Ultrasound localization microscopy (ULM) June 04, Fast super-resolution ultrasound microvessel imaging using has been proposed to image 2021 spatiotemporal data with deep fully convolutional neural network microvasculature beyond the ultrasound diffraction limit. Pregnancy is a unique physiological state January A Protocol for Evaluating Vital Signs and Maternal-Fetal in which two individuals coexist: the 04, 2021 Parameters Using High-Resolution Ultrasound in Pregnant Mice mother and the fetus. Abdominal aortic aneurysm (AAA) is January Pharmacological inhibition of Notch signaling regresses pre- characterized by transmural infiltration of 01, 2019 established abdominal aortic aneurysm myeloid cells at the vascular injury site. A decline in capillary density and blood January Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a flow with age is a major cause of mortality 01, 2018 Reversible Cause of Vascular Aging and morbidity. Abdominal aortic aneurysms are January Development and growth trends in angiotensin II-induced murine pathological dilations that can suddenly 01, 2018 dissecting abdominal aortic aneurysms rupture, causing more than 15,000 deaths in the U.S. annually. Disruption of vulnerable atherosclerotic August 24, Ultraselective Carbon Nanotubes for Photoacoustic Imaging of plaques often leads to myocardial 2021 Inflamed Atherosclerotic Plaques infarction and stroke, the leading causes of morbidity and mortality in the We presently show that sEH knockout repressed nicotine-induced arterial August 24, Soluble epoxide hydrolase deletion attenuated nicotine-induced stiffness and extracellular matrix 2021 arterial stiffness via limiting the loss of SIRT1 remodeling via SIRT1-induced YAP deacetylat Fish protein consumption exerts Anti-atherogenic effect of 10% supplementation of anchovy August 24, beneficial metabolic effects on human (Engraulis encrasicolus) waste protein hydrolysates in apoe- 2021 health, also correlat-ing with a decreased deficient mice risk for cardiovascular disease. A Thrombin-Responsive Nanoprobe for in Vivo Visualization of Early spontaneous detection of thrombin August 09, Thrombus Formation through Three-Dimensional activation benefits precise theranostics 2021 Optical/Computed Tomography Hybrid Imaging for thrombotic vascular disease. Arterial stiffness due to the vessel August 09, Bioinspired therapeutic platform based on extracellular vesicles remodeling is closely linked to raised 2021 for prevention of arterial wall remodeling in hypertension blood pressure, and its physiopathologic mechanism is still not fully unde

Corneal neovascularization (CNV) July 07, In vivo photoacoustic imaging for monitoring treatment outcome of compromises corneal avascularity and 2021 corneal neovascularization with metformin eye drops visual acuity. Age is a major risk factor for abdominal July 07, Senolytic agents lessen the severity of abdominal aortic aortic aneurysm (AAA), for which 2021 aneurysm in aged mice treatment options are limited to surgical intervention for large AAA and wat Baroreflex dysfunction is partly implicated Chronic stimulation of group II metabotropic glutamate receptors June 28, in hypertension and one responsible in the medulla oblongata attenuates hypertension development in 2021 region is the dorsal medulla oblongata spontaneously hypertensive rats including the nucleus tractus s Thoracic aortic aneurysm, as occurs in June 25, Aortic disease in Marfan syndrome is caused by overactivation of Marfan syndrome, is generally 2021 sGC-PRKG signaling by NO asymptomatic until dissection or rupture, requiring surgical intervention as the Plateletendothelial interactions have Contrastenhanced ultrasound molecular imaging of activated June 25, been linked to increased inflammatory platelets in the progression of atherosclerosis using microbubbles 2021 activation and a prothrombotic state in bearing the von Willebrand factor A1 domain atherosclerosis. June 10, Doxorubicin induces arterial stiffness: A comprehensive in vivo Arterial stiffness is an important predictor 2021 and ex vivo evaluation of vascular toxicity in mice of cardiovascular risk. Background: Ascending and abdominal Mst1/2 Kinases Inhibitor, XMU-MP-1, Attenuates Angiotensin II- aortic aneurysms (AAs) are June 10, Induced Ascending Aortic Expansion in Hypercholesterolemic asymptomatic, permanent dilations of the 2021 Mice aorta with surgical intervention as the curren Abdominal aortic aneurysm (AAA) June 10, Systemic delivery of targeted nanotherapeutic reverses disease causes dilation of the aorta, 2021 angiotensin II-induced abdominal aortic aneurysms in mice leading to aortic rupture and death if not treated early. Chronic inflammation plays an essential June 09, Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm role in the pathogenesis of abdominal 2021 Formation in ApoE−/− Mice aortic aneurysm (AAA), a progressive segmental abdominal aortic dilation Rapid endothelialization is crucial for in Gelatin coating promotes in situ endothelialization of electrospun June 09, situ tissue engineering vascular grafts to polycaprolactone vascular grafts 2021 prevent graft failure in the long-term.

