Newsletter April 2008

Santa Clara Valley Section American Chemical Society Volume 30 No. 4

APRIL 2008 NEWSLETTER TOPICS April Dinner Meeting ® • Chair’s Message The Discovery and Development of LIPITOR Bruce Roth, Ph.D. • The Discovery and Development Come to concept of tissue selectivity of of LIPITOR April’s dinner HMGRIs and how the physicochemi- • April Dinner Meeting meeting and not cal properties of compounds in this only meet some class are related to safety and efficacy. • Family Science Night of our colleagues Biography • Local Science Fair Activities in the Bruce Roth received his BS in Section, but join • Bylaws Election Results continued on next page us also for an • Registration Open for the Short interesting pres- Course Circuit entation given by Dr. Bruce D. Roth, Senior Director Chemistry, Genentech • Call for Nominations: Shirley B. April Small Molecule Discovery. Dr. Roth is Radding Award well known for his synthesis of the Dinner Meeting • New Legislative Action Network compound known as Lipitor as well Date: Wednesday, April 23, 2008 Homepage as his many other contributions to Time: 6:00 Social Hour science. 7:00 Dinner • Chemployment Abstracts The dinner meeting will be on 8:00 Presentation April 23rd, and held at the Genentech Location: Genentech Inc. campus in South . Grandview Place/DNA Way Chair’s Message Directions, a campus map and details Building 33, Cafeteria Once again my time has gotten regarding building location, entrance South San Francisco, CA away from me, and this time I am into the building, and parking are Speaker: Dr. Bruce Roth really late. My apologies to everyone provided on the next page. Also at The Discovery and that works on the newsletter, for being the following web site: Development of LIPITOR so slow. Every rationale that I write www.gene.com/gene/contact/san- Cost: $25.00 Buffet Dinner looks like an excuse to me, and I can francisco.html Roasted Broccoli Salad w/Parmiggiano only imagine that it will look even Abstract Reggiano, Roasted Chicken w/Romesco worse to anyone else. The discovery and development Sauce, Panko Crusted Salmon with Lemon Pepper Sauce, Tiramisu for As we had no speaker or meeting of the potent HMG-CoA reductase dessert in March, I hope to see everyone at inhibitor Lipitor ( calcium), the April meeting, on the 23rd, at the largest selling drug in the history Reservations: www.scvacs.org Genentech. This will be a joint meet- of the pharmaceutical industry, will be Shirley Radding 408-246-2564 ing with the California Section, and overviewed from its design and syn- 408-296-8625 Fax the speaker will be Dr. Bruce Roth, of thesis to clinical testing. A key part of Genentech. the understanding the success of Reservations must be made by April 18th stating your name, address, This year your local section Lipitor is related to the enhanced safe- company affiliation, and number of ty and efficacy of this agent in com- Annual Report was submitted to the people in party. If you are unable to parison to other HMG-CoA reductase National ACS office on time – is that honor your reservation and do not can- inhibitors (HMGRIs). This talk will good news or what? Please, hold your cel by Monday, April 21st, you will be excitement in check. A copy of the overview the structure activity rela- invoiced following the dinner meeting. report is posted on our web site, for tionship that led to the discovery of continued on next page atorvastatin calcium as well as the April Dinner Meeting, continued from front page Creative Invention, the 2003 Gustavus Chair’s Message, continued from front page Chemistry from St. Joseph’s College in J. Esselen Award for Chemistry in the those who wish to know more about , PA (1976). He then Public Interest, sponsored by the what the Santa Clara Valley section moved to where North East Region Section of the accomplished last year. National he received his Ph.D. in Synthetic American Chemical Society, the 2005 requires an annual report from each Organic Chemistry (1981) under the Distinguished Achievement Award local section; the report is compiled by direction of Dr. George A. Kraus. from Iowa State University and a 2006 your Executive Committee members, Bruce then underwent postdoctoral Global Research and and gives details of everything that the training under the direction of Dr. Development Achievement Award. section has accomplished in the past Andrew S. Kende at the University of After taking on progressively greater year: dinner