DOCSLIB.ORG

Biological Activity and Applications of Natural Compounds and Applications  Biological Activity

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Biological Activity and Applications of Natural Compounds and Applications  Biological Activity Biological Activity Biological and Applications Natural Compounds of • Ana M. L. Seca, Laila and Sharopov Moujir Moujir Farukh Biological Activity and Applications of Natural Compounds Edited by Ana M. L. Seca, Laila Moujir Moujir and Farukh Sharopov Printed Edition of the Special Issue Published in Applied Sciences www.mdpi.com/journal/applsci Biological Activity and Applications of Natural Compounds Biological Activity and Applications of Natural Compounds Editors Ana M. L. Seca Laila Moujir Moujir Farukh Sharopov MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade • Manchester • Tokyo • Cluj • Tianjin Special Issue Editor Ana M. L. Seca Laila Moujir Moujir Farukh Sharopov cE3c/GBA, FCT—University of Departamento de Bioqu´ımica, Research Institution Azores, Ponta Delgada Microbiolog´ıa, Genetica´ y “Chinese-Tajik Innovation Portugal Biologia Celular, Center for Natural Products”, Facultad de Farmacia, Academy of Sciences of the Universidad de La Laguna Republic of Tajikistan, Spain Rudaki Avenue 33, Dushanbe Tajikistan Editorial Office MDPI St. Alban-Anlage 66 4052 Basel, Switzerland This is a reprint of articles from the Special Issue published online in the open access journal Applied Sciences (ISSN 2076-3417) (available at: https://www.mdpi.com/journal/applsci/special issues/activity natural compounds). For citation purposes, cite each article independently as indicated on the article page online and as indicated below: LastName, A.A.; LastName, B.B.; LastName, C.C. Article Title. Journal Name Year, Article Number, Page Range. ISBN 978-3-03936-617-0 (Hbk) ISBN 978-3-03936-618-7 (PDF) c 2020 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND. Contents About the Editors .............................................. vii Ana M. L. Seca and Laila Moujir Natural Compounds: A Dynamic Field of Applications Reprinted from: Applsci 2020, 10, 4025, doi:10.3390/app10114025 ................... 1 Jos´e Weverton Almeida Bezerra, Felicidade Caroline Rodrigues, Rafael Pereira da Cruz, Luiz Everson da Silva, Wanderlei do Amaral, Ricardo Andrade Rebelo, Ieda Maria Begnini, Camila Fonseca Bezerra, Marcello Iriti, Elena Maria Varoni, Henrique Douglas Melo Coutinho and Maria Flaviana Bezerra Morais-Braga Antibiotic Potential and Chemical Composition of the Essential Oil of Piper caldense C. DC. (Piperaceae) Reprinted from: Applsci 2020, 10, 631, doi:10.3390/app10020631 ................... 9 Sims K. Lawson, Layla G. Sharp, Chelsea N. Powers, Robert L. McFeeters, Prabodh Satyal and William N. Setzer Essential Oil Compositions and Antifungal Activity of Sunflower (Helianthus) Species Growing in North Alabama Reprinted from: Applsci 2019, 9, 3179, doi:10.3390/app9153179 .................... 21 Chunpeng Wan, Yuting Shen, Muhammad Farrukh Nisar, Wenwen Qi, Chuying Chen and Jinyin Chen The Antifungal Potential of Carvacrol against Penicillium Digitatum through 1H-NMR Based Metabolomics Approach Reprinted from: Applsci 2019, 9, 2240, doi:10.3390/app9112240 .................... 29 Laila Moujir, Manuel R. L´opez, Carolina P. Reyes, Ignacio A. Jim´enez and Isabel L. Bazzocchi Structural Requirements for Antimicrobial Activity of Phenolic Nor-Triterpenes from Celastraceae Species Reprinted from: Applsci 2019, 9, 2957, doi:10.3390/app9152957 .................... 41 Jeong A Yoon, Changjin Lim, Dong Seok Cha and Young Taek Han Synthesis and Evaluation of the Lifespan-Extension Properties of Oleracones D–F, Antioxidative Flavonoids from Portulaca oleracea L. Reprinted from: Applsci 2019, 9, 4014, doi:10.3390/app9194014 .................... 