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General Catalog of Kanto Reagents, Chemicals & Biologicals + Oct. 2021 Saccharomyces cerevisiae EZ-Accu ShotTM store at 2℃-8℃ 49944-78 MB（0699A） ATCC9763 5test JPY46,000 Saccharomyces cerevisiae KWIK-STIKTM store at 2℃-8℃ 49843-14 MB（0534P） ATCC4098 2pack JPY13,500 49843-15 MB（0900P） ATCC9080 2pack JPY13,500 49823-87 MB（0699P） ATCC9763 2pack JPY13,500 49820-65 MB（01066P） ATCC18824 2pack JPY14,500 49825-87 MB（0736P） NCYC79 2pack JPY14,500 Saccharomyces cerevisiae KWIK-STIKTM Plus store at 2℃-8℃ 49842-47 MB（0699X） ATCC9763 5pack JPY45,000 Saccharomyces kudriavzevii KWIK-STIKTM store at 2℃-8℃ 49823-86 MB（0698P） ATCC2601 2pack JPY13,500 Saccharomyces kudriavzevii KWIK-STIKTM Plus store at 2℃-8℃ 49840-76 MB（0698X） ATCC2601 5pack JPY45,000 Salmonella bongori KWIK-STIKTM store at 2℃-8℃ 49843-52 MB（0595P） ATCC43975 2pack JPY16,500 General Catalog of Kanto Reagents, Chemicals & Biologicals + Oct. 2021 Salmonella enterica subsp.arizonae EZ-Accu ShotTM store at 2℃-8℃ 49946-13 MB（0901A） ATCC13314 5test JPY46,000 Salmonella enterica subsp.arizonae KWIK-STIKTM store at 2℃-8℃ 49823-91 MB（0901P） ATCC13314 2pack JPY13,500 Salmonella enterica subsp.diarizonae KWIK-STIKTM store at 2℃-8℃ 49820-33 MB（01054P） ATCC12325 2pack JPY14,500 49844-90 MB（01045P） ATCC29934 2pack JPY14,500 Salmonella enterica subsp.enterica serotype Abony EZ-CFUTM store at 2℃-8℃ 49840-79 MB（0890C） NCTC6017 10test JPY87,000 Salmonella enterica subsp.enterica serotype Abony EZ-CFUTM One Step store at 2℃-8℃ 49842-70 MB（0890Z） NCTC6017 10test JPY86,000 Salmonella enterica subsp.enterica serotype Abony KWIK-STIKTM store at 2℃-8℃ 49825-88 MB（0890P） NCTC6017 2pack JPY11,500 General Catalog of Kanto Reagents, Chemicals & Biologicals + Oct. 2021 Salmonella enterica subsp.enterica serotype Abony KWIK-STIKTM Plus store at 2℃-8℃ 49840-77 MB（0890X） NCTC6017 5pack JPY45,000 Salmonella enterica subsp.enterica serotype Nottingham KWIK-STIKTM store at 2℃-8℃ 49945-57 MB（01257P） NCTC7832 2pack JPY13,500 Salmonella enterica subsp.enterica serovar Abaetetuba KWIK-STIKTM store at 2℃-8℃ 49823-89 MB（0817P） ATCC35640 2pack JPY13,500 49945-86 MB（0826P） SillikerSLR156 2pack JPY11,500 Salmonella enterica subsp. enterica serovar Abony EZ-Accu ShotTM store at 2℃-8℃ 49944-79 MB（0890A） NCTC6017 5test JPY46,000 Salmonella enterica subsp.enterica serovar Anatum KWIK-STIKTM store at 2℃-8℃ Group E 49823-90 MB（0346P） ATCC9270 2pack JPY11,500 Salmonella enterica subsp.enterica serovar Infantis KWIK-STIKTM store at 2℃-8℃ 49841-88 MB（0501P） ATCC51741 2pack JPY14,500 General Catalog of Kanto Reagents, Chemicals & Biologicals + Oct. 2021 Salmonella enterica subsp.enterica serovar Newport KWIK-STIKTM store at 2℃-8℃ 49944-51 MB（01095P） ATCC6962 2pack JPY13,500 Salmonella enterica subsp.enterica