Bionic Eye.Pdf

Total Page:16

File Type:pdf, Size:1020Kb

Bionic Eye.Pdf DEPARTMENT OF COMPUTERSCIENCE PRESENTATION ON BIONIC EYE P RESENTED BY CH.LALITHA P.L.MADHURI [email protected] [email protected] ABSTRACT diseased cells in the retina and stimulates the remaining viable cells. This is a revolutionary Here, we present a description of a block piece of technology and really has the scheme, specific features of design and results potential to change people's lives. But we need of testing for a prototype of a bionic eye, types to be aware it is still some way in the future. of them and its applications. The bionic eye is intended to provide vision, partially to the INTRODUCTION visually impaired by use of the modern day A visual prosthesis or bionic eye is a form electronics devices like CCD cameras. The of neural prosthesis intended to partially comprises a computer chip that sits in the back restore lost vision or amplify existing vision. of the individual's eye, linked up to a mini It usually takes the form of an externally- video camera built into glasses that they wear. worn camera that is attached to a stimulator Images captured by the camera are beamed to on the retina, optic nerve, or in the visual the chip, which translates them into impulses cortex, in order to produce perceptions in the that the brain can interpret. Although the visual cortex. images produced by the artificial eye were far from perfect, they could be clear enough to These experimental visual devices are allow someone who is otherwise blind to modeled on the cochlear implant or bionic recognize faces. The paper discusses the ear devices, a type of neural prosthesis in differences working methodologies used in use since the mid 1980s. These are an each of them. During the tests and the clinical externally-worn microphone and processor trails, this device made six blind people to that is attached to a stimulator in the regain their vision partially. The potential cochlea, auditory nerve, in order to produce advantage of using bionic eye is to be able to sound perception in the auditory cortex. remove the blindness completely by making the advances in the present research and Scientific research since at least the 1950s improving manufacturing technologies. This has investigated interfacing electronics at break through is likely to benefit the level of the retina, optic nerve, thalamus, approximately one crore world population and cortex. Visual prosthetics, which have who suffer from the most common causes of been implanted in patients around the world blindness, Retinitis Pigmentosa, Macular both acutely and chronically, have Degeneration. The implant bypasses the demonstrated proof of principle, but do not yet offer the visual acuity of a normally the help of electronic devices that assist this sighted eye cells in performing the task of vision, we can make these lakhs of people get back their The ability to give sight to a blind person via vision at least partially. A design of an a bionic eye depends on the circumstances optoelectronic retinal prosthesis system that surrounding the loss of sight. For retinal can stimulate the retina with resolution prostheses, which are the most prevalent corresponding to a visual acuity of 20/80— visual prosthetic under development (due to sharp enough to orient yourself toward ease of access to the retina among other objects, recognize faces, read large fonts, considerations), vision loss due to watch TV and, perhaps most important, lead degeneration of photoreceptors (retinitis an independent life. The researchers hope their pigmentosa, choroideremia, geographic device may someday bring artificial vision to atrophy macular degeneration) is the best those blind due to retinal degeneration. candidate for treatment. Candidates for visual prosthetic implants find the procedure ACTUAL EYE SYSTEM most successful if the optic nerve was developed prior to the onset of blindness. Our ability to see is the result of a process Persons born with blindness may lack a fully similar to that of a camera. In a camera, light developed optical nerve, which typically passes through a series of lenses that focus develops prior to birth. images onto film or an imaging chip. The eye performs a similar function in that light Visual prosthetics are being developed as a passes through the cornea and crystalline potentially valuable aide for individuals with lens, which together focus images onto the visual degradation. The visual prosthetic in retina—the layer of light sensing cells that humans remains investigational. lines the back of the eye. Once stimulated by light, the cells within Need for the BIONIC EYE: the retina process the images by converting It has been shown that electric stimulation of their analog light signals into digital electro- retinal neurons can produce perception of light chemical pulses that are sent via the optic in patients suffering from retinal degeneration. Using this property the eye and make uses of nerve to the brain. A