Complex Systems in Biology & Risk Assessment

www.ems-us.org st 41Annual Meeting

Texas

October 23–27, 2010 Omni Fort Worth

EMS President: Plenary Lecturers: Michael J. Plewa Stephen B. Baylin Julia A. Ross Program Chair: Thomas W. Kensler Samuel H. Wilson James R. Lupski Jeffrey L. Schwartz

Sponsors of the 41st Annual Meeting Platinum National Institute of The Procter & Gamble Company Environmental Health Sciences, U.S. Food and Drug NIH Grant No. 1R13ES019783 Administration The Ellison Medical Foundation Grant No. 5R13FD003830-02 No. AG-CW-0317-10 Gold Elsevier Research Corporation for Science Advancement March of Dimes Birth Defects Foundation Silver Amgen Johnson & Johnson PRD (OMP2319) BioReliance Corporation Lhasa Limited Boehringer Ingelheim Litron Laboratories Pharmaceuticals, Inc. MolTox Fanconi Anemia Research Fund Office of Research in Women’s Health, NIH Federation of American Societies for Experimental Biology (FASEB) Pfizer Inc. GlaxoSmithKline sanofi aventis ILSI-HESI IVGT Project Committee Society of Toxicology Integrated Laboratory Systems, Inc. Bronze

Anonymous Contributor EpiGenie.com Environmental and Molecular Mutagenesis Genetic Toxicology Association Editorial Office Philip C. Hanawalt Complex Systems in Biology & Risk Assessment Welco st me! 41Annual Meeting

Texas

October 23–27, 2010 Omni Fort Worth Program Program Chair: Jeffrey L. Schwartz, Ph.D.

Abstracts printed in Environmental and Molecular Mutagenesis Volume 51, Number 7 The Environmental Mutagen Society was founded in 1969 and is incorporated under the laws of the District of Columbia. Its purpose is to encourage the study of mutagens in the human environment, particularly as they may affect public health, and to engage in and sponsor research and the dissemination of information related to mutagens. Membership is open to all interested scientists. All text and graphics are copyright © 2010 by the Environmental Mutagen Society and may not be used or duplicated without written consent from the Society. Some photographs are courtesy of the Fort Worth Convention and Visitors Bureau and Omni Fort Worth Hotel, unless stated otherwise. 41st Annual Meeting of the Environmental Mutagen Society

Table of Contents Meeting Overview Meeting Overview ...... 2 Friday, October 22 EMS Officers ...... 5 EMS Councilors 2010–2013...... 5 4:00 PM–6:00 PM Texas Ballroom Foyer Past Presidents ...... 5 REGISTRATION Headquarters Staff...... 5 Committees 2009–2010 ...... 6 Saturday, October 23 Special Interest Group Leaders...... 8 8:00 AM–6:00 PM Texas Ballroom Foyer Council Task Forces...... 8 REGISTRATION EMS Committee Meetings...... 9 8:00 AM–12:15 PM Texas Ballroom F EMS Special Interest Groups...... 9 ADVANCEMENTS IN APPLIED GENETIC Welcome Reception and TOXICOLOGY WORKSHOP Student and New Investigator Poster Session...... 9 Town Hall Meeting...... 9 9:00 AM–12:00 NOON Sundance 1 EMS EXECUTIVE BOARD MEETING Sponsored Events...... 10 General Information 9:30 AM–4:30 PM Texas Ballroom G Welcome to the 41st CAREER DEVELOPMENT WORKSHOP EMS Annual Meeting...... 12 12:15 PM–5:00 PM Texas Ballroom F Meeting Highlights...... 12 GENOTOXICITY OF NANOMATERIALS: Registration Hours ...... 12 REFINING STRATEGIES AND TESTS FOR HAZARD Exhibit and Poster Hours ...... 12 IDENTIFICATION WORKSHOP

Author Attended Poster Hours...... 12 12:30 PM–4:00 PM Stockyards 1 Poster Presentations ...... 12 EMS COUNCIL MEETING Photography Policy...... 13 4:30 PM–6:30 PM Texas Ballroom E First Aid and Security...... 13 WELCOME RECEPTION AND Internet Access STUDENT AND NEW INVESTIGATOR POSTER SESSION at the Annual Meeting...... 13

Conference Site...... 13 Sunday, October 24 Ground Transportation: Getting around Fort Worth...... 13 7:00 AM–5:00 PM Texas Ballroom Foyer Parking ...... 13 REGISTRATION

Meals...... 13 7:00 AM–8:30 AM Agenda BREAKFAST MEETINGS Friday ...... 14 Applied Genetic Toxicology SIG Sundance 4 Saturday ...... 14 DNA Repair and Mutagenic Mechanisms SIG Sundance 3 Sunday...... 15 Transgenic and In Vivo Mutagenesis SIG Sundance 2 Monday...... 21 Tuesday...... 28 8:30 AM–9:30 AM Texas Ballroom F PLENARY LECTURE 1 Wednesday ...... 31 Genomic Disorders: Mechanisms and Assays for CNV Future Meetings ...... 32 Associated with Human Disease Traits Exhibits...... 36 Lecturer: James R. Lupski, Baylor College of Medicine Omni Fort Worth Restaurants...... 38 Maps of Omni Fort Worth...... 39

2 Fort Worth, Texas, U.S.A. • October 23–27, 2010

9:45 AM–12:15 PM Texas Ballroom F 8:30 AM–9:30 AM Texas Ballroom F SYMPOSIUM 1 PLENARY LECTURE 2 Replication Stress: Environmental Causes, Cellular Responses, Chronic Cell Stress, Cancer, and the Epigenome and Mutational Consequences Lecturer: Stephen B. Baylin, The Johns Hopkins University School of Medicine 9:45 AM–12:30 PM Texas Ballroom G SYMPOSIUM 2 9:45 AM–12:15 PM Texas Ballroom G Is Tobacco Smoke a Germ-Cell Mutagen? SYMPOSIUM 6 RNA Silencing: Mechanism, Biology and Responses to 12:45 PM–2:00 PM Texas Ballroom F Environmental Stress TOWN HALL MEETING EMS Connect: Welcome to the 21st Century 9:45 AM–12:15 PM Texas Ballroom F SYMPOSIUM 7 2:15 PM–4:30 PM Texas Ballroom G Cognitive Consequences of Fetal and Early Postnatal Exposure to SYMPOSIUM 3 Environmental Contaminants DNA Interstrand Crosslinks: Repair, Cell Signaling, and Therapeutic Implications 12:15 PM–1:00 PM Texas Ballroom F BUSINESS MEETING 2:15 PM–4:30 PM Texas Ballroom F SYMPOSIUM 4 1:00 PM–2:00 PM Stockyards 1 Telomeres, Aging, and Human Disease STUDENT AND NEW INVESTIGATOR BRUNCH

2:15 PM–4:30 PM Texas Ballroom I 2:15 PM–4:30 PM Texas Ballroom F SYMPOSIUM 5 SYMPOSIUM 8 Next Generation Sequencing Technology and Applications Mitochondria Mutagenesis and Disease

4:30 PM–6:30 PM Texas Ballroom E 2:15 PM–4:30 PM Texas Ballroom G POSTER SESSION 1 AND EXHIBITS SYMPOSIUM 9 Odd Numbered Abstracts Attended Advances and Use of Toxicogenomics in Risk Assessment

6:30 PM–8:30 PM 2:15 PM–4:30 PM Texas Ballroom I COMMITTEE MEETINGS PLATFORM SESSION 1 2011 Program Committee Meeting (First Meeting) Fort Worth 1 DNA Repair Awards and Honors Committee Fort Worth 2 4:30 PM–6:30 PM Texas Ballroom E Web Site Committee Fort Worth 3 POSTER SESSION 2 AND EXHIBITS Even Numbered Abstracts Attended

Monday, October 25 6:30 PM–8:30 PM

7:00 AM–5:00 PM Texas Ballroom Foyer COMMITTEE MEETINGS REGISTRATION Education, Student and New Investigator Fort Worth 1 Affairs Committee 7:00 AM–8:30 AM Public Relations and Communications Committee Fort Worth 2 BREAKFAST MEETINGS Membership and Professional SUNDANCE 2 Epigenetics SIG Sundance 3 Development Committee and Special Interest Group Leaders New Technologies SIG Sundance 2

8:30 AM–6:30 PM Texas Ballroom E POSTERS AND EXHIBITS OPEN

3 41st Annual Meeting of the Environmental Mutagen Society

Tuesday, October 26 6:15 PM–7:15 PM Texas Ballroom F EMS AWARD LECTURE 7:00 AM–5:00 PM Texas Ballroom Foyer Base Excision Repair and Environmental Mutagenesis REGISTRATION Award Recipient: Samuel H. Wilson, National Institute of Environmental Health Sciences 7:00 AM–8:30 AM BREAKFAST MEETINGS 7:30 PM–11:00 PM Texas Ballroom E Executive Board Meeting Sundance 4 EMS BANQUET Awards Presentation by Michael J. Plewa Heritable Mutation and Disease SIG Sundance 3 Alexander Hollaender Award Risk Assessment SIG Sundance 2 EMS Service Award Student Education Award 8:30 AM–11:30 AM Texas Ballroom E Student and New Investigator Travel Awards POSTERS AND EXHIBITS OPEN Dancing to the Music of The Genotones Last Chance to View Posters and Exhibits!

8:30 AM–9:30 AM Texas Ballroom F Wednesday, October 27 PLENARY LECTURE 3 Keap1 Eye on NRF2: Targets for Disease Prevention 7:00 AM–11:30 AM Texas Ballroom Foyer Lecturer: Thomas W. Kensler, University of Pittsburgh REGISTRATION

9:45 AM–12:15 PM Texas Ballroom F 7:00 AM–8:30 AM SYMPOSIUM 10 BREAKFAST MEETINGS Inflammation: From Molecules to Human Populations Environmental Genetic Toxicology SIG Sundance 3 9:45 AM–12:15 PM Texas Ballroom G Finance Committee Sundance 4 SYMPOSIUM 11 Molecular Epidemiology SIG Sundance 2 Biomarkers of Exposure 8:30 AM–9:30 AM Texas Ballroom F 12:30 PM–2:00 PM Sundance 2 PLENARY LECTURE 4 WEMS LUNCHEON WEMS: Interdisciplinary Collaborations: A Big-Picture The Leaky Pipeline of Women in Science: Patching the Pipe Approach toward Understanding the Causes and Consequences or Rebuilding the Infrastructure? of Childhood Cancer Lecturer: Carrie D. Wolinetz, Association of American Lecturer: Julie A. Ross, University of Minnesota Cancer Center Universities 9:45 AM–12:15 PM Texas Ballroom G 12:45 PM–2:00 PM Sundance 3 SYMPOSIUM 14 HOLLAENDER COMMITTEE MEETING Fragile-X Syndrome: Genes to Therapy

2:15 PM–4:15 PM Texas Ballroom F 9:45 AM–12:15 PM Texas Ballroom F SYMPOSIUM 12 SYMPOSIUM 15 DNA Repair, Epigenetics, and Genomic Stability Genetic Toxicology of Wildlife and Other Indicator Species

2:15 PM–4:15 PM Texas Ballroom G 12:30 PM–1:45 PM PLATFORM SESSION 2 COMMITTEE MEETINGS Heritable Mutations/Cancer 2011 Program Committee (Second Meeting) Sundance 3 2:15 PM–4:15 PM Texas Ballroom I Publication Policy Committee Sundance 4 PLATFORM SESSION 3 Toxicology 1:45 PM–3:00 PM Sundance 1 EMS COUNCIL MEETING 4:30 PM–5:45 PM Texas Ballroom F SYMPOSIUM 13 Cytogenetics and EMS: The Shelly Wolff Legacy

4 Fort Worth, Texas, U.S.A. • October 23–27, 2010

EMS Officers Michael J. Plewa, Ph.D., President Suzanne M. Morris, Ph.D., Secretary University of Illinois at Urbana-Champaign National Center for Toxicological Research, U.S. FDA Jeffrey L. Schwartz, Ph.D., President-Elect Catherine B. Klein, Ph.D., President-Elect 2010–2011 University of Washington New York University School of Medicine Barbara S. Shane, Ph.D., DABT, Treasurer EMS Councilors 2010–2013 William M. Baird, Ph.D. (2010) Olga Kovalchuk, Ph.D. (2011) Thomas E. Wilson, M.D., Ph.D. (2012) Rosalie K. Elespuru, Ph.D. (2010) Ofelia A. Olivero, Ph.D. (2011) Janet E. Baulch, Ph.D. (2013) Patricia Ostrosky-Wegman, Ph.D. (2010) Karen M. Vasquez, Ph.D. (2011) Stephen D. Dertinger, Ph.D. (2013) Miriam C. Poirier, Ph.D. (2010) Andrew B. Buermeyer, Ph.D. (2012) Brinda Mahadevan, Ph.D. (2013) Jonathan B. Ward, Jr., Ph.D. (2010) Krista L. Dobo (2012) Christopher M. Somers, Ph.D. (2013) Jason H. Bielas, Ph.D. (2011) Patricia A. Escobar, Ph.D. (2012) Kandace J. Williams, Ph.D. (2013) Bevin P. Engelward, Sc.D. (2011) Francesco Marchetti, Ph.D. (2012) Past Presidents Alexander Hollaender, Ph.D. (1970) Michael D. Shelby, Ph.D. (1985) Sid Aaron, Ph.D., DABT (1997) Ernst Freese, Ph.D. (1972) John A. Heddle, Ph.D. (1986) Rosalie K. Elespuru, Ph.D. (1998) Frederick J. de Serres, Ph.D. (1974) Anthony V. Carrano, Ph.D. (1987) James S. Felton, Ph.D. (1999) Jan Drake, Ph.D. (1976) Sheila M. Galloway, Ph.D. (1988) James D. Tucker, Ph.D. (2000) Seymour Abrahamson, Ph.D. (1977) R. Julian Preston, Ph.D. (1989) David M. DeMarini, Ph.D. (2001) David J. Brusick, Ph.D., ATS (1978) George R. Hoffmann, Ph.D. (1990) Lawrence A. Loeb, M.D., Ph.D. (2002) Mortimer L. Mendelsohn, M.D., Ph.D. (1979) Michael D. Waters, Ph.D. (1991) David A. Eastmond, Ph.D. (2003) Sheldon Wolff, Ph.D. (1980) James T. MacGregor, Ph.D., DABT (1992) Leona D. Samson, Ph.D. (2004) Verne A. Ray, Ph.D. (1981) Philip C. Hanawalt, Ph.D. (1993) Peter J. Stambrook, Ph.D. (2005) Gordon W. Newell, Ph.D. (1982) James M. Gentile, Ph.D. (1994) Martina L. Veigl, Ph.D. (2006) Richard J. Albertini, M.D., Ph.D. (1983) Raymond R. Tice, Ph.D. (1995) Andrew J. Wyrobek, Ph.D. (2007) Liane B. Russell, Ph.D. (1984) Raymond W. Tennant, Ph.D. (1996) Priscilla K. Cooper, Ph.D. (2008) Headquarters Staff Tonia M. Masson, Executive Director Maureen Kettering, Meetings and Exhibits Manager Becca Isakower, Program Manager Christy Ours, Program Assistant

5 41st Annual Meeting of the Environmental Mutagen Society

Committees 2009–2010 Alexander Hollaender Mats Ljungman, Ph.D., Chair David M. DeMarini, Ph.D. Joginder Nath, Ph.D. Philip C. Hanawalt, Ph.D., Co-Chair James M. Gentile, Ph.D. Patricia Ostrosky-Wegman, Ph.D. Anane Ben Aidoo, Ph.D. Helena Groot de Restrepo, Ph.D. Lucia Regina Ribeiro, Ph.D. William W. Au, Ph.D. Philip C. Hanawalt, Ph.D. Delbert M. Shankel, Ph.D. William M. Baird, Ph.D. Nina T. Holland, Ph.D. Peter J. Stambrook, Ph.D. Priscilla K. Cooper, Ph.D. Gopala Krishna, Ph.D., DABT, M.B.A. Michael D. Waters, Ph.D. Meredith E. Crosby, Ph.D. Mugimane Manjanatha, Ph.D. Paul A. White, Ph.D.

Awards and Honors Andrew B. Buermeyer, Ph.D., Chair Rosalie K. Elespuru, Ph.D. Takehiko Nohmi, Ph.D. Richard D. Wood, Ph.D., Co-Chair Bevin P. Engelward, Sc.D. Jennifer C. Sasaki, Ph.D. P.J. Brooks, Ph.D., Past Chair James M. Gentile, Ph.D.