June 09, Stiffness of aortic arch and carotid arteries increases in ApoE- Arterial stiffness is an effective predictor 2021 knockout mice with high-fat diet: Evidence from echocardiography of atherosclerosis. Three-dimensional visualization and improved quantification with The purpose of this study was to improve June 07, super-resolution ultrasound imaging - Validation framework for the morphological analysis of 2021 analysis of microvascular morphology using a chicken embryo microvascular networks depicted in three- model dimensional (3D) super-resolution ultr June 07, SNF5 promotes IL-1β expression via H3K4me1 in atherosclerosis Homocysteine (Hcy) is a strong and 2021 induced by homocysteine independent risk factor of atherosclerosis. It has been shown that thoracic aortic June 07, Loxl4 abrogation does not exaggerate angiotensin ii-induced aneurysm and dissection (TAAD) could 2021 thoracic or abdominal aortic aneurysm in mice be a Mendelian trait caused by a single gene mutation. Abdominal aortic aneurysm (AAA) is a common life-threatening condition June 04, Rolipram prevents the formation of abdominal aortic aneurysm characterized by exacerbated 2021 (Aaa) in mice: pde4b as a target in AAA inflammation and the generation of reactive oxygen Activation of angiotensin type 2 receptor attenuates testosterone- Preeclampsia is a pregnancy-related June 04, induced hypertension and uterine vascular resistance in pregnant hypertensive disorder with unclear 2021 rats† mechanisms. Elastin (ELN) insufficiency leads to the cardiovascular hallmarks of the June 04, Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin contiguous gene deletion disorder, 2021 Insufficiency Williams–Beuren syndrome, including hypert This short report describes the June 04, Measurement of total liver blood flow in intact anesthetized rats measurement of total liver blood flow in 2021 using ultrasound imaging commonly used laboratory rats using the relatively non-invasive approach of u Cellular transition to hypoxia following June 04, The effect of hypoxia-mimicking responses on improving the tissue injury, has been shown to improve 2021 regeneration of artificial vascular grafts angiogenesis and regeneration in multiple tissues. Airway exposure to eg particulate matter May 28, Accelerated atherosclerosis caused by serum amyloid A response is associated with cardiovascular disease 2021 in lungs of ApoE−/− mice including atherosclerosis. Chemotherapy-induced acute vascular injury involves intracellular Several categories of chemotherapy May 28, generation of ROS via activation of the acid sphingomyelinase confer substantial risk for late-term 2021 pathway vascular morbidity and mortality. It is well-established that long-term Acute glucose influx-induced mitochondrial hyperpolarization March 25, exposure of the vasculature to metabolic inactivates myosin phosphatase as a novel mechanism of 2021 disturbances leads to abnormal vascular vascular smooth muscle contraction tone, while the physiological r Neutrophil extracellular traps (NETs) March 12, Histone citrullination as a novel biomarker and target to inhibit have been implicated in the pathogenesis 2021 progression of abdominal aortic aneurysms of abdominal aortic aneurysms (AAAs). Delivery of drugs and nanomedicines to March 08, Sonopermeation Enhances Uptake and Therapeutic Effect of Free tumors is often heterogeneous and 2021 and Encapsulated Cabazitaxel insufficient and, thus, of limited efficacy. Abdominal aortic aneurysms (AAAs) are March 01, Animal Model Dependent Response to Pentagalloyl Glucose in a local dilation of the aorta and are 2021 Murine Abdominal Aortic Injury associated with significant mortality due to rupture and treatment complic Purpose: P-selectin glycoprotein ligand-1 March 01, P-Selectin Glycoprotein Ligand-1 Deficiency Protects Against (PSGL-1) acts as a crucial regulator for 2021 Aortic Aneurysm Formation Induced by DOCA Plus Salt the inflammatory cells infiltration by mediating the adhesion of le Scope: A main risk factor of Digestive n-6 Lipid Oxidation, a Key Trigger of Vascular March 01, atherosclerosis is a Western diet (WD) Dysfunction and Atherosclerosis in the Western Diet: Protective 2021 rich in n-6 polyunsaturated fatty acids Effects of Apple Polyphenols (PUFAs) sensitive to oxidation. Abdominal aortic aneurysm (AAA) bears March 01, A Dual Role of Heme Oxygenase-1 in Angiotensin II-Induced a high risk of rupture and sudden death of 2021 Abdominal Aortic Aneurysm in the Normolipidemic Mice the patient. Background and Objective: Low shear March 01, Analysis of Syk/PECAM-1 signaling pathway in low shear stress stress (LSS) has been demonstrated to 2021 induced atherosclerosis based on ultrasound imaging be involved in function of vascular endothelial cells. Background: Mechanical homeostasis February Developmental origins of mechanical homeostasis in the aorta promotes proper aortic structure and 23, 2021 function. Background: Diagnosis requires that February Aortic Strain Correlates With Elastin Fragmentation in Fibrillin-1 clinicians communicate and share patient 22, 2021 Hypomorphic Mice information in an efficient manner. Ultrasound molecular imaging of atherosclerosis for early Cardiovascular diseases resulting from February diagnosis and therapeutic evaluation through leucocyte-like atherosclerosis have become a serious 19, 2021 multiple targeted microbubbles threat to human health. Abdominal aortic aneurysm (AAA) is a TRPV5 attenuates abdominal aortic aneurysm in mice by January fatal vascular disease with insidious regulating KLF4-dependent phenotype switch of aortic vascular 18, 2021 symptoms. However, the mechanism smooth muscle cells behind its development remains unclear. Bone marrow-derived mesenchymal stem cells microvesicles Rupture of atherosclerotic plaques January stabilize atherosclerotic plaques by inhibiting NLRP3-mediated constitutes the major cause of thrombosis 18, 2021 macrophage pyroptosis and acute ischemic coronary syndrome. This study uses Bayesian inference to Assessing model mismatch and model selection in a Bayesian quantify the uncertainty of model January uncertainty quantification analysis of a fluid-dynamics model of parameters and haemodynamic 14, 2021 pulmonary blood circulation predictions in a one-dimensional pulmonary circula Background: The pathophysiological roles CFTR plays an important role in the regulation of vascular of cystic fibrosis transmembrane- January resistance and high-fructose/salt-diet induced hypertension in conductance regulator (CFTR) Cl− 14, 2021 mice channels in the regulation of blood pressur Fewer females develop AADs (ascending A validated mouse model capable of recapitulating the protective January aortic aneurysms and dissections) and effects of female sex hormones on ascending aortic aneurysms 14, 2021 the reasons for this protection remain and dissections (AADs) poorly understood. Vasculopathy and the consequential January Thick PCL Fibers Improving Host Remodeling of PGS-PCL ischemia are major medical challenges. 14, 2021 Composite Grafts Implanted in Rat Common Carotid Arteries Grafting is an effective treatment to vascular occlusion. Rupture of abdominal aortic aneurysm January Daphnetin suppresses experimental abdominal aortic aneurysms (AAA) is a devastating event that can be 04, 2021 in mice via inhibition of aortic mural inflammation prevented by inhibiting the growth of small aneurysms. Exposure to air pollutants such as ozone January Early Gestational Exposure to Inhaled Ozone Impairs Maternal (O3) is associated with adverse 04, 2021 Uterine Artery and Cardiac Function pregnancy outcomes, including higher incidence of gestational hypertension, p

Tissue engineered vascular grafts January Effects of Braiding Parameters on Tissue Engineered Vascular (TEVGs) using scaffolds fabricated from 04, 2021 Graft Development braided poly(glycolic acid) (PGA) fibers coated with poly(glycerol sebacate) Sex differences in the time course and mechanisms of vascular Aging is associated with heart and January and cardiac aging in mice: role of the smooth muscle cell vascular dysfunction that contributes to 04, 2021 mineralocorticoid receptor cardiovascular disease (CVD) risk. Factor Xa inhibitor rivaroxaban suppresses experimental Objective: Rivaroxaban is a specific factor January abdominal aortic aneurysm progression via attenuating aortic Xa (FXa) inhibitor for venous 04, 2021 inflammation thromboembolism treatment. A major challenge to treat vascular Bimodal Imaging-Visible Nanomedicine Integrating CXCR4 and January endothelial injury is the restoration of VEGFa Genes Directs Synergistic Reendothelialization of 04, 2021 endothelium integrity in which endothelial Endothelial Progenitor Cells progenitor cells (EPCs) plays Aims: To address the roles of SHP2 in Specific inhibition of SHP2 suppressed abdominal aortic January regulating angiotensin II (Ang II) induced aneurysm formation in mice by augmenting the 04, 2021 abdominal aortic aneurysm (AAA) and immunosuppressive function of MDSCs the potential molecular mechanism While in recent trials the dual pathway January Vascular protective effect of aspirin and rivaroxaban upon inhibition with aspirin plus rivaroxaban 04, 2021 endothelial denudation of the mouse carotid artery has shown to be efficacious in patients with atherosclerotic cardiova Increased transforming growth factor-β January Inhibition of transforming growth factor-β signaling in myeloid cells (TGF-β) signaling contributes to the 04, 2021 ameliorates aortic aneurysmal formation in Marfan syndrome pathophysiology of aortic aneurysm in Marfan syndrome (MFS). Percutaneous coronary intervention (PCI) Effects of different positions of intravascular stent implantation in January has been widely used in the treatment of stenosed vessels on in-stent restenosis: An experimental and 04, 2021 atherosclerosis, while in-stent restenosis numerical simulation study (ISR) has not been comple The spontaneously hypertensive rat November Potential role of intermittent functioning of baroreflexes in the (SHR) is a genetic model of primary 03, 2020 etiology of hypertension in spontaneously hypertensive rats hypertension with an etiology that includes sympathetic overdrive.