meetings, financial status, Rochester where he completed the total leadership responsibilities at Parke- educational and outreach efforts, goals synthesis of the insect antifeedant (±)- Davis and Pfizer, Bruce served as Vice for the upcoming year, and an evalua- Ajugarin IV and the anticancer agent President of Chemistry at the Pfizer tion of how well we met last year’s (±)-Quadrone. Global Research and Development, goals. Now that we have submitted Ann Arbor Laboratories from 2000- In 1982, Bruce joined the the report, National will release to the 2007. He also served as an adjunct Atherosclerosis Chemistry Section of section our share of funds needed to associate professor in the Department the Warner-Lambert/Parke-Davis Co. run all of our programming for this of Medicinal Chemistry in the School located in Ann Arbor, MI. As part of a year. project aimed at discovering inhibitors of Pharmacy of the University of Some of you will be reading this of cholesterol biosynthesis, Bruce syn- from 1996-2007. in the midst of packing/preparations thesized the compound that would In May 2007, Bruce joined for your journey to New Orleans, April ultimately be marketed as Lipitor. For Genentech Small Discovery as Senior his invention of Lipitor, Bruce received Director of Discovery Chemistry. 6-10. For those that are going, enjoy the trip and have a safe journey (and the 1997 Warner-Lambert Chairman’s Dr. Roth is the inventor or co- Distinguished Scientific Achievement inventor of 43 issued U.S. patents and listen to some jazz for me, please). Award, the 1999 “Inventor of the Year the author or co-author of 50 manu- Our May meeting will be on the Award” from the New York Intellectual scripts, 35 published abstracts, 9 book 15th, and the speaker will be Dr. Bego Property Law Association, the 2003 chapters and review articles. He has Gerber of Chemists Without Borders. American Chemical Society Award for given more than 20 invited lectures. See everyone at the April meeting.

Location/Parking d lv B Genentech S.F. Bay The meeting will be in B33, and t r Gateway o r e p v N r Campus A i s people will need to come into the A vd Bl lvd y Eccle s B a Forbe Cafeteria Genentech building using the door closest to the 101 w e d Building 33 Executive D t Blv a s B33 reception area. There will be a E G e as b Grand Ave t G ra For security guard at the door to check nd Ave e E r as DNA Way people in. He will ask to see a photo Grand t G D t rand A w Parking Formerly known as s dvie Point San Bruno Blvd a an ID and have them sign the sheet prior E v Allerton Av r e G to giving them their badge.

Genentech The parking lot this group will

Harbor Way South Campus use is called the Upper Lot. It's locat- Driving From the North Driving From the South ed across from B20. There will be a • Take the 101 Freeway South. • Take the 101 Freeway North. sign at the lot, and I expect that • Exit at Grand Ave./South San • Exit at Grand Ave./South San Security will post 1-2 bike patrol offi- Francisco. Francisco. cers at the entrance to assist visitors. • At the bottom of the exit ramp, turn • At the bottom of the exit ramp, turn left at the light onto Airport Blvd. right onto East Grand Ave. • At stoplight, turn left onto Grand • At the first stoplight, turn right to Ave. and proceed under freeway to continue on East Grand Ave. East Grand Ave. • At the second stoplight, turn left • At the fourth stoplight, turn left onto Forbes Blvd. onto Forbes Blvd. • Continue on Forbes Blvd. for 1.3 • Continue on Forbes Blvd. for 1.3 miles until it terminates to DNA miles until it terminates at DNA Way. Way. ❖❖❖ Family Local Science Fair Activities Science The Sciencepalooza sponsored by The INTEL International Science the Synopsys Outreach Foundation and Engineering Fair will be held Night! (www.outreach-foundation.org) from May 11-16, 2008 in Atlanta GA was held on Saturday, March 1 at the and the California State Science Fair in The local SCVACS section will Santa Clara County Fairgrounds. Los Angeles will be held on May 19- be co-hosting a Family Science night Sciencepalooza encourages first time 20, 2008. at the East Palo Alto Charter School science fair entries from the East Side PLEASE NOTE - The following on Thursday April 24. We are co- Union High School District of San Jose. science day programs (Synopsys hosting this event the California About 1500 students participated. SuperSchool Seminars) will be offered Section who have run many of these Some Santa