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Newsletter 08-04 Newsletter April 2008 Santa Clara Valley Section American Chemical Society Volume 30 No. 4 APRIL 2008 NEWSLETTER TOPICS April Dinner Meeting ® • Chair’s Message The Discovery and Development of LIPITOR Bruce Roth, Ph.D. • The Discovery and Development Come to concept of tissue selectivity of of LIPITOR April’s dinner HMGRIs and how the physicochemi- • April Dinner Meeting meeting and not cal properties of compounds in this only meet some class are related to safety and efficacy. • Family Science Night of our colleagues Biography • Local Science Fair Activities in the California Bruce Roth received his BS in Section, but join • Bylaws Election Results continued on next page us also for an • Registration Open for the Short interesting pres- Course Circuit entation given by Dr. Bruce D. Roth, Senior Director Chemistry, Genentech • Call for Nominations: Shirley B. April Small Molecule Discovery. Dr. Roth is Radding Award well known for his synthesis of the Dinner Meeting • New Legislative Action Network compound known as Lipitor as well Date: Wednesday, April 23, 2008 Homepage as his many other contributions to Time: 6:00 Social Hour science. 7:00 Dinner • Chemployment Abstracts The dinner meeting will be on 8:00 Presentation April 23rd, and held at the Genentech Location: Genentech Inc. campus in South San Francisco. Grandview Place/DNA Way Chair’s Message Directions, a campus map and details Building 33, Cafeteria Once again my time has gotten regarding building location, entrance South San Francisco, CA away from me, and this time I am into the building, and parking are Speaker: Dr. Bruce Roth really late. My apologies to everyone provided on the next page. Also at The Discovery and that works on the newsletter, for being the following web site: Development of LIPITOR so slow. Every rationale that I write www.gene.com/gene/contact/san- Cost: $25.00 Buffet Dinner looks like an excuse to me, and I can francisco.html Roasted Broccoli Salad w/Parmiggiano only imagine that it will look even Abstract Reggiano, Roasted Chicken w/Romesco worse to anyone else. The discovery and development Sauce, Panko Crusted Salmon with Lemon Pepper Sauce, Tiramisu for As we had no speaker or meeting of the potent HMG-CoA reductase dessert in March, I hope to see everyone at inhibitor Lipitor (atorvastatin calcium), the April meeting, on the 23rd, at the largest selling drug in the history Reservations: www.scvacs.org Genentech. This will be a joint meet- of the pharmaceutical industry, will be Shirley Radding 408-246-2564 ing with the California Section, and overviewed from its design and syn- 408-296-8625 Fax the speaker will be Dr. Bruce Roth, of thesis to clinical testing. A key part of Genentech. the understanding the success of Reservations must be made by April 18th stating your name, address, This year your local section Lipitor is related to the enhanced safe- company affiliation, and number of ty and efficacy of this agent in com- Annual Report was submitted to the people in party. If you are unable to parison to other HMG-CoA reductase National ACS office on time – is that honor your reservation and do not can- inhibitors (HMGRIs). This talk will good news or what? Please, hold your cel by Monday, April 21st, you will be excitement in check. A copy of the overview the structure activity rela- invoiced following the dinner meeting. report is posted on our web site, for tionship that led to the discovery of continued on next page atorvastatin calcium as well as the April Dinner Meeting, continued from front page Creative Invention, the 2003 Gustavus Chair’s Message, continued from front page Chemistry from St. Joseph’s College in J. Esselen Award for Chemistry in the those who wish to know more about Philadelphia, PA (1976). He then Public Interest, sponsored by the what the Santa Clara Valley section moved to Iowa State University where North East Region Section of the accomplished last year. National he received his Ph.D. in Synthetic American Chemical Society, the 2005 requires an annual report from each Organic Chemistry (1981) under the Distinguished Achievement Award local section; the report is compiled by direction of Dr. George A. Kraus. from Iowa State University and a 2006 your Executive Committee members, Bruce then underwent postdoctoral Pfizer Global Research and and gives details of everything that the training under the direction of Dr. Development Achievement Award. section has accomplished in the past Andrew S. Kende at the University of After taking on progressively greater year: dinner meetings, financial status, Rochester where he completed the total leadership responsibilities at Parke- educational and