Safety Data Sheet Sodium Thiocyanate

SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

Version 2 Revision Date 26.11.2017 Print Date 24.10.2019 GB / EN

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

1.1 Product identifier Trade name : SODIUM THIOCYANATE

REACH Registration Number : 01-2119543700-47-0000 1.2 Relevant identified uses of the substance or mixture and uses advised against Use of the : Specific use(s): Use in synthesis and as Substance/Mixture intermediate. Use in spraying formulations. Building and construction work Laboratory activities

Specific use(s): Refer to attached exposure scenario Annex.

1.3 Details of the supplier of the safety data sheet Company : Carbosulf Chemische Werke GmbH Geestemünder Str.26 DE 50735 Köln Germany

Telephone : +4922174960 Telefax : +492217496190 E-mail address : [email protected] 1.4 Emergency telephone number Emergency telephone : 24 hours:+31 57 06 79211, CHEMTREC-USA:1-800-424- number 9300, CHEMTREC outside USA +1-703-527-3887, CANUTEC-CANADA:1-613-996-6666, 化学事故应急咨询电话：国家化学事故应急响应中心 +86 532 8388 9090

SECTION 2: HAZARDS IDENTIFICATION 2.1 Classification of the substance or mixture

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Classification (REGULATION (EC) No 1272/2008) Acute toxicity, 4, H302 Acute toxicity, 4, H332 Acute toxicity, 4, H312 Serious eye damage, 1, H318 Chronic aquatic toxicity, 3, H412

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements Labelling (REGULATION (EC) No 1272/2008) Pictogram :

Signal word : Danger

Hazard statements : H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled. H318 Causes serious eye damage. H412 Harmful to aquatic life with long lasting effects.

Precautionary statements : Prevention: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. Response: P302 + P352 + P312 IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P305 + P351 + P338 + P310 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.

Hazardous components which must be listed on the label: Thiocyanic acid, sodium salt 540-72-7 Additional Labelling: EUH032 Contact with acids liberates very toxic gas.

2.3 Other hazards

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No further data available.

PBT and vPvB assessment : This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

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SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS 3.1 Substances Pure substance/mixture : Substance

Hazardous substance

PBT CAS-No. Classification Concentration Chemical name vPvB EC-No. (REGULATION (EC) No 1272/2008) [%] OEL REACH No.

Thiocyanic acid, sodium salt 540-72-7 Acute Tox. 4; H302 >= 90 - <= 100 208-754-4 Acute Tox. 4; H332 01-2119543700-47 Acute Tox. 4; H312 Eye Dam. 1; H318 Aquatic Chronic 3; H412

For the full text of the H-Statements mentioned in this Section, see Section 16.

REACH - Candidate List of Substances of Very High Concern for Authorisation (Article 59). Status : Not applicable

SECTION 4: FIRST AID MEASURES 4.1 Description of first aid measures General advice : Immediate medical attention is required. Move out of dangerous area. Show this safety data sheet to the doctor in attendance.

If inhaled : Remove to fresh air. Keep patient warm and at rest. Rinse nose and mouth with water.

In case of skin contact : Take off contaminated clothing and shoes immediately. If skin irritation persists, call a physician.

In case of eye contact : Rinse with plenty of water. Get medical attention immediately. Continue to rinse during transport. Remove contact lenses. Protect unharmed eye. Keep eye wide open while rinsing.

If swallowed : Clean mouth with water and drink afterwards plenty of water. Never give anything by mouth to an unconscious person. Obtain medical attention.

4.2 Most important symptoms and effects, both acute and delayed Symptoms : The symptoms and effects are as expected from the hazards as shown in section 2. No specific product related symptoms are known. 4 / 107

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Risks : Harmful if swallowed, in contact with skin or if inhaled. Causes serious eye damage.

4.3 Indication of any immediate medical attention and special treatment needed Treatment : Treat symptomatically.

SECTION 5: FIREFIGHTING MEASURES 5.1 Extinguishing media Suitable extinguishing media : Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

5.2 Special hazards arising from the substance or mixture Specific hazards during : Do not allow run-off from fire fighting to enter drains or water firefighting / Specific hazards courses. arising from the chemical Heating may cause decomposition with release of toxic fumes.

Combustion products : Fire will produce smoke containing hazardous combustion products (see section 10).

5.3 Advice for firefighters Special protective equipment : In the event of fire, wear self-contained breathing apparatus. for firefighters Further information : Collect contaminated fire extinguishing water separately. This must not be discharged into drains. Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations.

SECTION 6: ACCIDENTAL RELEASE MEASURES 6.1 Personal precautions, protective equipment and emergency procedures Personal precautions : Use personal protective equipment. Wear respiratory protection. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation.

Emergency measures on : Evacuate personnel to safe areas. accidental release Only qualified personnel equipped with suitable protective equipment may intervene. Prevent unauthorised persons entering the zone.

6.2 Environmental precautions Environmental precautions : Try to prevent the material from entering drains or water courses. If the product contaminates rivers and lakes or drains inform respective authorities.

6.3 Methods and materials for containment and cleaning up Methods for cleaning up / : Pick up and arrange disposal without creating dust.

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Methods for containment Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal considerations see section 13. For personal protection see section 8.

SECTION 7: HANDLING AND STORAGE 7.1 Precautions for safe handling Advice on safe handling : For personal protection see section 8. Avoid formation of respirable particles. Do not breathe vapours/dust. Avoid contact with skin, eyes and clothing. Smoking, eating and drinking should be prohibited in the application area. Provide sufficient air exchange and/or exhaust in work rooms. Dispose of rinse water in accordance with local and national regulations. Keep away from heat and sources of ignition.

Advice on protection against : Provide appropriate exhaust ventilation at places where dust fire and explosion is formed.

7.2 Conditions for safe storage, including any incompatibilities Requirements for storage : Keep in a dry place. areas and containers Store at room temperature in the original container. Keep container tightly closed.

Advice on common storage : Do not store near acids.