53 Duangjai Tungmunnithum, Ahmed Elamrani, Malika Abid, Samantha Drouet, Reza Kiani, Laurine Garros, Atul Kabra, Mohamed Addi and Christophe Hano A Quick, Green and Simple Ultrasound-Assisted Extraction for the Valorization of Antioxidant Phenolic Acids from Moroccan Almond Cold-Pressed Oil Residues Reprinted from: Applsci 2020, 10, 3313, doi:10.3390/app10093313 ................... 61 Bohyung Kang, Sullim Lee, Chang-Seob Seo, Ki Sung Kang and You-Kyung Choi Analysis and Identification of Active Compounds from Salviae miltiorrhizae Radix Toxic to HCT-116 Human Colon Cancer Cells Reprinted from: Applsci 2020, 10, 1304, doi:10.3390/app10041304 ................... 81 Gon¸calo P. Rosa, Ana M. L. Seca, Maria do Carmo Barreto, Artur M. S. Silva and Diana C. G. A. Pinto Chalcones and Flavanones Bearing Hydroxyl and/or Methoxyl Groups: Synthesis and Biological Assessments Reprinted from: Applsci 2019, 9, 2846, doi:10.3390/app9142846 .................... 91 v Sodik Numonov, Farukh S. Sharopov, Sunbula Atolikhshoeva, Abduahad Safomuddin, Mahinur Bakri, William N. Setzer, Azizullo Musoev, Mizhgona Sharofova, Maidina Habasi and Haji Akber Aisa Volatile Secondary Metabolites with Potent Antidiabetic Activity from the Roots of Prangos pabularia Lindl.—Computational and Experimental Investigations Reprinted from: Applsci 2019, 9, 2362, doi:10.3390/app9112362 ....................109 Alexandra M. Afonso, Joana Gon¸calves, Angeloˆ Lu´ıs, Eugenia Gallardo and Ana Paula Duarte Evaluation of the In Vitro Wound-Healing Activity and Phytochemical Characterization of Propolis and Honey Reprinted from: Applsci 2020, 10, 1845, doi:10.3390/app10051845 ...................127 Laila Moujir, Oliver Callies, Pedro M. C. Sousa, Farukh Sharopov and Ana M. L. Seca Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases Reprinted from: Applsci 2020, 10, 3001, doi:10.3390/app10093001 ...................141 Muhammad Nadeem, Muhammad Imran, Tanweer Aslam Gondal, Ali Imran, Muhammad Shahbaz, Rai Muhammad Amir, Muhammad Wasim Sajid, Tahira Batool Qaisrani, Muhammad Atif, Ghulam Hussain, Bahare Salehi, Elise Adrian Ostrander, Miquel Martorell, Javad Sharifi-Rad, William C. Cho and Nat´alia Martins Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review Reprinted from: Applsci 2019, 9, 3139, doi:10.3390/app9153139 ....................173 vi About the Editors Ana M. L. Seca has a degree in Chemistry and an MSc in the Science and Technology of Paper and Forest Products, both obtained at the University of Aveiro, Portugal, where she also completed her PhD in Chemistry in 2000. Since then, she has worked as an assistant professor at the University of Azores (Portugal) and, since 2016, has been a member of the Center for Ecology, Evolution and Environmental Changes—cE3c (ABG). She has published 48 SCI papers and 8 book chapters. Her current research interests range from the isolation and identification of secondary metabolites with potential pharmacological applications to the synthesis of pharmaceutically relevant natural compound analogues. Laila Moujir Moujir has a degree in Pharmacy from the University of La Laguna, Spain, where she also completed her PhD in Microbiology in 1988. She was granted a diploma in Health and specialized in Clinical Analysis. She was a postdoctoral fellow at the University of British Columbia (Canada) and at the Molecular Biology Center (CBM) Madrid. In 2006, she started working as an associate professor at the Department of Microbiology and Biology Cell of the University of La Laguna. During her research career, she has published more than 50 papers within her field of research, “Search and selection of antimicrobials, cytostatic