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Health & Medicine Research WEDNESDAY, MARCH 30, 2016 HEALTH & MEDICINE RESEARCH DAY HEALTH & MEDICINE RESEARCH DAY WEDNESDAY, MARCH 30, 2016 MARVIN CENTER MARVIN CENTER 800 21ST STREET, NW, 3RD FLOOR 800 21ST STREET, NW, 3RD FLOOR 8:00–9:00 a.m. Posters Setup (Grand and Continental Ballrooms) 12:00–2:00 p.m. Distribution of Box Lunches (MC 310) 12:30–3:00 p.m. Poster Presentations and Judging JACK MORTON AUDITORIUM (Grand and Continental Ballrooms) 805 21ST STREET, NW 3:00–4:00 p.m. Awards Ceremony and Oral Presentations (includes 10-minute presentations by winners of oral 8:00–9:00 a.m. Registration and Breakfast competition awards) (MC 309) 9:00–9:05 a.m. Welcome to Research Days 2016 Jeffrey S. Akman, MD Vice President for Health Affairs and Dean, MILKEN INSTITUTE SCHOOL OF School of Medicine and Health Sciences PUBLIC HEALTH BUILDING 9:05–9:10 a.m. Introduction of Keynote Address 950 NEW HAMPSHIRE AVENUE, NW, 1ST FLOOR AUDITORIUM Catherine Bollard, MD, FRACP, FRCPA Professor of Pediatrics and Microbiology, Immunology 4:30–4:35 p.m. Welcome Video & Introduction of Keynote Address and Tropical Medicine, School of Medicine and Health Sciences; Director, Program for Cell Lynn R. Goldman, MD, MS, MPH Enhancement and Technologies for Immunotherapy Michael and Lori Milken Dean, Milken Institute School (CETI), Children’s National Health System of Public Health; Professor of Environmental and Occupational Health 9:10–10:00 a.m. Keynote Address Kimberly Horn, EdD, MSW Stanley R. Riddell, MD Associate Dean for Research, Milken Institute School Fred Hutchinson Cancer Research Center, Clinical of Public Health; Professor of Prevention and Research Division; Professor of Oncology, University of Community Health Washington School of Medicine 4:35–5:15 p.m. Keynote Address “Designing Safe and Effective T-Cell Therapy for Cancer” Brian A. King, PhD, MPH 10:00–10:30 a.m. Coffee break Deputy Director for Research Translation, Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers 10:30–11:30 a.m. William Beaumont Research Award Oral for Disease Control and Prevention Presentations “Public Health Promise or Peril? The rise of Moderators: Ajlan Al Zaki, PhD, and James Boddu e-cigarettes and implications for tobacco control Siyang Chaili policy, planning, and practice” “Efficacy of IV Kinocidins in a Neutropenic Murine Model of Multi-Drug-Resistant Acinetobacter 5:15–5:30 p.m. Award Ceremony for the Milken Institute School of barman (MDRAB) Pneumonia” Public Health Reception to Follow Nicole Doria “Cutaneous Infection with Leishmania major Mediates Heterologous Protection against Visceral Infection with Leishmania infantum” Angeline Pham “Hypoxia Results in White Matter Immaturity in a Piglet Model of Congenital Heart Disease” MARCH 30, 2016 3:00–4:00 p.m. AWARDS CEREMONY SCHOOL OF MEDICINE SCHOOL OF NURSING 2016 DORIS DEFORD SPECK AND HEALTH SCIENCES, AND GEORGE SPECK, MD Moderator: Pamela Jeffries, PhD, RN, DONALD H. GLEW PRIZE FAAN, ANEF ENDOWED PRIZE Moderator: Lawrence Deyton, MSPH, MD Dean, School of Nursing Moderator: W. Scott Schroth, MD, MPH Senior Associate Dean for Clinical Associate Dean for Administration, Ann Hoffman: Public Health, School of Medicine School of Medicine and Health “Adverse childhood experiences and binge and Health Sciences Sciences drinking as an adult” Alexa Lean: Sarah Himmelfarb: “Circulating miRNA Biomarkers in Early Breast “Site-Specific Commensal Control of Cancer Detection Following Mammography” RESIDENT ORAL PRESENTATION T Effector Function in Human and Moderator: Robert H. Miller, PhD Non-Human Primate Skin” Senior Associate Dean for INSTITUTE FOR Research, School of Medicine Ria Roberts: BIOMEDICAL SCIENCES and Health Sciences “Is there Pandemic Vitamin D Deficiency in the Black Population? A review of Evidence” Moderator: Linda Werling, PhD Case Report: Associate Dean for Graduate Studies, Ivy Haskins, MD School of Medicine and Health “Exercise-related transient abdominal POSTER AWARD Sciences; Director, Institute for pain (ETAP)s” WINNERS ANNOUNCED Biomedical Sciences School of Medicine and Health Sciences Eshini Panditharatna: GRADUATE MEDICAL “Identification of Driver Mutations in Diffuse Institute for Biomedical Sciences EDUCATION RESEARCH Intrinsic Pontine Glioma Using Comprehensive Biomedical Engineering Spatial & Temporal Molecular Studies” COMPETITION WINNERS School of Nursing Clinical Science: DEPARTMENT OF Ivy Haskins, MD “The Use of Mesh in Emergent Ventral MILKEN INSTITUTE SCHOOL BIOMEDICAL ENGINEERING Hernia Repair: Effects on Early Patient Morbidity and Mortality” OF PUBLIC HEALTH POSTER Moderator: Vesna Zderic, PhD AND ONLINE VIDEO AWARD Associate Professor of Engineering Basic Science: and Applied Science WINNERS ANNOUNCED Yasmine Assadipour, MD 5:15–5:30 