Other data : No decomposition if stored and applied as directed.

7.3 Specific end use(s) Specific use(s) : Refer to attached exposure scenario Annex.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION 8.1 Control parameters Components with workplace control parameters

Contains no substances with occupational exposure limit values.

Occupational exposure limits of decomposition products

Decomposition CAS-No. Value Control Update Basis Form of products parameters exposure Carbon disulphide 75-15-0 TWA 5 ppm 2009-12-19 2009/161/EU 15 mg/m3 Further : skin: Identifies the possibility of significant uptake through the skin information Indicative TWA 5 ppm 2011-12-01 GB EH40 15 mg/m3 Further : Sk: Can be absorbed through skin. The assigned substances are those for information w hich there are concerns that dermal absorption w ill lead to systemic 6 / 107

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toxicity. 2: Where no specific short-term exposure limit is listed, a figure three times the long-term exposure should be used

Derived No Effect Level (DNEL) according to Regulation (EC) No. 1907/2006 Substance name End Use Exposure Potential health effects Value routes Thiocyanic acid, sodium salt Workers Inhalation Long-term systemic 3 mg/m3 effects Workers Skin contact Long-term systemic 1.7 mg/kg bw /day effects Consumers Inhalation Long-term systemic 1.1 mg/m3 effects Consumers Skin contact Long-term systemic 1.2 mg/kg bw /day effects Consumers Ingestion Long-term systemic 0.3 mg/kg bw /day effects

Predicted No Effect Concentration (PNEC) according to Regulation (EC) No. 1907/2006 Substance name Environmental Compartment Value Thiocyanic acid, sodium salt Fresh w ater 0.095 mg/l Marine w ater 0.0095 mg/l Intermittent w ater 0.0272 mg/l Sew age treatment plant 30 mg/l Fresh w ater sediment 0.543 mg/kg dry w eight Marine sediment 0.0543 mg/kg dry w eight Soil 6.336 mg/kg dry w eight Secondary Poisoning 1.667 mg/kg food

8.2 Exposure controls

Engineering controls Provide appropriate exhaust ventilation at places where dust is formed. Ensure that eyewash stations and safety showers are close to the workstation location. Personal protective equipment Respiratory protection : Half mask with a particle filter P2 (EN 143)

Hand protection : For prolonged or repeated contact use protective gloves.

Protective gloves complying with EN 374.

Eye protection : Tightly fitting safety goggles

Skin and body protection : Protective suit

Hygiene measures : Handle in accordance with good industrial hygiene and safety practice. When using do not eat or drink. When using do not smoke. Wash hands before breaks and at the end of workday.

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Environmental exposure controls General advice : Try to prevent the material from entering drains or water courses. If the product contaminates rivers and lakes or drains inform respective authorities.

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES 9.1 Information on basic physical and chemical properties Appearance Form : crystalline

Colour : white

Odour : odourless

Odour Threshold : No data available

Safety data pH : 5 - 9 at 5 % solution (as aqueous solution)

Melting point : 308 °C

Boiling point/boiling range : Not relevant.

Flash point : Not applicable

Evaporation rate : Not applicable

Flammability (solid, gas) : Not flammable

Flammability (liquids) : Not applicable

Lower explosion limit : Not applicable

Upper explosion limit : Not applicable

Vapour pressure : Not applicable

Relative vapour density : Not applicable

Relative density : 1.726

Bulk density : 700 - 800 kg/m3

Water solubility : 1,250 g/l at 20 °C

Solubility in other solvents : Soluble in:, Acetone, Methanol, Ethanol

Partition coefficient: n- : log Pow: -2.52 octanol/water estimated

Auto-ignition temperature : Not applicable 8 / 107

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Decomposition temperature : > 368 °C

Viscosity, dynamic : Not applicable

Viscosity, kinematic : Not applicable

Explosive properties : Not explosive

Oxidizing properties : Not relevant.

9.2 Other information This safety datasheet only contains information relating to safety and does not replace any product information or product specification.

SECTION 10: STABILITY AND REACTIVITY 10.1 Reactivity Stable under normal conditions. 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions Contact with acids liberates very toxic gas. Decomposition products may be flammable.

10.4 Conditions to avoid Conditions to avoid : None known.

10.5 Incompatible materials Materials to avoid : Incompatible with strong acids and oxidizing agents.

10.6 Hazardous decomposition products Hazardous decomposition : Carbon disulphide products Sodium oxide nitrogen oxides (NOx) Carbonyl sulfide Sulphur oxides

Thermal decomposition : > 368 °C

SECTION 11: TOXICOLOGICAL INFORMATION 11.1 Information on toxicological effects Product information: Acute toxicity : Harmful if swallowed, in contact with skin or if inhaled.

Skin corrosion/irritation : Not classified based on available information.

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Respiratory or skin : Respiratory sensitisation: Not classified based on available sensitisation information. Skin sensitisation: Not classified based on available information.

Germ cell mutagenicity : Not classified based on available information.

Carcinogenicity : Not classified based on available information.

Reproductive toxicity : Not classified based on available information.

STOT - single exposure : Not classified based on available information.

STOT - repeated exposure : Not classified based on available information.

Aspiration hazard : Not classified based on available information.

Further information : No further data available.

Test result Acute oral toxicity : Acute toxicity estimate: 546.46 mg/kg Method: Calculation method

Acute inhalation toxicity : Acute toxicity estimate : 1.52 mg/l Exposure time: 4 h Test atmosphere: dust/mist Method: Calculation method

Acute dermal toxicity : Acute toxicity estimate: 1,112 mg/kg Method: Calculation method

Toxicology data for the components: Thiocyanic acid, sodium salt Acute toxicity: Acute oral toxicity : LD50: 541 mg/kg Species: Coturnix japonica (Japanese quail) Method: OECD Test Guideline 401 Read-across from supporting substance (structural analogue or surrogate).