and antivirals of natural products”. Farukh Sharopov completed his Doctor of Sciences degree in Natural Sciences at Ruprecht Karls University in Heidelberg, Germany, in 2015. From 2018, he has been a postdoctoral researcher at the Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (China), and at the same time, he is a researcher at the research institution Chinese-Tajik Innovation Center for Natural Products, National Academy of Sciences of the Republic of Tajikistan. He is the author of more than 100 research papers. His research interests are natural products, drug delivery and surface chemistry. vii applied sciences Editorial Natural Compounds: A Dynamic Field of Applications Ana M. L. Seca 1,2,* and Laila Moujir 3 1 cE3c-Centre for Ecology, Evolution and Environmental Changes/Azorean Biodiversity Group & Faculty of Sciences and Technology, University of Azores, Rua Mãe de Deus, 9500-321 Ponta Delgada, Portugal 2 LAQV-REQUIMTE, University of Aveiro, 3810-193 Aveiro, Portugal 3 Department of Biochemistry, Microbiology, Genetics and Cell Biology, Facultad de Farmacia, Universidad de La Laguna, 38206 San Cristóbal de La Laguna, Spain; [email protected] * Correspondence: [email protected]; Tel.: +351-29-6650174 Received: 2 June 2020; Accepted: 7 June 2020; Published: 10 June 2020 Abstract: Nature represents an amazing source of inspiration since it produces a great diversity of natural compounds selected by evolution, which exhibit multiple biological activities and applications. A large and very active research field is dedicated to identifying biosynthesized compounds, to improve/develop new methodologies to produce/reuse natural compounds and to assess their potential for pharmaceutical, cosmetic and food industries, among others, and also to understand their mechanism of action. Here, the main results presented in each work are highlighted. The applications
Load more

Recommended publications
  • Baicalin Promotes the Viability of Schwann Cells in Vitro by Regulating Neurotrophic Factors
    EXPERIMENTAL AND THERAPEUTIC MEDICINE 14: 507-514, 2017 Baicalin promotes the viability of Schwann cells in vitro by regulating neurotrophic factors WENPU ZUO1*, HUAYU WU2*, KUN ZHANG3,4, PEIZHEN LV3,4, FUBEN XU1,5, WEIZHE JIANG6, LI ZHENG1,5 and JINMIN ZHAO3-5 1Medical and Scientific Research Center;2 Department of Cell Biology and Genetics, School of Premedical Sciences; 3Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University; 4Department of Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University;5 Key Laboratory of Regenerative Medicine of Guangxi High School; 6Department of Pharmacology, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China Received January 20, 2016; Accepted February 14, 2017 DOI: 10.3892/etm.2017.4524 Abstract. The proliferation and migration of Schwann of baicalin exhibited the greatest cell viability and gene cells (SCs) are key events in the process of peripheral nerve expression of the studied neurotrophic factors. The present repair. This is required to promote the growth of SCs and is findings suggested that baicalin likely affects SCs metabo- a challenge during the treatment of peripheral nerve injury. lism, through modulating the expression of neurotrophic Baicalin is a natural herb‑derived flavonoid compound, which factors. To conclude, the present study indicates that baicalin has been reported to possess neuroprotective effects on rats may be potential therapeutic agent for treating peripheral with permanent brain ischemia and neuronal differentiation nerve regeneration. of neural stem cells. The association of baicalin with neuro- protection leads to the suggestion that baicalin may exert Introduction effects on the growth of SCs.