Clara Valley ACS members this summer to local K-12 teachers. very popular and successful events. were judges for the many projects. Please see the following website The East Palo Alto Charter School The Synopsys Science and for more details www.outreach- (EPACS) is a K-8 public school with Technology Championship of the foundation.org/. Program topics and a strong academic emphasis and a Silicon Valley dates are listed below. goal to have all of its graduates (http://synopsys.championship.go Jun 21 Genetics and Evolution attend and complete college. They oglepages.com) was held all day on Jun 24 Color and the Nature of Light Wednesday, March 12 at the San Jose have 420 students, and expect as Jun 26 Lenses and Mirrors many as 600 students and parents to Convention Center. ACS local section members who were judges included Jun 28 Integrating Forensics into attend the science night. The EPACS Science Courses also has a partnership with Stanford professors from San Jose State U and Jul 10 Move Into Science University students who come in from IBM as well as Silver Circle Forensic Analysis: The JFK weekly for an after school science members George Lechner, Bruce Raby Jul 12 Assassination event and who run and judge their and Howard Peters. science fair. The family science night The Synopsys Science and Aug 5 Chemistry for Elementary Students will be the kickoff meeting for this Technology Championship awards year’s science fair. ceremony was held on Sunday, March Aug 6-7 Microbiology 30 at the Great American Theme Park The science night format con- in Santa Clara. Local section officers sists of many small hands-on proj- presented a total of $1,000 in prizes ects. Students move from one proj- for five selected chemistry projects. ect to the next, collecting a stamp or During the ceremony student projects sticker for each activity they com- which will advance to the INTEL Inter- plete. Each project is a short 5-10 national Science and Engineering Fair minute experiment (e.g., making (www.societyforscience.org/isef/ slime) or a longer detailed discus- index.asp) and the California State sion of the science, depending on Science Fair in Los Angeles the interest and attention span of (www.usc.edu/CSSF/) were the student. We would like to have announced. George Lechner, Howard Peters and Bruce Raby the SCV Section run 3-4 of the hands-on experiments and would greatly appreciate volunteers. The BYLAWS ELECTION RESULTS activities include making slime, The votes are in for the recently conducted election on revising the some acid-base chemistry with cab- Section’s bylaws. The tally was 244 YES, 3 NO, 1 ABSTAIN. The vote count bage indicators, making liquid nitro- was submitted to National ACS and we received their approval. So, we have a new set of bylaws that will improve our election process by allow- gen ice cream, some basic astrono- ing electronic voting on issues, such as electing new officers every year in my observing, pen and ink paper the Fall. The complete bylaws are posted on our website, www.scvacs.org, chromatography, soap bubble chem- for you to view at your leisure. The elections Committee is now working istry and building molecular models. on the mechanics of electronic voting and will make the process as easy as Please let me know if you would possible for the members. As stated in earlier articles on this subject, the like to participate. In addition, two main reasons for doing this were to make voting easy for members please let me know if you would and less expensive than the snail mail method, which we will continue to like to be involved in the planning use for those who need it. If you would like to comment on this, please of this event. It will be great fun! do by contacting a member of the Executive Committee. Natalie McClure George Lechner [email protected] Registration Open for the Short Course Circuit New Legislative Action San Francisco, CA, May 19-23, 2008 Network Homepage Registration has opened for the American Chemical Society Short Course ACS Office of Legislative and Circuit to be held in San Francisco, CA, May 19-23, 2008. Register before April Government Affairs (OLGA) is proud 21st to receive a $100 discount on your registration fee. Academic and group to announce the development of a discounts are also available. new Legislative Action Network Visit the following website for complete details. homepage called act4chemistry.org. http://ent.groundspring.org/EmailNow/pub.php?module=URLTracker&c