Editor-in-Chief Search Robert H. Heflich, Ph.D., Chair Bevin P. Engelward, Sc.D. William F. Morgan, Ph.D., D.Sc. George R. Hoffmann, Ph.D., Vice Chair Sheila M. Galloway, Ph.D. Graciela Spivak, Ph.D. Priscilla K. Cooper, Ph.D. Malcolm J. Lippert, Ph.D. Raymond R. Tice, Ph.D.

Education, Student and New Investigator Affairs Olga Kovalchuk, Ph.D., Chair Robert H. Heflich, Ph.D. Aris A. Polyzos, Ph.D. Hilde E. van Gijssel, Ph.D., Co-Chair Kathleen A. Hill, Ph.D. Peter J. Stambrook, Ph.D. Amal M. Abu-Shakra, Ph.D. Catherine B. Klein, Ph.D. Esther Tiedtke Meredith E. Crosby, Ph.D. Suzanne M. Morris, Ph.D. Jonathan B. Ward, Jr., Ph.D. David M. DeMarini, Ph.D. John J. Mulvihill, M.D. Paul A. White, Ph.D. Glenda J. Gentile Ofelia A. Olivero, Ph.D. Robert R. Young James M. Gentile, Ph.D. Janice M. Pluth, Ph.D.

FASEB Representatives Laura J. Niedernhofer, M.D., Ph.D., Karen M. Vasquez, Ph.D., Joann B. Sweasy, Ph.D., FASEB Board Peer Review Subcommittee FASEB Journal Editorial Board Robert H. Heflich, Ph.D., FASEB PCC

Finance and Resource Ronald D. Snyder, Ph.D., Chair James C. Fuscoe, Ph.D., Council Liaison Michael J. Plewa, Ph.D. Andrew D. Kligerman, Ph.D., Co-Chair David A. Eastmond, Ph.D. Barbara S. Shane, Ph.D., DABT, Treasurer Barbara L. Parsons, Ph.D.

6 Fort Worth, Texas, U.S.A. • October 23–27, 2010

Membership and Professional Development Ofelia A. Olivero, Ph.D., Chair E. Maria Donner, Ph.D. Robert C. von Borstel, Ph.D., D.Sc. Kandace J. Williams, Ph.D., Chair Michael Edelbrock, Ph.D. Elizabeth S. Von Halle Sid Aaron, Ph.D., DABT Barry N. Ford, Ph.D. Jonathan B. Ward, Jr., Ph.D. R. Daniel Benz, Ph.D. David J. Kirkland, B.Sc., Ph.D. Andrew J. Wyrobek, Ph.D. Stefano Bonassi, Ph.D. Catherine B. Klein, Ph.D. Special Interest Group Leaders Junjian Chen, Ph.D. Suzanne M. Morris, Ph.D.

Nominating Andrew J. Wyrobek, Ph.D., Chair Nagu Keshava, Ph.D. James D. Tucker, Ph.D. Priscilla K. Cooper, Ph.D., Co-Chair William F. Morgan, Ph.D., D.Sc. Carole L. Yauk, M.Sc., Ph.D. Jonathan B. Ward, Jr., Ph.D., EB Liaison Suzanne M. Morris, Ph.D. Errol Zeiger, Ph.D. Patricia A. Escobar, Ph.D. Barbara L. Parsons, Ph.D. Sheila M. Galloway, Ph.D. Joann B. Sweasy, Ph.D.

Program Jeffrey L. Schwartz, Ph.D. Barbara S. Shane, Ph.D., DABT Andrew J. Wyrobek, Ph.D. David M. DeMarini, Ph.D. Stephanie L. Smith-Roe, Ph.D. Session Organizers Laura J. Niedernhofer, M.D., Ph.D. Peter J. Stambrook, Ph.D. Special Interest Group Leaders Jeffrey A. Ross, Ph.D. Paul A. White, Ph.D.

Public Relations and Communications Mugimane Manjanatha, Ph.D., Chair Catherine B. Klein, Ph.D. Barbara L. Parsons, Ph.D. Jeffrey K. Wickliffe, Ph.D., Co-Chair Pamela S. Lee Jeffrey L. Schwartz, Ph.D. R. Daniel Benz, Ph.D. Suzanne M. Morris, Ph.D., Secretary Carlos A. Torres-Ramos, Ph.D. Barry N. Ford, Ph.D., Web Master John J. Mulvihill, M.D. Laura J. Niedernhofer, M.D., Ph.D., Kathleen A. Hill, Ph.D. Patricia Ostrosky-Wegman, Ph.D. FASEB Representative

Publication Policy Malcolm J. Lippert, Ph.D., Chair Robert H. Heflich, Ph.D. Ronald D. Snyder, Ph.D. Stephen D. Dertinger, Ph.D., Co-Chair George R. Hoffmann, Ph.D. Peter J. Stambrook, Ph.D. Larry D. Claxton, Ph.D. Malcolm J. Lippert, Ph.D. Kristine L. Witt, M.S. Sheila M. Galloway, Ph.D. Michael D. Shelby, Ph.D. Errol Zeiger, Ph.D.

Web Site Martina L. Veigl, Ph.D., Chair Bevin P. Engelward, Sc.D. John A. Tainer, Ph.D. Barry N. Ford, Ph.D., Co-Chair Mats Ljungman, Ph.D. Hilde E. van Gijssel, Ph.D. R. Daniel Benz, Ph.D. Ofelia A. Olivero, Ph.D.

7 41st Annual Meeting of the Environmental Mutagen Society

Special Interest Group Leaders Applied Genetic Toxicology* Epigenetics Risk Assessment Krista L. Dobo Janet E. Baulch, Ph.D. David A. Eastmond, Ph.D. Patricia A. Escobar, Ph.D. Catherine B. Klein, Ph.D. Nagu Keshava, Ph.D.

DNA Repair and Mutagenic Heritable Mutation and Disease Transgenics in In Vivo Mechanisms Francesco Marchetti, Ph.D. Mutagenesis Mats Ljungman, Ph.D. Carole L. Yauk, M.Sc., Ph.D. Kathleen A. Hill, Ph.D. Joann B. Sweasy, Ph.D. Mugimane Manjanatha, Ph.D. Molecular Epidemiology Environmental Genetic Miriam C. Poirier, Ph.D. Women in the EMS Toxicology* Radim J. Sram, M.D., D.Sc. Glenda J. Gentile Christopher M. Somers Janice M. Pluth, Ph.D. Carol D. Swartz, Ph.D. New Technologies Patricia A. Escobar, Ph.D. Brinda Mahadevan, Ph.D. *Indicates a new Special Interest Group Council Task Forces By-Laws Social Networking Platform Regulatory Policy Suzanne M. Morris, Ph.D., Chair Ofelia A. Olivero, Ph.D., Chair Rosalie K. Elespuru, Ph.D., Co-Leader Stephen D. Dertinger, Ph.D. William M. Baird, Ph.D. Nagu Keshava, Ph.D., Co-Leader Rosalie K. Elespuru, Ph.D. Andrew B. Buermeyer, Ph.D. Jeffrey L. Schwartz, Ph.D. Miriam C. Poirier, Ph.D. Daniel Anthony Casciano, Ph.D. Andrew J. Wyrobek, Ph.D Kevin S. Sweder, Ph.D. Krista L. Dobo Kandace J. Williams, Ph.D. Patricia A. Escobar, Ph.D. Tonia M. Masson, Executive Director Catherine B. Klein, Ph.D. Rohan Kulkarni Committee Governance Brinda Mahadevan, Ph.D. Jonathan B. Ward, Jr., Ph.D., Chair Francesco Marchetti, Ph.D. Jason H. Bielas, Ph.D. Suzanne M. Morris, Ph.D. Bevin P. Engelward, Sc.D. Patricia Ostrosky-Wegman, Ph.D. Karen M. Vasquez, Ph.D. Michael J. Plewa, Ph.D. Thomas E. Wilson, M.D., Ph.D. Margaret Pratt, Ph.D. Jeffrey L. Schwartz, Ph.D. Martina L. Veigl, Ph.D. Tonia M. Masson, Executive Director

8 Fort Worth, Texas, U.S.A. • October 23–27, 2010

EMS Committee Meetings The EMS committees are active throughout the year and have Contact the committee chair if you are interested in serving at least one organized meeting during the conference. The on a committee. The Committee meetings will be held on the committees are meeting on Sunday through Wednesday as second and third floors. See diagram on page 39. noted in the program. Members are encouraged to be involved in a committee. EMS Special Interest Groups The breakfast meetings of the Society SIGs are a time- The Women in EMS SIG is presenting a lunchtime meeting on tested favorite of the Annual Meetings. The format provides Tuesday at 12:30 PM. Separate registration is required for the free-form discussions and short presentations of the key SIG meetings. The SIG meetings will be held on the second challenges. The SIGs provide a casual way for young and third floors. See diagram on page 39. investigators and seasoned researchers to interact. The SIG breakfast meetings are scheduled Sunday through Wednesday as noted in the program. Welcome Reception and Student and New Investigator Poster Session The Welcome Reception will take place at 4:30 PM on Registered meeting attendees should join your colleagues on Saturday in Texas Ballroom E. The Student and New Saturday to catch up with friends, socialize, meet the up-and- Investigator Poster Session is part of the Welcome Reception. coming future leaders of EMS, and engage in stimulating All students and new investigators presenting during the discussions on the causes and consequences of damage to the meeting should put their poster on display—it is one more genome and epigenome. opportunity to highlight your research and is in addition to your scheduled presentation. Town Hall Meeting Sunday, October 24 12:45 PM–2:00 PM

The 2010 Town Hall Meeting will update the membership on the new EMS Connect. The discussion will be led by Ofelia A. Olivero. Come learn how to use this newest member benefit and stay connected with other members throughout the year.

9 41st Annual Meeting of the Environmental Mutagen Society

Sponsored Events Saturday, October 23 Sunday, October 24

Advancements in Applied Genetic Applied Genetic Toxicology Special Toxicology Workshop Interest Group Contributing Sponsors: MolTox, Pfizer Inc., and Contributing Sponsor: BioReliance Corporation sanofi aventis Symposium 1 Supported in part by: BioReliance Corporation Replication Stress: Environmental Causes, Cellular Responses, and Career Development Workshop Mutational Consequences Contributing Sponsors: Federation of American Supported in part by: Phillip C. Hanawalt Societies for Experimental Biology (FASEB) and Research Corporation for Science Symposium 2 Is Tobacco Smoke a Germ-Cell Mutagen? Advancement Supported in part by: Anonymous Contributor Genotoxicity of Nanomaterials: Refining Strategies and Tests for Hazard Symposium 3 Identification Workshop DNA Interstrand Crosslinks: Repair, Cell Signaling, and Therapeutic Primary Sponsor: The Procter & Gamble Implications Company Supported in part by: Fanconi Anemia Research Contributing Sponsors: ILSI-HESI IVGT Fund Project Committee and sanofi aventis Monday, October 25 WELCOME RECEPTION AND STUDENT and NEW INVESTIGATOR Symposium 6 POSTER SESSION RNA Silencing: Mechanism, Biology and Responses to Environmental Stress Supported in part by: Genetic Toxicology Contributing Sponsor: Elsevier Association Symposium 8 Mitochondria Mutagenesis and Disease Primary Sponsor: The Ellison Medical Foundation No. AG-CW-0317-10

10 Fort Worth, Texas, U.S.A. • October 23–27, 2010

Tuesday, October 26 General meeting sponsors

WEMS LUNCHEON Amgen THE LEAKY PIPELINE OF WOMEN IN SCIENCE: PATCHING THE PIPE OR REBUILDING THE Boehringer Ingelheim Pharmaceuticals, Inc. INFRASTRUCTURE? Primary Sponsor: Research Corporation for EpiGenie.com Science Advancement GlaxoSmithKline Symposium 12 Johnson & Johnson PRD (OMP2319) DNA Repair, Epigenetics, and Genomic Stability Lhasa Limited Supported in part by: Integrated Laboratory Systems Litron Laboratories National Institute of Environmental Health Wednesday, October 27 Sciences, NIH Grant No. 1R13ES019783 Symposium 14 Fragile-X Syndrome: Genes to Therapy Society of Toxicology Supported in part by: March of Dimes Birth U.S. Food and Drug Administration Defects Foundation Grant No. 5R13FD003830-02

STUDENT AND NEW INVESTIGATOR Presentation AWARDS

Environmental and Molecular Mutagenesis Editorial Office

STUDENT AND NEW INVESTIGATOR TRAVEL AWARDS

National Institute of Environmental Health Sciences, NIH Grant No. 1R13ES019783

11 41st Annual Meeting of the Environmental Mutagen Society

General Information Welcome to the 41st EMS Annual Meeting The meeting concludes at Noon on Wednesday with one more blast of science to help keep you transfixed on future You are now part of history. Since 1969 distinguished possibilities and collaborations as you return home. scientists including Drs. Alexander Hollaender, Joshua Lederberg, James Crow, James Neel, William Russell, Heinrich Malling, Frederick J. de Serres, and Matthew Registration Hours Meselson have attended EMS meetings. The Society was Registration is located in the Texas Ballroom Foyer. founded to provide a forum for the establishment and support Friday 4:00 PM–6:00 PM of scientists in the field of environmental mutagenesis. Saturday 8:00 AM–6:00 PM Over the past 41 years our Society has helped shape public Sunday 7:00 AM–5:00 PM policy on the environment by providing critical information Monday 7:00 AM–5:00 PM on environmental mutagens. Our work has only grown Tuesday 7:00 AM–5:00 PM in importance. While the initial focus of EMS was on Wednesday 7:00 AM–11:30 AM germ-cell mutagenesis, today the EMS is the primary professional society for scientists involved in understanding mechanisms of DNA repair and mutagenesis, the role of the Exhibit and Poster Hours epigenome, consequences of mutation such as cancer, and Sunday 4:30 PM–6:30 PM the evaluation of risk from genotoxic agents for mutagenesis, Monday 8:30 AM–6:30 PM carcinogenesis, birth defects, and other disorders. Tuesday 8:30 AM–11:30 AM

Meeting Highlights Author Attended Poster Hours The meeting will officially open on Saturday with a series Sunday 4:30 PM–6:30 PM of workshops including a special workshop on career Odd numbered abstracts attended development that will highlight the diverse career paths Monday 4:30 PM–6:30 PM available for our students, postdocs, and early career Even numbered abstracts attended scientists. This year’s program includes four plenary lectures. The topics are Copy-Number Variation and Disease (Sunday), Chronic Cell Stress, Cancer, and the Epigenome Poster Presentations (Monday), Targets for Disease Prevention (Tuesday), and The posters will be displayed in Texas Ballroom E. Understanding the Causes and Consequences of Childhood Posters should be installed between 12:00 NOON– Cancer (Wednesday). 4:00 PM on Sunday, October 24, 2010. Each poster board surface accommodates two posters—each poster must be no DON’T MISS the introduction of EMS Connect at the Town larger than 4 feet by 4 feet. Each poster should be displayed Hall Meeting on Sunday. EMS Connect is a new member in the area corresponding with the assigned poster number. benefit with collaboration tools that will enhance your All posters will be on display Sunday through Tuesday. research and teaching, while providing an easy way to keep Poster presenters are requested to present their posters during engaged with EMS activities throughout the year. their assigned poster session only, this is when conference participants will plan to meet you to discuss your work. All In addition to symposia and platform sessions that cover the posters should be removed between 11:30 AM and 12:30 PM broad interests of our membership, there will be a special on Tuesday, October 26, 2010. symposium on Tuesday afternoon to remember a former president of EMS, Sheldon Wolff, and his contributions to science and our Society. On Tuesday evening we will have our Banquet where we will present awards, share some good food with great company, and then dance the night away.