serovar Poona KWIK-STIKTM store at 2℃-8℃ 49841-90 MB（0851P） NCTC4840 2pack JPY11,500 Salmonella enterica subsp.salamae serotype Tranoroa KWIK-STIKTM store at 2℃-8℃ 49944-52 MB（01087P） NCTC10252 2pack JPY13,500 Serratia liquefaciens KWIK-STIKTM store at 2℃-8℃ 49824-03 MB（0838P） ATCC27592 2pack JPY11,500 Serratia marcescens KWIK-STIKTM store at 2℃-8℃ 49824-04 MB（0354P） ATCC8100 2pack JPY11,500 49825-89 MB（0247P） ATCC13880 2pack JPY13,500 49841-92 MB（0506P） ATCC14041 2pack JPY14,500 49824-05 MB（0806P） ATCC14756 2pack JPY13,500 49825-91 MB（0262P） ATCC43862 2pack JPY11,500 Serratia marcescens KWIK-STIKTM Plus store at 2℃-8℃ 49944-89 MB（0806X） ATCC14756 5pack JPY45,000 General Catalog of Kanto Reagents, Chemicals & Biologicals + Oct. 2021 Shewanella haliotis KWIK-STIKTM store at 2℃-8℃ 49824-08 MB（0638P） ATCC49138 2pack JPY11,500 Sphingobacterium multivorum KWIK-STIKTM store at 2℃-8℃ 49824-16 MB（0948P） ATCC35656 2pack JPY11,500 Sphingomonas paucimobilis KWIK-STIKTM store at 2℃-8℃ 49842-01 MB（0274P） ATCC29837 2pack JPY11,500 Sporidiobolus salmonicolor KWIK-STIKTM store at 2℃-8℃ 49844-44 MB（01013P） ATCCMYA-4550 2pack JPY13,500 Staphylococcus aureus KWIK-STIKTM store at 2℃-8℃ 49842-02 MB（0179P） ATCCBAA-1026 2pack JPY13,500 49844-45 MB（01007P） ATCCBAA-1708 2pack JPY13,500 49825-97 MB（0831P） NCTC6571 2pack JPY9,500 49820-66 MB（01065P） NCTC12493 2pack JPY11,500 49944-54 MB（01122P） ATCCBAA-2312 2pack JPY13,500 Staphylococcus aureus subsp.aureus KWIK-STIKTM Plus store at 2℃-8℃ 49945-76 MB（0906X） ATCC29737 2pack JPY45,000 General Catalog of Kanto Reagents, Chemicals & Biologicals + Oct. 2021 Staphylococcus aureus subsp.aureus EZ-Accu ShotTM store at 2℃-8℃ 49844-66 MB（0485A） ATCC6538 5test JPY46,000 49944-80 MB（0360A） ATCC25923 5test JPY46,000 49944-81 MB（0827A） ATCC6538P 5test JPY46,000 Staphylococcus aureus subsp.aureus EZ-CFUTM store at 2℃-8℃ 49820-23 MB（0485C） ATCC6538 10test JPY87,000 49820-25 MB（0360C） ATCC25923 10test JPY87,000 49820-24 MB（0827C） ATCC6538P 10test JPY87,000 Staphylococcus aureus subsp.aureus EZ-CFUTM One Step store at 2℃-8℃ 49840-95 MB（0485Z） ATCC6538 10test JPY86,000 49842-71 MB（0360Z） ATCC25923 10test JPY86,000 49842-72 MB（0827Z） ATCC6538P 10test JPY86,000 Staphylococcus aureus subsp.aureus EZ-PECTM store at 2℃-8℃ 49840-82 MB（0485PEC） ATCC6538 10piece JPY114,000 49946-04 MB（0360-PEC） ATCC25923 10test JPY114,000 General Catalog of Kanto Reagents, Chemicals & Biologicals + Oct. 2021 Staphylococcus aureus subsp.aureus KWIK-STIKTM store at 2℃-8℃ 49824-17 MB（0485P） ATCC6538 2pack JPY11,500 49840-68 MB（0113P） ATCC9144 2pack JPY14,500 49824-19 MB（0462P） ATCC11632 2pack JPY11,500 49842-03 MB（0173P） ATCC12600 2pack JPY14,500 49824-20 MB（0360P） ATCC25923 2pack JPY8,500 49824-21 MB（0365P） ATCC29213 2pack JPY8,500 49824-22 MB（0906P） ATCC29737 2pack