Macrophages contribute to abdominal November Macrophage pyroptosis is mediated by immunoproteasome aortic aneurysm (AAA), but the effect of 03, 2020 subunit β5i (LMP7) in abdominal aortic aneurysm macrophage on AAA formation is not totally understood. Introduction: High fructose and salt November Aortic Stiffness and Diastolic Dysfunction in Sprague Dawley Rats consumption continues to be prevalent in 03, 2020 Consuming Short-Term Fructose Plus High Salt Diet western society. In humans, endothelial vasodilator November In vivo measurement of flow-mediated vasodilation in living rats function serves as a surrogate marker for 03, 2020 using high-resolution ultrasound cardiovascular health and is measured as changes in conduit artery diamet Objective: Previous studies have shown A single exposure to eucalyptus smoke sensitizes rats to the October that air pollution exposure primes the postprandial cardiovascular effects of a high carbohydrate oral 16, 2020 body to heightened responses to load everyday stressors of the cardiovascular Changes in soil physical properties due to October Functional Role of Second Heart Field-derived Smooth Muscle traditional methods of puddling for 16, 2020 Cells in Thoracic Aortopathies in Mice lowland rice (Oryza sativa L.) production and post-rice legumes was inv Arteriovenous fistulae (AVF) are the October Artery to vein configuration of arteriovenous fistula improves preferred mode of hemodialysis access, 16, 2020 hemodynamics to increase maturation and patency but 60% of conventional [vein-to-artery (V-A)] AVF fail to mature, and onl Platelet membrane-functionalized nanoparticles with improved Intravenous injection of thrombolytic October targeting ability and lower hemorrhagic risk for thrombolysis drugs is the most effective strategy for the 16, 2020 therapy treatment of thrombotic diseases. To define morphological changes in Age-dependent characterization of carotid and cerebral artery October carotid and cerebral arteries in sickle cell geometries in a transgenic mouse model of sickle cell anemia 16, 2020 transgenic mice (SS) as they age, a using ultrasound and microcomputed tomography combination of ultrasound and micr Mechanical factors, especially wall shear October Ultrasound Assessment of the Relation between Local stress (WSS) and circumferential strain 16, 2020 Hemodynamic Parameters and Plaque Morphology (CS), play an important role in the progression and rupture of ather Coronary artery bypass graft (CABG) has October A novel biodegradable external stent regulates vein graft been confirmed to effectively improve the 16, 2020 remodeling via the Hippo-YAP and mTOR signaling pathways prognosis of coronary artery disease, which is a major public health Mechanosensitive genes regulate multiple cardiovascular October Fluid shear stress modulates endothelial inflammation by targeting pathophysiological processes and 16, 2020 LIMS2 disorders; however, the role of flow- sensitive genes in ather Acute coagulation is one of the vexed September A bi-layered tubular scaffold for effective anti-coagulant in problems in transplantation of small- 09, 2020 vascular tissue engineering diameter artificial blood vessel. Hyaluronan promotes the regeneration of vascular smooth muscle The regeneration of smooth muscle with September with potent contractile function in rapidly biodegradable vascular physiological functions has been a key 09, 2020 grafts challenge in vascular tissue engineering. Porous synthetic grafts made of poly September Slow degrading poly(glycerol sebacate) derivatives improve (glycerol sebacate) (PGS) can transform 09, 2020 vascular graft remodeling in a rat carotid artery interposition model into autologous vascular conduits in vivo upon degradation of PGS. Objective: Central venous stenosis (CVS) September A mouse model of stenosis distal to an arteriovenous fistula is a major cause of arteriovenous fistula 09, 2020 recapitulates human central venous stenosis (AVF) failure. Objective: Receptor interacting proteins September GSK2593074A blocks progression of existing abdominal aortic kinase 1 and 3 (RIPK1 and RIPK3) have 09, 2020 dilation been shown to play essential roles in the pathogenesis of abdominal aor To explore the potential role of Lin28a in Lin28a up-regulation is associated with the formation of restenosis September the development of restenosis after via promoting proliferation and migration of vascular smooth 09, 2020 percutaneous transluminal angioplasty, muscle cells double-balloon injury surgery an Background: The autologous vein Photochemical Tissue Passivation of Arteriovenous Grafts September remains the standard conduit for lower Prevents Long-term Development of Intimal Hyperplasia in a 01, 2020 extremity and coronary artery bypass Swine Model grafting despite a 30%-50% 5-y failure rat Background: Deep venous thrombosis July 01, miR-374b-5p is increased in deep vein thrombosis and negatively (DVT) is one of the most common venous 2020 targets IL-10 thromboembolic (VTE) disorders and the third leading cardiovascular complica Design and fabrication of scaffolds with June 01, Construction of vascular graft with circumferentially oriented three-dimensional (3D) topological cues 2020 microchannels for improving artery regeneration inducing regeneration of the neo-tissue comparable to native one rema Background: Mouse models of mild spinal May 01, Motor transmission defects with sex differences in a new mouse muscular atrophy (SMA) have been 2020 model of mild spinal muscular atrophy extremely challenging to generate. Rheumatoid arthritis (RA) is one of the April 01, TRAIL-expressing cell membrane nanovesicles as an anti- most common chronic autoimmune 2020 inflammatory platform for rheumatoid arthritis therapy diseases. Epidemiological studies have confirmed PM2.5-induced inflammation and lipidome alteration associated March 01, that PM2.5 could contribute to the with the development of atherosclerosis based on a targeted 2020 development of atherosclerosis lipidomic analysis accompanied with lipids dysregulation. This study showed that treatment with a Therapeutic Antibody Against Phosphorylcholine Preserves March 01, therapeutic monoclonal immunoglobulin- Coronary Function and Attenuates Vascular 18F-FDG Uptake in 2020 G1 antibody against phosphorylcholine on Atherosclerotic Mice oxidized phospholipids preserve A cardiovascular stent is a small mesh February Evolution of metallic cardiovascular stent materials: A tube that expands a narrowed or blocked 01, 2020 comparative study among stainless steel, magnesium and zinc coronary artery. Vascular smooth muscle cells (VSMCs) February Tissue-Engineered Vascular Grafts with Advanced Mechanical can be derived in large numbers from 01, 2020 Strength from Human iPSCs human induced pluripotent stem cells (hiPSCs) for producing tissue-engineere Background: The poor long-term patency February Effects of the different-sized external stents on vein graft intimal ratio of vein grafts prevents patients from 01, 2020 hyperplasia and inflammation benefiting from coronary artery bypass graft (CABG). Metabolic syndrome is defined by February Management of metabolic syndrome and