12 Fort Worth, Texas, U.S.A. • October 23–27, 2010

Photography Policy Omni Fort Worth Hotel is a smoke-free property (fines may apply for violations). Photography of scientific presentations is prohibited without advance specific consent of the presenter(s)/author(s). The scientific sessions are located on the second floor. See the Session Chairs are asked to strictly enforce this policy and diagram on page 39. individuals who do not comply will be asked to leave the session. In addition, cameras and recording devices are prohibited in the Exhibit Hall. Ground Transportation Taxi service is available in front of the hotel to transport you First Aid and Security where you need to go. The average fee to the airport is $43. The Omni Fort Worth has equipped each meeting room with a house phone for use in case of emergency. If you need medical Getting around Fort Worth or security assistance pick up the house phone and dial 0; the Climb aboard Molly the Trolley to effortlessly get around hotel operator will connect you to the correct department. Fort Worth! Choose from three Molly routes—the Downtown Get Around, Sundance Lunch Line, and Stockyards Shuttle. Internet Access at the Annual Meeting There is a $1.50 one-way fare for the Stockyards Shuttle. The Downtown Get Around and Sundance Lunch Line routes EMS appreciates how important it is for attendees to stay are both free. Molly stops in front of the Starbucks at Omni connected to daily responsibilities in their home locations Fort Worth Hotel every 15 minutes and runs daily from while attending the meeting. The Omni Fort Worth Hotel 10:00 AM–10:00 PM. Please note that the Sundance Lunch offers free wireless Internet access in sleeping rooms and Line runs every 10 minutes on weekdays from 11:00 AM– common areas to all EMS guests staying at the hotel. 2:00 PM. Ask the Concierge about the world-class museums Please note that this service is not available in the meeting in Fort Worth. rooms or the meeting room foyers. EMS meeting attendees will have access to the EMS Internet Café during registration hours. Parking The Omni Fort Worth Hotel offers valet parking for $20 per Conference Site day. Self parking is available in the city operated garage adjacent to the hotel for $15 per day. Prices are subject to Sculpted from native stone and rich hardwoods and wrapped change. in glass, the Omni Fort Worth Hotel is the newest star in the Lone Star State. Guests will enjoy its casual yet sophisticated style and a personality that’s as gracious and dynamic as Fort Meals Worth itself. Conveniently located in the heart of Fort Worth’s A light breakfast is provided for registrants of the Special exciting downtown, the hotel is within walking distance Interest Group meetings, held Sunday–Wednesday. You are on from the city’s burgeoning cultural centers, restaurants, and your own for lunch and dinner each day with the exception of nightlife. Sunday’s Town Hall meeting which includes a boxed lunch and Tuesday’s Annual Banquet at 7:30 PM which includes Whether you’re searching for a light breakfast, an elegant dinner and dancing to the music of The Genotones, a six- dinner or a guest room meal, you’ll find exactly what you member band with familiar faces. crave at the Omni Fort Worth Hotel. The Hotel features a fine dining Steakhouse, casual three meal restaurant, evening When making a dining decision, the hotel has several wine bar, sports pub, 24-hour room service, and a full-service restaurants. For a complete list please see the hotel restaurant Starbucks. See the hotel restaurant list on page 38. list on page 38. There are also several restaurants within walking distance or a short taxi or trolley ride. Check with the The Omni Fort Worth Hotel features an outdoor rooftop concierge’s desk to learn more. pool, a fully equipped fitness facility, a full-service spa, and a 24-hour business center.

13 Friday st Saturday 41 Annual Meeting of the Environmental Mutagen Society

Agenda

Friday, October 22 In Vivo Genotoxicity Testing 11:00 AM Multi-Tissue, Multi-Endpoint Assessment of Genotoxicity Using an Integrated Study 4:00 PM–6:00 PM Texas Ballroom Foyer Design REGISTRATION Maik J. Schuler, Pfizer Global R & D 11:30 AM Assessment of Micronucleated Erythrocytes: Saturday, October 23 From Mouse to Man Jeffrey Bemis, Litron Laboratories 8:00 AM–6:00 PM Texas Ballroom Foyer 12:00 NOON Boxed Lunch Pick-Up REGISTRATION 9:00 AM–12:00 NOON Sundance 1 8:00 AM–12:15 PM Texas Ballroom F EMS EXECUTIVE BOARD MEETING ADVANCEMENTS IN APPLIED GENETIC TOXICOLOGY WORKSHOP 9:30 AM–4:30 PM Texas Ballroom G Chairpersons: Patricia A. Escobar, Boehringer Ingelheim Pharmaceuticals, Inc. and Krista L. Dobo, Pfizer Global R&D CAREER DEVELOPMENT WORKSHOP Chairpersons: Meredith E. Crosby, Yale University and Organized by the Applied Genetic Toxicology Special Interest Jennifer A. Hobin, Federation of American Societies for Group Experimental Biology (FASEB) Contributing Sponsors: MolTox, Pfizer Inc., and Contributing Sponsors: Federation of American sanofi aventis Societies for Experimental Biology (FASEB) and Research Supported in part by: BioReliance Corporation Corporation for Science Advancement 8:00 AM Introduction 9:30 AM Introduction and Overview Patricia Escobar, Boehringer Ingelheim Meredith E. Crosby, Yale University Pharmaceuticals 9:50 AM Individual Development Plans Developing a Better Understanding of Structure Activity Jennifer A. Hobin, Federation of American Relationships Societies for Experimental Biology 10:30 AM Roundtable Discussion 1: Research, Teaching, 8:10 AM Structure Activity Relationships Administration, and Industry Associated with Genotoxic Impurities of Pharmaceuticals 12:30 PM Lunch on Your Own Michelle Kenyon, Pfizer Inc. 1:30 PM Roundtable Discussion 2: Science Policy, 8:40 AM Evaluating Genotoxicity SAR: Experience Consulting, Journalism, Law, and Marketing from Analysis of Pharmaceutical Impurities 3:30 PM Available Resources and Wrap-Up Joel P. Bercu, Amgen Inc. Alternative In Vitro Models for Genotoxicity Assessment 9:10 AM Novel In Vitro Genotoxicity Assays Using Reconstructed Human Tissues Gladys Ouedraogo-Arras, L’Oreal 9:40 AM Challenges of an Automated In Vitro MN Assay in Mammalian Cell Lines Jing Shi, BioReliance Corporation 10:10 AM Break 10:30 AM Gamma-H2AX As a Biomarker of DNA Damage Induced by Genotoxic Agents Asako J. Nakamura, National Cancer Institute, NIH

14 Fort Worth, Texas, U.S.A. • October 23–27, 2010 Saturday Sunday

12:15 PM–5:00 PM Texas Ballroom F Group 3: Integration Texas Ballroom F of New Technologies: Which GENOTOXICITY OF NANOMATERIALS: REFINING Ones and When Are They Needed? STRATEGIES AND TESTS FOR HAZARD Leaders: Micheline Kirsch-Volders, Vrije IDENTIFICATION WORKSHOP Universiteit Brussel and Masamitsu Honma, Chairpersons: Stefan Pfuhler, The Procter & Gamble National Institute of Health Sciences, Japan Company and Rosalie K. Elespuru, U.S. Food and Drug 3:30 PM Break Administration 3:45 PM Break-Out Group Texas Ballroom F Organized by the ILSI/HESI Nanogenetox Working Group Summaries, General Discussion, and the EMS Regulatory Task Force and Consensus Development Primary Sponsor: The Procter & Gamble Company 12:30 PM–4:00 PM Stockyards 1 Contributing Sponsor: ILSI-HESI IVGT Project Committee EMS COUNCIL MEETING and sanofi aventis 12:15 PM Boxed Lunch Pick-Up 4:30 PM–6:30 PM Texas Ballroom E 12:30 PM Introduction WELCOME RECEPTION AND Stefan Pfuhler, The Procter & Gamble STUDENT and NEW INVESTIGATOR POSTER SESSION Company Supported in part by: Genetic Toxicology Association 12:40 PM Approaches and Caveats to Investigating the Genotoxicity of Nanomaterials Shareen H. Doak, Swansea University Sunday, October 24 1:05 PM Testing for Genotoxic Effects of Nanomaterials In Vitro and In Vivo 7:00 AM–5:00 PM Texas Ballroom Foyer Robert Landsiedel, BASF REGISTRATION 1:30 PM Developing a Coordinated International Research Effort in Nano-Genotoxicology 7:00 AM–8:30 AM breakFAST MEETINGS Tim Singer, Health Canada Applied Genetic Toxicology Sundance 4 1:50 PM Regulatory Issues Related to Genotoxicity Special Interest Group Safety Assessment of Nanomaterials Leaders: Patricia A. Escobar, Boehringer Ingelheim Rosalie K. Elespuru, U.S. Food and Drug Pharmaceuticals and Krista L. Dobo, Pfizer Global R&D Administration Contributing Sponsor: BioReliance Corporation 2:00 PM The Principal Approaches to Genotoxic Hazard Assessment of Nanomaterials in Japan DNA Repair and Mutagenic Sundance 3 Masamitsu Honma, National Institute of Health Mechanisms Special Interest Group Sciences, Japan Leaders: Mats Ljungman, The University of Michigan Medical School and Joann B. Sweasy, Yale University School 2:15 PM–3:30 PM Break-Out Groups: of Medicine Group 1: Standard In Vitro Sundance 1 Transgenic and In Vivo Sundance 2 Assays: Assessment/Strategy Development Mutagenesis Special Interest Group Leaders: Marilyn J. Aardema, Marilyn Leaders: Kathleen A. Hill, The University of Western Aardema Consulting, LLC and Ontario and Mugimane Manjanatha, National Center for Shareen H. Doak, Swansea University Toxicological Research, U.S. FDA Group 2: Standard In Vivo Sundance 2 Assays: Assessment/Strategy 8:30 AM–9:30 AM Texas Ballroom F Development PLENARY LECTURE 1 Leaders: E. Maria Donner, Dupont Haskell GENOMIC DISORDERS: MECHANISMS AND ASSAYS FOR Laboratory and Mugimane Manjanatha, National Center for Toxicological Research, CNV ASSOCIATED WITH HUMAN DISEASE TRAITS U.S. FDA Chairperson: William K. Kaufmann, University of North Carolina, Chapel Hill Lecturer: James R. Lupski, Baylor College of Medicine

15 st Sunday 41 Annual Meeting of the Environmental Mutagen Society

9:45 AM–12:15 PM Texas Ballroom F 10:05 AM S7 Epidemiological Evidence for Increased Cancer in Descendants of Fathers Who SYMPOSIUM 1 Smoke REPLICATION STRESS: ENVIRONMENTAL CAUSES, Patricia A. Buffler, University of California, CELLULAR RESPONSES, AND MUTATIONAL CONSEQUENCES Berkeley Chairpersons: Andrew B. Buermeyer, Oregon State 10:45 AM Break University and Philip C. Hanawalt, Stanford University 11:00 AM S8 Human Primordial Germ Cell Formation Is Diminished by Exposure to Environmental Organized by the DNA Repair and Mutagenic Mechanisms Toxicants Acting through the AHR Signaling Special Interest Group Pathway Supported in part by: Phillip C. Hanawalt Renee Reijo Pera, Stanford University School of Medicine 9:45 AM Introduction 11:45 AM S9 Is Tobacco Smoke a Germ-Cell Mutagen? 9:50 AM S1 Whole Genome Analysis of Structural David M. DeMarini, U.S. Environmental Changes Induced by Environmental Protection Agency Replication Stress Thomas E. Wilson, University of Michigan 12:15 PM Discussion 10:15 AM S2 Replication Fork Protection Proteins 12:30 PM–2:00 PM Timeless and Timeless-Interacting Protein (Tipin) Maintain Genomic Stability LUNCH ON YOUR OWN Stephanie Smith-Roe, University of North Carolina, Chapel Hill 12:45 PM–2:00 PM Texas Ballroom F 10:40 AM Break TOWN HALL MEETING 10:55 AM S3 Defect of the WRN Gene, Linked to (Boxed Lunches Available) Premature Aging in Humans, Protects Mice from Tumor Development EMS Connect: Welcome to the 21st Century Carla Grandori, University of Washington Leader: Ofelia A. Olivero, National Cancer Institute, NIH 11:20 AM S4 Promotion of Genomic Stability by DNA Topoisomerase I by Coordination of Transcription and Replication 2:15 PM–4:30 PM Texas Ballroom G Yves Pommier, National Institutes of Health SYMPOSIUM 3 11:45 AM S5 Replication Fork Indiscretions and Genome DNA INTERSTRAND CROSSLINKS: REPAIR, CELL SIGNALING, Instability AND THERAPEUTIC IMPLICATIONS Sergei M. Mirkin, Tufts University 12:10 PM Discussion Chairpersons: Karen M. Vasquez, University of Texas MD Anderson and Paul S. Miller, Johns Hopkins University Supported in part by: Fanconi Anemia Research Fund 9:45 AM–12:30 PM Texas Ballroom G SYMPOSIUM 2 2:15 PM S10 The Fanconi Anemia Pathway in DNA Interstrand Crosslink Repair IS TOBACCO SMOKE A GERM-CELL MUTAGEN? Alan D’Andrea, Dana-Farber Cancer Institute Chairpersons: Carole Yauk, Health Canada and 2:35 PM S11 Targeting and Processing of Site-Specific Francesco Marchetti, Lawrence Berkeley National DNA Interstrand Crosslinks Laboratory Karen M. Vasquez, University of Texas MD Anderson Organized by the Heritable Mutation and Disease Special Interest Group 2:55 PM S12 Initiation of DNA Interstrand Cross-Link Repair in Mammalian Cells Supported in part by: Anonymous Contributor Paul S. Miller, Johns Hopkins University 9:45 AM S6 Mutagenic Effects of Cigarette Smoke on 3:15 PM Break Sperm in Mice and Humans Carole Yauk, Health Canada

16 Fort Worth, Texas, U.S.A. • October 23–27, 2010 Sunday

3:30 PM S13 Mechanisms of S-Phase Repair of DNA 2:15 PM–4:30 PM Texas Ballroom I Interstrand Crosslinks SYMPOSIUM 5 Randy J. Legerski, University of Texas MD Anderson Cancer Center NEXT GENERATION SEQUENCING TECHNOLOGY AND APPLICATIONS 3:50 PM S14 Assessing the Link between BACH1/FANCJ and MLH1 in the DNA Damage Response Chairpersons: James C. Fuscoe, U.S. Food and Drug Sharon B. Cantor, University of Massachusetts Administration and Brinda Mahadevan, Abbott Laboratories Medical School Organized by the New Technologies Special Interest Group 4:10 PM S15 Role of Homologous Recombination in DNA Interstrand Crosslink Repair 2:15 PM S22 Strategies for the Identification of Disease John M. Hinz, Washington State University Causing Mutations by Complete Genome Sequencing C. Thomas Caskey, The University of Texas 2:15 PM–4:30 PM Texas Ballroom F Health Science Center, Houston SYMPOSIUM 4 2:45 PM S23 Next Generation Technologies: Basics and TELOMERES, AGING, AND HUMAN DISEASE Applications Michael L. Metzker, Baylor College of Chairpersons: Patricia L. Opresko, University of Pittsburgh, Medicine Sequencing Center John P. Murnane, University of California, San Francisco, 3:15 PM Break and Chin-Rang Yang, University of Texas Southwestern, Dallas 3:30 PM S24 Mutation Profiling in Human Cancer Using Next Generation Sequencing 2:15 PM S16 Werner Syndrome Protein and Common David A. Wheeler, Baylor College of Medicine Fragile Site Replication Sequencing Center Kristin A. Eckert, Pennsylvania State University College of Medicine 4:00 PM S25 Large-Scale Human Genome Sequencing for Advanced Disease Studies: Dissecting the 2:35 PM S17 Mechanisms of Telomeric DNA Replication Interplay of Genetics and Environment Woody Wright, University of Texas Radoje Drmanac, Complete Genomics, Inc. Southwestern, Dallas 2:55 PM S18 Telomeric Instability and Double-Strand Breaks 4:30 PM–6:30 PM Texas Ballroom E John P. Murnane, University of California, POSTER SESSION 1 AND EXHIBITS San Francisco Odd Numbered Abstracts Attended 3:15 PM Break Presenting author is underlined. 3:30 PM S19 Human Diseases of Telomerase Dysfunction P1 Use of Bhas-42 Cell Transformation Assay in a Christine K. Garcia, University of Texas Carcinogenicity Screening Format Southwestern, Dallas Pant K, Bruce SW, Sly JE, Klug Laforce ML, Springer SO. BioReliance, Rockville, MD, United States 3:50 PM S20 Klotho and Ageing Related Signaling Pathways in Mice P3 Assessment of Genetic Damage in Oral Sub Mucous Makoto Kuro-O, University of Texas Fibrosis Southwestern, Dallas Varre S, Mundluru HP, Syed SB, PNS M, Penagaluru PR, Akka J. Institute of Genetics, Osmania University, 4:10 PM S21 Quantitative Analysis and Mathematical Hyderabad, AP, India Modeling of Ageing Signaling Network Chin-Rang Yang, University of Texas P5 Functional Analysis of Foxn3 in Mammalian Cells Southwestern, Dallas Stebbins NW, Samaan G, Venkatachalam S. University of Tennessee, Knoxville, TN, United States P7 Insight into Mechanisms of Aristolochic Acid-Induced Carcinogenesis Derived through ACB-PCR Analyses of H- and K-Ras Mutant Fractions in Rat Liver and Kidney Wang Y1, Meng F1, Arlt VM2, Mei N1, Chen T1, Parsons BL1. 1Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR, United States, 2Institute of Cancer Research, Section of Molecular Carcinogenesis, Sutton, United Kingdom

