1 G3BP1 Tethers the TSC Complex to Lysosomes and Suppresses Mtorc1 in the Absence 1 of Stress Granules 2 Mirja T. Prentzell1-4,*
bioRxiv preprint doi: https://doi.org/10.1101/2020.04.16.044081; this version posted October 29, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence 2 of stress granules 3 Mirja T. Prentzell1-4,*, Ulrike Rehbein2,5,*, Marti Cadena Sandoval2,6,*, Ann-Sofie De 4 Meulemeester7,*, Ralf Baumeister3,4,8, Laura Brohée9, Bianca Berdel1, Mathias Bockwoldt10, 5 Bernadette Carroll11, Andreas von Deimling12,, Constantinos Demetriades9,13, Gianluca 6 Figlia14,15, Alexander M. Heberle2,6, Ines Heiland10, Birgit Holzwarth3, Lukas A. Huber16,17, 7 Jacek Jaworski18, Katharina Kern1, Andrii Kopach18, Viktor I. Korolchuk19, Ineke van 't Land- 8 Kuper2,5, Matylda Macias18, Mark Nellist20, Stefan Pusch12, Michele Reil1, Anja Reintjes6, 9 Friederike Reuter1, Chloë Scheldeman7,21, Eduard Stefan6, Aurelio Teleman14,15, Omar Torres- 10 Quesada6, Saskia Trump22, Peter de Witte7, Teodor Yordanov16,23, Christiane A. Opitz1,24,|,§, 11 Kathrin Thedieck2,5,6,|,§ 12 13 1Brain Cancer Metabolism Group, German Consortium of Translational Cancer Research 14 (DKTK) & German Cancer Research Center (DKFZ), Heidelberg, Germany 15 2Department of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University 16 of Groningen, University Medical Center Groningen, The Netherlands 17 3Department
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