disruption or the functional cells to retain the vision with malfunction of any of these processes can With an artificial retina device, a miniature result in loss of vision. camera mounted in eyeglasses captures images and wirelessly sends the information to a microprocessor (worn on a belt) that converts the data to an electronic signal and transmits it to a receiver on the eye. The receiver sends the signals through a tiny, thin cable to the microelectrode array, stimulating it to emit pulses. The artificial retina device thus bypasses defunct photoreceptor cells and transmits electrical How an Artificial Retina Works signals directly to the retinas remaining viable cells. The pulses travel to the optic Normal vision begins when light enters and nerve and, ultimately, to the brain, which moves through the eye to strike specialized perceives patterns of light and dark spots photoreceptor (light-receiving) cells in the corresponding to the electrodes stimulated. retina called rods and cones. These cells Patients learn to interpret these visual convert light signals to electric impulses that patterns. are sent to the optic nerve and the brain. Retinal diseases like age-related macular The U.S. Department of Energy Artificial degeneration and retinitis pigmentosa Retina Project is funding an effort to destroy vision by annihilating these cells. develop an implantable microelectronic retinal device that restores reading ability, facial recognition, and unaided mobility in people with retinitis pigmentosa and age- related macular degeneration. Developed with funding from this program, the Argus II retinal implant from Second Sight is currently undergoing clinical testing in Europe. The Bionic Eye System When the pulses reach the retinal implant, they excite the electrode array. The array The entire system runs on a battery pack acts as the artificial equivalent of the retina's that's housed with the video processing unit. photoreceptors. The electrodes are When the camera captures an image -- of, stimulated in accordance with the encoded say, a tree -- the image is in the form of light pattern of light and dark that represents the and dark pixels. It sends this image to the tree, as the retina's photoreceptors would be video processor, which converts the tree- if they were working (except that the pattern shaped pattern of pixels into a series of wouldn't be digitally encoded). The electrical pulses that represent "light" and electrical signals generated by the stimulated "dark." The processor sends these pulses to a electrodes then travel as neural signals to the radio transmitter on the glasses, which then visual center of the brain by way of the transmits the pulses in radio form to a normal pathways used by healthy eyes -- the receiver implanted underneath the subject's optic nerves. In macular degeneration and skin. The receiver is directly connected via a retinitis pigmentosa, the optical neural wire to the electrode array implanted at the pathways aren't damaged. The brain, in turn, back of the eye, and it sends the pulses down interprets these signals as a tree and tells the the wire. subject, "You're seeing a tree." It takes some training for subjects to actually see a tree. At first, they see mostly light and dark spots. But after a while, they learn to interpret what the brain is showing them, and they eventually perceive that pattern of light and dark as a tree. The first version of the system had 16 electrodes on the implant and is still in A magnified image of an eye with clinical trials at the University of California age-related in Los Angeles. Doctors implanted the macular degeneration retinal chip in six subjects, all of whom regained some degree of sight. They are now able to perceive shapes (such as the shaded computer chips and contains approximately outline of a tree) and detect movement to 5,000 microscopic solar cells called varying degrees. The newest version of the “microphotodiodes,” each with its own system should offer greater image resolution stimulating electrode. because it has far more electrodes. If the In retinas with retinal degeneration, these upcoming clinical trials, in which doctors micro photodiodes convert light energy will implant the second-generation device contained in images into electrochemical into 75 subjects, are successful, the retinal impulses that stimulate the remaining retinal prosthesis could be commercially available cells. The ASR microchip is self-contained, by 2010. The estimated cost is $30,000. powered solely by incident light and does Researchers are already planning a third not require the use of external wires, version that has a thousand electrodes on the batteries, headsets or ancillary computers. retinal implant, which they believe could When surgically implanted under the allow for facial-recognition capabilities retina—in a location known as “sub retinal space”—the ASR chip is designed to ASR Device produce visual signals similar to those produced by the photoreceptor layer.
