Cotard's Syndrome: Two Cases of Self-Starvation
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Caso Clínico / Case Report open-access Cotard’s Syndrome: Two Cases of Self-Starvation Síndrome de Cotard: Dois Casos de Recusa Alimentar Bruno Gonçalves Teixeira*, Ana Filipa Araújo*, João Ferreira Perestrelo* RESUMO Palavras-Chave: Síndrome de Cotard; De- Introdução: A Síndrome de Cotard é uma pressão; Delírio Niilista. condição clínica relativamente rara que se ca- racteriza por vários graus de delírios niilistas, ABSTRACT quase sempre na forma de auto-negação. Background: Cotard´s syndrome is a rela- tively rare condition characterized by vari- Objectivos: Descrever dois casos de Síndrome ous degrees of nihilist delusions, often in the de Cotard associados a recusa alimentar e rea- form of self-negation. lizar uma revisão do conceito e das caracterís- ticas clínicas desta síndrome. Aims: To report two cases of Cotard’s syn- drome associated with self-starvation and to Métodos: Realizou-se a recolha de informa- review the concept and clinical features of ção de dois casos clínicos associados a recu- the condition. sa alimentar. Procedeu-se a uma revisão do conceito e das características clínicas que lhe Methods: Two clinical cases of the syndrome estão associadas. were obtained and a literature review of the theme was shortly surveyed. Resultados e Conclusões: O primeiro caso versa sobre uma mulher que acreditava que Results and Conclusions: The first case is o seu esófago e estômago estariam colados. about a woman who believed that her eso- Foi medicada com sertralina, mirtazapina e phagus and stomach were glued. She was risperidona, com bons resultados. O segun- treated with sertraline, mirtazapine and ris- do caso descreve um homem que acreditava peridone with good results. The second case que a sua garganta fora queimada e que não describes a man who believed his throat was possuía nenhum órgão interno. Foi medicado burnt and he had no internal organs. He com clomipramina e risperidona, mostrando was treated with clomipramine and risperi- grande melhoria. Esta síndrome é uma enti- done showing great improvement. dade nosológica e clínica que não deve ser es- This syndrome is a nosological and clinical quecida. É essencial fornecer uma abordagem entity that should not be forgotten. It is es- terapêutica urgente e adequada em pacientes com esta síndrome. * Serviço de Psiquiatria e Saúde Mental do Centro Hospitalar de Vila Nova de Gaia/Espinho [email protected] Recebido / Received: 29/12/2014 • Aceite / Accepted: 10/08/2015 Revista do Serviço de Psiquiatria do Hospital Prof. Doutor Fernando Fonseca, EPE www.psilogos.com 124 Junho 2015 • Vol. 13 • N.º 1 Cotard’s Syndrome: Two Cases of Self-Starvation PsiLogos • pp 124-133 sential to provide an urgent and adequate the belief that they had in fact died revealed therapeutic approach to these patients. a consistent combination of additional symp- toms including depressed mood, abnormal Key-Words: Cotard Syndrome; Depression; feelings, depersonalization and derealization, Nihilistic Delusion. and evidence of face-processing impairments. More exotic concurrent symptoms have been INTRODUCTION reported elsewhere, including hydrophobia6 Few pathologies of the self are as profound and and lycanthropy2,7. striking as those reported in cases of Cotard’s During the 20th century, it continued to attract syndrome, which can involve the belief that the attention of diagnostic phenomenologists. one is dead. The assertions of some patients Currently, many investigators of the condition with this delusion come close to violating the conceptualize it as at least a component of a famous Cartesian dictum “cogito ergo sum”. mental disorder, frequently a major depressive Descartes explored the limits of radical skep- disorder4. However, the issue of whether the ticism and concluded that whereas one could Cotard’s phenomenon constitutes a unique certainly doubt the evidence of one’s senses, it mental disorder, a discrete syndrome (asso- was not possible to doubt one’s existence. Yet ciated with a range of conditions such as de- some Cotard patients maintain that they are pression, psychosis, organic conditions and so dead or that they do not exist1,2. on), or merely a psychiatric symptom remains The classic reports of this condition were pub- unanswered1,2. lished by the neurologist Jules Cotard3, who Berrios and Luque, in an extensive review of described a clinical state that he termed délire the conceptual history of Cotard’s syndrome, des négations. The French eponym délire de concluded that Jules Cotard probably viewed it Cotard was later adopted and translated into as a subtype of melancholia (anxious melan- English as Cotard’s syndrome4. Although this cholia)5. In as attempt to further understand later designation is often identified with the the phenomenology of the condition, Berrios belief that one is dead, it must be underlined and Luque, using an exploratory factor analy- that the condition is a syndrome and not a sis of 100 cases of Cotard’s syndrome reported