17 st Sunday 41 Annual Meeting of the Environmental Mutagen Society

P9 A Human Intervention Trial for Identification of the P27 Mechanistic Follow-Up Studies for a New Class of Chemopreventive Properties of Isothiocyanates (ITCs) Gyrase Inhibitor Expected to Act As a Clastogenic in Mustard Topoisomerase II Poison Mersch-Sundermann V, Garcia-Käufer M, Prinzhorn J, Heard PL, Gunther WC, Scott A, Spellman RA, Schmitz S, Lamy E. Institute of Environmental Health O’Lone SD, Ackerman J, Kenyon M, Schuler M. Pfizer Sciences, University Medical Centre Freiburg, Freiburg, Worldwide Research & Development, Groton, CT, Germany United States P11 Do Superoxide Dismutase and Catalase Protect Cells P29 Small Molecule Inhibitors of DNA Polymerase Kappa from DNA Damage Induced by Active Arsenicals? Yamanaka K1, Eoff RL2, Egli M2, Dorjsuren D3, Kligerman AD, Tennant AH, Muñiz Ortiz JG. U.S. Jadhav A3, Simeonov A3, Lloyd RS1. 1Oregon Health & Environmental Protection Agency, Research Triangle Park, Science University, Portland, OR, United States, 2Vanderbilt NC, United States University, Nashville, TN, United States, 3NIH Chemical Genomics Center, Bethesda, MD, United States P13 Role of Genetic and Epigenetic Changes in Acrylamide- Induced Lung Carcinogenesis in Mice P31 Thermosensitization of Mouse Mammary Carcinoma Sarfaraz S, Tryndyak VP, Pogribny IP, Beland FA. Using Heat Sensitive Arsenic Trioxide Liposomes National Center for Toxicological Research, Jefferson, AR, Asur R, Bernock L, Jamshidi-Parsian A, Borrelli M, United States Griffin R. University of Arkansas for Medical Sciences, Little Rock, AR, United States P15 Molecular Analysis of Chd2 in Tumor Suppression Samaan G, Venkatachalam S. University of Tennessee, P33 Acute Disruption of Bone Marrow Hematopoietic Knoxville, TN, United States Progenitor Cells by Benzo(a)Pyrene (BP) is Reversed by Processes Dependent on Ah Receptor Activation P17 Maternal Exposure to Household Chemicals and Risk N’jai AU, Larsen M, Czuprynski C, Jefcoate C. University of of Infant Leukemia: A Report from the Children’s Wisconsin, Madison, WI, United States Oncology Group (COG) Slater ME1, Linabery AM1, Spector LG1, Johnson KJ1, P35 Studies on Iron Oxide (Magnetite) Particle Interaction Hilden JM2, Heerema NA3, Ross JA1,4. 1University of with Human A549 Lung Cells In Vitro and Their Toxic Minnesota, Division of Pediatric Epidemiology and Clinical Potential Research, Minneapolis, MN, United States, 2Peyton Manning Mersch-Sundermann V1, Könczöl M1, Goldenberg E2, Children’s Hospital at St. Vincent, Indianapolis, IN, United Ebeling S3, Giére R2, Merfort I3, Rothen-Rutishauser B4, States, 3Ohio State University, Department of Pathology, Gminksi R1. 1Institute of Environmental Health Sciences, Columbus, OH, United States, 4University of Minnesota University Medical Center Freiburg, Freiburg, Germany, Cancer Center, Minneapolis, MN, United States 2Mineralogical-Geochemical Institute, Albert Ludwigs University of Freiburg, Freiburg, Germany, 3Department of P19 Frequency of Reciprocal Translocations in Mothers Pharmaceutical Biology and Biotechnology, Albert Ludwigs and Newborns Living in an Area Polluted with University of Freiburg, Freiburg, Germany, 4Institute of Organochlorine Pesticides Anatomy, University of Bern, Bern, Switzerland Suárez K1, Ortega LE1, Yáñez L2, Camacho R1, Montero RD1. 1Instituto de Investigaciones Biomédicas, P37 Investigating the Mechanism of DNA Damage Induced Universidad Nacional Autónoma de México, Ciudad de by Three Haloacetic Acid Drinking Water Disinfection México, Distrito Federal, Mexico, 2Facultad de Medicina, By-Products Universidad Autónoma de San Luis Potosí, San Luis Potosí, Pals J1,3, Ang J1,3, Attene Ramos M1,3, Marinas B2,3, San Luis Potosí, Mexico Wagner E1,3, Plewa M1,3. 1Dept. of Crop Sciences, University of Illinois Urbana-Champaign, Urbana, IL, United States, P21 Towards Developing Specific Oncomutations As 2Dept. of Civil and Environmental Engineering, University Biomarkers of Cancer Risk of Illinois Urbana-Champaign, Urbana, IL, United States, Myers MB, McKinzie PB, Meng F, Wang Y, Parsons BL. 3Center of Advanced Materials for the Purification of Water NCTR, U.S. FDA, Jefferson, AR, United States with Systems, Urbana, IL, United States P23 Detection of Tamoxifen (TAM)-DNA Adduct Formation P39 Mutagenicity of Three Herbal Products, Pulegone, in Primates and Patients Senna, and Milk Thistle Extract, in the Ames Salmonella Hernandez Ramon EE1, John K1, Woodward RA1,2, Mutagenicity Assay 1 1 Poirier M . NCI/NIH, Bethesda, MD, United States, Swartz CD1, Lentz CA1, Green AS1, Prajapati MH1, 2 NICHD/NIH, Bethesda, MD, United States Recio L1, Witt KL2. 1Integrated Laboratory Systems, 2 P25 Comparison of Benzo[A]Pyrene-Induced DNA Damage Research Triangle Park, NC, United States, National Responsive Pathways in Hepatocytes Derived from Wild- Institute of Environmental Health Sciences, Research Type and Cancer Prone Xpa-/-P53+/- Mice Triangle Park, NC, United States van Kesteren PCE1, Zwart PE1, Pennings JLA1, Pronk TE1, P41 Characterization of EMS and ENU Dose-Response Gottschalk WHR2, Kleinjans JCS2, van Delft JH2, van Steeg Relationships Using the Pig A Mutation Assay 1 1 1 H , Luijten M . Laboratory for Health Protection Research, Dobo KL, Fiedler RD, Gunther WC, Schuler MJ, National Institute for Public Health and the Environment Thifeault CJ, Cammerer Z. Pfizer, Groton, CT, United States (RIVM), Bilthoven, Netherlands, 2Department of Health Risk Analysis and Toxicology, NUTRIM, Maastricht University, Maastricht, Netherlands 18 Fort Worth, Texas, U.S.A. • October 23–27, 2010 Sunday

P43 Influence of Ascorbic Acid and Glutathione on P65 Comprehensive Evaluation of LET-Dependence of Cyclophosphamide and Tamoxifen Induced DNA Chromosome Aberrations after Particle Radiation Damage Exposure In Vivo Sharma S, Naravaneni R, Bhaumick D, Mehta RD. PBR Doppalapudi R, Davis Z, Menda S, Wang A, Bakke J, Laboratories Inc., Edmonton, AB, Canada Chang P. SRI International, Menlo Park, CA, United States P45 Chlorophyllin (CHL) Differentially Modulates Benzo(a) P67 Boronic Acids: A Novel Class of Bacterial Mutagen pyrene-DNA (BP-DNA) Adduct Formation in C57BL/6 O’Donovan MR, Mee CD. AstraZeneca R&D, Alderley Park, Mice Chronically Fed BP and CHL in the Diet Macclesfield, United Kingdom John K1, Churchwell MI2, Beland FA2, Pratt MM1, McMullen G1, Poirier MC1. 1NCI, NIH, Bethesda, MD, P69 Mammalian Cell Cytotoxicity and Genotoxicity United States, 2NCTR, Jefferson, AR, United States of Haloacetaldehyde Drinking Water Disinfection Byproducts P47 In Vitro Experimental Approach for Modulation of Jeong CH1, Richardson SD2, Marinas BJ1, Wagner ED1, Human Susceptibility to Cadmium by Antioxidants Plewa MJ1. 1University of Illinois, Urbana, IL, United States, Gothke SK, Dudley R, Vaglenov A. College of Pharmacy, 2U.S. Environmental Protection Agency, Athens, GA, The University of Findlay, Findlay, OH, United States United States P49 The Protective Effect of Centrum® against Genotoxicity P71 Investigation of Cytotoxic, Genotoxic and Pro-

of Cadmium, Lead, Zinc and H2SO4 Exposed Smelters Inflammatory Effects of Laser Printer Emissions in Vaglenov A1, Dudley R1, Gothke S1, Petkova V2. 1College Human A549 Lung Cells of Pharmacy, University of Findlay, Findlay, OH, United Mersch-Sundermann V, Tang T, Kuhn R, Könczöl M, States, 2Clinic of Toxicology, Medical University of Sofia, Armbruster B, Gründemann C, Gminski R. Institute of Sofia, Bulgaria Environmental Health Sciences, Medical Centre Freiburg, Freiburg, Germany P51 Assessment of Accumulated DNA Damage after 1-Month Exposure to MNU Using the Rat Pig-a, Comet, and P73 Nuclear Bud Formation: A Novel Manifestation of Micronucleus Assays Zidovudine Genotoxicity Custer LL1, Henwood AD1, Gleason CR1, Getman SM1, Dutra A2, Pak E2, Wincovitch S2, John K1, Poirier MC1, Dertinger SD2, Sweder KS1. 1Bristol-Myers Squibb, Olivero OA1. 1National Cancer Institute, Bethesda, MD, Syracuse, NY, United States, 2Litron Laboratories, Rochester, United States, 2National Human Genome Research Institute, NY, United States Bethesda, MD, United States P53 Cellular Responses to Low-Level Alkylation Treatment P75 Genotoxicity of Hydroxyurea in Mice Measured at Doses Sharma VP, Williams KJ. University of Toledo College of Relevant to Pediatric Sickle Cell Anemia Patients Medicine, Toledo, OH, United States Hobbs CA1, Recio L1, Shepard K1, Green A1, Winters J1, Baldetti C1, Streicker M2, Witt KL3. 1Genetic P55 Pig-a Mutation Manifestation in Mice Following Single and Molecular Toxicology Division, Integrated Laboratory and Split Doses of N-Ethyl-N-nitrosourea Systems, Inc., Research Triangle Park, NC, United States, Bhalli JA, Dobrovolsky VN, Heflich RH. National Center for 2Investigative Toxicology Division, Integrated Laboratory Toxicological Research, U.S. Food and Drug Administration, Systems, Inc., Research Triangle Park, NC, United States, Jefferson, AR, United States 3National Toxicology Program (NTP), National Institute of P57 PCB3 Metabolites Induce Spindle Aberrations and Environmental Health Sciences, Research Triangle Park, Reduce Tubulin Polymerization NC, United States Flor S, Ludewig G. University of Iowa, Iowa City, IA, P77 Genotoxicity of Furan in Big Blue Rats United States McDaniel LP, Mittelstaedt RA, Dobrovolsky VN, Doerge P59 Why Are Aneugens Often Clastogenic? Investigating the DR, Ding W, Heflich RH. U.S. FDA National Center for Clastogenic Mechanism of Phenolphthalein (PHT) Toxicological Research, Jefferson, AR, United States Heard P, Spellman R, Rubitski E, Schuler M. Pfizer P79 Adapting the Buccal Micronuclueus Cytome Assay for Worldwide R&D, Groton, CT, United States Use in Wild Birds P61 Differential Induction of Pig-a and Hprt Mutation Shepherd GL, Somers CM. University of Regina, Regina, following Exposure of Rats to Ionizing Radiation SK, Canada Dobrovolsky VN, Shaddock JG, Pearce MG, Heflich RH. P81 Induction and Persistence of Pig-a Mutant Erythrocytes NCTR, U.S. FDA, Jefferson, AR, United States in Sprague Dawley Rats Does Not Correlate with Chromosome Aberrations in Peripheral Blood P63 The Role of Mitochondria in the Radiation-Induced Lymphocytes after Ethylnitrosurea (ENU) Treatment Bystander Effect Roberts DJ, Murli H, Stankowski Jr LF. Covance Rajendran S, Harrison SH, Thomas RA, Tucker JD. Laboratories, Inc., Vienna, VA, United States Wayne State University, Detroit, MI, United States

19 st Sunday 41 Annual Meeting of the Environmental Mutagen Society

P83 Why Do Some Studies Produce Lower Sensitivity Figures P105 Gene Expression Profiling in the Skin of FVB/N Mice for the GADD45a-GFP Assay? Treated with Environmental PAH Mixtures Walmsley R1,2. 1University of Manchester, Manchester, Larkin A, Siddens L, Krueger S, Williams D, Baird W. United Kingdom, 2Gentronix Ltd., Manchester, Oregon State University, Corvallis, OR, United States United Kingdom P107 Evaluation of Genotoxicity of Methyleugenol (MEG) P85 Validation of Two Automated Systems for In Vitro Using Comet Assay and Pathway-Focused Gene Micronucleus Assessment Using 11 Chemicals, with and Expression Profiling in the Liver of F344 Rats without Cytochalasin-B Ding W1, Bishop ME1, Lyn-Cook LE1, Kulkarni R1, Scott A, Munzner J, Rubitski E, Homiski M. Pfizer, Groton, Levy DD2, Aidoo A1, Manjanatha MG1. 1USFDA/National CT, United States Center for Toxicological Research, Jefferson, AR, United States, 2USFDA/Center for Food Safety and Nutrition, P87 Regulatory Safety Testing with the In Vivo Comet Assay: College Park, MD, United States Recommendations for Data Interpretation Vasquez MZ. Helix3 Inc., Morrisville, NC, United States P109 Identification of MicroRNAs That Are Associated with BaP Genotoxicity P89 Miniaturized Flow Cytometric In Vitro Micronucleus Lizarraga D1, Gaj S1, Brauers KJ1, Pothof J2, Scoring Represents an Efficient Tool for Studying Dose- van der Horst GT2, Kleinjans JC1, van Delft JH1. Response Relationships 1Department of Health Risk Analysis and Toxicology, Bemis J, Bryce S, Avlasevich S, Napodano R, Dertinger S. Maastricht University, Maastricht, Netherlands, 2Department Litron Laboratories, Rochester, NY, United States of Cell Biology and Genetics, Erasmus Medical Center, P91 Consistency of Results in Bleomycin Enhancement Rotterdam, Netherlands Assays in Yeast and Mammalian Cells P111 Mapping Arsenic Levels in North Carolina Private Well Hoffmann GR, Tartaglione JP, Wenthen KP. College of the Waters Holy Cross, Worcester, MA, United States Sanders AP1, Messier KP1, Neal J2, Shehee M2, Rudo K2, 1 1 1 P93 Serre ML , Fry RC . University of North Carolina, Chapel Optimization of Culture Conditions to Give a Population 2 of T-Lymphocytes in Exponential Growth Hill, Chapel Hill, NC, United States, North Carolina Department of Health and Human Services, Raleigh, NC, Hayes JE, Doherty AT, O’Donovan MR. AstraZeneca R&D, United States Alderley Park, Macclesfield, United Kingdom P113 European Hot Spot of Air Pollution by PM2.5 and B[a]P: P95 A Comparison of Micronucleus Frequency in Fresh Ostrava, Czech Republic Peripheral Blood Detected by Microscopy and Flow Cytometry Sram RJ, Milcova A, Rossner Jr P, Rossnerova A, Schmuczerova J, Solansky I, Spatova M, Svecova V, Topinka Doherty AT, Hayes JE, O’Donovan MR. AstraZeneca R&D, J. Institute of Experimental Medicine AS CR, Prague, Czech Alderley Park, Macclesfield, United Kingdom Republic P97 Integration of Genotoxicity Testing into Repeat Dose P115 Sodium Azide Shows Reprotoxic Activity in Drosophila Toxicology Studies: What Endpoints and Tissues Should be Evaluated Ramos-Morales P, Munoz-Hernandez A, Hernandez-Bernal BR, Rivas-Martinez H. Universidad Shutsky TJ, Coffing SL, Crammerer Z, Dickinson DD, Nacional Autonoma de Mexico, Mexico, DF, Mexico Engel ME, Fiedler RD, Gunther WC, Munzer JB, O’lone SD, Sanok KE, Schuler MJ, Thiffeault CJ. Pfizer, Groton, CT, P117 Synthetic Intermediate That Is Also a Metabolite, United States Impurity and Degradate: What Are the Appropriate Risk Evaluation Options? P99 Integration of Pig-a, Micronucleus, Chromosome Aberration, and Comet Assay Endpoints in a 28-Day Reddy MV, DeGeorge JD, Ward GJ, Laws GM, Galloway Rodent Toxicity Study with 4-nitroquinoline-1-oxide SM. Merck & Co., Inc., West Point, PA, United States (4NQO) LB1 PTEN Loss Compromises Homologous Recombination Stankowski Jr LF, Roberts DJ, Chen H, Lawlor T, Repair in Astrocytes: Implications for GBM Therapy McKeon M, Murli H, Thakur A, Xu Y. Covance Laboratories, with Temozolomide or PARP Inhibitors Inc., Vienna, VA, United States McEllin BM1, Camacho CV1, Mukherjee B1, Hahm B1, 1 2 1 1 P101 Comparison of Responses in the In Vitro Flow Tomimatsu N , Bachoo RM , Burma S . Department of Radiation Oncology, UT-Southwestern, Dallas, TX, United Cytometric Micronucleus Assay Using CHO and TK6 2 Cells States, Department of Neurology, UT-Southwestern, Dallas, TX, United States Mittelstaedt RA, Shaddock JG, Heflich RH. U.S. FDA, National Center for Toxicological Research, Jefferson, AR, United States P103 Changes in Pancreatic Gene Expression Patterns Due to 2-Aminoanthracene Exposure Gato WE1, Means JC1,2. 1Southern Illinois University, Chemistry and Biochemistry, Carbondale IL, United States, 2College of Science, Carbondale IL, United States