    [Show full text]
  • The Antidepressant Effect of Testosterone an Effect Of
    Neurology, Psychiatry and Brain Research 32 (2019) 104–110 Contents lists available at ScienceDirect Neurology, Psychiatry and Brain Research journal homepage: www.elsevier.com/locate/npbr The antidepressant effect of testosterone: An effect of neuroplasticity? T ⁎ Andreas Walthera,b,c, , Joanna Marta Wasielewskad, Odette Leitere a Biological Psychology, Technische Universität Dresden, Dresden, Germany b Clinical Psychology and Psychotherapy, University of Zurich, Zurich, Switzerland c Task Force on Men’s Mental Health of the World Federation of the Societies of Biological Psychiatry (WFSBP), Germany d Center for Regenerative Therapies (CRTD), Technische Universität Dresden, Germany e Queensland Brain Institute (QBI), University of Queensland, St Lucia, QLD, 4072, Australia ARTICLE INFO ABSTRACT Keywords: Background: Rodent and human studies indicate that testosterone has an antidepressant effect. The mechanisms Testosterone via which testosterone exerts its antidepressant effect, however, remain to be elucidated. Some studies assume Depression downstream effects of testosterone on sexual function and vitality followed by improvement of mood. Emerging Men evidence suggests that testosterone may be acting in the brain within depression-relevant areas, whereby eli- Neurogenesis citing direct antidepressant effects, potentially via neuroplasticity. Neuroplasticity Methods: Literature was searched focusing on testosterone treatment and depression and depression-like be- Antidepressant havior. Due to the unilateral clinical use of testosterone in men and the different modes of action of sex hor- mones in the central nervous system in men and women, predominantly studies on male populations were identified. Results: The two proposed mechanisms via which testosterone might act as antidepressant in the central nervous system are the support of neuroplasticity as well as the activation of the serotonin system.
    [Show full text]
  • Mechanism of the Inhibitory Effect of Antiinflammatory Baicalin on Airway Reconstruction in COPD Rats
    Research Paper Mechanism of the Inhibitory Effect of Antiinflammatory Baicalin on Airway Reconstruction in COPD Rats J. QIU, W. GONG AND J. DONG* Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Wulumiqi Road, Shanghai, China Qiu et al.: Mechanism of baicalin in inhibiting airway reconstruction in COPD rats The mechanism of baicalin in airway reconstruction in rats with chronic obstructive pulmonary disease was investigated. The chronic obstructive pulmonary disease models were established in rats through smoke inhalation and instilling lipopolysaccharide. The rats were then divided into the control group and the experimental group, a blank group was used as a reference point of the experiment. Rats in the experiment group received baicalin either at a high dose (80 mg/kg/d, H1) or at a low dose (25 mg/kg/d, H2) to analyse the airway reconstruction functions and antiinflammatory effects of baicalin. During the experiment, the general conditions of the rats were compared. After the experiment, lung tissues of the rats were obtained for Hematoxylin-Eosin staining, and the pathological changes were observed. In addition, the bronchial walls were measured and analysed. Using immunohistochemical staining, the expression levels of tumour necrosis factor-α and interferon-γ in rat lung tissues were analysed and compared. Hematoxylin-Eosin staining of lung tissues showed that the rats with chronic obstructive pulmonary disease had severe pathological damages; compared to the blank group, while in rats treated with baicalin, bronchial obstruction, alveolar structure and inflammatory infiltration were improved, and the differences were statistically significant (p<0.05). After baicalin administration, the bronchial wall thickness in chronic obstructive pulmonary disease rats was reduced, collagen deposition in the bronchial epithelium was improved, and airway smooth muscle proliferation was alleviated compared to the control group.