Act4chemistry.org offers American md=track&j=197323576&u=2011307 Chemical Society members: Ð Circuit Course Calendar Ð • Current news and commentary Monday, May 19 and Tuesday, May 20 through the Act 4 Chemistry blog, Fundamentals of High Performance Liquid • Daily links to news articles of inter- Chromatography est to scientists, and Introduction to Modern Mass Spectrometry • Access to an improved legislative Drug-Like Properties in Drug Discovery action center, where ACS members Essentials of Biochemistry for Drug Hunters can send letters to policymakers. Synthetic Organic Chemistry: Modern Methods and Strategies Register: Wednesday, May 21 and Thursday, May 22 www.act4chemistry.org/register Chemical Engineering and Process Only registered participants will Fundamentals for Chemists receive notices of key decisions being Structure Based Drug Design made affecting chemistry. ACS mem- Pharmacokinetics and Pharmacodynamics: bers are encouraged to register so that Principles and Applications in Pre-Clinical they can comment on blogs and send Drug Development letters to their policymakers. Wednesday, May 21, Thursday, May 22 and Friday, May 23 Act4chemistry.org is a free pro- Statistical Analysis of Laboratory Data gram of the OLGA designed to bridge Laboratory Safety and Health the gap between policymakers and For over 30 years, ACS Continuing Education has been a respected source chemistry. If you have any questions for chemists who wish to advance or update their skills. Contact ACS Continuing please contact Brad Smith at Education at 1-800-227-5558 X4508 or via email at [email protected]. [email protected].

CALL for NOMINATIONS 2002 Paul H. L. Walter 2003 Jean'ne M. Shreeve Shirley B. Radding Award 2004 Maureen G. Chan The Santa Clara Valley Section of • Demonstrated dedicated and 2005 Glenn Fuller the American Chemical Society (ACS) unselfish service to ACS and its 2006 Janan M. Hayes announces the call for nominations members over a sustained period 2007 Merle I. Eiss for the 2008 Shirley B. Radding Award. of time. The award consists of an hono- First awarded in 1994 to its name- • Provided leadership through elected rarium of $1,000 and a suitably sake, the Shirley B. Radding Award and appointed ACS positions at inscribed memento. Nominations must annually honors someone who has local, district and national levels. consist of at least one letter of nomi- been a member of the ACS for at least • Made significant contributions to nation stating how the nominee's 20 years. Nominees must have industrial, applied or academic work relates to all aspects of the demonstrated dedicated, unselfish chemistry. award. It is strongly recommended leadership, service and significant Previous Award Recipients: that seconding letters accompany the contributions over a sustained period 1994 Shirley B. Radding nomination. of time to industrial, applied or aca- 1995 Agnes Ann Green (deceased) Nominations are due on or before demic chemistry and to the ACS 1996 John F. "Jack" Riley May 1, 2008, and must be mailed to: through elected or appointed positions 1997 Howard M. Peters Radding Award Committee at local, district and national levels. 1998 Alan C. Nixon (deceased) Santa Clara Valley Section ACS Award Criteria: 1999 Valerie J. Kuck P. O. Box 395 • Member of the American Chemical 2000 Halley A. Merrell Palo Alto, CA 94302 Society for more than twenty years. 2001 Norman A. LeBel (deceased) ❖❖❖ CHEMPLOYMENT ABSTRACTS APRIL 2008

CHEMPLOYMENT ABSTRACT 3896 CHEMPLOYMENT ABSTRACT 3897 Position Title: Senior Analytical Chemist Position Title: Associate Director, Compound Services – Medicinal Job Description: The position requires advanced knowledge and hands-on Chemistry skills in nuclear magnetic resonance (NMR), mass spectroscopy and chro- Job Description: Coordinate all aspects of compound management with matographic techniques. It uses professional concepts to solve a variety of responsibilities for a team of 5-7 scientists & research associates. Majority problems. Conceives, directs, plans, designs and executes R&D on the of time to be spent in management activities of: daily sample bank, com- basis of advanced theoretical knowledge. Analyzes outcomes, interprets pound acquisition & parallel synthesis, HTS, and compound purification. results and adjusts R&D strategy based on technical principles and theo- This is a highly collaborative role within key areas of research. ries. QUALIFICATIONS DESIRED: QUALIFICATIONS DESIRED: Education: A Ph.D. with a minimum of 6 years experience or MS with a Education: PhD/MS/BS minimum of 8 years. Experience: Ph.D. in chemistry or pharmaceutical science with 0-2 years of Experience: Typically requires 6+ years' relevant experience; in-depth experience, M.S. with more than 5 years work experience, or B.S. with knowledge of state-of-the art principles and theories, applying such more than 10 years of experience. knowledge to the research direction that supports Company interests; and LOCATION, SALARY, MAIL ADDRESS: demonstrated technical proficiency, scientific creativity, collaboration with others and independent thought in suggesting experimental design & Job Location: Menlo Park, CA research strategy. Salary: DOE LOCATION, SALARY, MAIL ADDRESS: Employer Description: SRI International, an independent non-profit organi- zation founded as the Stanford Research Institute in 1946, is a leader in the Job Location: Foster City, CA development of new products for the treatment and diagnosis of disease, Salary: DOE primarily in the areas of cancer, infectious disease, neuroscience, and Employer Description: Gilead Sciences is a biopharmaceutical company that immunology. discovers, develops and commercializes therapeutics to advance the care Application Instructions: Apply via our web page at: of patients suffering from life-threatening diseases worldwide. https://sri.ats.hrsmart.com/cgi-bin/a/highlightjob.cgi?jobid=3946 Application Instructions: Apply online at: SRI is an equal opportunity employer. http://www.sri.com/jobs http://gilead.apply2jobs.com/index.cfm?fuseaction=mExternal.showJob&RI D=941&CurrentPage=1

CHEMPLOYMENT ABSTRACT 3899 CHEMPLOYMENT ABSTRACT 3900 Position Title: Research Assistant Position Title: Chemist and Lab Manager Job Description: The Research Assistant (RA) will be trained in, and Job Description: Management of waste treatment and recycling; staying cur- responsible for, the use of a circular dichroism spectrometer, UV-vis spec- rent on all applicable waste treatment compliance requirements; manag- trometer, a precision density meter, and two ultrasensitive calorimeters. ing of lab technicians; training and managing waste treatment operators; The RA will maintain a clean and organized working environment for all monitoring process tanks and maintaining related records; assisting with laboratory members, and the RA will train and mentor research students facilities issues, such as requesting waste treatment equipment and sup- in the proper use of instrumentation. Further information may be found at plies; initiating projects for continuous improvement and advancing sus- the supervisor’s website: http://www.chemistry.sjsu.edu/deggers/home- tainability of operations. page.htm QUALIFICATIONS DESIRED: QUALIFICATIONS DESIRED: Education: B.S. or greater in Chemistry or Chemical Engineering Education: B.S. or M.S. degree in Chemistry, Biochemistry, Biochemical Experience: Prefer 10 years experience in an industrial setting with hands- Engineering, or equivalent. on management of waste treatment operations and chemical laboratory Experience: Experience working in a research environment is desirable. operations. Excellent verbal communication skills are mandatory. A minimum commit- LOCATION, SALARY, MAIL ADDRESS: ment of one year in this position is expected. Job Location: Hayward, CA LOCATION, SALARY, MAIL ADDRESS: Salary: Negotiable, depending on qualifications and experience Job Location: San Jose State University, San Jose, CA Employer Description: A major player in precision chemical cleaning, serv- Salary: Negotiable. ing the needs of the semiconductor industry and other high technology Employer Description: The RA will be paid from a grant administered by businesses; Closely-held for 25 years, ISO 9001-2000 certified; fully com- the SJSU Research Foundation. Foundation employment is separate and mitted to spearheading "green" practices in waste treatment, processing, distinct from SJSU or State of California employment. and reclamation. Application Instructions: Send letter of interest, resume, and the names Application Instructions: Please visit website at www.tmpi-quickclean.com and contact information of at least two references by post, email or fax to: for more information. Interested persons, please email resume to Dr. Daryl K. Eggers, Chemistry Department, SJSU, San Jose, CA 95192- [email protected] with copy to [email protected]. 0101; (E-mail) [email protected]; (Fax) 408-924-4945.

