28. Fazekas-Singer J, Singer J, Ilieva K, Matz M, Herrmann I, Spillner E, Karagiannis SN, Jensen-Jarolim E. Can225IgE-λ, a canine anti-EGFR IgE, triggers specific tumor killing by monocytes and mast cells, Austrian Society for Allergology and Immunology (OEGAI) Meeting 2017, Vienna, Austria, November 23-25, 2017 29. Czernohaus M, Dvorak Z, Afify SM, Kienast K, Jensen-Jarolim E, Roth-Walter F. Catechin and epicatechin are potent siderophores capable of modulating the labile iron pool and the activation status of T- and B-cells by acting via the aryl hydrogen carbon receptor, Austrian Society for Allergology and Immunology (OEGAI) Meeting 2017, Vienna, Austria, November 23-25, 2017 30. Fazekas J, Köhler V, Ilieva KM, Karagiannis SN, Jensen-Jarolim E. Generation of human IgG1 and IgE antibodies to the major birch pollen allergen Bet v 1 using PIPE cloning, Austrian Society for Allergology and Immunology (OEGAI) Meeting 2017, Vienna, Austria, November 23-25, 2017 31. Roth-Walter F, Schmutz R, Mothes-Luksch N, Zieglmayer P, Zieglmayer R, Jensen- Jarolim E. The clinical benefit after sublingual immunotherapy against house dust mites is associated with an increase of lipocalin 2, Austrian Society for Allergology and Immunology (OEGAI) Meeting 2017, Vienna, Austria, November 23-25, 2017 32. Gotovina J, Bianchini R, Roth-Walter F, Haidl ID, Marshall JS, Jensen-Jarolim E. Can acute stress dampen allergic reactions? Epinephrine shifts human monocyte-derived macrophages (MDMs) toward the regulatory M2b phenotype which attenuated IgE- mediated mast cell degranulation, Austrian Society for Allergology and Immunology (OEGAI) Meeting 2017, Vienna, Austria, November 23-25, 2017 33. Hufnagl K, Braun N, Wagner S, Pacios LF, Wiederstein M, Wallner M, Hofstetter G, Roth-Walter F, Jensen-Jarolim E. Reduced allergenic potential of the major birch pollen allergen Bet v 1a with retinoic acid in the pocket, Austrian Society for Allergology and Immunology (OEGAI) Meeting 2017, Vienna, Austria, November 23-25, 2017 34. Kienast K, Hofstetter G , Czernohaus M, Dvorak Z, Jensen-Jarolim E, Roth-Walter F. Human lipocalin-2 binds quercetin, thereby hindering aryl hydrocarbon receptor activation, Austrian Society for Allergology and Immunology (OEGAI) Meeting 2017, Vienna, Austria, November 23-25, 2017 35. Pali-Schöll I, Roth-Walter F, Hofstetter G, Hann S, Ahlers S, Moussa Afify S, Vercelli D, von Mutius E, Jensen-Jarolim E. Identification of the cows’ milk protein beta-lactoglobulin in stable dust: potential implications for the allergy- and asthma-protective effect,

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

Austrian Society for Allergology and Immunology (OEGAI) Meeting 2017, Vienna, Austria, November 23-25, 2017 36. Pranger CL, Gotovina J, Jensen AN, Wagner S, Kothgassner OD, Palme R, Larenas- Linnemann D, Singh J, Mösges R, Mothes-Luksch N, Glenk LM, Jensen-Jarolim E. Influence of acute stress on allergy and immune system: clinical study using the Trier Social Stress Test (TSST), Austrian Society for Allergology and Immunology (OEGAI) Meeting 2017, Vienna, Austria, November 23-25, 2017 37. Ghandizadeh S, Mothes-Luksch N, Jensen AN, Kundi M, Jensen-Jarolim E. Molecular features of allergens and their relationship with clinical history by clustering and multivariate statistical methods, Austrian Society for Allergology and Immunology (OEGAI) Meeting 2017, Vienna, Austria, November 23-25, 2017

Enikö Kallay 1. Elajnaf T, Frick A, Baumgartner-Parzer S, Kallay E: Intestinal organoids as a model to study calcium-sensing receptor function. 3rd International Symposium on the Calcium- sensing receptor, Florence, Italy, May 11-13, 2017 2. Iamartino L, Heffeter P, Baumgartner-Parzer S, Kallay E: The impact of the calcium sensing receptor in colorectal tumor growth. 3rd International Symposium on the Calcium-sensing receptor, Florence, Italy, May 11-13, 2017 3. Cichoń MA, Enyedi Á, Kállay E: Effect of Selumetinib on the Expression of Calcium ATPases in Colorectal Cancer. Retreat Center for Pathophysiology, Infectiology and Immunology, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria, September 19, 2017. 4. Thapa HB, Längle J, Kallay E. Role of Calcium Sensing Receptor in Inflammation; Retreat Center for Pathophysiology, Infectiology and Immunology, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria, September 19, 2017 5. T. Elajnaf, Kallay E “The calcium-sensing receptor in the intestines: signalling and clinical application”. Retreat Center for Pathophysiology, Infectiology and Immunology, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria, September 19, 2017 6. L. Iamartino, Kallay E "The impact of the Calcium-sensing receptor in colorectal tumor growth". Retreat Center for Pathophysiology, Infectiology and Immunology, Bernhard Gottlieb University Clinic of Dentistry, Vienna, Austria, September 19, 2017 7. T. Elajnaf, A. Frick, E. Kallay: Intestine-specific calcium-sensing receptor signalling. 13th YSA Symposion, Vienna, Austria, June 8-9, 2017 8. Iamartino L, Heffeter P, Kallay E.: CaSR therapeutics for colorectal cancer. 13th YSA Symposion, Vienna, Austria, June 8-9, 2017

Yan Ma 1. Ma Y. Evaluation of the effect of Chinese herbal medicine on myocardial infarction, prostate cancer and depression. “Sino-Austrian TCM research on lifestyle related diseases” conference. China Academy of Chinese Medical Sciences. Beijing, China. May 22, 2017 2. He S, Lyu F, Lou L, Wang-Mattes S, Li S, Ma Y. Analysis of novel therapeutic approaches and protential diagnostic markers in prostate cancer. 12th The Young Scientist Association (YSA) PhD-Symposium. Medical University of Vienna, Vienna, Austria, June 8 - 9, 2017. 3. Ma Y, He S, Lyu F, Lou L, Liu L, Li S, Jakowitsch J. Anti-tumor activities of Panax quinquefolius saponins and potential diagnostic markers in prostate cancer. 5th Global Congress on Prostate Cancer. Lisbon, Portugal, June 28-30, 2017,

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

4. He S, Lyu F, Lou L, Liu L, Li S, Jakowitsch J, Ma Y. Anti-tumor activities of Panax quinquefolius saponins and potential diagnostic markers in prostate cancer. 21st International Congress of Phytopharm 2017 and 10th Anniversary of the TCM Research Center Graz, Graz, Austria, July 2-5, 2017

g) Teaching Scripts and Books: n = 8

Yan Ma 1. M4 - Klinische Observation in Österreich 2. M4 - Orthopädie in der TCM 3. M4 - Einführung in die medizinische chinesische Fachsprache und Kultur (4) 4. M4 - Chirurgie in der TCM 5. M3 - Innere Medizin in der TCM 6. M5 - Tuina und Massage 7. M5 - Einführung in die Medizinische chinesische Fachsprache und Kultur (5) 8. M5 - Klinische Observation in China

h) Articles in Medical Journals: n = 0

i) Public activity

Press releases

Erika Jensen-Jarolim 1. Wie Allergiefaktoren KrebspatientInnen helfen können, February 15, 2017  https://www.vetmeduni.ac.at/de/infoservice/news/detail/artikel/2017/02/15/allergoonkologie/ 2. Frauen leiden öfter und heftiger unter Allergien und mehr unter Asthmasymptomen als Männer, March 8, 2017  https://www.ots.at/presseaussendung/OTS_20170307_OTS0020/frauen-leiden-oefter-und-heftiger- unter-allergien-und-mehr-unter-asthmasymptomen-als-maenner  http://science.apa.at/rubrik/medizin_und_biotech/Frauen_leiden_oefter_und_heftiger_unter_Allergi en_und_mehr_unter_Asthmasymptomen_als_Maenner/SCI_20170307_SCI39451352234845286 3. APA: Passivrauchen: Acrolein hemmt die Immunabwehr und kurbelt so das Tumorwachstum an, March 24, 2017  https://www.ots.at/presseaussendung/OTS_20170324_OTS0038/passivrauchen-acrolein-hemmt- die-immunabwehr-und-kurbelt-so-das-tumorwachstum-an  http://science.apa.at/rubrik/medizin_und_biotech/Passivrauchen_Acrolein_hemmt_die_Immunabwe hr_und_kurbelt_so_das_Tumorwachstum_an/SCI_20170324_SCI39451352235162138 4. Heuschrecke, Zikade, Käfer und Co. am Teller: neue Leitlinie für essbare Insekten des BMGF gemeinsam mit Vetmeduni Vienna, April 19, 2017  https://www.vetmeduni.ac.at/de/infoservice/presseinformationen/presseinformationen- 2017/insektenleitlinie/  http://www.science.apa.at/rubrik/kultur_und_gesellschaft/Neue_Leitlinie_fuer_essbare_Insekten_de s_BMGF_gemeinsam_mit_Vetmeduni_Vienna/SCI_20170419_SCI39431352635587084  http://www.science.apa.at/rubrik/natur_und_technik/Kaefer_am_Teller_Neue_Leitlinie_fuer_Insekte n_als_Nahrungsmittel/SCI_20170419_SCI39391351435588326

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

5. Ähnlichkeiten bei Lebensmittelallergien von Tier und Mensch: Der Vergleich macht uns (un)sicher, August, 23, 2017  https://science.apa.at/site/medizin_und_biotech/detail.html?key=SCI_20170823_SCI39451352237 734188

TV & Radio

Erika Jensen-Jarolim 1. ORF III, Themenmontag, Gesunde Geschäfte, November 20, 2017, http://tvthek.orf.at/profile/Themenmontag/13687392/ORF-III-Themenmontag-Gesunde- Geschaefte/13953965 2. ORF 2, ZIB1, International Women’s Day, March 8, 2017, http://tvthek.orf.at/profile/ZIB- 1/1203/ZIB-1/13920005/Gender-Gap-bei-Allergien/14000100 3. SiriusXM, Sirius Doctor Radio on the air, March 28, 2017 with Frank Adams, New York 4. Ö1 Morgenjournal and short version in the regional Ö3/Ö1 news, radio report, November 29, 2017, Warum Frauen doppelt so oft Asthma haben by Elke Ziegler

Isabella Pali-Schöll 1. ORF 2, Tierzuliebe (by Maggie Entenfellner), Allergies in Men and Animals, September 11, 2017. October 27, 2017

Articles in print media

1. Wie Allergiefaktoren KrebspatientInnen helfen können

2. Frauen leiden öfter und heftiger unter Allergien und mehr unter Asthmasymptomen als Männer  Ärzte Woche, Hormone machen vulnerabel, 11/2017, page 19  Heute Zeitung, March 8, 2017, Auto, belesen und politisch aktiv, So arbeiten, so leben Wiens Frauen, page 12  Tiroler Tageszeitung, March 8, 2017, 8. März: Walk of Farne in Innsbruck, page 3  Infoscreen, March 7, 2017, Frauen sind anfälliger für Allergien, page 99/100  Kleine Zeitung Steiermark + Graz, March 11, 2017, Wenn die atemwege dicht machen, page 8/9  Kurier (Wien), March 8, 2017, Frauen leiden heftiger unter Allergien, page 21  Wiener Zeitung, March 8, Frauen und Allergien, page 25  Oberösterreichische Nachrichten, March 8 2017, Allergien: MehrFrauen betroffen, page 15  Die Presse, March 10, 2017, Von diesen Pollen geht die stärkste Belastung aus, page11  Die Presse, March 11, 2017, Frauen leiden öfter und mehr an Allergien, page 33  Die ganze Woche, March 14, 2017, Östrogene fördern Heuschnupfen, Volume 11/17, page 71-73

3. Passivrauchen: Acrolein hemmt die Immunabwehr und kurbelt so das Tumorwachstum an  Doktor in Wien, Passivrauchen: Acrolein hemmt die Immunabwehr gegen Tumore, 05_2017, page 33  Die Presse, March 24, 2017, Tumorrisiko bei Passivrauchern, page 32

4. Heuschrecke, Zikade, Käfer und Co. am Teller: neue Leitlinie für essbare Insekten des BMGF  Die Furche, April 20, 2017, An kleinen Krabblern knabbern, page 24  Welche Haustiere wir haben, und welche wir haben sollten, viele Allergien sind in die Wiege gelegt, Wiener Bezirkszeitung, April 19-20, 2017, page 32 25

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

 Neues Volksblatt, April 20, 2017, Leitlinie für Insekten als Nahrungsmittel, page 18  Tiroler Tageszeitung, April 20, 2017, Ein Käfer als Snack zwischendurch, page 23  TT Kompakt, April 20, 2017,Leitlinie für Insekten als Nahrungsmittel, page 26  Kleine Zeitung, April 23, 2017,Heimchen am Herd, page 12  Neue Vorarlberger Tageszeitung, April 23, 2017,Heimchen am Herd  Kurier,May 2, 2017, Das Superfood der Zukunft, page 8  Forschen & Entdecken, „Keine Angst vor dem Frühling. Allergie-Abwehr aus dem Labor“ 2017; 01:6-11 and online: https://inwien.at/fileadmin/user_upload/ePaper/forschen-entdecken-2017- 01/index.html#/html5///page/10.

5. Ähnlichkeiten bei Lebensmittelallergien von Tier und Mensch: Der Vergleich macht uns (un)sicher  Salzburger Nachrichten, August 25, 2017, Auch unsere Haustiere leiden an Allergien, page 21  Brazilian health magazine „Saúde“,September 11, 2017, Written interview on the topic Comparing food allergies in men and animals  Mein Haustier, November/December 2017, Wenn Essen krank macht. Vergleichende Forschung zu Nahrungsmittelallergienmbei Mensch und Tier, p 20-22  Breeder Special, 2017, Wenn Essen krank macht, vergleichende Forschung zu Nahrungsmittelallergien bei Mensch und Tier, in press

Press outside Press Releases

Erika Jensen-Jarolim  Kurier, Themenwoche Allergien (Red. Theresa Girardi), March 6, 2017, Vererbte Überempfindlichkeit – Das Immunsystem trainieren, page 5-7  Der Tagesspiegel, September 18, 2017, Umzug der Bencard Allergie: Hochkarätiges Symposium in der neuen Firmenzentrale  CliniCum Pneumo, June 2017, by Michaela Steiner, Moderne Formen der Allergiediagnose, Volume 4/17  Touch Newspaper, May 2017, by Anouk Broersma, Hypoallergenic Cats  Die ganze Woche, March 2017, by Mag. Doris Schwander, Allergie und Hormone  Journal cover in Allergologie: Jensen-Jarolim E, Gender Effekte in der Allergologie, ein Update. March, 2017  Journal cover in Metallomics: Roth-Walter et at, Linking iron-deficiency with allergy, November 9, 2017  Journal cover in Allergy: Jensen-Jarolim et at, AllergoOncology – the impact of allergy in oncology, June 2017

Public Relation Activity

Erika Jensen-Jarolim  BioNanonet Folder, 1st Edition 2017, Chapter Health Safety Medicine, Immunological characterization of novel nanoparticulate formulations, page 21  Newsletter oft The European Academy of Allergy And Clinical Immunology, Issue 47, Volume 2, 2017, Science in brief, EAACI Position Paper on AllergoOncology: The role of allergy mechanisms in cancer, page 26, http://www.eaaci.org/resources/eaaci-newsletter/699-eaaci-newsletter- archive/1998-eaaci-newsletter-archive.html  Newsletter oft The European Academy of Allergy And Clinical Immunology, Issue 47, Volume 2, 2017, Science in brief, EAACI Position Paper on AllergoOncology: Allergens in veterminay medicine, page 27, http://www.eaaci.org/resources/eaaci-newsletter/699-eaaci-newsletter- archive/1998-eaaci-newsletter-archive.html

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

 Newsletter oft The European Academy of Allergy And Clinical Immunology, Issue 48, 2017, Science in brief, EAACI Position Paper on Comparing food allergy in humans and companion animals  MiniMed of the Medical University Vienna, April 25, 2017, Welche Haustiere wir haben und welche wir haben sollten

Yan Ma  Yan Ma, Shan He, Ulrike Loidl (2017-07-18). Traditionelle Chinesische Medizin (TCM) & chinesische Kultur. Workshop Kinderuni Wien/Medizinische Universität Wien. AKH, Wien.

Eva Untersmayr-Elsenhuber  Eva Untersmayr-Elsenhuber (217-07-30) You tube video anlässlich des FFG Talente Schülerpraktikums in der Arbeitsgruppe https://www.youtube.com/watch?v=ZsSZkam4b4k  Eva Untersmayr-Elsenhuber (2017-04-16). Nahrungsmittelallergie – Eine harte Nuss zu knacken. Video im Rahmen des FWF Wissenschaftskommunikationsprojektes WKP039. https://www.meduniwien.ac.at/hp/nahrungsmittelallergie/unser-darm/  Eva Untersmayr-Elsenhuber (2017-03-10). Mein Beruf: Ärztin und Forscherin. Einblicke in die Funktion des Immunsystems. Schulbesuch im Rahmen des FWF Wissenschaftskommunikationsprojektes WKP039 als Botschafterin von Science direct des OeAD. Neue Mittelschule Schlossstraße, Salzburg.  Eva Untersmayr-Elsenhuber (2017-01-23). Gesunde Ernährung bei Nahrungsmittelallergien und – Unverträglichkeiten. You tube video im Rahmen des FWF Wissenschaftskommunikationsprojektes WKP039. https://www.youtube.com/watch?v=rcogYBdEuwI

Online Articles

Erika Jensen-Jarolim 1. Wie Allergiefaktoren KrebspatientInnen helfen können  www.mein-allergie-portal.com, January 30, 2017, AllergoOnkologie: Immunologie – Allergie- Onkologie: Was sind die Zusammenhänge? By S. Jossé, https://www.mein-allergie- portal.com/allergie-allgemein/1065-allergoonkologie-immunologie-allergie-onkologie-was-sind-die- zusammenhaenge.html

2. Frauen leiden öfter und heftiger unter Allergien und mehr unter Asthmasymptomen als Männer  www.krone.at, March 7, 2017, Hormone sind schuld: Frauen leiden öfter und heftiger unter Allergien, http://www.krone.at/557780  heilpraxisnet.de, March 9, 2017, Studie: Frauen leiden viel öfter und heftiger unter Allergien http://www.heilpraxisnet.de/naturheilpraxis/studie-frauen-leiden-viel-oefter-und-heftiger-unter- allergien-20170309221901  gesund.at, March 8, 2017, Allergien und Asthma treffen Frauen häufiger, http://www.gesund.at/a/frauen-allergie-asthma  health.economictimes.indiatimes.com, March 8, 2017, Women suffer from asthma symptoms  more frequently and more severely than men, https://health.economictimes.indiatimes.com/news/industry/women-suffer-from-asthma-symptoms- more-frequently-and-more-severely-than-men/57528672  aponet.de, March 8, 2017, Frauen leiden häufiger unter Asthma und Allergien, https://www.aponet.de/aktuelles/forschung/20170308-frauen-leiden-haeufiger-unter-asthma-und- allergien.html  nachrichten.at, March 8, 2017, Allergien: Mehr Frauen betroffen, http://www.nachrichten.at/nachrichten/gesundheit/Allergien-Mehr-Frauen-betroffen;art114,2504753  aha.ch, March 08, 2017, Frauen leiden öfter und heufiger unter Allergien, https://www.aha.ch/allergiezentrum- schweiz/Aktuelles/Archiv/?oid=1642&lang=de&news_eintragId=803  alphagalileo.org, March 7, 2017, Frauen leiden öfter und heftiger unter Allergien und mehr unter 27

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

Asthmasymptomen als Männer, http://www.alphagalileo.org/ViewItem.aspx?CultureCode=de&ItemId=173222  news.at, March 7, 2017, Frauen leiden öfter und heftiger unter Allergien, https://www.news.at/a/frauen-leiden-oefter-und-heftiger-unter-allergien-8021514  orf.at, March 7, 2017, Frauen sind anfälliger für Allergien, http://wien.orf.at/news/stories/2829539/

 derstandard.at, March 7, 2017, Frauen leiden häufiger und heftiger unter Allergien, http://derstandard.at/2000053718586/Frauen-leiden-haeufiger-und-heftiger-unter-Allergien  beforeitsnews.com, March 7, 2017, Women Suffer from Asthma Symptoms More Frequently and More Severely Than Men, http://beforeitsnews.com/health/2017/03/women-suffer-from-asthma- symptoms-more-frequently-and-more-severely-than-men-2723292.html  medmix.at, March 7, 2017, Frauen leiden öfter und heftiger an Allergien und Asthma, http://www.medmix.at/frauen-leiden-oefter-heftiger-allergien-asthma/  ineffableisland.com, March 7, 2017, Women Suffer from Asthma Symptoms More Frequently and More Severely Than Men, http://www.ineffableisland.com/2017/03/women-suffer-from-asthma- symptoms-more.html  www.healthmedicinet.com, March 7, 2017, Women suffer from asthma symptoms more frequently and more severely than men, http://healthmedicinet.com/i/women-suffer-from-asthma-symptoms- more-frequently-and-more-severely-than-men/  myinforms.com, March 7, 2017, Women suffer from asthma symptms more frequently and more severely than men, http://myinforms.com/en-us/a/131444601-women-suffer-from-asthma- symptoms-more-frequently-and-more-severely-than-men/  medicalexpress.com, March 7, 2017, Women suffer from asthma symptoms more frequently and more severely than men, https://medicalxpress.com/news/2017-03-women-asthma-symptoms- frequently-severely.html  allergievermeidung.org, March 7, 2017, Allergien & Asthma: Frauen leiden mehr, http://www.allergenvermeidung.org/newseintrag/allergien-asthma-frauen-leiden-mehr.html  studium.at, March 7, 2017, Frauen leiden öfter und heftiger unter Allergien, http://www.studium.at/539757-frauen-leiden-oefter-und-heftiger-unter-allergien  netdoktor.at, March 15, Bei Asthma gibt es keine Chancengleichheit (von Larissa Melville), https://www.netdoktor.de/magazin/bei-asthma-gibt-es-keine-chancengleichheit/  science.orf.at, November 29, 2017, Warum Frauen doppelt so oft Asthma haben, http://science.orf.at/stories/2880819

3. Passivrauchen: Acrolein hemmt die Immunabwehr und kurbelt so das Tumorwachstum an  Alphagalileo.org, March 24, 2017, Passivrauchen: Acrolein hemmt die Immunabwehr und kurbelt so das Tumorwachstum an, http://www.alphagalileo.org/ViewItem.aspx?CultureCode=de&ItemId=173842  derstandard.at, March 24, 2017, Zwei bis drei Österreicher sterben täglich durch Passivrauchen - derstandard.at/2000054760866/Zwei-bis-drei-Oesterreicher-sterben-taeglich-durch-Passivrauchen, http://derstandard.at/2000054760866/Zwei-bis-drei-Oesterreicher-sterben-taeglich-durch- Passivrauchen  diepresse.com, March 24, 2017, Tumorrisiko bei Passivrauchern, http://diepresse.com/home/science/5189584/Tumorrisiko-bei-Passivrauchern  laborpraxis.voge.de, March 24, 2017, Warum Passivrauchen ähnlich schädlich ist wie das Ausblasen einer Kerze, http://www.laborpraxis.vogel.de/bioanalytik-pharmaanalytik/articles/593583/  medicalxpress.com, March 24, 2017, Passive smoking—acrolein inhibits immune response, hence accelerating tumour growth, https://medicalxpress.com/news/2017-03-passive-smokingacrolein- inhibits-immune-response.html  studium.at, March 24, 2017, Passivrauchen: Acrolein hemmt die Immunabwehr, http://www.studium.at/548784-passivrauchen-acrolein-hemmt-die-immunabwehr  salzburg.24.at, March 24, 2017, Passivrauchen: Acrolein hemmt die Immunabwehr, http://www.salzburg24.at/passivrauchen-acrolein-hemmt-die-immunabwehr/4959320

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

 myinforms.com, March 24, 2017, passive smoking: acrolein inhibits immune response hence accelerating tumor growth, http://myinforms.com/en-us/a/200847660-passive-smokingacrolein- inhibits-immune-response-hence-accelerating-tumour-growth/  news-medical.net, March 25, 2017, Exposure to acrolein causes failure of immune defence to tumours, study finds, http://www.news-medical.net/news/20170325/Exposure- to-acrolein-from-passive-smoking-causes-failure-of-immunec2a0defencec2a0toc2a0tumours-study- finds.aspx  sciencedaily.com, March 24, 2017, Passive smoking: Acrolein inhibits immune response, hence accelerating tumor growth, https://www.sciencedaily.com/releases/2017/03/170324105412.htm  meduniwien.ac.at, March 24, 2017, Passive smoking: acrolein inhibits immune response, hence accelerating tumour growth, https://www.meduniwien.ac.at/web/en/about- us/news/detailseite/2017/news-in-march-2017/passive-smoking-acrolein-inhibits-immune-response- hence-accelerating-tumour-growth/

4. Heuschrecke, Zikade, Käfer und Co. am Teller: neue Leitlinie für essbare Insekten des BMGF  Heute.at, April 20, 2017, Politik erlässt Regeln für Insektenverzehr, http://www.heute.at/politik/news/story/Politik-erlaesst-Regeln-fuer-Insektenverzehr-46537315  Dr.-vet.net, Juni 21, 2017, Leitlinie für essbare Insekten, http://www.dr-vet.net/vet-report- kurzmeldungen/artikel/oesterreich-leitlinie-fuer-essbare-insekten.html  tt.com, April 20, 2017, Ein Käfer als Snack zwischendurch, http://www.tt.com/lebensart/12878380- 91/ein-k%C3%A4fer-als-snack-zwischendurch.csp  Help.orf.at, April 19, 2017, Neue Leitlinie für essbare Insekten, http://help.orf.at/stories/2837929/  Nachrichten.at, April 19, 2017, Käfer am Teller: Neue Leitlinie für Insekten als Nahrungsmittel, http://www.nachrichten.at/nachrichten/chronik/Kaefer-am-Teller-Neue-Leitlinie-fuer-Insekten-als- Nahrungsmittel;art58,2544266  Volksblatt.at, April 19, 2017, Neue Leitlinie für Insekten als Nahrungsmittel, http://www.volksblatt.at/apa_news/?tx_posapaxmlimport_pinews%5Buid%5D=159747  Derstandard.at, April 19, 2017, Neue Leitlinie für Insekten als Nahrungsmittel, http://derstandard.at/2000056174572/Oesterreich-Neue-Leitlinie-fuer-Insekten-als-Nahrungsmittel  Unsertirol24.com, Apirl 19, 2017, Neue Leitlinie für Insekten als Nahrungsmittel, http://www.unsertirol24.com/2017/04/19/neue-leitlinie-fr-insekten-als-nahrungsmittel/  Salzburg.com, April 19, 2017, Leitlinie für Insekten als Nahrungsmittel, http://www.salzburg.com/nachrichten/oesterreich/chronik/sn/artikel/neue-leitlinie-fuer-insekten-als- nahrungsmittel-243870/  Suedtirolnews.it, April 19, 2017, Neue Leitlinie für Insekten als Nahrungsmittel, https://www.suedtirolnews.it/unterhaltung/wer-haette-das-gedacht/neue-leitlinie-fuer-insekten-als- nahrungsmittel  Osttirol-online.at, Aprl 19, 2017, Neue Leitlinie für Insekten als Nahrungsmittel, http://www.osttirol- online.at/aktuelles/welt-news/164904-neue-leitlinie-fuer-insekten-als-nahrungsmittel.html  Vol.at, April 19, 2017, Neue Leitlinie für Insekten als Nahrungsmittel, http://www.vol.at/neue-leitlinie- fuer-insekten-als-nahrungsmittel/apa-1435588150  Vienna.at, April 19, Neue Leitlinie für Insekten als Nahrungsmittel, http://www.vienna.at/neue- leitlinie-fuer-insekten-als-nahrungsmittel/apa-1435588150  Salzburg24.at, April 19, 2017, Neue Leitlinie für Insekten als Nahrungsmittel, http://www.salzburg24.at/neue-leitlinie-fuer-insekten-als-nahrungsmittel/apa-1435588150  Wirkochen.at, April 19, 2017, Neue Leitlinie für Insekten als Nahrungsmittel, http://www.wirkochen.at/gourmet-news/Neue-Leitlinie-fuer-Insekten-als-Nahrungsmittel/278754834

5. Ähnlichkeiten bei Lebensmittelallergien von Tier und Mensch: Der Vergleich macht uns (un)sicher  Biermann-medizin.de, Augugst 23, 2017, Der Vergleich Tier und Mensch macht uns (un)sicher, http://www.biermann-medizin.de/fachbereiche/allgemeinmedizin/medizin-forschung/vergleich-tier- mensch-macht-uns-unsicher

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

 Medicalxpress.com, Augugst 23, 2017, Food allergies—animals and humans may have more in common than you think, https://medicalxpress.com/news/2017-08-food-allergiesanimals-humans- common.html  Eurekalert.org, Augugst 23, 2017, Comparing food allergies: Animals and humans may have more in common than you think, https://www.eurekalert.org/pub_releases/2017-08/uovm-cfa082317.php  Newsdog.today, Augugst 23, 2017, Food allergies may affect your pet dogs, cats too, http://newsdog.today/a/article/599ee43f1290717e6f3b03f5/?d=false  Medizin-aspekte.de, Augugst 23, 2017, Ähnlichkeiten bei Lebensmittelallergien von Tier und Mensch: Der Vergleich macht uns (un)sicher, https://medizin-aspekte.de/95857-aehnlichkeiten-bei- lebensmittelallergien-von-tier-und-mensch-der-vergleich-macht-uns-unsicher/  Idw-online.de, Augugst 23, 2017, Ähnlichkeiten bei Lebensmittelallergien von Tier und Mensch: Der Vergleich macht uns (un)sicher, https://idw-online.de/de/news679803  Idw-online.de, Augugst 23, 2017, Comparing food allergies: Animals and humans may have more in common than you think, https://idw-online.de/de/news679804  Medizin-aspekte.de, Augugst 23, 2017, Comparing food allergies: Animals and humans may have more in common than you think, https://medizin-aspekte.de/95856-comparing-food-allergies- animals-and-humans-may-have-more-in-common-than-you-think/  Extremnews.com, Augugst 23, 2017, Ähnlichkeiten bei Lebensmittelallergien von Tier und Mensch: Der Vergleich macht uns (un)sicher, https://www.extremnews.com/berichte/gesundheit/5fca166750e3209  Sciencedaily.com, Augugst 23, 2017, Comparing food allergies: Animals and humans may have more in common than you think, https://www.sciencedaily.com/releases/2017/08/170823094121.htm  Alphagalileo.org, Augugst 23, 2017, Food allergies: Animals and humans may have more in common than you think, http://www.alphagalileo.org/ViewItem.aspx?ItemId=178299&CultureCode=en  Open PR.de, Augugst 23, 2017, Ähnlichkeiten bei Lebensmittelallergien von Tier und Mensch: Der Vergleich macht uns (un)sicher, http://www.openpr.de/news/964727/aehnlichkeiten-bei- Lebensmittelallergien-von-Tier-und-Mensch-Der-Vergleich-macht-uns-un-sicher.html  Open PR.de, Augugst 23, 2017, Comparing food allergies: Animals and humans may have more in common than you think, http://www.openpr.de/news/964726/Comparing-food-allergies-Animals- and-humans-may-have-more-in-common-than-you-think.html  JuraForum.de, Augugst 23, 2017, Comparing food allergies: Animals and humans may have more in common than you think, http://www.juraforum.de/wissenschaft/comparing-food-allergies-animals- and-humans-may-have-more-in-common-than-you-think-601563  JuraForum.de, Augugst 23, 2017, Ähnlichkeiten bei Lebensmittelallergien von Tier und Mensch: Der Vergleich macht uns (un)sicher, http://www.juraforum.de/wissenschaft/aehnlichkeiten-bei- lebensmittelallergien-von-tier-und-mensch-der-vergleich-macht-uns-unsicher-601564  Gears Of Biz.com, Augugst 23, 2017, Comparing food allergies: Animals and humans may have more in common than you think, http://gearsofbiz.com/comparing-food-allergies-animals-and- humans-may-have-more-in-common-than-you-think/23008  Gears Of Biz.com, Augugst 23, 2017, Symptoms, triggers of food intolerance found to be similar in animals and humans, http://gearsofbiz.com/symptoms-triggers-of-food-intolerance-found-to-be- similar-in-animals-and-humans/23071  Dotemirates.com, August 24, 2017, Food allergies—animals and humans may have more in common than you think, https://www.dotemirates.com/en/details/3826826?from=dot  HealthMedicineNetwork.com, August 24, 2017, Comparing Food Allergies: Animals And Humans May Have More in Common Than You Think, http://healthmedicinet.com/comparing-food-allergies- animals-and-humans-may-have-more-in-common-than-you-think/  Proplanta.de, August 24, 2017, Lebensmittelallergien von Tieren und Menschen vergleichbar, http://www.proplanta.de/Agrar-Nachrichten/Wissenschaft/Lebensmittelallergien-von-Tieren-und- Menschen-vergleichbar_article1503578794.html  ScienceNewsline.com, August 24, 2017, Comparing Food Allergies: Animals And Humans May Have More in Common Than You Think, http://www.sciencenewsline.com/news/2017082317450073.html

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

 Lab ManagerMagazine.com, August 24, 2017, Comparing Food Allergies: Animals and Humans May Have More in Common Than You Think, http://www.labmanager.com/news/2017/08/comparing-food-allergies-animals-and-humans-may- have-more-in-common-than-you-think  DailyWorld.in, August 24, 2017, Food allergies may affect your pet dogs, cats too - Daily World, http://dailyworld.in/food-allergies-may-affect-your-pet-dogs-cats-too/  VijayaBheri.com, August 24, 2017, Food allergies may affect your pet dogs, cats too, http://vijayabheri.com/food-allergies-may-affect-your-pet-dogs-cats-too/  Andhravilas.net, August 24, 2017, Food allergies may affect your pet dogs, cats too, http://www.andhravilas.net/en/Food-allergies-may-affect-your-pet-dogs-cats-too  BusinessStandard.com, August 24, 2017, Food allergies may affect your pet dogs, cats too, http://www.business-standard.com/article/news-ians/food-allergies-may-affect-your-pet-dogs-cats- too-117082401090_1.html  NetIndia123.com, August 24, 2017, Food allergies may affect your pet dogs, cats too, http://www.netindia123.com/articles/showdetails.asp?id=3174695  Webindia123.com, August 24, 2017, Food allergies may affect your pet dogs, cats too, https://news.webindia123.com/news/Articles/Health/20170824/3174695.html  Yahoo! India News, August 24, 2017, Food allergies may affect your pet dogs, cats too, https://in.news.yahoo.com/food-allergies-may-affect-pet-dogs-cats-too-135004032.html  MentalFloss.com, August 24, 2017, Animal Food Allergies May Be More Common Than We Think, http://mentalfloss.com/article/503915/animal-food-allergies-may-be-more-common-we-think  FeedStuffs.com, August 24, 2017, Comparing food allergies: Animals, people may have more in common than thought, http://www.feedstuffs.com/news/comparing-food-allergies-animals-people- may-have-more-common-thought  FeedStuffs.com, August 24, 2017, Food allergies: Animals, people may have more in common than thought, http://www.feedstuffs.com/news/food-allergies-animals-people-may-have-more-common- thought  Suryaa.com, August 24, 2017, Food allergies may affect your pet dogs and cats, http://www.suryaa.com/17888-food-allergies-may-affect-your-pet-dogs-and-cats.html  NRIPress.com, August 24, 2017, Food allergies may affect your pet dogs, cats too, http://nripress.com/food-allergies-may-affect-your-pet-dogs-cats-too/  NutritionInsight.com, August 24, 2017, Food allergies also leave animals suffering, says study, http://www.nutritioninsight.com/news/food-allergies-also-leave-animals-suffering-says-study.html  CanindiaNews.com, August 24, 2017, Food allergies may affect your pet dogs, cats too, http://www.canindia.com/food-allergies-may-affect-your-pet-dogs-cats-too/  TheIndianExpress.com, August 24, 2017, Food allergies may affect your pets, http://indianexpress.com/article/lifestyle/life-style/food-allergies-may-affect-your-pets-4813127/  MSN South Africa, August 25, 2017, Animal food allergies may be more common than we think, http://www.msn.com/en-za/lifestyle/lifestyleanimalplanet/animal-food-allergies-may-be-more- common-than-we-think/ar-AAqG6rF  Times-mumbai.com, August 25, 2017, Food allergies may affect your pets, http://www.times- mumbai.com/food-allergies-may-affect-your-pets/  Schattenblick,de, August 25, 2017, VETERINÄR/444: Ähnlichkeiten bei Lebensmittelallergien von Tier und Mensch (idw), http://www.schattenblick.de/infopool/tiere/fakten/tfvet444.html  NewsX.com, August 25, 2017, Food allergies may affect your pet dogs, cats too, http://www.newsx.com/health-and-environment/73136-food-allergies-may-affect-your-pet-dogs- cats-too  TheHansIndia.com, August 25, 2017, Food allergies may affect your pet dogs, cats too, http://www.thehansindia.com/posts/index/Life-Style/2017-08-25/Food-allergies-may-affect-your-pet- dogs-cats-too/321721  Siasat Daily.com, August 25, 2017, Food allergies may affect your pet dogs, cats too, http://www.siasat.com/news/food-allergies-may-affect-pet-dogs-cats-1226862/