    [Show full text]
  • Novel Bioactive Extraction and Nano-Encapsulation
    Entry Novel Bioactive Extraction and Nano-Encapsulation Shaba Noore 1,2 , Navin Kumar Rastogi 3, Colm O’Donnell 2 and Brijesh Tiwari 1,2,* 1 Department of Food Chemistry & Technology, Teagasc Food Research Centre, Ashtown, D15 DY05 Dublin, Ireland; [email protected] 2 School of Biosystems and Food Engineering, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland; [email protected] 3 Department of Food Engineering, CSIR-Central Food Technological Research Institute, Mysuru 570020, India; [email protected] * Correspondence: [email protected] Definition: An extraction technology works on the principle of two consecutive steps that involves mixture of solute with solvent and the movement of soluble compounds from the cell into the solvent and its consequent diffusion and extraction. The conventional extraction techniques are mostly based on the use of mild/high temperatures (50–90 ◦C) that can cause thermal degradation, are dependent on the mass transfer rate, being reflected on long extraction times, high costs, low extraction efficiency, with consequent low extraction yields. Due to these disadvantages, it is of interest to develop non-thermal extraction methods, such as microwave, ultrasounds, supercritical fluids (mostly using carbon dioxide, SC-CO2), and high hydrostatic pressure-assisted extractions which works on the phenomena of minimum heat exposure with reduced processing time, thereby minimizing the loss of bioactive compounds during extraction. Further, to improve the stability of these extracted compounds, nano-encapsulation is required. Nano-encapsulation is a process which forms a thin layer of protection against environmental degradation and retains the nutritional and Citation: Noore, S.; Rastogi, N.K.; functional qualities of bioactive compounds in nano-scale level capsules by employing fats, starches, O’Donnell, C.; Tiwari, B.
    [Show full text]
  • 2018 Apigenin Male Infertility (2).Pdf
    Original Article Thai Journal of Pharmaceutical Sciences Apigenin and baicalin, each alone or in low-dose combination, attenuated chloroquine induced male infertility in adult rats Amira Akilah, Mohamed Balaha*, Mohamed-Nabeih Abd-El Rahman, Sabiha Hedya Department of Pharmacology, Faculty of Medicine, Tanta University, Postal No. 31527, El-Gish Street, Tanta, Egypt Corresponding Author: Department of Pharmacology, ABSTRACT Faculty of Medicine, Tanta University, Postal No. 31527, Introduction: Male infertility is a worldwide health problem, which accounts for about 50% of all El-Gish Street, Tanta, Egypt. cases of infertility and considered as the most common single defined cause of infertility. Recently, Tel.: +201284451952. E-mail: apigenin and baicalin exhibited a powerful antioxidant and antiapoptotic activities. Consequently, in [email protected]. the present study, we evaluated the possible protective effect of apigenin and baicalin, either alone or Edu.Eg (M. Balaha). in low-dose combination, on a rat model of male infertility, regarding for its effects on the hormonal assay, testicular weight, sperm parameters, oxidative-stress state, apoptosis, and histopathological Received: Mar 06, 2018 changes. Material and methods: 12-week-old adult male Wister rats received 10 mg/kg/d Accepted: May 08, 2018 chloroquine orally for 30 days to induce male infertility. Either apigenin (30 or 15 mg/kg/d), baicalin Published: July 10, 2018 (100 or 50 mg/kg/d) or a combination of 15 mg/kg/d apigenin and 50 mg/kg/d baicalin received daily
    [Show full text]
  • Biosynthesis of New Alpha-Bisabolol Derivatives Through a Synthetic Biology Approach Arthur Sarrade-Loucheur
