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ĢENĒTISKIE IZMEKLĒJUMI Parauga Iedzimtās slimības SUŅIEM noņemšana EB 0,5-1 8166 Achromatopsia/ Day blindness (ACHM-Type 1)* Optigen ml/ SW Adult onset neuropathy* (AON) EB 0,5-1 8259 (English Cocker Spaniel) ml/ SW polyneuropathy (AMPN) EB 0,5-1 8479 (Alaskan Malamute) ml/ SW 8219 Brachyury - stumpy tail (, Australian Stumpy Tail Cattle , Austrian Pinscher, Bourbonnais Pointer, Brazilian Terrier, Brittany Spaniel, , EB 0,5-1 Danish/Swedish Farmdog, Jack Russell Terrier, , , ml/ SW , Pyrenean Shepherd, Savoy Sheepdog, , Spanish Waterdog, , Welsh Corgi]) 8519 Canine multi-focal retinopathy (CMR)* Optigen (American Bulldog, Australian Shepherd, Boerboel, Bullmastiff, Cane Corso, Coton EB 0,5-1 de Tulear, Dogue de Bordeaux, English Mastiff, Great Pyrenee, ml/ SW , Perro de Presa Canario)

8575 Canine multiple system degeneration (CMSD) (Chinese EB 0,5-1 Crested, Kerry Blue Terrier) ml/ SW 8012 Canine Leucocyte Adhesion Deficiency (CLAD) EB 0,5-1 (Irish Red and White Setter, Irish Setter) ml/ SW 8073 Centronuclear myopathy (CNM) EB 0,5-1 (Great Dane, Labrador Retriever) ml/ SW 8120 Eye Anomaly* (CEA) (Chinese Crested, Kerry Blue Terrier, , , Longhaired EB 0,5-1 Whippet, Nova Scotia Duck, Tolling Retriever, Rough / , ml/ SW ) 8256 Cone Degeneration (CD)* Optigen EB 0,5-1 (Alaskan Malamute, Australian Shepherd, German Shorthair) ml/ SW 8034 Copper Toxicosis (CT) EB 0,5-1 (Bedlington Terrier) ml/ SW 8011 CSNB / Night Blindness EB 0,5-1 ml/ SW 8013 Cystinuria EB 0,5-1 (Newfoundland, Landseer) ml/ SW 8466 Cystinuria EB 0,5-1 (Miniature Pinscher) ml/ SW 8434 Congenital Hypothyroidism with goiter (CHG) EB 0,5-1 (Spanish Waterdog) ml/ SW 8484 Ectodermal Dysplasia/Skin Fragility Syndrome (ED/SFS) EB 0,5-1 (Chesapeake Bay Retriever) ml/ SW

27 Parauga Iedzimtās slimības SUŅIEM (turpin.) noņemšana 8260 Dandy-Walker-Like Malformation (DWLM) EB 0,5-1 () ml/ SW 8485 Degenerative Myelopathy (DM) Exon1 EB 0,5-1 (Bernese Mountain Dog) ml/ SW 8158 Degenerative Myelopathy (DM) Exon2 EB 0,5-1 (All breeds) ml/ SW 8447 Degenerative Myelopathy (DM) Combination Exon1+2 EB 0,5-1 (Bernese Mountain Dog) ml/ SW 8472 Digital Hyperkeratosis (DH) EB 0,5-1 (Irish Terrier, Kromfohrländer) ml/ SW 8498 Digital Hyperkeratosis (DH/HFH) EB 0,5-1 (Dogue de Bordeaux) ml/ SW 8406 Dry Eye Curly Coat Syndrome (CCS) EB 0,5-1 (Cavalier King Charles Spaniel) ml/ SW 8407 Dry Eye Curly Coat Syndrome (CCS) + Episodic Falling (EF) EB 0,5-1 (Cavalier King Charles Spaniel) ml/ SW