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

 News18.com, August 25, 2017, Food Allergies May Affect Your Pet Dogs, Cats Too, http://www.news18.com/news/lifestyle/health-and-fitness-food-allergies-may-affect-your-pet-dogs- cats-too-1501271.html  The Economic Times – Indiatimes.com, August 26, 2017, Caution, animal lovers! Your pet might be suffering from food allergy, http://economictimes.indiatimes.com/magazines/panache/caution- animal-lovers-your-pet-might-be-suffering-from-food-allergy/articleshow/60230111.cms  Kolkata24x7.com, August 26, 2017, Food Allergies May Affect Your Pet Dogs, Cats Too, https://english.kolkata24x7.com/lifestyle/food-allergies-may-affect-pet-dogs-cats  The National.ae, August 27, 2017, Food allergies may affect your pet dogs, cats too, https://www.thenational.ae/lifestyle/wellbeing/food-allergies-may-affect-your-pet-dogs-cats-too- 1.623369  IOL.co.za, August 28, 2017, Food allergies may affect your pet dogs, cats too, https://www.iol.co.za/lifestyle/family/food-allergies-may-affect-your-pet-dogs-cats-too-10967690  Foodandwine.com, August 28, 2017, Our Pets Are Developing More Food Allergies, Too, http://www.foodandwine.com/news/humans-pets-food-allergies  SciencesetAvenir.fr, August 28, 2017, Une étude compare les allergies alimentaires humaines et animales, https://www.sciencesetavenir.fr/sante/comparaison-des-allergies-alimentaires-les- animaux-et-les-humains-ont-de-nombreux-points-communs_115758  RocketNews.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://www.rocketnews.com/2017/08/food-allergies-can-hit-your-four-legged-friends-too/  Thesouthern.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://thesouthern.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_742d9e8c-3a0e-5331-85d1-f14a39de0b96.html  WinonaDailyNews.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://www.winonadailynews.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four- legged-friends-too/article_e906b3a2-483d-52b3-8297-e2524d3780ad.html  Nwitimes.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://www.nwitimes.com/niche/get-healthy/food-allergies-can-hit-your-four-legged-friends- too/article_7e5de044-1fdc-511c-9118-59c31ec9f8ad.html  Rapidcityjournal.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://rapidcityjournal.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_36fd4e98-05a5-590b-b1f5-57c69ee5d280.html  Philly.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://www.philly.com/philly/health/topics/HealthDay725861_20170901_Food_Allergies_Can_Hit_Y our_Four-Legged_Friends__Too.html  Madison.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://host.madison.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_5dcc0038-1d90-5025-bb7a-a8d00063ad66.html  NapaValleyRegister.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://napavalleyregister.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged- friends-too/article_928a3954-7dc3-5598-837e-bb939537f2d6.html  BillingsGazette.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://billingsgazette.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_60f144aa-d013-51c5-b54a-729a5ed2d2cc.html  TheWorldLink.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://theworldlink.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_862f4976-94ab-57d1-b076-665598eadf84.html  WiscNews.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://www.wiscnews.com/lifestyles/health-med-fit/article_7e58b291-3f57-58a7-8848- 72aceef1ce5b.html  BismarckTribune.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://bismarcktribune.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_9d569e70-c355-5467-9222-6e671c2edf0d.html  Cumberlink.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too | Health, Medicine and Fitness, http://cumberlink.com/lifestyles/health-med-fit/food-allergies-can-hit- your-four-legged-friends-too/article_b9e2fa33-abe1-5377-a50a-524dbd877b6e.html 32

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

 Lebanon-Express.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://lebanon-express.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged- friends-too/article_b7ef1857-7b02-5e75-8794-9caa91b3ead7.html  FremontTribune.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://fremonttribune.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_2211c2b2-5af8-5a59-bc03-52ea39eaa3e1.html  Tucson.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://tucson.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_adaa639d-8524-5e72-aca3-d111f6ce7b6e.html  Magicvalley.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://magicvalley.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_a796edbe-a1a3-5176-a6e5-e1c586c92022.html  MTStandard.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://mtstandard.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_a79a51e6-0407-5471-9abb-a6ee500bf7c5.html  ColumbusTelegram.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://columbustelegram.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged- friends-too/article_67ebbeea-5ed2-5d41-9feb-f7d12bb46b5d.html  Pantagraph.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://www.pantagraph.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_608420b2-be2c-562f-b1c4-6c949a9c0aa3.html  Thetandd.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://thetandd.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_95d97bfb-eb4c-5c10-b0fd-d34d2e92cd3b.html  Trib.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://trib.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_0c69a41f-7d31-5a2c-a415-6d52c7a83ac7.html  Elkodaily.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://elkodaily.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_034a44b6-a836-50dd-931d-2ac2edaa5095.html  LaCrosseTribune.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://lacrossetribune.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_5bb8e9b6-a15a-5457-b489-79e8c6ee42ae.html  DemocratHerald.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://democratherald.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_88f2f02c-7712-59b0-bc65-eff46c7b6169.html  Missoulian.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://missoulian.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_3404e33f-fbbf-5c81-acab-1793b9a3466a.html  Wcfcourier.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://wcfcourier.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_b8cc8c8e-8117-5d20-b6ef-a009bafbdfc8.html  JournalStar.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://journalstar.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_142f3d24-2afe-5df5-9096-227acc701f14.html  Herald-Review.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://herald-review.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_a8d5f864-9343-5421-acc9-6136dbeb17ca.html  Jg-tc.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://jg- tc.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends-too/article_044b4a98- 019a-5fbb-92e9-69a96205fc56.html  AuburnPub.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://auburnpub.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_90c05144-89ff-59a3-8829-136dc93e6a45.html

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

 JournalTimes.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://journaltimes.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_387c950d-fa91-52d7-a7bf-bb3845e54790.html  PostStar.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://poststar.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_9aec5c45-d158-579c-b5a0-d86a8ac2d983.html  MuscatineJournal.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://muscatinejournal.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged- friends-too/article_da81b265-2e47-5fcb-9f6f-e190ef9843b9.html  TDN.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://tdn.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_fb99fcd2-928f-573d-b746-759ea40944a3.html  GlobeGazette.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://globegazette.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_0469edb2-d522-5c49-ab0c-ba24e3dd2b9d.html  LompocRecord.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://lompocrecord.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_489750f1-ec31-5bdd-aebd-d9d280f7fe39.html  RavalliRepublic.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://ravallirepublic.com/lifestyles/health-med-fit/article_611f3c94-ae3a-52e6-877d- 6884b9273622.html  HanfordSentinel.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://hanfordsentinel.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged-friends- too/article_e4f92215-0ae6-506f-9618-faf1d4a2b540.html  DailyJournalOnline.com, September 1, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://dailyjournalonline.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged- friends-too/article_734cd7e4-808a-5c02-8223-e313bae63b14.html  Consumer.healthday.com, September 1, 2017,Food Allergies Can Hit Your Four-Legged Friends, Too, https://consumer.healthday.com/respiratory-and-allergy-information-2/food-allergy-news- 16/food-allergies-can-hit-your-four-legged-friends-too-725861.html  Fleekist.com, September 2, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, https://www.fleekist.com/food-allergies-can-hit-your-four-legged-friends-too/  DoctorsLounge.com, September 2, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, https://www.doctorslounge.com/index.php/news/hd/74857  Hon.ch, September 2, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://www.hon.ch/News/HSN/725861.html  Maysville-online.com, September 2, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://www.maysville-online.com/lifestyles/health-med-fit/food-allergies-can-hit-your-four-legged- friends-too/article_abccf878-6e6c-5ac4-a3b2-e8cc307ae3e1.html  HealingWell.com, September 2, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://news.healingwell.com/index.php?p=news1&id=725861  EHEandMEcom, September 2, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, https://www.eheandme.com/news_articles/549682466  Drugs.com, September 2, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, https://www.drugs.com/news/food-allergies-can-hit-your-four-legged-friends-66884.html  Biglobe.ne.jp, September 3, 2017, https://news.biglobe.ne.jp/animal/0903/kpa_170903_9025297977.html  Excite.co.jp, September 3, 2017, http://www.excite.co.jp/News/odd/Karapaia_52244941.html  Gunosy.com, September 3, 2017, https://gunosy.com/articles/RP3Oc  Newsmax.co, September 5, 2017, Pets Can Have Food Allergies, Too, http://www.newsmax.com/Health/Health-News/pets-food-allergies/2017/09/05/id/811656/  Newsline.com, September 5, 2017, Pets Can Have Food Allergies, Too, https://newsline.com/pets- can-have-food-allergies-too/

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

 HealthMedicineNet.com, September 5, 2017, Pets Can Have Food Allergies, Too, http://healthmedicinet.com/i/pets-can-have-food-allergies-too/  Elbiruniblogspotcom.blogspot.ie, September 6, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, https://elbiruniblogspotcom.blogspot.ie/2017/09/food-allergies-can-hit-your-four- legged.html  BlackVillageJournal.com, September 6, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://blackvillagejournal.com/food-allergies-can-hit-your-four-legged-friends-too-medlineplus- health-news/  MedicineNet.com, September 7, 2017, Food Allergies Can Hit Your Four-Legged Friends, Too, http://www.medicinenet.com/script/main/art.asp?articlekey=206581  Mrcvs.co.uk, September 11, 2017, Study highlights similarities between human and animal food allergies, http://mrcvs.co.uk/en/news-story.php?id=16282  AnimalHealthMedia.com, September 18, 2017, Study highlights similarities between human and animal food allergies, http://animalhealthmedia.com/study-highlights-similarities-human-animal- food-allergies/  Qatar-Tribune.com, October 8, 2017, Food allergies may affect your pet dogs, cats too, http://www.qatar-tribune.com/news-details/id/88995

Eva Untersayr-Elsenhuber  Eva Untersmayr-Elsenhuber (2017-02-16). Ist es gesünder, sich glutenfrei zu ernähren? Interview für news.at.

1.1.2. Research Awards: n = 10

Erika Jensen-Jarolim 1. Jordakieva G, Best Presentation Prize, Annual Meeting oft he EAACI, Helsinki, Finland, for Thematic Poster Session 15: Immune responses in allergy and asthma 2. Gotovina J, travel award to 15th EAACI Immunology Winter School 2017 3. Fazekas-Singer J, Abstract Prize, Annual Meeting oft he EAACI, Helsinki, Finland, AllergoOncology: The canine IgE antibody ‘can225IgE-λ’ triggers strong and specific effector-cell mediated cytotoxicity against EGFR+ tumor cells 4. Gotovina J, Abstract Prize Annual Meeting oft he EAACI, Helsinki, Finland, Can acute stress dampen allergic reactions? Epinephrine induces a regulatory M2b-like macrophage phenotype, which attenuates cord blood-derived mast cells (CBMCs) degranulation in a human model of allergic inflammation 5. Afify-Moussa S, travel award to Annual Meeting oft he EAACI, Helsinki, Finland 6. Gotovina J, scholarship from ÖFG (Österreichische Forschungsgemeinschaft) for exchange program at St John’s Institute of Dermatology, Kings´College London, UK, October 5, 2017-November 30, 2017 7. Fazekas-Singer J, Boehringer Ingelheim Fonds travel award, King’s College London, March 4 - May 6, 2017

Franziska Roth-Walter 1. EAACI ePoster Prize for outstanding presentation of the eposter “Increased LCN2-levels after sublingual immunotherapy against house dust mites is associated with amelioration of symptoms” European Academy of Allergy and Clinical Immunology EAACI 2017, 17 - 21 June 2017; Helsinki, Finland 2. travel grant for "Internationale Kommunikation" of the Österreichische Forschungsgemeinschaft fort he EAACI congress in Helsinki, Finland

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

Yan Ma 1. Travel award: Sino-Austrian TCM research on lifestyle related diseases conference. China Academy of Chinese Medical Sciences. Beijing, China. May 22nd, 2017

1.1.3. Invited lectures: n = 29

Erika Jensen-Jarolim 1. Allergoids – Adjuvants: Challenges and Opportunities. Symposium Biologics in Allergy, German Society of Allergy and Clinical Immunology (DGAKI), Berlin, Germany, January 14-15, 2017 2. Aluminium in der Allergen Immmuntherapie, Scientific Advisory Meeting Bencard, München, Germany, March 17, 2017 3. AllergoOncology: Basic concepts and translational perspectives, Comparative Oncology Meeting: Mast Cell Neoplasms in Dogs and Men, Vienna, Austria, March 24, 2017 4. Molecular allergy diagnosis. 29. Mainzer Allergy Workshop, Mainz, Germany, March 29- 31, 2017 5. Is allergy female? Answers using molecular allergology, Rotary Workshop, Medical University Vienna, Vienna, Austria, April 4, 2017 6. Modern allergy diagnosis. Vienna Interdisciplinary Allergy Day, Medical University Vienna, Vienna, Austria, May 5, 2017 7. Adjuvants in AIT: the good, the bad, the ugly. WAO Symposium, HOT Topics in Allergy: Pediatric and Regulatory Aspects. Rome, Italy/Vatican City, April 27-29, 2017 8. Therapeutic interventions in the GI tract and their influence on food sensitizations and allergy, Keynote Lecture, Symposium, Research center Borstel, Germany, May 6, 2017 9. Molecular fingerprinting of complex allergoids, Symposium The Best Therapies By Design, Annual Congress of the European Academy of Allergy and Clinical Immunology (EAACI), Helsinki, Finland, June 18, 2017 10. AllergoOncology, an interdiciplinary concept, Inselspital Bern, Switzerland, August 29, 2017 11. Alternative Adjuvants and vaccine carriers, Company Opening Symposium, Munich, Germany, September 13, 2017 12. The concept of AllergoOncology, Annual Meeting of the German Society for Immunology (DGfI), Erlangen, Germany, September 14-16, 2017 13. Adjuvants in allergen immunotherapy – are there alternatives to alum? AllerGOlogie Symposium, Hamburg, Germany, September 22, 2017 14. Molecular Allergy diagnosis, Reinbeker Allergieseminar, Reinbek, Germany, November 30 – December 2, 2017

Isabella Pali-Schöll 1. Teaching project on the subject “food allergies” within “children’s university”, general hospital, Vienna, Austria, May 22, 2017 2. „Allergien: Welche Haustiere wir haben - und welche wir haben sollten“ (Allergies: The pets we have – and which we should have)“, MiniMed, Vienna, Austria, April 25, 2017 4. „Food allergies. Feed allergies. And now?“ at the KYNTegra Workshop, VetMedUni Vienna, Austria, November 19, 2017

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

5. „Insects as allergen source in food“, Herbsttagung der Tierärztlichen Vereinigung für Lebensmittelsicherheit und Tiergesundheit (TVL), Olten, Schweiz, November 23, 2017

Franziska Roth-Walter 1. Meeting of AllergoOncology TaskForce of the European Academy of Allergy and Clinical Immunology, Immunetolerance: Acrolein; Guy's Hospital Campus at London Bridge, London.

Enikö Kallay 1. “Krebs und Vitamin D. Wie ist der derzeitige Kenntnisstand?”, Fachtag Ernährung, Vienna, Austria, April 24, 2017 2. “The calcium-sensing receptor in colorectal cancer”, 3rd International CaSR Symposium, Florence, Italy, May 11-13, 2017

Yan Ma 1. Evaluation of the effect of Chinese herbal medicine on myocardial infarction, prostate cancer and depression. “Sino-Austrian TCM research on lifestyle related diseases” conference. China Academy of Chinese Medical Sciences. Beijing, China. May 22nd, 2017 2. Anti-tumor activities of Panax quinquefolius saponins and potential diagnostic markers in prostate cancer. 5th Global Congress on Prostate Cancer. June 29th 2017, Lisbon, Portugal. 3. Was sind Chinesische Medizin und Chinesische Kultur? Kinderuni Wien 2016. Vienna General Hospital, Medical University of Vienna, July 18th 2017. 4. Introduction of the Medical University of Vienna and TCM University Course. Xiyuan Hospital of China Academy of Chinese Medical Sciences. Beijing China. October 27th 2017. 5. Evaluation of the effect of Chinese herbal medicine on myocardial infarction and prostate cancer. Nanjing First Hospital of Nanjing Medical University. October 31st 2017.

Shan He 1. Analysis of novel therapeutic approaches and protential diagnostic markers in prostate cancer. 12th The Young Scientist Association (YSA) PhD-Symposium. Medical University of Vienna, Vienna, Austria, June 9, 2017.

Eva Untersmayr-Elsenhuber 1. The role of gastric digestion in food allergy, ImpARAS digestion workshop, Rennes, France, April 3, 2017 2. Persönliche Erfahrungen mit Forschungsförderungen. Schrittweise Seminar, Vienna, Austria, June 6, 2017 3. Intesinal epithelial barrier function in IgE-mediated disease. Annual meeting fo the EAACI, Helsinki, Finland, June 21, 2017 4. Microbiome – implication in practice. EAACI ISMA meeting, Luxembourg, November 9, 2017 5. Neue Therapiestrategien bei Nahrungsmittelallergien. Drug targeting lecture series. Vienna, Austria, December 1, 2017

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

1.1.4. Congress organization

Division member Name: National Intern. congress, congress Function Name, date Function Name, date Erika Jensen-Jarolim Workshop for Chair AllergoOncology, London, UK, April 24, 2017, EAACI Task Force Erika Jensen-Jarolim Business meeting for Chair AllergoOncology, Helsinki, Jun 19, 2017, EAACI Task Force Erika Jensen-Jarolim Business meeting for Secretary Adjuvants in Allergen- Immunotherapy (AiAIT), Helsinki, Jun 20, 2017, EAACI Task Force Erika Jensen-Jarolim Workshop for Host AAdjuvants in Allergen- Immunotherapy (AiAIT), Vienna, Austria. Nov. 12-13, 2017, EAACI Task Force Enikö Kallay 3rd International Member of the Symposium on the Organising Calcium-sensing Committee receptor, 11-13.05.2017, Florence, Italy Enikö Kallay 20th Workshop on Member of Vitamin D, March 28-31 scientific 2017, Orlando, USA. committee Eva Untersmayr- EAACI Winter school, Organizing Elsenhuber January 26-29, 2017 committee

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

1.1.5. Hosting speakers

division member Speaker´s name Affiliation Date Franzsika Roth-Walter Ass. Prof. Cristiana - Department of Medicine, November 16, Stellato, MD, PhD Surgery and Dentistry, 2017 "Scuola Medica Salernitana", University of Salerno, Salerno, Italy - Adjunct Associate Professor, Johns Hopkins, University School of Medicine, Baltimore, MD, USA

Yan Ma Yu Zhang Shanghai University of March 17th 2017 Chinese Medicine, China Yan Ma Ping Zhang Beijing Xiyuan Hospital, December 5th China Academy of Chinese 2017 Medical Sciences, China

1.1.6. Mobility

Name Program University, Time frame Division In Ou Country t Sherienne Joint- Egyptian Ministry of July 25, 2016 – 1 X Mohammed Supervision Higher Education, July 24, 2018 Moussa Afify Program Egypt 2 years Judit Fazekas CCHD DK St John’s Institute of February 29 – June 1 X Dermatology 30, 2017 Kings´College 4 months London, UK Jelena CCHD DK St John’s Institute of Oct 5 – Nov 30, 1 X Gotovina Dermatology 2017 Kings´College 2 months London, UK Ina Herrmann Vetmeduni State University June 1, 2017 – 1 X College of Vet. June 30, 2018 Medicine 1 year Dpt. Molecular Biomedical Sciences, North Carolina Yu Zhang Teaching Shanghai University March - April 2017 1 X exchange of Chinese Medicine, China Fangqiao LYU Eurasia-Pacific Beijing Capital January 2017 1 X UNINET/ÖAD Medical University, China Ping Zhang Eurasia-Pacific Beijing Xiyuan December 2017 1 X UNINET/ÖAD Hospital, China Academy of Chinese Medical Sciences, China

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

Luca Iamartino CaSR Instituto de October 26 – 1 X Biomedicine Investigaciones December 3, 2017 Biomédicas "Alberto Sols" CSIC-UAM, Madrid, Spain

1.1.7. Activities in Advisory Boards

Name Society/Institute/Journal Function Erika Jensen-Jarolim Center for Regenerative Advisory Board Medicine and Orthopedics, Donau- Universität Krems Erika Jensen-Jarolim Austrian Society of Allergy and Delegate Clinical Immunology in World Allergy Organization Erika Jensen-Jarolim European Academy of Allergy Board member of Interest Group and Clinical Immunology for Comparative and Veterinary Allergology Erika Jensen-Jarolim European Academy of Allergy Chair of Task and Clinical Immunology Force „AllergoOncology Erika Jensen-Jarolim European Academy of Allergy Secretary in Task and Clinical Immunology Force „Adjuvants in Allergen- Immunotherapy (AiAIT)“ Erika Jensen-Jarolim European Academy of Allergy Member in Interest and Clinical Immunology group „Allergy Diagnosis“ Erika Jensen-Jarolim American Academy of Allergy, Member of Committee for Asthma and Immunology Allergen Immunotherapy (AAAAI) Erika Jensen-Jarolim American Academy of Allergy, Member of Committee for Asthma and Immunology Allergen standardization (AAAAI) Erika Jensen-Jarolim American Academy of Allergy, Member of Committee for Allergy Asthma and Immunology Diagnosis (AAAAI) Erika Jensen-Jarolim American Academy of Allergy, Member of Committee of Asthma and Immunology Eosinophilic Esophagitis (AAAAI) Franziska Roth-Walter Comparative Medicine Chemical Safety Delegate Department Franziska Roth-Walter EAACI taskforce Secretary Immunopharmacology Franziska Roth-Walter EAACI taskforces Member AllergoOncology and Adjuvants in Allergenimmunotherapy Yan Ma Consortium for Globalisation of Expert of Education Session Chinese Medicine Yan Ma World Federation of Chinese Member Medicine Yan Ma Eurasia-Pacific Uninet Member Yan Ma Austrian Society for Medical Member Anthropology Yan Ma The World Federation of Member Chinese Medicine Society Eva Untersmayr-Elsenhuber European Academy of Allergy Secretary of Basic and Clinical and Clinical Immunology Immunology Section Eva Untersmayr-Elsenhuber European Academy of Allergy Chair of Task Force „Public and Clinical Immunology Outreach” Eva Untersmayr-Elsenhuber European Academy of Allergy Member of Task Force and Clinical Immunology „AllergoOncology” 40

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

Eva Untersmayr-Elsenhuber European Academy of Allergy Member of Task Force and Clinical Immunology „ImmunoNutrition” Eva Untersmayr-Elsenhuber European Academy of Allergy Member of Task Force „MDT and Clinical Immunology working”

1.1.8. Editorial Activities

Name Journal Function Erika Jensen-Jarolim World Allergy Organization Chief in Editor Journal Erika Jensen-Jarolim Allergy, Asthma and Associate Editor Immunology Research Erika Jensen-Jarolim Journal of Biorepository Science Editorial Board for Applied Medicine, Dove Press Erika Jensen-Jarolim Wiener Med. Wochenschrift Associate Editor Erika Jensen-Jarolim Int. Archs Allergy & Immunology Associate Editor Erika Jensen-Jarolim Allergo Journal International Associate Editor Erika Jensen-Jarolim Immunology Letters Editorial Board Member Erika Jensen-Jarolim The Open Allergy Journal Editorial Board Member Erika Jesen-Jarolim Gesundheit.gv.at Expert Reviewer

1.1.9. Review Activities

Name Journals Erika Jensen-Jarolim Allergy, ALL-2017-00050, ALL-2017-00154, ALL-2017-00608 Erika Jensen-Jarolim Intern. Archives of Allergy and Immunology, IAA_201708009 J Allergy and Clin Immunology, JACI-D-17-01203, JACI-D-17- Erika Jensen-Jarolim 01592, JACI-D-17-00193 Cancer Immunology and Immunotherapy, CIIM-D-17-00105, CIIM- Erika Jensen-Jarolim D-16-00356 Erika Jensen-Jarolim Exp. Dermatology, EXD-17-0139 Erika Jensen-Jarolim WAO-Journal, WAOJ-D-17-00004 Erika Jensen-Jarolim Allergy, Asthma and Clinical Imunology, AACI-D-17-00065 Erika Jensen-Jarolim Annals of Asthma, Allergy and Immunology, ANNALS 17-10-0528 Erika Jensen-Jarolim Review Cancer Research 178802 Erika Jensen-Jarolim Clin. Exp- Allergy, CEA 2017 0368 Franzsika Roth-Walter World Allergy Organization Journal WAOJ-D-17-00023 Franzsika Roth-Walter Immunotherapy IMT-2017-0048 Franzsika Roth-Walter Molecular Nutrition and Food Research # mnfr.201700669 Franzsika Roth-Walter Oncotarget #035197 Franzsika Roth-Walter Scientific Reports SREP161967 Franzsika Roth-Walter Research in Veterinary Science RVSC_2017_454

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

Enikö Kallay DNA and Cell Biology Enikö Kallay Molecular and Cellular Endocrinology Enikö Kallay Molecular Diagnosis & Therapy Enikö Kallay Nature Review Urology Enikö Kallay International Journal of Cancer Enikö Kallay Journal Of Steroid Biochem. Mol. Biol. Enikö Kallay Scientific Reports Enikö Kallay Food and Chemical Toxicology Eva Untersmayr-Elsenhuber J Allergy Clin Immunol Eva Untersmayr-Elsenhuber Allergy Eva Untersmayr-Elsenhuber Nutrients Eva Untersmayr-Elsenhuber PLoS One Eva Untersmayr-Elsenhuber Scientific Reports Eva Untersmayr-Elsenhuber Molecular Nutrition and Food Research Eva Untersmayr-Elsenhuber WAO Journal Name Grants/Thesis/Habilitation Erika Jensen-Jarolim Review of PHD Thesis: Bleranda Zeka Review of PHD Thesis: Carlien Leyssens, Katholieke Univ. Leuven, Enikö Kallay Belgium Enikö Kallay Review of PHD Thesis: Daniela Weinmann, MUW Enikö Kallay Review of PHD Thesis: Turki Faris Alselmi, Manchester Univ. UK European Commission Horizon 2020, Amria Sklodowska Curie Enikö Kallay Actions, Individual Fellowships European Commission Horizon 2020, Amria Sklodowska Curie Enikö Kallay Actions, NCP Enikö Kallay Review Tierversuchsanträge für die Wiener Landesregierung Medizinisch-Wissenschaftlicher Fonds des Bürgermeisters der Yan Ma Bundeshauptstadt Wien (Grant Review) Eva Untersmayr-Elsenhuber FWO grant, Belgium Eva Untersmayr-Elsenhuber Wetenschappelijk Fonds Willy Gepts (WFWG), Belgium Eva Untersmayr-Elsenhuber Agreen Skills grant, France Eva Untersmayr-Elsenhuber COST action, EU Eva Untersmayr-Elsenhuber Habilitation, Technical University Darmstadt Name Expert opinion Erika Jensen-Jarolim Je-S Medical Research Council project MRC R009139/1 , UK Erika Jensen-Jarolim Core 2017 Call, Fonds de la Recherche National, Luxembourg Erika Jensen-Jarolim Swiss National Science Foundation SNSF, 310030 179165 World Allergy Organization: Expert committee for the harmonization Erika Jensen-Jarolim of COIs in „Update in DRACMA“ Municipal Dept. of Vienna, MA58: GZ-997789-2016, GZ- 997789- Erika Jensen-Jarolim 2016, GZ-340118-2017, GZ- 516079-2017, GZ-647434-2017, GZ- 780943-2017, GZ- 920093-2017

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

1.1.10. Filed and granted patents

Name Patent

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

1.1.11. Grants

Funding agency Title of project Principal investigator FWF (Austrian Comparative Allergology Erika Jensen-Jarolim Science Fund), W 1248-B13, doctoral college MCCA – Molecular, Clinical and Cellular Allergology, part I. FWF (Austrian Comparative Allergology Erika Jensen-Jarolim Science Fund), W1248-B13 doctoral college, MCCA – Molecular, Cellular, Clinical Allergy part II FWF (Austrian Cellular interactions decisive for immune Erika Jensen-Jarolim Science Fund), responses. W1205-B09 doctoral college, CCHD - Cell Communications in Health and Disease, part III FWF (Austrian Development of mimotope vaccines for Erika Jensen-Jarolim Science Fund), SFB preclinical and comparative medicine F4606-B19 studies. Horizon 2020 Calcium-Sensing Receptor (CaSR): Enikö Kallay FA648A0408 Therapeutics for Non-Communicable Diseases “ CaSR Biomedicine WWTF FA648A0407 Dietary Vitamin Da powerful weapon in Enikö Kallay the war against colorectal cancer. FWF (Austrian Ca2+ signaling in BRAF-mutant tumors: Enikö Kallay Science Fund) therapeutic resistance and drug I1662-B13 combinations. FWF (Austrian Loss of the calcium-sensing receptor in Enikö Kallay Science Fund) P colorectal tumourigenesis: a major event 29948-B28 or another collateral damage? FWF (Austrian S1P as a biomarker for food allergy. Eva Untersmayr- Science Fund), Elsenhuber APKLI284FW Institut Allergosan - Eventtag Begehbarer Darm Eva Untersmayr- AP00698OFF Elsenhuber FWF (Austrian Nahrungsmittelallergie – eine harte Nuss Eva Untersmayr- Science Fund) – zu knacken. Elsenhuber WKP39 Nordmark GmbH - Wirkungsmechanismen der Pepsin- Eva Untersmayr- AP Enzymtablette Enzynorm® f im Elsenhuber Zusammenhang mit der Nahrungsmittelallergien BMWFW/AWS - Allergieprävention durch orale Eva Untersmayr- FA648A1703 Verabreichung chemisch modifizierter Elsenhuber Proteine. EU (H2020) - 768641 AllerScreening, Point-of-care device base Eva Untersmayr- on KETs for diagnosis of food allergies. Elsenhuber Bundesministerium Evaluation of Chinese herbal medicine Yan Ma für Wissenschaft, therapy of lifestyle related diseases Forschung und Wirtschaft (BMWFW) FA648A0904

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

Medizinische Universitätslehrgang Grundlagen und Yan Ma Universität Wien Praxis der TCM LG15017010 Medizinische Universitätslehrgang Grundlagen und Yan Ma Universität Wien Praxis der TCM LG15017020 Eurasia-Pacific Ernst Mach-Stipendien, Eurasia-Pacific Yan Ma/ Fangqiao LYU Uninet/ÖAD Uninet for Postdocs. Eurasia-Pacific Ernst Mach-Stipendien, Eurasia-Pacific Yan Ma/ Ping Zhang Uninet/ÖAD Uninet for Postdocs Eurasia-Pacific Improvement of Ventricular Remodeling Yan Ma Uninet/ÖAD 2017/18 after Myocardial Infarction by Panax FA648A0906 quinquefolius Saponins and their interactions with Aspirin and Clopidogrel.

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

1.1.12. Career Developments a) Habilitations: n = 0

b) Habilitations in progress: n = 0

c) Professorships: n = 0

d) Qualification Agreement: n = 0

e) Trainings: n = 2

Franziska Roth-Walter 1. LeadingVet; S 0102, LeadingVet: Recruiting – Die richtige Person am richtigen Platz; Mag.ª Anna Hundstorfer; June 13, 2017

Isabella Pali-Schöll 1. Participation in seminar “Photo preparation for publications”, University of Veterinary Medicine, Vienna, September 27,2017

1.1.13. Teaching a) Bachelor students: n = 8

Erika Jensen-Jarolim 1. Simona Winkler, “Method development for complete extraction of beta-lactoglobulin from stable dust extract.“ März 2017 – Juni 2017 2. Manuela Czernohaus, "Impact of catechin and epicatechine on the iron-status and aryl hydrocarbon receptor activation” since January 2017 – November 2017

Eva Untersmayr-Elsenuber 2. Anna Blaas, “The impact of posttranslational modified allergens on the immune response in the animal model Mus musculus.” May 2017-ongoing 3. Carina Peischl, „Der Einfluss von Alternaria alternata auf die Zytokinproduktion und die Integrität von Caco-2 Zellen.“ Feb. 2017 – June 2017 4. Christina Fastl, “Histological Evaluation of Mouse Small Intestine and Colon Tissue after mucolytic medication.” August 2016 - April 2017 5. Jasmin Huber, “Gastric digestion and the role of protein fragments in food allergy.” February 2017-April 2017 6. Judith Pekar, “The stability of food allergens during gastrointestinal digestion.” October 2017-ongoing

Performance Report 2017 – Division 1 Comparative Immunology and Oncology b) Diploma, MDiploma and n students: n = 23

Erika Jensen-Jarolim 1. Lena Kreutzer (IMHAI), Master, "Examining the stress response of horses and humans during equine assisted therapy and subsequent regeneration of the horse" ongoing 2. Lucie Pribylova, (IMHAI), Master, „Quality of Life Assesment of blind people with and without dog“ 3. Julia Sikora, (VetMed), Diploma 4. Larissa Kawasch, „Social behaviour and stress in kune kune pigs“, 2015 – ongoing 5. Christina Pranger, MSc, „The effect of stress on allergic reactivity“; 2015 – ongoing 6. Stella Ahlers, MSc, „Immunochemical analysis of samples from stable dust an bovine urine, and characterization of their immunomodulatory potency“. 7. Alina Groschopf, MSc, „Immune modulation mediated by macrophages - IgG4 interaction in allergy and cancer.“ 8. Anton Vidovic „Implication of siderophores in allergy“ March 2016 - ongoing 9. Mario Müller „Immunological modulations by environmental molecules in vitro“, March 2016 - March 2017 10. Katharina Kienast, Master, “Impact of quercetin on lipocalins and aryl hydrocarbon receptor activation” since October 2016 – September 2017

Enikö Kallay 1. Nora Geissler, Master, “CaSR and G-protein expression in colon cancer cell lines”, 2016-2017 2. Malgorzata Cichon, Master, “The calcium toolkit in colorectal cancer cells”, 2016- 2017 3. Rebecca Grüneis, Master, “Genetic characterisation of the calcium-sensing receptor (CaSR) in colorectal cancer cells and stably transfection of a colorectal cancer cell line with CaSR”, 2016- 2017 4. Himadri Bahadur, Master, “Thapa Role of the Calcium-Sensing Receptor in inflammation”, 2017-ongoing 5. Judit Repas, Master, “Influence of vitamin D and calcium on inflammation in colon cancer cells”, 2017- ongoing

Yan Ma 1. Feder Astrid, Master, “Efficiency of Acupuncture as a Perioperative Pain Therapy after Total Knee Replacement - A prospective randomized controlled study.”, March 2013- ongoing 2. Xiaoxia Wang, Master, “The journey of compound Danshen (Salvia miltiorrhizae) dripping pills for treating angina pectoris and coronary heart diseases.” August 2013 – ongoing 3. Mao Xinjun, Master, “The clinical effect of sham acupuncture for analgesia of total knee replacement in the perioperative period.” October 2013- ongoing 4. Zheng Prokop, Master, „Die Effektivität der Akupunkturtherapie bei Tinnitus." November 2016 – ongoing

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

Eva-Untersmayr-Elsenhuber 1. Martina Klems, Diploma, “Influence of mucolytics on intestinal mucus” October 2015- November 2017 2. Eleonora Weidmann, Diploma, “Impact of mouse feed composition on the immune response in an oral food allergy model.” March 2017-ongoing 3. Klara Seppova, Master, “Evaluation of the preventive effect of gastric digestion on allergy development” October 2017 - ongoing 4. Carmen Müllauer, Master, “The use of TCM herbs, specifically “Baishao”, as active ingredients in formulations of Chinese medication for treatment of intestinal immune dysfunction” May 2016 – ongoing (TCM Universitätslehrgang)

c) PhD, MDSci, MD students: n = 17

Erika Jensen-Jarolim 1. Judit Fazekas, PhD, “Alternative concepts for immunotherapy of cancer”, 2013 - ongoing 2. Galateja Jordakieva, PhD, „Blood cell dynamics after respiratory challenge of sensitized patients“ 2012 - ongoing 3. Jelena Gotovina, PhD, “The role of macrophages in stress responses” 2013 - ongoing 4. Lukas Einhorn, PhD “Recombinant species-specific FcεRIα for molecular diagnosis and comparative study of allergic diseases in veterinary patients” 2013 - ongoing 5. Ina Herrmann, PhD „Immune mechanisms in canine allergy“ 2015 - ongoing 6. Christina Pranger, PhD “Comparing the clinical impact and molecular mechanisms of house dust mite (HDM) allergens in human versus canines“ 2017 - ongoing 7. Verena Köhler, PhD, “Biochemical Characterisation of recombinant Anti-Bet-v-1- Antibodies and cellular response mechanisms in allergy“ 2017 – ongoing 8. Sherienne Afify Since August 2016– PhD student, Co-supervision 9. Sebastian Szikora, MD Master thesis, „ Iron deficiency in allergy“ Since October 2017 10. Martin Sulzbacher, MD Master thesis, “Trace elements and allergy” since October 2017

Enikö Kallay 1. Luca Iamartino, PhD, “Evaluation of CaSR - based therapeutics in prevention of tumourigenesis and metastatic potential in colorectal cancer” 10/2016 – ongoing 2. Taha Elajnaf, PhD, “Calcium-sensing receptor-mediated signalling in colonocytes” 10/2016 – ongoing

Yan Ma 1. Shan He (01242076, N094), “Anti-inflammatory effects of the Chinese herbal medicine Sini Tang and Ginseng (Panax quinquefolius) saponins” 2013 – ongoing 2. Lene Ladanyi, MD, (n1007827, N202) “Randomized Controlled Trial of Jiawei Xiaoyao Capsule Treatment on Mild to Moderate Major Depression and Generalized Anxiety Disorder” December 2016 - ongoing 3. Svenja Krüger, MD, (N202) „TCM Kräutermedizin: „Jiawei Xiaoyao“ bei Major Depression und Angststörung (Subthemen: Essstörung und postmenopausale Depression) im Vergleich mit Psychotherapie“December 2016 – ongoing 48

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

4. Winnie Xiao, MD, (01442237, N202), October 2017 – ongoing 5. Amar Saciri, MD, (01442267, N202) “Anti-tumor activities of Gynostemma pentaphyllum and potential biomarkers in prostate cancer” November 2017 – ongoing

1.1.14. Exams a) Oral examinations: n = 11

Erika Jensen-Jarolim: Rigorosen old Medical Curriculum January 19, 2017 Weindl Christine March 6, 2017 Ebner Tamara, Tejareh Niloufar May 8, 2017 Reiter Roswitha, Koelly Nicole June 26, 2017 Ramesh Mehri, Koelly Nicole November 10, 2017 Hascha Larry, Dragusha Nexhat, Demirsoy Ismail

Eva Untersmayr-Elsenhuber: Rigorosen old Medical Curriculum October 4, 2017 Hascha Larry

b) Diploma and Thesis-Examinations: n = 13

Erika Jensen-Jarolim Master Defenses: Schindlbauer, Pranger, Groschopf, Klienspiess, PhD Defenses: Kmenta

Franziska Roth-Walter Mariona Camps I Bossacoma, PhD thesis: Influence of a cocoa-enriched diet on the intestinal immune system of sensitized rats”, July 5, 2017, Faculty of Pharmacy and Food Science, University of Barcelona, Spain

Enikö Kallay

Carlien Leyssens, 1.02.2017; “The role of the 1,25(OH)2D3 signaling cascade and its analogs in inflammatory bowel disease” Katholieke Univ. Leuven, Belgium Daniela Weinmann, 12.04.2017, “Glycobiological changes in osteoarthritic cartilage and biological effects of Galectin-1 and Galectin-3 in chondrocytes” MUW.