    Biosynthesis of new alpha-bisabolol derivatives through a synthetic biology approach Arthur Sarrade-Loucheur To cite this version: Arthur Sarrade-Loucheur. Biosynthesis of new alpha-bisabolol derivatives through a synthetic biology approach. Biochemistry, Molecular Biology. INSA de Toulouse, 2020. English. NNT : 2020ISAT0003. tel-02976811 HAL Id: tel-02976811 https://tel.archives-ouvertes.fr/tel-02976811 Submitted on 23 Oct 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. THÈSE En vue de l’obtention du DOCTORAT DE L’UNIVERSITÉ DE TOULOUSE Délivré par l'Institut National des Sciences Appliquées de Toulouse Présentée et soutenue par Arthur SARRADE-LOUCHEUR Le 30 juin 2020 Biosynthèse de nouveaux dérivés de l'α-bisabolol par une approche de biologie synthèse Ecole doctorale : SEVAB - Sciences Ecologiques, Vétérinaires, Agronomiques et Bioingenieries Spécialité : Ingénieries microbienne et enzymatique Unité de recherche : TBI - Toulouse Biotechnology Institute, Bio & Chemical Engineering Thèse dirigée par Gilles TRUAN et Magali REMAUD-SIMEON Jury
    [Show full text]
  • Isolation, Identification and Characterization of Allelochemicals/Natural Products
    Isolation, Identification and Characterization of Allelochemicals/Natural Products Isolation, Identification and Characterization of Allelochemicals/Natural Products Editors DIEGO A. SAMPIETRO Instituto de Estudios Vegetales “Dr. A. R. Sampietro” Universidad Nacional de Tucumán, Tucumán Argentina CESAR A. N. CATALAN Instituto de Química Orgánica Universidad Nacional de Tucumán, Tucumán Argentina MARTA A. VATTUONE Instituto de Estudios Vegetales “Dr. A. R. Sampietro” Universidad Nacional de Tucumán, Tucumán Argentina Series Editor S. S. NARWAL Haryana Agricultural University Hisar, India Science Publishers Enfield (NH) Jersey Plymouth Science Publishers www.scipub.net 234 May Street Post Office Box 699 Enfield, New Hampshire 03748 United States of America General enquiries : [email protected] Editorial enquiries : [email protected] Sales enquiries : [email protected] Published by Science Publishers, Enfield, NH, USA An imprint of Edenbridge Ltd., British Channel Islands Printed in India © 2009 reserved ISBN: 978-1-57808-577-4 Library of Congress Cataloging-in-Publication Data Isolation, identification and characterization of allelo- chemicals/natural products/editors, Diego A. Sampietro, Cesar A. N. Catalan, Marta A. Vattuone. p. cm. Includes bibliographical references and index. ISBN 978-1-57808-577-4 (hardcover) 1. Allelochemicals. 2. Natural products. I. Sampietro, Diego A. II. Catalan, Cesar A. N. III. Vattuone, Marta A. QK898.A43I86 2009 571.9’2--dc22 2008048397 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying or otherwise, without the prior permission of the publisher, in writing. The exception to this is when a reasonable part of the text is quoted for purpose of book review, abstracting etc.
    [Show full text]
  • Single Laboratory Validation of a Quantitative Core Shell-Based LC
    Single Laboratory Validation of a Quantitative Core Shell-Based LC Separation for the Evaluation of Silymarin Variability and Associated Antioxidant Activity of Pakistani Ecotypes of Milk Thistle (Silybum Marianum L.) Samantha Drouet, Bilal Haider Abbasi, Annie Falguieres, Waqar Ahmad, S. Sumaira, Clothilde Ferroud, Joël Doussot, Jean Vanier, Christophe Hano To cite this version: Samantha Drouet, Bilal Haider Abbasi, Annie Falguieres, Waqar Ahmad, S. Sumaira, et al.. Single Laboratory Validation of a Quantitative Core Shell-Based LC Separation for the Evaluation of Sily- marin Variability and Associated Antioxidant Activity of Pakistani Ecotypes of Milk Thistle (Silybum Marianum L.). Molecules, MDPI, 2018, 23 (4), pp.904. 10.3390/molecules23040904. hal-02538464 HAL Id: hal-02538464 https://hal.archives-ouvertes.fr/hal-02538464 Submitted on 9 Apr 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution| 4.0 International License molecules Article Single Laboratory Validation of a Quantitative Core Shell-Based