20 Fort Worth, Texas, U.S.A. • October 23–27, 2010 Sunday Monday

LB3 Loss of p15/Ink4b Accompanies Tumorigenesis Triggered by Complex DNA Double-Strand Breaks Monday, October 25 Camacho CV1, Mukherjee B1, McEllin B1, Ding LH1, Hu B1, Habib A2, Xie XJ4, Nirodi C1, Saha D1, Story MD1, 7:00 AM–5:00 PM Texas Ballroom Foyer Balajee A5, Bachoo RM2, Boothman DA1, 3, 4, Burma S1. REGISTRATION 1Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United 2 States, Department of Neurology, University of Texas 7:00 AM–8:30 AM breakFAST MEETINGS Southwestern Medical Center at Dallas, Dallas, TX, United States, 3Department of Pharmacology, University of Texas Epigenetics Sundance 3 Southwestern Medical Center at Dallas, Dallas, TX, United Special Interest Group States, 4Simmons Comprehensive Cancer Center, University Leaders: Janet E. Baulch, University of Maryland, Baltimore of Texas Southwestern Medical Center at Dallas, Dallas, TX, and Catherine B. Klein, New York University School of 5 United States, Center for Radiological Research, Columbia Medicine University, New York, NY, United States New Technologies Sundance 2 LB5 Effect of Oxidative DNA Damage on Transcription Arrest Special Interest Group at G-Quadruplex DNA-Forming Sequences from the Human c-Myc Proto-Oncogene Leaders: Brinda Mahadevan, Abbott Laboratories and Beckett J, Broxson C and Tornaletti S. Department Patricia A. Escobar, Boehringer Ingelheim Pharmaceuticals of Anatomy and Cell Biology, University of Florida, Gainesville, FL, United States 8:30 AM–6:30 PM Texas Ballroom E LB7 The Role of Gene-Environment Interaction in the Phenotypic Variability Seen in SMS and PTLS POSTERS AND EXHIBITS OPEN Heney M1, Gu W1, Lupski JR1,2,3. 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, 8:30 AM–9:30 AM Texas Ballroom F 2 TX, United States, Department of Pediatrics, Baylor College PLENARY LECTURE 2 of Medicine, Houston, TX, United States, 3Texas Children’s Hospital, Houston, TX, United States CHRONIC CELL STRESS, CANCER, AND THE EPIGENOME LB9 Effect of Ionizing Radiation on K-ras Codon 12 Point Chairperson: Janet E. Baulch, University of Maryland, Mutations in Lung and Liver of the F344 Rat Baltimore McKinzie PB, Dobrovolsky VN, Shaddock JG, Pearce MG, Heflich RH. National Center for Toxicological Research, Lecturer: Stephen B. Baylin, The Johns Hopkins University U.S. FDA, Jefferson, AR, United States School of Medicine LB11 Use of γ-H2AX and Micronuclei Formation to Evaluate Genotoxicity in Cultured Human Skin Cells Following Sulfur Mustard Exposure 9:45 AM–12:15 PM Texas Ballroom G Miller AL, Gross CL, Nealley EW, Clark OE, Waraich NK, SYMPOSIUM 6 Rodgers KL, Smith WJ. Research Division, United States Army Medical Research Institute of Chemical Defense, RNA SILENCING: MECHANISM, BIOLOGY AND RESPONSES Aberdeen Proving Ground, MD, United States TO ENVIRONMENTAL STRESS Chairpersons: Igor P. Pogribny, National Center for 6:30 PM–8:30 PM cOMMITTEE MEETINGS Toxicological Research, U.S. FDA and Olga Kovalchuk, 2011 Program Committee Fort Worth 1 University of Lethbridge Meeting (First Meeting) Contributing Sponsor: Elsevier Awards and Honors Committee Fort Worth 2 Underlined author indicates presenter. Web Site Committee Fort Worth 3 9:45 AM S26 MicroRNAome Changes in Radiation- Induced Genome Instability Olga Kovalchuk, University of Lethbridge 10:15 AM S27 Epimutation Induction by Environmental Factors, Such As H. pylori Infection and Smoking Toshikazu Ushijima, National Cancer Centre Research Institute

21 st Monday 41 Annual Meeting of the Environmental Mutagen Society

10:45 AM S28 Small Non-Coding RNAs for Medical 11:15 AM S35 Effect of In Utero Gene-Environment Practice Interactions on Mental Development George A. Calin, University of Texas, MD Frederica P. Perera, Columbia University Anderson Cancer Center School of Public Health 11:15 AM S29 piRNAs and Transposable Elements in the 11:40 AM S36 Trans-Placental Exposures and Children’s Germ-Line Mental and Physical Health Alex Bortvin, Carnegie Institution Nina T. Holland, University of California, Berkeley 11:45 AM S30 MicroRNA Expression during Aflatoxin

B1-Induced Hepatocarcinogenesis in HCV Transgenic and C57BL/6J Mice 12:15 PM–1:00 PM Texas Ballroom F Volodymyr Tryndyak, National Center for Toxicological Research, U.S. FDA BUSINESS MEETING 12:00 NOON S31 Epigenetic Changes in C57BL/6J Mice Induced by Short-Term Exposure to 1:00 PM–2:00 PM Stockyards 1 1,3-Butadiene by Inhalation STUDENT AND NEW INVESTIGATOR BRUNCH Scherhag A1,2, Sorrentino J3, Pogribny I1, Rusyn I3, Koturbash I1. 1National Center for Toxicological Research, Food and Drug 1:00 PM–2:15 PM Administration, Jefferson, AR, United States, LUNCH ON YOUR OWN 2University of Kaiserslautern, Kaiserslautern, Rheinland-Pfalz, Germany, 3University of North Carolina, Chapel Hill, NC, United States 2:15 PM–4:30 PM Texas Ballroom F SYMPOSIUM 8 9:45 AM–12:15 PM Texas Ballroom F MITOCHONDRIA MUTAGENESIS AND DISEASE SYMPOSIUM 7 Chairpersons: Jason H. Bielas, The Fred Hutchinson Cancer COGNITIVE CONSEQUENCES OF FETAL AND EARLY Research Center and P.J. Brooks, National Institute on POSTNATAL EXPOSURE TO ENVIRONMENTAL Alcohol Abuse and Alcoholism CONTAMINANTS Primary Sponsor: The Ellison Medical Foundation Chairpersons: Radim J. Sram, Institute of Experimental No. AG-CW-0317-10 Medicine and Miriam C. Poirier, National Cancer Institute, NIH Underlined author indicates presenter. Organized by the Molecular Epidemiology Special Interest 2:15 PM S37 Proteins of Nucleotide and Base Excision Repair Pathways Interact in Mitochondria Group to Protect from Loss of Subcutaneous Fat: Contributing Sponsor: Office of Research in Women’s A Hallmark of Aging Health, NIH Mark Berneberg, Eberhard Karls Universität 2:35 PM S38 Mitochondrial ROS and mtDNA Mutations: 9:45 AM S32 Neurobehavioral Consequences of Prenatal A Central Role in Cardiac Health and Aging? Exposure to Phthalates in a Multiethnic Cohort Peter S. Rabinovitch, University of Washington Stephanie M. Engel, The Mount Sinai School of 2:55 PM S39 Mitochondrial DNA Damage Initiates a Medicine Cell Cycle Arrest by a Chk2-Associated Mechanism in Mammalian Cells 10:10 AM S33 Impact of Air Pollutants in the Czech Republic on Children’s Health Outcomes Susan P. LeDoux, University of South Alabama Radim J. Sram, Institute of Experimental 3:15 PM Break Medicine 3:30 PM S40 Mitochondrial Fusion is Required for mtDNA 10:35 AM S34 The Effect of Maternal Smoking during Stability and Tolerance of mtDNA Mutations Pregnancy on Intellectual Disabilities among Marc Vermulst, University of North Carolina 8-Year Old Children Joyce S. Nicholas, Medical University of South 3:50 PM S41 The Mechanism and Clinical Utility of Carolina, Charleston Somatic Mitochondrial Mutagenesis in Cancer 11:00 AM Break Jason H. Bielas, The Fred Hutchinson Cancer Research Center

22 Fort Worth, Texas, U.S.A. • October 23–27, 2010 Monday

4:10 PM S42 Evidence That mtDNA Depletion but Not 2:15 PM–4:30 PM Texas Ballroom I Point Mutations or Deletions Causes DNA PLATFORM SESSION 1 Polymerase Gamma-Related Mitochondrial Diseases DNA REPAIR Stumpf JD1, Bailey CM2, Spell D1, Stillwagon M1, Anderson KS2, Copeland Chairpersons: Mats Ljungman, University of Michigan and WC1. 1National Institue of Environmental Christine Canman, University of Michigan Health Sciences, Research Triangle Park, NC, United States, 2Yale University, Department of Organized by the DNA Repair and Mutagenic Mechanisms Pharmacology, New Haven, CT, United States Special Interest Group Presenting author is underlined. 2:15 PM–4:30 PM Texas Ballroom G 2:15 PM 1 REV1 and DNA Polymerase ζ Facilitate SYMPOSIUM 9 Homologous Recombination Repair Canman CE. Department of Pharmacology, ADVANCES AND USE OF TOXICOGENOMICS IN RISK University of Michigan, Ann Arbor, MI, ASSESSMENT United States Chairpersons: Nagu Keshava, U.S. Environmental Protection 2:40 PM 2 Structural and Functional Insights into the Agency and Michael D. Waters, Integrated Laboratory Non-Homologous End-Joining Pathway Systems, Inc. Lees-Miller SP. Department of Biochemistry and Molecular Biology, University of Calgary, Organized by the Risk Assessment Special Interest Group Calgary, AB, Canada Underlined author indicates presenter. 3:05 PM 3 A Member of NER Proteins XPF Is Involved in DNA DSB Repair by MMEJ in 2:15 PM Introduction: The State of the Science— Mammalian Cells From Genomics to Risk Assessment Scuric Z, Schiestl RH. UCLA, Los Angeles, CA, Nagu Keshava, U.S. Environmental Protection United States Agency 3:20 PM Break 2:25 PM S43 Predicting Carcinogenicity and Mode of Action Using Conventional and 3:35 PM 4 Epigenetic Drugs As Modifiers of NHEJ Toxicogenomics Approaches Repair Michael D. Waters, Integrated Laboratory Robert C, Gojo I, Rassool F. University of Systems, Inc. Maryland, Baltimore, Baltimore, MD, United States 2:50 PM S44 Systems Biology of Human Benzene Exposure 4:00 PM 5 A Cross-Species Approach for the Discovery Luoping Zhang, University of California, of Genetic Interactions in the DNA Damage Berkeley Response 3:15 PM Break Piening BD, Huang D, Hsu H-M, Wang S, Murakami-Sekimata A, Wang P, Paulovich AG. 3:30 PM S45 Genotoxicity and Gene Expression Profiles Fred Hutchinson Cancer Research Center, of Organic Extracts from the Air Particles Seattle, WA, United States Measured in Human Cell Lines Topinka J, Hanzalova K, Libalova H, 4:15 PM 6 Role of Nucleotide Excision Repair (NER) in Milcova A, Schmuczerova J, Sram RJ. Institute Manifestation of Zidovudine (AZT)-Induced of Experimental Medicine AS CR, v.v.i., Prague, Aneuploidy and Centrosomal Dysregulation Czech Republic Momot D, Nostrand TA, Ward Y, John K, Poirier MC, Olivero OA. National Cancer Institute, 3:50 PM S46 Systems Biology Approach for Understanding Bethesda, MD, United States MOA, Dose-Response and Susceptibility of Environmental Chemicals Steve Simmons, U.S. Environmental Protection Agency 4:10 PM S47 Advancing the Next Generation of Risk Assessment Ila Cote, U.S. Environmental Protection Agency

23 st Monday 41 Annual Meeting of the Environmental Mutagen Society

4:30 PM–6:30 PM Texas Ballroom E P24 A Novel XPD Mutation in a Compound Heterozygote Patient with Mild Sun Sensitivity POSTER SESSION 2 AND EXHIBITS Falik-Zaccai TC2,3, Erel-Segal R2, Horev-Yakir L5, Even Numbered Abstracts Attended Biterman-Deutsch O2, Zohar K2, Limor K2, Slor H4, Presenting author is underlined. Spivak G1, Hanawalt PC1. 1Stanford University, Stanford, CA, United States, 2Western Galilee Hospital, Naharia, P2 TAT-Mediated Delivery of a DNA Repair Enzyme to Israel, 3Technion, Israeli Institute of Technology, Haifa, Human Skin Cells Rapidly Catalyzes Repair of UV- Israel, 4Tel Aviv University, Tel Aviv, Israel, 5Hadassah Induced DNA Damage Medical Center, Jerusalem, Israel Johnson JL, Kumari A, Lowell BC, Earley L, Ryabinina OP, Lloyd RS, McCullough AK. Oregon Health P26 Loss of Breast Cancer Susceptibility Protein 1 (BRCA1) and Science University, Portland, OR, United States is Associated with an Increase in Error-Prone DNA Repair P4 FANCD2 Deficiency in Human Hematopoietic Cells Thompson EG, Dixon K. University of Arizona, Tucson, AZ, Increases Sensitivity to Formadehyde Toxicity United States Ren X, Ji Z, Yuh J, Tang M, Bersonda J, Smith M, Zhang L. University of California, Berkeley, Berkely, CA, P28 The Potential Role of DNA Polymerase ϴ (POLQ) in United States DNA Damage Processing Yousefzadeh MJ1,2, Takata K-I1, Wood RD1,2. 1University of P6 High Levels of Transcription Stimulate A-to-C Texas M.D. Anderson Cancer Center, Science Park Research Transversions in AP Endonuclease I Deficient Yeast Division, Smithville, TX, United States, 2University of Begins KJ, Lippert MJ. Saint Michael’s College, Colchester, Texas Graduate School of Biomedical Sciences at Houston, VT, United States Houston, TX, United States P8 The Effect of Elevated Transcription Level on the P30 DNA Glycosylase Expression and Modulation of PARP Distribution of Gross Chromosomal Rearrangement Inhibitor Response Breakpoints Svilar D1,2, Tang J-B1, Trivedi R1,2, Wang X-H1, Goellner E1,2, Palermo MP, Lippert MJ. Saint Michael’s College, Brown A1, Sobol R1,2. 1Hillman Cancer Center, University Colchester, VT, United States of Pittsburgh Cancer Institute, Pittsburgh, PA, United States, 2Department of Pharmacology & Chemical Biology, P10 The Role of Werner Syndrome Protein in Protecting against Cr(VI)-Induced Telomere Associated Instability University of Pittsburgh School of Medicine, Pittsburgh, PA, and Mutagenesis United States Liu F, Knickelbein K, Strutt S, Opresko P. University of P32 Mitochondrial Fusion and Autophagy Aid in Removal of Pittsburgh, Pittsburgh, PA, United States Helix-Distorting Mitochondrial DNA Damage Bess AS, Crocker TL, Meyer JN. Duke University, Durham, P12 Bloom Syndrome Protein and Rad51 Promote Genomic Stability NC, United States Bergeron KL, Murphy EL, Almeida KH. Rhode Island P34 Disruption of Human Mitochondrial DNA Polymerase College, Providence, RI, United States γ Replication by the Endogenous Aldehyde Adduct of