Turki Faris Alselmi, 12.12.2017 “Role of 1,25-Dihydroxyvitamin D3 and the Vitamin D Receptor in Coronary Artery Smooth Muscle Cell Signalling and Mineralisation”, Manchester Univ. UK

Yan Ma Kui Luan, Master Thesis: Effekt von Qigong auf chronische Schmerzen in der Komplementärmedizin - Eine Meta-Analyse. August 24th 2017

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

Eva Untersmayr-Elsenhuber Maria del Mar Rigo Adrover, PhD thesis: “Modulating activities of prebiotics and probiotics on rotavirus infections in a model of lactating rats”, January 30, 2017, Faculty of Pharmacy and Food Science, University of Barcelona, Spain Krzysztof Dudek, MD thesis: Epidemiologic characteristics of patients with chronic hepatitis C and treatment outcome with new interferon-free regimens under real-world conditions - a retrospective study, October 11, 2017, Medical University of Vienna, Vienna, Austria Christine Pranger, Master thesis: Effects of acute stress on the reliability of skin prick testing and mediator release: clinical study in healthy and allergic volunteers using the Trier social stress test September 5, 2017, VetMed Uni Vienna, Austria c) Exam supervising: n = 0

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

1.1.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2017 Jensen-Jarolim Erika 2.00 0.67 648010 Progress Report in Comparative Allergology, Oncology and Immunology Jensen-Jarolim Erika 5.00 2.50 648031 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten gem. § 13/1 lit. a StG) Jensen-Jarolim Erika 2.00 1.50 860059 TS: New Developments and comparative aspects in allergology, oncology and immunology Jensen-Jarolim Erika 2.00 0.50 860079 JC New Developments and comparative aspects in allergology, oncology and immunology Jensen-Jarolim Erika 2.00 0.07 860220 Basisvorlesung Immunologie Jensen-Jarolim Erika 2.00 0.13 861007 MCCA Journal Club Kallay Enikö 1.00 0.33 850021 Creative and critical Journal Club Kallay Enikö 2.00 1.50 860059 TS: New Developments and comparative aspects in allergology, oncology and immunology Kallay Enikö 2.00 0.23 860600 Basic Seminar Malignant Diseases II SS17 Kallay Enikö 2.00 0.67 648010 Progress Report in Comparative Allergology, Oncology and Immunology Ma Yan 2.00 1.50 860059 TS: New Developments and comparative aspects in allergology, oncology and immunology Ma Yan 4.00 0.75 808004 SSM 3-Projektstudie (Wahlpflichtteil) Ma Yan 2.00 2.00 648001 Journal Club of Molecular Research in Traditional Chinese Medicine Science Pali-Schöll Isabella 2.00 0.25 860079 JC New Developments and comparative aspects in allergology, oncology and immunology Pfanzagl Beatrix 2.27 3.55 802001 BL 4 - Funktionssysteme und biologische Regulation Roth-Walter Franziska 2.00 0.25 860079 JC New Developments and comparative aspects in allergology, oncology and immunology Untersmayr- Elsenhuber Eva 5.00 2.50 648031 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten gem. § 13/1 lit. a StG) Untersmayr- Elsenhuber Eva 2.00 1.50 860059 TS: New Developments and comparative aspects in allergology, oncology and immunology Untersmayr- Elsenhuber Eva 2.00 0.66 648010 Progress Report in Comparative Allergology, Oncology and Immunology Sum 21.06

WS 2017/18 Jensen-Jarolim Erika 2.00 0.07 562019 BVo: Immunologie Jensen-Jarolim Erika 5.00 2.50 648013 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten gem. § 13/1 lit. a StG) Jensen-Jarolim Erika 2.00 0.67 648802 Progress Report in Comparative Allergology, Oncology and Immunology Jensen-Jarolim Erika 2.00 0.10 860060 JC New Developments and comparative aspects in allergology, oncology and immunology Jensen-Jarolim Erika 2.00 0.50 860061 TS: New Developments and comparative aspects in allergology, oncology and immunology Jensen-Jarolim Erika 1.00 0.13 861007 MCCA Lecture, Thesis Seminar and Basic Course Series on Animal Models

Performance Report 2017 – Division 1 Comparative Immunology and Oncology

Kallay Enikö 5.80 0.27 803002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Kallay Enikö 5.00 5.00 514051 Wachstumsregulation humaner Tumorzellen - (Wahlfachausbildung gem. § 13 StG) Kallay Enikö 1.00 0.33 850028 Creative and critical Journal Club Kallay Enikö 2.00 0.50 860061 TS: New Developments and comparative aspects in allergology, oncology and immunology Kallay Enikö 2.00 0.20 860966 Basisseminar: Zelluläre Signaltransduktion - WS 2016 Kallay Enikö 2.00 0.67 648802 Progress Report in Comparative Allergology, Oncology and Immunology Ma Yan 2.00 1.50 648010 Journal Club of Molecular Research in Traditional Chinese Medicine Science Ma Yan 4.00 0.50 808008 SSM 3-Projektstudie (Wahlpflichtteil) Ma Yan 2.00 0.50 860061 TS: New Developments and comparative aspects in allergology, oncology and immunology Pfanzagl Beatrix 2.00 2.00 803009 Problemorientiertes Lernen - 3. Semester Untersmayr- Immunpathologische Laboratoriumstechnik - mit Demonstrationen (Wahlfachausbildung gem. Elsenhuber Eva 3.00 3.00 648011 § 13/1 lit. a StG) Untersmayr- Elsenhuber Eva 5.00 2.50 648013 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten gem. § 13/1 lit. a StG) Untersmayr- Elsenhuber Eva 2.00 0.50 860061 TS: New Developments and comparative aspects in allergology, oncology and immunology Sum 21.44 Total sum SS+WS 42.50

LV Yan Ma SS 2017 Ma Yan 2.00 648.001 Journal Club of Molecular Research in Traditional Chinese Medicine Science Ma Yan 1.50 891.025 M4 - Klinische Observation in China oder in Österreich Ma Yan 0.27 891.111 M4 - Orthopädie in der TCM Ma Yan 0.54 891.143 M4 - Einführung in die medizinische chinesische Fachsprache und Kultur (4) Ma Yan 0.54 891.142 M4 - Chirurgie in der TCM Ma Yan 1.34 891.144 M3 - Innere Medizin in der TCM WS 2017/18 Ma Yan 0.60 891.050 M5 - Tuina und Massage Ma Yan 0.80 891.052 M5 - Einführung in die Medizinische chinesische Fachsprache und Kultur (5) Ma Yan 2.00 891.051 M5 - Klinische Observation in China oder in Österreich

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

1.2. Division for Cellular and Molecular Pathophysiology Head: Peter Pietschmann, MD, Professor

1. Publications5 IF Number Top/Std/Subst Isabella Ellinger 11.419 5 1/3/0 Diana Merchtcheriakova 20.553 14.4 6/2/2 Peter Pietschmann 14.321 11 3/5/0 Division-Sum 33.696 25.4 8/9/2 Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2

2. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Isabella Ellinger 2 3 3 Diana Mechtcheriakova 1 2 2 Peter Pietschmann 4 8 5 Sum 7 13 10

3. Teaching SS* WS* total W+S Exams Föger-Samwald Ursula 0.00 3.10 3.10 0 Isabella Ellinger 4.18 10.34 14.52 0 Renate Fuchs 4.00 4.00 8.00 0 Diana Mechtcheriakova 0.25 0.91 1.16 0 Peter Pietschmann 3.99 4.50 8.49 0 Theresia Thalhammer 0.05 0.12 0.17 0 Sum 12.47 22.97 35.44 0

5 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications. 53

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

1.2.1. Publications a) Peer-reviewed original articles: n = 16

Nr. Article IF Class pro-rata IF 1. Kamper, M., F. Mittermayer, R. Cabuk, K. Gelles, I. Ellinger 3.112 Std 3.112 and M. Hermann. Estrogen-enhanced apical and basolateral secretion of apolipoprotein B-100 by polarized trophoblast- derived BeWo cells. Biochimie 2017; 138:116-123

2. Klameth, L., B. Rath, M. Hochmaier, D. Moser, M. Redl, F. 4.259 Top 4.259 Mungenast, K. Gelles, E. Ulsperger, R. Zeillinger, and G. Hamilton. Small cell lung cancer: model of circulating tumor cell tumorsperes in chemoresistance. Sci Rep 2017; 7:5337

3. Klameth, L., B. Rath, and G. Hamilton. In vitro cytotoxic 2.916 Std 0.583 activities of the oral platinum (IV) prodrug oxoplatin and HSP90 inhibitor ganetespib against a panel of gastric cancer cell lines. J Cancer 2017; 8:1733-1743

4 Ganjian, H, C. Zietz, D. Mechtcheriakova, D. Blaas, and R. 3.465 Std 3.465 Fuchs. ICAM-1 binding rhinoviruses enter HeLa Cells via multiple pathways and travel to distinct intracellular compartments for uncoating. Viruses 2017; 9:68

5. Jurkin, J., C. Krump, R. Köffel, C. Fieber, C. Schuster, P.M. 13.081 Top 2.616 Brunner, I. Borek, Eisenwort G., C. Lim, J. Mages, R. Lang, W. Bauer, D. Mechcheriakova, A. Meshcheryakova, A. Elbe-Bürger, G. Stingl, and H. Strobl. Human skin dendritic cell fate is differentially regulated by the monocyte identity factor Kruppel-like factor 4 during steady state and inflammation. J Allerg Clin Immunol 2017; 139:1873-1884

6. Pfanzagl, B., D. Mechtcheriakova, A. Meshcheraykova, 4.259 Top 0.852 S.W. Aberle, R. Pfragner, and E. Jensen-Jarolim. Activation of the ileal neuroendocrine tumor cell line P-STS by acetylcholine is amplified by histamine: role of H3R and H4R. Sci Rep 2017; 7:1313

7. Kovarik, J.J., E. Kernbauer, M.A. Hölzl, J. Hofer, G.A. 2.806 Std 0.561 Gualdoni, K.G. Schmetterer, F. Mifari, Y. Sobanov, A. Meshcheryakova, D. Mechcheriakova, N. Witzeneder, G. Greiner, A. Ohradanova-Repic, P. Waidhofer-Söllner, M.D. Säemann, T. Decker, and G.J. Zlabinger. Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis. PLoS One 2017; 12:e0180900

8. Wagner, F., G. Dvorak, S. Nemec, P. Pietschmann, M. Figl, 2.011 Std 0.402 and R. Seemann. A principal components analysis: how pneumatization and edentulism contribute to maxillary atrophy. Oral Dis 2017; 23:55-61

9. Muschitz, C., R. Kocijan, A. Baierl, R. Dormann, X. 3.591 Std 0.718 Feichtinger, J. Haschka, M. Szivak, G.K. Muschitz, J. Schanda, P. Pietschmann, H. Resch and H.P. Dimai.

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

Preceding and subsequent high-and low-trauma fracture patterns – a 13-year epidemiological study in females and males in Austria. Osteoporos Int 2017; 28:1609-1618

10. Sanchez-Gonzalez, C., L. Moreno, C. Lopez-Chaves, E. 3.975 Std 0.795 Nebot, P. Pietschmann, A. Rodriguez-Nogales, J. Galvez, M. Montes-Bayon, A. Sanz-Medel, and J. Llopis. Effects of vanadium on calcium homeostasis, osteopontin mRNA expression, and bone microarchitecture in diabetic rats. Metallomics 2017; 22:258-267

11. Wagner, F., G. Dvorak, S. Nemec, P. Pietschmann, H. 4.259 Top 0.852 Traxler, K. Schicho, and R. Seemann. Morphometric analysis of sinus depth in the posterior maxilla and proposal of a novel classification. Sci Rep 2017; 7:45397

12. Nebot, E., A. Virginia, P. Pietschmann, D. Camiletti-Moirón, 2.084 Std 2.084 G. Kapravelou, R.G. Erben, R. Martinez, C. Sánchez- González, J.M. Porres, J. Llopis, M. López-Jurado, and P. Aranda. Effects of hypertrophy exercise in bone turnover markers and structure in growing male rats. Int J Sports Med 2017; 38:418-425

13. Dovjak, P., G. Heinze, A. Rainer, W. Sipos, and P. 3.340 Std 3.340 Pietschmann. Serum levels of dickkopf-1 are a potential negative biomarker of survival in geriatric patients. Exp.Gerontol 2017; 96:104-109

14. Muschitz, G.K., E. Schwabegger, A. Fochtmann, A. Baierl, R. 6.284 Top 1.257 Kocijan, J. Haschka, W. Gruther, J.E. Schanda, H. Resch, T. Rath, P. Pietschmann, and C. Muschitz. Long-term effects of severe burn injury on bone turnover and microarchitecture. J Bone Miner Res 2017; 32:2381-2393.

15. Mungenast, F., S. Aust, I. Vergote, A. Vanderstichele, J. 1.390 Subst 1.390 Sehouli, E.. Braicu, S. Mahner, D.C. Castillo-Tong, R. Zeillinger, and T. Thalhammer. Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer. Oncol Lett 2017; 13:4047-4054

16. Maier-Salamon, A., S.A. Elgendy, B. Meyer, M. Vossen, T. 0.927 Subst 0.185 Thalhammer, and W. Jäger. Pharmacokinetics of flucloxacillin and its metabolites in patients with renal failure: Impact on liver toxicity. Int J Clin Pharmacol Ther 2017; 55:701-711 sum 61.759 26.471

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology b) Invited Articles & Reviews with IF: n = 3

Nr. Article IF Class pro-rata IF 1. Meshcheryakova, A., D. Mechtcheriakova, and P. 4.873 Top 4.873 Pietschmann. Sphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potential. Expert Opin Ther Targets 2017;21:725-737

2. Jensen-Jarolim, E., Bax H.J., R. Bianchini, M. Capron, C. 7.361 Top 1.472 Corrigan, M. Castells, D. Dombrowicz, T.R. Daniels-Wells, J. Fazekas, E. Fiebiger, S. Gatault, H.J. Gould, J. Janda, D.H. Josephs, P. Kragiannis, F. Levi-Schaffer, A. Meshcheryakova, D. Mechtcheriakova, Y. Mekori, F. Mungenast, E.A. Nigro, M.L. Penichet, F.Redegeld, E. Untersmayr, L. Vangelista, and S.N. Karagiannis. AllergoOncology – the impact of allergy in oncology: EAACI position paper. Allergy 2017; 72:866-887

3. Rižner, T.L.,T. Thalhammer, and C. Özvegy-Laczka. The 4.400 Top 0.880 importance of steroid uptake and intracrine action in endometrial and ovarian cancers. Front Pharmacol 2017; 8: 346. sum 16.634 7.225

c) Invited Articles & Reviews without IF: n = 3

Mahbod, A., R. Ecker, I. Ellinger. Skin lesion classification using hybrid deep neural networks. https://arxiv.org/abs/1702.08434

Nebot Valenzela, E., and P. Pietschmann. Epidemiology and pathology of Paget’s disease of bone – a review. Wien Med Wochenschr 2017; 167:2-8

Pietschmann, P. Editorial Paget’s disease of bone. Wien Med Wochenschr 2017; 167:1

d) Book contributions: n = 3

Sipos W, Föger-Samwald U, Pietschmann P. Comparing two major bone pathologies in humans and companion animals: osteoporosis and hyperparathyroidism. In: Jensen-Jarolim E (ed). Comparative Medicine – Disorders linking humans with their animals. Springer International Publishing 2017, pp. 87-96

Kerschan-Schindl K., Föger-Samwald U., P. Pietschmann. Bone turnover markers. In: Pietschmann P (ed) Principles of Bone and Joint Research (Learning Materials in Biosciences), Springer International Publishing Switzerland 2017, pp. 55-64.

Kerschan Schindl K, Föger-Samwald U., P. Pietschmann. Pathophysiology of bone fragility. In: Pietschmann P (ed) Principles of Bone and Joint Research (Learning Materials in Biosciences), Springer International Publishing Switzerland 2017, pp. 83-97.

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

e) Abstracts, printed in periodicals: n = 2

1. Muschitz, G., E. Schwabegger, A. Baierl, A. Fochtmann-Frana, R. Kocijan, J.Haschka, W. Gruther, J. Schanda, H. Resch, T. Rath, P. Pietschmann, C. Muschitz. Long-term effects of severe burn injury on bone turnover and microarchitecture. J Bone Miner Res 2017; 32:S264 2. Muschitz, C., R. Kocijan, A. Baierl, R. Dormann, X. Feichtinger, J. Haschka, G. Muschitz, J. Schanda, P. Pietschmann, H. Resch, H.P. Dimai. Preceding and subsequent high- and low-trauma fracture patterns – A 13-year epidemiological study in females and males in Austria. J Bone Miner Res 2017; 32:S 154

f) Abstracts, in congress proceedings or abstract books: n = 27

1. Palladino, C., T. Kalic, E. Waltl, V. Niederberger, T. Eiwegger, I. Ellinger, O. Palomares, H. Breiteneder. The effect of peanut allergens Ara h1 and Ara h2 and lipids on airway epithelial cells.(poster presentation) AAAAI Annual Meeting 2017 (American Academy of Allergy, Asthma & Immunology), Atlanta, USA, 3.3. – 6.3.2017

2. Föger-Samwald, U., M. Salzmann, C. Pleyer, K. Wahl-Figlash, P. Pietschmann. Skeletal heterogeneity in C57BL/6J mice. (poster prestentation) ECTS 2017 – 44th Eruopean Calcified Tissue Society Congress, Salzburg, Austria, 13.5. – 16.5.2017

3. Muschitz, C., R. Kocijan, J. Haschka, H. Resch, P. Pietschmann, H.P. Dimai. Preceding and subsequent high- and low-trauma fracture patterns – a 13-year epidemiological study in females and males in Austria. (poster prestentation) ECTS 2017 – 44th Eruopean Calcified Tissue Society Congress, Salzburg, Austria, 13.5. – 16.5.2017

4. Hackl, M., U. Föger-Samwald, S. Skalicky, A. Baierl, O. Nägele, E. Boschitz, P. Pietschmann, J. Grillari. Analysis of osteomirs in a cohort of postmenopausal women reveals high association to fracture-risk but not bone mineral density. (poster prestentation) ECTS 2017 – 44th Eruopean Calcified Tissue Society Congress, Salzburg, Austria, 13.5. – 16.5.2017

5. Nebot Valenzuela, E., P. Heimel, J. Patsch, M. Dockner, G.W. Weber, E. Winter, M. Teschler-Nicola, M. Pretterklieber, P. Pietschmann. Bone microstructure in historic bone samples with Paget’s Disease. (poster prestentation) ECTS 2017 – 44th Eruopean Calcified Tissue Society Congress, Salzburg, Austria, 13.5. – 16.5.2017

6. Palladino, C., T. Kalic, E. Waltl, V. Niederberger, T. Eiwegger, I. Ellinger, O. Palomares, H. Breiteneder. Peanut allergens Ara h1 and Ara h2 and peanut lipids impact on barrier function of human airway epithelial cells.(poster presentation) 13th YSA PhD-Symposium, Medical University of Vienna, Austria, 8.6. – 9.6.2017

7. Kalic, T., I. Ellinger, C. Radauer, B. Linhart, C. Palladino, E. Waltl, V. Niederberger, C. Hafner, H. Breiteneder. Interaction of natural and mutant fish paralbumins and fish- derived food matrix with bronchial epithelial cells. .(poster presentation) 13th YSA PhD-Symposium, Medical University of Vienna, Austria, 8.6. – 9.6.2017

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

8. Mahbod, A., M. Olesen, F. Hannan, K. Gelles, R. Ecker, I. Ellinger. Deep Convolutional Neural Networks for Parathyroid Gland Classification in HE-Stained Images. (poster presentation) 13th YSA PhD-Symposium, Medical University of Vienna, Austria, 8.6. – 9.6.2017

9. Ganjian, H., C. Zietz, D. Mechtcheriakova, D. Blaas, R. Fuchs. ICAM-1 binding human rhinoviruses enter HeLa cells via multiple pathways. (poster presentation) 13th YSA PhD-Symposium, Medical University of Vienna, Austria, 8.6. – 9.6.2017

10. Mungenast, F., A. Meshcheryakova, A. Beer, M. Salzmann, D. Tamandl, M. Bergmann, P. Pietschmann, O. Koperek, P. Birner, D. Mechtcheriakova. Understanding the heterogeneity of B-cell subsets: from dissecting tumor complexity to prognostic modeling. (poster presentation)

13th YSA PhD-Symposium, Medical University of Vienna, Austria, 8.6. – 9.6.2017 11. Nebot, E., P. Heimel, M. Dockner, J. Patsch, G.W. Weber, E. Winter, S. Tangl, M. Pretterklieber, M. Teschler-Nicola, P. Pietschmann. Micro-structural features of Paget’s disease of bone at cortical and trabecular sites. (poster presentation) 13th YSA PhD-Symposium, Medical University of Vienna, Austria, 8.6. – 9.6.2017

12. Granitzer, S., E. Straka, I. Ellinger, H. Zeisler, H. Salzer, M. Hengstschläger, C. Gundacker. Toxicogenetics of mercury in the human placenta: Preliminary data on relationships between genotype and phenotype in healthy and diseased placenta. (poster presentation) 13th International Conference on Mercury as a Global Polluntant - ICMGP 2017, Providence, Rhode Island, USA, 16.7. – 21.7.2017

13. Flicker, S., I. Ellinger, E. Waltl, K. Blatt, V. Niederberger, P. Valent, R. Valenta. Antibody conjugates bi-specific for ICAM1 and allergens prevent epithelial penetration of allergens and rhinovirus infection. (poster presentation) 47th Annual Meeting of the German Society for Immunology, Erlangen, Germany, 12.9. – 15.9.2017

14. Mahbod, A., M. Olesen, F. Hannan, K. Gelles, R. Thakker, R. Ecker, I. Ellinger. Deep convolutional neural networks for parathyroid gland detection in H&E-stained microscopic images.(posterpresentation) 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria, 19.9.2017

15. Palladino, C., T. Kalic, E. Waltl, V. Niederberger, T. Eiwegger, I. Ellinger, O. Palomares, H. Breiteneder. Peanut allergens Ara h1 and Ara h2 and peanut lipids impact on barrier function of human airway epithelial cells.(poster presentation) 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria, 19.9.2017

16. Podgorzak, V., K. Gelles, L. Walch, S. Török, I. Erblich, R. Widhalm, R. Cabuk, I. Ellinger, C. Gundacker. Characterization of human placental iron metabolism – towards an improved therapy of preterm iron deficiency. .(poster presentation) 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria, 19.9.2017

17. Flicker, S., I. Ellinger, E. Waltl, K. Blatt, C. Cabauatan, K. Niespodziana, V. Niederberger, P. Valent, R. Valenta. Antibody conjugates bi-specific for ICAM1 and allergens prevent epithelial penetration of allergens and rhinovirus infections. (poster presentation)

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria, 19.9.2017

18. Gelles, K., W. Seebacher, C. Jungwirth, C. Gundacker, C. Husano, R. Ecker, G. Dorffner, I. Ellinger. Quantification of amino acid transporter expression in the human placenta – a pilot study comparing automated quantitative immunofluorescence microscopy with quantitative immunoblotting. (poster presentation) 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria, 19.9.2017

19. Meshcheryakova, A., M. Svoboda, F. Mungenast, M. Salzmann, M. Jaritz, D. Pils, Castillo-Tong DC, members of OVCAD Consortium, P. Birner, P. Zimmermann, G. Heinze, R. Zeillinger, D. Mechtcheriakova. Specific interplay between sphingolipid and immue systems in ovarian cancer: a systems medicine-based study.(poster presentation) 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria, 19.9.2017

20. Mungenast, F., A. Meshcheryakova, A. Beer, M. Salzmann, J. Salkanovic, D. Tamandl, M. Bergmann, T. Grünberger, P. Pietschmann, P. Birner, Koperek O, D. Mechcheriakova. Ectopic lymphoid structures in cancer tissues: dissecting complexity and functionality. (poster presentation) 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria, 19.9.2017

21. Föger-Samwald, U., C. Meyer, F. Mungenast, K. Wahl-Figlash, P. Pietschmann. The effect of age on B cell subsets in C57/BL6 mice. (poster presentation) 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria, 19.9.2017

22. Leitner, M., U. Föger-Samwald, R. Martinez, G. Kapravelou, C. López-Chaves, M. Galisteo, P. Aranda, M. López-Jurado, J.M. Porres, P. Pietschmann, E. Nebot. Divergent effects of obesity on bone microarchitecture in Sprague-dawley rats. (posterpresentation) 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria, 19.9.2017

23. Kalic, T., I. Ellinger, C. Radauer, B. Linhart, V. Mayr, E. Waltl, C. Palladino, V. Niederberger, C. Hafner, H. Breiteneder. Interaction of natural and mutated fish parvalbumins and fish-derived food matrix with bronchial epithelial cells. (poster presentation) Joint Symposium of the two PhD programs “Inflammation and Immunity (IAI)” and “Molecular, Cellular and Clinical Allergology (MCCA)”, Medical University of Vienna, Austria, 25.9. – 27.9.2017

24. Flicker S., Ellinger I., Waltl E., Blatt K.,Cabauatan C., Niespondziana K., Niderberger V., Valent P., Valenta R. Antibody conjugates bi-specific for ICAM1 and allergens prevent epithelial penetration of allergens and rhinovirus. (poster presentation) ÖGAI (Österreichische Gesellschaft für Allergologie & Immunologie) Annual Meeting 2017, Vienna, Austria, 23.11. – 25.11.2017. Abstract book Session 2.2, p. 4.

25. Pietschmann P., C. Mayer, Mungenast F., Wahl-Figlash K. Föger-Samwald U. The effect of age on B cell subsets in C57/BL6 mice. (poster presentation) ÖGAI (Österreichische Gesellschaft für Allergologie & Immunologie) Annual Meeting 2017, Vienna, Austria, 23.11. – 25.11.2017. Abstract book P03.05, p. 25

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

26. Uranowska K., Kalic T., Karapand K., Ellinger I., Breiteneder H., Schaider H., Hafner C. Expression of chonroitin sulfate proteoglycan 4 (CSPG4) in BRAF-mutant induced drug-tolerant melanoma cells (poster presentation). ÖGAI (Österreichische Gesellschaft für Allergologie & Immunologie) Annual Meeting 2017, Vienna, Austria, 23.11. – 25.11.2017. Abstract book P05.06, p. 36

27. Mungenast F., Meshcheryakova A., Beer A., Salzmann M., Salkanovic J., Tamandl D., Bergmann M., Grünberger T., Pietschmann P., Birner P., Koperek O., Mechtcheriakova D. Ectopic lymphoid structures in cancer tissues: dissecting complexity and functionality. (poster presentation). ÖGAI (Österreichische Gesellschaft für Allergologie & Immunologie) Annual Meeting 2017, Vienna, Austria, 23.11. – 25.11.2017. Abstract book P05.09, p. 37

g) Teaching Scripts and Books: n = 1

Pietschmann P. (Ed). Principles of Bone and Joint Research. Springer International Publishing Switzerland 2017

h) Articles in Medical Journals: n = 0

i) Public activity: n = 5

Isabella Ellinger:

1. Isabella Ellinger, Ursula Föger-Samwald, Felicitas Mungenast, Katharina Gelles, Katharina Wahl-Figlash (2017-07-20): „Was tut Daniel Düsentrieb? So werkt ein Forscher“. Workshop Kinderuni Wien/Medizinische Universität Wien. AKH, Wien. https://kinderuni-anmeldung.at/event.php?event_id=1489

2. Isabella Ellinger, Adolf Ellinger (2017-07-18): „Cell City – Was geht ab in der Zelle“. Vorlesung Kinderuni Wien/. Medizinische Universität Wien. AKH, Wien. https://kinderuni-anmeldung.at/event.php?event_id=1487

3. Isabella Ellinger (2017-06-22): “How to become a Cell Biologist” and “Developmental origin of Diseases”. Schulbesuch als Young Science Botschafterin. Gymnasium G19, Gymnasiumstraße 83, 1190 Wien.