8142 Dwarfism EB 0,5-1 (Saarloos Wolfdog, , Czechoslovakian Wolfdog) ml/ SW

8456 Dwarfism EB 0,5-1 (Labrador) ml/ SW 8152 Exercise Induced Collapse (EIC) (Boykin Spaniel, Chesapeake Bay Retriever, Curly Coated Retriever, German EB 0,5-1 Wirehaired Pointer, Labrador Retriever, , Pembroke ml/ SW Welsh Corgi) 8202 Episodic Falling (EF) EB 0,5-1 (Cavalier King Charles Spaniel) ml/ SW 8151 Factor VII Deficiency EB 0,5-1 (Beagle, Giant Schnauzer, Airedale Terrier, Scottish Deerhound, Alaskan Klee ml/ SW Kai) 8131 Familial Nephropathy* (FN) EB 0,5-1 (English Cocker Spaniel) ml/ SW 8192 Familial Nephropathy (FN) EB 0,5-1 (English Springer Spaniel, Samoyed) ml/ SW 8272 Fanconi Syndrome* EB 0,5-1 (Basenji) ml/ SW 8467 Finnish Hound Ataxie (FHA) EB 0,5-1 (Finnish Hound) ml/ SW 8016 Fucosidosis EB 0,5-1 (English Springer Spaniel) ml/ SW

28 Parauga Iedzimtās slimības SUŅIEM (turpin.) noņemšana 8007 Globoid Cell Leucodystrophy / Krabbe-disease EB 0,5-1 ml/ SW (West Highland White Terrier, Cairn Terrier) Glycogen Storage Disease Type II (GSDII, Pompe) (Finnish EB 0,5-1 8513 Lapphund, Lapponian Herder, ) ml/ SW 8156 Glycogen Storage Disease (GSDIIIa) EB 0,5-1 (Curly Coated Retriever) ml/ SW 8066 GM1-Gangliosidosis EB 0,5-1 (, Portuguese Waterdog, ) ml/ SW 8098 Grey Collie Syndrome (Canine Cyclic Neutropenia) EB 0,5-1 (Collie) ml/ SW 8068 GRMD (Muscular Dystrophy) EB 0,5-1 (Golden Retriever, Cavalier King Charles Spaniel) ml/ SW 8232 Hemophilia A (Factor VIII deficiency) EB 0,5-1 (Bichon Havanese) ml/ SW 8221 Hemophilia B (Factor IX deficiency) EB 0,5-1 (Rhodesian Ridgeback) ml/ SW 8449 Hereditary Ataxia (HA) EB 0,5-1 (Gordon Setter, Old English Sheepdog) ml/ SW 8179 Hereditary Neuropathy EB 0,5-1 (Greyhound) ml/ SW 8157 Hereditary Cataract (HSF4) EB 0,5-1 (Australian Shepherd, Wäller) ml/ SW 8576 Hereditary Cataract (HSF4)* EB 0,5-1 (Boston Terrier, French Bulldog, Staffordshire Bull Terrier) ml/ SW 8421 Hereditary nasal parakeratosis (HNPK)* EB 0,5-1 (Labrador Retriever) ml/ SW 8154 Hyperuricemia (SLC) EB 0,5-1 (All breeds) ml/ SW 8443 Hypomyelination - (SPS) EB 0,5-1 (Weimaraner) ml/ SW 8481 Ichthyose* EB 0,5-1 (Golden Retriever) ml/ SW 8474 Imerslund-Gräsbeck syndrome (IGS) EB 0,5-1 (Beagle) ml/ SW 8475 Imerslund-Gräsbeck syndrome (IGS) EB 0,5-1 () ml/ SW 8198 Junctional Epidermolysis Bullosa (JEB) EB 0,5-1 (German Shorthaired Pointer) ml/ SW 8459 Juvenile Epilepsy EB 0,5-1 (Lagotto Romagnolo) ml/ SW 8271 Juvenile laryngeal paralysis & polyneuropathy (JLPP) (Black EB 0,5-1 Russian Terrier, Rottweiler) ml/ SW

