Facts and Figures

RESEARCH

EDUCATION

PATIENT CARE

COMMUNITY PARTNERSHIPS

GLOBAL OUTREACH Anesthesiology Community and Family Medicine CLINICAL Dermatology Medicine The youngest of the nation’s leading SCIENCE DUKE Neurology medical schools, School DEPARTMENTS UNIVERSITY Neurosurgery of Medicine is one of the nation’s premier Obstetrics and Gynecology SCHOOL OF schools for medical education, clinical Ophthalmology MEDICINE care and biomedical research. Planning Orthopaedic Surgery Pathology for the school began in 1925, when Pediatrics businessman , benefactor of Duke Psychiatry & Behavioral Sciences University and The Duke Endowment, bequeathed $4 million Radiation Oncology to establish the Duke School of Medicine, the Duke School Radiology of Nursing and Duke . Less than five years after the Surgery school opened in 1930, the Association of American Medical Colleges ranked Duke in the top quarter of medical schools in

the country. Now, more than 80 years later, the Duke University Biochemistry School of Medicine is still ranked among the leading medical Biostatistics & Bioinformatics BASIC schools in the nation. The School of Medicine employs more Cell Biology SCIENCE than 2,200 regular rank faculty physicians and researchers. Immunology DEPARTMENTS Molecular Genetics and Microbiology The School of Medicine, Duke University Health System, Neurobiology School of Nursing, and the PDC comprise Duke Health. Pharmacology and Biology Population Health Sciences

Brain Imaging and Analysis Center Center for Genomic & Computational Biology Dean: Mary E. Klotman, M.D. CENTERS, Center for Human Disease Modeling Address: Office of the Dean, INSTITUTES, Center for the Study of Aging and Human DUMC 2927, Durham, NC 27710 AND Development School Web Address: medschool.duke.edu Duke Cancer Institute Twitter: @DukeMedSchool INITIATIVES Duke Clinical and Translational Science Institute @MaryEKlotman Duke Clinical Research Institute Duke Global Health Institute Duke Human Vaccine Institute Duke Institute for Brain Sciences Duke Molecular Physiology Institute MEDx Regeneration Next Trent Center for Bioethics, Humanities and History of Medicine

2 Robert Lefkowitz, MD, professor of medicine and a Howard Hughes Medical Institute investigator, has spent his entire 44-year research career at Duke. FACULTY In 2012, he was awarded the Nobel Prize in Chemistry with Brian K. Kobilka, MD, of Stanford University School of Medicine, who was a post-doctoral fellow in Dr. Lefkowitz’s lab in the 1980s. They were recognized Total Regular Rank faculty 2,202 for their work on a class of cell surface receptors that NOBEL have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve LAUREATES hypertension, angina and coronary disease.

Paul Modrich, PhD, professor of biochemistry and a Howard Hughes Medical Institute investigator, was awarded the Nobel Prize in Chemistry in 2015 along with Tomas Lindahl, MD, PhD, of the Francis Crick Institute and Clare Hall Laboratory in the UK, and Aziz Sancar, MD, PhD, of University of at Chapel Hill, for mechanistic studies of DNA repair. The trio was honored for mapping, at a molecular level, how cells repair damaged DNA and safeguard the genetic information. According to the Nobel Foundation, their work has provided fundamental knowledge of how a living cell functions and is, for instance, used for the development of new cancer treatments. 14 National Academy of Sciences MEMBERSHIPS 25 National Academy of Medicine 4 HHMI investigators and early career scientists (present)