Acute inhalation toxicity : No data available

Acute dermal toxicity : LD50: > 2,000 mg/kg Species: Rat Method: OECD Test Guideline 402 Read-across (Analogy)

Skin corrosion/irritation : Result: No skin irritation

Serious eye damage/eye : Species: Rabbit irritation Result: Risk of serious damage to eyes.

Respiratory or skin : Species: Mouse sensitisation Classification: Does not cause skin sensitisation. Method: OECD Test Guideline 429

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Repeated dose toxicity : Species: Rat NOAEL: 21.3 mg/kg Application Route: Oral Read-across (Analogy)

Germ cell mutagenicity Genotoxicity in vitro : In vitro gene mutation study in mammalian cells mouse lymphoma cells Result: negative Method: OECD Test Guideline 476

Ames test Result: negative Method: OECD Test Guideline 471 Read-across from supporting substance (structural analogue or surrogate).

Chromosome aberration test in vitro Human lymphocytes Result: negative Method: OECD Test Guideline 473

Genotoxicity in vivo : Not classified due to data which are conclusive although insufficient for classification.

Carcinogenicity : study scientifically unjustified

Reproductive toxicity : Based on available data, the classification criteria are not met.

STOT - single exposure : Not classified due to data which are conclusive although insufficient for classification.

STOT - repeated exposure : Not classified due to data which are conclusive although insufficient for classification.

Aspiration hazard : Not classified due to data which are conclusive although insufficient for classification.

SECTION 12: ECOLOGICAL INFORMATION Product information: Ecotoxicology Assessment Additional ecological : An environmental hazard cannot be excluded in the event of information unprofessional handling or disposal. Toxic to aquatic life. Harmful to aquatic life with long lasting effects.

12.1 Toxicity Components: Test result Thiocyanic acid, sodium salt 11 / 107

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Toxicity to fish : LC50: 69 mg/l Exposure time: 96 h Species: Oncorhynchus mykiss (rainbow trout) Test Type: static test Method: OECD Test Guideline 203 Read-across from supporting substance (structural analogue or surrogate).

Toxicity to daphnia and other : EC50: 3.79 mg/l aquatic invertebrates Exposure time: 48 h Species: Daphnia magna (Water flea) Test Type: static test Method: OECD Test Guideline 202 Read-across from supporting substance (structural analogue or surrogate).

Toxicity to algae : EC10: 113.43 mg/l Exposure time: 72 h Species: Pseudokirchneriella subcapitata (green algae) Test Type: Growth inhibition Method: OECD Test Guideline 201 Read-across from supporting substance (structural analogue or surrogate).

ErC50: > 249.5 mg/l Exposure time: 72 h Species: Pseudokirchneriella subcapitata (green algae) Test Type: Growth inhibition Method: OECD Test Guideline 201 Read-across from supporting substance (structural analogue or surrogate).

Toxicity to bacteria : NOEC: 2.13 mg/l Exposure time: 28 d Test Type: static test Method: closed serum bottle Read-across from supporting substance (structural analogue or surrogate).

NOEC: 30 mg/l Exposure time: 12 h Test Type: static test Read-across from supporting substance (structural analogue or surrogate).

Toxicity to fish (Chronic : NOEC: 1.53 mg/l toxicity) Exposure time: 124 d Species: Pimephales promelas (fathead minnow) Read-across from supporting substance (structural analogue or surrogate).

Toxicity to daphnia and other : NOEC: 1.33 mg/l aquatic invertebrates Exposure time: 21 d (Chronic toxicity) reproduction rate Species: Daphnia magna (Water flea)

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Method: OECD Test Guideline 211 Read-across from supporting substance (structural analogue or surrogate).

12.2 Persistence and degradability Product information: Biodegradability : Result: Readily biodegradable.

Components: Thiocyanic acid, sodium salt Biodegradability : Result: Readily biodegradable. Method: Closed Bottle test

12.3 Bioaccumulative potential Product information: Bioaccumulation : Not expected considering the low log Pow value.

Components: Thiocyanic acid, sodium salt Bioaccumulation : Not expected considering the low log Pow value.

12.4 Mobility in soil Product information: Mobility : No data available

12.5 Results of PBT and vPvB assessment Product information: PBT and vPvB assessment : This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Components: Thiocyanic acid, sodium salt PBT and vPvB assessment : This substance is not considered to be a PBT (Persistent, Bioaccumulation, Toxic) This substance is not considered to be vPvB (very Persistent nor very Bioaccumulating) 12.6 Other adverse effects Product information: Biochemical Oxygen : No data available Demand (BOD) Components: Thiocyanic acid, sodium salt Biochemical Oxygen : No data available Demand (BOD)

SECTION 13: DISPOSAL CONSIDERATIONS 13.1 Waste treatment methods Product : The product should not be allowed to enter drains, water courses or the soil. 13 / 107

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Do not contaminate ponds, waterways or ditches with chemical or used container. Hazardous waste Dispose of contents/container in accordance with local regulation.

Contaminated packaging : Empty remaining contents. Dispose of as unused product.

SECTION 14: TRANSPORT INFORMATION 14.1 UN number Not regulated as a dangerous good 14.2 Proper shipping name Not regulated as a dangerous good 14.3 Transport hazard class Not regulated as a dangerous good 14.4 Packing group Not regulated as a dangerous good 14.5 Environmental hazards Not regulated as a dangerous good 14.6 Special precautions for user Remarks : Not classified as dangerous in the meaning of transport regulations.

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code Not applicable for product as supplied.

SECTION 15: REGULATORY INFORMATION 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. Not applicable

Notification status DSL : YES. All components of this product are on the Canadian DSL AICS : YES. On the inventory, or in compliance with the inventory NZIoC : YES. On the inventory, or in compliance with the inventory ENCS : YES. On the inventory, or in compliance with the inventory ISHL : YES. On the inventory, or in compliance with the inventory KECI : YES. On the inventory, or in compliance with the inventory PICCS : YES. On the inventory, or in compliance with the inventory IECSC : YES. On the inventory, or in compliance with the inventory TCSI : YES. On the inventory, or in compliance with the inventory TSCA : YES. All chemical substances in this product are either listed on the TSCA Inventory or in compliance with a TSCA Inventory exemption.