Recommended publications
  • Energetic Medicine for Retinitis Pigmentosa
    Energetic medicine for Retinitis Pigmentosa Retinitis Pigmentosa Classification and external resources Fundus of patient with retinitis pigmentosa, mid stage (Bone spicule- shaped pigment deposits are present in the mid periphery along with retinal atrophy, while the macula is preserved although with a peripheral ring of depigmentation. Retinal vessels are attenuated.) From a review by Christian Hamel, 2006. ICD-10 H35.5 ICD-9 362.74 OMIM 268000 MedlinePlus 001029 MeSH D012174 Retinitis Pigmentosa Overview GeneReviews Author - Editor: Professor of Medicine Desire’ Dubounet, D. Sc. L.P.C.C Retinitis pigmentosa (RP) is an inherited, degenerative eye disease that causes severe vision impairment and often blindness.[1] The progress of RP is not consistent. Some people will exhibit symptoms from infancy, others may not notice symptoms until later in life.[2] Generally, the later the onset, the more rapid is the deterioration in sight.[citation needed] Those who do not have RP have 90 degree peripheral vision, while some people who have RP have less than 90 degrees. A form of retinal dystrophy, RP is caused by abnormalities of the photoreceptors (rods and cones) or the retinal pigment epithelium (RPE) of the retina leading to progressive sight loss. Affected individuals may experience defective light to dark, dark to light adaptation or nyctalopia (night blindness), as the result of the degeneration of the peripheral visual field (known as tunnel vision). Sometimes, central vision is lost first causing the person to look sidelong at objects. The effect of RP is best illustrated by comparison to a television or computer screen. The pixels of light that form the image on the screen equate to the millions of light receptors on the retina of the eye.
    [Show full text]
  • Image Analysis for Automatically-Driven Bionic Eye
    1 Image Analysis for Automatically-Driven Bionic Eye F. Robert-Inacio1,2, E. Kussener1,2, G. Oudinet2 and G. Durandau2 1Institut Materiaux Microelectronique et Nanosciences de Provence, (IM2NP, UMR 6242) 2Institut Superieur de l’Electronique et du Numerique (ISEN-Toulon) France 1. Introduction In many fields such as health or robotics industry, reproducing the human visual system (HVS) behavior is a widely sought aim. Actually a system able to reproduce even partially the HVS could be very helpful, on the one hand, for people with vision diseases, and, on the other hand, for autonomous robots. Historically, the earliest reports of artificially induced phosphenes were associated with direct cortical stimulation Tong (2003). Since then devices have been developed that target ùany different sites along the visual pathway Troyk (2003).These devices can be categorized according to the site of action along the visual pathway into cortical, sub-cortical, optic nerve ane retinal prostheses. Although the earliest reports involved cortical stimulation, with the advancements in surgical techniques and bioengineering, the retinal prosthesis or artificial retina has become the most advanced visual prosthesis Wyatt (2011). In this chapter, both applications will be presented after the theoretical context, the state of the art and motivations. Furthermore, a full system will be described including a servo-motorized camera (acquisition), specific image processing software and artificial intelligence software for exploration of complex scenes. This chapter also deals with image analysis and interpretation. 1.1 Human visual sytem The human visual system is made of different parts: eyes, nerves and brain. In a coarse way, eyes achieve image acquisition, nerves data transmission and brain data processing (Fig.