16 American Academy of Arts and Sciences

40 Association of American Physicians

64 American Society for Clinical Investigation

133 Faculty holding distinguished professorships (does not include emeriti)

MD Alumni (Living) 5,665

3 42 EDUCATION

• The Duke University School of Medicine’s science and engineering although unique curriculum allows medical students have earned their PhD degrees students to study the core basic sciences in the social sciences as well. Of the for one year instead of two, giving 46 such programs funded by the them the opportunity to devote their National Institutes of Health (NIH), entire third year to a scholarly research the Duke MSTP was the fourth program project. Students care for patients during established in 1966. their second year core rotations, a full year earlier than peers at most other • Established in 1965, the Physicians medical schools. Assistant Program at Duke is recognized as the birthplace of the PA profession. • The School of Medicine offers a unique The program has been consistently ranked 4-year Primary Care Leadership Track to as one of the top programs in the nation, train leaders who can enter residency and currently is ranked No. 1 by U.S. News prepared to engage with communities & World Report. and practices to help improve health outcomes. The track builds on the • Housed within the Duke Department longstanding partnership between Duke of Orthopaedic Surgery, the Doctor and the Durham community so students of Physical Therapy (DPT) program at Duke is committed to producing the The School of Medicine can better understand causes of health disparities, create a strong research next generation of leaders in the field The School of Medicine includes the research focus on community engagement, and of physical therapy. This program also efforts of basic and clinical faculty members in learn how to redesign clinical programs is consistently ranked among the best 37 departments, centers and institutes. Their to better serve the patient needs. training programs in the nation, most combined efforts make Duke one of the largest recently ranked No. 10 in the country biomedical research enterprises in the country, • In 2015, the School of Medicine launched by U.S. News & World Report. the Master of Biomedical Sciences with nearly $700 million in sponsored research program. During this one-year program, • The School of Medicine offers education expenditures annually. RESEARCH students learn the language of human programs internationally as well. medicine as well as the context of clinical Duke-NUS Graduate During Fiscal Year 2017, nearly 18,000 patients care. The goal of the program is to Singapore (Duke-NUS) is renowned for participated in 1,552 active clinical research enhance the scientific and professional its pioneering approach to team-based studies at Duke. preparation of students aspiring to learning and its signature research a career in the health professions or in programs. Its inaugural class matriculated in August 2007 and graduated in 2011 with Duke is home to the world’s largest academic a related field requiring graduate level biomedical sciences. joint MD degrees from Duke and NUS. In clinical research organization, the Duke Clinical 2010, the school launched a PhD program. Research Institute, which has conducted studies • Approximately 16 percent of Duke , a Sino-American at more than 37,000 sites in 65 countries, medical students are enrolled in the partnership of Duke University and Wuhan enrolling more than 1.2 million patients and Medical Scientist Training Program University, offers a range of academic generating more than 7,300 publications in (MSTP), which culminates in both a programs including a Master of Science in medical degree (MD) and a doctoral Medical Physics degree for students from peer-reviewed journals. degree (PhD). The majority of MSTP China and throughout the world. students pursue degrees in biomedical

DUKE HAS BLAZED TRAILS IN MEDICINE FOR MORE THAN SEVEN DECADES.

1936 1950 1959 1968 1981 1982  Duke surgeon J. Deryl  Duke pediatrician,  Duke becomes first to use  Irwin Fridovich, PhD, and  Duke biophysicist Jane  Pediatric immunologist Hart, MD, introduces Jay Arena, MD, leads the systemic hypothermia graduate student Joe Richardson’s ribbon Rebecca Buckley, MD, ultraviolet lamps into push for drug companies during cardiac surgery. McCord discover the diagram, a method uses bone marrow operating rooms to kill to develop the child- This technique of cooling enzyme superoxide of representing the 3D transplantation to cure airborne germs that proof safety cap for patients to minimize tissue dismutase, which protects structure of proteins, severe combined cause post-operative staph medicine bottles. damage during lengthy all living things against is first immunodeficiency, also infections dramatically surgical procedures the toxicity of oxygen. published. known as “bubble reducing the number is now standard boy disease.” of infections and practice worldwide.

5 related deaths. 6

STUDENTS

484 MD Students 665 Health Professional Students (PA, Pathology Assistant, Clinical Research Program, Clinical Leadership Program, Masters in Biostatistics, Doctor of Physical Therapy, Ophthalmic Tech, Masters in Medical Physics)

519 PhD Students in biomedical programs (MSTP students included)

1,043 Graduate Medical Education (Residents and Fellows) 332 Students at Duke-NUS Graduate Medical School (2017-18) (MD, MD/PhD, PhD students) 47 Duke Kunshan University (Master of Science in Medical Physics Program, Master of Science in Global Health Program)

7,030 AMCAS Applications 116 Students Applications to all biomedical graduate education programs 2017 66 women, 49 men, 1 unspecified are submitted to the Duke Graduate School. These programs are administered in the School of Medicine by the Office of Biomedical 36/518 Median MCAT ENTERING Graduate Education. CLASS 3.85 Median Overall GPA 3.85 Median Science GPA Biochemistry (MD PROGRAM) • 13% Under-represented minority students Biostatistics & Bioinformatics PHD • 37 States Represented Cell and Molecular Biology PROGRAMS • 59 Undergraduate Institutions • Cell Biology • Cognitive Neuroscience • Computational Biology and Bioinformatics Developmental & Stem Cell Biology Doctor of Medicine (MD) • HEALTH EDUCATION • Immunology Medical Scientist Training Program (MD/PhD) • PROGRAMS • Integrated Toxicology & Environmental Health Doctor of Physical Therapy Program (DPT) • • Medical Physics Physician Assistant Program (MHS) • • Molecular Cancer Biology Clinical Leadership Program (MHS) • • Molecular Genetics & Microbiology Clinical Research Training Program (MHSc) • • Neurobiology Master of Biomedical Sciences • • Pathology Master of Biostatistics • • Pharmacology Master of Management in Clinical Informatics • • • University Program in Genetics & Genomics • Master of Science in Medical Physics • Pathologists’ Assistant Program (MHS)