For explanation of abbreviation see section 16. 14 / 107

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15.2 Chemical safety assessment Thiocyanic acid, sodium salt : A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: OTHER INFORMATION

Full text of H-Statements referred to under sections 2 and 3. H302 : Harmful if swallowed. H312 : Harmful in contact with skin. H318 : Causes serious eye damage. H332 : Harmful if inhaled. H412 : Harmful to aquatic life with long lasting effects.

Full text of other abbreviations 2009/161/EU : Europe. COMMISSION DIRECTIVE 2009/161/EU establishing a third list of indicative occupational exposure limit values in implementation of Council Directive 98/24/EC and amending Commission Directive 2000/39/EC GB EH40 : UK. EH40 WEL - Workplace Exposure Limits 2009/161/EU / TWA : Limit Value - eight hours GB EH40 / TWA : Long-term exposure limit (8-hour TWA reference period)

ADN - European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways; ADR - European Agreement concerning the International Carriage of Dangerous Goods by Road; AICS - Australian Inventory of Chemical Substances; ASTM - American Society for the Testing of Materials; bw - Body weight; CLP - Classification Labelling Packaging Regulation; Regulation (EC) No 1272/2008; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN - Standard of the German Institute for Standardisation; DSL - Domestic Substances List (Canada); ECHA - European Chemicals Agency; EC-Number - European Community number; ECx - Concentration associated with x% response; ELx - Loading rate associated with x% response; EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx - Concentration associated with x% growth rate response; GHS - Globally Harmonized System; GLP - Good Laboratory Practice; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; IBC - International Code for the Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO - International Organisation for Standardization; KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose); MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. - Not Otherwise Specified; NO(A)EC - No Observed (Adverse) Effect Concentration; NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No Observable Effect Loading Rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organization for Economic Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; RID - Regulations concerning the International Carriage of Dangerous Goods by Rail; SADT - Self- Accelerating Decomposition Temperature; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TRGS - Technical Rule for Hazardous Substances; TSCA - Toxic 15 / 107

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Substances Control Act (United States); UN - United Nations; vPvB - Very Persistent and Very Bioaccumulative

Further information The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.

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Annex :

1. Formulation & (re)packing of substances and mixtures, Dustiness: Low

2. Formulation & (re)packing of substances and mixtures, Dustiness: Medium

3. Formulation & (re)packing of substances and mixtures, Dustiness: High

4. Industrial use, Use as an intermediate

5. Industrial use, Spraying

6. Industrial use, Processing aid, Dustiness: Low

7. Industrial use, Processing aid, Dustiness: Medium

8. Industrial use, Processing aid, Dustiness: High

9. Professional use, Spraying

10. Professional use, Processing aid, Dustiness: Low

11. Professional use, Processing aid, Dustiness: Medium

12. Professional use, Processing aid, Dustiness: High

13. Industrial use, Building and construction work

14. Professional use, Building and construction work

15. Professional use, Used as laboratory reagent

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1. Short title of Exposure Scenario: Formulation & (re)packing of substances and mixtures, Dustiness: Low

Main User Groups : SU 3: Industrial uses: Uses of substances as such or in preparations at industrial sites Environmental Release : ERC2: Formulation of preparations Categories Process categories : PROC1: Use in closed process, no likelihood of exposure PROC2: Use in closed, continuous process with occasional controlled exposure PROC3: Use in closed batch process (synthesis or formulation) PROC4: Use in batch and other process (synthesis) where opportunity for exposure arises PROC5: Mixing or blending in batch processes for formulation of preparations and articles (multistage and/ or significant contact) PROC8a: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at non- dedicated facilities PROC8b: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at dedicated facilities PROC9: Transfer of substance or preparation into small containers (dedicated filling line, including weighing) PROC10: Roller application or brushing PROC14: Production of preparations or articles by tabletting, compression, extrusion, pelletisation PROC15: Use as laboratory reagent PROC19: Hand-mixing with intimate contact and only PPE available

2.1 Contributing scenario controlling environmental exposure for: ERC2: Formulation of preparations

Amount used Regional use tonnage : 15260 ton(s)/year (tonnes/year): Fraction of EU tonnage used in : 100 % region: Fraction of Regional tonnage : 0.2 % used locally: Maximum daily site tonnage : 102 kg/day (kg/day):

Environment factors not influenced by risk management Flow rate : 18,000 m3/day Dilution Factor (River) : 10 Dilution Factor (Coastal Areas) : 100

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Other given operational conditions affecting environmental exposure Number of emission days per : 300 year Emission or Release Factor: Air : 2.5 % Emission or Release Factor: : 2 % Water Emission or Release Factor: Soil : 0 %

Conditions and measures related to municipal sewage treatment plant Type of Sewage Treatment Plant : Municipal sewage treatment plant Flow rate of sewage treatment : 2,000 m3/day plant effluent Percentage removed from waste : 0 % water

2.2 Contributing scenario controlling worker exposure for: All PROCs: Applicable to all above mentioned process categories.

Activity : Industrial use Product characteristics Concentration of the Substance : Covers the percentage of the substance in the product up in Mixture/Article to 100 % (unless stated differently). Physical Form (at time of use) : Solid, low dustiness Vapour pressure : < 0.01 Pa

Frequency and duration of use Application duration : <= 8 h Frequency of use : <= 365 days/year

Other operational conditions affecting workers exposure Outdoor / Indoor : Indoor

Organisational measures to prevent /limit releases, dispersion and exposure Assumes a good basic standard of occupational hygiene is implemented, Ensure operatives are trained to minimise exposures., Clean equipment and the work area every day., Clear spills immediately.

Conditions and measures related to personal protection, hygiene and health evaluation Use suitable eye protection.

2.3 Contributing scenario controlling worker exposure for: PROC1: Use in closed process, no likelihood of exposure

Activity : General exposures (closed systems), Continuous process

Technical conditions and measures No specific measures identified., Handle substance within a closed system., Clear transfer lines prior to de-coupling.