reduction in body weight hyperlipidemia and cardiovascular 01, 2020 in type II diabetic mice by inhibiting glycosphingolipid synthesis complications. Vein grafts for coronary artery bypass are February Design and characterization of a porous pouch to prevent not available in more than 30% of 01, 2020 peritoneal adhesions during in vivo vascular graft maturation patients due to prior use or systemic vascular diseases. In liver cirrhosis, oxidative stress plays a January Mitochondria-targeted antioxidant mitoquinone attenuates liver major role in promoting liver inflammation 01, 2020 inflammation and fibrosis in cirrhotic rats and fibrosis. BACKGROUND: Carotid artery January Natriuretic Peptide Receptor 2 Locus Contributes to Carotid intima/media thickness (IMT) is a 01, 2020 Remodeling hallmark trait associated with future cardiovascular events. Introduction: Although thioredoxin- Targeting endothelial thioredoxin-interacting protein (TXNIP) January interacting protein (TXNIP) is involved in protects from metabolic disorder-related impairment of vascular 01, 2020 a variety of biological functions, the function and post-ischemic revascularisation contribution of endothelial TXNIP Exercise preconditioning may protect Exercise preconditioning protects against acute cardiac injury January against cardiac injury induced by induced by lipopolysaccharide through general control 01, 2020 lipopolysaccharide (LPS), but the nonderepressible 2 kinase mechanism is unresolved. An abdominal aortic aneurysm (AAA) is January Measurement of Pulse Propagation Velocity, Distensibility and defined as a localized dilation of the 01, 2020 Strain in an Abdominal Aortic Aneurysm Mouse Model abdominal aorta that exceeds the maximal intraluminal diameter (MILD) by Nanofiber vascular grafts have been January Different degradation rates of nanofiber vascular grafts in small shown to create neovessels made of 01, 2020 and large animal models autologous tissue, by in vivo scaffold biodegradation over time. January Cancer During Pregnancy: The Role of Vascular Toxicity in Breast cancer is diagnosed in ~0.3% of 01, 2020 Chemotherapy-Induced Placental Toxicity pregnant women. Melatonin functions as an endogenous Melatonin protects against thoracic aortic aneurysm and January protective molecule in multiple vascular dissection through SIRT1dependent regulation of oxidative stress 01, 2020 diseases, whereas its effects on thoracic and vascular smooth muscle cell loss aortic aneurysm and dissection Clinical and experimental studies show January AT2R agonist NP6A4 mitigates aortic stiffness and proteolytic that angiotensin II (AngII) promotes 01, 2020 activity in mouse model of aneurysm vascular pathology via activation of AngII type 1 receptors (AT1Rs). January Non-invasive ultrasound detection of cerebrovascular changes in carotid arteries of mice exposed to a 01, 2020 a mouse model of TBI controlled cortical impact. RATIONALE: Chronic thromboembolic pulmonary hypertension (CTEPH) is January Activated Endothelial TGFβ1 Signaling Promotes Venous characterized by defective thrombus 01, 2020 Thrombus Nonresolution in Mice Via Endothelin-1 resolution, pulmonary artery obstruction, and Recent studies have shown that arterial Abnormal Lysosomal Positioning and Small Extracellular Vesicle January medial calcification is mediated by Secretion in Arterial Stiffening and Calcification of Mice Lacking 01, 2020 abnormal release of exosomes/small Mucolipin 1 Gene extracellular vesicles from vascular sm Background: The development of thoracic PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm January aortic aneurysm and dissection (TAAD) is and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL- 01, 2020 mediated by inflammasome activation, 1β Secretion which exacerbates the secretion Preeclampsia (PE) is new onset 17-Hydroxyprogesterone caproate improves T cells and NK cells hypertension during pregnancy January in response to placental ischemia; new mechanisms of action for associated with increased uterine artery 01, 2020 an old drug resistance (UARI) and an imbalance among CD4 + T The aim of this study was to analyze Dermal exposure to the UV filter benzophenone-3 during early whether dermal exposure to January pregnancy affects fetal growth and sex ratio of the progeny in benzophenone 3 (BP-3) during pregnancy 01, 2020 mice affects critical parameters of pregnancy, and w Globally growing problems related to January Local Delivery of Dual MicroRNAs in Trilayered Electrospun Grafts cardiovascular diseases lead to a 01, 2020 for Vascular Regeneration considerable need for synthetic vascular grafts. The spleen is a large lymphoid organ January A durable murine model of spleen transplantation with arterial and located in the abdomen that filters blood 01, 2020 venous anastomoses and regulates the immune system. Percutaneous coronary intervention for January Targeted Repair of Vascular Injury by AdiposeDerived Stem coronary artery disease treatment often 01, 2020 Cells Modified with PSelectin Binding Peptide results in pathological vascular injury, characterized by P-selectin ov Introduction: The aim of the present study Trophoblast-induced spiral artery remodelling and uteroplacental January was to determine the contribution of the haemodynamics in pregnant rats with increased blood pressure 01, 2020 heme oxygenase (HO) system to the induced by heme oxygenase inhibition adaptation of the uteroplacental Atherosclerosis is a multifactorial vascular Improvement of Endothelial Dysfunction of Berberine in January disease triggered by disordered lipid Atherosclerotic Mice and Mechanism Exploring through TMT- 01, 2020 metabolism, characterized by chronic Based Proteomics inflammatory injury, and initi Aim: We sought to explore whether fetal Intrauterine exposure to chronic hypoxia in the rat leads to January hypoxia exposure, an insult of placental progressive diastolic function and increased aortic stiffness from 01, 2020 insufficiency, is associated with left early postnatal developmental stages ventricular dysfunction and in Mechanistic target of rapamycin (mTOR) January mTORC1 Deficiency Modifies Volume Homeostatic Responses to pathway plays a role in features common 01, 2020 Dietary Sodium in a Sex-Specific Manner to both excess salt/aldosterone and cardiovascular/renal diseases. Intermedin 1-53 Ameliorates Homocysteine-Promoted Aim: Vascular calcification (VC) is thought January Atherosclerotic Calcification by Inhibiting Endoplasmic Reticulum to be an independent predictor of 01, 2020 Stress cardiovascular morbidity and mortality. Introduction: We previously reported BOLD-MRI demonstrates acute placental and fetal organ blood oxygen level dependent MRI January hypoperfusion with fetal brain sparing in response to (BOLD-MRI) for monitoring placental and 01, 2020 phenylephrine but not ephedrine fetal hemodynamic changes in mice follow BACKGROUND: Alteration in hemodynamic shear stress at January Nck1, But Not Nck2, Mediates Disturbed FlowInduced p21 atheroprone sites promotes endothelial 01, 2020 Activated Kinase Activation and Endothelial Permeability paracellular pore formation and