1985 1990 1990s 1993 1994 1998  Duke becomes one of two Duke researchers discover  Duke geneticists invent Duke Comprehensive Pediatric immunologist Duke researchers are the first to conduct the a gene that increases a three-minute test to Cancer Center (now Louise Markert, MD, PhD, to use magnetic resonance first human clinical trials people’s risk of developing screen newborns for over 30 Duke Cancer Institute) uses thymus transplantation spectroscopy to track levels of AZT, the first drug to the most common form of metabolic diseases at once. develops the nation’s to cure once-fatal complete of n-acetylaspartate (N-AA) substantially improve Alzheimer’s disease, Though devastating if first outpatient bone DiGeorge Syndrome. as a marker for Alzheimer’s quality of life for showing for the first time undetected, the diseases can marrow transplantation disease, proving that such Duke scientists help to AIDS patients. that it can be inherited. be controlled once identified. program. a marker exists and that it discover BRCA1, the gene The test is now used can be detected via MRS. responsible for many throughout the country. inherited forms of breast and ovarian . 7 8 DUKE UNIVERSITY HEALTH SYSTEM

Total figures for Duke Regional Hospital Duke University Health System Duke Duke and Davis Duke including Duke University Hospital, Duke University Raleigh Ambulatory Primary Regional Hospital, Duke Raleigh Hospital, Hospital Hospital Surgical Center Care and Duke Primary Care for fiscal year 2016.

Outpatient Visits 1,119,151 190,846 123,234 647,084 Outpatient Visits 2,080,315

Inpatient Admissions 41,562 8,985 15,538 Visits 186,209 (excludes newborns) Patients transported by LifeFlight 887 Surgical Procedures 39,781 15,244 13,799 (excludes ground) (excludes endoscopies) Number of Surgical Cases 68,824 (excludes endoscopies) Employees (full-time): 15,893 within Duke Babies Delivered 5,696 University Health System (FY16)

Duke University Hospital Cardiac Catheterizations 6,403 • (adult/pediatric/mobile) • Duke Regional Hospital Duke Raleigh Hospital Open Heart Surgeries 1,376 • (adult/pediatric) • Duke HomeCare & Hospice • Duke Primary Care Organ Transplant Kidney 140 Duke Health & Wellness • Lung 96 • Affiliated Programs – Through the Duke Heart 70 Heart Network, Duke Oncology Network, Liver 98 Duke Neonatology Network, Duke Infection Pancreas, Intestine and 19 Control Outreach Network, and Duke/ multi-organ transplants LifePoint partnership, Duke Health has established clinical and research affiliations with community hospitals to benefit patients throughout the Southeast.

Employees (full-time): 1,250 in the Private Diagnostic Clinic (FY16)

2003 2005 2006 2011 2012 2013  Duke researchers  Researchers at Duke and  The FDA approves Hai Yan, MD, PhD, and a Bart Haynes, MD, leads demonstrate for the Vanderbilt universities Myozyme, the first team of scientists from the world’s largest HIV Physician-scientist Jeffery first time that magnetic discover the first major lifesaving treatment for Duke and Johns Hopkins vaccine trial, which Lawson, MD, PhD, and Laura resonance technology gene known to determine children with Pompe universities identify provides important clues Niklason, MD, PhD, develop could be used to observe an individual’s risk for disease. The treatment mutations in a gene that about immune system a bioengineered blood vessel, the effects of a medication developing age-related was discovered and make cells immortal and responses that could play which Lawson grafts into an on brain structures, macular degeneration, the developed at Duke. appear to play a pivotal a role in protecting people artery in a Duke patient’s arm, an important first step leading cause of visual role in three of the most from HIV infection. the first in-human procedure toward improving drug impairment and legal common types of brain of its kind in the United States. research for treating blindness in the elderly. tumors, as well as cancers Duke Receives $47 Million Alzheimer’s disease. of the liver, Award from NIH to support tongue and translational research. urinary tract.