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2.4 Contributing scenario controlling worker exposure for: PROC2: Use in closed, continuous process with occasional controlled exposure

Activity : General exposures (closed systems), Continuous process, Automated process with (semi) closed systems

Technical conditions and measures No specific measures identified., Handle substance within a closed system., Clear transfer lines prior to de-coupling.

2.5 Contributing scenario controlling worker exposure for: PROC3: Use in closed batch process (synthesis or formulation)

Activity : General exposures, Use in contained batch processes

Technical conditions and measures No specific measures identified., Handle substance within a closed system., Drain down and flush system prior to equipment opening or maintenance.

2.6 Contributing scenario controlling worker exposure for: PROC4: Use in batch and other process (synthesis) where opportunity for exposure arises

Activity : General exposures, Open systems, Batch process

Conditions and measures related to personal protection, hygiene and health evaluation When concentration is:, >5%, Wear chemically resistant gloves (tested to EN374) in combination with ‘basic’ employee training. (Effectiveness (of a measure): 90 %)

2.7 Contributing scenario controlling worker exposure for: PROC5: Mixing or blending in batch processes for formulation of preparations and articles (multistage and/ or significant contact)

Activity : General exposures, Mixing operations (open systems), Batch process

2.8 Contributing scenario controlling worker exposure for: PROC8a: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at non-dedicated facilities

Activity : General exposures, Non-dedicated facility, Material transfers 20 / 107

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2.9 Contributing scenario controlling worker exposure for: PROC8b: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at dedicated facilities

Activity : General exposures, Dedicated facility, Material transfers

2.10 Contributing scenario controlling worker exposure for: PROC9: Transfer of substance or preparation into small containers (dedicated filling line, including weighing)

Activity : General exposures, Dedicated facility, Drum and small package filling, Material transfers

2.11 Contributing scenario controlling worker exposure for: PROC10: Roller application or brushing

Activity : General exposures (open systems), Rolling, Brushing, Equipment cleaning and maintenance

Organisational measures to prevent /limit releases, dispersion and exposure Limit the substance content in the product to 25 %.

2.12 Contributing scenario controlling worker exposure for: PROC14: Production of preparations or articles by tabletting, compression, extrusion, pelletisation

Activity : General exposures (open systems), Production or preparation or articles by tabletting, compression, extrusion or pelletisation

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Conditions and measures related to personal protection, hygiene and health evaluation When concentration is:, >5%, Wear suitable gloves tested to EN374. (Effectiveness (of a measure): 80 %)

2.13 Contributing scenario controlling worker exposure for: PROC15: Use as laboratory reagent

Activity : General exposures, Laboratory activities, Small scale, Manual

Technical conditions and measures No specific measures identified.

2.14 Contributing scenario controlling worker exposure for: PROC19: Hand-mixing with intimate contact and only PPE available

Activity : General exposures, Mixing operations (open systems), Manual

Organisational measures to prevent /limit releases, dispersion and exposure Limit the substance content in the product to 5 %.

3. Exposure estimation and reference to its source

Environment

Contributing Exposure Specific Compartme Value Level of RCR Scenario Assessment conditions nt Exposure Method ERC2 EUSES Fresh water 0.012 mg/L 0.118 EUSES Marine 0.001 mg/L 0.112 water EUSES Sewage 0.04 mg/L 0.001 treatment plant EUSES Soil 0.005 mg/kg 0.0008 dry weight

Workers

Contributing Exposure Specific conditions Value Level of RCR Scenario Assessment Exposure

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Method PROC1 ECETOC TRA Long term 0.01 mg/m³ 0.003 inhalation Long term 0.34 mg/kg 0.167 dermal bw/day PROC2 ECETOC TRA Long term 0.01 mg/m3 0.01 inhalation Long term 1.37 mg/kg 0.672 dermal bw/day PROC3 ECETOC TRA Long term 0.1 mg/m³ 0.028 inhalation Long term 0.343 mg/kg 0.168 dermal bw/day PROC4 ECETOC TRA Long term 0.5 mg/m³ 0.139 inhalation Long term 0.69 mg/kg 0.338 dermal bw/day PROC5 ECETOC TRA Long term 0.5 mg/m³ 0.139 inhalation Long term 0.69 mg/kg 0.338 dermal bw/day PROC8a ECETOC TRA Long term 0.5 mg/m³ 0.139 inhalation Long term 0.69 mg/kg 0.338 dermal bw/day PROC8b ECETOC TRA Long term 0.1 mg/m³ 0.028 inhalation Long term 0.69 mg/kg 0.338 dermal bw/day PROC9 ECETOC TRA Long term 0.1 mg/m³ 0.028 inhalation Long term 0.69 mg/kg 0.338 dermal bw/day PROC10 ECETOC TRA Long term 0.3 mg/m³ 0.083 inhalation Long term 0.82 mg/kg 0.402 dermal bw/day PROC14 ECETOC TRA Long term 0.1 mg/m³ 0.028 inhalation Long term 0.69 mg/kg 0.338 dermal bw/day PROC15 ECETOC TRA Long term 0.1 mg/m³ 0.028 inhalation Long term 0.34 mg/kg 0.167 dermal bw/day PROC19 ECETOC TRA Long term 0.1 mg/m³ 0.028 inhalation Long term 1.4 mg/kg 0.686 dermal bw/day

ERC2: Formulation of preparations PROC1: Use in closed process, no likelihood of exposure PROC10: Roller application or brushing

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PROC14: Production of preparations or articles by tabletting, compression, extrusion, pelletisation PROC15: Use as laboratory reagent PROC19: Hand-mixing with intimate contact and only PPE available PROC2: Use in closed, continuous process with occasional controlled exposure PROC3: Use in closed batch process (synthesis or formulation) PROC4: Use in batch and other process (synthesis) where opportunity for exposure arises PROC5: Mixing or blending in batch processes for formulation of preparations and articles (multistage and/ or significant contact) PROC8a: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at non-dedicated facilities PROC8b: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at dedicated facilities PROC9: Transfer of substance or preparation into small containers (dedicated filling line, including weighing)