DNA, M1dG P14 Identification of Escherichia coli MUG As a Robust 1 2 3 1 Xanthine DNA Glycosylase Cline SD , Marnett LJ , Copeland WC . Mercer University School of Medicine, Macon, GA, United States, 2Vanderbilt Lee H-W, Brice AR, Wright CB, Dominy BN, Cao W. University School of Medicine, Nashville, TN, United States, Clemson University, Clemson, SC, United States 3National Institute of Environmental Health Sciences, P16 DNA Damage and Repair Kinetics Study of Research Triangle Park, NC, United States Monohaloacetonitriles in Mammalian Cells P36 Artemis Over-Expression Confers Radioresistance to Komaki Y, Pals J, Wagner ED, Marinas BJ, Plewa MJ. Both High and Low LET Exposures University of Illinois, Urbana, IL, United States Sridharan D1, Whalen M1, Almendrala D1, Cucinotta F2, P18 Bypass of N2-Deoxyguanosine Interstrand Cross-Links Yannone SM1, Pluth JM1. 1Lawrence Berkeley National by Human DNA Polymerase Eta Laboratory, Berkeley, CA, United States, 2NASA, Lyndon B. Minko IG, Klug AR, Harbut MB, Lloyd RS. Oregon Health & Johnson Space Center, Houston, TX, United States Science University, Portland, OR, United States P38 Double-Strand Break Repair in DNA Structure-Induced P20 Can the Mycobacterium Tuberculosis Ku Protein Genetic Instability Sensitize Mammalian Cells to DNA Damage? Wang G1, Kha DT1, Natrajan N1, Harrison L2, Vasquez KM1. 1 Castore R1, Hughes C1, DeBeaux A1, Tatchell K1, Zeng C2, Department of Carcinogenesis, University of Texas M.D. Wang S-Y2, Chen D2, Harrison L1. 1LSU Health Sciences Anderson Cancer Center, Science Park, Research Division, 2 Center, Shreveport, LA, United States, 2UT Southwestern, Smithville, TX, United States, Department of Molecular Dallas, TX, United States and Cellular Physiology, Louisiana Health Sciences Center, Shreveport, LA, United States P22 Y-Family DNA Polymerases: Heroes or Villains? P40 Validation of the In Vitro Comet Assay to Screen Drug Baptiste BA, Eckert KA. Penn State College of Medicine, Candidates with Potential to Inhibit DNA Repair Hershey, PA, United States Sawant SG. Amgen Inc., Thousand Oaks, CA, United States 24 Fort Worth, Texas, U.S.A. • October 23–27, 2010 Monday

P42 Reduced Rad51 Foci Formation in Rad51D Null CHO P58 Association between Estrogen Receptor: A Gene & Cells during Disruption of DNA Replication is Uncoupled Metallothionein-1 Gene Polymorphisms in Obese Type 2 from Cell Killing Diabetic Women of Indian Population Urbin SS1, Hinz JM2, Thompson LH1. 1Lawrence Livermore Ganasyam SR, Murthy S, Talluri B. Osmania University, National Laboratory, Livermore, CA, United States, Hyderabad, AP, India 2Washington State University, Pullman, WA, United States P60 A Rare Case of Short-Chain Acyl Co-A Dehydrogenase P44 Multiple Roles of ATR and ATM in a Model Replication- Deficiency: The Apparent Rarity of the Disorder Results Stressed Stem-Cell-Niche System: Rescue of Blocked in under Diagnosis in the Developing Countries Forks vs. Activation of Programmed Death Ganasyam SR, Madireddy S. Osmania University, Curtis MB, Tominey CM, Wilcox BW, Hays JB. Oregon State Hyderabad, AP, India University, Corvallis, OR, United States P62 Human Genomic Disorders: Single Events or P46 REV3L: A Specialized Mammalian DNA Polymerase Destabilized Meiosis? Critical for Cell Survival Manchester DK. University of Colorado Denver School Lange SS, Wittschieben JP, Wood RD. Department of of Medicine, The Children’s Hospital, Aurora, CO, Molecular Carcinogenesis, University of Texas M.D. United States Anderson Cancer Center, Science Park-Research Division, Smithville, TX, United States P64 Genetic Variation at the Human Tissue-Type Plasminogen Activator (tPA) Locus and the Risk of P48 Non-B DNA-Forming Sequences and WRN Deficiency Stroke Independently Increase the Frequency of Spontaneous Munshi A, Jyothy A. Institute of Genetics and Hospital for Base Substitution in Human Cells Genetic Diseases, OU, Hyderabad, AP, India Bacolla A4, Wang G4, Jain A4, Chuzhanova NA1, Cooper DN2, Bohr VA3, Vasquez KM1. 1School of Science P66 Role of a Single Nucleotide Polymorphism in the MMP 9 and Technology, Nottingham Trent University, Nottingham, Promoter and Serum MMP 9 Levels in the Development United Kingdom, 2Institute of Medical Genetics, School of Gastric Cancer Disease 1 1 1 1 of Medicine, Cardiff University, Cardiff, United Kingdom, Venkateshwari A , Bhayal A , Srimanjari K , Nallari P , 2 1 1 3Laboratory of Molecular Gerontology, National Institute Vidyasugar A , Jyothy A . Institute of Genetics and Hospital on Aging, National Institutes of Health, Baltimore, MD, for Genetic Diseases, Osmania University, Hyderabad, AP, 2 United States, 4Department of Carcinogenesis, Science Park, India, Gandhi Hospital, Secunderabad, AP, India Research Division, The University of Texas, M.D. Anderson P68 Genotoxicity of X-Ray Contrast Agent-Contaminated Cancer Center, Smithville, TX, United States Water after Disinfection P50 Translesion Synthesis Past an Acrolein-Derived DNA Osiol JL1, Duirk JS2, Ternes TA3, Richardson SD2, Adduct, Gamma-Hydroxypropano-Deoxyguanosine, by Wagner ED1, Plewa MJ1. 1University of Illinois, Urbana, Human Mitochondrial DNA Polymerase Gamma IL, United States, 2U.S. EPA, Athens, GA, United States, 3 Kasiviswanathan R1, Minko IG2, Lloyd RS2, Copeland WC1. Federal Inst. Hydrology, Koblenz, Germany 1 Laboratory of Molecular Genetics, National Institute of P70 Nitrosamines Are Drinking Water Disinfection Environmental Health Sciences, Research Triangle Park, 2 Byproducts: Comparison of Genotoxicity in Bacterial NC, United States, Center for Research on Occupational and Mammalian Cells and Environmental Toxicology, Oregon Health & Science Wagner ED, Hsu K, Lagunas A, Plewa MJ. University of University, Portland, OR, United States Illinois, Urbana, IL, United States P52 DNA Repair Proteins Influence DNA Structure-Induced P72 AZT Is Predominately Clastogenic, Not Mutagenic. Genomic Instability Results from a Seven Day Study in Rats Zhao J1, Wang G1, Jain A1, Freudenreich CH2, Vasquez KM1. Zeller A1, Struwe M1, Koenig J1, Festag M1, Dertinger SD2, 1Department of Carcinogenesis, University of Texas MD Gocke E1. 1F. Hoffmann-La Roche Ltd., Basel, Switzerland, Anderson Cancer Center, Science Park Research Division, 2Litron Laboratories, Rochester, NY, United States Smithville, TX, United States, 2Department of Biology, Tufts University, Medford, MA, United States P74 Polymorphism Studies in CYP1A1, GSTMI, GSTTI Genes in Traffic Police Exposed to Vehicular Exhaust P54 Regulation of DNA Damage Responses by Chromodomain Helicase DNA Binding Protein 2 Mundluru HP, Badabagni SP, Peddireddy V, Varre S, Kadali K, Penagaluru PR, Akka J. Institute of Genetics, Venkatachalam S, Rajagopalan S, Samaan G. University of Osmania University, Hyderabad, AP, India Tennessee, Knoxville, TN, United States P76 Genotoxic Damage in Oral Epithelial Cells Induced by P56 Genetic Variations in Alpha Tropomyosin Gene in HCM Fluoride in Drinking-Water on Students of Tula Mexico and DCM Patients from India Vaquez-Alvarado P1, Prieto-Garcia F2, Gordillo-Martínez Nallari P1, Rani DS2, Calambur N3, Thangaraj K2. A2, Coronel-Olivarez C2, Ortiz-Espisnosa RM1, Hernández- 1Department of Genetics, Osmania University, Hyderabad, Ceruelos A1. 1Instituto de Ciencias de la Salud Universidad India, 2Centre For Cellular and Molecular Biology, Autónoma del Estado de Hidalgo, Pachuca, HG, Mexico, Hyderabad, India, 3Care Hospitals, Hyderabad, India 2Instituto de Ciencias Básicas e Ingenieria, Pachuca, HG, Mexico

25 st Monday 41 Annual Meeting of the Environmental Mutagen Society

P78 Micronucleus Induction by Ochratoxin A in CHO and P92 The Development Program Abstract of Tradescantia TK6 Cells Paludosa Micronucleus Research Restarted by Guangxi Ali R1,2, Mittelstaedt RA1, Shaddock JG1, Bhalli JA1, Institute of Botany, Academia Sinica Heflich RH1. 1National Center for Toxicological Research Mao SH, Tang WX, Luo WH, Ding L, Chen RH. Guangxi (NCTR), U.S. Food and Drug Administration (U.S. Institute of Botany, GuiLin, China FDA), Jefferson, AR, United States, 2National Institute for Biotechnology and Genetic Engineering (NIBGE), P94 Automatic Analysis of the Micronucleus Test in Primary Faisalabad, Pakistan Human Lymphocytes Using the ROBIAS System Frieauff W, Martus H-J, Suter W, Elhajouji A. Preclinical P80 Evaluation of the Mutagenic/Non-Mutagenic Pair Safety, NIBR, Novartis Pharma AG, Basel, Switzerland Benzo[a]pyrene/Pyrene in the Pig-a Mutation and Micronucleated Reticulocyte Assays P96 Evaluation of the Mouse Lymphoma Mutation Assay Torous DK1, MacGregor JT2, Phonethepswath S1, Weller P1, (MLA) Data of the U.S. National Toxicology Program Bemis JC1, Dertinger SD1. 1Litron Laboratories, Rochester, (NTP) Using International Workshop on Genotoxicity NY, United States, 2Toxicology Consulting Services, Arnold, Tests (IWGT) Criteria 1 1 2 1 MD, United States Schisler MR , Gollapudi BB , Moore MM . The Dow Chemical Company, Midland, MI, United States, P82 Integrated Assessment of 7,12-dimethylbenz(a) 2National Center for Toxicological Research, Jefferson, AR, anthracene (DMBA) Induced Genotoxicity by the Pig-a, United States Micronucleus and Comet Assays Following a 28-Day Repeated Treatment P98 Utility of the In Vitro Mutagenicity Assay in Muta™ Shi J1, Krsmanovic L1, Paranjpe M1, Bruce S1, Mouse FE1 Cells for Regulatory Assessment of Kelley T1, Springer S1, Sly J1, Klug M1, Arevalo M1, Genotoxicity Atta-Safoh S1, Debelie F1, Sareen P1, Dertinger S1,2. Long AS, White PA. Mechanistic Studies Division, 1BioReliance Corporation, Rockville, MD, United States, Environmental and Radiation Health Sciences Directorate, 2Litron Laboratories, Rochester, NY, United States HECSB, Health Canada, Ottawa, ON, Canada P84 Searching for New Markers of Instability in the Germline P100 Evaluation of Pig-a Gene Mutation Data: A Post-Hoc of Mice: Are Simple Tandem Repeats (STR) the Needle in Analysis of Sample Size As Related to the Variability, the Haystack? Statistical Significance, and Biological Relevance of Beal MA, Shepherd GL, Somers C. University of Regina, Observed Responses Regina, SK, Canada Stankowski Jr LF, Roberts DJ, Chen H, Thakur A. Covance Laboratories, Inc., Vienna, VA, United States P86 Pig-a Mutation Assay: Evaluation of Inter-laboratory Transferability and Reproducibility P102 Measuring DNA Damage in 3D Human Skin Models Dertinger SD1, Phonethepswath S1, Weller P1, Using the Comet Assay 1 2 3 2 1 Stankowski Jr LF2, Roberts DJ2, Shi J3, Krsmanovic L3, Downs T , Reus A , Reisinger K , Krul Cyrille , Pfuhler S . 1 Vohr H-W4, Custer L5, Gleason C5, Henwood A5, Sweder Procter & Gamble Co., Cincinnati, OH, United States, 2 3 K5, Giddings A6, Lynch AM6, Gunther WC7, Thiffeault CJ7, TNO Quality of Life, Zeist, Netherlands, Henkel AG & Co Shutsky TJ7, Fiedler RD7, Bhalli JA8, Heflich RH8. 1Litron KgaA, Dusseldorf, Germany 2 Laboratories, Rochester, NY, United States, Covance P104 Altered Expression Levels of Mitochondria-Related 3 Laboratories, Vienna, VA, United States, BioReliance, Genes in Acrylamide- and Glycidamide-Treated 4 Rockville, MD, United States, Bayer Schering Pharma Transgenic Big Blue Mice 5 AG, Wuppertal, Germany, Bristol-Myers Squibb, Syracuse, 1 2 1 1 1 6 Desai VG , Lee T , Moland CL , Branham WS , Fuscoe JC , NY, United States, GlaxoSmithKline, Ware, Hertfordshire, Ali AA3, Collins JB4, Shelton SD5, Manjanatha MG5. 1Center United Kingdom, 7Pfizer Global R&D, Groton, CT, United 8 for Functional Genomics, Division of Systems Biology, States, U.S. FDA/NCTR, Jefferson, AR, United States National Center for Toxicological Research (NCTR), U.S. P88 Extended Recovery Periods Improve the Sensitivity of Food and Drug Administration (U.S. FDA), Jefferson, AR, the OECD TG487 Compliant In Vitro Micronucleus United States, 2Department of Information and Mathematics, Assay in TK-6 Cells Korea University, Jochiwon, Chungnam, Republic of Korea, 3 Scott AB, Dickinson DA, Homiski ML, Munzner JB, Toxicology Pathology Association, Jefferson, AR, United 4 O’Lone SD, Sanok KE, Schuler MJ, Sherman JR, Sobol Z, States, Office of Scientific Coordination, NCTR, U.S. FDA, 5 Spellman RA. Pfizer, Inc., Groton, CT, United States Jefferson, AR, United States, Division of Genetic Toxicology, NCTR, U.S. FDA, Jefferson, AR, United States P90 Sensitivity and Specificity of the In Vivo Rodent Micronucleus Assay towards the Detection of Rodent P106 Formaldehyde Exposure Alters MicroRNA Expression Carcinogens: An Updated Analysis of National Profiles in Human Lung Cells Toxicology Program Data Rager JE, Smeester L, Jaspers I, Sexton KG, Fry RC. Levy DD1, McDaniel LP2, Witt KL3. 1U.S. FDA Center for University of North Carolina, Chapel Hill, NC, United States Food Safety and Applied Nutrition, College Park, MD, United States, 2U.S. FDA National Center for Toxicological Research, Jefferson, AR, United States, 3U.S. NIH National Toxicology Program, Research Triangle Park, NC, United States 26 Fort Worth, Texas, U.S.A. • October 23–27, 2010 Monday