JPY11,500 49824-23 MB（0496P） ATCC33591 2pack JPY11,500 49825-96 MB（0889P） ATCC33592 2pack JPY9,500 49824-24 MB（0352P） ATCC33862 2pack JPY9,500 49824-25 MB（0852P） ATCC43300 2pack JPY11,500 49824-27 MB（0937P） ATCC49476 2pack JPY13,500 49824-28 MB（0832P） ATCC51153 2pack JPY13,500 49842-04 MB（0159P） ATCC51740 2pack JPY14,500 49844-67 MB（01022P） ATCC700698 2pack JPY14,500 49842-05 MB（0158P） ATCC700699 2pack JPY13,500 49824-18 MB（0827P） ATCC6538P 2pack JPY11,500 49820-34 MB（01055P） ATCCBAA-44 2pack JPY13,500 49842-06 MB（0146P） ATCCBAA-976 2pack JPY11,500 49842-07 MB（0147P） ATCCBAA-977 2pack JPY11,500 49844-10 MB（0713P） NCTC12973 2pack JPY11,500 49944-56 MB（0312P） NCIMB12702 2pack JPY8,500 Staphylococcus aureus subsp.aureus KWIK-STIKTM Plus store at 2℃-8℃ 49839-09 MB（0485X） ATCC6538 5pack JPY45,000 49842-48 MB（0360X） ATCC25923 5pack JPY45,000 49820-73 MB（0852X） ATCC43300 5pack JPY45,000 49842-49 MB（0827X） ATCC6538P 5pack JPY45,000 General Catalog of Kanto Reagents, Chemicals & Biologicals + Oct. 2021 Staphylococcus capitis KWIK-STIKTM store at 2℃-8℃ 49843-16 MB（0533P） ATCC146 2pack JPY16,500 Staphylococcus capitis subsp.capitis KWIK-STIKTM store at 2℃-8℃ 49824-30 MB（0963P） ATCC35661 2pack JPY11,500 Staphylococcus epidermidis EZ-Accu ShotTM store at 2℃-8℃ 49944-82 MB（0371A） ATCC12228 5test JPY46,000 Staphylococcus epidermidis EZ-CFUTM store at 2℃-8℃ 49820-26 MB（0371C） ATCC12228 10test JPY87,000 Staphylococcus epidermidis EZ-CFUTM One Step store at 2℃-8℃ 49842-73 MB（0371Z） ATCC12228 10test JPY86,000 Staphylococcus epidermidis KWIK-STIKTM store at 2℃-8℃ 49824-32 MB（0371P） ATCC12228 2pack JPY9,500 49824-33 MB（0412P） ATCC14990 2pack JPY9,500 49824-34 MB（0628P） ATCC49134 2pack JPY11,500 49824-35 MB（0976P） ATCC49461 2pack JPY11,500 49820-67 MB（01068P） ATCC51625 2pack JPY14,500 49945-61 MB（01189P） ATCC35984 2pack JPY14,500 49944-58 MB（0571P） NCIMB8853 2pack JPY11,500 General Catalog of Kanto Reagents, Chemicals & Biologicals + Oct. 2021 Staphylococcus epidermidis KWIK-STIKTM Plus store at 2℃-8℃ 49842-50 MB（0371X） ATCC12228 5pack JPY45,000 Staphylococcus gallinarum KWIK-STIKTM store at 2℃-8℃ 49824-45 MB（0629P） ATCC49148 2pack JPY14,500 Staphylococcus haemolyticus KWIK-STIKTM store at 2℃-8℃ 49840-01 MB（0246P） ATCC29970 2pack JPY14,500 Staphylococcus lentus KWIK-STIKTM store at 2℃-8℃ 49840-02 MB（0739P） ATCC700403 2pack JPY13,500 Staphylococcus lugdunensis KWIK-STIKTM store at 2℃-8℃ 49840-03 MB（0217P） ATCC49576 2pack JPY9,500 49944-59 MB（01150P） NCTC7990 2pack JPY13,500 Staphylococcus pseudintermedius KWIK-STIKTM store at 2℃-8℃ 49824-26 MB（0907P） ATCC49444 2pack JPY11,500 General Catalog of Kanto Reagents, Chemicals & Biologicals + Oct. 2021 Staphylococcus saprophyticus KWIK-STIKTM store at 2℃-8℃ 49824-36 MB（0494P） ATCC15305 2pack JPY9,500 49844-70 MB（01035P） ATCC35552 2pack