29 Parauga Iedzimtās slimības SUŅIEM (turpin.) noņemšana 8125 L-2-Hydroxyglutaric Aciduria (L-2-HGA) EB 0,5-1 (Staffordshire Bull Terrier) ml/ SW 8270 Lagotto Storage Disease (LSD) EB 0,5-1 (Lagotto Romagnolo) ml/ SW 8493 Late Onset Ataxia (LOA) (Jack Russell Terrier, Parson Russell EB 0,5-1 Terrier) ml/ SW 8487 Leonberger Polyneuropathy (LPN1) EB 0,5-1 (Leonberger) ml/ SW 8062 Malignant Hyperthermia (MH) EB 0,5-1 (All breeds) ml/ SW 8032 MDR1 Gene Defect* (Ivermectin Sensitivity) (Collie, Shetland Sheepdog, Australian Shepherd, Bobtail, Longhaired EB 0,5-1 Whippet, Silken ml/ SW Windhound, American , Waeller, Mc Nab, German Shepherd, Elo) 8069 Mucopolysaccharidosis Type VII (MPS) EB 0,5-1 (German Shepherd) ml/ SW 8273 Muscular dystrophy in Landseer (MDL) EB 0,5-1 (Landseer) ml/ SW 8411 Musladin-Lueke Syndrome (MLS) EB 0,5-1 (Beagle) ml/ SW 8220 Myostation mutation EB 0,5-1 ("Bully"-Whippet) ml/ SW 8022 Myotonia Congenita EB 0,5-1 (Miniature Schnauzer) ml/ SW 8067 Narcolepsy EB 0,5-1 (Doberman Pinscher, Labrador Retriever) ml/ SW 8429 Necrotizing Meningoencephalitis (PDE) EB 0,5-1 (Pug) ml/ SW 8457 Neonatal cerebellar abiotrophy (NCCD) EB 0,5-1 (Beagle) ml/ SW 8155 Neonatal Encephalopathy EB 0,5-1 (Standard Poodle) ml/ SW 8075 Neuronal Ceroid Lipofuscinosis (NCL) EB 0,5-1 (Border Collie, American Bulldog, Tibet Terrier) ml/ SW 8215 Osteogenesis imperfecta EB 0,5-1 (Dachshund) ml/ SW 8462 Persistent Müllerian Duct Syndrome (PMDS) EB 0,5-1 (Miniature Schnauzer) ml/ SW 8017 Phosphofructokinase Deficiency (PFKD) EB 0,5-1 (English Springer Spaniel, American Cocker Spaniel, Whippet, Wachtelhund ) ml/ SW

30 Parauga Iedzimtās slimības SUŅIEM (turpin.) noņemšana 8476 Polycystic Kidney Disease (PKD) EB 0,5-1 (Bull Terrier) ml/ SW 8483 Primary Ciliary Dyskinesia (PCD) EB 0,5-1 (Bobtail) ml/ SW 8226 Primary Lens Luxation (PLL) (, American Hairless Terrier, Chinese Crested, Chinese Foo Dog, Jagd Terrier, Jack Russell Terrier, Lakeland Terrier, Lancashire EB 0,5-1 Heeler, Lucas Terrier, Miniature Bull Terrier, Parson Russell Terrier, ml/ SW Patterdale Terrier, Rat Terrier, Sealyham Terrier, Tibet Terrier, Toy Fox Terrier, , Welsh Terrier) 8452 Primary Open Angle Glaucoma (POAG) EB 0,5-1 (Beagle) ml/ SW 8492 Protein Losing Nephropathy (PLN) EB 0,5-1 (Soft-Coated Wheaten Terrier ) ml/ SW Progressive Retinal Atrophy 8574 Bas PRA1 EB 0,5-1 (Basenji) ml/ SW 8135 crd- PRA EB 0,5-1 (Standard Wirehaired Dachshund) ml/ SW 8042 Dominant Form of PRA EB 0,5-1 (Bull Mastiff, English Mastiff) ml/ SW 8451 Generalized PRA EB 0,5-1 () ml/ SW 8200 GR_PRA1 EB 0,5-1 (Golden Retriever) ml/ SW 8520 GR_PRA2 EB 0,5-1 (Golden Retriever) ml/ SW 8573 pap_PRA1 EB 0,5-1 (Papillon, Phalène) ml/ SW 8094 prcd-PRA performed by Optigen* (American Cocker Spaniel, American Eskimo Dog, , Australian Shepherd, Australian Stumpy Tail Cattle Dog, Chesapeake Bay Retriever, Chinese Crested, Entlebucher Mountaindog, , EB 0,5-1 Golden Retriever, Kuvasz, Lapponian Herder, Labrador Retriever, ml/ SW Labradoodle, Nova Scotia Duck Tolling Retriever, Portuguese Waterdog, English Cocker Spaniel, Swedish Lapphund, Toy Poodle, Dwarf Poodle, , , Silky Terrier, Yorkshire Terrier, Markiesje)