P108 In Vitro Evaluation of Carcinogenic and Genotoxic LB8 Effect of p53 Genotype on the Gene Expression Profiles Properties of Chemicals Using a Transcriptomics-Based of the Heart, Liver and Testes of C57BL/6 Mice Approach Petibone DM1, Kulkarni R1, Chen JJ2, Chang C-W2, Morris Magkoufopoulou C, Jennen DGJ, Claessen SMH, SM1. 1Division of Genetic and Molecular Toxicology, Kleinjans JCS, van Delft JHM. Department of Health Risk National Center for Toxicological Research, U.S. FDA, Analysis and Toxicology, Netherlands Toxicogenomics Jefferson, AR, Untied States, 2Division of Personalized Center, Maastricht University, Maastricht, Netherlands Medicine and Nutrition, National Center for Toxicological Research, U.S. FDA, Jefferson, AR, United States P110 Adaptations of the In Vitro Cytochalasin-B Micronucleus Assay for Nanoparticle Testing LB10 Toward a Molecular Equivalent Dose: Use of the Medaka Gonzalez L1, Sanderson BJS2, Kirsch-Volders M1. 1Vrije Model in Comparative Risk Assessment Universiteit Brussel, Brussels, Belgium, 2Flinders University, Hobbie KR1, DeAngelo AB2, King LC2, Winn RN3, Law JM1. Adelaide, Australia 1Comparative Biomedical Sciences Program and Center for Comparative Medicine and Translational Research, CVM, P112 Identifying Concomitant Metals in Dust, Urine, and NCSU, Raleigh, NC, United States, 2NHEERL, USEPA, Fingernails from Children in Detroit, Michigan Research Triangle Park, NC, United States, 3Aquatic 1 2 2 2 Sanders AP , Gallagher JE , McGee J , Rhoney S , Biotechnology and Environmental Laboratory, UG, Athens, 2 1 1 Hudgens E , Fry RC . University of North Carolina, GA, United States Chapel Hill, Chapel Hill, NC, United States, 2U.S. Environmental Protection Agency, Research Triangle Park, NC, United States 6:30 PM–8:30 PM cOMMITTEE MEETINGS P114 Lessons Learned from Late Mutagenicity Testing of Lead Education, Student and Fort Worth 1 Pharmaceutical Series New Investigator Affairs Committee Diehl M, Sonders P, Vasudevan A, Nicolette J. Abbott Laboratories, Abbott Park, IL, United States Public Relations and Fort Worth 2 Communications Committee P116 Analysis of Genetox Structural Alerts Patlewicz G2, Myatt G1. 1Leadscope, Columbus, OH, Membership and Professional Sundance 2 United States, 2DuPont, Newark, DE, United States Development Committee and Special Interest Group Leaders LB2 Protection by Flavonoids on Food Mutagen-Induced DNA Damage in Peripheral Blood Lymphocytes from Colon Cancer Patients Compared to Healthy Controls Kurzawa-Zegota M, Najafzadeh M, Baumgartner A, Anderson D. School of Life Sciences, Genetic and Reproductive Toxicology Group, Division of Biomedical Sciences, University of Bradford, Bradford, United Kingdom LB4 Aryl Boronic Acids: Potentially Mutagenic Synthetic Intermediates Kenyon M1, Cheung J1, Ellis P2, Ackerman J1, Caron S1, Dobo K1. 1Pfizer Global Research and Development, Groton, CT, United States, 2Pfizer Ltd, Sandwich, Kent, United Kingdom LB6 Genotoxins Induce Binucleated Cells without Addition of Cytochalasin B and Increase the Incidence of Micronuclei in Them Chocian K1, Doherty AT 2, Molloy J2, Clatworthy M3, Jenkins G3, O’Donovan M2. 1Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom, 2Genetic Toxicology, AstraZeneca, Alderley Park, United Kingdom, 3Institute of Life Sciences, Swansea School of Medicine, Swansea University, United Kingdom

27 st Tuesday 41 Annual Meeting of the Environmental Mutagen Society

11:15 AM S51 The Role of 8-oxoG in Eliciting an Tuesday, October 26 Inflammatory Response Istvan Boldogh, University of Texas Medical 7:00 AM–5:00 PM Texas Ballroom Foyer Branch REGISTRATION 11:40 AM S52 Chemopreventive Efficacy of Agents that Interact with the Antioxidant Response Element and Agents that Induce the Ah 7:00 AM–8:30 AM breakFAST MEETINGS Receptor Executive Board Meeting Sundance 4 Ronald A. Lubet, National Cancer Institute, NIH Heritable Mutation and Sundance 3 Disease Special Interest Group 12:05 PM Discussion Leaders: Carole Yauk, Health Canada and Francesco Marchetti, Lawrence Berkeley National 9:45 AM–12:15 PM Texas Ballroom G Laboratory SYMPOSIUM 11 Risk Assessment Sundance 2 BIOMARKERS OF EXPOSURE Special Interest Group Leaders: David A. Eastmond, University of California, Chairpersons: Matthew A. Coleman, Lawrence Livermore Riverside and Nagu Keshava, U.S. Environmental Protection National Laboratory and Paul T. Henderson, University of Agency California, Davis Underlined author indicates presenter. 8:30 AM–11:30 AM Texas Ballroom E 9:45 AM S53 Models and Confounding Factors in Biomarker Development POSTERS AND EXHIBITS OPEN Matthew A. Coleman, Lawrence Livermore Last Chance to View Posters and Exhibits! National Laboratory 10:00 AM S54 Next Generation Biomarkers and the 8:30 AM–9:30 AM Texas Ballroom F Exposome Joe Shuga, University of California, Berkeley PLENARY LECTURE 3 Keap1 EYE ON NRF2: TARGETS FOR DISEASE PREVENTION 10:30 AM S55 Phosphorylation of Smc1 Can Be Used to Measure Activation of the DNA Damage Chairperson: Patricia L. Opresko, University of Pittsburgh Response and to Detect Human Exposures to Ionizing Radiation Lecturer: Thomas W. Kensler, University of Pittsburgh Richard G. Ivey, Fred Hutchinson Cancer Research Center 11:00 AM Break 9:45 AM–12:15 PM Texas Ballroom F 11:15 AM S56 Magneto-Nano Chips for Ultrasensitive and SYMPOSIUM 10 Multiplex Detection of Biomarkers of Tumor and Exposure INFLAMMATION: FROM MOLECULES TO HUMAN Shan X. Wang, Stanford University POPULATIONS 11:45 AM S57 TP-53 Mutational Signature of an Chairperson: Leona D. Samson, Massachusetts Institute of Environmental Carcinogen Technology Grollman AP1, Moriya M1, Jelakovic B2, 3 3 4 5 9:45 AM S48 Slade N , Brdar B , Medverec Z , Wu L , Processing and Consequences of Oxidative 6 1 6 DNA Damage Zavadil J , Hatchwell E , Wu X-R , Fernandes A1, Dickman K1, Chen C-H7, Susan S. Wallace, University of Vermont Pu Y-S7. 1Stony Brook University, Stony Brook, 10:10 AM S49 Etiologic Linkage of Mitochondrial Genome NY, United States, 2University of Zagreb, Damage to Inflammation Zagreb, Croatia, 3Rudjer Boskovic Institute, 4 Sankar Mitra, University of Texas, Galveston Zagreb, Croatia, Josip Bencevic General Hospital, Zagreb, Croatia, 5Roche Molecular 10:35 AM S50 Role of DNA Repair in Suppressing Systems, Pleasanton, CA, United States, 6New Inflammation-Induced Disease York University, New York, NY, United States, Leona D. Samson, Massachusetts Institute of 7National Taiwan University, Taiwan, China Technology 11:00 AM Break

28 Fort Worth, Texas, U.S.A. • October 23–27, 2010 Tuesday

12:00 NOON S58 Epigenetic Markers of Hepatotoxicity: 3:35 PM S62 Short Term Changes in Gene Expression A Nevirapine Story Can Lead to Long Term Epigenetic Pereira SA1,2, Tryndyak VP2, Pogribny IP2, Reprogramming Beland FA2. 1Department of Pharmacology and Mitchell S. Turker, Oregon Health and Science CEDOC, Faculty of Medical Sciences, New University University of Lisbon, Campo Mártires da Pátria, Lisbon, Portugal, 2Division of Biochemical 4:00 PM Discussion Toxicology, National Center for Toxicological Research, Jefferson, AR, United States 2:15 PM–4:15 PM Texas Ballroom G PLATFORM SESSION 2 12:15 PM–2:15 PM LUNCH ON YOUR OWN HERITABLE MUTATIONS/CANCER Chairpersons: Jessica L. Lyon, New York University School 12:30 PM–2:00 PM Sundance 2 of Medicine and Antoine M. Snijders, Lawrence Berkeley WEMS LUNCHEON National Laboratories THE LEAKY PIPELINE OF WOMEN IN SCIENCE: PATCHING Organized by the Heritable Mutation and Disease Special THE PIPE OR REBUILDING THE INFRASTRUCTURE? Interest Group Chairpersons: Brinda Mahadevan, Abbott Laboratories and Presenting author is underlined. Marilyn J. Aardema, Marilyn Aardema Consulting, LLC 2:15 PM 7 Mainstream and Sidestream Tobacco Smoke Primary Sponsor: Research Corporation for Science Induce Mutations in Male Germ Cells but Advancement Not Micronuclei in Erythrocytes in the Mouse Marchetti F1, Polyzos A1, William A2, Lecturer: Carrie D. Wolinetz, Association of American Bishop J3, Yauk C2. 1Lawrence Berkeley National Universities Laboratory, Berkeley, CA, United States, 2Health Canada, Ottawa, ON, Canada, 3NIEHS, Research Triangle Park, NC, United States 12:45 PM–2:00 PM Sundance 3 2:30 PM 8 Prenatal and Postnatal Cigarette Smoke HOLLAENDER Committee MEETING Exposures Increase Susceptibility to Adult (Lunch on Your Own) Disease Lyon JL, Gordon T. New York University School of Medicine, Tuxedo, NY, United States 2:15 PM–4:15 PM Texas Ballroom F 2:45 PM 9 Early and Persistent Low Dose Damage SYMPOSIUM 12 Response Pathways in the Mouse Mammary Gland Depends on Genotype, Tissue DNA REPAIR, EPIGENETICS, AND GENOMIC STABILITY Compartment and Exposure Regimen Chairpersons: Bevin P. Engelward, Massachusetts Institute Marchetti F, Snijders AM, Bhatnagar S, Parvin B, Han J, Lenburg M, Wyrobek AJ. Lawrence of Technology and Mitchell S. Turker, Oregon Health and Berkeley National Laboratory, Berkeley, CA, Science University United States Organized by the Epigenetics Special Interest Group 3:00 PM 10 Normal Tissue Injury Responses in Mammary Glands after Low Doses of Supported in part by: Integrated Laboratory Systems Ionizing Radiation 2:15 PM Introduction Snijders AM, Marchetti F, Bhatnagar S, Pendem Bevin P. Engelward, Massachusetts Institute of SV, Bjornstad K, Mao JH, Blakely E, Cooper Technology PK, Wyrobek AJ. Lawrence Berkeley National Laboratory, Berkeley, CA, United States 2:20 PM S59 Epigenetic Changes Promote Mutations 3:15 PM 11 Reduction in Telomerase Activity and Alfonso Bellacosa, Fox Chase Cancer Center Telomere Length: An Early Event in 2:45 PM S60 Histone Methylation: The Link between Carcinogenesis by PCBs? Chromatin Structure and DNA Repair Perumal Kuppusamy S, Jacobus J, Klingelhutz Brendan D. Price, Dana-Farber Cancer AJ, Lehmler HJ, Robertson LW, Ludewig G. The Institute University of Iowa, Iowa City, IA, United States 3:10 PM S61 Exploring the DNA Repair-Chromatin Remodeling Interface Sandeep Burma, UT Southwestern Medical Center, Dallas 29 st Tuesday 41 Annual Meeting of the Environmental Mutagen Society

3:30 PM 12 Role of von-Hippel Lindau Tumor Suppressor 2:45 PM 17 Reticulocyte Ratios Estimated by Manual Gene Mutations in the Modulation of and Flow-Based Methods in the Mammalian Susceptibility to Environmental Carcinogens Micronucleus Test: A Need to Update the DeSimone MC1,2, Rathmell WK1, Threadgill Guideline? DW1,2. 1Curriculum in Toxicology, UNC LeBaron MJ1, Schisler MR1, Torous DK2, Chapel Hill, Chapel Hill, NC, United States, Dertinger SD2, Gollapudi BB1. 1The Dow 2Department of Genetics, NCSU, Raleigh, NC, Chemical Company, Midland, MI, United States, United States 2Litron Laboratories, Rochester, NY, United States 3:45 PM 13 Mechanisms of Chromosomal Instability in Melanoma 3:00 PM 18 Novel Mechanism-Based Reporter Cell Kaufmann W, Carson C, Zhou Y, Simpson D, Systems for Assessment of Genotoxicity and Omolo B, Chu H, Ibrahim J, Shields J, Thomas Oxidative Stress Induction NE. University of North Carolina, Chapel Hill, Hendriks G1, Atallah M1, Morolli B1, NC, United States van de Water B2, Vrieling H1. 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden 4:00 PM 14 Automated Classification of Human University, Leiden, Netherlands Metaphase Chromosomes: Optimization of an Adaptive Computerized Scheme and 3:15 PM 19 Metabolism and Genotoxicity of Food Recognition of the Philadelphia Chromosome Contaminants: Description of a New Mulvihill JJ1, Wang X2, Zheng B2, Li S1, Genotoxic Assay Liu H3. 1Department of Pediatrics, University of Audebert M, Riu A, Jacques C, Hillenweck A, Oklahoma Health Sciences Center, Oklahoma Jamin E, Zalko D, Cravedi JP. INRA UMR1089, City, OK, United States, 2Department of Toulouse, France Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 3Center 3:30 PM 20 Activating Chemical Carcinogens by for Bioengineering, Electrical & Computer Expressing Cytochrome P450 Polymorphisms Engineering Department, University of in Budding Yeast 1,2 1 Oklahoma, Norman, OK, United States Fasullo MT . Ordway Research Institute, Albany, NY, United States, 2State University of New York at Albany, Albany, NY, United States 2:15 PM–4:15 PM Texas Ballroom I 3:45 PM 21 The Genotoxicity of Titanium Dioxide and PLATFORM SESSION 3 Cerium Dioxide Nanoparticles in Human Respiratory Epithelial Cells TOXICOLOGY Prasad RY1, Tennant AH2, Kligerman AD2, 2 2 1 Chairpersons: Matthew J. LeBaron, The Dow Chemical Blackman CF , DeMarini DM . Student Company and Lya G. Hernandez, The National Institute for Contractor, Integrated Systems Toxicology Division, US EPA, Research Triangle Park, NC, Public Health and the Environment (RIVM) United States, 2Integrated Systems Toxicology Organized by the Transgenic and In Vivo Mutagenesis Special Division, US EPA, Research Triangle Park, NC, United States Interest Group and the Risk Assessment Special Interest Group 4:00 PM 22 Particle Size Does Not Impact Genotoxic Properties of Nanomaterials In Vivo in the Presenting author is underlined. Comet or Micronucleus Assays Pfuhler S, Downs T, Jester J, Lynch M, Reeder 2:15 PM 15 Comparison of Carcinogenic Potency R, Sarlo K. Procter & Gamble Co, Cincinnati, Estimates to In Vivo Genotoxic Potencies OH, United States from the Micronucleus, Transgenic Rodent Mutation and Comet Assay Using the Benchmark Dose Approach 4:15 PM–4:30 PM Texas Ballroom Foyer Hernandez LG, Slob W, van Steeg H, van Benthem J. The National Institute for Public BREAK Health and the Environment (RIVM), Bilthoven, Netherlands 2:30 PM 16 Xenoantiandrogens: Risk Factors for Androgen Receptor Mutation in Hypospadias Jyothy A1, Sharma V1, Venkateshwari A1, Munshi A1, Sujatha M1, Singh R2, Thangaraj K2. 1Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad, AP, India, 2Centre for Cellular and Molecular Biology, Hyderabad, AP, India

30 Fort Worth, Texas, U.S.A. • October 23–27, 2010 Tuesday Wednesday

4:30 PM–5:45 PM Texas Ballroom F Wednesday, October 27 SYMPOSIUM 13 CYTOGENETICS AND EMS: THE SHELLY WOLFF LEGACY 7:00 AM–11:30 AM Texas Ballroom Foyer Chairperson: Shelia M. Galloway, Merck Research REGISTRATION Laboratories 4:30 PM Introduction: Sheldon Wolff and His 7:00 AM–8:30 AM breakFAST MEETINGS Continuing Influence on Cytogenetics Environmental Genetic Sundance 3 and Environmental Sciences Toxicology Special Interest Group Shelia M. Galloway, Merck Research Laboratories Leaders: Christopher M. Somers, University of Regina and Carol D. Swartz, Integrated Laboratory Systems, Inc. 4:45 PM S63 Chromosome Structure and Repair: The Early Years Finance Committee Sundance 4 John A. Heddle, York University Molecular Epidemiology Sundance 2 5:05 PM S64 SCE and ABCW: The Language of Special Interest Group Environmental Science Leaders: Radim J. Sram, Institute of Experimental Medicine William F. Morgan, Pacific Northwest National and Miriam C. Poirier, National Cancer Institute, NIH Laboratory 5:25 PM S65 Low Dose Effects: The Final Frontier 8:30 AM–9:30 AM Texas Ballroom F Jeffrey L. Schwartz, University of Washington PLENARY LECTURE 4 WEMS 6:15 PM–7:15 PM Texas Ballroom F INTERDISCIPLINARY COLLABORATIONS: A BIG-PICTURE EMS AWARD LECTURE APPROACH TOWARD UNDERSTANDING THE CAUSES AND BASE EXCISION REPAIR AND ENVIRONMENTAL CONSEQUENCES OF CHILDHOOD CANCER MUTAGENESIS Chairperson: Kristine L. Witt, National Institute of Award Recipient: Samuel H. Wilson, National Institute of Environmental Health Sciences, NIH Environmental Health Sciences Lecturer: Julie A. Ross, University of Minnesota Cancer Center 7:30 PM–11:00 PM Texas Ballroom E EMS BANQUET 9:45 AM–12:15 PM Texas Ballroom G Awards Presentation by Michael J. Plewa SYMPOSIUM 14 Alexander Hollaender Award FRAGILE-X SYNDROME: GENES TO THERAPY EMS Service Award Chairpersons: Suzanne M. Morris, National Center for Student Education Award Toxicological Research, U.S. FDA, Donald R. Mattison, Student and New Investigator Travel Awards Eunice Kennedy Shriver National Institute of Child Health Dancing to the Music of The Genotones and Human Development, NIH, and John J. Mulvihill, University of Oklahoma Health Sciences Center Supported in part by: March of Dimes Birth Defects Foundation 9:45 AM S66 Braking and Breaking: The DNA Damage Response and Fragile-X Syndrome Karen P. Usdin, National Institute of Diabetes, Digestive and Kidney Diseases, NIH 10:10 AM S67 Fragile-X Premutation Associated Disorders: Not One, but Many Stephanie Sherman, Emory University School of Medicine