The Santa Clara Valley Section of the American Chemical Society is the copyright owner of all material published in The Silicon Valley Chemist. No part of this publi- cation may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without advance permission in writing from the editor, particularly for commercial purposes. Authorization to photocopy items for limited internal or personal use, or the limited internal or personal use of specific clients, is granted by the Executive Committee of the Santa Clara Valley Section of the American Chemical Society. SANTA CLARA VALLEY SECTION AMERICAN CHEMICAL SOCIETY P.O. Box 395, Palo Alto, CA 94302

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SANTA CLARA VALLEY SECTION FUTURE MEETINGS 2008 Section Officers Apr 6-10 National ACS Meeting Chair Mark Kent 408-736-0989 [email protected] Joint with AIChE Chair-Elect Natalie McClure 650-906-7831 [email protected] New Orleans, LA Past Chair George Lechner 408-226-7262 [email protected] Secretary Karl Marhenke 831-688-4959 [email protected] Apr 19 UNESCO National Chemistry Treasurer Herb Silber 408-924-4954 [email protected] Olympiad Exam Livermore, CA Councilors 2006-2008 Abby Kennedy 209-640-2005 [email protected] Apr 23 Section Dinner Meeting 2006-2008 Ean Warren 650-329-4554 [email protected] Discovery and Development 2007-2009 Linda Brunauer 408-554-6947 [email protected] of LIPITOR 2007-2009 Sally Peters 650-812-4994 [email protected] Dr. Bruce Roth 2007-2009 Peter Rusch 650-961-8120 [email protected] Genentech, Inc. 2008-2010 George Lechner 408-226-7262 [email protected] South San Francisco, CA 2008-2010 Herb Silber 408-924-4954 [email protected] 2008 Howard Peters 650-854-4614 [email protected] Apr 24 Family Science Night Joint activity with CA section Alternate Councilors East Palo Alto Charter School 2006-2008 Ihab Darwish 650-594-1654 [email protected] 2006-2008 David Parker 408-615-4961 [email protected] Volunteers Needed 2006-2008 Bruce Raby 408-294-6718 [email protected] [email protected] 2007-2009 Stephanie Gehling 408-261-3974 [email protected] Apr 29 46th AIChE Annual Symposium 2007-2009 Natalie McClure 650-906-7831 [email protected] South San Francisco Conference 2007-2009 Maureen Scharberg 408-924-4966 [email protected] Center 2008-2010 Mark Kent 408-736-0989 [email protected] http://aiche-norcal.org/symposium.php 2008-2010 Ferenc Makra 650-855-5368 [email protected] May 15 Section Dinner Meeting Newsletter Chemists Without Borders Editor: Cinzia Muzzi 408-864-5790 [email protected] Dr. Bego Gerber ChemPloyment Abstracts Biltmore Hotel, Santa Clara, CA Director: Charles Sullivan 650-359-0731 [email protected]