4. Guidance to Downstream User to evaluate whether he works inside the boundaries set by the Exposure Scenario

For further information, please also consult our Internet site: Downstream Users http://guidance.echa.europa.eu/downstream_users_en.htm

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1. Short title of Exposure Scenario: Formulation & (re)packing of substances and mixtures, Dustiness: Medium

Main User Groups : SU 3: Industrial uses: Uses of substances as such or in preparations at industrial sites Environmental Release : ERC2: Formulation of preparations Categories Process categories : PROC1: Use in closed process, no likelihood of exposure PROC2: Use in closed, continuous process with occasional controlled exposure PROC3: Use in closed batch process (synthesis or formulation) PROC4: Use in batch and other process (synthesis) where opportunity for exposure arises PROC5: Mixing or blending in batch processes for formulation of preparations and articles (multistage and/ or significant contact) PROC8a: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at non- dedicated facilities PROC8b: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at dedicated facilities PROC9: Transfer of substance or preparation into small containers (dedicated filling line, including weighing) PROC14: Production of preparations or articles by tabletting, compression, extrusion, pelletisation PROC15: Use as laboratory reagent PROC19: Hand-mixing with intimate contact and only PPE available

2.1 Contributing scenario controlling environmental exposure for: ERC2: Formulation of preparations

Environment factors not influenced by risk management Flow rate : 18,000 m3/day Dilution Factor (River) : 10 Dilution Factor (Coastal Areas) : 100

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Number of emission days per : 300 year Emission or Release Factor: Air : 2.5 % Emission or Release Factor: : 2 % Water Emission or Release Factor: Soil : 0 %

2.2 Contributing scenario controlling worker exposure for: All PROCs: Applicable to all above mentioned process categories.

Product characteristics Concentration of the Substance : Covers the percentage of the substance in the product up in Mixture/Article to 100 % (unless stated differently). Physical Form (at time of use) : Solid, medium dustiness Vapour pressure : < 0.001 Pa

Frequency and duration of use Application duration : <= 8 h Frequency of use : <= 365 days/year

Other operational conditions affecting workers exposure Outdoor / Indoor : Indoor

Conditions and measures related to personal protection, hygiene and health evaluation Use suitable eye protection.

Additional good practice advice beyond the REACH Chemical Safety Assessment Additional good practice advice : Respirators: - Wear a disposable mask only once - Clean non-disposable masks after each use and store in a clean box in a clean area - Wear respirators ≤ 2 hrs/day,Avoid carrying out operation for more than 4 hours.

2.3 Contributing scenario controlling worker exposure for: PROC1: Use in closed process, no likelihood of exposure

Activity : General exposures (closed systems), Continuous process

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No specific measures identified., Handle substance within a closed system., Clear transfer lines prior to de-coupling.

2.4 Contributing scenario controlling worker exposure for: PROC2: Use in closed, continuous process with occasional controlled exposure

Activity : General exposures (closed systems), Continuous process, Automated process with (semi) closed systems

Conditions and measures related to personal protection, hygiene and health evaluation Wear suitable gloves tested to EN374. (Effectiveness (of a measure): 80 %)

2.5 Contributing scenario controlling worker exposure for: PROC3: Use in closed batch process (synthesis or formulation)

Activity : General exposures, Use in contained batch processes

Technical conditions and measures No specific measures identified., Handle substance within a closed system., Drain down and flush system prior to equipment opening or maintenance.

2.6 Contributing scenario controlling worker exposure for: PROC4: Use in batch and other process (synthesis) where opportunity for exposure arises

Activity : General exposures, Batch process, Open systems

Technical conditions and measures When concentration is:, >5%, Ensure material transfers are under containment or extract ventilation., Provide extract ventilation to material transfer points and other openings. (Effectiveness (of a measure): 90 %)

2.7 Contributing scenario controlling worker exposure for: PROC5: Mixing or blending in batch processes for formulation of preparations and articles (multistage and/ or significant contact)

Activity : General exposures, Mixing operations (open systems), Batch process

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(Effectiveness (of a measure): 90 %)

2.8 Contributing scenario controlling worker exposure for: PROC8a: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at non-dedicated facilities

Activity : General exposures, Material transfers, Non-dedicated facility

2.9 Contributing scenario controlling worker exposure for: PROC8b: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at dedicated facilities

Activity : General exposures, Material transfers, Dedicated facility

2.10 Contributing scenario controlling worker exposure for: PROC9: Transfer of substance or preparation into small containers (dedicated filling line, including weighing)

Activity : Drum and small package filling, General exposures, Material transfers, Dedicated facility

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2.11 Contributing scenario controlling worker exposure for: PROC14: Production of preparations or articles by tabletting, compression, extrusion, pelletisation

Activity : General exposures (open systems), Production or preparation or articles by tabletting, compression, extrusion or pelletisation

Conditions and measures related to personal protection, hygiene and health evaluation When concentration is:, >5%, Wear suitable gloves tested to EN374. (Effectiveness (of a measure): 80 %)

2.13 Contributing scenario controlling worker exposure for: PROC15: Use as laboratory reagent

Activity : General exposures, Laboratory activities, Small scale, Manual

Technical conditions and measures No specific measures identified.

2.14 Contributing scenario controlling worker exposure for: PROC19: Hand-mixing with intimate contact and only PPE available

Activity : General exposures, Mixing operations (open systems), Manual

Organisational measures to prevent /limit releases, dispersion and exposure Avoid carrying out operation for more than 1 hour., Limit the substance content in the product to 5 %.