    [Show full text]
  • Capsulotomy Does Make a Difference,” Slightly Less Variability in the Manual Group at 6 More Patients Were Within 0.25 D Said Dr
    CLINICAL NEWS & ANALYSIS SPECIAL REPORT // RETINA VMA ADVANCES : WET AMD 'BEST RESPONDERS' March 1, 2013 In This Issue VOL. 38, NO. 5 EDITORIAL 4 Truth be told for Why honesty in the physician-patient Hope patients relationship is not what it seems GLAUCOMA 12 The next step with late-stage RP in drug delivery How a topical micro-droplet system targets direct application to the ocular surface FDA APPROVAL GENERAL 32 Innovation abounds at OIS Regulatory and investment climate What fosters drug, device opportunities The retinal prosthesis is designed to FOLLOW US ONLINE: bypass the eye structure damaged OphthalmologyTimes.com by RP with electrical stimulation of the retina to induce Refractive visual perception in CAPSULOTOMY blind individuals. When DOES MAKE A Commercial launch planned for later DIFFERENCE this year By Lynda Charters (Photo courtesy of Second Sight) SALT LAKE CITY :: FEMTOSECOND LASER capsulotomies provide sig- nificantly more predictable effec- Sight Medical Products to market its tive lens positions compared with FDA approval of retinal prosthesis retinal prosthesis (Argus II Retinal manual procedures. Prosthesis System) for patients with Robert J. Cionni, MD, discussed the brings limited sight to individuals late-stage RP. The system is the first superiority of the femtosecond laser for and only retinal prosthesis commer- creating capsulotomies compared with with retinitis pigmentosa cially available anywhere in the world. the conventional manual method and The regulatory agency’s decision re-optimization of lens constants for By Cheryl Guttman Krader comes after the 19 members of the FDA Ophthal- accurate laser refractive lens surgery. Reviewed by Mark S. Humayun, MD, PhD mic Devices Advisory Panel voted unanimously “The capsulotomy does make a dif- in September 2012 to recommend approval.
    [Show full text]
  • Advanced Topics in Neurological Disorders
    DR.RUPNATHJI( DR.RUPAK NATH ) ADVANCED TOPICS IN NEUROLOGICAL DISORDERS Edited by Ken-Shiung Chen Contents Preface IX Part 1 Bioengineering in Neurological Disorders 1 Chapter 1 Image Analysis for Automatically-Driven Bionic Eye 3 F. Robert-Inacio, E. Kussener, G. Oudinet and G. Durandau Chapter 2 Methods of Measurement and Evaluation of Eye, Head and Shoulders Position in Neurological Practice 25 Patrik Kutilek, Jiri Hozman, Rudolf Cerny and Jan Hejda Chapter 3 Mesenchymal Stromal Cells to Treat Brain Injury 45 Ciara C. Tate and Casey C. Case Chapter 4 Development of Foamy Virus Vectors for Gene Therapy for Neurological Disorders and Other Diseases 79 Yingying Zhang, Guoguo Zhu, Yu Huang, Xiaohua He and Wanhong Liu Chapter 5 Real-Time Analysis of Intracranial Pressure Waveform Morphology 99 Fabien Scalzo, Robert Hamilton and Xiao Hu Part 2 Proteomic Analysis in Neurological Disorders 127 DR.RUPNATHJI( DR.RUPAK NATH ) Chapter 6 Developing Novel Methods for Protein Analysis and Their Potential Implementation in Diagnosing Neurological Diseases 129 Olgica Trenchevska, Vasko Aleksovski, Dobrin Nedelkov and Kiro Stojanoski Chapter 7 Angelman Syndrome: Proteomics Analysis of an UBE3A Knockout Mouse and Its Implications 159 Low Hai Loon, Chi-Fung Jennifer Chen, Chi-Chen Kevin Chen, Tew Wai Loon, Hew Choy Sin and Ken-Shiung Chen VI Contents Part 3 Migraine and the Use of Herbal Medicine as an Alternative Treatment 185 Chapter 8 Migraine: Molecular Basis and Herbal Medicine 187 Mohammad Ansari, Kheirollah Rafiee, Solaleh Emamgholipour and Mohammad-Sadegh Fallah Part 4 Neuropsychiatry of Drug and Alcohol Dependence 215 Chapter 9 Substance Dependence as a Neurological Disorder 217 William Meil, David LaPorte and Peter Stewart DR.RUPNATHJI( DR.RUPAK NATH ) Part 1 Bioengineering in Neurological Disorders DR.RUPNATHJI( DR.RUPAK NATH ) DR.RUPNATHJI( DR.RUPAK NATH ) 1 Image Analysis for Automatically-Driven Bionic Eye F.