permeability. IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal aortic aneurysm (AAA) is a January Abdominal Aortic Aneurysm Formation in Mice by Inhibiting vascular disorder that is considered a 01, 2020 Inflammation, Oxidative Stress, and Apoptosis chronic inflammatory disease. Human Umbilical Cord Mesenchymal Stem Cells Attenuate Abdominal aortic aneurysm (AAA) is life- January Abdominal Aortic Aneurysm Progression in Sprague Dawley Rats: threatening for which efficient non- 01, 2020 Implication of Vascular Smooth Muscle Cell Phenotypic surgical treatment strategy has not been Modulation available so far. Background: Hyperoxia (HO) causes January Effects of Klotho supplementation on hyperoxia-induced renal kidney injury in preterm infants; however, 01, 2020 injury in a rodent model of postnatal nephrogenesis whether these effects are modifiable is unknown. Incomplete maternal vascular responses January Increased uterine artery blood flow in hypoxic murine pregnancy is to pregnancy contribute to pregnancy 01, 2020 not sufficient to prevent fetal growth restriction† complications including intrauterine growth restriction (IUGR) and preecla

Chronic infusion of angiotensin-II in January Multimodality Imaging-Based Characterization of Regional atheroprone (ApoE−/−) mice provides a 01, 2020 Material Properties in a Murine Model of Aortic Dissection reproducible model of dissection in the suprarenal abdominal aorta, often Cardiovascular disease is the leading January Hydrogen sulfide stimulates xanthine oxidoreductase conversion cause of death and disability worldwide 01, 2020 to nitrite reductase and formation of NO with increased oxidative stress and reduced NO bioavailability serving a Intravenous Administration of Allogenic Cell-Derived Microvesicles Atherosclerosis and cardiovascular January of Healthy Origins Defends Against Atherosclerotic disease development is the outcome of 01, 2020 Cardiovascular Disease Development by a Direct Action on intermediate processes where endothelial Endothelial Progenitor Cells dysfunction and vascular inflammatio Arterial medial calcification (AMC) is Medial calcification in the arterial wall of smooth muscle cell January associated with crystallization of specific Smpd1 transgenic mice: A ceramidemediated 01, 2020 hydroxyapatite in the extracellular matrix vasculopathy and arterial smooth muscle cells Vascular remodeling can be caused by Increased AT2R expression is induced by AT1R autoantibody via January angiotensin II type 1 receptor (AT1R) two axes, Klf-5/IRF-1 and circErbB4/miR-29a-5p, to promote 01, 2020 autoantibody (AT1-AA), although the VSMC migration related mechanism remains unknown. A 6-month systems toxicology inhalation study in ApoE −/− mice January Smoking cigarettes is harmful to the demonstrates reduced cardiovascular effects of E-vapor aerosols 01, 2020 cardiovascular system. compared with cigarette smoke Although crotonaldehyde (CR) is an January Acute and chronic vascular effects of inhaled crotonaldehyde in abundant α,β-unsaturated aldehyde in 01, 2020 mice: Role of TRPA1 mainstream cigarette smoke (MCS), the cardiovascular toxicity of inhaled CR is In humans, carotid stenosis of 70% and January Mild carotid stenosis creates gradual, progressive, lifelong brain, above might be the cause of clinical 01, 2020 and eye damage: An experimental laboratory rat model symptoms such as transient ischemic attack and stroke. Dual-modality photoacoustic tomography January Label-free photoacoustic and ultrasound imaging for murine (PAT) and 4D ultrasound (4DUS) imaging 01, 2020 atherosclerosis characterization have shown promise for cardiovascular applications, but their use in mur Background and aims: “Shexiang Baoxin Mechanism of angiogenesis promotion with Shexiang Baoxin Pills January Pill” (SBP), a commonly used traditional by regulating function and signaling pathway of endothelial cells 01, 2020 Chinese medicine, has been used to treat through macrophages angina, myocardial infarction Mesenchymal stem cells labeled with Ultrasound monitoring of magnet-guided delivery of mesenchymal January positively charged magnetic lipid–polymer stem cells labeled with magnetic lipid–polymer hybrid 01, 2020 hybrid nanobubbles could be tracked for nanobubbles magnet-guided delivery onto the Because of the high mortality of coronary Ultrasound/Optical DualModality Imaging for Evaluation of January atherosclerotic heart diseases, it is Vulnerable Atherosclerotic Plaques with Osteopontin Targeted 01, 2020 necessary to develop novel early Nanoparticles detection methods for vulnerable athe Endothelial dysfunction is a critical event January Assessment of ICAM-1 N-glycoforms in mouse and human in vascular inflammation characterized, in 01, 2020 models of endothelial dysfunction part, by elevated surface expression of adhesion molecules such Supplemental oxygen (O2) therapy in preterm infants impairs lung January Neonatal hyperoxia exposure induces aortic biomechanical development, but the impact of O2 on 01, 2020 alterations and cardiac dysfunction in juvenile rats long-term systemic vascular structure and functi OBJECTIVE: Abdominal aortic Runx2 (Runt-Related Transcription Factor 2)-Mediated January aneurysms (AAAs) are highly lethal Microcalcification Is a Novel Pathological Characteristic and 01, 2020 diseases without effective clinical Potential Mediator of Abdominal Aortic Aneurysm predictors and therapeutic targets. Valvular heart disease is observed in January Loss of ADAMTS19 causes progressive non-syndromic heart approximately 2% of the general 01, 2020 valve disease population1. Unless there is a genetic January defect/mutation/deletion in a gene, the Dysbiotic 1carbon metabolism in cardiac muscle remodeling 01, 2020 causation of a given disease is chronic dysregulation of gut metabolism. Introduction and objectives: SerpinB3 is a January Hyperdynamic circulatory syndrome in a mouse model transgenic cysteine protease inhibitor involved in 01, 2020 for SerpinB3 several biological activities. Accelerated atherosclerotic calcification is January Loss of PARP-1 attenuates diabetic arteriosclerotic calcification responsible for plaque burden, especially 01, 2020 via Stat1/Runx2 axis in diabetes. Introduction: Saccular aneurysms are Persistence of Intraluminal Thrombus Makes Saccular Aneurysm January thought to have a worse prognosis than More Biologically Active than Fusiform in an Experimental Rat 01, 2020 fusiform aneurysms in humans, due to Model hemodynamic reasons. Arteriovenous fistulae (AVF) are the most December Inhibition of the Akt1-mTORC1 Axis Alters Venous Remodeling to common access created for hemodialysis, 30, 2020 Improve Arteriovenous Fistula Patency but up to 60% do not sustain dialysis within a year, suggesting a ne Atherogenic remodeling often occurs at December The pro-atherogenic response to disturbed blood flow is arterial locations with disturbed blood flow 27, 2019 increased by a western diet, but not by old age (i.e., low or oscillatory) and both aging and western diet (WD) in In vivo characterization of doxycycline-mediated protection of Aortic aneurysm is the most life- December aortic function and structure in a mouse model of Marfan