31 st Wednesday 41 Annual Meeting of the Environmental Mutagen Society

10:35 AM S68 Treatment of Fragile X Syndrome: Moving 11:15 AM S76 DNA Damage in Cattle Near Industrial from Supportive to Targeted Interventions: Pollution Sources Can We “Cure” Intellectual Disability? Wesley T. Bissett, Texas A&M University Elisabeth M. Berry-Kravis, Rush University Medical Center 11:30 AM S77 Biomarkers of Chromosomal Damage and Their Potential Application to the 2010 Gulf 11:00 AM Break of Mexico Oil Spill John W. Bickham, Purdue University 11:15 AM S69 Pre-Clinical Drug Development Studies in Fragile-X: The NIH Perspective 11:45 AM S78 Transmissible Cancer in Wildlife Andrea C. Beckel-Mitchener, National Institute Elizabeth P. Murchison, Wellcome Trust Sanger of Mental Health, NIH Institute 11:40 AM S70 Mouse Models of Fragile-X Syndrome 12:00 NOON S79 Association between DNA Damage and the Demonstrate Acute Requirement for Fmr1 Use of Pesticides in Tomato Crop David L. Nelson, Baylor College of Medicine Narváez DM1, Olaya LF1, Varona M2, Londoño A3, Páez MI4, Castro RA5, Groot H1. 1Universidad de los Andes, Bogotá, Colombia, 9:45 AM–12:15 PM Texas Ballroom F 2Instituto Nacional de Salud, Bogotá, Colombia, 3 SYMPOSIUM 15 Universidad del Quindío, Armenia, Colombia, 4Universidad del Valle, Cali, Colombia, GENETIC TOXICOLOGY OF WILDLIFE AND OTHER 5Instituto Colombiano Agropecuario, Bogotá, INDICATOR SPECIES Colombia Chairpersons: Christopher M. Somers, University of Regina and Carol D. Swartz, Integrated Laboratory Systems, Inc. 12:30 PM–1:45 PM cOMMITTEE MEETINGS Organized by the Environmental Genetic Toxicology Special 2011 Program Committee Sundance 3 Interest Group (Second Meeting) Underlined author indicates presenter. Publication Policy Committee Sundance 4 9:45 AM S71 Origin and Fate of Environmental Mutagens Paul A. White, Health Canada 1:45 PM–3:00 PM Sundance 1 EMS COUNCIL MEETING 10:00 AM S72 Individual and Population Responses to Mutagens John W. Bickham, Purdue University nd 10:15 AM S73 Biomarker Responses in Indicator Species: Tar Creek Superfund Site Karen McBee, Oklahoma State University 10:30 AM S74 Quantifying Mitochondrial and Nuclear DNA Damage in Sentinel Species 42 Joel N. Meyer, Duke University 10:45 AM S75 DNA Damage in Marine Species John Pierce Wise, Sr., University of Southern nnual Maine A 11:00 AM Break

Future Meetings EMS 42 nd Annual Meeting EMS 43 rd Annual Meeting October 15–19, 2011 September 8–12, 2012 Hilton Montréal Bonaventure Hyatt Regency Bellevue (On Seattle’s Eastside) Montréal, Québec, Canada Bellevue, Washington

32 Environmental Impacts on the Genome and Epigenome: Mechanisms and Risks

nd 42< Annual

EMS President: Meeting Jeffrey L. Schwartz Program Chair: Montréal, Québec Catherine B. Klein October 15–19, 2011 | Hilton Montréal Bonaventure Photographs are Photographs courtesy Montréal, are of photographed the by Tourisme Patrick Mainville. See you next year 33 Town Hall Meeting Features

….a new collaborative tool to connect you with your professional world: • Search • Communicate • Collaborate • Connect

EMS Members now have an on-line community of their very own.

EMS Connect…Your Community!

Learn more about it Sunday, October 24 12:45 PM–2:00 PM Texas Ballroom F Discussion led by Ofelia A. Olivero.

34 What is EMS Connect? The Environmental Mutagen Society’s newest member benefit. A secure members-only on-line site for invigorating scientific interaction. Use EMS Connect to:

• Post your photograph, CV, SIG and committee memberships, current Society offices held, research interests and expertise, and your affiliations with other professional societies on the enhanced Membership Directory. • Search the Membership Directory to find potential collaborators, mentors, or colleagues to connect with at different scientific meetings. • Communicate, review, and post documents with fellow SIG and committee members. • Keep updated with Society reports, minutes, and announcements, and provide feedback to leadership. • Learn of current FASEB activities. • Initiate discussion groups and share blogs. • And do so much more. Use your imagination! It is easy to use and access EMS Connect. Just use your EMS member login. It’s where to connect with your colleagues throughout the year!

Log in to EMS Connect Today!

• Access Your Profile and MyPage—as an EMS member you already have a Profile and MyPage established for you to customize.

• Update Your Profile and MyPage with your picture and respond to Your Profile items. These are the first steps in customizing your MyPage.

• Upload your CV—this enhances your colleagues’ knowledge about YOU.

• Search for EMS Members—via the robust enhanced Membership Directory.

• Use your EMS Member login to access EMS Connect and begin customizing your MyPage—it is easy. BE CONNECTED.

35 st Exhibitors Exhibitors • 41 Annual Meeting of the EMS

Exhibits

Exhibits and Posters are located in Texas Ballroom E and will be open the following times:

Sunday, October 24, 2010 4:30 PM–6:30 PM Monday, October 25, 2010 8:30 AM–6:30 PM Tuesday, October 26, 2010 8:30 AM–11:30 AM

BioReliance Corporation Booth 5 Scott Hickman Phone: (800) 756-5658 14920 Broschart Road Fax: (301) 738-2362 Rockville, MD 20850 E-mail: [email protected] United States Web site: www.bioreliance.com BioReliance is a leading provider of outsourcing services for pharmaceutical and biopharmaceutical companies, as well as chemicals, consumer products and medical devices. Specializing in mutagenicity testing, our scientific staff and state-of-the-art facilities provide the most complete and comprehensive toxicology resources available anywhere.

Cytocell Ltd. Booth 2 Peter Mousseau Phone: (860) 298-8382 83 Maple Avenue Fax: (860) 298-8586 Windsor, CT 06095 E-mail: [email protected] United States Web site: www.rainbowscientific.com Cytocell is a leading manufacturer in the supply of DNA Fluorescent In Situ Hybridization (FISH) probes for genetic toxicology studies. Cytocell offers complete ranges of whole chromosomes painting probes, enumeration probes, and single copy probes for the detection of structural chromosomal aberrations and aneuploidy. Cytocell will now manufacture customized FISH probes produced to your specifications.

FASEB Booth 9 Cordelia Adams Phone: (301) 634-7930 9650 Rockville Pike Fax: (301) 634-7253 Bethesda, MD 20814 E-mail: [email protected] United States Web site: www.faseb.org FASEB MARC Program provides a variety of activities to support the training of minority students, postdoctorates, faculty, and scientists in the biomedical and behavioral sciences. We offer travel awards for scientific meetings, research conferences, and student summer research opportunities programs. We also sponsor Career Development Programs including grantsmanship training seminars.

Helix3 Inc. Booth 12 Marie Vasquez Phone: (919) 462-8105 100 Southcenter Court Fax: (919) 462-8106 Suite 900 E-mail: [email protected] Morrisville, NC 27560 Web site: www.helix3inc.com United States Helix3 is a GLP contract research organization specializing in providing in vitro and in vivo comet assay and research studies for regulatory submissions. With over 15 years experience incorporating the comet assay in safety testing programs and risk assessment studies, Helix3 is the leader in providing the most reliable and efficient GLP-complaint comet assay and research services.

36 st Exhibitors • 41 Annual Meeting of the EMS Exhibitors

Leadscope, INC. Booth 7 Heather Landon Phone: (614) 675-3730 1393 Dublin Road Fax: (614) 675-3732 Columbus, OH 43215 E-mail: [email protected] United States Web site: www.leadscope.com Leadscope licenses high quality toxicity databases and QSAR models developed through our CRADA with the U.S. FDA. The databases and models allow scientists to predict the potential toxicity and adverse human clinical effects of pharmaceuticals (including impurities), cosmetics, food products, and chemicals. The Models, built by the FDA, employ closed training sets prepared using both proprietary and non- proprietary data.

Metasystems Booth 8 John Fonte Phone: (617) 924-9950 300 Bear Hill Road Fax: (617) 924-9954 Waltham, MA 02451 E-mail: [email protected] United States Web site: www.metasystems.org Metasystems provides innovative genetic imaging and slide scanning systems for automation in the Life Sciences, MetaCyte for automated FISH and IHC analysis and Spot Counting. RCDetect for rare cell detection, Isis for FISH imaging, with software upgrades including CGH and mFISH analysis and lkaros for automatic karyotyping plus patient database.

Perceptive Instruments LTD. Booth 4 Gary Kyle Phone: +44 1440 730 773 Blois Meadow Business Centre Fax: +44 1440 730 630 Steeple Bumpstead E-mail: [email protected] Haverhill Suffolk Web site: perceptive.co.uk United Kingdom Perceptive Instruments develops and markets products for genetic toxicology assays. These include automatic colony counting systems for Ames and MLA, and image analysis systems for UDS and Comet assays. We also developed the Ames Study Manager; a comprehensive program for conducting and reporting regulatory Ames tests. All our systems are designed for compliance with GLP and 21 CFR part 11.

Trevigen Booth 10 Shamain Dang Phone: (301) 216-2800 8405 Helgerman Court Fax: (301) 560-4973 Gaithersburg, MD 50877 E-mail: [email protected] United States Web site: www.trevigen.com The environmental genome project (EGP) has identified eight categories of environmentally responsive genes (ERG).These categories include cell cycle, DNA repair, cell division, cell signaling, cell structure, gene expression, apoptosis, and metabolism. To study environmental mutagens and DNA repair Trevigen is offering well characterized DNA repair gene knockdown cell lines.

WIL Research Company Booth 1 Mike Schlosser Phone: (847) 972-2500 8025 Lamon Avenue Fax: (847) 972-2506 Skokie, IL 60077 E-mail: [email protected] United States Web site: www.midwestbioresearch.com Partner with a global genetic toxicology leader. With locations in North America (Midwest BioResearch, WIL Research Laboratories) and Europe (NOTOX), we continue to expand our leading genetic toxicology services to the global pharmaceutical, chemical, and agricultural industries. From standard ICH and OECD compliant assays to the most regulatory predictive microscreens on the market, we can help you save time and money. 37 Restaurants Omni Fort Worth Restaurants

Omni Fort Worth Restaurants Bob’s Steak & Chop House Wine Thief Bob’s Steak & Chop House is a nationally renowned steak Relax and unwind in this secluded and inviting wine bar. house specializing in the finest corn-fed, Midwestern prime The ambiance of the décor and comfortable lighting create beef. Their menu formula is simple: incredible meat, gigantic the perfect location for cocktail hour. Enjoy patio seating shrimp, fabulous salads, and decadent desserts. overlooking the Fort Worth Water Gardens. Choose from an array of hand-selected labels with a wide range of Hours of Operation complexity. Wine Thief also serves a tasteful selection of Monday–Thursday 5:00 PM–10:00 PM appetizers and European and regional artisanal cheese. Friday–Saturday 5:00 PM–11:00 PM Sunday Closed Hours of Operation Monday–Saturday 4:00 PM–11:00 PM Cast Iron Restaurant Sunday Closed Serving three meals daily, Cast Iron captures the true flavor of Fort Worth with an emphasis on local ingredients and Whiskey & Rye southern style with a twist on hometown classics. Whether This great neighborhood bar features regional draft beers cozying up to the fireplace or sharing from the family-style from Rahr & Sons Brewery, HD TV’s and live entertainment. menu at the large family tables, the dining experience will be The oversized leather chairs and complimentary pool tables enjoyed by all. will soon have you calling the staff by name. Whiskey & Rye offers a southern twist on basic bar entrees from Grilled Hours of Operation Angus Beef Burgers and Crab Sliders to their signature Fajita Breakfast Buffet/A la Carte Nachos and Rahr’s “Ugly Pug” Baby Back Short Ribs. Monday–Friday 6:00 AM–10:30 AM Saturday 6:00 AM–12:00 NOON Hours of Operation Monday–Thursday 11:30 AM–12:00 MIDNIGHT Brunch Friday–Saturday 11:30 AM–1:00 AM Sunday 11:00 AM–2:00 PM Sunday 11:30 AM–10:00 PM

Lunch Buffet/A la Carte Monday–Friday 11:00 AM–2:00 PM Water Horse Pool Bar Enjoy the comfortable lounge furniture, a full-service bar, Lunch HD TV’s and fabulous food. Located on the rooftop terrace, Saturday 12:00 NOON–2:00 PM Water Horse is a great place to meet to enjoy happy hour specials and their outdoor grill. Dinner Monday–Sunday 5:00 PM–10:00 PM Hours of Operation Sunday–Friday 11:00 AM–10:00 PM Starbucks® Saturday 10:00 AM–10:00 PM A full-service Starbucks located within the hotel.

Hours of Operation Monday–Sunday 6:00 AM–9:00 PM

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Notes

40 Sustaining Members and Institutional Representatives Silver Boehringer Ingelheim Pharmaceuticals, Inc. GlaxoSmithKline Matthew S. Bogdanffy Anthony Mark Lynch Bronze Abbott Laboratories Pfizer Inc. Lori A. Gallenberg Geralyn L. DeVito Bristol-Myers Squibb Co. The Procter & Gamble Company Laura L. Custer Stefan J. Pfuhler EMS 2010 Thank You EMS sincerely appreciates the effort and hard work of the following people who helped make this a successful and worthwhile meeting.

2010 Program Committee Nagu Keshava Kristine L. Witt Igor Kovalchuk Chin-Rang Yang Workshop, Symposium, Matthew J. LeBaron Carole L. Yauk Mats Ljungman Platform Chairpersons Abstract Reviewers: and Organizers: Jessica L. Lyon Brinda Mahadevan Marilyn J. Aardema Marilyn J. Aardema Francesco Marchetti Janet E. Baulch Janet E. Baulch Donald R. Mattison Jason H. Bielas Jason H. Bielas Paul S. Miller Stephen D. Dertinger P.J. Brooks William F. Morgan Sheila M. Galloway Andrew B. Buermeyer Suzanne M. Morris Nina T. Holland Christine E. Canman John J. Mulvihill William K. Kaufmann Matthew A. Coleman John P. Murnane Nagu Keshava Meredith E. Crosby Patricia L. Opresko Andrew D. Kligerman Krista L. Dobo Stefan J. Pfuhler Brinda Mahadevan Rosalie K. Elespuru Igor P. Pogribny Larry H. Thompson Bevin P. Engelward Miriam C. Poirier Thomas E. Wilson Patricia A. Escobar Leona D. Samson James C. Fuscoe Photographer: Antoine M. Snijders Sheila M. Galloway Sandy K. Weiner Christopher M. Somers Philip C. Hanawalt Radim J. Sram Other Key Individuals: Paul T. Henderson Carol D. Swartz Tonia M. Masson Lya G. Hernandez Mitchell S. Turker Becca Isakower Jennifer A. Hobin Karen M. Vasquez Maureen Kettering William K. Kaufmann Michael D. Waters Christy Ours On se rev S oit l’an ee yo prochain! u next year

Environmental Mutagen Society 1821 Michael Faraday Drive Suite 300 Reston, VA 20190-5348 E-mail: [email protected] EMS Web site: www.ems-us.org Cert no. XXX-XXX-XXXX