JPY13,500 49824-37 MB（0945P） ATCC49453 2pack JPY13,500 49824-38 MB（0881P） ATCC49907 2pack JPY13,500 49842-09 MB（0134P） ATCCBAA-750 2pack JPY9,500 Staphylococcus saprophyticus KWIK-STIKTM Plus store at 2℃-8℃ 49945-77 MB（0134X） ATCCBAA-750 2pack JPY45,000 Staphylococcus sciuri subsp.sciuri KWIK-STIKTM store at 2℃-8℃ 49840-05 MB（0764P） ATCC29061 2pack JPY13,500 Staphylococcus warneri KWIK-STIKTM store at 2℃-8℃ 49824-42 MB（0946P） ATCC49454 2pack JPY11,500 Staphylococcus xylosus KWIK-STIKTM store at 2℃-8℃ 49824-43 MB（0605P） ATCC29971 2pack JPY13,500 49840-08 MB（0741P） ATCC700404 2pack JPY13,500 General Catalog of Kanto Reagents, Chemicals & Biologicals + Oct. 2021 Stenotrophomonas maltophilia KWIK-STIKTM store at 2℃-8℃ 49844-56 MB（01020P） ATCC13636 2pack JPY13,500 49824-46 MB（0369P） ATCC13637 2pack JPY11,500 49840-09 MB（0759P） ATCC17666 2pack JPY11,500 49840-69 MB（0135P） ATCC49130 2pack JPY9,500 49840-10 MB（0742P） ATCC51331 2pack JPY13,500 Stenotrophomonas maltophilia KWIK-STIKTM Plus store at 2℃-8℃ 49842-52 MB（0369X） ATCC13637 5pack JPY45,000 49945-78 MB（0759X） ATCC17666 2pack JPY45,000 Streptococcus agalactiae (III) KWIK-STIKTM store at 2℃-8℃ 49945-62 MB（01234P） ATCCBAA-22 2pack JPY11,500 Streptococcus agalactiae KWIK-STIKTM store at 2℃-8℃ 49824-73 MB（0439P） ATCC12386 2pack JPY11,500 49842-11 MB（0104P） ATCC12403 2pack JPY16,500 49824-47 MB（0370P） ATCC13813 2pack JPY9,500 49824-48 MB（0436P） ATCC27956 2pack JPY9,500 49842-10 MB（0105P） ATCCBAA-611 2pack JPY13,500 49843-92 MB（0480P） NCTC8017 2pack JPY11,500 49844-12 MB（0710P） NCTC9993 2pack JPY14,500 49944-61 MB（0709P） NCIMB701348 2pack JPY11,500 49824-72 MB（0864P） ATCC12401 2pack JPY11,500 General Catalog of Kanto Reagents, Chemicals & Biologicals + Oct.
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    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/185925 Al 20 November 2014 (20.11.2014) P O P C T (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BOW 53/28 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, PCT/US20 13/04 1503 KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (22) International Filing Date: ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 17 May 2013 (17.05.2013) NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (25) Filing Language: English TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (26) Publication Language: English ZM, ZW. (71) Applicant: EMPIRE TECHNOLOGY DEVELOP¬ (84) Designated States (unless otherwise indicated, for every MENT LLC [US/US]; 271 1 Centerville Road, Suite 400, kind of regional protection available): ARIPO (BW, GH, Wilmington, Delaware 19808 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: PEPPOU, George Charles; 4 Armen Way, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Hornsby Heights, New South Wales 2077 (AU).