4. Isabella Ellinger, Ursula Föger-Samwald (2016-03-01): „Studium – Diplomarbeit – Praktikum an der Medizinischen Universität Wien“ Informationen zu Österreichs größter medizinischer Ausbildungsstätte. Firmenmesse der HBLVA für chemische Industrie, Rosensteingasse, 1170 Wien http://hblva17.ac.at/sites/default/files/upload/dateien/event/veranstaltung/2017/ver- 1/Firmenmesse2017_20012017_Vs2.pdf

Peter Pietschmann:

5. „Osteoporose“. Veranstaltung „Gesund im AKH“, Wien MUW, 18.10.2017

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

1.2.2. Research Awards: n = 2

Anastasia Meshcheryakova: Prize for the Best Presentation: “Specific interplay between sphingolipid and immunesystems in ovarian cancer: a systems medicine-based study”, 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, November 19th, 2017

Felicitas Mungenast: Poster price: “Ectopic lymphoid structures in cancer tissues: dissecting complexity and functionality”, Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), Vienna, November 23-25, 2017

1.2.3. Invited lectures: n = 15

Isabella Ellinger:

1. “Modeling variability in quantitative immunofluorescence microscopy (qIFM)”, Univ. Klinik für Krankenhaushygiene und Infektionskontrolle, Wien, 3.2.2017

2. “Characterization of iron transport in the human placenta”, Impulse-Seminar (IPA), Wien, 14.7.2017

Ursula Föger-Samwald:

3. “Präsentation der MUW (IPA)”, HBLVA Rosensteingasse, Wien, 1.3.2017

Amirreza Mahbod:

4. “Deep convolutional neural networks for parathyroid gland detection in H & E – stained microscopic images”, CaSR Biomedicine Midterm-Meeting, Manchester, September 2017

Diana Mechtcheriakova:

5. "Distinctive interrelations between the sphingolipid and immune systems in cancer: a systems biology-based study." The 4th Retreat of the Immunology Research Cluster, Medical University of Vienna, Wien, 29.1.2017

Peter Pietschmann:

6. „Update Osteoporose.“ 4. Interdisziplinäre Tagung „Mann und Gesundheit“, Universitätszahnklinik Wien, 18.3.2017

7. „Pathophysiologie der Osteoporose.“ Osteologie 2017, Erlangen, Deutschland, 23.3.2017

8. „Alterstraumatologie“ … aus der Sicht des Osteologen, Osteologie 2017, Erlangen, Deutschland, 24.3.2017

9. „Festvortrag 20 Jahre Osteoimmunologie.“ Osteoporoseforum – Osteologie im Wandel der Zeit, St. Wolfgang, 20.4.2017

10. „Metabolisches Syndrom, Mechanostat und Knochen.“ Osteoporoseforum – Osteologie im Wandel der Zeit, St. Wolfgang, 21.4.2017

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

11. “Biologia y Fisiopathologia del hueso.” Universidad de Granada, Facultad de Farmacia, Granada, Spain, 27.4.2017

12. „Osteoporose des Mannes.“ 43. Gemeinsame Tagung der Österreichischen Gesellschaft für Urologie und Andrologie und der Bayerischen Urologenvereinigung., Wien, 20.5.2017

13. “Osteoimmunology.” 7. International Scientific and Educational Symposium of Bioregenerative Medicine inSlovakia, Bratislava, 21.9.2017 14. „Von der Pathophysiologie zur Therapie der Osteoporose.“ 4. Fachtag Medikation im Alter, Wien, 6.10.2017

15. „Differentialdiagnose der osteologischen Erkrankungen.“ Management der Osteoporose, Wien, 10.11.2017

1.2.4 Congress organization

Division member National congress Intern. congress, Name: Name, date Function Name, date Function Peter Pietschmann Osteologie 2017, Scientific Board Erlangen, Germany, Member 23.3.-25.3.2017

1.2.5. Hosting speakers

division member Speaker´s name Affiliation Date Peter Pietschmann Georg Schett, MD Friedrich-Alexander University 12/10/2017 Erlangen-Nuremberg, Department of Internal Medicine 3 – Rheumatology and Immunology, Erlangen, Germany Peter Pietschmann Claudia Gundacker, Institute of Medical Genetics, 14/07/2017 Assoc.Prof.Dr Medical Univeristy of Vienna Diana Dr. Rupert Ecker Tissue Gnostics, Vienna 16/03/ 2017 and Mechtcheriakova 17/03/2017 Diana Dr. Eric Thompsen Life Sciences Solutions, Thermo 08/05/2017 Mechtcherikova Fisher Scientific Diana Robert Nica Tissue Gnostics, Vienna 16/05/2017 Mechtcheriakova Isabella Ellinger Mag. Christine FH Campus Vienna- Biomedical 15/12/2017 Schnabl Anlaytics

1.2.6. Mobility

Name Program University, Time frame Division In Out country Elena Nebot Research Fellowship University of 10.9.2015- PP X Valenzuela, PhD Granada, Spain 10.9.2017 Waranya ASEA uninet Mahasarakham 1.5.2017 - IE X Chatuphonrasert, University, Faculty 31.5.2017 Dr. of Medicine, Thailand 62

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

1.2.7. Activities in Advisory Boards

Name Society/Institute/Journal Function Peter Pietschmann Habilitationskommission Ersatz-Mitglied der Kommission “konservativ” (Interne, Pädiatrie, Dermatologie, Radiologie) Peter Pietschmann European Calcified Tissue Member of the Grants & Award Society (ECTS) Committee

1.2.8. Editorial Activities

Name Journal Function Isabella Ellinger Wiener Medizinische Guest Editor Wochenschrift Peter Pietschmann Wiener Medizinische Managing Editor Wochenschrift Peter Pietschmann Gerontology Editorial Board Member Peter Pietschmann Zeitschrift für Gerontologie und Editorial Board Member Geriatrie Peter Pietschmann Journal für Mineralstoffwechsel Editorial Board Member Peter Pietschmann Hormone and Metabolic Editorial Board Member Research

1.2.9. Review Activities

Name Grants/Thesis/Habilitation Peter Pietschmann Deutsche Forschungsgemeinschaft Peter Pietschmann Habilitationsschrift Medizinische Universität Wien Peter Pietschmann Berufstitel „Universitätsprofessor“ Medizinische Universität Wien Peter Pietschmann 4 PhD Thesis: Medizinische Universität Wien Peter Pietschmann OeAD Antrag für Ernst Mach Stipendium Isabella Ellinger 1 PhD Thesis Medizinische Universität Wien

1.2.10. Filed and granted patents

Name Patent Isabella Ellinger Antibody Construct Patent No. 15154521.7-1412

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

1.2.11. Grants

Funding agency Title of project Principal investigator Forschungsförderungsge Fe-Transport Plazenta (Talente- Isabella Ellinger sellschaft (FFG) Praktika für Schülerinnen und Schüler Nr. 861111 2017) FA648A1018 Life science 2015 Mercury toxicokinetics in human Cooperation partner: Isabella (LS15_014) placenta: making the bridge between Ellinger genotype and phenotype in healthy and diseased placentas Project leaders: Univ.Prof. Hans Salzer (Landesklinikum Tulln, Austria) and Ass.Prof.Dr. Claudia Gundacker (Institute of Med. Genetics, Medical University of Vienna) Felix Bronner Local gene expression in bone Ursula Föger-Samwald Dissertations-stipendium samples from eldery women with AP00604OFF osteoporotic hip fractures. Jubiläumsfonds der B-Lymphozyten-assoziierte Diana Mechtcheriakova Österreichischen immunoloigsche Kontrollpunkte am Nationalbank Tumorort AP17278ONB Springer Verlag GmbH Unterstützung er Errichtung und Peter Pietschmann AP00243OFF Betreibung eines Editorial Office für die Wiener Medizinische Wochenschrift und der Publikationstätigkeit der Arbeitsgruppe Knochen-, Gender- und Altersforschung Fresenius Kabi Austria Automated Cell Detection in Peter Pietschmann GmbH Osteoimmunology. FA 648A0610 Amgen GmbH Skeletal heterogeneity in C57BL/6J Peter Pietschmann UE64801009 mice Forschungsförderungsge Knochenforschung Peter Pietschmann sellschaft (FFG) (Talente Praktika für Schülerinnen und Nr. 860899 Schüler 2016) FA648A0615 FWF – Der Effects of binge alcohol drinking during Peter Pietschmann Wissenschaftsfonds youth on bone – a pilot study APP28827FW Medizinisch- Development of peak bone mass and Peter Pietschmann Wissenschaftlicher Fonds muscle mass in inbred mouse strains: des Bürgermeisters der a pilot study Bundeshauptstadt Wien Nr. 15159 AP15159BGM Österreichische The senescence accelerated mouse Peter Pietschmann Gesellschaft für Knochen (SAMP6) as a model of und Mineralstoffwechsel osteoimmunology: a pilot study ÖGKM Projektpreis 2015 AP00725OFF

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

1.2.12. Career Developments a) Habilitations: n = 0

b) Habilitations in progress: n = 0

c) Professorships: n =0

1.2.13. Teaching a) Bachelor students: n = 7

Peter Pietschmann:

Despabiladeras Monalyn: BSc Biomedizinische Analytik. Histomorphometrische Quantifizierung von Osteozyten in Mausmodellen der altersassoziierten Osteoporose. (02/2017 – 06/2017) FH Campus Vienna

Kellner Jennifer: BSc Biomedizinische Analytik. Mausmodelle zur Erforschung der Peak Bone Mass. (10/2017 – in progress) FH Campus Vienna

Mayer Corinna: BSc Biomedizinische Analytik. Quantitativer Nachweis von B Zellen bei jungen Kontrollmäusen und alten CD57BL6J, SAR, SAMP und OF1 Mäusen in Femur und Milz. (02/2017 – 06/2017) FH Campus Vienna

Rieschl Linda: BSc Biomedizinische Analytik. Sklerostin-Expression auf Proteinebene bei Nagetieren. (10/2017 – in progress) FH Campus Vienna

Diana Mechtcheriakova:

Salkanovic Jasko: BSc Molekulare Biotechnologie. Microscopy-based qualitative and quantitative anayses of patient-specific immunological imprint in solid tumors. (01/2017 – 05/2017) FH Campus Vienna

Isabella Ellinger:

Podgorzak Victoria: BSc Molekulare Biotechnologie. Eisentransport in der humanen Plazenta. (01/2017 – 07/2017) FH Campus Vienna

Török Sophie: BSc Biomedizinische Analytik. Die Rolle von Ferroportin im plazentaren Einsentransport: Konzeptionierung eines Untersuchungssystems der Ferroportin Proteinexpression. (01/2017 – 06/2017) FH Campus Vienna

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology b) Diploma, MDiploma and Master students: n = 13

Isabella Ellinger:

Jungwirth Christoph: MDiplomaThesis: Validierung der Segmentierung bei der automatischen quantitativen Immunhistochemie: Einfluss der Inter-Rater-Variabilität auf die in situ-Quantifizierung von Proteinen im plazentaren Endothelzellen. (09/2014 – in progress) Medical University of Vienna

Kemper Jost: MDiploma Thesis: Mercury transport across the placental barrier: Expression and localization of OAT4 (05/2013 – 04/2017) Medical University of Vienna

Seebacher Wolfgang: MDiploma Thesis. Validierung der Segmentierung bei der automatischen quantitativen Immunhistochemie: Einfluss der Inter-Rater-Variabilität auf die in situ-Quantifizierung von Proteinen im plazentaren Synzytiotrophoblasten.(09/2014 – 07/2017) Medical University of Vienna

Diana Mechtcheriakova:

Oswald Andrea: DiplomaPharm: Quantitative assessment of B-cell subsets: From digital pathology to disease mechanisms attributed to germinal centers: (10/2014 – in progress). University of Vienna.

Weninger Carina: DiplomaPharm: Mikroskopie-basierte Quantifizierung von Ki67 in komplexen Tumorgeweben mit Fokus auf ektopische Lymphoide Strukturen. (09/2017 – in progress) University of Vienna

Peter Pietschmann:

Fraberger Sabine: MDiploma thesis (N203): Knochenstruktur bei Syphilis: Analyse von historischem Knochenmaterial aus präantibiotischer Zeit mittels Mikro-CT (µCT) (02/2015 – 01/2017) Medical University of Vienna

Andreas Grübl: MDiploma thesis: Der Effekt von Gewichtsveränderung, körperlichen Training und hochkalorischer Ernährung auf die Knochenstruktur am Modell der Ratte. (05/2017 – in progress)

Leitner Mathias: MDiploma thesis: Experimentelle Untersuchungen zur Knochenstruktur bei Adipositas. (03/2016 – 07/2017) Medical University of Vienna

Lueger Anna: MDiploman thesis: Einfluss von Gewichtsreduktion, körperliche Bewegung und Einnahme eines spezifischen Appetitzüglers auf die Knochenmikroarchitektur bei adipösen Sprague Dawley Ratten. (10/2017 –in progress)

Marchetti Sebastian: MDiploma thesis: Obesity and ist effects on the structure and microarchitecture of bones in rats. (04/2016 – in progress) Medical University of Vienna

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

Quack Carina: MDiploma thesis: Auswirkungen einer High-Fat-Diät auf die trabekuläre und kortikale Mikrostruktur des Femurs bei männlichen Strague Dawley Ratten. (06/2016 – in progress) Medical University of Vienna

Mathias Schmidt: MDiploma thesis: Knochenstruktur bei Adipositas. (02/2017 – in progress) Medical University of Vienna

Maximilian Stundner: MDiploma thesis: Knochenstruktur bei Adipositas. (02/2017 – in progress) Medical University of Vienna

c) PhD, MDSci, MD students: n =10

Isabella Ellinger:

Ganjian Haleh: PhD thesis (N790): Rhinovirus infections of airway epithelial (02/2013 – in progress) Medical University of Vienna

Klameth Lukas: PhD thesis (N094): Expression of pH-regulators NHE1 (sodium-proton exhchanger 1), MCTs (monocarboxylate transporters) and CAIX (carbonic anhydrase IX) in small cell lung cancer (SCLC) and ovarian cancer cell lines and their role in chemoresistance. (07/2013 –08/2017). Medical University of Vienna

Mahbod Amirreza: PhD thesis (N094): Calcium-Sensing Receptor Biomedicine” – Generation and validation of algorithms used in advanced tissue cytometry. (10/2016 – in progress) Medical University of Vienna

Thesis Committee member:

Föger-Samwald Ursula: PhD thesis (N790): Gene expression, bone turnover markers, and microarchitecture in metabolic bone diseases (02/2013 – 02/2017) Medical University of Vienna

Kalic Tanja: PhD thesis (N094): Characterization of reactions of epithelial cells responsible for high allergenicity of Gad m1, the major allergen from Atlantic cod. (02/2015 – in progress) Medical University of Vienna

Liedauer Richard: PhD thesis (N790): Clinical experimental oncology. (09/2014 – in progress) Medical University of Vienna

Straka Elisabeth: PhD thesis (N790): Mercury toxicokinetics in human placenta.(11/2014 – in progress) Medical University of Vienna.

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

Diana Mechtcheriakova:

Meshcheryakova Anastasia: PhD thesis (N094) Definition of novel breakpoints in the sphingolipid machinery under pathophysiological conditions with particular focus on interconnection with the immune system. (08/2011 – in progress) Medical University of Vienna

Mungenast Felicitas: PhD thesis (N790) Integrative approach to define B cell-attributed checkpoints at tumor site (02/2015 – in progress) Medical University of Vienna

Peter Pietschmann:

Föger-Samwald Ursula: PhD thesis (N790): Gene expression, bone turnover markers, and microarchitecture in metabolic bone diseases (02/2013 – 02/2017) Medical University of Vienna

Raimann Adalbert: PhD thesis (N790): Impact of FGF23 on growth plate chondrocytes. (12/2013 – in progress) Medical University of Vienna

Vekszler György: PhD thesis (N790). Micro architecture of historic bone samples with tuberculosis. (10/2014- in progress) ) Medical University of Vienna

Florian Wagner: PhD thesis (N790). Morphometric modelling and atlas based segmentation of the midface. (10/2014 – 10/2017) Medical University of Vienna (senior supervisor)

Wakolbinger Robert: PhD thesis (N790). Bone microarchitecture in patients suffering from hepatic cirrhosis: A high-resolution peripheral quantitative computed tomography study. (09/2014 – in progress) Medical University of Vienna (senior supervisor)

Thesis committee member:

Bieder Daniela: PhD thesis (N790). Roles of galectins in joint tissues (05/2014 – in progress) Medical University of Vienna

Elshamly Mahmoud: PhD thesis (N790).Glycophenotyping of lumbar disc degeneration and correlation with patient age, magnetic resonance imaging and histopathological grading. (07/2015 – in progress) Medical University of Vienna

Köttsdorfer Julia: PhD thesis (N790). The role of selected cytokines during human fracture healing. (05/2014 – in progress) Medical University of Vienna

Nicolas Haffner: PhD thesis (N790). Differences in adhesion and biofilm formation of 2 different staphylococcus strains (S. epidermis and S. aureus) on highly-crosslinked UHMWPE (Rexpol) compared to mixed oxide ceramics (Biolox) (03/2015 – in progress) Medical University of Vienna

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

Panzenböck Lukas: Reducing postoperative surgical site infection by topical, intrawound application of vancomycin powder in spinal fusion surgery – a prospective randomized controlled trial. (07/2015 – in progress)

Walzer Sonja: PhD thesis (N790). Differentiation potential of stem/progenitor cells in the human growth plate. (03/2014 – in progress) Medical University of Vienna

Talente: Praktika für Schülerinnen und Schüler 2017

Isabella Ellinger:

Lorencic Paulina: „Thema: FeTransport Plazenta“, Piaristengymansium Bg8, Wien, 10.7.2017 – 4.8.2017

Shadova Katrin: „Thema: FeTransport Plazenta“, BG/BRG Perchtoldsdorf, 10.7.2017 – 4.8.2017

Tursunovic Amra: „Thema: FeTransport Plazenta“, HBLVA Rosensteingasse, Wien, 10.7.2017 – 4.8.2017

Waidmann Aaron: „Thema: FeTransport Plazenta“, HTL Spengergasse, Wien, 10.7.2017 – 4.8.2017

Peter Pietschmann:

Weilgony Barbara: „Thema Knochenhistologie “, Realgymnasium und Wirtschaftskundliches Bundesrealgymnasium, Anton-Baumgartner-Straße 123, 1230 Wien, 3.7.2017 – 28.7.2017

f) coordination of doctoral programs:

Peter Pietschmann:

Coordinator of the doctoral program “Regeneration of Bone and Joints”

1.2.14. Exams a) Oral examinations: n = 0 b) Diploma and Thesis-Examinations: n = 15

Isabella Ellinger:

Jost Kemper, MD Diploma Examination, 6.4.2017 Mathias Leitner, MD Diploma (N202), 17.7.2017 Wolfgang Seebacher, MD Diploma (N202), 21.7.2017

Peter Pietschmann:

Sabine Fraberger, MD Diploma Examination (N203), 12.1.2017 Emir Benca, PhD Thesis Examination (N790), 15.2.2017 69

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

Daniela Weinmann, PhD Thesis Examination (N790), 12.4.2017 Lukas Mathias Hingsammer, PhD Thesis Examination (N790), 22.5.2017 Anna Katschnig, PhD Thesis Examination (N094), 21.6.2017 Sandra Haider, PhD Thesis Examination (N094), 22.6.2017 Georg Djordje Strbac, PhD Thesis Examination (N090), 13.7.2017 Mathias Leitner, MD Diploma (N202), 17.7.2017 Stefan Salminger, PhD Thesis Examination (N094), 21.7.2017 Ceeneena Ubaidha Maheen, PhD Thesis Examination (N094), 10.10.2017 Sandra Elisabeth Bösmüller, PhD Thesis Examination (N790), 16.10.2017 Katayoon Changi, PhD Thesis Examination (N094), 16.11.2017 Victoria Saferding, PhD Thesis Examination (N094), 21.12.2017

c) Exam supervising: n = 1

Isabella Ellinger:

SSM1: 18.10.2017, 16:45 – 19:00

d) Reviewing of Doctoral Thesis: n = 5

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

1.2.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2017 Ellinger Isabella 2.27 1.60 802001 BL 4 - Funktionssysteme und biologische Regulation Ellinger Isabella 1.00 2.00 806009 Ärztliche Gesprächsführung B Ellinger Isabella 1.00 0.33 850021 Creative and critical Journal Club Ellinger Isabella 1.00 0.25 850022 TS: Stimulating Friday Seminar Fuchs Renate 2.27 4.00 802001 BL 4 - Funktionssysteme und biologische Regulation Mechtcheriakova Diana 1.00 0.25 850022 TS: Stimulating Friday Seminar Pietschmann Peter 2.53 0.20 804000 BL 10 - Endokrinologie und Stoffwechsel Pietschmann Peter 4.00 0.50 808004 SSM 3-Projektstudie (Wahlpflichtteil) Pietschmann Peter 2.00 0.50 850102 Thesis Seminar (TS Bones and Joint Regeneration) Pietschmann Peter 1.00 0.33 850021 Creative and critical Journal Club Pietschmann Peter 1.00 0.25 850022 TS: Stimulating Friday Seminar Pietschmann Peter 2.00 0.15 860220 Basisvorlesung Immunologie Pietschmann Peter 2.00 0.70 860302 Dissertantenseminar: Durchflusszytometrie - Methodik und immunologische Anwendungsmöglichkeiten Pietschmann Peter 2.00 0.18 870012 Medical Propedeutics I - Anatomy & Physiology - SS 2016 Pietschmann Peter 2.00 1.00 881005 Pathophysiology for Biotechnologists Thalhammer Theresia 2.00 0.05 860028 PS: "Clinical Endocrinology, Metabolism and Nutrition SS 2017 (Wahpflichtfach, compulsory optional course) Sum 12.29

WS 2017/18 Ellinger Isabella 1.13 2.13 801001 BL 1 - Gesunde und kranke Menschen Ellinger Isabella 2.00 0.67 801004 BL 2 - Der menschliche Körper Ellinger Isabella 6.27 0.40 801005 BL 3 - Vom Molekül zur Zelle Ellinger Isabella 1.73 1.87 801006 BL 3 - Vom Molekül zur Zelle Ellinger Isabella 0.50 0.93 803001 BL 7 - Wissenschaft und Medizin (SSM 1) Ellinger Isabella 2.50 2.50 803074 SSM 1 - Die Rolle von AGEs und RAGE in chronischen Erkrankungen Ellinger Isabella 2.27 0.27 805002 BL 14 - Niere und Homöostase Ellinger Isabella 3.00 0.30 840052 Medizinisches Propädeutikum Teil 1 Ellinger Isabella 1.00 0.25 850029 TS: Stimulating Friday Seminar

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

Ellinger Isabella 1.00 0.33 850028 Creative and critical Journal Club Ellinger Isabella 2.00 0.12 850101 Basic Lectures Föger-Samwald Ursula 1.13 1.60 801001 BL 1 - Gesunde und kranke Menschen Föger-Samwald Ursula 2.00 0.40 801004 BL 2 - Der menschliche Körper Föger-Samwald Ursula 0.50 0.80 803001 BL 7 - Wissenschaft und Medizin (SSM 1) Föger-Samwald Ursula 3.00 0.30 840052 Medizinisches Propädeutikum Teil 1 Fuchs Renate 1.13 4.00 801001 BL 1 - Gesunde und kranke Menschen Mechtcheriakova Diana 2.00 0.66 648802 Progress Report in Comparative Allergology, Oncology and Immunology Mechtcheriakova Diana 1.00 0.25 850029 TS: Stimulating Friday Seminar Pietschmann Peter 2.00 0.70 653346 Dissertantenseminar: Durchflusszytometrie - Methodik und immunologische Anwendungsmöglichkeiten Pietschmann Peter 5.80 0.40 803002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Pietschmann Peter 2.00 0.25 850101 Basic Lectures Pietschmann Peter 4.00 0.13 807002 BL 21 - Bewegung und Leistung, Schmerz Pietschmann Peter 4.53 0.07 807009 BL 22/23 - Public Health Pietschmann Peter 5.87 1.07 825001 BL Z-1 Kau- und Bewegungsapparat Pietschmann Peter 1.00 0.11 850081 Journal Club (Doctoral Program N790 "Bones and Joint Regeneration") Pietschmann Peter 2.00 0.67 850082 Thesis Seminar (Doctoral Program N790 "Bones and Joint Regeneration") Pietschmann Peter 2.00 0.33 850971 Practical Seminar (Doctoral Program N790 "Bones and Joint Regeneration") Pietschmann Peter 1.00 0.25 850029 TS: Stimulating Friday Seminar Pietschmann Peter 1.00 0.33 850028 Creative and critical Journal Club Pietschmann Peter 2.00 0.06 860492 Basic Seminar "Endocrinology and Metabolism" (Wahlpflichtfach) Thalhammer Theresia 2.00 0.06 860490 JC Endocrinology and Metabolism WS 2017 Thalhammer Theresia 2.00 0.06 860491 TS Endocrinology and Metabolism WS 2017 Thalhammer Theresia 2.00 0.06 860492 Basic Seminar “Endocrinology and Metabolism” Sum 22.33 Total sum SS+WS 34.62

Performance Report 2017 – Division 2 Cellular and Molecular Pathophysiology

Lectures, Seminars, Lab Courses at other Universities SWST pro-rata LV Nr. SS 2017 Pietschmann Peter 0,18 Comparative Pathophysiology & Pathology (University of Veterinary Medicine)

WS 2017/18 Ellinger Isabella 0.50 Interdisciplinary Master Comparative Medicine (University of Veterinary Medicine) Ellinger Isabella 0.07 Primary Immunodeficiency Diseases (Karl Landsteiner Privatuniversität) Ellinger Isabella n.d. Coordination of Modul 7 (Karl Landsteiner Universität) Pietschmann Peter 0.13 Comparative Anatomy, Physiology and Genetics (University of Veterinary Medicine)

Total sum SS+WS 0.88

Performance Report 2017 – Division 3 Immunopathology

1.3. Division for Immunpathology Head: Valenta Rudolf, MD, Professor

1. Publications6 pro-rata IF Number Top/Std/Subst Flicker Sabine 3.587 2 1 Top / 1 Std. Focke-Tejkl Margarete 16.703 9 8 Top/ 1 Std. Linhart Birgit 25.091 5 4 Top / 1 Std. Mittermann Irene 0.693 1 1 Std. Valenta Rudolf 130.332 34 21 Top / 8 Std. / 5 n.V. Vrtala Susanne 25.106 9 7 Top / 2 n.V. Division-Sum 161.490 39 Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2

2. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Flicker Sabine 1 1 Focke-Tejkl Margarete 1 2 Linhart Birgit 1 Mittermann Irene 2 Valenta Rudolf 4 Vrtala Susanne 2 Sum 1 1 12

3. Teaching SS* WS* total W+S Exams Flicker Sabine 0.25 0.65 0.9 Focke-Tejkl Margarete 2.13 3.31 5.44 Linhart Birgit 0.0 0.0 0.0 Mittermann Irene 0.0 0.4 0.4 Valenta Rudolf 11.19 14.01 25.2 Vrtala Susanne 0.13 5.07 5.2 Sum 13.7 23.44 37.14

6 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications. 75

Performance Report 2017 – Division 3 Immunopathology

1.3.1. Publications

a) Peer-reviewed original articles: n = 35

Nr. Article IF Class pro-rata IF 1) Aguilar D, Pinart M, Koppelman GH, Saeys Y, Nawijn MC, 2.806 Std 0.561 Postma DS, Akdis M, Auffray C, Ballereau S, Benet M, García-Aymerich J, González JR, Guerra S, Keil T, Kogevinas M, Lambrecht B, Lemonnier N, Melen E, Sunyer J, Valenta R, Valverde S, Wickman M, Bousquet J, Oliva B, Antó JM. Computational analysis of multimorbidity between asthma, eczema and rhinitis. PLoS One. 2017 Jun 9;12(6):e0179125. doi: 10.1371/journal.pone.0179125. eCollection 2017.

2) Asarnoj A, Hamsten C, Lupinek C, Melén E, Andersson N, 13.081 Top 2.616 Anto JM, Bousquet J, Valenta R, van Hage M, Wickman M; MeDALL Consortium. Prediction of peanut allergy in adolescence by early childhood storage protein-specific IgE signatures: The BAMSE population-based birth cohort. J Allergy Clin Immunol. 2017 Aug;140(2):587-590.e7. doi: 10.1016/j.jaci.2016.12.973.

3) Berings M, Arasi S, De Ruyck N, Perna S, Resch Y, Lupinek 13.081 Top 2.616 C, Chen KW, Vrtala S, Pajno GB, Bachert C, Lambrecht BN, Dullaers M, Valenta R, Matricardi PM, Gevaert P. Reliable mite-specific IgE testing in nasal secretions by means of allergen microarray. J Allergy Clin Immunol. 2017 Jul;140(1):301-303.e8. doi:10.1016/j.jaci.2016.11.047.

4) Bousquet J, Farrell J, Crooks G, Hellings P, Bel EH, Bewick 3.239 Std 0.648 M, Chavannes NH, de Sousa JC, Cruz AA, Haahtela T, Joos G, Khaltaev N, Malva J, Muraro A, Nogues M, Palkonen S, Pedersen S, Robalo-Cordeiro C, Samolinski B, Strandberg T, Valiulis A, Yorgancioglu A, Zuberbier T, Bedbrook A, Aberer W, Adachi M, Agusti A, Akdis CA, Akdis M, Ankri J, Alonso A, Annesi-Maesano I, Ansotegui IJ, Anto JM, Arnavielhe S, Arshad H, Bai C, Baiardini I, Bachert C, Baigenzhin AK, Barbara C, Bateman ED, Beghé B, Kheder AB, Bennoor KS, Benson M, Bergmann KC, Bieber T, Bindslev-Jensen C, Bjermer L, Blain H, Blasi F, Boner AL, Bonini M, Bonini S, Bosnic-Anticevitch S, Boulet LP, Bourret R, Bousquet PJ, Braido F, Briggs AH, Brightling CE, Brozek J, Buhl R, Burney PG, Bush A, Caballero-Fonseca F, Caimmi D, Calderon MA, Calverley PM, Camargos PAM, Canonica GW, Camuzat T, Carlsen KH, Carr W, Carriazo A, Casale T, Cepeda Sarabia AM, Chatzi L, Chen YZ, Chiron R, Chkhartishvili E, Chuchalin AG, Chung KF, Ciprandi G, Cirule I, Cox L, Costa DJ, Custovic A, Dahl R, Dahlen SE, Darsow U, De Carlo G, De Blay F, Dedeu T, Deleanu D, De Manuel Keenoy E, Demoly P, Denburg JA, Devillier P, Didier A, Dinh-Xuan AT, Djukanovic R, Dokic D, Douagui H, Dray G, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, Emuzyte R, Fabbri LM, Fletcher M, Fiocchi A, Fink Wagner A, Fonseca J, Fokkens WJ, Forastiere F, Frith P, Gaga M, Gamkrelidze A,

Performance Report 2017 – Division 3 Immunopathology

Nr. Article IF Class pro-rata IF Garces J, Garcia-Aymerich J, Gemicioğlu B, Gereda JE, González Diaz S, Gotua M, Grisle I, Grouse L, Gutter Z, Guzmán MA, Heaney LG, Hellquist-Dahl B, Henderson D, Hendry A, Heinrich J, Heve D, Horak F, Hourihane JOB, Howarth P, Humbert M, Hyland ME, Illario M, Ivancevich JC, Jardim JR, Jares EJ, Jeandel C, Jenkins C, Johnston SL, Jonquet O, Julge K, Jung KS, Just J, Kaidashev I, Khaitov MR, Kalayci O, Kalyoncu AF, Keil T, Keith PK, Klimek L, Koffi N'Goran B, Kolek V, Koppelman GH, Kowalski, ML, Kull I, Kuna P, Kvedariene V, Lambrecht B, Lau S, Larenas- Linnemann D, Laune D, Le LTT, Lieberman P, Lipworth B, Li J, Lodrup Carlsen K, Louis R, MacNee W, Magard Y, Magnan A, Mahboub B, Mair A, Majer I, Makela MJ, Manning P, Mara S, Marshall GD, Masjedi MR, Matignon P, Maurer M, Mavale-Manuel S, Melén E, Melo-Gomes E, Meltzer EO, Menzies-Gow A, Merk H, Michel JP, Miculinic N, Mihaltan F, Milenkovic B, Mohammad GMY, Molimard M, Momas I, Montilla-Santana A, Morais-Almeida M, Morgan M, Mösges R, Mullol J, Nafti S, Namazova-Baranova L, Naclerio R, Neou A, Neffen H, Nekam K, Niggemann B, Ninot G, Nyembue TD, O'Hehir RE, Ohta K, Okamoto Y, Okubo K, Ouedraogo S, Paggiaro P, Pali-Schöll I, Panzner P, Papadopoulos N, Papi A, Park HS, Passalacqua G, Pavord I, Pawankar R, Pengelly R, Pfaar O, Picard R, Pigearias B, Pin I, Plavec D, Poethig D, Pohl W, Popov TA, Portejoie F, Potter P, Postma D, Price D, Rabe KF, Raciborski F, Radier Pontal F, Repka-Ramirez S, Reitamo S, Rennard S, Rodenas F, Roberts J, Roca J, Rodriguez. Mañas L, Rolland C, Roman Rodriguez M, Romano A, Rosado-Pinto J, Rosario N, Rosenwasser L, Rottem M, Ryan D, Sanchez-Borges M, Scadding GK, Schunemann HJ, Serrano E, Schmid-Grendelmeier P, Schulz H, Sheikh A, Shields M, Siafakas N, Sibille Y, Similowski T, Simons FER, Sisul JC, Skrindo I, Smit HA, Solé D, Sooronbaev T, Spranger O, Stelmach R, Sterk PJ, Sunyer J, Thijs C, To T, Todo-Bom, A, Triggiani M, Valenta R, Valero AL, Valia E, Valovirta E, Van Ganse E, van Hage M, Vandenplas O, Vasankari T, Vellas B, Vestbo J, Vezzani G, Vichyanond P, Viegi G, Vogelmeier C, Vontetsianos T, Wagenmann M, Wallaert B, Walker S, Wang DY, Wahn U, Wickman M, Williams DM, Williams S, Wright J, Yawn BP, Yiallouros PK, Yusuf OM, Zaidi A, Zar HJ, Zernotti ME, Zhang L, Zhong N, Zidarn M, Mercier J. Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3:Area 5). Clin Transl Allergy. 2017 Feb 20;7:5. doi: 10.1186/s13601-016-0135-6.

5) Cabauatan CR, Campana R, Niespodziana K, Reinisch C, 7.361 Top 7.361 Lundberg U, Meinke A, Henning R, Neubauer A, Valenta R. Heat-labile Escherichia coli toxin enhances the induction of allergen-specific IgG antibodies in epicutaneous patch vaccination. Allergy. 2017 Jan;72(1):164-168. doi: 10.1111/all.13036.

Performance Report 2017 – Division 3 Immunopathology

Nr. Article IF Class pro-rata IF 6) Campana R, Moritz K, Neubauer A, Huber H, Henning R, 4.259 Top 4.259 Brodie TM, Kaider A, Sallusto F, Wöhrl S, Valenta R. Epicutaneous allergen application preferentially boosts specific T cell responses in sensitized patients. Sci Rep. 2017 Sep 14;7(1):11657. doi: 10.1038/s41598-017-10278-1.

7) Conti A, Burastero GJ, Suli C, Banerjee S, Vrtala S, Alessio 3.914 Top 0.783 M, Burastero SE. Identification by serological proteome analysis of paramyosin as prominent allergen in dust mite allergy. J Proteomics. 2017 Aug 23;166:19-26. doi: 10.1016/j.jprot.2017.06.024

8) Curin M, Garib V, Valenta R. Single recombinant and 3.728 Std 3.728 purified major allergens and peptides: How they are made and how they change allergy diagnosis and treatment. Ann Allergy Asthma Immunol. 2017 Sep;119(3):201-209. doi:10.1016/j.anai.2016.11.022.

9) Curin M, Weber M, Hofer G, Apostolovic D, Keller W, 4.259 Top 4.259 Reininger R, Swoboda I, Spitzauer S, Focke-Tejkl M, van Hage M, Valenta R. Clustering of conformational IgE epitopes on the major dog allergen Can f 1. Sci Rep. 2017 Sep 22;7(1):12135. doi: 10.1038/s41598-017-11672-5.

10) Freidl R, Gstoettner A, Baranyi U, Swoboda I, Stolz F, 13.081 Top 13.081 Focke-Tejkl M, Wekerle T, van Ree R, Valenta R, Linhart B. Blocking antibodies induced by immunization with a hypoallergenic parvalbumin mutant reduce allergic symptoms in a mouse model of fish allergy. J Allergy Clin Immunol. 2017 Jun;139(6):1897-1905.e1. doi: 10.1016/j.jaci.2016.10.018.

11) G arib V, Wollmann E, Djambekova G, Lemell P, Kmenta M, 7.361 Top 7.361 Berger U, Zieglmayer P, Valenta R. Possible effect of landscape design on IgE recognition profiles of two generations revealed with micro-arrayed allergens. Allergy. 2017 Oct;72(10):1579-1582. doi: 10.1111/all.13169.

12) Göbl C, Focke-Tejkl M, Najafi N, Schrank E, Madl T, Kosol 13.081 Top 13.081 S, Madritsch C, Dorofeeva Y, Flicker S, Thalhamer J, Valenta R, Zangger K, Tjandra N. Flexible IgE epitope- containing domains of Phl p 5 cause high allergenic activity. J Allergy Clin Immunol. 2017 Oct;140(4):1187-1191. doi: 10.1016/j.jaci.2017.05.005.

13) Hellings PW, Fokkens WJ, Bachert C, Akdis CA, Bieber T, 7.361 Top 1.472 Agache I, Bernal-Sprekelsen M, Canonica GW, Gevaert P, Joos G, Lund V, Muraro A, Onerci M, Zuberbier T, Pugin B, Seys SF, Bousquet J; ARIA and EPOS working groups. Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis - A EUFOREA-ARIA-EPOS-AIRWAYS ICP statement. Allergy. 2017 Sep;72(9):1297-1305. doi: 10.1111/all.13162.

Performance Report 2017 – Division 3 Immunopathology

Nr. Article IF Class pro-rata IF 14) Hochwallner H, Schulmeister U, Swoboda I, Focke-Tejkl M, 7.361 Top 7.361 Reininger R, Civaj V, Campana R, Thalhamer J, Scheiblhofer S, Balic N, Horak F, Ollert M, Papadopoulos NG, Quirce S, Szepfalusi Z, Herz U, van Tol EA, Spitzauer S, Valenta R. Infant milk formulas differ regarding their allergenic activity and induction of T-cell and cytokine responses. Allergy. 2017 Mar;72(3):416-424. doi: 10.1111/all.12992. Epub 2016 Sep 18.

15) Kollmann D, Nagl B, Ebner C, Emminger W, Wöhrl S, 7.361 Top 1.472 Kitzmüller C, Vrtala S, Mangold A, Ankersmit HJ, Bohle B. The quantity and quality of α-gal-specific antibodies differ in individuals with and without delayed red meat allergy. Allergy. 2017 Feb;72(2):266-273. doi: 10.1111/all.12948

16) Kowalski ML, Ansotegui I, Aberer W, Al-Ahmad M, Akdis M, 0.00 n.V. 0.00 Ballmer-Weber BK, Beyer K, Blanca M, Brown S, Bunnag C, Hulett AC, Castells M, Chng HH, De Blay F, Ebisawa M, Fineman S, Golden DB, Haahtela T, Kaliner M, Katelaris C, Lee BW, Makowska J, Muller U, Mullol J, Oppenheimer J, Park HS, Parkerson J, Passalacqua G, Pawankar R, Renz H, Rueff F, Sanchez-Borges M, Sastre J, Scadding G, Sicherer, S, Tantilipikorn P, Tracy J, van Kampen V, Bohle B, Canonica GW, Caraballo L, Gomez M, Ito K, Jensen-Jarolim E, Larche M, Melioli G, Poulsen LK, Valenta R, Zuberbier T. Erratum to: Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement. World Allergy Organ J. 2017 Jan 11;10(1):6. doi: 10.1186/s40413-016-0134-z.

17) Lupinek C, Derfler K, Lee S, Prikoszovich T, Movadat O, 0.00 n.V. 0.00 Wollmann E, Cornelius C, Weber M, Fröschl R, Selb R, Blatt K, Smiljkovic D, Schoder V, Cervenka R, Plaichner T, Stegfellner G, Huber H, Henning R, Kozik-Jaromin J, Perkmann T, Niederberger V, Petkov V, Valent P, Gauly A, Leinenbach HP, Uhlenbusch-Koerwer Valenta R. Extracorporeal IgE Immunoadsorption in Allergic Asthma: Safety and Efficacy. EBioMedicine. 2017 Mar;17:119-133. doi: 10.1016/j.ebiom.2017.02.007.