outreach efforts, goals synthesis of the insect antifeedant (±)- Davis and Pfizer, Bruce served as Vice for the upcoming year, and an evalua- Ajugarin IV and the anticancer agent President of Chemistry at the Pfizer tion of how well we met last year’s (±)-Quadrone. Global Research and Development, goals. Now that we have submitted Ann Arbor Laboratories from 2000- In 1982, Bruce joined the the report, National will release to the 2007. He also served as an adjunct Atherosclerosis Chemistry Section of section our share of funds needed to associate professor in the Department the Warner-Lambert/Parke-Davis Co. run all of our programming for this of Medicinal Chemistry in the School located in Ann Arbor, MI. As part of a year. project aimed at discovering inhibitors of Pharmacy of the University of Some of you will be reading this of cholesterol biosynthesis, Bruce syn- Michigan from 1996-2007. in the midst of packing/preparations thesized the compound that would In May 2007, Bruce joined for your journey to New Orleans, April ultimately be marketed as Lipitor. For Genentech Small Discovery as Senior his invention of Lipitor, Bruce received Director of Discovery Chemistry. 6-10. For those that are going, enjoy the trip and have a safe journey (and the 1997 Warner-Lambert Chairman’s Dr. Roth is the inventor or co- Distinguished Scientific Achievement inventor of 43 issued U.S. patents and listen to some jazz for me, please). Award, the 1999 “Inventor of the Year the author or co-author of 50 manu- Our May meeting will be on the Award” from the New York Intellectual scripts, 35 published abstracts, 9 book 15th, and the speaker will be Dr. Bego Property Law Association, the 2003 chapters and review articles. He has Gerber of Chemists Without Borders. American Chemical Society Award for given more than 20 invited lectures. See everyone at the April meeting. Location/Parking d lv B Genentech S.F. Bay The meeting will be in B33, and t r Gateway o r e p v N r Campus A i s people will need to come into the A vd Bl lvd y Eccle s B a Forbe Cafeteria Genentech building using the door closest to the 101 w e d Building 33 Executive D t Blv a s B33 reception area. There will be a E G e as b Grand Ave t G ra For security guard at the door to check nd Ave e E r as DNA Way people in. He will ask to see a photo Grand t G D t rand A w Parking Formerly known as s dvie Point San Bruno Blvd a an ID and have them sign the sheet prior E v Allerton Av r e G to giving them their badge. Genentech The parking lot this group will Harbor Way South Campus use is called the Upper Lot. It's locat- Driving From the North Driving From the South ed across from B20. There will be a • Take the 101 Freeway South. • Take the 101 Freeway North. sign at the lot, and I expect that • Exit at Grand Ave./South San • Exit at Grand Ave./South San Security will post 1-2 bike patrol offi- Francisco. Francisco. cers at the entrance to assist visitors. • At the bottom of the exit ramp, turn • At the bottom of the exit ramp, turn left at the light onto Airport Blvd. right onto East Grand Ave. • At stoplight, turn left onto Grand • At the first stoplight, turn right to Ave. and proceed under freeway to continue on East Grand Ave. East Grand Ave. • At the second stoplight, turn left • At the fourth stoplight, turn left onto Forbes Blvd. onto Forbes Blvd. • Continue on Forbes Blvd. for 1.3 • Continue on Forbes Blvd. for 1.3 miles until it terminates to DNA miles until it terminates at DNA Way. Way. ❖❖❖ Family Local Science Fair Activities Science The Sciencepalooza sponsored by The INTEL International Science the Synopsys Outreach Foundation and Engineering Fair will be held Night! (www.outreach-foundation.org) from May 11-16, 2008 in Atlanta GA was held on Saturday, March 1 at the and the California State Science Fair in The local SCVACS section will Santa Clara County Fairgrounds. Los Angeles will be held on May 19- be co-hosting a Family Science night Sciencepalooza encourages first time 20, 2008. at the East Palo Alto Charter School science fair entries from the East Side PLEASE NOTE - The following on Thursday April 24. We are co- Union High School District of San Jose. science day programs (Synopsys hosting this event the California About 1500 students participated. SuperSchool Seminars) will be offered Section who have run many of these Some Santa Clara Valley ACS members this summer to local K-12 teachers. very popular and successful events. were judges for the many projects. Please see the following website The East Palo Alto Charter School The Synopsys Science and for more details www.outreach- (EPACS) is a K-8 public school with Technology Championship of the foundation.org/.
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