ORIGINAL RESEARCH published: 22 April 2021 doi: 10.3389/fonc.2021.643104 TRIM68, PIKFYVE, and DYNLL2: The Possible Novel Autophagy- and Immunity-Associated Edited by: Gene Biomarkers for Simone Patergnani, University of Ferrara, Italy Osteosarcoma Prognosis Reviewed by: Jun Lyu, † † First Affiliated Hospital of Jinan Jie Jiang , Dachang Liu , Guoyong Xu, Tuo Liang, Chaojie Yu, Shian Liao, Liyi Chen, University, China Shengsheng Huang, Xuhua Sun, Ming Yi, Zide Zhang, Zhaojun Lu, Zequn Wang, Daniel Peña-Oyarzun, Jiarui Chen, Tianyou Chen, Hao Li, Yuanlin Yao, Wuhua Chen, Hao Guo, Chong Liu* Pontifical Catholic University of Chile, and Xinli Zhan* Chile Ushashi Dadwal, Department of Spinal Orthopedics, The First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China Indiana University, Purdue University Indianapolis, United States Introduction: Osteosarcoma is among the most common orthopedic neoplasms, and *Correspondence: Chong Liu currently, there are no adequate biomarkers to predict its prognosis. Therefore, the
[email protected] present study was aimed to identify the prognostic biomarkers for autophagy-and Xinli Zhan immune-related osteosarcoma using bioinformatics tools for guiding the clinical
[email protected] † diagnosis and treatment of this disease. These authors have contributed equally to this work and Materials and Methods: The gene expression and clinical information data were share first authorship downloaded from the Public database. The genes associated with autophagy were Specialty section: extracted, followed by the development of a logistic regression model for predicting the This article was submitted to prognosis of osteosarcoma using univariate and multivariate COX regression analysis and Molecular and Cellular Oncology, fi a section of the journal LASSO regression analysis.