31 8127 prcd-PRA performed by partnerlab* (American Cocker Spaniel, American Eskimo Dog, Australian Cattle Dog, Australian Shepherd, Australian Stumpy Tail Cattle Dog, Chesapeake Bay Retriever, Chinese Crested, Entlebucher Mountaindog, Finnish Lapphund, EB 0,5-1 Golden Retriever, Kuvasz, Lapponian Herder, Labrador Retriever, ml/ SW Labradoodle, Nova Scotia Duck Tolling Retriever, Portuguese Waterdog, English Cocker Spaniel, Swedish Lapphund, Toy Poodle, Dwarf Poodle, Norwegian Elkhound, Spanish Water Dog, Silky Terrier, Yorkshire Terrier, Markiesje)

8042 rcd 1- PRA EB 0,5-1 (Irish Setter, Irish Red and White Setter) ml/ SW 8042 rcd 1a-PRA EB 0,5-1 (Sloughi) ml/ SW 8153 rcd 2-PRA* Optigen EB 0,5-1 (Collie)* ml/ SW 8042 rcd 3-PRA EB 0,5-1 (Chinese Crested, ) ml/ SW 8435 rcd 4-PRA (Australian Cattle Dog, English Setter, Gordon Setter, Irish Setter, Irish EB 0,5-1 Red & White Setter, Polski Owczarek Nizinny, Small Münsterländre, ml/ SW Tibet Terrier) 8375 Shet_PRA EB 0,5-1 (Shetland Sheepdog) ml/ SW 8444 Type A-PRA Optigen EB 0,5-1 (Miniature Schnauzer) ml/ SW 8445 XL-PRA* Optigen EB 0,5-1 (Samoyed, Sibirian Husky) ml/ SW

8104 Pyruvat Dehydrogenase Phosphatase 1 Deficiency (PDP1) EB 0,5-1 (Clumber, Sussex-Spaniel) ml/ SW

8015 Pyruvatkinase Deficiency (PK Deficiency) EB 0,5-1 (Basenji, Westhighland White Terrier) ml/ SW 8150 Retinal Dysplasia* (OSD) EB 0,5-1 (Labrador Retriever, Samoyed) ml/ SW 8537 Spinocerebellar Ataxia* (SCA) EB 0,5-1 (Jack Russell Terrier, Parson Russell Terrier ) ml/ SW 8191 Startle Disease EB 0,5-1 (Irish Wolfhound) ml/ SW 8486 Thrombopathia EB 0,5-1 (Basset Hound, Landseer) ml/ SW 8143 Trapped Neutrophil Syndrome (TNS) EB 0,5-1 (Border Collie) ml/ SW

32 8210 von-Willebrand-Disease (vWD3) EB 0,5-1 (Dutch Kooiker) ml/ SW 8119 von-Willebrand Disease Type 1 (vWD1) (Doberman, German Pinscher, Manchester Terrier, Bernese Mountain Dog, EB 0,5-1 Coton de Tulear, Drentsche Patrijschond, Kerry Blue Terrier, Papillon, ml/ SW Stabyhound, , Poodle, Labradoodle)