symptom as it is often incorrectly conveyed in literature, extracted three factors: psychotic in literature. Cotard himself did not regard depression, Cotard type I and Cotard type II4. that belief as an essential defining feature The psychotic depression patients mostly had of the condition he described1,5. Young and depression and few nihilistic delusions. Cotard Leafhead’s analysis of Cotard’s cases revealed type I patients on the other hand, had only the a series of commonly occurring features and nihilistic delusions (pure Cotard’s syndrome) symptoms, including self-deprecatory delu- and few depressive symptoms, whereas Co- sions, suicidal ideation, feelings of guilt, and tard type II patients were a mixed group with denial of body parts. Young and Leafhead’s depression, anxiety and auditory hallucina- subsequent comparison of three patients with tions10. Revista do Serviço de Psiquiatria do Hospital Prof. Doutor Fernando Fonseca, EPE www.psilogos.com 125 Junho 2015 • Vol. 13 • N.º 1 Bruno Gonçalves Teixeira, Ana Filipa Araújo, João Ferreira Perestrelo PsiLogos • pp 124-133 In the same study, Berrios and Luque diag- the earlier classification of the syndrome by nosed depression in 89% of the 100 cases. The Berrios and Luque as follows: the germina- most frequent nihilistic delusions were related tion stage corresponds to psychotic depression, to the body (86%) and with existence (69%). the blooming stage to Cotard type II and the Anxiety (65%) and guilt (63%) were common, chronic stage to Cotard type I10. followed by hypochondriacal delusions (58%) The current diagnostic classifications (DSM-5 and immortality delusions (55%)11. and CID-10) exclude Cotard’s syndrome, con- There are several proposed mechanisms for firming the trend to reject it as a nosological Cotard’s syndrome. It may begin with anom- and clinical entity14. alous perceptual experiences or their discon- The aims of this article are to describe the clin- nection from emotional or limbic processes, ical presentation and the management of two and there may be a failure in belief evaluation cases of Cotard´s syndrome and to review the or a tendency to negative self-attribution2,8,9,12. concept and clinical features of the condition. Many patients have psychiatric disease with psychotic depression, an internalized attribu- CASE STUDY 1 tional style, or associated depersonalization2. The first case we report is about a 66-year-old It is worth emphasizing that the syndrome is woman that will be addressed as Mrs. H. best conceptualized as being on a spectrum Mrs. H. had no psychiatric background up un- (complete/incomplete): the complete form in til April 2012, when she was admitted to our which nihilistic delusions are clearly present department after developing a clinical picture and the incomplete forms which are often of depressed mood and progressive onset of de- combinations of depressed mood, delusions lusions of ruin, ill health, guilt and self-star- of guilt and hypochondriasis, and hallucina- vation. The patient started experiencing these tions. Also the nihilistic delusion itself could symptoms after her husband’s unexpected vary in its degree of severity – from severe death, approximately six months prior to ad- (patient denies his own and the world’s exist- mission. ence) to mild (patient feels that he is loosing Mrs. H. had a medical history of hysterectomy, his reasoning and feelings). Yamada et al.13 cholecystectomy and appendectomy. There attempted to trace the onset and longitudinal was no history of substance misuse and she progression of the condition from a phenom- was taking no medication when admitted to enological perspective and identified three our inward. distinct stages: the germination stage (prodro- Mrs. H. lived in Gaia for years in a symbiot- mal period associated with depression and hy- ic relationship with her husband. Their sons pochondriacal symptoms), the blooming stage were living in far distant cities, so they would (full blown development of the syndrome with only be present occasionally supporting their delusions of negation) and the chronic stage parents the way they could. After her hus- (chronic depressive type or chronic delusional band’s sudden death, Mrs. H. couldn’t face his type). They equated the above three stages to absence and the solitude. She started feeling Revista do Serviço de Psiquiatria do Hospital Prof. Doutor Fernando Fonseca, EPE www.psilogos.com 126 Junho 2015 • Vol. 13 • N.º 1 Cotard’s Syndrome: Two Cases of Self-Starvation PsiLogos • pp 124-133 depressed, describing insomnia, anorexia and tinued refusing to ingest any solid food, her intense anguish. A month later she developed daughter took her to a psychiatric emergency delusions of ruin, believing her pension wasn’t where she was transferred to our unit. enough to ensure her subsistence and alleging As she was admitted to our department, she her refrigerator wasn’t working well because looked very thin (she had lost 42 pounds in the the food had a bad taste and was constantly meanwhile and her BMI was 14 by the time).