18) Mothes -Luksch N, Raith M, Stingl G, Focke-Tejkl M, 7.361 Top 1.472 Razzazi-Fazeli E, Zieglmayer R, Wöhrl S, Swoboda I. Pru p 3, a marker allergen for lipid transfer protein sensitization also in Central Europe. Allergy. 2017 Sep;72(9):1415-1418. doi: 10.1111/all.13151.

19) Narayanan M, Freidl R, Focke-Tejkl M, Baranyi U, Wekerle 4.856 Std 4.856 T, Valenta R, Linhart B. A B Cell Epitope Peptide Derived from the Major Grass Pollen Allergen Phl p 1 Boosts Allergen-Specific Secondary Antibody Responses without Allergen-Specific T Cell Help. J Immunol. 2017 Feb 15;198(4):1685-1695. doi: 10.4049/jimmunol.1501741.

Performance Report 2017 – Division 3 Immunopathology

Nr. Article IF Class pro-rata IF 20) Oida K, Einhorn L, Herrmann I, Panakova L, Resch Y, Vrtala 0.00 n.V. 0.00 S, Hofstetter G, Tanaka A, Matsuda H, Jensen-Jarolim E. Innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated pH. World Allergy Organ J. 2017 Jul 4;10(1):23. doi: 10.1186/s40413-017-0154-3. eCollection 2017.

21) Peng W, Grobe W, Walgenbach-Brünagel G, Flicker S, Yu 4.856 Std 0.971 C, Sylvester M, Allam JP, Oldenburg J, Garbi N, Valenta R, Novak N. Distinct Expression and Function of FcεRII in Human B Cells and Monocytes. J Immunol. 2017 Apr 15;198(8):3033-3044. doi: 10.4049/jimmunol.1601028.

22) Posa D, Perna S, Resch Y, Lupinek C, Panetta V, Hofmaier 13.081 Top 2.616 S, Rohrbach A, Hatzler L, Grabenhenrich L, Tsilochristou O, Chen KW, Bauer CP, Hoffman U, Forster J, Zepp F, Schuster A, Wahn U, Keil T, Lau S, Vrtala S, Valenta R, Matricardi PM. Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life. J Allergy Clin Immunol. 2017 Feb;139(2):541-549.e8. doi: 10.1016/j.jaci.2016.08.014.

23) Saltabayeva U, Garib V, Morenko M, Rosenson R, Ispayeva 2.720 Std 2.720 Z, Gatauova M, Zulus L, Karaulov A, Gastager F, Valenta R. Greater Real-Life Diagnostic Efficacy of Allergen Molecule- Based Diagnosis for Prescription of Immunotherapy in an Area with Multiple Pollen Exposure. Int Arch Allergy Immunol. 2017;173(2):93-98. doi: 10.1159/000477442.

24) Sánchez -Borges M, Fernandez-Caldas E, Thomas WR, 0.00 n.V. 0.00 Chapman MD, Lee BW, Caraballo L, Acevedo N, Chew FT, Ansotegui IJ, Behrooz L, Phipatanakul W, Gerth van Wijk R, Pascal D, Rosario N, Ebisawa M, Geller M, Quirce S, Vrtala S, Valenta R, Ollert M, Canonica GW, Calderón MA, Barnes CS, Custovic A, Benjaponpitak S, Capriles-Hulett A. International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem. World Allergy Organ J. 2017 Apr 18;10(1):14. doi: 10.1186/s40413-017-0145-4.

25) Selb R, Eckl-Dorna J, Neunkirchner A, Schmetterer K, Marth 13.081 Top 2.616 K, Gamper J, Jahn-Schmid B, Pickl WF, Valenta R, Niederberger V. CD23 surface density on B cells is associated with IgE levels and determines IgE-facilitated allergen uptake, as well as activation of allergen-specific T cells. J Allergy Clin Immunol. 2017 Jan;139(1):290-299.e4. doi: 10.1016/j.jaci.2016.03.042.

26) Selb R, Eckl-Dorna J, Twaroch TE, Lupinek C, Teufelberger 13.081 Top 2.616 A, Hofer G, Focke-Tejkl M, Gepp B, Linhart B, Breiteneder H, Ellinger A, Keller W, Roux KH, Valenta R, Niederberger V. Critical and direct involvement of the CD23 stalk region in IgE binding. J Allergy Clin Immunol. 2017 Jan;139(1):281-289.e5. doi: 10.1016/j.jaci.2016.04.015.

Performance Report 2017 – Division 3 Immunopathology

Nr. Article IF Class pro-rata IF 27) Shamji MH, Kappen JH, Akdis M, Jensen-Jarolim E, Knol EF, 7.361 Top 1.472 Kleine-Tebbe J, Bohle B, Chaker AM, Till SJ, Valenta R, Poulsen LK, Calderon MA, Demoly P, Pfaar O, Jacobsen L, Durham SR, Schmidt-Weber CB. Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper. Allergy. 2017 Aug;72(8):1156-1173. doi: 10.1111/all.13138.

28) Siroux V, Lupinek C, Resch Y, Curin M, Just J, Keil T, Kiss 13.081 Top 2.616 R, Lødrup Carlsen K, Melén E, Nadif R, Pin I, Skrindo I, Vrtala S, Wickman M, Anto JM, Valenta R, Bousquet J. Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study. J Allergy Clin Immunol. 2017 Feb;139(2):643-654.e6. doi: 10.1016/j.jaci.2016.05.023.

29) Smiljkovic D, Blatt K, Stefanzl G, Dorofeeva Y, Skrabs C, 7.361 Top 1.472 Focke-Tejkl M, Sperr WR, Jaeger U, Valenta R, Valent P. BTK inhibition is a potent approach to block IgE-mediated histamine release in human basophils. Allergy. 2017 Nov;72(11):1666-1676. doi: 10.1111/all.13166.

30) Valenta R. Mucosal Lining Fluid Biomarkers in Asthma: 0.00 n.V. 0.00 Basis for Rational Use of New Targeted Therapies? EBioMedicine. 2017 May;19:12-13. doi: 10.1016/j.ebiom.2017.04.016.

31) Valenta R. Oral tolerance induction in allergy: Kissing awake 9.611 Top 9.611 a sleeping beauty. Semin Immunol. 2017 Apr;30:1-2. doi: 10.1016/j.smim.2017.08.016.

32) van Hage M, Hamsten C, Valenta R. ImmunoCAP assays: 13.081 Top 13.081 Pros and cons in allergology. J Allergy Clin Immunol. 2017 Oct;140(4):974-977. doi: 10.1016/j.jaci.2017.05.008.

33) Weber M, Niespodziana K, Linhart B, Neubauer A, Huber 13.081 Top 13.081 H, Henning R, Valenta R, Focke-Tejkl M. Comparison of the immunogenicity of BM32, a recombinant hypoallergenic B cell epitope-based grass pollen allergy vaccine with allergen extract-based vaccines. J Allergy Clin Immunol. 2017 Nov;140(5):1433-1436.e6. doi: 10.1016/j.jaci.2017.03.048.

34) Wickman M, Lupinek C, Andersson N, Belgrave D, Asarnoj 0.00 n.V. 0.00 A, Benet M, Pinart M, Wieser S, Garcia-Aymerich J, Baar A, Pershagen G, Simpson A, Kull I, Bergström A, Melén E, Hamsten C, Antó JM, Bousquet J, Custovic A, Valenta R, van Hage M. Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence. EBioMedicine. 2017 Dec;26:91-99. doi: 10.1016/j.ebiom.2017.11.009.

35) Zieglmayer P, Lemell P, Wei Chen K, Schmutz R, 13.081 Top 13.081 Zieglmayer R, Pfaar O, Horak F, Vrtala S. Clinical validation

Performance Report 2017 – Division 3 Immunopathology

Nr. Article IF Class pro-rata IF of a house dust mite environmental challenge chamber model. Journal of Allergy and Clinical Immunology, 2017, July;1:266-288, http://dx.doi.org/10.1016/j.jaci.2016.12.986 sum 247.027 142.940

b) Invited Articles & Reviews with IF: n = 4

Nr. Article IF Class pro-rata IF 1) Anto JM, Bousquet J, Akdis M, Auffray C, Keil T, Momas I, 13.081 Top 2.616 Postma DS, Valenta R, Wickman M, Cambon-Thomsen A, Haahtela T, Lambrecht BN, Lodrup Carlsen KC,Koppelman GH, Sunyer J, Zuberbier T, Annesi-Maesano I, Arno A, Bindslev-Jensen C, De Carlo G, Forastiere F, Heinrich J, Kowalski ML, Maier D, Melén E, Smit HA, Standl M, Wright J, Asarnoj A, Benet M, Ballardini N, Garcia-Aymerich J, Gehring U, Guerra S, Hohmann C, Kull I, Lupinek C, Pinart M, Skrindo I, Westman M, Smagghe D, Akdis C, Andersson N, Bachert C, Ballereau S, Ballester F, Basagana X, Bedbrook A, Bergstrom A, von Berg A, Brunekreef B, Burte E, Carlsen KH, Chatzi L, Coquet JM, Curin M, Demoly P, Eller E, Fantini MP, von Hertzen L, Hovland V, Jacquemin B, Just J, Keller T, Kiss R, Kogevinas M, Koletzko S, Lau S, Lehmann I, Lemonnier N, Mäkelä M, Mestres J, Mowinckel P, Nadif R, Nawijn MC, Pellet J, Pin I, Porta D, Rancière F, Rial-Sebbag E, Saeys Y, Schuijs MJ, Siroux V, Tischer CG, Torrent M, Varraso R, Wenzel K, Xu CJ. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes. J Allergy Clin Immunol. 2017 Feb;139(2):388-399. doi: 10.1016/j.jaci.2016.12.940. Review.

2) Campana R, Dzoro S, Mittermann I, Fedenko E, Elisyutina 3.463 Std 3.463 O, Khaitov M, Karaulov A, Valenta R. Molecular aspects of allergens in atopic dermatitis. Curr Opin Allergy Clin Immunol. 2017 Aug;17(4):269-277. doi: 10.1097/ACI.0000000000000378.

3) Campana2 R, Huang HJ, Freidl R, Linhart B, Vrtala S, 9.611 Top 9.611 Wekerle. T, Karaulov A, Valenta R. Recombinant allergen and peptide-based approaches for allergy prevention by oral tolerance. Semin Immunol. 2017 Apr;30:67-80. doi: 10.1016/j.smim.2017.08.017.

4) Valentas R, Campana R, Niederberger V. Recombinant 2.860 Std 2.860 allergyu vaccines based on allergen-derived B cell epitopes. Immunolm Lett. 2017 Sep;189:19-26. doi: 10.1016/j.imlet.2017.04.015. sum 29.015 18.550

Performance Report 2017 – Division 3 Immunopathology c) Invited Articles & Reviews without IF: n = 0

d) Book contributions: n = 2

1) Gangl, K., V. Niederberger, J.M. Davies, R. Valenta, and A. Nandy. Marker allergens and panallergens in tree and grass pollen allergy. 2017. In Molecular Allergy Diagnostics, J. Kleine-Tebbe and T. Jakob (eds.), Seiten 203-226, Springer International Publishing Switzerland. ISBN 978-3-319-42499-6.

2) Vrtala, S., S. Kull, J. Kleine-Tebbe. Allergens of house dust mites and diagnostics in house dust mite allergy. Kleine-Tebbe, Jakob. 2017 In Molecular Allergy Diagnostics, J. Kleine-Tebbe and T. Jakob (eds.), Seiten 415-428, Springer International Publishing Switzerland. ISBN 978-3-319-42499-6

e) Abstracts, printed in periodicals: n = 0

f) Abstracts, in congress proceedings or abstract books: n = 34

1) Campana R., Niederberger-Leppin V., Eckl-Dorna J., Focke-Tejkl M., Weber M., Neubauer A., Henning R., Valenta, R., Development of an ELISA-based surrogate assay for measuring blocking IgG induced by ait. Allergy - European Journal of Allergy and Clinical Immunology 2017, 72:762.

2) Campana R., V. Niederberger, J. Eckl-Dorna, M. Focke-Tejkl, M. Weber, M. Kmenta, U.E. Berger, A. Neubauer, R. Henning, R. Valenta: Evidence for long term effects of treatment with recombinant B cell epitope-based grass pollen allergy vaccine BM32. Development of an ELISA-based surrogate assay for measuring blocking IgG induced by AIT European Academy of Allergy and Clinical Immunology (EAACI), Helsinki, Finland, June 17-21, 2017.

3) Campana R., V. Niederberger, J. Eckl-Dorna, M. Focke-Tejkl, M. Weber, A. Neubauer, R. Henning, R. Valenta: Development of an ELISA-based surrogate assay for measuring blocking IgG induced by AIT. Annual Meeting of the Austrian Society for Allergy and Immunology, Vienna, Austria, November 23-25, 2017.

4) Campana, R., Niederberger-Leppin V., Eckl-Dorna J., Focke-Tejkl M., Weber M., Kmenta, M., Berger U., Neubauer A., Henning R., Valenta R., Evidence for long term effects of treatment with recombinant B cell epitope- based grass pollen allergy vaccine BM32, Allergy - European Journal of Allergy and Clinical Immunology 2017, 72:371.

5) Cornelius A.F. Carolin, Schoeneweis, K., Georgi, F., Weber M. Niederberger-Leppin V. Zieglmayer, P., Niespodziana, K., Trauner M. Hofer H. Urban, S., Henning, R., Valenta R., The recombinant B cell epitope-based grass pollen vaccine BM32 induces antibodies protecting against hepatitis B virus (HBV) infection, Allergy - European Journal of Allergy and Clinical Immunology 2017, 72:370-371.

6) Dittrich A.M., S. Dzoro, M. Albrecht, C. Dopfer, A. Sauer-Heilborn, F. Ringshausen, B. Tümmler, G. Hansen, R. Valenta, B. Hales, I. Mittermann. Specific IgE production against Staphylococcus aureus, Escherichia coli, Hemophilus influenzae and Pneumococci in cystic fibrosis patients. DZL Annual Meeting, Deutsches Zentrum für Lungenforschung, Munich, Germany, January 30-31, 2017.

Performance Report 2017 – Division 3 Immunopathology

7) Dzoro S., I. Mittermann, M. Nehr M, A.M. Hirschl, G. Wikberg G, C. Johansson, L. Lundeberg, A. Scheynius, A.M. Dittrich, R. Valenta. W 1248-16: Characterization of antibody responses to microbial ‘allergens’. SFB, Work in progress Meeting, Ottenstein, Austria, November 5-7, 2017.

8) Dzoro S., Mittermann I., Resch-Marat Y., Vrtala S., Nehr M., Hirschl AM., Wikberg G., Lundeberg L., Johansson C., Scheynius A., Valenta R: House dust mites as potential carriers for IgE sensitization to bacterial antigens. WAO Symposium on Mite Allergy: From Basics to Clinical Applications, Cartagena, Colombia, September 6–9, 2017.

9) Eccles, J.D., Niespodziana, K., Valenta, R., Turner, R., J.A. Woodfolk. Optimization of High-Dimensional Phenotyping of B Cells for Studying Rhinovirus Infection. Annual Meeting of American Academy of Allergy, Asthma and Immunology (AAAAI), Journal of Allergy and Clinical Immunology 2017, 139:AB12.

10) Farkas A., Baranyi U., Böhmig G., Unger L., Hopf St., Wahrmann M., Regele H., Mahr B., Schwarz Ch., Hock K., Pilat-M., Kristo I., Lupinek Ch., Thalhamer J., Wlodek E., Clatworthy M., Martin J., Pettigrew G., Valenta R., Wekerle T. Allograft Rejection Is Associated with the Development of Functional Ige Specific for Donor Mhc Antigens. Transplant International 2017, 30:8-9.

11) Flicker S., I. Ellinger, E. Waltl, K. Blatt, C. Cabauatan, K. Niespodziana, V. Niederberger, P. Valent, R. Valenta. Antibody conjugates bi-specific for ICAM1 and allergens prevent epithelial penetration of allergens and rhinovirus infection. Deutsche Gesellschaft für Immunologie, Erlangen, Germany, September 10-13, 2017.

12) Flicker S., I. Ellinger, E. Waltl, K. Blatt, C. Cabauatan, K. Niespodziana, V. Niederberger, P. Valent, R. Valenta. Antibody conjugates bi-specific for ICAM1 and allergens prevent epithelial penetration of allergens and rhinovirus infection. 8th CePII Center Retreat, Vienna, Austria, September 19, 2017.

13) Flicker S., I. Ellinger, E. Waltl, K. Blatt, C. Cabauatan, K. Niespodziana, V. Niederberger, P. Valent, R. Valenta. Antibody conjugates bi-specific for ICAM1 and allergens prevent epithelial penetration of allergens and rhinovirus infection. Annual Meeting of the Austrian Society for Allergology and Immunology, Vienna, Austria, November 23–25, 2017.

14) Focke-Tejkl M., M. Weber, S. Flicker, P. Zieglmayer, R. Zieglmayer, P. Lemell, F. Horak, A. Neubauer, F. Stolz , H. Huber, R. Henning, R. Valenta. Quantitative measurement of allergen-specific IgG1 and IgG4 during immunotherapywith the recombinant B cell epitope-based grass pollen allergy vaccine BM32. Allergy - European Journal of Allergy and Clinical Immunology 2017, 72:764

15) Freidl R., A. Gstoettner, U. Baranyi, I. Swoboda, F. Stolz, M. Focke-Tejkl, T. Wekerle, R. van Ree, R. Valenta, B. Linhart. A hypoallergenic parvalbumin mutant induces blocking antibodies that protect fish-allergic mice from anaphylaxis. Annual Meeting of the Austrian Society for Allergology and Immunology, Vienna, Austria, November 23–25, 2017.

16) Freidl R., MSc, Gstoettner A., Baranyi U., PhD, Swoboda I., PhD, Stolz F., PhD, Focke-Tejkl M., PhD, Wekerle T., MD, van Ree R., PhD, Valenta R., MD, and Linhart B., PhD; Annual Meeting DGfI (Deutsche Gesellschaft für Immunologie), Parvalbumin-specific blocking IgG antibodies protect against anaphylactic reactions in a murine model of fish allergy. Erlangen, Germany, September 10–13, 2017.

Performance Report 2017 – Division 3 Immunopathology

17) Freidl, R., Gstoettner, A., Baranyi, U., Swoboda, I., Stolz, F., Focke-Tejkl, M., Wekerle, T., van Ree, R., Valenta, R., Linhart, B. Vaccination with a hypoallergenic parvalbumin mutant induces blocking antibodies that protect from allergic symptoms in a mouse model of fish allergy. YSA PhD Symposium, Vienna, Austria, June 8–9, 2017.

18) Garib V., Lemell P., Kmenta, M., Berger U.; Zieglmayer P., Valenta R., Focke-Tejkl M., Increased occurrence of ash trees in the Vienna area is associated with increasing rates of sensitization to the major ash pollen allergen. Allergy - European Journal of Allergy and Clinical Immunology 2017, 72:358.

19) Gattinger P., C. Lupinek, L- Kalogiros, M. Silar, P. Korosec, N. Novak, R. Valenta, I. Mittermann: The culprit insect but not severity of allergic reactions to bee and wasp venom can be determined by molecular diagnosis. 8th CePII Center Retreat, Vienna, Austria, September 19, 2017.

20) Gattinger P., C. Lupinek, L. Kalogiros, M- Silar, M. Zidarn, P. Korosec, C. Bialas, N. Novak, R. Valenta, I. Mittermann. The culprit insect but not severity of allergic reactions to bee and wasp can be determined by molecular diagnosis. Annual Meeting of the Austrian Society for Allergology and Immunology, Vienna, Austria, November 23 – 25, 2017.

21) Gattinger P., I. Mittermann, C. Lupinek, M. Silar, N. Novak, G. Hofer, W. Keller, R. Valenta: Novel diagnostic marker for cross-reactive carbohydrate determinants (CCD) indicates presence of CCD epitopes in HDM-extract. 8th CePII Center Retreat, Vienna, Austria, September 19, 2017.

22) Huang, HJ., Y. Resch-Marat, A. Rodriguez-Dominguez, KW. Chen, R. Kiss, P,Zieglmayer, R. Zieglmayer, F. Horak, R. Valenta, S. Vrtala. A panel of allergen molecules for IgE-based determination of genuine house dust mite sensitization which is superior to allergen extracts for quantification of specific IgE. WAO Symposiun XI Congress ACAAI, Cartagena de Indias, Colombia, September 6-9, 2017.

23) Huang, HJ., Y. Resch-Marat, A. Rodriguez-Dominguez, KW. Chen, R. Kiss, P Zieglmayer, R. Zieglmayer, F. Horak, R. Valenta, S. Vrtala. A panel of allergen molecules for IgE-based determination of genuine house dust mite sensitization which is superior to allergen extracts for quantification of specific IgE. ÖGAI Annual Meeting, Vienna, Austria, November 23-25, 2017.

24) Huang, HJ., Y. Resch-Marat, A. Rodriguez-Dominguez, KW. Chen, R. Kiss, P, Zieglmayer, R. Zieglmayer, F. Horak, R. Valenta, S. Vrtala. A panel of allergen molecules for IgE-based determination of genuine house dust mite sensitization which is superior to allergen extracts for quantification of specific IgE. 8th retreat of Center for Pathophysiology, Infectiology and Immunology, CePII. Vienna, Austria, September 19, 2017.

25) Ivanov D., M. Focke-Tejkl, R. Kiss, E. Gadermaier, R. Valenta, S. Flicker. Reversion of a birch pollen allergen, Bet v 1-specific human IgG-derived ScFv into germline configuration. Annual Meeting of the Austrian Society for Allergology and Immunology, Vienna, Austria, November 23–25, 2017.

26) Kowalski M., Ansotegui I., Aberer W., Al-Ahmad M., Akdis M., Ballmer-Weber B., Beyer K., Blanca M., Brown S., Bunnag Ch., Hulett A., Castells M., Chng H. H., De Blay F., Ebisawa M., Fineman St., Golden D., Haahtela T., Kaliner M., Katelaris C., Lee B., Makowska J., Mullol J., Oppenheimer J., Park H. S., Parkerson J., 85

Performance Report 2017 – Division 3 Immunopathology

Passalacqua G., Pawankar R., Renz H., Rueff F., Sanchez-Borges M., Sastre J., Scadding G., Sicherer S., Tantilipikorn P., Tracy J., Kampen V., Bohle B., Canonica G. W., Caraballo L., Gomez M., Ito K., Jensen-Jarolim E., Larche M., Melioli G. Poulsen L., Valenta R., Zuberbier T., "Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement (vol 9, 33, 2016). WAO Journal 2017, 10:6.

27) Lupinek Christian, Gallerano D., Kiss R., Horak F., Kmenta M., Berger U.E., Valenta R: Decrease of allergen-specific IgE measured by microarray may predict clinical efficacy of subcutaneous immunotherapy, Annual Meeting of the Austrian Society for Allergology and Immunology, Vienna, Austria, November 23–25, 2017.

28) Niederberger-Leppin V., Weber M., Focke-Tejkl M., Eckl-Dorna J., Neubauer A., Valenta R., Immunotherapy with the recombinant B cell epitope-based grass pollen vaccine, BM32, does not induce IgE responses and may be suitable for prophylactic vaccination. Allergy - European Journal of Allergy and Clinical Immunology 2017, 72:371.

29) Niespodziana K., K. Stenberg-Hammar, C. Cabauatan, K. Napora-Wijata, P. Vacal, D. Gallerano, C. Lupinek, et al: PreDicta chip reveals rhinovirus infections as the major trigger of wheezing attacks in preschool children. 8th CePII Center Retreat, Vienna, Austria, September 19, 2017.

30) Rodriguez Dominguez A., Resch Y., Zieglmayer P., Valenta R., Vrtala S: Association of IgE profiles to micro-arrayed house dust mite (HDM) allergens with allergic symptoms measured in a house dust mite challenge chamber. Oral presentation. WAO Symposium, ACAAI Congress, Cartagena, Colombia, September 6-9, 2017.

31) Rodriguez Dominguez A., Resch Y., Zieglmayer P., Valenta R., Vrtala S: Association of IgE profiles to micro-arrayed house dust mite (HDM) allergens with allergic symptoms measured in a house dust mite challenge chamber. Poster presentation. “Together one step further” Joint Symposium MCCA-IAI PhD Programs, Vienna, Austria, September 25-26, 2017.

32) Rodriguez Dominguez A., Resch Y., Zieglmayer P., Valenta R., Vrtala S: Association of IgE profiles to micro-arrayed house dust mite (HDM) allergens with allergic symptoms measured in a house dust mite challenge chamber. Poster presentation., Austria, November 5-7, 2017.

33) Stolz, F., Hochradl M., Babaev, E., Valenta R., Focke-Tejkl M., Kitzmüller C., Bohle B., Wallner M., Ferreira F., Bonu, C., Neubauer A., Development and characterization of a ragweed allergy vaccine based on the peptide carrier principle, Allergy - European Journal of Allergy and Clinical Immunology 2017, 72:144.

34) Weber M., M. Focke-Tejkl, K. Niespodziana, B. Linhart, A. Neubauer, H. Huber, R. Henning, R. Valenta. Comparison of immunogenicity of the recombinant B cell epitope-based grass pollen vaccine BM32 with allergen extract-based SCIT. Allergy - European Journal of Allergy and Clinical Immunology 2017, 72:763

g) Teaching Scripts and Books: n = 0

h) Articles in Medical Journals: n = 0

Performance Report 2017 – Division 3 Immunopathology i) Public activity: n = 86

1) Freidl Raphaela, Raphaela Freidl erhält Förderpreis der Deutschen Gesellschaft für Allergologie und klinische Immunologie, MUW News, https://www.meduniwien.ac.at/web/ueber-uns/news/detailseite/2017/news-im- oktober-2017/raphaela-freidl-erhaelt-foerderpreis-der-deutschen-gesellschaft-fuer- allergologie-und-klinische-immunologie/

2) Lupinek Christian, Heute, “Mit Blutwäsche gegen Allergien“, netdoktor, Nr. 3143, 21.3.2017, S 28-29.

3) Lupinek Christian, Österr. Ärztezeitung, „Allergisches Asthma: IgEnio entfernt IgE- Antikörper“, ÖAZ Nr.6, 25.3.2017, S 22.

4) Lupinek Christian, Valenta Rudolf, APA Science, „Neue Methode entfernt Auslöser für allergisches Asthma: Antikörper werden abgesaugt“, 3.3.2017: http://science.apa.at/medizin_und_biotech/detail.html?key_SCI_20

5) Lupinek Christian, Valenta Rudolf, der Standard.at, Gesundheit, „Absaugmethode entfernt Auslöser für allergisches Asthma“, 3.3.2017: http://derstandard.at/2000053538123/Absaug-Methode-entfernt-Auslöser …

6) Lupinek Christian, Valenta Rudolf, Die Presse, Wissen und Innovation/Medizin, „Nach Antikörpern fischen“, 11.3.2017,S 33

7) Lupinek Christian, Valenta Rudolf, Doktor in Wien, Service/Medizin, „Neue Methode entfernt Auslöser für allergisches Asthma“, Ausgabe 04/2017, S.30

8) Lupinek Christian, Valenta Rudolf, Kleine Zeitung: „MEDUNI WIEN. Neue Methode entfernt Auslöser für allergisches Asthma“ , 3.3.2017: http://www.kleinezeitung.at/oesterreich/5177938/-MedUni-Wien_Neue-Methode- entfernt-Ausloeser-fuer-allergisches-Asthma

9) Lupinek Christian, Valenta Rudolf, Kronen Zeitung, Krone Bunt, Allergie, „Pollenfilter fürs Immunsystem“, 14.5.2017, S.34

10) Lupinek Christian, Valenta Rudolf, Kurier Österreich, „Neue Behandlung bei allergischem Asthma“, 04.04.2017/S. Forschung 4

11) Lupinek Christian, Valenta Rudolf, Kurier.at, „Neue Methode entfernt Auslöser für allergisches Asthma“, 3.3.2017: https://kurier.at/wissen/“neue-methode-entfernt- ausloeser-fuer-allergisches-asthma/249.648.990

12) Lupinek Christian, Valenta Rudolf, medicalexpress.com, „ New technique removes the cause of allergic asthma“, 3.3.2017: https://medicalexpress.com/print407749205.html

13) Lupinek Christian, Valenta Rudolf, medmix.at, „Mit IgEnio IgE-Antikörper entfernen“, 3.3.2017: http://www.medmix.at/igenio-ige-antikoerper-entfernen/#respond

14) Lupinek Christian, Valenta Rudolf, newatlas.com, „New asthma treatment pulls the problem out of the blood“, 3.3.2017: http://newatlas.com/igenio-column- asthma/48245/

Performance Report 2017 – Division 3 Immunopathology

15) Lupinek Christian, Valenta Rudolf, newscaf.com, ““New technique removes the cause of allergic asthma: Antibodies are suctioned off”, 3.3.2017: http://www.newscaf.com/science/new-technique-removes-the-cause-of-...

16) Lupinek Christian, Valenta Rudolf, ÖJ-Österreich-Woche, „Neue Methode entfernt Auslöser für allergisches Asthma“, pdf-Magazin Nr.162, 28.2.2017-06.03.2017: http://www.oe-journal.at/aktuelles/!2017/W4/20303meduniWien.htm

17) Lupinek Christian, Valenta Rudolf, OÖNachrichten, „Hilfe bei Asthma“, 4.3.2017, S.24

18) Lupinek Christian, Valenta Rudolf, Presseaussendung MedUniWien zur Allerg. Asthma vom 3. März 2017: Neue Methode entfernt Auslöser für allergisches Asthma- Antikörper werden abgesaugt . https://www.meduniwien.ac.at/web/presse- meduni-wien/presseaussendungen/

19) Lupinek Christian, Valenta Rudolf, sciencedaily.com, “New technique removes the cause of allergic asthma: Antibodies are suctioned off”, 3.3.2017: https://www.sciencedaily.com/release/2017/170303091520.htm

20) Lupinek Christian, Valenta Rudolf, studium.at, „Neue Methode entfernt Auslöser für allergisches Asthma“, 3.3.2017: http://www.studium.at/536436-neue-methode- entfernt-ausloeser-fuer-al...

21) Lupinek, Christian, Valenta Rudolf, Kleine Zeitung Steiermark und Graz, Forschung, „Neue Therapie bei allergischem Asthma“, 4.3.2017, S.10

22) Lupinek, Christian, Valenta Rudolf, Kurier, Kurier um 4:00, „Neue Therapie gegen allergisches Asthma“, S 3., 3.3.2017

23) Lupinek, Christian, Valenta Rudolf, Kurier, Lebensart, Gesundheit, „Blutwäsche hilft gegen Allergien“, 4.3.2017 S.23

24) Mittermann Irene, 30.06.2017, Die Presse, Sichere Therapie gegen Insektenstichallergie

25) Niespodziana Katarzyna, 10.1.2017 (Krone), "Schnupfenalarm: was jetzt hilft!"

26) Niespodziana Katarzyna, 8.1.2017 (Bild am Sonntag), "Schluss mit Schnief!"

27) Valenta Rudolf , Heute-Aktuell in den Tag, 09.01.2017, S.10,

28) Valenta Rudolf Kurier (Wien), Wissen, „Schnupfenviren mit Impfung austricksen“, 10.01.2017, S.21

29) Valenta Rudolf, “Express.co.uk: common cold cure Breakthrough: how to get rid of a cold Vaccine patented by scientists”, 9.1.2017: https://www.express.co.uk/lifestyle/health/752064/How-to-get-rid-of-cold-cure

30) Valenta Rudolf, „Heilpraxisnet.de: Medizin: Impfstoff gegen Schnupfen entdeckt“, 10.1.2017: http://www.heilpraxisnet.de/naturheilpraxis/medizin-impfstoff-gegen- schnupfen-entdeckt-20170109215357

31) Valenta Rudolf, 20min.ch, „Gesundheit. Österreicher erfindet Impfung gegen Schnupfen2, 9.1.2017: http://www.20min.ch/wissen/gesundheit/story/12390103

Performance Report 2017 – Division 3 Immunopathology

32) Valenta Rudolf, Aboutpharma.com, “Vaccine cor common cold could be available in 6 to 10 Years”, 11.1.2017: https://www.aboutpharma.com/blog/2017/01/11/raffreddore- luniversita-vienna-brevetta-un-vaccino/ 28

33) Valenta Rudolf, Apotheker Krone Fachmagazin für Pharmazeuten, Sonderausgabe Atemwege, Feb.2017: Interview „Österreich hat die Nase vorn“, S.4-5

34) Valenta Rudolf, Augsburger Allgemeine.de, Erkältung. „Ist bald eine Impfung gegen Schnupfen möglich?“, 10.1.2017: http://www.augsburger- allgemeine.de/wissenschaft/Kommt-bald-die-Impfung-gegen-Schnupfen- id40173137.html

35) Valenta Rudolf, Belfast Telegraph 10, “Common cold vaccine 'in reach' and could be available in six to eight years, says Professor Rudolf Valenta”, 10.1.2017: https://www.belfasttelegraph.co.uk/news/health/common-cold-vaccine-in-reach-and- could-be-available-in-six-to-eight-years-says-professor-rudolf-valenta-35356817.html

36) Valenta Rudolf, Bild am Sonntag (BamS), Leben und Gesundheit „Wann kommt endlich die Impfung gegen Erkältung“, Okt. 2017, S. 28

37) Valenta Rudolf, BILD am Sonntag, „Schluss mit Schnief! Professor entwickelt Impfung gegen Schnupfen“, „ Bams trifft den Arzt, der den Schnupfen abschaffen möchte“, 08.01.2017, S.1, 18-19

38) Valenta Rudolf, Bild.de„Wiener Arzt entwickelt Impfstoff. Nie wieder Schnupfen!“, 7.1.2017: http://www.bild.de/bild-plus/news/inland/medizin/nie-wieder-schnupfen- 49643222,view=conversionToLogin.bild.html

39) Valenta Rudolf, Contra-Magazin.com, „Kommt nun die Schnupfenimpfung?“, 9.1.2017: https://www.contra-magazin.com/2017/01/kommt-nun-die-schnupfenimpfung/

40) Valenta Rudolf, DA -Die Apotheke, „Kreuzallergien: Eine kleine Gemeinheit der Natur“, 4/2017, S.30-32

41) Valenta Rudolf, Der Gesundheitsratgeber, Mediaplanet, „Allergie oder Intoleranz- das ist hier die Frage“, Juni 2017, S.3

42) Valenta Rudolf, Der Spiegel, Wissen, „Erkältung. Viren schleudern“, ,Ausgabe 6, 18.12.2017, S.20-25

43) Valenta Rudolf, Der Standard, „Gräserallergie: Das Immunsystem ausbremsen“,20.06.2017, S. 1, 11

44) Valenta Rudolf, der Standard.at, „Gräserallergie: Neue Impfung bremst Immunsystem“, 20.6.2017: https://derstandard.at/2000059466919/Graeser-Allergie- Neue-Impfung-bremst-Immunsystem

45) Valenta Rudolf, Focus Gesundheit , Burda News, „Gesunde Atemwege. Die Neue Therapien. Erkältungen&Grippe“, Mai/Juni, 2017, S.28-32.

46) Valenta Rudolf, Focus online, „Ein Pieks genügt. Erste Tests erfolgreich: Bald sollen Impfungen gegen Schnupfen, Brustkrebs, Alzheimer helfen“, 9.1.2017: http://www.focus.de/gesundheit/ratgeber/krebs/therapie/forschung/impfungen-gegen- schnupfen-brustkrebs-alzheimer_id_6467341.html

Performance Report 2017 – Division 3 Immunopathology

47) Valenta Rudolf, Gesünder leben, „Nahrungsmittelunverträglichkeiten“, Heft 4/2017, April 17, S.19.