    [Show full text]
  • A Study on Customer Awarness Towards Bionic Eyes
    Vol-3 Issue-3 2017 IJARIIE-ISSN(O)-2395-4396 A STUDY ON CUSTOMER AWARNESS TOWARDS BIONIC EYES AUTHOR: ASH POULOSE STUDENT, M.COM (IB), DEPARTMENT OF COMMERCE, SRI KRISHNA ARTS AND SCIENCE COLLEGE, KUNIAMUTHUR, COIMBATORE-641008, TAMILNADU, INDIA ABSTRACT Bio technology has become the fastest-growing area of scientific research, with inventions of new devices. Technology has done wonders which help the mankind. Prosthetics use to help overcome handicaps. A training system called brain port is letting people with visual and balance disorders bypass their damaged sensory organs and instead send information to their brain through the tongue. Now, a company called second sight has received FDA approval to begin us. Trials of retinal implant system that gives blind people a degree of vision. A visual prosthesis, often referred to as a bionic eye, is an experimental visual device intended to restore functional vision in those suffering from partial or total blindness. A world renowned Portuguese doctor implanted a bionic eye in a person born blind. Many devices have been developed, usually modeled on the cochlear implant or bionic ear devices, a type of neural prosthesis in use since the mid-1980s. The idea of using electrical current (e.g., electrically stimulating the retina or the visual cortex) to provide sight dates back to the 18th century, discussed by Benjamin Franklin, Tiberius Cavalla and Charles Leroy. Keywords: Scientific Research, Overcome Handicaps, Visual Device, Electrical Current. INTRODUCTION OF THE STUDY INTRODUCTION It comprises a computer chip which is kept in the back of the individual’s eye, linked up using a mini video camera built into glasses that they wear.
    [Show full text]
  • Samsung Galaxy S8 Vs Galaxy S7: What's the Rumoured Difference?
    7 1 Brain-implanted 0 2 Hardware Could y r Be The Next Step a u r In Restoring Lost Sight b e F , 2 e u s Huawei Mate s I 9 Porsche Design . 9 . HTC Ocean Note l o V LG G6 Samsung Galaxy S8 Vs Galaxy S7: What's The Rumored Difference? Recession: Businesses Things To Consider Should How To When Giving Your Leverage Stop Car Child The First On Technology Battery For Operational Drains Smart phone Efficiency COVER NewsByte 4 13 NCC Calls For Digitization Of Economy Mobile Money 12 IMF Mobile Money Hopeful Digital Switch Over: On Mobile Money How Prepared Is Nigeria? NewsByte 30 Motoring Total Nigeria Plc Promotes On-Board-Computer 20 (OBC) Rules Global NewsByte 6 AMG Le43 2017 Worldwide IT Spending To Hit $3.5 Trillion Feature Article Product Review 27 32 Ten years of the iPhone Will Platforms Save Society: Product Review The Need For Inclusiveness 34 Samsung eHealth Galaxy S8 Vs Galaxy S7 31 Global NewsByte Brain-implanted Hardware 35 Could Be The Next Step In Government Should Prioritize Restoring Lost Sight Broadband - ITU Editor-in-Chief Ufuoma Emuophedaro Editor Let's Do Much With Our Little Chidiebere Nwankwo lot of things are happening in the economy. While the plan is for ICT to bail out the Nigerian economy, paradoxically, the economy seem to be Director of Operations Adepressing ICT, hampering its planned growth to a salvaging sector. In recent times, almost all the sub-sectors of the ICT industry, just like every other sector of the economy, have been lamenting on the effect of the Olalekan Akindele recession on the growth of their sub-sectors.