threatening complication in Marfan 14, 2019 syndrome-associated aortic aneurysm syndrome (MFS) patients. SUMOylation of peroxisome proliferator- Negative regulation of eNOS-NO signaling by over-SUMOylation November activated receptor gamma (PPAR γ) of PPARγ contributes to insulin resistance and dysfunction of 01, 2019 plays important regulatory role in its vascular endothelium in rats transcriptional activity. Classic homocystinuria (HCU) is an Behavior, body composition, and vascular phenotype of November inherited disorder characterized by homocystinuric mice on methioninerestricted diet or enzyme 01, 2019 elevated homocysteine (Hcy) in plasma replacement therapy and tissues resulting from cystathionine The mechanisms regulating endothelial November Loss of flow responsive Tie1 results in Impaired Aortic valve cell response to hemodynamic forces 01, 2019 remodeling required for heart valve develop- ment, especially valve remodeling, remain Current perceptions of genetic and “Females Are Not Just ‘Protected’ Males”: Sex-Specific November environmental vulnerabilities in the Vulnerabilities in Placenta and Brain after Prenatal Immune 01, 2019 developing fetus are biased toward male Disruption outcomes. Background: The contentious effects of October Elevated luteinizing hormone contributes to atherosclerosis estrogen therapy on the risk of 01, 2019 formation by inhibiting nitric oxide synthesis via PI3K/Akt pathway postmenopausal cardiovascular disease (CVD) indicate that this type of atherosc The unabated inflammatory response is Regulation of the inflammatory response by vascular grafts October often the cause for inhibited vascular modified with Aspirin-Triggered Resolvin D1 promotes blood 01, 2019 regeneration of transplanted small- vessel regeneration diameter vascular grafts (diameter Macrophage class A1 scavenger receptor October Scavenger receptor A1 attenuates aortic dissection via promoting (SR-A1) is a pattern recognition receptor 01, 2019 efferocytosis in macrophages with an anti-inflammatory feature in cardiovascular diseases.

Aims: Renal interstitial fibrosis and October Pioglitazone downregulates Twist-1 expression in the kidney and glomerulosclerosis are the characteristic 01, 2019 protects renal function of Zucker diabetic fatty rats presentation of diabetic nephropathy progression. Aging is characterized by increased aortic September Increased mitochondrial NADPH oxidase 4 (NOX4) expression in stiffness, an early, independent predictor 01, 2019 aging is a causative factor in aortic stiffening and cause of cardiovascular disease. Objective: Acute limb ischemia (ALI), the August 06, most challenging form of ischemia- Mitochondrial transplantation ameliorates acute limb ischemia 2019 reperfusion injury (IRI) in skeletal muscle tissue, leads to decreased ske Background and aims: Oxidative stress- Z-Ligustilide protects vascular endothelial cells from oxidative May 01, induced endothelial dysfunction is stress and rescues high fat diet-induced atherosclerosis by 2019 considered to exert a vital role in the activating multiple NRF2 downstream genes development of atherosclerotic corona Current in vivo abdominal aortic Strain Mapping From Four-Dimensional Ultrasound Reveals aneurysm (AAA) imaging approaches April 22, Complex Remodeling in Dissecting Murine Abdominal Aortic tend to focus on maximum diameter but 2019 Aneurysms do not measure three-dimensional (3D) vascula Clinical Relevance: Results from this Mas receptor deficiency augments angiotensin II-induced study suggest a novel mode of March 01, atherosclerosis and aortic aneurysm ruptures in intervening in the renin-angiotensin 2019 hypercholesterolemic male mice system to treat vascular diseases, namely, by The embryonic outflow tract (OFT) February Fluid dynamics and forces in the HH25 avian embryonic outflow eventually undergoes aorticopulmonary 27, 2019 tract septation to form the aorta and pulmonary artery, and it is hypothesized that Objective—Abdominal aortic aneurysm is February Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II caused by the accumulation of 01, 2019 (Angiotensin II)–Induced Abdominal Aortic Aneurysm inflammatory cells in the aortic wall. Purpose: Astronauts traveling beyond February Effects of low-dose oxygen ions and protons on cardiac function low-Earth orbit will be exposed to high 01, 2019 and structure in male C57BL/6J mice linear-energy transfer charged particles. Thrombotic diseases rarely cause February Functionalized polymer microbubbles as new molecular symptoms until advanced stage and 01, 2019 ultrasound contrast agent to target P-selectin in thrombus sudden death. Thrombus formed in blood vessel is a February progressive process, which would lead to Recent strategies on targeted delivery of thrombolytics 01, 2019 life-threatening thrombotic diseases such as ischemic stroke. Background. Optimal phosphate control is February Magnesium but not nicotinamide prevents vascular calcification in an unmet need in chronic kidney disease 01, 2019 experimental uraemia (CKD). In the earliest phase of inflammation, January Endothelial signaling by neutrophil-released oncostatin M histamine and other agonists rapidly 22, 2019 enhances P-selectin–dependent inflammation and thrombosis mobilize P-selectin to the apical membranes of endothelial cells, where it Bicuspid aortic valve (BAV) is a common January ROBO4 variants predispose individuals to bicuspid aortic valve congenital heart defect (population 19, 2019 and thoracic aortic aneurysm incidence, 1–2%)1–3 that frequently presents with ascending aortic aneurys Recently, our group demonstrated that January Implantation of VEGF-functionalized cell-free vascular grafts: immobilized VEGF can capture flowing 10, 2019 regenerative and immunological response endothelial cells (ECs) fromthebloodin vitroandpromoteendothelializationand Background . Diabetic retinopathy (DR) is January Scutellarin Prevents Angiogenesis in Diabetic Retinopathy by a serious microvascular complication of 01, 2019 Downregulating VEGF/ERK/FAK/Src Pathway Signaling diabetes. Objective—Arteriovenous fistulae (AVF) January Stimulation of Caveolin-1 Signaling Improves Arteriovenous are the most common access created for 01, 2019 Fistula Patency hemodialysis; however, many AVF fail to mature and require repeated inte Background: Exposure to air pollution and January Fetal growth outcomes following peri-implantation exposure of high levels of noise have both been 01, 2019 Long-Evans rats to noise and ozone differ by sex independently associated with the development of adverse pregnancy outco Children with sickle cell anemia have Age-dependent characterization of the carotid and cerebral artery January elevated stroke risks as well as other morphologies in a transgenic mouse model of sickle cell anemia 01, 2019 arterial complications, but morphological using ultrasound and microcomputed tomography changes to large arteries are n Prenatal exposure to ozone has been January Aspirin pre-treatment modulates ozone-induced fetal growth linked to low birth weight in people and 01, 2019 restriction and alterations in uterine blood flow in rats fetal growth restriction in rats.