Conditions and measures related to personal protection, hygiene and health evaluation Wear chemically resistant gloves (tested to EN374) in combination with specific activity training. (Effectiveness (of a measure): 95 %) Wear a respirator conforming to EN140 with Type A/P2 filter or better. (Effectiveness (of a measure): 90 %)

3. Exposure estimation and reference to its source

Environment

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Workers

Contributing Exposure Specific conditions Value Level of RCR Scenario Assessment Exposure Method PROC1 ECETOC TRA Long term 0.01 mg/m³ 0.003 inhalation Long term 0.34 mg/kg 0.167 dermal bw/day PROC2 ECETOC TRA Long term 0.5 mg/m3 0.132 inhalation Long term 0.27 mg/kg 0.271 dermal bw/day PROC3 ECETOC TRA Long term 1 mg/m³ 0.278 inhalation Long term 0.34 mg/kg 0.167 dermal bw/day PROC4 ECETOC TRA Long term 0.5 mg/m³ 0.338 inhalation Long term 0.69 mg/kg 0.477 dermal bw/day PROC5 ECETOC TRA Long term 0.5 mg/m³ 0.139 inhalation Long term 1.37 mg/kg 0.672 dermal bw/day PROC8a ECETOC TRA Long term 0.5 mg/m³ 0.139 inhalation Long term 1.371 mg/kg 0.672 dermal bw/day PROC8b ECETOC TRA Long term 1 mg/m³ 0.278 inhalation Long term 0.69 mg/kg 0.338 dermal bw/day PROC9 ECETOC TRA Long term 0.5 mg/m³ 0.139 inhalation Long term 0.69 mg/kg 0.338 dermal bw/day PROC14 ECETOC TRA Long term 1 mg/m³ 0.278 inhalation Long term 0.69 mg/kg 0.338 dermal bw/day PROC15 ECETOC TRA Long term 0.5 mg/m³ 0.139 30 / 107

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inhalation Long term 0.34 mg/kg 0.167 dermal bw/day PROC19 ECETOC TRA Long term 0.2 mg/m³ 0.056 inhalation Long term 1.4 mg/kg 0.686 dermal bw/day

ERC2: Formulation of preparations PROC1: Use in closed process, no likelihood of exposure PROC14: Production of preparations or articles by tabletting, compression, extrusion, pelletisation PROC15: Use as laboratory reagent PROC19: Hand-mixing with intimate contact and only PPE available PROC2: Use in closed, continuous process with occasional controlled exposure PROC3: Use in closed batch process (synthesis or formulation) PROC4: Use in batch and other process (synthesis) where opportunity for exposure arises PROC5: Mixing or blending in batch processes for formulation of preparations and articles (multistage and/ or significant contact) PROC8a: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at non-dedicated facilities PROC8b: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at dedicated facilities PROC9: Transfer of substance or preparation into small containers (dedicated filling line, including weighing)

4. Guidance to Downstream User to evaluate whether he works inside the boundaries set by the Exposure Scenario

For further information, please also consult our Internet site: Downstream Users http://guidance.echa.europa.eu/downstream_users_en.htm

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1. Short title of Exposure Scenario: Formulation & (re)packing of substances and mixtures, Dustiness: High

Main User Groups : SU 3: Industrial uses: Uses of substances as such or in preparations at industrial sites Environmental Release : ERC2: Formulation of preparations Categories Process categories : PROC1: Use in closed process, no likelihood of exposure PROC2: Use in closed, continuous process with occasional controlled exposure PROC3: Use in closed batch process (synthesis or formulation) PROC4: Use in batch and other process (synthesis) where opportunity for exposure arises PROC5: Mixing or blending in batch processes for formulation of preparations and articles (multistage and/ or significant contact) PROC8a: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at non- dedicated facilities PROC8b: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at dedicated facilities PROC9: Transfer of substance or preparation into small containers (dedicated filling line, including weighing) PROC14: Production of preparations or articles by tabletting, compression, extrusion, pelletisation PROC15: Use as laboratory reagent PROC19: Hand-mixing with intimate contact and only PPE available

2.1 Contributing scenario controlling environmental exposure for: ERC2: Formulation of preparations

Environment factors not influenced by risk management Flow rate : 18,000 m3/day Dilution Factor (River) : 10 Dilution Factor (Coastal Areas) : 100

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Number of emission days per : 300 year Emission or Release Factor: Air : 2.5 % Emission or Release Factor: : 2 % Water Emission or Release Factor: Soil : 0 %

2.2 Contributing scenario controlling worker exposure for: All PROCs: Applicable to all above mentioned process categories.

Product characteristics Concentration of the Substance : Covers the percentage of the substance in the product up in Mixture/Article to 25 %. Physical Form (at time of use) : Solid, high dustiness Vapour pressure : < 0.001 Pa

Frequency and duration of use Application duration : <= 8 h Frequency of use : <= 365 days/year

Other operational conditions affecting workers exposure Outdoor / Indoor : Indoor

Conditions and measures related to personal protection, hygiene and health evaluation Use suitable eye protection.

2.3 Contributing scenario controlling worker exposure for: PROC1: Use in closed process, no likelihood of exposure

Activity : General exposures (closed systems), Continuous process

Technical conditions and measures No specific measures identified., Handle substance within a closed system., Clear transfer lines prior to de-coupling.

2.4 Contributing scenario controlling worker exposure for: PROC2: Use in closed, continuous process with occasional controlled exposure

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Activity : General exposures (closed systems), Continuous process, Automated process with (semi) closed systems

Conditions and measures related to personal protection, hygiene and health evaluation Wear suitable gloves tested to EN374. (Effectiveness (of a measure): 80 %)

2.5 Contributing scenario controlling worker exposure for: PROC3: Use in closed batch process (synthesis or formulation)

Activity : General exposures, Use in contained batch processes

Technical conditions and measures No specific measures identified., Handle substance within a closed system., Drain down and flush system prior to equipment opening or maintenance.