  • (12) United States Patent (10) Patent No.: US 6,270,722 B1

    (12) United States Patent (10) Patent No.: US 6,270,722 B1

    USOO6270722B1 (12) United States Patent (10) Patent No.: US 6,270,722 B1 Yang et all e 45) Date of Patent:e Aug. 7, 2001 (54) STABILIZED BROMINE SOLUTIONS, (56) References Cited METHOD OF MANUFACTURE AND USES THEREOF FOR BOFOULING CONTROL U.S. PATENT DOCUMENTS 3,328.294 6/1967 Self et al.. (75) Inventors: Shunong Yang; William F. McCoy, 3,558,503 1/1971 Goodenough et al.. both of Naperville; Eric J. Allain, 3,767,586 10/1973 Rutkiewic et al.. Aurora; Eric R. Myers, Aurora; 5,683,654 11/1997 Dalmier et al.. Anthony W. Dalmier, Aurora, all of IL 5,795,487 8/1998 Dalmier et al.. (US) 6,007,726 * 12/1999 Yang et al. ........................ 422/37 X 6,015,782 1/2000 Petri et al. ........................... 510/379 (73) Assignee: Nalco Chemical Company, Naperville, 6,110,387 * 8/2000 Choudhury et al. ................. 210/752 IL (US) FOREIGN PATENT DOCUMENTS (*) Notice: Subject to any disclaimer, the term of this WO 97/20909 6/1997 (WO). patent is extended or adjusted under 35 WO 97/43392 11/1997 (WO). U.S.C. 154(b) by 0 days. * cited by examiner Primary Examiner Elizabeth McKane (21) Appl. No.: 09/283,122 (74) Attorney, Agent, or Firm-Kelly L. Cummings; (22) Filed: Mar. 31, 1999 Thomas M. Breininger (51) Int. Cl." ................................ A61L 2/16; C01B 709; (57) ABSTRACT D06L 3/06 Stabilized bromine Solutions are prepared by combining a (52) U.S. Cl. ..................................... 422/37; 422/6; 8/107; bromine Source and a Stabilizer to form a mixture, adding an 8/137; 162/1; 423/500; 252/187.2 oxidizer to the mixture, and then adding, an alkaline Source (58) Field of Search ...................................
  • Novel Reactions of Ceph-3-Ems

    Novel Reactions of Ceph-3-Ems

    NOVEL REACTIONS OF CEPH-3-EMS Jacqueline M Torrance B.Sc. (Hons) A thesis submitted in partial fulfilment of the requirements of the University of Abertay Dundee for the degree of Doctor of Philosophy June 1995 I certify that this thesis is the true and accurate version of the thesis approved by the examiners. Signed Date (Director of Studies) DECLARATION I hereby declare that the work presented in this thesis was carried out by me at University of Abertay Dundee, Dundee, except where due acknowledgement is made, and has not been submitted by me for any other degree. Signed Date CONTENTS 1 INTRODUCTION 1 1.1 INTRODUCTION 2 1.1.1 History of Penicillin 2 1.1.2 History of Cephalosporins 4 1.2 REACTIONS AT SULPHUR 7 1.2.1 Oxidation 7 1.2.2 De-oxygenation 13 1.3 REACTIONS AT C-2 15 1.3.1 2-Alkylcephems 15 1.3.2 2-Alkoxycephems 17 1.3.3 2-Exocyclic Cephems 22 1.4 REACTIONS AT C-3 30 1.4.1 3-Exomethylene 30 1.4.2 3-Vinyl-and 3-Allylcephalosporins 38 1.4.3 3-Azidocephems 42 1.4.4 3-Alkoxy- and 3-Alkylcephems 44 1.5 REACTIONS AT C-4 46 1.5.1 A2-Cephems 46 1.5.2 Addition to the A3-Double Bond 51 1.5.3 Reactions at the C-4 Carboxyl Group 54 1.5.4 Ester Formation and Deprotection 59 1.6 REACTIONS AT C-7 62 1.6.1 7a-Methoxycephalosporins 62 1.6.2 7a-Formamidocephalosporins 66 1.6.3 Other 7a-Substituents 69 ii 1.6.4 7-Spirocyclic Cephalosporins 71 1.6.5 Reactions at N-7 73 1.7 MISCELLANEOUS CEPHALOSPORIN REACTIONS 74 1.7.1 Conversion of Penicillin to Cephalosporins 74 1.7.2 Conversion of Cephalosporins to Penicillins 78 1.7.3 Tricyclics and Tetracyclics
  • Investigating Cell Type Specific Mechanisms Contributing to Acute Oral Toxicity

    Investigating Cell Type Specific Mechanisms Contributing to Acute Oral Toxicity