    [Show full text]
  • Total Phenolic Content, Free Radical Scavenging Capacity, and Anti- Cancer Activity of Silymarin
    Journal of International Society for Food Bioactives Nutraceuticals and Functional Foods Review J. Food Bioact. 2020;10:53–63 Total phenolic content, free radical scavenging capacity, and anti- cancer activity of silymarin Uyory Choea, Monica Whenta*, Yinghua Luob and Liangli Yua aDepartment of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA bCollege of Food Science and Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Ministry of Educa- tion, China Agricultural University, Beijing, China *Corresponding author: Monica Whent, Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA. Tel: +1 301 4054521; E-mail: [email protected] DOI: 10.31665/JFB.2020.10227 Received: June 19, 2020; Revised received & accepted: June 29, 2020 Citation: Choe, U., Whent, M., Luo, Y., and Yu, L. (2020). Total phenolic content, free radical scavenging capacity, and anti-cancer activity of silymarin. J. Food Bioact. 10: 53–63. Abstract Milk thistle (Silybum marianum) seeds are a good source of dietary polyphenols. The bioactive component of milk thistle seeds, silymarin, contains flavonolignans including silybin A, silybin B, isosilybin A, isosilybin B, sily- christin, isosilychristin, and silydiain along with the flavonol taxifolin. Silymarin is used traditionally as a natural herbal medicine with minimal side effects. Structurally, each silymarin component possesses phenolic hydroxyl groups and thus works as an antioxidant. In addition to free radical scavenging capacities, silymarin’s anti-cancer activities were reported for many different types of cancers including bladder, breast, colon, gastric, kidney, lung, oral, ovarian, prostate, and skin. The current review will discuss silymarin’s chemical components, total phenolic content, free radical scavenging capacities, and anti-cancer activities.
    [Show full text]
  • The Biosynthesis of Sesquiterpene Lactones in Chicory (Cichorium Intybus L.) Roots Promotor Prof
    The Biosynthesis of Sesquiterpene Lactones in Chicory (Cichorium intybus L.) Roots Promotor Prof. dr. Æ. de Groot, hoogleraar in de bio-organische chemie, Wageningen Universiteit Co-promotoren Dr. M.C.R. Franssen, universitair hoofddocent, Laboratorium voor Organische Chemie, Wageningen Universiteit Dr. ir. H.J. Bouwmeester, senior onderzoeker, Business Unit Celcybernetica, Plant Research International Promotiecommissie Prof. dr. J. Gershenzon (Max Planck Institute for Chemical Ecology, Germany) Prof. dr. L.H.W. van der Plas (Wageningen Universiteit) Prof. dr. ir. I.M.C.M. Rietjens (Wageningen Universiteit) Prof. dr. E.J.R. Sudhölter (Wageningen Universiteit) Jan-Willem de Kraker The Biosynthesis of Sesquiterpene Lactones in Chicory (Cichorium intybus L.) Roots Proefschrift ter verkrijging van de graad van doctor op gezag van de rector magnificus van Wageningen Universiteit prof. dr. ir. L. Speelman in het openbaar te verdedigen op woensdag 9 januari 2002 des namiddags te vier uur in de Aula de Kraker, J.-W. The Biosynthesis of Sesquiterpene Lactones in Chicory (Cichorium intybus L.) Roots Thesis Wageningen University – with summaries in English and Dutch ISBN 90-5808-531-7 Voorwoord — Preface De afgelopen vijf jaar was het voor mij witlof, dag in dag uit. Waarschijnlijk is dit ook de reden dat ik al ruim 3 jaar geen witlof meer kan ruiken, laat staan eet. Als je dan ongeacht waar je in Europa bent overal in de wegberm uitsluitend blauwe bloemen ziet opduiken, is het wel goed en verstandig er eens een punt achter te zetten. Hoewel het eind van dit promotie- onderzoek door al het ‘wachtgeldgedoe’ en bijbehorende ‘dode mussen’ wel erg abrupt en weinig chique kwam, kan ik me nu met goed gevoel weer eens op wat anders storten.
