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PREVALENCE of NON-CYTOCHROME P450-MEDIATED METABOLISM in FDA APPROVED ORAL and INTRAVENOUS DRUGS: 2006 – 2015 Matthew A. Cern

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PREVALENCE of NON-CYTOCHROME P450-MEDIATED METABOLISM in FDA APPROVED ORAL and INTRAVENOUS DRUGS: 2006 – 2015 Matthew A. Cern Downloaded from dmd.aspetjournals.org at ASPET Journals on September 27, 2021 1 Matthew A.Cerny DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 APPROVED ORAL AND INTRAVENOUS DRUGS: 20062015– This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. 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This article has not been copyedited and formatted. The final version may differ from this version. Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Pfizer, Inc., Groton, CT CT Groton, Inc., Pfizer, Metabolism, Drug and Pharmacodynamics, Pharmacokinetics, PREVALENCE NON-CYTOCHROME OF P450-MEDIATED METABOLISM FDA IN DMD # 70763 # DMD DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 This article has not been copyedited and formatted. The final version may differ from this version. DMD # 70763 Running Title: Non-P450 Metabolism of FDA Approved Drugs: 2006 – 2015 Corresponding Author: Matthew A. Cerny, Pfizer, Inc., Groton, CT, 06340 [email protected] Number of: Text Pages: 20 Tables: 2 Figures: 5 Downloaded from References: 72 Number of Words in: dmd.aspetjournals.org Abstract: 242 Introduction: 1182 (942 with reference citations removed) Results and Discussion: 2115 at ASPET Journals on September 27, 2021 Abbreviations: CL, clearance; F, oral bioavailability; ADME, absorption, distribution, metabolism, and excretion; FDA, Food and Drug Administration; EMA; European Medicines Agency; P450, cytochrome P450; UGT, Uridine 5'-diphospho-glucuronosyltransferase; FMO, Flavin-containing monooxygenase; AO, aldehyde oxidase, XO, xanthine oxidase; MAO, monoamine oxidase; CBR, carbonyl reductase; AKR, aldo-keto reductase; ALDH, aldehyde dehydrogenase; ADH, alcohol dehydrogenase; NAT, N-acetyl transferase; GST, glutathione S- transferase; SULT, sulfotransferase; MT, methyltransferase; CES, carboxylesterase; NDA, New Drug Application; BLA, Biological License Application; ADC, antibody drug conjugate; DDI, drug-drug interaction. 2 DMD Fast Forward. Published on April 15, 2016 as DOI: 10.1124/dmd.116.070763 This article has not been copyedited and formatted. The final version may differ from this version.
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