Vascular impact of quercetin administration in association with Hyperglycemia and oxidative stress have January moderate exercise training in experimental type 1 diabetes a major role in the pathogenesis of 01, 2019 diabetic vascular complications.

Marfan syndrome (MFS) is a connective January Renal cystic disease in the Fbn1C1039G/+ Marfan mouse is tissue disorder caused by mutations in 01, 2019 associated with enhanced aortic aneurysm formation the fibrillin-1 gene (FBN1), resulting in aortic aneurysm formation and d Fibroblast growth factor 21 (FGF21), a Fibroblast Growth Factor 21 Attenuates Vascular Calcification by January hormone with multiple metabolic Alleviating Endoplasmic Reticulum Stress Mediated Apoptosis in 01, 2019 properties, has proven to be pleiotropic Rats biological effects and may play pivota We hypothesized that NADPH oxidase 4 January The flagellin-TLR5-Nox4 axis promotes the migration of smooth (Nox4) is involved in the formation of 01, 2019 muscle cells in atherosclerosis neointimal atherosclerotic plaques through the migration of smooth muscle Peripheral artery disease is often Assessment of Age-related Oxygenation Changes in Calf Skeletal asymptomatic, and various imaging and January Muscle by Photoacoustic Imaging: A Potential Tool for Peripheral nonimaging techniques have been used 01, 2019 Arterial Disease for assessment and monitoring treatments Background: Endothelial cell injury, Pigment EpithelialDerived Factor Deficiency Accelerates January induced by dyslipidemia, is the initiation Atherosclerosis Development via Promoting Endothelial Fatty 01, 2019 of atherosclerosis, resulting in an Acid Uptake in Mice With Hyperlipidemia imbalance in endothelial fatty aci Hypoxia inducible factor 1α in vascular smooth muscle cells January The process of vascular remodeling is promotes angiotensin II-induced vascular remodeling via 01, 2019 associated with increased hypoxia. activation of CCL7-mediated macrophage recruitment In vivo long-term evaluation of degradable Bilayered Polymeric Micro- and Nanofiber Vascular Grafts as January implants offers valuable information for Abdominal Aorta Replacements: Long-Term in Vivo Studies in a 01, 2019 the further design and optimization of Rat Model biomaterials. Reduced lower-limb blood flow has been January Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation shown to lead to asymmetrical abdominal 01, 2019 in Mice and Humans aortic aneurysms (AAAs) but the mechanism of action is not fully unders Background: Abdominal aortic aneurysm January Cell proliferation detected using [18F]FLT PET/CT as an early (AAA) is a focal aortic dilatation 01, 2019 marker of abdominal aortic aneurysm progressing towards rupture.

The intermediate filament (IF) cytoskeleton has been proposed to January Vimentin regulates Notch signaling strength and arterial regulate morphogenic processes by 01, 2019 remodeling in response to hemodynamic stress integrating the cell fate signaling machinery with Sex-specific differences in endoplasmic reticulum aminopeptidase Salt sensitivity of blood pressure (SSBP) January 1 modulation influence blood pressure and renin-angiotensin and hypertension are common, but the 01, 2019 system responses underlying mechanisms remain unclear. Implanted scaffolds with inductive niches January In vivo engineered extracellular matrix scaffolds with instructive can facilitate the recruitment and 01, 2019 niches for oriented tissue regeneration differentiation of host cells, thereby enhancing endogenous tissue regene Site-specific chelation therapy with EDTA-loaded albumin Medial arterial calcification (MAC) is a January nanoparticles reverses arterial calcification in a rat model of common outcome in diabetes and chronic 01, 2019 chronic kidney disease kidney disease (CKD). Critical limb ischemia is the most serious January Hypoxia-Induced miR-210 Is Necessary for Vascular form of peripheral artery disease, 01, 2019 Regeneration upon Acute Limb Ischemia characterized by severe functional consequences, difficult clinical mana People heterozygous for an activating January Aortic pathology from protein kinase G activation is prevented by mutation in protein kinase G1 (PRKG1, 01, 2019 an antioxidant vitamin B12 analog p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as y Deep vein thrombosis (DVT) is a common January Resolvin D4 attenuates the severity of pathological thrombosis in cardiovascular disease with a major effect 01, 2019 mice on quality of life, and safe and effective therapeutic measures to e MicroRNA-217 attenuates intima–media complex thickness of Background: Little investigation was done December ascending aorta measured by ultrasound bio-microscopy and to test the efficiency of microRNA-217 24, 2018 inhibits inflammation and lipid metabolism in atherosclerotic (miR-217) on atherosclerosis in vivo. models of ApoE−/− mice The heart rate lowering drug Ivabradine December The effect of the heart rate lowering drug Ivabradine on was shown to improve cardiac outcome in 18, 2018 hemodynamics in atherosclerotic mice patients with previous heart failure. BACKGROUND Alcohol abuse and Alcohol Consumption in Combination with an Atherogenic Diet adherence to atherogenic diet (AD; a low- December Increased Indices of Atherosclerosis in Apolipoprotein E/Low carbohydrate-high-protein diet) have 16, 2018 Density Lipoprotein Receptor DoubleKnockout Mice been positively associated with cardiovascu

December Natural killer cells induce neutrophil extracellular trap formation in Summary. 16, 2018 venous thrombosis PURPOSE: Radiation therapy (RT) offers Clarifying the relative impacts of vascular and nerve injury that December an important and curative approach to culminate in erectile dysfunction in a pilot study using a rat model 01, 2018 treating prostate cancer but is associated of prostate irradiation and a thrombopoietin mimetic with a high incidence of erect Background Cluster of differentiation 40 Rosuvastatin stabilizes atherosclerotic plaques by reducing December ligand (CD40L) and rosuvastatin (RSV) CD40L overexpression-induced downregulation of P4Hα1 in 01, 2018 affect atherosclerotic plaque stability, but ApoE−/− mice little is known about thei Endothelial cell derived secretive factors Brg1 trans-activates endothelium-derived colony stimulating factor December play pivotal roles maintaining the to promote calcium chloride induced abdominal aortic aneurysm in 01, 2018 homeostasis by influencing the behaviors mice of other cells. The glucagon-like peptide-1 receptor The GLP-1 Analogs Liraglutide and Semaglutide Reduce December agonists (GLP-1RAs) liraglutide and Atherosclerosis in ApoE−/− and LDLr−/− Mice by a Mechanism 01, 2018 semaglutide reduce cardiovascular risk in That Includes Inflammatory