8014 von-Willebrand Disease Type 2 (vWD2) EB 0,5-1 (German Wirehaired Pointer, German Shorthaired Pointer) ml/ SW 8233 von-Willebrand Disease Type 3 EB 0,5-1 (Scotch Terrier, Sheltie) ml/ SW 8063 X-SCID EB 0,5-1 (Basset, Welsh Corgi) ml/ SW

Testu kombinācijas 8570 Combi Parson Russell Terrier small EB 0,5-1 (Late onset Ataxia (LOA), Spinocerebellar Ataxia* (SCA) ml/ SW 8571 Combi Parson Russell Terrier large EB 0,5-1 (Late onset Ataxia (LOA), Spinocerebellar Ataxia* (SCA), Primary Lens ml/ SW Luxation (PLL) 8590 Combi Lagotto Romagnolo EB 0,5-1 Juvenile Epilepsy, Furnishing ml/ SW 8407 Combi Cavalier King Charles Spaniel EB 0,5-1 Dry Eye Curly Coat Syndrome, Episodic Falling ml/ SW 8277 PRA-package Golden Retriever EB 0,5-1 prcd-PRA*, GR_PRA1 and GR_PRA2 ml/ SW

Parauga Apmatojuma krāsa / garums SUŅIEM noņemšana 8144 EB 0,5-1 A-Locus (Agouti) ml/ SW 8023 B-Locus (Coat Colour Brown) e.g. Australian Shepherd, Border Collie, Cardigan W elsh Corgi, ACS, ECS, ESS, Dachshund, Dalmatien, Doberman Pinscher, Labrador- EB 0,5-1 Flatcoated Retriever, French Bulldog, Galgo Español, German ml/ SW Wirehaired Pointer, Newfoundland, Poodle, further breeds upon request 8196 EB 0,5-1 Curly ml/ SW 8136 EB 0,5-1 D-Locus (Dilution) ml/ SW

33 8018 E-Locus (Coat Colours Yellow, Lemon, Red, Cream, 38,50 Apricot) (ACS, Australian Shepherd, Beagle, Border Collie, Cardigan W EB 0,5-1 elsh Corgi, Dachshund, , Doberman Pinscher, German ml/ SW Shepherd, German Shorthaired Pointer, German W irehaired Pointer, ECS, ESS, Flatcoated-, Labrador Retriever)

8180 EH-Locus (sable) EB 0,5-1 Cocker Spaniel ml/ SW 8458 EG-Locus domino/grizzle EB 0,5-1 (Saluki, Afghan Hound) ml/ SW 8146 EM-Locus (Melanistic Mask Allele) (Afghan, Boxer, Bull Mastiff, Cairn Terrier, Cardigan Welsh Corgi, EB 0,5-1 English Bulldog, German Shepherd, Great Dane, Greyhound, Saluki, ml/ SW Staffordshire Bull Terrier, Whippet) 8195 EB 0,5-1 Furnishing ml/ SW 8188 EB 0,5-1 Merle-factor* ml/ SW 8124 EB 0,5-1 Coat Length (Longhaire/shorthaire) ml/ SW 8599 Hairlessness EB 0,5-1 (Chinese Crested Dog, Mexican Hairless Dog, Peruvian Hairless Dog) ml/ SW

8254 Harlequin EB 0,5-1 (Great Dane) ml/ SW 8405 Improper Coat - PCR EB 0,5-1 (Portuguese Waterdog) ml/ SW 8145 EB 0,5-1 K-Locus ml/ SW 8438 S-Locus EB 0,5-1 white spotting in dogs ml/ SW

Parauga DNS profils / vecāku noteikšana SUŅIEM noņemšana 8109 EB 0,5-1 Parentage verification ml/ SW 8107 DNA-Profile (each parent) EB 0,5-1 (Identity confirmation) ml/ SW 8212 likelihood ratio calculation (incl. DNA-Profile) EB 0,5-1 (Breeds upon request) ml/ SW 8211 Breed Analysis (DNA-Profile + assignment) EB 0,5-1 (Breeds upon request) ml/ SW

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