48) Valenta Rudolf, heute.at, “Wiener erfindet Impfung gegen Schnupfen”, 9.1., : http://www.heute.at/science/gesundheit/Wiener-erfindet-Impfung-gegen- Schnupfen;art23696,1387083

49) Valenta Rudolf, Independent.co.uk, “Common cold vaccine patent registered”, 10.1.2017: http://www.independent.co.uk/life-style/health-and-families/health- news/common-cold-vaccine-patent-body-fights-disease-wrong-way-rudolf-valenta- vienna-university-a7519171.html

50) Valenta Rudolf, krone.at, „Wiener Ärzte erfinden Impfung gegen Schnupfen“, 8.1.2017: http://www.krone.at/wissen/wiener-aerzte-erfinden-impfung-gegen- schnupfen-patent-angemeldet-story-547674

51) Valenta Rudolf, Kronen Zeitung (Wien Morgenausgabe), „Erste Impfung gegen Schnupfen“, „Ärzte aus Wien erfanden Schnupfen- Impfung ,09.01.2017, S.1, 8-9

52) Valenta Rudolf, Kronen Zeitung „ Neue Impfung und klassische Hausmittel: Was jetzt gegen Schnupfen wirkt“, Im Brennpunkt, „Die Antikörper greifen an der falschen Stelle“, 10.1.2017 S. 12-13

53) Valenta Rudolf, Kurier (Wien) Morgenausgabe, „Allergie oder Intoleranz - das ist hier die Frage“, 14.06.2017, S.Lunge_Allergien3

54) Valenta Rudolf, Kurier um 4:00, Wissen. „Schnupfenviren mit Impfung austricksen“, 09.01.2017S.4

55) Valenta Rudolf, Kurier.at, Wissen, „Schnupfenviren mit Impfung austricksen“, 9.1.2017: https://kurier.at/wissen/schnupfenviren-mit-impfung- austricksen/240.071.386

56) Valenta Rudolf, MDR Aktuell, „Gibt es bald eine Impfung gegen Erkältung?2 im Radio um 6.50 Uhr, 10.01.2017

57) Valenta Rudolf, mdr.de, „Gibt es bald eine Impfung gegen Erkältung?“, 10.1.2017: http://www.mdr.de/wissen/impfung-106.html

58) Valenta Rudolf, Mediaplanet online, Volkskrankheiten, „Allergie oder Intoleranz- das ist hier die Frage“, 06-2017: http://www.volkskrankheiten.at/allergien-und- unvertraeglichkeiten/allergie-oder-intoleranz-das-ist-hier-die-frage

59) Valenta Rudolf, Medical Daily, “Vaccine for common cold could be available in 6 to 10 years”, 12.1.2017: http://www.medicaldaily.com/vaccine-common-cold-could-be- available-6-10-years-408461

60) Valenta Rudolf, Medical Tribune (Österreich), „Milben haben Keime im Gepäck“, Ausgabe 35/2017, 30.8.2017, S.7

61) Valenta Rudolf, medonline.at, „Milben haben Keime im Gepäck“, 30.8.2017: http://webkiosk.medonline.at/medical-tribune-35-2017/59403105/6

62) Valenta Rudolf, MedUniWien website Meldung von 12.12.2017, „Neue Methode zur Vorhersage von Allergien der Atemwege in der frühen Kindheit“:https://www.meduniwien.ac.at/web/ueber-uns/news/detailseite/2017/news-

Performance Report 2017 – Division 3 Immunopathology

im-dezember-2017/neue-methode-zur-vorhersage-von-allergien-der-atemwege-in- der-fruehen-kindheit/

63) Valenta Rudolf, MedUniWien website Meldung von 14.12.2017, „Rudolf Valenta erhält russischen „Mega-Grant“: https://www.meduniwien.ac.at/web/ueber- uns/news/detailseite/2017/news-im-dezember-2017/rudolf-valenta-erhaelt- russischen-mega-grant/

64) Valenta Rudolf, MedUniWien website Meldung von 6.12, „MedUniWien wird WAO Center of Excellence“: https://www.meduniwien.ac.at/web/ueber- uns/news/detailseite/2017/news-im-dezember-2017/meduni-wien-wird-wao-center-of- excellence/

65) Valenta Rudolf, meinbezirk.at, „Nie mehr Schnupfen: Serumerfinder Rudolf Valenta im Interview“,16.01.2017: https://www.meinbezirk.at/hietzing/lokales/nie-mehr- schnupfen-serumerfinder-rudolf-valenta-im-interview- d1989229.html?cp=Kurationsbox

66) Valenta Rudolf, Monopol Medien, Kurier (Wien),“Wieso die Impfkur umstritten ist“, 07.03.2017, S.A4

67) Valenta Rudolf, Neue Post, „Die Pollen kommen. So beugen Sie vor. Durchhalten lohnt sich“, Nr.4, 18.1.2017, S.55

68) Valenta Rudolf, Oe24 Top News 10.00, 11.01.2017, “Impfstoff gegen Schnupfen” Oe24, 10:00

69) Valenta Rudolf, Oe24 Top News, „Den Schupfen durch Impfung verhindern“, 09.01.2017, Oe24, 14:00

70) Valenta Rudolf, Oe24 Top News, „Den Schupfen durch Impfung verhindern“, 09.01.2017, Oe24, 18:00

71) Valenta Rudolf, Österreichisher Impftag 2018, „Impfung gegen Allergien/ Allergievakzine“, Apotheker Krone 21, 2017, S.12

72) Valenta Rudolf, Profil Wissenschaft, „Wir fahren mit dem Reserverad“, Nr.50, 11.12.2017, S 67

73) Valenta Rudolf, Rudolf Valenta erhält russischen „Mega-Grant“, MUW News, https://www.meduniwien.ac.at/web/ueber-uns/news/detailseite/2017/news-im- dezember-2017/rudolf-valenta-erhaelt-russischen-mega-grant.

74) Valenta Rudolf, Sendung Servus TV, 9.1.2017, Schnupfen

75) Valenta Rudolf, Stern, Wissen/Technik, „Medizin: Erziehung zur Abwehr“, 25.1.2017, S.104-105

76) Valenta Rudolf, Stern.de, „Kampf gegen Viren: Lassen sich Erkältungen bald wegimpfen?“, 4.2.2017: https://www.stern.de/gesundheit/grippe/kampf-gegen-viren-- lassen-sich-erkaeltungen-bald-wegimpfen--7310702.html

77) Valenta Rudolf, Welt.de „Die Impfung gegen Husten und Schnupfen“, 9.1.2017: https://www.welt.de/print/die_welt/wissen/article160987400/Die-Impfung-gegen- Husten-und-Schnupfen.html

Performance Report 2017 – Division 3 Immunopathology

78) Valenta Rudolf, Welt.de, „Mit dieser Impfung bleiben Husten und Schnupfen draußen“, 8.1.2017: https://www.welt.de/gesundheit/article160965660/Mit-dieser- Impfung-bleiben-Husten-und-Schnupfen-draussen.html

79) Valenta Rudolf, Wien.at , Club Wien, „Kleiner Stich statt lautem Niesen“, 22.9.2017: https://club.wien.at/magazin/gesundheit/schnupfen-impfung/?L=0

80) Valenta Rudolf, wien.at, Forschen & Entdecken, Allergie-Abwehr aus dem Labor, „Hilfe, wenn der Frühling kommt“, Ausgabe 01/2017, S 6-11

81) Valenta Rudolf, Wiener Bezirkszeitung Innere Stadt, „Nie mehr Schnupfen“, Ausgabe 3, 18/19.01.2017, S.1,6

82) Valenta Rudolf, Wiener Bezirkszeitung Leopoldstadt, „Nie mehr Schnupfen“, Ausgabe 3, 18/19.01.2017,S.1,6

83) Valenta Rudolf, Wiener Bezirkszeitung Margareten, „Nie mehr Schnupfen“, Ausgabe 3, 18/19 01.2017, S.1,6

84) Valenta Rudolf, Wiener Bezirkszeitung Simmering, „Nie mehr Schnupfen“, Ausgabe 3, 18/19.01.2017, S.1,6

85) Valenta Rudolf, Yahoo.de, „Kommt die Impfung gegen Schnupfen?“, 9.1.2017: https://de.nachrichten.yahoo.com/kommt-die-impfung-gegen-schnupfen- 141337302.html

86) Valenta Rudolf, ZME Science, “Common cold vaccine patented in the EU”, 11.1.2017: https://www.zmescience.com/medicine/diseases-medicine/cold-vaccine/

1.3.2. Research Awards: n = 5

1) Campana, Raffaela; Poster Presentation Award, European Academy of Allergy and Clinical Immunology (EAACI), 2017.

2) Dzoro Sheron, poster presentation award, SFB, Work in progress Meeting, Ottenstein, Austria, 5-7.11. 2017.

3) Freidl Raphaela, Förderpreis „Spezifische Immuntherapie“ der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI).

4) Gattinger Pia, poster price, 8th CePII Center Retreat, Vienna, Austria, 19.09.2017.

5) Flicker Sabine, best oral presentation award, Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), 2017.

1.3.3. Invited lectures: n = 47

1) Campana, Raffaela; X World Asthma, Allergy & COPD Congress, „Immunotherapy with the recombinant B cell epitope-derived grass pollen allergy vaccine BM32 induces long-term protection”, „Immune responses in non-allergic subjects vaccinated with recombinant hypoallergenic fragments of the major birch pollen allergen, Bet v 1”, April 28 – May 1, 2017, New York, USA.

Performance Report 2017 – Division 3 Immunopathology

2) Campana, Raffaela; XI World Congress on COPD, Asthma & Immunopathology, „Surrogate markers for measuring the effects of allergen-specific immunotherapy”, „Vaccination with recombinant hypoallergenic allergen derivatives induces a protective allergen-specific IgG responses in non-allergic subjects”, October 5-8, 2017, Moscow, Russia.

3) Flicker, Sabine, Universität München, “Allergen-specific antibodies- from basic findings towards feasible applications”, April 21, 2017, Munich, Germany.

4) Focke-Tejkl Margarete, Pirquet Club, “BM32, ein neuer Impfstoff gegen Gräserpollenallergie”, April 3, 2017, Vienna, Austria.

5) Garib Viktoriya, International conference of immunologists and allergists. “Clinical relevance and management of sensitization to panallergens”, January 12- 13, 2017, Lviv, Ukraine.

6) Garib Viktoriya, Joint Anniversary Session of the Georgian Association of Allergology and Clinical Immunology (GAACI), World Allergy Organization (WAO), World Immunopathology Organization (WIPO), International Association of Asthmology (INTERASMA), European Academy of Allergy and Clinical Immunology (EAACI), American College of Allergy, Asthma and Immunology (ACAAI). “Molecular march of allergy”, July 1, 2017, Tskhaltubo, Georgia.

7) Garib Viktoriya, Moscow Molecular allergy weekend School. “Molecular classification of pollen allergy”, “New criteria of polysensitization”, “Molecular overview of food allergy. Position paper of the EAACI: food allergy due to immunological cross- reactions with common inhalant allergens”, “Why we should use CRD?”, August 25, 2017, Moscow, Russia.

8) Garib Viktoriya, Pediatric conference "Topical Issues and Practical Aspects of Pediatric Pulmonology and Allergy: Standards of Medical Care”, “Molecular Allergy March”, April 6-7, 2017, Kiev, Ukraine.

9) Garib Viktoriya, Regional Scientific-practical conference “Molecular Allergology School”, Institute for post-graduate medical training. “Molecular classification of pollen allergy”, “New criteria of polysensitization”, “Molecular overview of food allergy. Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens”, “Why we should use CRD?”, May 24, 2017, Moscow, Russia.

10) Garib Viktoriya, Regional Scientific-practical training “Molecular Allergology School”, Institute for post-graduate medical training, “Molecular classification of pollen allergy”, “New criteria of polysensitization”, “Molecular overview of food allergy. Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens”, November 20, 2017, Krasnoyarsk, Russia.

11) Garib Viktoriya, Scientific and Practical Conference «Achievements of modern otorhinolaryngology», “Prognostic value of molecular profile of allergic rhinitis”, October 2-3, 2017, Kiev, Ukraine.

12) Garib Viktoriya, Second Conference of Allergists and Immunologists of Ural Region “From molecular diagnostic to allergy treatment and prevention”, “Molecular classification of pollinosis”, “Secrets of successful SIT”, November 18, 2017, Ekaterinburg, Russia.

Performance Report 2017 – Division 3 Immunopathology

13) Garib Viktoriya, Training Symposium Medical University of Vienna & International Network for Molecular Allergology and Immunology in Gomel, “Molecular classification of pollinosis: from different sensitization profiles to different management approaches”, May 12, 2017, Gomel, Belarus.

14) Garib Viktoriya, USHMAI training cource. “Introduction to molecular allergy diagnostic”, March 24, 2017, Skype lecture Vienna for Kiev, Ukraine.

15) Garib Viktoriya, V European Congress on Asthma & CORD, “Most important asthma- associated allergen molecules”. June 30, 2017, Tbilisi, Georgia

16) Garib Viktoriya, XIV Immunology Conference of Ural Region, “Molecular overview of pollen and food allergy”, August 27-29, 2017, Chelyabinsk, Russia.

17) Garib Viktoriya, XIV International Congress “Modern problems of Immunology, allergology and immunopharmacology” RAACI. “Sensitization to pollen panallergens: clinical relevance and management”, March 22-24, 2017, Moscow, Russia.

18) Garib Viktoriya, XVIII Congress of Russian Pediatricians. “From botanical to molecular classification of pollen allergy”, “Molecular diagnosis of food allergy”, February 17-19, 2017, Moscow, Russia.

19) Linhart Birgit, 9. Wiener Komponentenschule, „Rekombinante Allergene“, September 1, 2017, Vienna, Austria.

20) Lupinek Christian, 9. Wiener Komponentenschule, „Molekulare Chipdiagnostik in der pädiatrischen Allergologie“, September 1, 2017, Vienna, Austria.

21) Niespodziana, Katarzyna; XI World Congress on COPD, Asthma & Immunopathology, “Risk factors for wheezing in preschool children: role of rhinovirus and allergen exposure”, “Rhinovirus diagnosis by blood testing with the “PreDicta” chip”, October 5 - 8, 2017 Moscow, Russia.

22) Valenta Rudolf, 10th Federation of African Immunological Societies (FAIS) Congress, ”Towards prophylactic vaccination of allergy: When, how and whom”, December 3-7, 2017, Hammamet, Tunis.

23) Valenta Rudolf, 24th National Congress of Allergy and Clinical Immunology”, “The uses of component-resolved diagnosis in allergy or Molecular allergy diagnosis: Towards preventive medical examination”, “Scientific paper writing: A guide for publishing papers”, November 18-22, 2017, Antalya, Turkey.

24) Valenta Rudolf, 2nd Conference of Allergists and Immunologists of Ural Region, “From pathomechanisms to diagnosis of allergy”, “New strategies for therapy and prevention of allergy”, November 18, 2017, Yekaterinburg, Russia.

25) Valenta Rudolf, 47th Annual Meeting of the German Society for Immunology, “Factors determining the allergenic activity of an antigen”, September 12-15, 2017, Erlangen, Germany.

26) Valenta Rudolf, 7th International Symposium on Molecular Allergology, EAACI-ISMA 2017, “The future of allergen-specific immunotherapy: Molecular approaches”, November 9-11, 2017, Luxembourg.

Performance Report 2017 – Division 3 Immunopathology

27) Valenta Rudolf, 9. Wiener Komponentenschule, “Pathomechanismen der Allergie“, „Mechanismen der spezifischen Immuntherapie (SIT)“, September 1-2, 2017, Vienna, Austria.

28) Valenta Rudolf, AMA Milchsymposium 2017, “Milchunverträglichkeiten – welche Milchalternativen für wen?”, May 31, Vienna, Austria.

29) Valenta Rudolf, EAACI Congress 2017, “Structural and biological evidence for good and bad allergens”, June 17-21, 2017, Helsinki, Finland.

30) Valenta Rudolf, First Medical State University Sechenov, “Key to success in Science”, “Molecular allergology: from diagnosis to treatment of allergy”, September 19-20, Moscow, Russia.

31) Valenta Rudolf, FOCIS European Advanced Course in Basic and Clinical Immunology, “Allergy, molecular diagnostic and allergen Immunotherapy”, October 16-18, 2017, Prague, Czech Republic.

32) Valenta Rudolf, II International Congress “Innovative Technologies in Immunology & Allergy”, “Factors determining the allergenic activity of an antigen”, “Towards preventive medical examination for allergy”, May 17-19, 2017, Russian Academy of Sciences, Moscow, Russia.

33) Valenta Rudolf, Insight to plant biology in modern era. An international symposium for centenary celebration of Bose Institute (1917-2017). “Allergy to plants: From pathomechanisms to diagnosis, therapy and prevention”, February 8-10, 2017, Kolkata, India.

34) Valenta Rudolf, International Advisory Board Meeting Sechenov University Moscow. "Molecular allergology: From diagnosis to prediction to treatment and prevention of allergy", April 5-7, 2017, Moscow, Russia.

35) Valenta Rudolf, Inunimai Training Symposium Medical University of Vienna & International Network for Molecular Allergology and Immunology, “From modern allergy diagnostics to prediction of allergy”, May 12, 2017, Gomel, Republic of Belarus.

36) Valenta Rudolf, IX Georgian National Congress on Allergy, Asthma & Immunology, "From modern allergy diagnosis to prediction of allergy", June 28-July 1, 2017, Tbilisi, Georgia.

37) Valenta Rudolf, MRC & Asthma UK Centre Science Afternoon, “Towards prophylactic vaccination of allergy: When, how and whom”, December 12, 2017, London, United Kingdom.

38) Valenta Rudolf, RAACI Forum, Training Symposium Medical University of Vienna & International Network for Molecular Allergology and Immunology/ XIV International congress ‘Modern problems of Immunology, Allergology and Immunopharmacology’. “From modern allergy diagnosis to prediction of allergy”, March 23, 2017, Moscow, Russia.

39) Valenta Rudolf, Regional Scientific-practical conference “Molecular Allergology School”, Institute for post-graduate medical training. “Diagnostics and specific immunotherapy of food allergy”, “From therapy of allergy to prophylactic vaccination”, “From diagnosis in childhood to allergy prognosis”, February 1, 2017, Khabarovsk, Russia. 95

Performance Report 2017 – Division 3 Immunopathology

40) Valenta Rudolf, Seminar Philipps University Marburg, “Towards allergen-specific approaches for allergy prevention”, June 12, 2017, Marburg, Germany.

41) Valenta Rudolf, The 29th National Conference of the Romanian Physiology Society with international attendance: Personalized Physiology from Concept to Precision Medicine, “Towards preventive medical examination in allergy”, “Factors determining the allergenic activity of an allergen”, “Innovative therapeutic approaches in allergic diseases”, May 25-26, 2017, Timisoara, Romania.

42) Valenta Rudolf, The XVII-th International National Scientific Congress “Asthma and Allergy”. “Molecular allergology: From diagnosis to treatment, prediction and prevention of allergy”, April 25-26, 2017, Almaty, Kazakhstan.

43) Valenta Rudolf, Vladivostok Allergy Conference, “Pathomechanisms and diagnosis of allergic diseases”, “Molecular diagnosis of food allergy”, “New strategies of allergy therapy and prevention”, February 2, 2017, Vladivostok, Russia.

44) Valenta Rudolf, X World Asthma, Allergy & COPD Forum. “Clemens von Pirquet Keynote Lecture: Towards preventive medical examination for allergy”, “Clinical results obtained with the recombinant grass pollen allergy vaccine BM32”, April 28 – May 1, 2017, New York, USA.

45) Valenta Rudolf, XI National Congress of the Italian Society of Immunology, Clinical Immunology and and Allergology, “Immunological mechanisms and clinical efficacy of the recombinant B cell epitope-based grass pollen allergy vaccine BM32”, May 28-31, 2017, Bari, Italy.

46) Valenta Rudolf, XI World Congress on COPD, Asthma and Immunopathology, “Pathomechanisms in allergy”, “Maternal allergen-specific IgG may protect children from allergic sensitization”, October 5-8, 2017, Moscow, Russia.

47) Vrtala Susanne, WAO Symposium “Mite Allergy: From Basics to Clinical Applications”. Mite reagents for immunotherapy: From bench to clinic” September 6-9, 2017, Cartagena de Indias, Colombia.

1.3.4. Congress organization

Division National congress Intern. Congress, member Name: Name, date Function Name, date Function Valenta Rudolf 5th SFB F46 Work in Progress Meeting, Organizer Nov. 5-7, 2017, Ottenstein, Austria Valenta Rudolf Interdisziplinärer Wiener Allergietag, Organizer 10.Mai, 2017, Vienna, Austria Valenta Rudolf 9. Wiener Co- Komponentenschule Organizer Organizer 1.-2.9.2017, Vienna, Austria

Performance Report 2017 – Division 3 Immunopathology

Division National congress Intern. Congress, member Name: Name, date Function Name, date Function Garib Viktoriya Co- USHMAI training Organizer course. “Introduction to molecular allergy diagnostic, level 1”, Kiev, Ukraine, March 24, 2017 Garib Viktoriya Co- Training Symposium Organizer Medical University of Vienna & International Network for Molecular Allergology and Immunology in Gomel, Belarus, May 12, 2017 Garib Viktoriya Co- Regional Scientific- Organizer practical conference “Molecular Allergology School”, Institute for post-graduate medical training. Moscow, Russia, May 24, 2017. Garib Viktoriya Co- Moscow Molecular Organizer allergy weekend School. August, 25, 2017 Garib Viktoriya Co- Second Conference of Organizer Allergists and Immunologists of Ural Region, Ekaterinburg, Russia, November 18, 2017. Garib Viktoriya Co- Regional Scientific- Organizer practical training “Molecular Allergology School”, Krasnoyarsk, Russia, November 20, 2017.

1.3.5. Hosting speakers

division member Speaker´s name Affiliation Date Valenta Rudolf Leyla Namazova, Prof. in Pediatrics, Prof. in March 17 , 2017 Prof. MD, Phd Allergy/Immunology, Scientific Centre of Children Health, Vice-director President of the Russian Union of Pediatricians, Academician of Russian Academy of Medical Sciences Moscow, President of the European Pediatric Association (EPA/UNEPSA)

Performance Report 2017 – Division 3 Immunopathology

Valenta Rudolf Faith Osier, Prof. Clinical Research Fellow and Group April 11, 2017 Leader, Kenya Medical Research Inst., Centre for Geographic Medicine Research, Coast (KEMRI-CGMRC), Centre for Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Visiting Professor of Malaria Immunology, Nuffield Department of Medicine, University of Oxford, UK Valenta Rudolf Elopy N. Sibanda, Asthma, Allergy and Immune April 11, 2017 Prof. Dysfunction Clinic, Parirenyatwa University Teaching Hospital, Zimbabwe, The National Univ. of Science and Technology Medical School, Zimbabwe, Adjunct Professor, Medical University of Vienna, Austria Valenta Rudolf Hans C. Oettgen, Children's Hospital Professor of April 18, 2017 Prof., MD, PhD, Pediatric Immunology, Harvard Medical School, Associate Chief, Division of Immunology, Boston Children’s Hospital Valenta Rudolf Duc H. LE, PhD UK Editor-in-Chief, EBioMedicine, June 7, 2017 London, UK Valenta Rudolf Sergey Tillib, PhD Head of Lab , Institute of Gene July 13, 2017 Biology, Russian Academy of Sciences, Moscow, Russia Valenta Rudolf Stephen Durham, Professor of Allergy and Respiratory July 28, 2017 Prof. Medicine, Inflammation, Development & Repair, National Heart & Lung Institute, Faculty of Medicine, Imperial College London, UK Valenta Rudolf Trevor Hansel, Medical Director of Imperial Clinical July 28, 2017 BSc, MBBCh, MSc, Respiratory Research Unit (ICRRU), FRCPath, PhD Reader in Respiratory Clinical Pharmacology, Honorary Consultant Immunologist, St Mary's Hospital, London, UK Valenta Rudolf Chrysanthi Skevaki, Institute of Laboratory Medicine and August 11, 2017 MD, PhD Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, University Hospital Giessen and Marburg GmbH, Marburg, Germany Valenta Rudolf Allen P. Kaplan, Nat. Allergy, Asthma and Uriticaria October 4, 2017 Prof. MD Centers of Charleston, Med. Univ. of South Carolina, USA Valenta Rudolf Allen P. Kaplan, Nat. Allergy, Asthma and Uriticaria October 9, 2017 Prof. MD Centers of Charleston, Med. Univ. of South Carolina, USA Valenta Rudolf Thomas Platts- Director, Div. of Allergy and Clin. October 9, 2017 Mills, Prof. MD, Immunology, Univ. of Virginia School PhD of Medicine, Charlottesville, VA, USA Valenta Rudolf Susetta Finotto, Universitätsklinikum Erlangen November 10, Prof. Dr. Dr. Abt. Molekulare Pneumologie 2017 Erlangen, Germany

Performance Report 2017 – Division 3 Immunopathology

Valenta Rudolf Christian Radauer, MedUni Wien, Abteilung für September 1, Dr. Medizinische Biotechnologie, Institut 2017 für Pathophysiologie und Allergieforschung Valenta Rudolf Christine Hafner Universitätsklinikum St.Pölten, September 1, Dz. Dr. Abteilung für Haut und 2017 Geschlechtskrankheiten Valenta Rudolf Stefan Wöhrl Doz. Floridsdorfer Allergiezentrum September 1, Mag. Dr. 2017 Valenta Rudolf Zsolt Szepfalusi MedUni Wien Abteilung für Kinder- September 1, Univ.Prof. Dr. und Jugendheilkunde 2017 Valenta Rudolf Werner Aberer Meduni Graz, Universitätsklinik für September 1-2, Prof. Dermatologie und Venerologie 2017 Valenta Rudolf Julia Eckl-Dorna MedUni Wien, Christian Doppler September 2, DDr. Labor für Allergie- 2017 forschung, Abteilung für Immunpathologie, Institut für Pathophysiologie und Allergieforschung Valenta Rudolf Katharina Marth Dr. Krankenhaus Hietzing, Abteilung für September 2, Lungenheilkunde 2017 Valenta Rudolf Petra Zieglmayer Thermo Fisher Diagnostics Austria September 2, Dr. GmbH, Fachärztin für HNO 2017 Valenta Rudolf Roland Buhl Mainz, Germany May 10, 2017 Valenta Rudolf Sven Becker Mainz, Germany May 10, 2017 Valenta Rudolf Joachim Saloga Mainz, Germany May 10, 2017 Valenta Rudolf Detlef Schuppan Mainz, Germany, Harvard USA May 10, 2017 Valenta Rudolf Barbara Bohle MedUni Wien, Institut für May 10, 2017 Pathophysiologie und Allergieforschung Valenta Rudolf Winfried Pickl MedUni Wien, Institut für May 10, 2017 Immunologie Valenta Rudolf Erika Jensen- MedUni Wien, Institut für May 10, 2017 Jarolim Pathophysiologie und Allergieforschung Valenta Rudolf Zsolt Szepfalusi MedUni Wien, Universitätsklinik für May 10, 2017 Kinder- und Jugendheilkunde

1.3.6. Mobility

Name Program University, Time frame Division In Out Country David Tvildiani Abulashvili 04.09.2017 – Dissertantin Med.Univ., Tbilisi, 3 X Nutsa 13.10.2017 Georgia Bachmayr 14.11.2017- Praktikantin 3 X Victoria 22.12.2017 Karolinska Borochova 29.5.2017 – IAI PhD Program Institutet, 3 X Kristina 4.9.2017 Stockholm, Sweden 16.10.2017 – Castea Julia Praktikantin 3 X 24.11.2017 Dorofeeva MCCA Hospital Infanta 3 X Yulia Leonor, Madrid, Spain Bundesrealgymnasi Berufspraktische 30.1.2017 – Gebel Julia um “Bertha von 3 X Tage 1.2.2017 Suttner”

Performance Report 2017 – Division 3 Immunopathology

Name Program University, Time frame Division In Out Country 25.1.2017 – Ivanov Daniel Praktikant 3 X 31.1.2017 Medical University of Vienna, Institute 2.11.2017 – Linhart Birgit of Pathophysiology 3 X 23.12.2017 and Allergy Research Lorraine Univ. of Zimbabwe, 07.11.2017 – 3 X Pfafayi Harare, Zimbabwe 31.1.2018 Sechenov 08.11.2017 Marina Manina Dissertantin University, 3 X 30.11.2017 Moscow, Russia State Univ. North Pacheco 13.06.2017 – Dissertantin Fulminense, Rio de 3 X Soares Thais 27.10.2017 Janeiro, Brazil 4.9.2017 – Quell Laura Praktikantin 3 X 5.11.2017 Rodriguez- Dissertantin AG Molekulare 21.6.2017- 3 x Dominguez Allergologie und 23.9. 2017 Azahara Immunmodulation, Klinik für Pädiatrie m.S. Pneumologie und Immunologie, Charité Universitätsmedizin Berlin Sasani Nadia Beobachterin 2.1.2017 – 3 X 31.1.2017 Sidorova Inna Beobachterin Sechenov 20.01.2017 – 3 X University, 20.3.2017 Moscow, Russia Skalvy Laure Praktikantin 9.10.2017 – 3 X 23.11.2017 Snovskaya Beobachterin Fed. State 23.10.2017 – 3 X Marina Autonomous Inst., 12.11.2017 "Nat. Scientific and Practical Center of childrens Health", Moscow, Russia Susetta UK Erlangen, Dt. 2.10. 2017 – 3 X Finotto 4.10.2017 8.11. 2017 – 10.11.2017 Weichwald Praktikantin 28.8.2017 – 3 X Christina 22.9.2017

1.3.7. Activities in Advisory Boards

Name Society/Institute/Journal Function

100

Performance Report 2017 – Division 3 Immunopathology

1.3.8. Editorial Activities

Name Journal Function Valenta Rudolf International Archives of Allergy Editor in Chief and Immunology Valenta Rudolf International Archives of Allergy Editorial Board and Immunology Valenta Rudolf ACI International Editorial Board Valenta Rudolf Allergo Journal Editorial Board Valenta Rudolf Journal of Investigational Editorial Board Allergology & Clinical Immunology Valenta Rudolf European Journal of Clinical Editorial Board Investigation Valenta Rudolf Calcium Binding Proteins Editorial Board Valenta Rudolf International Journal of Editorial Board Immunorehabilitation Valenta Rudolf American Journal of Plant Editorial Board Sciences Valenta Rudolf Revista Alergia Mexico Editorial Board Valenta Rudolf Clinical Reviews in Allergy and Editorial Board Immunology Valenta Rudolf American Journal of Clinical and Editorial Board Experimental Immunology Valenta Rudolf Archives of Pediatric Infectious Editorial Board Diseases Garib Viktoriya International Journal of Editorial Board Biomedicine Garib Viktoriya International Archive Allergy and Invited Editor Immunology (Russian supplement)

1.3.9. Review Activities

Name Grants/Thesis/Habilitation Susanne Vrtala Hr. Xinyuan Huang, Thesis, Evolution of serum IgE and IgG antibodies to 35 molecules in childhood

1.3.10. Filed and granted patents

Name Patent Patent No. Filed Granted FLICKER, Sabine VALENTA, Rudolf Antibody Construct EP3256489 20.12.2017 Valenta Bi-specific antibody conjugates Rudolf ICAM1/allergen US2018022308 10.08.2017 Valenta Rudolf Fusion Protein WO2017037280 9.3.2017 101

Performance Report 2017 – Division 3 Immunopathology

Name Patent Patent No. Filed Granted Valenta Fusion protein for use in the Rudolf treatment of a hepatitis B virus infection EP3138579 8.3.2017 Valenta Hausstaubmilbenallergen Milbe Rudolf der P 23 JP6105520 29.03.2017 Valenta Hepatitis B Vakzine (Fusion Rudolf protein) CA2997511 09.03.2017 Valenta Rudolf House dust mite allergen 20170218034 3.8.2017 Valenta Method for diagnosing a Rudolf rhinovirus infection 2.5.2017 Valenta Method for diagnosing a viral Rudolf infection ZA201507116 26.07.2017 Valenta Rudolf Novel Wheat allergens DK2225266 07.08.2017 Valenta Rudolf Novel Wheat allergens ES2634241 27.09.2017 Valenta Rudolf Novel Wheat allergens EP2225266 19.04.2017 Valenta Rudolf Novel Wheat allergens CA2707190 02.01.2018 Valenta Nutritional Formulation Rudolf comprising a cow's milk peptide- containing hydrolysate and/or peptides derived thereof for tolerance induction MY 161010 (A) 31.03.2017 Valenta Nutritional Formulation Rudolf comprising a cow's milk peptide- containing hydrolysate and/or peptides derived thereof for tolerance induction TWI584736 01.06.2017 Valenta Peptide Carrier fusion proteins as Rudolf Allergy Vaccines-Hepatitis B US 14.701.848 19.12.2017 Valenta Peptide Carrier fusion proteins as Rudolf Allergy Vaccines-Hepatitis B CN201280028169.7 15.09.2017 Valenta Peptide Carrier fusion proteins as Rudolf Allergy Vaccines-Hepatitis B RU 2013157115 11.09.2017 Valenta Peptide Carrier fusion proteins as Rudolf Allergy Vaccines-Hepatitis B JP 2014514111 26.07.2017 Valenta Peptide Carrier fusion proteins as Rudolf Allergy Vaccines-Hepatitis B AU2012266246 11.05.2017

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1.3.11. Grants

Funding agency Title of project Principal investigator Biomay Produktions-und Impfstoffe und Toleranzstrategien für Rudolf Valenta Handels-Aktiengesellschaft Typ I Alllergie. (RV), AP00085OFF VIRAVAXX AG Forschung zur Entwicklung von aktiven Rudolf Valenta FA648A0306 und passiven Impfstoffen basierend auf der Peptid/Carrier-Technologie zur spezifischen Therapie und Prävention von viralen Erkrankungen Fresenius Medical Care POIA - Characterization of the IgE Rudolf Valenta Germanyy GmbH binding properties of Immunoadsorbers FA648A0307 Biomay Produktions-und MONITOR - Bestimmung der Rudolf Valenta Handels-Aktiengesellschaft blockierenden Eigenschaften von FA648A0308 Antikörpern gegen Allergene Karger Verlag, Editorial Office, Personalkosten, Rudolf Valenta UE64801005 Sachkosten. Fonds zur Förderung PHD-Program „Inflammation and Rudolf Valenta Wissenschaftlicher Immunity“. Forschung (FWF) MUW PHD-Program „Inflammation and Rudolf Valenta Immunity“, Rudolf Valenta Fonds zur Förderung PhD-Program Molecular, Cellular and Rudolf Valenta Wissenschaftlicher Clinical Allergology, MCCA. Forschung (FWF) Fonds zur Förderung PhD-Program Molecular, Cellular and Susanne Vrtala Wissenschaftlicher Clinical Allergology, MCCA. Forschung (FWF) Fonds zur Förderung PhD-Program Molecular, Cellular and Margarete Focke-Tejkl Wissenschaftlicher Clinical Allergology, MCCA. Forschung (FWF) FWF-SFB F4601-B19, Coordination project, „Towards Rudolf Valenta APF04601FW prevention and therapy of allergy“ Rudolf Valenta FWF-SFB F4605-B19, “Towards prophylactic vaccination of Rudolf Valenta APF04605FW allergy”. FWF-SFB F4601-B19, Infrastructure for SFB Rudolf Valenta APF04601FW Infrastructure for SFB by Medical University of Vienna FWF-SFB F4602-B19, “Strategies for diagnosis, treatment and Susanne Vrtala APF04602FW prevention of house dust mite allergy “. FWF-SFB F4607-B19, Allergen specific antibodies for therapy Sabine Flicker APF04607FW and prevention of allergy. European Research Towards safe and effective Birgit Linhart Grant - FP7 – Seventh immunotherapy of persistent life- Framework, threatening food allergies. FA648A1101 Bundesministerium für Towards safe and effective Birgit Linhart Wissenschaft und immunotherapy of persistent life- Forschung, EU threatening food allergies. Zusatzfinanzierung für 7. Rahmenprogramm, FA648A1102 FWF, P29398-B30 High resolution mapping of human Katarzyna Niespodziana rhinovirus-specific antibody responses

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FWF, P26728-820, Towards new forms of safe Irene Mittermann APP26728FW immunotherapy for insect allergy. FWF, P 29991-B30 Characterization of the allergic Margarete Focke-Tejkl structures in Oleaceae pollen. KO64800001 Kongresskonto Interdisziplinärer Wiener Rudolf Valenta Allergietag KO648D0001 Kongresskonto INUNIMAI Rudolf Valenta Acteria ACTERIA Dissertationspreis Sandra Wieser Dissertationspreis 2015, European Federation of Immunological Societies

1.3.12. Career Developments a) Habilitations: n = 0

b) Habilitations in progress: n = 0

c) Professorships: n = 0

1.3.13. Teaching a) Bachelor students: n = 0

b) Diploma, MDiploma and Master students: n = 2 1. Ivanov Daniel, Master thesis: Reversion of a birch pollen allergen,Bet v 1-specific human IgG-derived ScFv into germline configuration (2/2017 – in progress). 2. Sarzsinszky Eszter, Master thesis: "Production and purification of recombinant Blomia tropicalis and Dermatophagoides pteronyssinus allergens from Escherichia coli culture" (11/2017 – in progress).

c) PhD, MDSci, MD students: n = 12 1. Adebanke Oluwatoyin Akinfenwa: PhD thesis: T-cell epitope based oral tolerance induction (11/2017 – in progress). 2. Borochova Kristina: PhD thesis: Immune recognition of RSV antigens and epitopes (10/2014 – in progress). 3. Dorofeeva Yulia: PhD thesis: Peptide-carrier vaccines for the treatment of allergy to Parietaria pollen (10/2014 – in progress). 4. Dzoro Sheron: PhD student: “Characterisation of antibody reactive microbial antigens”, (2013 – in progress). 5. Freidl Raphaela: PhD thesis: Novel approaches for allergen-specific immunotherapy (2/2014 – in progress). 6. Gattinger Pia: PhD thesis: Biological role of IgE-reactive carbohydrates (10/2014 – in progress).