    [Show full text]
  • Original Article Hispidulin Induces Mitochondrial Apoptosis in Acute Myeloid Leukemia Cells by Targeting Extracellular Matrix Metalloproteinase Inducer
    Am J Transl Res 2016;8(2):1115-1132 www.ajtr.org /ISSN:1943-8141/AJTR0014691 Original Article Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer Hui Gao1*, Yongji Liu2*, Kan Li3, Tianhui Wu4, Jianjun Peng5, Fanbo Jing6 1Qingdao University Medical College, Qingdao, Shandong, 266071, China; 2Qingdao Hiser Medical Center, Qingdao, Shandong 266000, China; 3Shandong Provincial Hospital Affiliated to Shandong University, Shandong 250021, China; 4Qingdao 5th People’s Hospital, Qingdao, Shandong 266000, China; 5College of Life Sciences, Chongqing Normal University, Chongqing 401331, China; 6The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China. *Equal contributors. Received August 18, 2015; Accepted January 12, 2016; Epub February 15, 2016; Published February 29, 2016 Abstract: Acute myeloid leukemia (AML) represents a heterogeneous group of hematological neoplasms with marked heterogeneity in response to both standard therapy and survival. Hispidulin, a flavonoid compound that is anactive ingredient in the traditional Chinese medicinal herb Salvia plebeia R. Br, has recently been reported to have anantitumor effect against solid tumors in vitro and in vivo. The aim of the present study was to investigate the effects of hispidulin on the human leukemia cell line in vitro and the underlying mechanisms of its actions on these cells. Our results showed that hispidulin inhibits AML cell proliferation in a dose- and time-dependent man- ner, and induces cell apoptosis throughan intrinsic mitochondrial pathway. Our results also revealed that hispidulin treatment significantly inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) expression in both tested AML cell lines in a dose-dependent manner, and that the overexpression of EMMPRIN protein markedly attenuates hispidulin-induced cell apoptosis.
    [Show full text]
  • Ameliorative Effects of a Combination of Baicalin, Jasminoidin and Cholic Acid on Ibotenic Acid-Induced Dementia Model in Rats
    Ameliorative Effects of a Combination of Baicalin, Jasminoidin and Cholic Acid on Ibotenic Acid-Induced Dementia Model in Rats Junying Zhang1,2, Peng Li3., Yanping Wang4., Jianxun Liu3, Zhanjun Zhang2*, Weidong Cheng1*, Yongyan Wang4 1 School of Basic Medical Sciences, Lanzhou University, Lanzhou, P. R. China, 2 State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, P. R. China, 3 The Laboratory Research Center of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, P. R. China, 4 The Institute of Basic Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, P. R. China Abstract Aims: To investigate the therapeutic effects and acting mechanism of a combination of Chinese herb active components, i.e., a combination of baicalin, jasminoidin and cholic acid (CBJC) on Alzheimer’s disease (AD). Methods: Male rats were intracerebroventricularly injected with ibotenic acid (IBO), and CBJC was orally administered. Therapeutic effect was evaluated with the Morris water maze test, FDG-PET examination, and histological examination, and the acting mechanism was studied with DNA microarrays and western blotting. Results: CBJC treatment significantly attenuated IBO-induced abnormalities in cognition, brain functional images, and brain histological morphology. Additionally, the expression levels of 19 genes in the forebrain were significantly influenced by CBJC; approximately 60% of these genes were related to neuroprotection and neurogenesis, whereas others were related to anti-oxidation, protein degradation, cholesterol metabolism, stress response, angiogenesis, and apoptosis. Expression of these genes was increased, except for the gene related to apoptosis. Changes in expression for 5 of these genes were confirmed by western blotting. Conclusion: CBJC can ameliorate the IBO-induced dementia in rats and may be significant in the treatment of AD.
    [Show full text]