2.6 Contributing scenario controlling worker exposure for: PROC4: Use in batch and other process (synthesis) where opportunity for exposure arises

Activity : General exposures, Batch process, Open systems

Technical conditions and measures Provide extraction ventilation at points where emissions occur., Ensure material transfers are under containment or extract ventilation. (Effectiveness (of a measure): 90 %)

2.7 Contributing scenario controlling worker exposure for: PROC5: Mixing or blending in batch processes for formulation of preparations and articles (multistage and/ or significant contact)

Activity : General exposures, Mixing operations (open systems), Batch process

Technical conditions and measures Ensure material transfers are under containment or extract ventilation., Provide extract ventilation to material transfer points and other openings. (Effectiveness (of a measure): 90 %)

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2.8 Contributing scenario controlling worker exposure for: PROC8a: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at non-dedicated facilities

Activity : General exposures, Non-dedicated facility, Material transfers

Organisational measures to prevent /limit releases, dispersion and exposure Avoid carrying out operation for more than 4 hours.

2.9 Contributing scenario controlling worker exposure for: PROC8b: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at dedicated facilities

Activity : General exposures, Material transfers, Dedicated facility

2.10 Contributing scenario controlling worker exposure for: PROC9: Transfer of substance or preparation into small containers (dedicated filling line, including weighing)

Activity : General exposures, Dedicated facility, Drum and small package filling, Material transfers

Conditions and measures related to personal protection, hygiene and health evaluation Wear a respirator conforming to EN140 with Type A/P2 filter or better. (Effectiveness (of a measure): 90 %)

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2.11 Contributing scenario controlling worker exposure for: PROC14: Production of preparations or articles by tabletting, compression, extrusion, pelletisation

Activity : General exposures (open systems), Production or preparation or articles by tabletting, compression, extrusion or pelletisation

Technical conditions and measures Ensure material transfers are under containment or extract ventilation., Use dedicated equipment. (Effectiveness (of a measure): 90 %)

Conditions and measures related to personal protection, hygiene and health evaluation Wear suitable gloves tested to EN374. (Effectiveness (of a measure): 80 %)

2.13 Contributing scenario controlling worker exposure for: PROC15: Use as laboratory reagent

Activity : General exposures, Laboratory activities, Small scale, Manual

Technical conditions and measures No specific measures identified.

2.14 Contributing scenario controlling worker exposure for: PROC19: Hand-mixing with intimate contact and only PPE available

Activity : General exposures, Mixing operations (open systems), Manual

Organisational measures to prevent /limit releases, dispersion and exposure Limit the substance content in the product to 5 %., Avoid carrying out operation for more than 1 hour.

3. Exposure estimation and reference to its source

Environment

Contributing Exposure Specific Compartme Value Level of RCR Scenario Assessment conditions nt Exposure Method ERC2 EUSES Fresh water 0.012 mg/L 0.118 36 / 107

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EUSES Marine 0.001 mg/L 0.112 water EUSES Sewage 0.04 mg/L 0.001 treatment plant EUSES Soil 0.005 mg/kg 0.0008 dry weight

Workers

Contributing Exposure Specific conditions Value Level of RCR Scenario Assessment Exposure Method PROC1 ECETOC TRA Long term 0.01 mg/m³ 0.003 inhalation Long term 0.34 mg/kg 0.167 dermal bw/day PROC2 ECETOC TRA Long term 1 mg/m3 0.278 inhalation Long term 0.27 mg/kg 0.132 dermal bw/day PROC3 ECETOC TRA Long term 1 mg/m³ 0.278 inhalation Long term 0.34 mg/kg 0.167 dermal bw/day PROC4 ECETOC TRA Long term 1.5 mg/m³ 0.417 inhalation Long term 0.41 mg/kg 0.201 dermal bw/day PROC5 ECETOC TRA Long term 1.5 mg/m³ 0.417 inhalation Long term 0.41 mg/kg 0.201 dermal bw/day PROC8a ECETOC TRA Long term 1.8 mg/m³ 0.5 inhalation Long term 0.41 mg/kg 0.201 dermal bw/day PROC8b ECETOC TRA Long term 1.5 mg/m³ 0.417 inhalation Long term 0.41 mg/kg 0.201 dermal bw/day PROC9 ECETOC TRA Long term 1.2 mg/m³ 0.333 inhalation Long term 0.41 mg/kg 0.201 dermal bw/day PROC14 ECETOC TRA Long term 0.6 mg/m³ 0.167 inhalation Long term 0.41 mg/kg 0.201 dermal bw/day PROC15 ECETOC TRA Long term 1 mg/m³ 0.278 inhalation Long term 0.34 mg/kg 0.167 dermal bw/day PROC19 ECETOC TRA Long term 0.3 mg/m³ 0.083

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inhalation Long term 1.41 mg/kg 0.691 dermal bw/day

4. Guidance to Downstream User to evaluate whether he works inside the boundaries set by the Exposure Scenario

For further information, please also consult our Internet site: Downstream Users http://guidance.echa.europa.eu/downstream_users_en.htm

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1. Short title of Exposure Scenario: Industrial use, Use as an intermediate

Main User Groups : SU 3: Industrial uses: Uses of substances as such or in preparations at industrial sites Environmental Release : ERC6a: Industrial use resulting in manufacture of another Categories substance (use of intermediates) Process categories : PROC1: Use in closed process, no likelihood of exposure PROC2: Use in closed, continuous process with occasional controlled exposure PROC3: Use in closed batch process (synthesis or formulation) PROC4: Use in batch and other process (synthesis) where opportunity for exposure arises PROC8a: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at non- dedicated facilities PROC8b: Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large containers at dedicated facilities PROC10: Roller application or brushing PROC15: Use as laboratory reagent

2.1 Contributing scenario controlling environmental exposure for: ERC6a: Industrial use resulting in manufacture of another substance (use of intermediates)

Activity : Industrial use, Spraying

Environment factors not influenced by risk management Flow rate : 18,000 m3/day Dilution Factor (River) : 10 Dilution Factor (Coastal Areas) : 100

Other given operational conditions affecting environmental exposure Number of emission days per : 300 year Emission or Release Factor: Air : 5 % Emission or Release Factor: : 2 % Water Emission or Release Factor: Soil : 0 %

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