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7. Huang Huey-Jy: PhD thesis: Identification of the dominant T cell and B cell epitopes of important HDM allergens (10/2013 – in progress). 8. Kodydek Mary: PhD thesis: Identification of peptides from the major peanut allergens for the induction of allergen-specific protective IgG antibodies with diminished IgE or T-cell reactivity (10/2013 – in progress). 9. Nazanin Najafi: PhD thesis: IgE dependent activation of effector cells (2012 - in progress). 10. Pazderova Petra: PhD thesis: Development of serological assays for rhinovirus infections: towards a rhinovirus vaccine (9/2017 – in progress). 11. Rodriguez Dominguez Azahara: PhD thesis: Characterization of house dust mite allergens (10/2014 – in progress). 12. Tulaeva Inna: PhD thesis, Characterization of the immune response towards Hepatitis B Virus antigens and epitopes (9/2017 – in progress).

1.3.14. Exams: n = 3 a) examinations: n = 2

1. Valenta Rudolf: 28.6.2017 Molekulare Medizin 2 (5 Pers.) 2. Valenta Rudolf: 15.11.2017 Molekulare Medizin 2 (13 Pers.)

b) Diploma and Thesis-Examinations: n = 0

c) Exam supervising: n = 1 1. Susanne Vrtala: Prüfungsaufsicht: 29.6.2017

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1.3.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2017 Campana Raffaela 2.00 1.00 861005 MCCA Lecture, Thesis Seminar and Basic Course Series on Therapy of Allergy -Novel Routes for Allergen Immunotherapy Flicker Sabine 1.00 0.25 850022 TS: Stimulating Friday Seminar Focke-Tejkl Margarete 2.00 0.13 861007 MCCA Journal Club Focke-Tejkl Margarete 5.00 1.00 648026 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.) Focke-Tejkl Margarete 4.00 1.00 648033 Wissensschaftliches Arbeiten Niespodziana Katarzyna 2.00 1.00 861004 MCCA Lecture, Thesis Seminar and Basic Course Series on Data Visualisation Tools Niespodziana Katarzyna 3.00 0.21 896032 Basics in Gender Medicine Valenta Rudolf 5.00 2.00 648026 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.) Valenta Rudolf 4.00 1.00 648033 Wissensschaftliches Arbeiten Valenta Rudolf 2.00 0.20 860007 Special Course: Scientific Presentation Valenta Rudolf 2.00 0.17 860201 IAI-Journal Club Valenta Rudolf 2.00 0.13 860220 Basisvorlesung Immunologie Valenta Rudolf 2.00 0.13 861007 MCCA Journal Club Valenta Rudolf 2.00 0.20 860202 Special Course: Basic techniques in molecular and cellular biology Valenta Rudolf 2.00 0.15 901929 IAI-Basic Seminars Valenta Rudolf 2.00 2.00 901931 Special Course: Advanced Molecular cloning techniques Valenta Rudolf 2.00 1.00 901941 Special Course: Allergology Valenta Rudolf 2.00 2.00 648024 Journal Club und Progress Report Vrtala Susanne 2.00 0.13 861007 MCCA Journal Club Sum 13.70

WS 2017/18 Campana Raffaela 2.00 2.00 803009 Problemorientiertes Lernen - 3. Semester Flicker Sabine 1.00 0.25 850029 TS: Stimulating Friday Seminar Flicker Sabine 2.00 0.40 860027 TS B cells and antibodies Focke-Tejkl Margarete 5.00 1.00 514034 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.) Focke-Tejkl Margarete 2.00 0.13 861007 MCCA Journal Club

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Focke-Tejkl Margarete 2.00 0.22 861110 MCCA Lecture, Thesis Seminar and Basic Course Series on Allergens Focke-Tejkl Margarete 4.00 1.30 648002 Wissensschaftliches Arbeiten Focke-Tejkl Margarete 2.00 0.66 648005 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie Lupinek Christian 1.13 0.27 801001 BL 1 - Gesunde und kranke Menschen Lupinek Christian 1.00 1.00 801011 Problemorientiertes Lernen - 1. Semester Lupinek Christian 2.20 0.27 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Mittermann Irene 2.00 0.40 860027 TS B cells and antibodies Niespodziana Katarzyna 2.20 0.53 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Resch-Marat Yvonne 2.20 0.27 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Valenta Rudolf 5.00 2.00 514034 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.) Valenta Rudolf 2.00 2.00 648001 Journal Club and Progress Report Valenta Rudolf 4.00 1.30 648002 Wissensschaftliches Arbeiten Valenta Rudolf 2.00 0.66 648005 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie Valenta Rudolf 5.80 0.40 803002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Valenta Rudolf 3.00 0.39 840052 Medizinisches Propädeutikum Teil 1 Valenta Rudolf 2.00 0.18 860008 Special Course: Scientific Presentation Valenta Rudolf 2.00 0.13 861007 MCCA Journal Club Valenta Rudolf 2.00 0.22 861110 MCCA Lecture, Thesis Seminar and Basic Course Series on Allergens Valenta Rudolf 2.00 0.18 870011 Medical Propedeutics ¿ Linking Biology and Diseases - WS 2016/17 Valenta Rudolf 2.00 0.13 901929 IAI-Basic Seminars Valenta Rudolf 2.00 2.00 901931 Special Course: Advanced Molecular cloning techniques Valenta Rudolf 2.00 0.17 902241 IAI-Journal Club Valenta Rudolf 2.00 0.18 902920 Special Course: Basic techniques in molecular and cellular biology Vrtala Susanne 5.00 1.00 514034 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.) Vrtala Susanne 1.13 0.27 801001 BL 1 - Gesunde und kranke Menschen Vrtala Susanne 1.00 1.00 801011 Problemorientiertes Lernen - 1. Semester Vrtala Susanne 2.00 0.13 861007 MCCA Journal Club Vrtala Susanne 2.00 0.66 648005 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie Vrtala Susanne 2.00 0.44 861110 MCCA Lecture, Thesis Seminar and Basic Course Series on Allergens Vrtala Susanne 4.00 1.30 648002 Wissensschaftliches Arbeiten Sum 23.44 Total sum SS+WS 37.14

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1.4. Division of Medical Biotechnology Head: Heimo Breiteneder, Professor

1. Publications7 IF Number Top/Std/Subst Heimo Breiteneder 9.652 6 2 Top, 2 Std, 0 Sstd Karin Hoffmann-S. 20.838 6 2 Top, 2 Std, 0 Sstd Christian Radauer 2.720 1 0 Top, 1 Std, 0 Sstd Division-Sum 33.210 13 4 Top, 5 Std, 0 Sstd Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2

2. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Heimo Breiteneder 0 0 5 Merima Bublin 0 1 0 Karin Hoffmann-S. 0 2 2 Christian Radauer 1 0 0 Sum 1 3 7

3. Teaching SS* WS* total W+S oral Exams Heimo Breiteneder 3.80 3.57 7.37 0 Merima Bublin 1.50 1.53 3.03 0 Geiselhart Sabine 0.27 0.27 0 Karin Hoffmann-S. 0.13 1.88 2.01 0 Christian Radauer 1.00 2.53 3.53 0 Sum 6.43 9.78 16.21 0

7 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications.

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1.4.1. Publications a) Peer-reviewed original articles: n = 4

Nr. Article IF Class pro-rata IF 1. Ebrahimifard R, van den Driesche SG, Breiteneder H, 5.401 Top 1.080 Hafner C, Vellekoop MJ. An infrared sensor system for the analysis and differentiation of living mammalian cells using D20 based microfluidics. Sens Actuator B-Chem. 2017; 247:981-991. doi: 10.1016/j.snb2017.03.057 2. Anzengruber J*, Bublin M*, Bönisch E, Janesch B, 3.236 Std 3.236 Tscheppe A, Braun ML, Varga EM, Hafner C, Breiteneder H, Schäffer C. Lactobacillus buchneri S-layer as carrier for an Ara h 2-derived peptide for peanut allergen-specific immunotherapy. Mol Immunol. 2017; 85:81-88. doi: 10.1016/j.molimm.2017.02.005 3. Dubiela PJ, Aina R, Polak D, Geiselhart S, Humeniuk P, 13.081 Top 13.081 Bohle B, Alessandri S, Del Conte R, Cantini F, Borowski T, Bublin M, Hoffmann-Sommergruber K. Enhanced Pru p 3 IgE-binding activity by selective free fatty acid-interaction. J Allergy Clin Immunol. 2017; 140:1728-1731. doi: 10.1016/j.jaci.2017.06.016 4. Selb R, Eckl-Dorna J, Twaroch T, Lupinek C, Teufelberger A, 13.081 Top 2.616 Hofer G, Focke-Tejkl M, Gepp B, Linhart B, Breiteneder H, Ellinger A, Keller W, Roux K H, Valenta R, Niederberger- Leppin V. Critical and direct involvement of the CD23 stalk region in IgE binding. J Allergy Clin Immunol. 2017; 139:281- 289. doi: 10.1016/j.jaci.2016.04.015 sum 34.799 20.013

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Nr. Article IF Class pro-rata IF 1. Selb R, Wal JM, Moreno FJ, Lovik M, Mills C, Hoffmann- 3.778 Top 0.756 Sommergruber K, Fernandez A. Assessment of endogenous allergenicity of genetically modified plants exemplified by soybean – Where do we stand? Food Chem Toxicol. 2017; 101:139-148. doi: 10.1016/j.fct.2017.01.014 2. Humeniuk P, Dubiela PJ, Hoffmann-Sommergruber K. 3.226 Std 3.226 Dendritic cells and Their Role in Allergy: Uptake, Proteolytic Processing and Presentation of Allergens. Int J Mol Sci. 2017; 18:1491; doi: 10.3390/ijms18071491 3. Mastrorilli C, Caffarelli C, Hoffmann-Sommergruber K. 3.775 Std 3.775 Food allergy and atopic dermatitis: Prediction, progression, and prevention. Pediatr Allergy Immunol. 2017;2 8:831-840. doi: 10.1111/pai.12831 4. Radauer C. Navigating through the Jungle of Allergens: 2.720 Std 2.720 Features and Applications of Allergen Databases. Int Arch Allergy Immunol. 2017; 173: 1-11; doi: 10.1159/000471806 5. Tscheppe A, Breiteneder H. Recombinant Allergens in 2.720 Std 2.720 Structural Biology, Diagnosis and Immunotherapy. Int Arch Allergy Immunol. 2017;172:187-202. doi: 10.1159/000464104 sum 16.219 13.197

c) Invited Articles & Reviews without IF: n = 2

1. Naegeli H, Birch AN, Casacuberta J, De Schrijver A, Gralak MA, Guerche P, Jones H, Manachini B, Messéan A, Nielsen EE, Nogué F, Robaglia C, Rostoks N, Sweet J, Tebbe C, Visioli F, Wal J-M, Eigenmann P, Epstein M, Hoffmann-Sommergruber K, Koning F, Lovik M, Mills C, Moreno FJ, van Loveren H, Selb R, Dumont AF. EFSA Panel on Genetically Modified Organisms (GMO): Guidance on allergenicity assessment of genetically modified plants. EFSA J 2017; 15:UNSP4862. doi: 10.2903/j.efsa.2017.4862.

2. Radauer C. Wegweiser durch den Allergendschungel: Allergendatenbanken, ihre Merkmale und Anwendungsgebiete. Karger Kompass Pneumol 2017; 5:138-148. doi: 10.1159/000478040.

d) Book contributions: n = 7

1. Kleine-Tebbe J, Ballmer-Weber BK, Breiteneder H, Vieths S. Bet v 1 and its Homologs: Triggers of Tree-Pollen Allergy and Birch Pollen-Associated Cross-Reactions. In: Jörg Kleine-Tebbe, Thilo Jakob (eds.). Molecular Allergy Diagnostics, Springer International Publishing, Switzerland, 2017; pp. 21-42. doi 10.1007/978-3-319-42499-6_2

2. Breiteneder H. Biomolecular and clinical aspects of food allergy. In: Andreas L. Lopata (ed.). Food Allergy, Molecular and Clinical Practice, CRC Press 2017, pp 1-29.

3. Ballmer-Weber BK, Hoffmann-Sommergruber K. Molecular Diagnostics of Allergy to Fruits and Vegetables. In: Jörg Kleine-Tebbe, Thilo Jakob (eds.). Molecular Allergy

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Diagnostics, Springer International Publishing, Switzerland, 2017; pp. 271-289. doi 10.1007/978-3-319-42499-6_14

4. Kleine-Tebbe J, Ollert M, Radauer C, Jakob T. Introduction to Molecular Allergology: Protein Families, Databases, and Potential Benefits. In: Jörg Kleine-Tebbe, Thilo Jakob (eds.). Molecular Allergy Diagnostics, Springer International Publishing, Switzerland, 2017; pp. 3-19. doi 10.1007/978-3-319-42499-6_1

5. Radauer C, Kleine-Tebbe J, Beyer K. Stable Plant Food Allergens II: Storage Proteins. In: Jörg Kleine-Tebbe, Thilo Jakob (eds.). Molecular Allergy Diagnostics, Springer International Publishing, Switzerland, 2017; pp. 77-90. doi 10.1007/978-3-319-42499- 6_5

6. Kuehn A, Radauer C, Lopata AL, Kleine-Tebbe J, Swoboda I. Extract-Based and Molecular Diagnostics in Fish Allergy. In: Jörg Kleine-Tebbe, Thilo Jakob (eds.). Molecular Allergy Diagnostics, Springer International Publishing, Switzerland, 2017; pp. 381-397. doi 10.1007/978-3-319-42499-6_20

7. Radauer C. Nomenclature of Food Allegens. In: Andreas L. Lopata (ed.). Food Allergy, Molecular and Clinical Practice, CRC Press 2017, pp 30-40.

e) Abstracts, printed in periodicals: n = 4

1. Dubiela P, Kabasser S, Geiselhart S, Bublin M, Hafner C, Mazzucchelli G, Hoffmann- Sommergruber K. Purification and characterization of a novel allergenic walnut vicilin- like protein. European Academy of Allergy and Clinical Immunology (EAACI) Meeting, June 17-21, 2017, Helsinki, Finland; Allergy 2017; 72(S103):186

2. Palladino C, Kalic T, Ellinger I, Waltl EE, Mayr V, Niederberger-Leppin V, Palomares O, Breiteneder H. Peanut allergens Ara h 1 and Ara h 2 and peanut lipids impact on the barrier function of human airway epithelial cells. European Academy of Allergy and Clinical Immunology (EAACI) Meeting, June 17-21, 2017, Helsinki, Finland; Allergy 2017; 72(S103):797-798

3. Tscheppe A, Palmberger D, Radauer C, Bublin M, Hafner C, Hemmer W, Mayr V, Palladino C, Gepp B, Lengger N, Grabherr R, Breiteneder H. Contribution of conformational and linear IgE epitopes to Ara h 2-specific IgE-binding. European Academy of Allergy and Clinical Immunology (EAACI) Meeting, June 17-21, 2017, Helsinki, Finland; Allergy 2017; 72(S103):794

4. Tscheppe A, Palmberger D, Radauer C, Bublin M, Hafner C, Hemmer W, Mayr V, Palladino C, Gepp B, Lengger N, Grabherr R, Breiteneder H. Influence of Conformational and Linear IgE Epitopes on Ara h 2-specific IgE-Binding. AAAAI Annual Meeting, March 3-6, 2017, Atlanta, Georgia, United States of America; J Allergy Clin Immunol. 2017;139(2):AB378

f) Abstracts, in congress proceedings or abstract books: n = 22

1. Dubiela P, Kabasser S, Geiselhart S, Bublin M, Hafner C, Mazzucchelli G, Hoffmann-Sommergruber K. Jug r 6 is the walnut allergenic vicilin responsible for IgE cross-reactivities to other tree nuts. Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), November 23-25, 2017, Vienna, Austria

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2. Dubiela P, Aina R, Humeniuk P, Geiselhart S, Bublin M, Polak D, Cantini F, Borowski T, Bohle B, Alessandri S, Hoffmann-Sommergruber K. Impact of free fatty acids binding on the tertiary structure and allergenic activity of the major peach allergen Pru p 3. 13th Annual Young Scientist Association (YSA) Symposium, June 8-9, 2017, Vienna, Austria

3. Dubiela P, Aina R, Humeniuk P, Geiselhart S, Bublin M, Polak D, Cantini F, Borowski T, Bohle B, Alessandri S, Hoffmann-Sommergruber K. Impact of free fatty acids binding on the tertiary structure and allergenic activity of the major peach allergen Pru p 3. 15th European Academy of Allergy and Clinical Immunology (EAACI) Winter School, January 26-29, 2017, Sierra Nevada, Spain

4. Geiselhart S, Nagl C, Dubiela P, Pedersen AC, Bublin M, Radauer C, Bindslev- Jensen C, Hoffmann-Sommergruber K, Mortz CG. Sensitization to seed storage proteins is linked to allergic reactions to buckwheat. Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), November 23-24, 2017, Vienna, Austria

5. Humeniuk P, Paster W, Geiselhart S, Webb T, Steinberger P, Hoffmann- Sommergruber K. A Jurkat based NFκB-eGFP iNKT reporter cell line to evaluate the interaction of food-derived lipids with iNKT cell receptors. 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 19, 2017, Vienna, Austria

6. Humeniuk P, Paster W, Geiselhart S, Webb T, Steinberger P, Hoffmann- Sommergruber K. A Jurkat based NFκB-eGFP iNKT reporter cell line to evaluate the interaction of food-derived lipids with iNKT cell receptors. MCCA & IAI Joint Symposium: Together One Step Further, September 25-27, 2017, Vienna, Austria

7. Humeniuk P, Paster W, Geiselhart S, Webb T, Steinberger P, Hoffmann- Sommergruber K. A Jurkat based NFκB-eGFP iNKT reporter cell line to evaluate the interaction of food-derived lipids with iNKT cell receptors. 10th International CD1-MR1 Workshop, November 3-7, 2017, Napa, California, United States

8. Humeniuk P, Paster W, Geiselhart S, Webb T, Steinberger P, Hoffmann- Sommergruber K. A Jurkat based NFκB-eGFP iNKT reporter cell line to evaluate the interaction of food-derived lipids with iNKT cell receptors. Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), November 23-25, 2017, Vienna, Austria

9. Kalic T, Radauer C, Ruethers T, Taki A, Linhart B, Swoboda I, Morel F, Hilger C, Hoffmann-Sommergruber K, Hafner C, Lopata A, Morisset M, Kuehn A, Breiteneder H. Investigation of clinical and immunological reactivities of the major fish allergens parvalbumins. Annual Meeting of the Austrian Society of Allergology and Immunology (ÖGAI), November 23-25, 2017, Vienna, Austria

10. Kalic T, Radauer C, Ruethers T, Taki A, Linhart B, Swoboda I, Morel F, Hilger C, Hoffmann-Sommergruber K, Hafner C, Lopata A, Morisset M, Kuehn A, Breiteneder H. Investigation of clinical and immunological reactivities of the major fish allergens parvalbumins.

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SFB F46 ´Towards Prevention and Therapy of Allergy´ work in progress meeting, November 5-7, 2017, Ottenstein, Austria

11. Kalic T, Radauer C, Ruethers T, Taki A, Linhart B, Swoboda I, Morel F, Hilger C, Hoffmann-Sommergruber K, Hafner C, Lopata A, Morisset M, Kuehn A, Breiteneder H. Investigation of clinical and immunological reactivities of the major fish allergens parvalbumins. 3rd ImpARAS Conference. October 10-12, 2017, Helsingor, Denmark

12. Kalic T, Ellinger I, Radauer C, Linhart B, Waltl E, Palladino C, Niederberger V, Hafner C, Breiteneder H. Interaction of natural and mutant fish parvalbumins and fish-derived food matrix with bronchial epithelial cells. Joint MCCA-IAI PhD Student Symposium, September 25-26, 2017, Vienna, Austria

13. Kalic T, Radauer C, Ruethers T, Taki A, Linhart B, Swoboda I, Morel F, Hilger C, Hoffmann-Sommergruber K, Hafner C, Lopata A, Morisset M, Kuehn A, Breiteneder H. Investigation of clinical and immunological reactivities of the major fish allergens parvalbumins. Annual research retreat of the Centre for Biodiscovery and Molecular Development of Therapeutics (CBMDT) and the Centre for Biosecurity of Tropical Infections Diseases (CBTID) of the James Cook University, September 8-9, 2017, Cairns, Australia

14. Kalic T, Ellinger I, Radauer C, Linhart B, Waltl E, Palladino C, Niederberger V, Hafner C, Breiteneder H. Interaction of natural and mutant fish parvalbumins and fish-derived food matrix with bronchial epithelial cells. 13th Annual Young Scientist Association (YSA) Meeting, June 8-9, 2017, Vienna, Austria

15. Kalic T, Ellinger I, Radauer C, Linhart B, Waltl E, Palladino C, Niederberger V, Hafner C, Breiteneder H. Interaction of natural and mutant fish parvalbumins and fish-derived food matrix with bronchial epithelial cells. 15th European Academy of Allergy and Clinical Immunology (EAACI) Winter School, January 26-29, 2017, Sierra Nevada, Spain

16. Tscheppe A, Palmberger D, Bublin M, Radauer C, Palladino C, Gepp B, Lengger N, Grabherr R, Breiteneder H. Recombinant production of a hypoallergenic variant of the major peanut allergen Ara h 2 in the baculovirus insect cell system. 15th European Academy of Allergy and Clinical Immunology (EAACI) Winter School, January 26-29, 2017, Sierra Nevada, Spain

17. Tscheppe A, Palmberger D, Radauer C, Bublin M, Hafner C, Palladino C, Gepp B, Lengger N, Mayr V, Grabherr R, Breiteneder H. Influence of conformational and linear IgE-binding epitopes on Ara h 2-specific IgE-binding. 15th European Academy of Allergy and Clinical Immunology (EAACI) Winter School, January 26-29, 2017, Sierra Nevada, Spain

18. Tscheppe A, Palmberger D, Radauer C, Bublin M, Hafner C, Hemmer W, Palladino C, Gepp B, Lengger N, Mayr V, Grabherr R, Breiteneder H. Influence of conformational and linear IgE-binding epitopes on Ara h 2-specific IgE-binding. 13th Annual Young Scientist Association (YSA) Meeting, June 8-9, 2017, Vienna, Austria

19. Tscheppe A, Palmberger D, Radauer C, Bublin M, Hafner C, Hemmer W, Palladino C, Gepp B, Lengger N, Mayr V, Grabherr R, Breiteneder H. Contribution of conformational and linear IgE epitopes to Ara h 2-specific IgE-binding

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MCCA & IAI Joint Symposium: Together One Step Further, September 25-27, 2017, Vienna, Austria

20. Tscheppe A, Palmberger D, Radauer C, Van Rijt L.S, Bublin M, Hafner C, Hemmer W, Mayr V, Palladino C, Logiantara A, Van Ree R, Grabherr R, Breiteneder H. Contribution of conformational and linear IgE epitopes to Ara h 2-specific IgE-binding – in vitro and in vivo studies. Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), November 23-25, 2017, Vienna, Austria

21. Uranowska K, Kalic T, Karapandža K, Ellinger I, Breiteneder H, Schaider H, Hafner C. Expression of chondroitin sulfate proteoglycan 4 (CSPG4) in BRAF-mutant induced drug-tolerant melanoma cells. Annual Meeting of the Austrian Society for Allergology and Immunology (ÖGAI), November 23-25, 2017, Vienna, Austria

22. Uranowska K, Kalic T, Karapandža K, Breiteneder H, Schaider H, Hafner C. Generation of induced drug-tolerant melanoma cells (IDTCs). 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 19, 2017, Vienna, Austria

g) Teaching Scripts and Books, n = 18

Breiteneder Heimo:

Teaching script for MCCA Lecture, Thesis Seminar and Basic Course Series on Food Allergy & Anaphylaxis, 861.006, WS2016/17.

1. Expression systems: an overview

Teaching scripts for Immunobiology and Vascular Diseases (cooperation between MedUni and BOKU for “Master Biotechnology”) 881.004/791.363, SS2017.

1. Protein allergens: sources, structures and significance 2. Recognition of microbes and damaged self (Innate Immunity 1) 3. Cell-associated pattern recognition receptors (Innate Immunity 2) 4. Soluble recognition and effector molecules (Innate Immunity 3) 5. Cells of the innate immune system (Innate Immunity 4)

Hoffmann-Sommergruber Karin:

Teaching Scripts for Infectious Diseases and Vaccine development (cooperation for “Master Medical Biotechnology MedUni and BOKU) 881.001:

1. Immunology 2. Molecular Biology and diagnostic methods 3. Bacterial Infections 4. Parasitic Infections 5. Vaccine design and adjuvants

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Teachings Scripts for MCCA Lecture Series 861.003, MCCA Lecture, Thesis Seminar and Basic Course Series on Food Allergy & Anaphylaxis:

1. Food Allergy and Intolerances

Teachings Scripts for MCCA Lecture, 861.004, Thesis Seminar and Basic Course Series on Recombinant Allergens & Structural Biology:

1. Recombinant Food Allergens: Generation, characterization and application

Radauer Christian:

Master curriculum Medical Biotechnology, jointly organized by the Medical University of Vienna and the University of Natural Resources and Life Sciences, Vienna: Lecture: Biological Therapeutics

1. Immunoglobulins: structure and function 2. Development and production of therapeutic antibodies 3. Therapeutic full-length polyclonal and monoclonal antibodies 4. Recombinant antibody derivatives 5. Antibody conjugates and fusion proteins

h) Articles in Medical Journals: n = 0

i) Public Activity: n = 0

1.4.2. Research Awards: n = 14

Dubiela Pawel received a poster award for: Dubiela P, Aina R, Humeniuk P, Geiselhart S, Bublin M, Polak D, Cantini F, Borowski T, Bohle B, Alessandri S, Hoffmann-Sommergruber K: Impact of free fatty acids binding on the tertiary structure and allergenic activity of the major peach allergen Pru p 3. Poster presentation at the YSA Congress, June 8-9, 2017, Vienna, Austria

Dubiela Pawel received a travel grant for: Dubiela P, Kabasser S, Geiselhart S, Bublin M, Mazzucchelli G, Hoffmann-Sommergruber K: Purification and characterization of a novel allergenic walnut vicilin-like protein. Abstract presentation at the Annual European Academy of Allergy and Immunology Congress (EAACI), June 17-21, 2017, Helsinki, Finland. Honor issuer: The Austrian Society for Allergology and Immunology (ÖGAI)

Dubiela Pawel received a travel grant for a Scientific Internship to perform project on Stability of walnut allergens

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University of Belgrade, Sep 10-23, 2017 Belgrade, Serbia Honor issuer: The Scientific & Technological Cooperation (S&T Cooperation)

Dubiela Pawel received a travel grant based on his CV and cover letter for: European Advanced Course in Basic and Clinical Immunology Oct 16-18, 2017, Prague, Czech Republic Honor issuer: The Federation of Clinical Immunology Societies (FOCIS)

Humeniuk Piotr received a travel grant for: Humeniuk P, Paster W, Geiselhart S, Webb T, Steinberger P, Hoffmann-Sommergruber K: A Jurkat based NFkB-EGFP iNKT reporter cell line to evaluate the interaction of food-derived lipids with iNKT cells receptor Abstract presentation at the 10th International CD1-MR1 Workshop, November 3-7, 2017, Napa, United States Honor issuer: The Austrian Society for Allergology and Immunology (ÖGAI)

Kalic Tanja received an award for: Kalic T, Ruethers T, Radauer C, Taki AC, Linhart B, Swoboda I, Morel F, Hilger C, Hoffmann-Sommergruber K, Hafner C, Lopata AL, Morisset M, Kuehn A, Breiteneder H: Investigation of clinical and immunological reactivities of the major fish allergens parvalbumins. Oral flash presentation at the 3rd ImpARAS Conference, October 10-12, 2017, Helsingor, Denmark

Kalic Tanja received a poster award for: Kalic T, Ruethers T, Radauer C, Taki AC, Linhart B, Swoboda I, Morel F, Hilger C, Hoffmann-Sommergruber K, Hafner C, Lopata AL, Morisset M, Kuehn A, Breiteneder H: Investigation of clinical and immunological reactivities of the major fish allergens parvalbumins. Poster presentation at the 5th SFB F46 work in progress meeting, November 5–7, 2017, Ottenstein, Austria

Mayr Vanessa received a poster award for: Mayr V, Bublin M, Nagl C, Breiteneder H: Establishment of a new expression platform for plant allergens Poster presentation at the ÖGAI, November 23-25, 2017, Vienna, Austria Honor issuer: The Austrian Society for Allergology and Immunology (ÖGAI)

Palladino Chiara received a travel grant for: Palladino C, Kalic T, Ellinger I, Waltl E, Niederberger V, Palomares O, Breiteneder H: Peanut major allergens and peanut lipids impact on barrier function of human airways epithelial cells. Abstract presentation at the 12th ENII EFUS EJI Summer School on Advanced Immunology, May 6-13, 2017, Porto Cervo, Sardinia, Italy Honor issuer: EFIS-EJI (European Federation of Immunological Society – European Journal of Immunlogy)

Palladino Chiara received a travel grant for: Palladino C, Kalic T, Ellinger I, Waltl E, Mayr V, Niederberger V, Palomares O, Breiteneder H: Peanut allergens Ara h 1 and Ara h 2 and peanut lipids impact on barrier function of human airways epithelial cells. Abstract presentation at the Annual European Academy of Allergy and Immunology Congress (EAACI), June 17-21, 2017, Helsinki, Finland. Honor issuer: The Austrian Society for Allergology and Immunology (ÖGAI)

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Palladino Chiara received a poster award for: Palladino C, Kalic T, Ellinger I, Radauer C, Hafner C, Hemmer W, Mayr V, Waltl E, Niederberger V, Palomares O, Breiteneder H: Peanut allergens Ara h 1 and Ara h 2 and peanut lipids impact on barrier function of human airways epithelial cells. Abstract presentation at the Annual European Academy of Allergy and Immunology Congress (EAACI), June 17-21, 2017, Helsinki, Finland. Honor issuer: European Academy of Allergy and Clinical Immunology EAACI

Tscheppe Angelika received a travel grant for: Tscheppe A, Palmberger D, Radauer C, Bublin M, Hafner C, Hemmer W, Mayr V, Palladino C, Gepp B, Lengger N, Grabherr R, Breiteneder H: Influence of conformational and linear IgE epitopes on Ara h 2-specific IgE binding. Abstract presentation at the American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting, March 3-6, 2017, Atlanta, Georgia, USA. Honor issuer: The Austrian Society for Allergology and Immunology (ÖGAI

Tscheppe Angelika received a Short Term Scientific Mission (STSM) grant for the research stay at the Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, The Netherlands, June 23-September 20, 2017 Honor issuer: ImPARAS Cost action 1402

1.4.3. Invited lectures: n = 12

Breiteneder Heimo:

1. Swiss Society for Allergology and Immunology 19th Course: Allergy and Immunology Update “What makes proteins allergenic – are there clinical implications?” January 20-22, 2017, Grindelwald, Switzerland

2. Diamantina Institute of The University of Queensland, Dermatology Research Centre “Evolutionary aspects of the allergenicity of proteins” April 26-28, 2017, Brisbane, Australia

3. 9. Kärntner Allergiegespräch Veranstalter: Die Ärztekammer für Kärnten, Arbeitsgemeinschaft der Kärntner Lungenfachärzte, allergieausübende Fachgruppe Dermatologie, HNO, Kinder- und Jugendheilkunde “Schlangen, Skorpione, Allergie” May 11-13, 2017

4. 8. Salzburger Allergietagung Veranstalter: Verein zur Förderung der Universitätsklinik für Dermatologie, Österreichische Gesellschaft für Dermatologie, Arbeitsgruppe Allergologie “Biologische Ursachen der Typ I Allergie” September 22-23, 2017, Salzburg, Austria

5. 7th International Symposium on Molecular Allergology Allergen nomenclature meeting “Allergen structure and function – What is important” November 8-10, 2017, Luxembourg

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Hoffmann-Sommergruber Karin:

1. Fortbildung der Österreichischen Ärztekammer Ernährungsmedizin „Gentechnisch veränderte Lebensmittel“ March 25, 2017, Vienna, Austria

2. EAACI Annual Meeting „New approaches to the diagnosis and management of food allergy: Roadmap to oral abstract session“ June 17-21, 2017, Helsinki, Finland

3. EAACI Annual Meeting „New approaches to management of drug allergy: Roadmap to oral abstract session“ June 17-21, 2017, Helsinki, Finland

4. EAACI Annual Meeting „Reducing exposure: Genetically modified allergen sources“ June 17-21, 2017, Helsinki, Finland

5. Fortbildungskurs: Lebensmitteltoxikologie “Nahrungsmittelallergien und Unverträglichkeiten” September 9, 2017, Kaiserslautern, Germany

6. European Proteomics Association (EuPA) & Human Proteome Organizsation (HUPO) Clinical Proteomics Postgenome Medicine “Proteomics and its application to improve diagnosis and management of the food allergic patient.” October 30 – November 1, 2017, Moscow, Russia

Radauer Christian:

1. 9. Wiener Komponentenschule – Allergien besser verstehen Veranstalter: Thermo-Fisher Österreich “Allergene: Definition, Nomenklatur und Datenbanken” September 1-2, 2017, Vienna, Austria

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1.4.4. Congress organization

Division member National congress Intern. Congress, Function Function Name: Name, date Name, date Hoffmann- ÖGAI Annual Member Sommergruber Meeting, Nov. 23 – of LOC 25, 2017, Vienna Karin

1.4.5. Hosting speakers

division member Speaker´s name Affiliation Date

1.4.6. Mobility

Name Program University, Time frame Division In Out Country Dubiela Pawel Scientific Internship University of September 4 x as visiting researcher Belgrade, Faculty 10-23, 2017 of Chemistry, Velickovic Lab. Center of Excellence for Molecular Food Sciences Belgrade, Serbia Humeniuk Piotr Scientific Internship University of January 7 – 4 x as visiting researcher Maryland School April 10, to learn techniques of Medicine, 2017 used in natural killer T Department of lymphocytes studies Microbiology & Immunology, Assoc. Prof. Tonya J. Webb Baltimore, Maryland, USA Kalic Tanja Scientific Internship James Cook June 21 – 4 x as visiting researcher: University, Centre September Characterization of for Biodiscovery 19, 2017 fish allergens and Molecular Development of Therapeutics, Department of Molecular and Cell Biology Townsville, Australia Tscheppe Scientific Internship University of June 23 – 4 x Angelika as visiting researcher: Amsterdam, October 10, Investigation of the Department of 2017 hypoallergenic and Experimental immunogenic

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potential of Ara h 2 Immunology mutants in a peanut Amsterdam, allergic mouse model Netherlands Kysel Matus Scientific Internship University of November 4 x Bratislava 13 – 22, WTZ Mulitlateral 2017 Danube Project Bratislava, Slovakia Mastrorilli Carla EAACI Research University of June 4 – 4 x Fellowship Parma, December 3, Department of 2017 Medicine and Surgery, Pediatric Allergy and Immunology Unit, Pediatric Clinics Parma, Italy Prodic Ivana Scientific Internship University of November 6 4 x Belgrade – 17, 2017 COST Action ImpARAS Belgrade, Serbia

1.4.7. Activities in Advisory Boards

Name Society/Institute/Journal Function Breiteneder Heimo WHO/IUIS Allergen Member Nomenclature Sub-Committee Breiteneder Heimo AllFam Allergen Family Member of the scientific advisory database board Breiteneder Heimo SDAP database Member of the scientific advisory board Breiteneder Heimo IGAV Member Bublin Merima COST Action: “Imparas” MC Member Bublin Merima AllFam Allergen Family Member of the scientific advisory Database board Hoffmann-Sommergruber Karin IGAV Member Hoffmann-Sommergruber Karin EAACI (European Academy of Board Member (VP of Allergy and Clinical Communication and Immunology) Membership) Hoffmann-Sommergruber Karin COST Action: “Imparas” MC Member Hoffmann-Sommergruber Karin Pirquet Club Scientific secretary Radauer Christian WHO/IUIS Allergen Member Nomenclature Sub-Committee Radauer Christian AllFam Allergen Family Project Leader, Database Database Administrator

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1.4.8. Editorial Activities

Name Journal Function Breiteneder Heimo International Archives of Allergy Member of the Editorial board and Immunology Hoffmann-Sommergruber Karin International Archives of Allergy Member of the Editorial Board and Immunology

1.4.9. Review Activities

Name Grants/Thesis/Habilitation Hoffmann-Sommergruber Karin Reviewer for PhD Thesis: Lorenz Aglas: “Intrinsic properties of the Bet v 1 fold: impact on immunogenicity and allergenicity“ University of Salzburg, Austria Hoffmann-Sommergruber Karin Review of a research grant application for the German National Research Agency Hoffmann-Sommergruber Karin Review of a research fellowship from the Austrian Academy (ÖAD, Ernst Mach Stipendium) Radauer Christian Review of a research grant application for the French National Research Agency

1.4.10. Filed and granted patents

Name Patent Van den Driesche S, Vellekoop Method for carrying out an allergy test, method for determining M, Falldorf C, Hafner C, degranulation in cells, device for carrying out an allergy test and Breiteneder H. microfluidic chip. Patent filed: September 14, 2017.