9 10 COMMUNITY PARTNERSHIPS Duke works with many community partners to As a world-class academic and system, Duke Health improve health care locally. Examples of outreach strives to transform medicine and health locally and globally programs include: through innovative scientific research, rapid translation of • Primary Care Wellness Centers within four Durham breakthrough discoveries, educating future clinical and scientific public schools, serving mostly low-income youngsters leaders, advocating and practicing evidence-based medicine at George Watts Elementary, Glenn Elementary, EK to improve community health, and leading efforts to eliminate Powe Elementary, and Southern High Schools. Clinics health inequalities. In fiscal year 2016, DUHS provided$323.5 operate during the school year and provide medical and mental health services. The elementary school million in charity care and other community benefit investments. clinics also provide bilingual mental health services. All four Wellness Centers offer medical coverage during weekends and school holidays.

• Since 2002, Duke has hosted the Durham Health Summit. Health Summits raise awareness of key health issues identified by the community and provide a platform to develop collaborative solutions to improve health outcomes in our community.

• Partnership for a Healthy Durham is a coalition of local agencies and communities with the goal of collaboratively improving the physical, mental, and social health and well-being of Durham residents. The program is housed in the Durham County Department of Public Health and focuses on six health priorities: obesity and chronic illness; access to medical and dental care; mental health and substance abuse; HIV and sexually transmitted infections; poverty; and education.

• The Academic Success Through Surgical Education and Training (ASSET) program is a partnership between the Duke University Department of Surgery and the Durham Nativity School. Through the program, faculty members in the Department of Surgery train and mentor students. This program aims to foster high achievement in science through surgical education for financially disadvantaged students.

• The City of Medicine Academy is a unique high school located in Durham that provides students 2014 2015 2016 2016 with a challenging academic program while A mind-controlled robotic  Duke researchers receive The FDA awards Duke A Duke team, led by Linda providing them with a broad overview of health exoskeleton developed by $15 million to support “breakthrough therapy Cendales, MD, performed professions and potential careers in medicine, Duke researcher Miguel an innovative research designation” for a poliovirus the first hand transplant science, and research. Resources across Duke Nicolelis, MD, program that explores the therapy for glioblastoma. in NC, attaching the limb PhD, is used use of umbilical cord blood The therapy was developed to a 54-year-old patient University, the School of Medicine, and the Health by a paraplegic cells to treat autism, stroke, and is being tested from Laredo, Texas, whose System help maximize the student’s learning man to make cerebral palsy and related by researchers at Duke’s hand was severed in a experience through summer internships, field trips, a first kick at brain disorders. Preston Robert Tisch childhood accident. and after school. Duke University School of Medicine the Opening Brain Tumor Center. and Health System faculty, staff and students lend Ceremonies of their expertise to projects and classroom lectures. the World Cup.

11 12 GLOBAL OUTREACH

STUDENT FIELD Total number of student project placements in 2017: 119 student PROJECTS projects in 26 countries

1.   Become the worldwide leader in interdisciplinary global health education DGHI’S 2.  Catalyze and conduct innovative research that PRIMARY responds to the changing global burden of disease and influences policy GOALS

3.  Create a robust network of international partners to exchange global health knowledge and skills

DGHI’s education, research, and capacity building initiatives are built on a strong network PRIORITY of partnerships with institutions around the world in Priority Partnership Locations. These PARTNERSHIP partnerships provide opportunities for faculty LOCATIONS and students and are based on bidirectional, Duke’s Global Health Institute (DGHI) is a university-wide effort to address mutually-beneficial relationships. DGHI has invested in capacity-building, research, and health disparities worldwide through multidisciplinary research, education, education program development in a number policy engagement, and service. It is one of many institutes that comprise of strategically-important locations: the School of Medicine. • Beijing, China DGHI’s research priorities include emerging • Kunshan, China infectious diseases; environmental health; • RESEARCH health systems strengthening; cardiovascular • Shanghai, China disease and obesity; maternal, adolescent • Leogane, Haiti and child health; mental health and cancer. • Delhi, India Eldoret, Kenya • Thirty Six percent of the DGHI faculty • members are from the School of Medicine. • Lima, Peru • Singapore • DGHI faculty members are • Galle, Sri Lanka leading more than 150 active • Cape Town, South Africa global health research projects Moshi, Tanzania in more than 50 countries. • • Kampala, Uganda

13 14 • Excellence in education, research and patient care CORE VALUES OF • Respect for and inclusion of people DUKE UNIVERSITY from all backgrounds SCHOOL OF MEDICINE • Commitment to service, solving real world problems • Sense of urgency in transforming discoveries into improved human health

Printed August 2017