Attenuated Pfspz Vaccine Induces Strain-Transcending T Cells and Durable Protection Against Heterologous Controlled Human Malaria Infection
Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection Kirsten E. Lykea,1, Andrew S. Ishizukab,1, Andrea A. Berrya, Sumana Chakravartyc, Adam DeZureb, Mary E. Enamab, Eric R. Jamesc, Peter F. Billingsleyc, Anusha Gunasekerac, Anita Manojc, Minglin Lic,d, Adam J. Rubenc, Tao Lic, Abraham G. Eappenc, Richard E. Staffordc,d, Natasha KCc,d, Tooba Murshedkarc, Floreliz H. Mendozab, Ingelise J. Gordonb, Kathryn L. Zephirb, LaSonji A. Holmanb, Sarah H. Plummerb, Cynthia S. Hendelb, Laura Novikb, Pamela J. M. Costnerb, Jamie G. Saundersb, Nina M. Berkowitzb, Barbara J. Flynnb, Martha C. Nasone, Lindsay S. Garverf, Matthew B. Laurensa, Christopher V. Plowea, Thomas L. Richiec, Barney S. Grahamb, Mario Roedererb, B. Kim Lee Simc,d, Julie E. Ledgerwoodb, Stephen L. Hoffmanc,2, and Robert A. Sederb,2,3 aCenter for Vaccine Development and Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore,MD 21201; bVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; cSanaria Inc., Rockville, MD 20850; dProtein Potential LLC, Rockville, MD 20850; eBiostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and fEntomology Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910 Edited by Louis H. Miller, NIH, Rockville, MD, and approved January 19, 2017 (received for review September 27, 2016) A live-attenuated malaria vaccine, Plasmodium falciparum sporo- schedule showed a 26% and 36% reduction in clinical malaria zoite vaccine (PfSPZ Vaccine), confers sterile protection against among 6–12-wk-olds and 5–17-mo-olds, respectively, through 3–4y controlled human malaria infection (CHMI) with Plasmodium falci- of follow-up (7).
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