    [Show full text]
  • Retinal Prostheses: the Argus System
    Technology and Innovation, Vol. 19, pp. 605-611, 2018 ISSN 1949-8241 • E-ISSN 1949-825X Printed in the USA. All rights reserved. http://dx.doi.org/10.21300/19.3.2018.605 Copyright © 2018 National Academy of Inventors. www.technologyandinnovation.org RETINAL PROSTHESES: THE ARGUS SYSTEM Tai-Chi Lin1,2,3,4, Lan Yue1,2, and Mark S. Humayun1,2 1Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA 2USC Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, USA 3Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China 4Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China In the late 1990s, Humayun et al. demonstrated intraoperative retinal stimulations from a multi-electrode array in blind volunteers with little or no light perception. The participants reported electrically-elicited visual perception in the visual field that corresponded well to the retinotopic area of stimulation. The subjects exhibited ability to discriminate two separate stimulation sites and to track perception as the electrode moved across the retina. In another proof-of-concept trial, Rizzo et al. demonstrated reproducible visual perception with electrical stimulations of retina in retinitis pigmentosa (RP) patients. With these and other important pilot studies, two generations of the Argus epiretinal prostheses (Argus I and Argus II), which function by stimulating the remaining inner retinal neurons in patients with advanced retinal degeneration, were developed. The basic operations of the Argus series systems are similar, both consisting of a miniature camera, an external video processing unit, extraocular electron- ics, and an intraocular electrode array implant.
    [Show full text]
  • Curriculum Vitae
    CURRICULUM VITAE Personal Contact Information: Name in Full Mark S. Humayun, MD, PhD Business Address University of Southern California 1441 Eastlake Avenue MC 9175, NTT 4436 Los Angeles, CA 90033 Business Phone (323) 865-3092 Citizenship USA E-mail Address [email protected] [email protected] Education: High School Georgetown Preparatory, Rockville, MD 1980 College or University Georgetown University, BS 1984 Medical School Duke University Medical School, MD 1989 Graduate School University of North Carolina, PhD in Biomedical Engineering , 1994 Internship Roanoke Memorial Hospital, 1990 Residency Duke Eye Center, 1990-1993, Ophthalmology Fellowships Wilmer Ophthalmological Institute, 1994 Retinovascular Surgery Wilmer Ophthalmological Institute, 1994-1995 Vitreoretinal Surgery Licensure California, 1993 Florida, 1994 Board Certificate American Board of Ophthalmology, 1995 National Board of Medical Examiners (Diplomat) Professional Background: Academic University of Southern California Appointments • University Professor • Cornelius J. Pings Chair in Biomedical Sciences • Professor of Ophthalmology, Biomedical Engineering, Cell and Neurobiology 2001-Present • Interim Chair, Department of Ophthalmology 2013-2014 • Inaugural Co-Director, USC Eye Institute 2013-Present • Director, Institute of Biomedical Therapeutics 2013-Present • Director, USC Sensory Science Institute 2013-Present California Institute of Technology • Visiting Associate in Medical Engineering 2014-Present Johns Hopkins University • Associate Professor 2000-2001 • Assistant
    [Show full text]
  • 4 International Mechatronical Student
    Proceedings of 4th INTERNATIONAL MECHATRONICAL STUDENT micro-CONFERENCE December 20, Óbuda University, Donát Bánki Faculty of Mechanical and Safety Engineering, Budapest, In cooperation with: Institute of Mechatronics & Vehicle Engineering; Office of International Education Bánki HöK Proceedings of the 4th International Mechatronic Student micro-Conference, Budapest 2016. Eds.: A. Dineva, I. Nagy Disclaimer The papers published in these proceedings reflect the opinion of their respective authors. Information contained in the papers has been obtained by the editors from sources believed to be reliable. Text, figures, and technical data should have been carefully worked out. However, neither the publisher nor the editors/authors guarantee the accuracy or completeness of any information published herein, and neither the publisher nor the editors/authors shall be responsible for any errors, omissions, or damages arising out of this publication. Trademarks are used with no warranty of free usability. Proceedings of the 4th International Mechatronic Student micro-Conference, Budapest 2016. Eds.: A. Dineva, I. Nagy Copyright © Copyright 2016 Óbuda University, Donát Bánki Faculty of Mechanical & Safety Engineering, Institute of Mechatronics & Vehicle Engineering, Budapest, Hungary Proceedings of the 4th International Mechatronic Student micro-Conference, Budapest 2016. Eds.: A. Dineva, I. Nagy Proceedings of the 4th International Mechatronic Student micro-Conference, 2016 Editors: Adrienn Dineva, István Nagy Published by Óbuda University Press,
    [Show full text]