1.4.11. Grants

Funding agency Title of project Principal investigator Fonds zur Förderung Doktoratskolleg Molecular, cellular and clinical Heimo Breiteneder der wissenschaftl. Allergology, MCCA Forschung, DK W 1248-B13 n(f+b) The role of chondroitin sulfate proteoglycan 4 Heimo Breiteneder (NÖ Forschungs- und (CSPG4) in the induction of multidrug BildungsgesmbH) tolerance in melanoma cells Life Science Call LSC 15-007 FWF (Austrian Science Structure function relationship of food Karin Hoffmann- Fund), SFB F4601-B19 allergens. Sommergruber Fonds zur Förderung Doktoratskolleg Molecular, cellular and clinical Karin Hoffmann- der wissenschaftl. Allergology, MCCA Sommergruber Forschung, DK W 1248-B13 MacroArrayDx Herstellung, Reinigung und Aufbereitung von Merima Bublin Reinigung von Nahrungsmittel Allergenen sowie Allergenen wissenschaftliche Dokumentation

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1.4.12. Career Developments a) Habilitations: n = 0

b) Habilitations in progress: n = 0

c) Professorships: n = 0

d) Qualification Agreement: n = 1

Bublin Merima 01.12.2015 – 30.11.2018

1.4.13. Teaching a) Bachelor students: n = 1

Schneider Jaana Bachelor Thesis: Expression and Characterization of Bacillus subtilis YoaJ (EXLX1), a putative non-IgE binding structural homologue of Phl p 1 (group 1 grass pollen allergen) in E. coli. January to May 2017

b) Diploma, MDiploma and Master students: n = 3

Grasserbauer Günther Master Thesis: Production of recombinant walnut allergens in P. pastoris. (Feb. 2017 – in progress)

Iskakova Zarina MD Thesis: Bestimmung der Allergensensibilisierungsmuster bei Erdnussallergikern mit Baumnussallergie. (May 2017 – in progress)

Kabasser Stefan Master Thesis: Expression of allergenic seed storage proteins from walnut in P. pastoris. (December 2015 – in progress)

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Performance Report 2017 – Division 4 Medical Biotechnology c) PhD, MDSci, MD students: n = 7

Dubiela Pawel: PhD Thesis: Production and characterization of recombinant food allergens: Their epitope analysis and implications for cross-reactivity. (October 2013 – in progress)

Humeniuk Piotr: PhD Thesis: Food Allergens and interaction with the human immune system. (October 2014 – in progress)

Kalic Tanja: PhD Thesis: Characterization of reactions of epithelial cells responsible for high allergenicity of Gad m 1, the major allergen from Atlantic cod. (October 2014 – in progress)

Palladino Chiara: PhD Thesis: Biological and allergenic activities of peanut allergens. (October 2013 – in progress)

Tscheppe Angelika: PhD Thesis: Expression of Ara h 2 wildtype and hypoallergenic mutants in insect and plant cells. (October 2014 – in progress)

Uranowska Karolina: PhD Thesis: The role of chondroitin sulfate proteoglycan 4 (CSP64) in the induction of multidrug tolerance in melanoma cells. (October 2017 – in progress)

Üzülmez Öykü PhD Thesis: Transient expression of plant allergens in Nicotiana benthamiana. (September 2017 – in progress)

1.4.14. Exams a) Oral exams n = 0

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Performance Report 2017 – Division 4 Medical Biotechnology b) Diploma and Thesis-Exams: n = 5

Breiteneder Heimo:

Zulehner Nora Defensio Dissertation: February 27, 2017 „Characterization of different phenotypes of allergen-specific Th2 cells”

Fafgelj Veronika Defensio Diplomarbeit: November 15, 2017 „Confirmation of whole mRNA array data of Ara h 2 specific T cells”

Laurer Elisabeth Defensio Diplomarbeit: November 15, 2017 “The basophil activation test as a diagnostic tool to delineate food allergic from food tolerant children"

Bublin Merima:

Luan Kui Beurteilung der Master Thesis: August 24, 2017 „Effekt von Qigong auf chronische Schmerzen in der Komplementärmedizin –Eine Meta-Analyse“ Universitätslehrgang Traditionelle Chinesische Medizin (TCM)“; Medizinische Universität Wien

Heuberger Andrea Wilhemine Defensio of MD: November 21, 2017 “Long-term clinical follow-up of patients with ST-segment elevation myocardial infarction receiving either Genous or Taxus stent”

c) Exam supervising: n = 2

Breiteneder Heimo: SIP2, Z-SIP2, Saalleiter, 28.06.2017

Radauer Christian: SIP1, Saalleiter, 27.06.2017

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1.4.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2017 Breiteneder Heimo 2.00 2.00 514057 Dissertanten- und Diplomandenseminar Breiteneder Heimo 1.00 1.00 514073 Anleitung zum wissenschaftlichen Arbeiten Breiteneder Heimo 2.00 0.13 861007 MCCA Journal Club Breiteneder Heimo 2.00 0.67 881004 Immunobiology and Vascular Diseases Bublin Merima 1.00 1.00 800000 Senior-Mentoring Humanmedizin Bublin Merima 4.00 0.50 808004 SSM 3-Projektstudie (Wahlpflichtteil) Hoffmann-Sommergruber Karin 2.00 0.13 861007 MCCA Journal Club Radauer Christian 1.00 1.00 648801 Journal Club and Progress Report - Division of Medical Biotechnology Sum 6.43 WS 2017/18 Breiteneder Heimo 2.00 2.00 514057 Dissertanten- und Diplomandenseminar Breiteneder Heimo 1.00 1.00 514073 Anleitung zum wissenschaftlichen Arbeiten Breiteneder Heimo 2.00 0.13 861007 MCCA Journal Club Breiteneder Heimo 2.00 0.44 861110 MCCA Lecture, Thesis Seminar and Basic Course Series on Allergens Bublin Merima 1.00 1.00 800000 Senior-Mentoring Humanmedizin Bublin Merima 2.20 0.53 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Geiselhart Sabine 2.20 0.27 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Hoffmann-Sommergruber Karin 2.20 0.53 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Hoffmann-Sommergruber Karin 2.00 0.22 861110 MCCA Lecture, Thesis Seminar and Basic Course Series on Allergens Hoffmann-Sommergruber Karin 2.00 0.13 861007 MCCA Journal Club Hoffmann-Sommergruber Karin 2.00 1.00 881001 Infectious Diseases and Vaccines Radauer Christian 1.00 1.00 648014 Journal Club and Progress Report - Division of Medical Biotechnology Radauer Christian 2.20 0.53 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder Radauer Christian 2.00 1.00 881000 Biological Therapeutics Sum 9.78 Total sum SS+WS 16.21

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Performance Report 2017 – Division 6 Experimental Allergology

1.5. Division for Experimental Allergology Head: Barbara Bohle, Professor

1. Publications8 IF Number Top/Std/Subst Bohle Barbara 23.950 11 9/3/0 Beatrice Jahn-Schmid 6.731 4 2/2/0 Division-Sum 28.648 Top point score 2 - among top 20 % of journal in field Standard point score 1 - between 21-60 %, Substandard point score 0,2

2. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st. Bohle Barbara 5 Beatrice Jahn-Schmid 2 Sum 7

3. Teaching SS* WS* total W+S oral Exams Bohle Barbara 8.98 9.25 18.23 5 Beatrice Jahn-Schmid 2.53 5.4 7.93 2 Sum 11.51 14.65 26.16 7

8 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the given sum of the division represents the net value of IFs without overlaps due to joint publications. 127

Performance Report 2017 – Division 6 Experimental Allergology

1.5.1. Publications a) Peer-reviewed original articles: n = 12

Nr. Article IF Class pro-rata IF 1. Leone DA, Peschel A, Brown M, Schachner H, Ball MJ, 4.856 Top 0.971 Gyuraszova M, Salzer-Muhar U, Fukuda M, Vizzardelli C, Bohle B, Rees AJ, Kain R. Surface LAMP-2 Is an Endocytic Receptor That Diverts Antigen Internalized by Human Dendritic Cells into Highly Immunogenic Exosomes. J Immunol. 2017 Jul 15;199(2):531-546. doi: 10.4049/jimmunol.1601263.

2. M. Wolf, T. E. Twaroch, S. Huber, M. Reithofer, M. Steiner, 7.361 Top 1.472 L. Aglas, M. Hauser, I. Aloisi, C. Asam, H. Hofer, M. A. Parigiani, C. Ebner, B. Bohle, P. Briza, A. Neubauer, F. Stolz, B. Jahn-Schmid, M. Wallner, F. Ferreira. Amb a 1 isoforms: Unequal siblings with distinct immunological features. Allergy, Dec. 2017,1874-1882 DOI 10.1111/all.13196 3. Pablos I., S. Eichhorn, Y. Machado, P. Briza, A. 7.361 Top 1.472 Neunkirchner, B. Jahn-Schmid, S. Wildner, W.T. Soh, C. Ebner, J.W. Park, W.F. Pickl, N. Arora, S. Vieths, F. Ferreira, G. Gadermaier. Distinct epitope structures of defensin-like proteins linked to proline rich regions give rise to differences in their allergenic activity. Allergy, 72:1874-1882, 2017 doi: 10.1111/all.13298 4. Groh N, von Loetzen CS, Subbarayal B, Möbs C, Vogel L, 5.264 Top 1.052 Hoffmann A, Fötisch K, Koutsouridou A, Randow S, Völker E, Seutter von Loetzen A, Rösch P, Vieths S, Pfützner W, Bohle B, Schiller D. IgE and allergen-specific immunotherapy-induced IgG4 recognize similar epitopes of Bet v 1, the major allergen of birch pollen. Clin Exp Allergy. 2017 May;47(5):693-703. 5. P Dubiela, R Aina, D Polak, S Geiselhart, P Humeniuk, B 13.081 Top 2.616 Bohle, S Alessandri, R Del Conte, F Cantini, T Borowski, M

Bublin, K Hoffmann-Sommergruber. Enhanced Pru p 3 IgE-binding activity by selective free fatty acid-interaction. Journal of Allergy and Clinical Immunology, 2017 Dec;140(6):1728-1731.e10. doi: 10.1016/j.jaci.2017.06.016. Epub 2017 Jul 14 6. Kollmann D., Nagl B., Ebner C., Emminger W., Wöhrl S., 7.361 Top 7.361 Kitzmüller C., Vrtala S., Mangold A., Ankersmit HJ., Bohle B. The quantity and quality of α-gal-specific antibodies differ in individuals with and without delayed red meat allergy. Allergy. 2017 Feb;72(2):266-273. doi: 10.1111/all.12948. Epub 2016 Jul 15. 7. Zulehner N., Nagl B., Briza P., Roulias A., Ballmer-Weber 7.361 Top 7.361 B., Zlabinger GJ, Ferreira F., Bohle B. Characterization of the T-cell response to Dau c 1, the Bet v 1-homolog in carrot. Allergy. 2017 Feb;72(2):244-251. doi: 10.1111/all.12938. Epub 2016 Jun 10.

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8. Soh WT, Briza P, Dall E, Asam C, Schubert M, Huber S, 3.226 Std 0.645 Aglas L, Bohle B, Ferreira F, Brandstetter H. Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S. Int J Mol Sci. 2017 Oct 16;18(10). pii: E2156. doi: 10.3390/ijms18102156. 9. Shamji MH, Kappen JH, Akdis M, Jensen-Jarolim E, Knol 7.361 Top 1.472 EF, Kleine-Tebbe J, Bohle B, Chaker AM, Till SJ, Valenta R,

Poulsen LK, Calderon MA, Demoly P, Pfaar O, Jacobsen L, Durham SR, Schmidt-Weber CB. Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper. Allergy. 2017 Aug;72(8):1156-1173. doi: 10.1111/all.13138. Epub 2017 Apr 6. 10. Hirschl S, Ralser C, Asam C, Gangitano A, Huber S, Ebner 2.720 Std 0.544 C, Bohle B, Wolf M, Briza P, Ferreira F, Griesbeck C, Wallner M. Expression and Characterization of Functional Recombinant Bet v 1.0101 in the Chloroplast of Chlamydomonas reinhardtii. Int Arch Allergy Immunol. 2017;173(1):44-50. doi: 10.1159/000471852. Epub 2017 May 12. 11. Sancho AI, Wallner M, Hauser M, Nagl B, Himly M, Asam C, 2.806 Std 0.561 Ebner C, Jahn-Schmid B, Bohle B, Ferreira F. T Cell Epitope-Containing Domains of Ragweed Amb a 1 and Mugwort Art v 6 Modulate Immunologic Responses in Humans and Mice. PLoS One. 2017 Jan 12;12(1):e0169784. doi: 10.1371/journal.pone.0169784. eCollection 2017. 12. Hofer H, Asam C, Hauser M, Nagl B, Laimer J, Himly M, 13.081 Top 2.616 Briza P, Ebner C, Lang R, Hawranek T, Bohle B, Lackner P,

Ferreira F, Wallner M. Tackling Bet v 1 and associated food allergies with a single hybrid protein. J Allergy Clin Immunol. 2017 Aug;140(2):525-533.e10. doi: 10.1016/j.jaci.2016.09.055. Epub 2016 Dec 7. sum 108.001 41.119

b) Invited Articles & Reviews with IF: n = 1

Nr. Article IF Class pro-rata IF 1 M Reithofer and B Jahn-Schmid. Allergens with Protease 3.226 Std 3.226 Activity from House Dust Mites. Int. J. Mol. Sci. 2017, 18(7), 1368; Doi:10.3390/ijms18071368 sum 3.226 3.226

c) Invited Articles & Reviews without IF: n = 0

d) Book contributions: n = 0

129

Performance Report 2017 – Division 6 Experimental Allergology e) Abstracts, printed in periodicals: n = 0

f) Abstracts, in congress proceedings or abstract books: n = 22

 Vizzardelli, C., Zimmann, F., Nagl B., Gindl, M., Roos, S., Kenner, L., Bohle, B. NSG- mice humanized with allergen-specific CD4+ T cells develop allergic airway responses. Poster presentation at the Austrian Society for Allergology and Immunology (ÖGAI) annual meeting, Vienna, Austria, November, 2017

 Polak, D., Hafner, Ch., Vizzardelli, C., Briza, P., Kitzmüller, C., Sánchez-Acosta, G., Samadi, N., Elbe-Bürger, A., Steinberger, P., Gschwandtner, M., Pfützner, W., Zlabinger, G.J., Jahn-Schmid, B., Bohle, B. Neutrophils promote allergic inflammation by presenting allergen to specific CD4+ T cells. Poster presentation at the 8th Retreat of the Centre for Pathophysiology, Infectiology and Immunology, Vienna, Austria, September, 2017

 Polak, D., Hafner, Ch., Vizzardelli, C., Briza, P., Kitzmüller, C., Sánchez-Acosta, G., Samadi, N., Elbe-Bürger, A., Steinberger, P., Gschwandtner, M., Pfützner, W., Zlabinger, G.J., Jahn-Schmid, B., Bohle, B. Neutrophils promote allergic inflammation by presenting allergen to specific CD4+ T cells. Poster presentation at the IAI/MCCA PhD Joint PhD-Student Symposium - "Together One Step Further", Vienna, Austria, September,2017

 Polak, D., Hafner, Ch., Vizzardelli, C., Briza, P., Kitzmüller, C., Sánchez-Acosta, G., Samadi, N., Elbe-Bürger, A., Steinberger, P., Gschwandtner, M., Pfützner, W., Zlabinger, G.J., Jahn-Schmid, B., Bohle, B. Neutrophils acquire antigen-presenting capacity in allergic late-phase responses. Poster presentation at the SFB/MCCA retreat,Ottenstein,Austria,November,2017

 Polak, D., Hafner, Ch., Vizzardelli, C., Briza, P., Kitzmüller, C., Sánchez-Acosta, G., Samadi, N., Elbe-Bürger, A., Steinberger, P., Gschwandtner, M., Pfützner, W., Zlabinger, G.J., Jahn-Schmid, B., Bohle, B.Neutrophils promote allergic inflammation by presenting allergen to specific CD4+ T cells. Poster presentation at the Austrian Society for Allergology and Immunology (ÖGAI) annual meeting, Vienna, Austria, November, 2017

 M. Reithofer, D. Polak, C. Kitzmüller, B. Bohle, B. Jahn-Schmid. Characterization of neutrophil extracellular traps to alum-adjuvanted allergy vaccines. 47th Annual Meeting of the German Society for Immunology 12 - 15 September, 2017 Erlangen, Germany

 M. Reithofer, S.L. Böll, C. Kitzmüller, F. Horak, M. Sotoudeh, B. Bohle, B. Jahn- Schmid. Alum-Adjuvanted allergoids induce IgE-blocking IgG antibodies in allergen- specific immunotherapy. 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 19, 2017

 M. Reithofer, D. Polak, C. Kitzmüller, B. Bohle, B. Jahn-Schmid. Neutrophil extracellular traps may play a role in alum-adjuvanted allergen-specific immunotherapy. Joint Symposium of 2 PhD Programs, September 25-26, 2017 Vienna

 M. Reithofer, S.L. Böll, C. Kitzmüller, F. Horak, M. Sotoudeh, B. Bohle, B. Jahn- Schmid. Alum-Adjuvanted allergoids induce IgE-blocking IgG antibodies in allergen- specific immunotherapy. ÖGAI Annual Meeting 2017 23.-25.11.2017 in Vienna 130

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 Polak, D., Nagl, B., Hafner, Ch.,Briza, P., Kitzmüller, C., Elbe-Bürger, A., Bohle, B. Human neutrophils serve as antigen-presenting cells for allergen-specific effecttor T- cells Poster presentation at the 15th Immunology Winter School from the European Academy of Allergy and Clinical Immunology, Sierra Nevada, Spain, January 2017

 Polak, D., Nagl, B., Hafner, Ch.,Briza, P., Kitzmüller, C., Elbe-Bürger, A., Bohle, B. Human neutrophils process and present antigens to CD4+ T cells. ePoster presentation at the European Academy of Allergy and Clinical Immunology Annual Congress, Helsinki, Finland, June, 2017

 Polak, D., Nagl, B., Hafner, Ch.,Briza, P., Kitzmüller, C., Elbe-Bürger, A., Bohle, B. Human neutrophils process and present antigens to CD4+ T cells. oral presentation at the 14th YSA PhD Symposium, Vienna, Austria, June, 2017

 Polak, D., Hafner, Ch., Vizzardelli, C., Briza, P., Kitzmüller, C., Sánchez-Acosta, G., Samadi, N., Elbe-Bürger, A., Steinberger, P., Gschwandtner, M., Pfützner, W., Zlabinger, G.J., Jahn-Schmid, B., Bohle, B. Neutrophils promote allergic inflammation by presenting allergen to specific CD4+ T cells. Poster presentation at the IAI/MCCA PhD Joint PhD-Student Symposium - "Together One Step Further", Vienna, Austria, September,2017

 Polak, D., Hafner, Ch., Vizzardelli, C., Briza, P., Kitzmüller, C., Sánchez-Acosta, G., Samadi, N., Elbe-Bürger, A., Steinberger, P., Gschwandtner, M., Pfützner, W., Zlabinger, G.J., Jahn-Schmid, B., Bohle, B. Neutrophils acquire antigen-presenting capacity in allergic late-phase responses. Poster presentation at the SFB/MCCA retreat, Ottenstein, Austria, November, 2017

 Polak, D., Hafner, Ch., Vizzardelli, C., Briza, P., Kitzmüller, C., Sánchez-Acosta, G., Samadi, N., Elbe-Bürger, A., Steinberger, P., Gschwandtner, M., Pfützner, W., Zlabinger, G.J., Jahn-Schmid, B., Bohle, B.Neutrophils promote allergic inflammation by presenting allergen to specific CD4+ T cells. Poster presentation at the Austrian Society for Allergology and Immunology (ÖGAI) annual meeting, Vienna, Austria, November, 2017

 Sánchez Acosta, G., Najafi, N., Flicker, S., Focke-Tejkl, M., Keller, W., Valenta, R. and Bohle, B. The role of allergen-specific IgG antibodies in allergen-specific T cell responses. Poster presentation delivered at the 15th Immunology Winter School from the European Academy of Allergy and Clinical Immunology, Sierra Nevada, Spain, January 2017

 Sánchez Acosta, G., Nagl, B., Kinaciyan, T. and Bohle, B. Antibody responses to sublingual treatment with recombinant Bet v 1 and Mal d 1. Poster presentation delivered at the European Academy of Allergy and Clinical Immunology Annual Congress,Helsinki,Finland,June,2017

 Sánchez Acosta, G., Kinaciyan, T., Möbs, C., Pfützner, W. and Bohle, B. Sublingual immunotherapy with rMal d 1 induces blocking antibodies. Poster presentation

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delivered at the 8th Retreat of the Centre for Pathophysiology, Infectiology and Immunology, Vienna, Austria, September, 2017

 Sánchez Acosta, G., Nagl, B., Kinaciyan, T., Möbs, C., Pfützner, W. and Bohle, B. Allergen-specific antibody responses to sublingual treatment with recombinant Mal d 1 and Bet v 1. Poster presentation delivered at the IAI/MCCA PhD Joint PhD-Student Symposium - "Together One Step Further", Vienna, Austria, September, 2017

 Sánchez Acosta, G., Kinaciyan, T., Möbs, C., Pfützner, W. and Bohle, B. Induction of food-specific blocking antibodies for pollen-related food allergies. Oral presentation delivered at the SFB/MCCA retreat, Ottenstein, Austria, November, 2017

 Sánchez Acosta, G., Kinaciyan, T., Möbs, C., Pfützner, W. and Bohle, B. Allergen- specific antibody responses to SLIT with recombinant Mal d 1 and Bet v 1. Poster presentation delivered at the Austrian Society for Allergology and Immunology (ÖGAI) annual meeting, Vienna, Austria, November, 2017

g) Teaching Scripts and Books: n = 0

h) Articles in Medical Journals: n = 0

i) Public activity n = 20

Barbara Bohle

 20. November 2017, Behandlungsoption gegen Apfelallergie, Standard, https://derstandard.at/2000068142649/Behandlungsoption-gegen-Apfel-Allergie

 21. November 2017, Apfel-Allergen kann Apfelallergie heilen, Heilpraxis, http://www.heilpraxisnet.de/naturheilpraxis/apfel-allergen-kann-apfelallergie- heilen-20171120393204

 21.11.2017, Apfel-Allergen als wirksame Behandlungsoption der Apfelallergie, Bionity.com, http://www.bionity.com/de/news/165787/apfel-allergen-als- wirksame-behandlungsoption-der-apfelallergie.html?WT.mc_id=ca0067

 21-11-2017, Apfel-Allergen als wirksame Behandlungsoption der Apfelallergie, http://www.yumda.de/news/152470/apfel-allergen-als-wirksame- behandlungsoption-der-apfelallergie.html?WT.mc_id=yd0001

 20-11-2017, Trial shows apple allergen as effective treatment option for birch pollen-related apple allergy, https://www.news- medical.net/news/20171120/Trial-shows-apple-allergen-as-effective-treatment- option-for-birch-pollen-related-apple-allergy.aspx

 21-11-2017, Apfel Allergen gegen Allergie, Wiener Zeitung

 21-11-2017, Neue Therapie gegen Apfelallergie, Kurier

 24-07-2017, IgE & IgG Ein Buchstabe macht den großen Unterschied-50 Jahre IgE, Prometeus Verlag  29-04-2017, Allergenen auf der Spur, Gesund und Aktuell 132

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 21-11-2017, Hoffnung f Apfelallergiker, Krone

 13-12-2017, Der westliche Lebensstil fördert die Allergieentstehung, Kurier

 17-05-2017, Der vermeintliche Feind auf dem Teller, Medical Tribune

 26-04-2017, Unverträglichkeiten: Mehr Hysterie als Sorge, Wiener Zeitung

 26-04-2017, Intoleranzen: Experten warnen vor unseriösen Angeboten, Kurier

 27-04-2017, Übel an der Wurzel packen, Neues Land

 27-04-2017, Das Geschäft mit der Intoleranz, Neue Vorarlberger Tageszeitung

 26-04-2017, Das Geschäft mit der Intoleranz, Kleine Zeitung

 25-04-2017, IgE & IgG Ein Buchstabe macht den großen Unterschied, IGAV

 25-04-2017, Warum IgE und nicht IgG:Ein kleines Detail mit enormer Auswirkung, Presseinterview

 06-03-2017, Eine Überreaktion des Immunsystems, Kurier

1.5.2 Research Awards: n = 10

Manuel Reithofer:

 Poster Award: 8th Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 19, 2017

 Presentation Prize: Joint Symposium of 2 PhD Programs, September 25-26, 2017

Dominika Polak:

 European Academy of Allergy and Clinical Immunology Annual Congress, 17-21 June 2017, Helsinki, Finland, “Human neutrophils process and present antigens to CD4+ T cells.”, prize for the ePoster presentation

 European Academy of Allergy and Clinical Immunology Annual Congress, 17-21 June 2017, Helsinki, Finland, “Human neutrophils process and present antigens to CD4+ T cells”, travel grant

 8th Retreat of the Centre for Pathophysiology, Infectiology and Immunology, September, 2017, Vienna, Austria, , “Neutrophils promote allergic inflammation by presenting allergen to specific CD4+ T cells.”, prize for the poster presentation

 SFB/MCCA retreat, November 2017, Ottenstein, Austria, “Neutrophils acquire antigen-presenting capacity in allergic late-phase responses.” prize for the poster presentation

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Gabriela Sánchez Acosta

 European Academy of Allergy and Clinical Immunology Annual Congress, 17-21 June 2017, Helsinki, Finland, “Antibody responses to sublingual treatment with recombinant Bet v 1 and Mal d 1”, poster prize at the Junior Member and Affiliates Poster Session

 IAI/MCCA PhD Joint PhD-Student Symposium – “Together One Step Further”, 25-26 September 2017, Vienna, Austria, “Allergen-specific antibody responses to sublingual treatment with recombinant Mal d 1 and Bet v 1”, best poster presentation prize

 Austrian Society for Allergology and Immunology annual meeting (ÖGAI), 23-25 November 2017, Vienna, Austria, best poster presentation prize

1.5.3. Invited lectures: n = 7

Barbara Bohle

 01.02.2017, Apples can drive birch pollen-allergic patients nuts! Novel insights into cross-reactivity of allergens. Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg  14.03.2017, Apples can drive birch pollen-allergic patients nuts! New insights into cross-reactivity of allergens. ICA – Seminar, University of Salzburg.  06.05.2017, Wie funktioniert Immuntherapie? Eine Einleitung. Allergie in Wien, DFB, Wien,.  10.05.2017, Spezifische Immuntherapie: Quo vadis? Interdisziplinärer Wiener Allergietag, MUW, JHS  18.06.2017, Bregs are as important as Tregs for allergen tolerance? EAACI Congress, Helsinki  06.09.2017, Recombinant Allergens for the Treatment of Pollen-Related Food Allergy, in a session on “Novel Forms of Allergen Immunotherapy”. 15. Paul Ehrlich Seminar, Bad Homburg, D.

1.5.4. Congress organization

Division member National congress Intern. Congress, Name: Name, date Function Name, date Function Barbara Bohle ÖGAI Annual President Meeting 2017 23. – 25. 11. 2017 Manuel Reithofer Joint Symposium of Public 2 PhD Programs, Relation September 25-26, 2017: TOGETHER ONE STEP FURTHER Gabriela Sánchez IAI/MCCA PhD Joint Sponsoring Acosta PhD-Student committee Symposium – “Together One Step 134

Performance Report 2017 – Division 6 Experimental Allergology

Further”, 25-26 September 2017, Vienna, Austria

1.5.5. Hosting speakers division member Speaker´s name Affiliation Date

1.5.6. Mobility

Name Program University, Time frame Division In Out Country Gabriela PhD program IAI: Philips University 3 months: 13 X Sánchez Inflammation And Marburg, Marburg, March 2017 – Acosta Immunity Germany 14th June 2017

1.5.7. Activities in Advisory Boards

Name Society/Institute/Journal Function Barbara Bohle Paul Ehrlich Institut, Langen, D Scientific advisor

1.5.8. Editorial Activities

Name Journal Function Bohle Barbara International Archives of allergy Editor in chief and Immunology

Bohle Barbara Clinical and Translational Allergy Editorial Board Member

Clinical and Experimental Editorial Board Member Allergy Bohle Barbara Bohle Barbara Immunotherapy Editorial Board Member

Beatrice Jahn – Schmid Frontiers in Immunology- Review Editor Immunotherapies and Vaccines

1.5.9. Review Activities

Name Grants/Thesis/Habilitation

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1.5.10. Filed and granted patents

Name Patent

1.5.11. Grants

Funding agency Title of project Principal investigator BIOMAY Impfst. & Toleranzstrat. F Typ I Allerg. Barbara Bohle Projektnummer: Innenauftragsnummer: AP00086OFF FWF der Inflammation and Immunity. Barbara Bohle Wissenschaftsfonds, T cell responses in Type I allergy. Doktoratskolleg Projektnummer: DK APW01212FW FWF der Towards prevention and therapy of allergy, Barbara Bohle Wissenschaftsfonds, SFB the Immunological basis of clinical tolerance Projektnummer: to allergens. APF 04610 FW Lizenzeinn. Fresenius Barbara Bohle kabi GMBH PA648LI001 FWF der Molecular, cellular and clinical allergology. Barbara Bohle Wissenschaftsfonds, Projektnummer: DK W 1248-B13 ÖNB Immune mechanism induced by sublingual Barbara Bohle Jubiläumsfondsprojekt administration of recombinant Bet v 1 and 16620 Mal d 1 to birch pollen-allergic patients with associated apple allergy FWF der Molecular, cellular and clinical allergology. Beatrice Jahn-Schmid Wissenschaftsfonds, Doktoratskolleg Projektnummer: DK W 1248-B13

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1.5.12. Career Developments a) Habilitations: n = 0

b) Habilitations in progress: n = 1

Dr. Claudia Kitzmüller

c) Professorships: n = 0

1.5.13. Teaching a) Bachelor students: n = 0

b) Diploma, MDiploma and Master students: n = 0

c) PhD, MDSci, MD students: n = 6

Beatrice Jahn-Schmid

 01-10-2014 REITHOFER Manuel, PhD Thesis: Allergen-specific immunomodulation by CD8+ T cells, in progress

 12-06-2017 KARACS Jasmine, PhD Thesis: The effect of alum and monophosphoryl-Lipid A (MPLA) on human neutrophils in vitro, in progress

Barbara Bohle:

 01-10-2013 POLAK Dominika, PhD Thesis: The role of neutrophils in IgE- mediated allergy, in progress

 01-12-2014 SANCHEZ-ACOSTA Gabriela, PhD Thesis: The role of allergen-specific IgG antibodies in allergen-specific T cell responses, in progress

 01-10-2017 GRILO Joao Rodrigues, PhD Thesis: Allergen-specific antibody and T-cell responses to SLIT with rBet v 1 and rMal d 1, in progress

 03-07-2017 STROBL Maria Regina, PhD Thesis: Characterisation of the affinity of allergen- specific antibodies, in progress

1.5.14. Exams: n = 7

a) Oral examinations: n = 2 137

Performance Report 2017 – Division 6 Experimental Allergology

b) Diploma and Thesis-Examinations: n = 6

Barbara Bohle:

2017-02-27 ZULEHNER Nora, Mag., PhD thesis examination

2017-06-23 GSCHWANDEGGER Sandra, Diploma

2017-08-30 ZIMMANN Felix, Bacc.

2017-10-17 GROSCHOPF Alina, Diploma

2017-10-18 BÖLL Simone, Diploma

2017-11-27 GERSTMAYR Marianne, PhD thesis examination

Beatrice Jahn – Schmid:

2017-08-30 ZIMMANN Felix, Bacc.

2017-10-18 BÖLLSimone, Diploma

27-11-2017 GERSTMAYR Marianne, PhD thesis examination

c) Exam supervising: n = 1

1. 28-09-2017 SIP Aufsicht Beatrice Jahn – Schmid

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1.5.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2017 Bohle Barbara 4.00 2.00 648000 Anleitung zum wissenschaftlichen Arbeiten Bohle Barbara 2.00 2.00 648035 Journal Club und Progress Report Bohle Barbara 2.00 2.00 648036 Dissertantenseminar Ziele und Methoden der Allergologie Bohle Barbara 2.00 0.17 860201 IAI-Journal Club Bohle Barbara 2.00 2.00 860206 Dissertantenseminar: Ziele und Methoden der Allergologie Bohle Barbara 2.00 0.13 860220 Basisvorlesung Immunologie Bohle Barbara 2.00 0.13 861007 MCCA Journal Club Bohle Barbara 2.00 0.40 861011 MCCA Lecture, Thesis Seminar and Basic Course Series on T-cells and antigen-presenting cells Bohle Barbara 2.00 0.15 901929 IAI-Basic Seminars Jahn-Schmid Beatrice 2.00 0.13 861007 MCCA Journal Club Jahn-Schmid Beatrice 2.00 0.40 861011 MCCA Lecture, Thesis Seminar and Basic Course Series on T-cells and antigen-presenting cells Jahn-Schmid Beatrice 4.00 2.00 648000 Anleitung zum wissenschaftlichen Arbeiten Sum 11.51

WS 2017/18 Bohle Barbara 2.00 1.00 648000 Journal Club und Progress Report Bohle Barbara 2.00 1.00 648006 Dissertantenseminar Ziele und Methoden der Allergologie Bohle Barbara 4.00 2.00 648100 Anleitung zum wissenschaftlichen Arbeiten Bohle Barbara 2.00 0.13 861007 MCCA Journal Club Bohle Barbara 2.00 0.22 861110 MCCA Lecture, Thesis Seminar and Basic Course Series on Allergens Bohle Barbara 2.00 0.13 901929 IAI-Basic Seminars Bohle Barbara 2.00 2.00 902211 Dissertantenseminar: Ziele und Methoden der Allergologie Bohle Barbara 2.00 0.17 902241 IAI-Journal Club Bohle Barbara 2.00 2.00 902564 Journal Club und Progress Report Bohle Barbara 2.00 0.18 902920 Special Course: Basic techniques in molecular and cellular biology Bohle Barbara 2.00 0.18 860008 Special Course: Scientific Presentation Bohle Barbara 2.00 0.15 860021 JC Microbiome Research Jahn-Schmid Beatrice 2.00 1.00 648000 Journal Club und Progress Report Jahn-Schmid Beatrice 2.20 0.27 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder 139

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Jahn-Schmid Beatrice 1.00 1.00 902542 Grundlagen der Allergologie Jahn-Schmid Beatrice 2.00 0.13 861007 MCCA Journal Club Jahn-Schmid Beatrice 2.00 1.00 648006 Dissertantenseminar Ziele und Methoden der Allergologie Jahn-Schmid Beatrice 4.00 2.00 648100 Anleitung zum wissenschaftlichen Arbeiten Sum 14.65 Total sum SS+WS 26.16

140

Performance Report 2017 Rooms

141