    Prieto et al.: Investigating cell type specific mechanisms contributing to acute oral toxicity Supplementary Data1 Tab. S1: Overview of collected information on specific target organ/system and general cytotoxicity for chemicals correctly assigned to the CLP acute oral toxicity category by the 3T3 NRU cytotoxicity assay General Nervous Cardiovascular GI Chemical Liver Lung Blood Kidney cytotoxicity system system system (±)-Propranolol hydrochloride x ax (4-ammonio-m-tolyl)ethyl(2- x x hydroxyethyl)ammonium sulphate 1,2,4-Trichlorobenzene x x 1,2-Dichlorobenzene x x 2,4,6- x x Tris(dimethylaminomethyl)phenol 2,4-Dichlorophenoxyacetic acid x x x 5,5-Diphenylhydantoin x x 5-Fluorouracil x x x x Acetophenone x Acetylsalicylic acid x x x x x x Acrolein x x Acrylamide x x x Ammonium chloride x ax ax Atropine sulfate monohydrate x x Benzaldehyde x x Cadmium (III) chloride x x x x x Caffeine x x x Chloroform x x ax x x x x Chloroquine bis(phosphate) x x Chlorpromazine x x x Codeine x x x x Colchicine x x x x Copper sulphate x x x Cupric sulfate pentahydrate x x Cyclosporin A x x x x Diazepam x Diphenhydramine hydrochloride x x Disopyramide x x Ethyl chloroacetate x x Ferrous sulphate x x x Glufosinate-ammonium x Glutethimide x ax x Hexachlorophene x x Lithium Carbonate x x x Lithium sulphate x x x Malathion x x Maleic acid x x Meprobamate x x Orphenadrine hydrochloride x x x x p-Benzoquinone x x x Phenol x x x x x Procainamide hydrochloride x x x Quinidine sulfate dehydrate x x x Resorcinol x x Rifampicin x x doi:10.14573/altex.1805181s2 ALTEX ##(#), SUPPLEMENTARY DATA 1 General Nervous Cardiovascular GI Chemical Liver Lung Blood Kidney cytotoxicity system system system Sodium Cyanate x x sodium oxalate x x x Sodium valproate x bx x x Thioridazine hydrochloride x x Valproic acid x x x x x GI: Gastrointestinal; CLP: Classification, labelling and packaging; NRU: Neutral Red Uptake; a Indirect effect: b chronic effect Tab.
  • United States Patent Office Patented Apr

    United States Patent Office Patented Apr

    3,509,255 United States Patent Office Patented Apr. 28, 1970 1. 2 biotics Annual, 1953-1954, pages 191-194, Medical En 3,509,255 cyclopedia, Inc., New York, N.Y. PROCESS FOR THE RECRYSTALLIZATION The recovery of nystatin by isopropanol extraction of OF NYSTATIN Harold Mendelsohn, Nanuet, N.Y., assignor to American the whole broth resulting from the fermentation of the Cyanamid Company, Stamford, Conn., a corporation of nystatin producing Streptomyces noursei is described in Maine U.S. Patent No. 2,786,781 to Vandeputte et al. The par No Drawing. Filed July 2, 1968, Ser. No. 741,912 tially purified product obtained by the Vandeputte et al. Int. Cl. A61k 21/00 process is a therapeutically useful product of about 65 U.S. C. 424-123 10 Claims 70% purity. At best, however it is only partially crystal line and for the most part is substantially non-crystalline or amorphous in character. The purification of nystatin ABSTRACT OF THE DISCLOSURE employing methanolic-calcium chloride is also described This disclosure describes a process for preparing highly in U.S. Patent No. 2,832,719 to Vandeputte and in U.S. purified crystalline nystatin by extracting crude nystatin Patent No. 2,865,807 to Dutcher et al. The product ob with acetone which is saturated with sodium iodide, 15 tained by the Vandeputte and Dutcher et al. processes is Sodium thiocyanate, potassium thiocyanate or ammonium a therapeutically useful highly refined product substan thiocyanate; and precipitating highly purified crystalline tially crystalline in character. nystatin from the extract by displacement of the acetone The processes described above produce crystalline ny with water.