p.m. Ivan Suarez Castellanos: “Discovery and Characterization of an “Ultrasound stimulation of insulin release from Immunogenic Mutation in a Patient with Metastatic Triple Negative Breast Cancer” 950 New Hampshire Avenue, NW pancreatic beta cells” 1st Floor Auditorium Quality Improvement: Joseph Delio, MD Reception to Follow “Improving adherence to the United States Preventive Services Task Force (USPSTF) screening and immunization guidelines among residents at the internal medicine clinic within the GWU MFA group” OVPR_1516_8 TABLE OF CONTENTS Basic Biomedical Sciences Health Sciences Page 258 Page 460 Biomedical Engineering Health Services Page 284 Page 470 Cancer/Oncology HIV/AIDS Page 303 Page 483 Cardiology/Cardiovascular Research Immunology/Infectious Diseases Page 328 Page 493 Clinical Specialties Neuroscience Page 343 Page 508 Drug Abuse Obesity Page 391 Page 527 Education/Health Services Prevention Page 392 Page 531 Environmental & Occupational Sciences Psychiatry/Mental Health Page 408 Page 538 Epidemiology Quality Improvement Page 419 Page 542 Exercise & Nutrition Sciences Rehabilitation and Recovery Page 424 Page 567 Global Health Women/Child Health Page 436 Page 568 Health Policy Page 452 BASIC BIOMEDICAL SCIENCES INSTITUTE OF BIOMEDICAL SCIENCES STATUS Graduate Student Endurance exercise as a potential therapy for myositis: Uncovering the genetic basis for functional improvements AUTHORS using gene expression profiling Jessica Boehler Marshall W. Hogarth BACKGROUND The idiopathic inflammatory myopathies, or myositis, are a heterogeneous group of Svetlana Ghimbovschi muscle disorders characterized by proximal muscle weakness, immune cell infiltration Li Alemo Munters and abnormalities in energy metabolism. Recent studies have suggested that endurance exercise increases aerobic capacity and mitochondrial enzyme activity with a general clinical Ingela Loell improvement in patients; however, the molecular mechanisms behind this benefit are Yi-Wen Chen unknown. Helene Alexanderson OBJECTIVE Ingrid E. Lundberg Analyze skeletal muscle from exercised and non-exercised myositis patients to determine changes at the genetic level as a result of endurance exercise. Kanneboyina Nagaraju DESIGN/METHODS RESEARCH MENTOR/ Myositis patients were randomized into a 12-week endurance exercise group or a non- DEPARTMENT CHAIR exercised control group. Muscle biopsies from the vastus lateralis were collected before and Kanneboyina Nagaraju after the 12-week training program. Gene expression profiling was determined using the Affymetrix platform. Post intervention values were normalized to pre-intervention biopsies and a one-way ANOVA for exercised vs. control patients was used to determine significant changes. Data were filtered on p<0.05 with a fold change +/- 1.2. Gene lists were uploaded into Ingenuity Pathway Analysis (IPA) to identify commonly changed pathways due to exercise intervention. RESULTS/DISCUSSION Top canonical pathways that were changed in response to exercise include PEDF Signaling, Phosphatidylcholine Biosynthesis I, AMPK Signaling, ILK Signaling and Actin Cytoskeleton Signaling. A majority of these pathways are activated by inflammation and hypoxia and associated genes involved in promoting inflammation were down-regulated in response to exercise. Additionally, genes responsible for inhibiting angiogenesis were down regulated indicating exercise may improve oxygen transport to the muscle. Furthermore, genes involved in ILK and actin cytoskeletal signaling were down-regulated, which could signify a decrease in the cycles of degeneration and regeneration seen in myositis. Changes in gene expression that lead to more efficient oxygen transport to muscle with a decrease in inflammation and muscle degeneration, may explain the functional benefit seen in myositis patients after an endurance exercise intervention. 258 BASIC BIOMEDICAL SCIENCES INSTITUTE OF BIOMEDICAL SCIENCES STATUS Graduate Student Elucidating the mechanism of human amylin trafficking in the pancreatic b cells AUTHORS Diti Chatterjee Bhowmick Type 2 Diabetes Mellitus (T2DM) is a complex metabolic disorder characterized by progressive loss of pancreatic b-cells secretory functions, b-cells death, peripheral insulin Aleksandar Jeremic resistance and resulting hyperglycemia. Studies showed that, b-cell derived toxic aggregates of pancreatic hormone amylin contribute significantly towards the development of T2DM. The RESEARCH MENTOR/ human amylin (hA) is a 37 amino acid hormone, which shares similar biosynthesis mechanism DEPARTMENT CHAIR like insulin and is co-secreted with insulin by the pancreatic b-cells upon glucose stimulation. Aleksandar Jeremic However, the cellular processes that regulate hA mediated cytotoxicity is far from
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