Pathways type 2 diabetes patients. Objectives—Ultrasound biomicroscopy Noninvasive in vivo Assessment of the Re-endothelialization November (UBM), or ultra high-frequency ultra- Process Using Ultrasound Biomicroscopy in the Rat Carotid Artery 13, 2018 sound, is a technique used to assess the Balloon Injury Model anatomy of small research animals. Background Statins reduce aneurysm Statins Reduce Thoracic Aortic Aneurysm Growth in Marfan November growth in mouse models of Marfan Syndrome Mice via Inhibition of the RasInduced ERK 06, 2018 syndrome, although the mechanism is (Extracellular SignalRegulated Kinase) Signaling Pathway unknown. Implanted grafts, including vascular November Biodegradable and elastomeric vascular grafts enable vascular substitutes, inevitably experience 01, 2018 remodeling remodeling by host cells. Considerable insight into effectors of September Combining in vivo and in vitro biomechanical data reveals key cardiovascular function can be gleaned 07, 2018 roles of perivascular tethering in central artery function from controlled studies on mice, especially given the diverse models tha

Introduction: The efficacy of preclinical September A preclinical ultrasound method for the assessment of vascular ultrasound at providing a quantitative 05, 2018 disease progression in murine models assessment of mouse models of vascular disease is relatively unknown. Bone marrow-derived mononuclear cell seeded bioresorbable Background: Acute thrombosis is a September vascular graft improves acute graft patency by inhibiting thrombus crucial cause of bioresorbable vascular 01, 2018 formation via platelet adhesion graft (BVG) failure. Ultra High Frequency Ultrasound July 31, Fast Vessel Segmentation and Tracking in Ultra High-Frequency (UHFUS) enables the visualization of 2018 Ultrasound Images. highly deformable small and medium vessels in the hand. There is no therapy that promotes July 18, The Murine Dialysis Fistula Model Exhibits a Senescence maturation and functionality of a dialysis 2018 Phenotype: Pathobiologic Mechanisms and Therapeutic Potential arteriovenous fistula (AVF). BACKGROUND: Hypoxia within acute July 01, Inhibition of prolyl hydroxylase domain proteins selectively venous thrombi is thought to drive 2018 enhances venous thrombus neovascularisation resolution through stabilisation of hypoxia inducible factor 1 alpha (HIF1α). We previously developed a tissue- engineered vascular graft (TEVG)made June 15, Angiotensin II receptor I blockade prevents stenosis of tissue by seeding autologous cells onto a 2018 engineered vascular grafts biodegradable tubular scaffold, in anattempt Venous thromboembolism (VTE) is a June 12, The endothelial tumor suppressor p53 is essential for venous leading cause of morbidity and mortality 2018 thrombus formation in aged mice in elderly people. Pulmonary embolism (PE) results from Pulmonary Arterial Hypertension and Endothelial Dysfunction Is June 10, deep vein thrombosis (DVT) and can lead Linked to NADPH Oxidase-Derived Superoxide Formation in 2018 to chronic thromboembolic pulmonary Venous Thrombosis and Pulmonary Embolism in Mice hypertension (CTEPH) involving vascul May 24, Perivascular Adipose Tissue-Derived PDGF-D Contributes to Obesity increases the risk of vascular 2018 Aortic Aneurysm Formation during Obesity diseases, including aortic aneurysm (AA). Abdominal aortic aneurysms (AAAs) are May 18, Ginkgo biloba extracts prevent aortic rupture in angiotensin II- a chronic vascular disease characterized 2018 infused hypercholesterolemic mice by pathological luminal dilation.

Diabetes is a negative risk factor for aortic April 01, Diabetes Reduces Severity of Aortic Aneurysms Depending on aneurysm, but the underlying explanation 2018 the Presence of Cell Division Autoantigen 1 (CDA1) for this phenomenon is unknown. Moderate anemia is associated with April 01, Red blood cell antibody-induced anemia causes differential increased mortality and morbidity, 2018 degrees of tissue hypoxia in kidney and brain including acute kidney injury (AKI), in surgical patients. The large-conductance voltage- and Ca 2+ -activated K + channel The uterine artery (UA) markedly March 15, and its γ1-subunit modulate mouse uterine artery function during vasodilates during pregnancy to direct 2018 pregnancy blood flow to the developing fetus. MicroRNA-21 Knockout Exacerbates Angiotensin II–Induced Objective—Thoracic aortic aneurysm and March 08, Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal dissection (TAAD) are severe vascular 2018 Transforming Growth Factor-β–SMAD3 Signaling conditions. Minoxidil improves vascular compliance, restores cerebral blood Increased vascular stiffness correlates March 02, flow and alters extracellular matrix gene expression in a model of with higher risk of cardiovascular 2018 chronic vascular stiffness complications in aging adults. Calcific aortic vasculopathy correlates February Effects of teriparatide on morphology of aortic calcification in aged with bone loss in osteoporosis in an age- 16, 2018 hyperlipidemic mice independent manner. Assessments of the appropriateness and In vitro photoacoustic spectroscopy of pulsatile blood flow: February inappropriateness of behaviors may probing the interrelationship between red blood cell aggregation 12, 2018 influence conflict, cohesion, and goal and oxygen saturation attainment in multinational organizat Here, we tested the hypothesis that January Pulmonary vascular dysfunction secondary to pulmonary arterial severe pulmonary arterial hypertension 18, 2018 hypertension: Insights gained through retrograde perfusion impairs retrograde perfusion. Low and disturbed blood flow drives the January Alternative RNA splicing in the endothelium mediated in part by progression of arterial diseases including 02, 2018 Rbfox2 regulates the arterial response to low flow atherosclerosis and aneurysms. Original Research Systemic Upregulation Systemic Upregulation of IL-10 (Interleukin-10) Using a of IL-10 (Interleukin-10) Using a January Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Nonimmunogenic Vector Reduces 01, 2018 Abdominal Aortic Aneurysm Growth and Rate of Dissecting Abdominal Aortic Increased placental T cell trafficking results in adverse January Interleukin-1 beta (IL-1β) is a cytokine neurobehavioral outcomes in offspring exposed to sub-chronic 01, 2018 mediator of perinatal brain injury. maternal inflammation Notoginsenoside R1, a unique constituent Notoginsenoside R1, a unique constituent of Panax notoginseng, January from the root of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac 01, 2018 exerts anti-inflammatory, anti-oxidative hypertrophy in ApoE-/- mice and anti-apoptotic properties. OBJECTIVE: Plaque erosion is increasing January Lipid-Lowering Therapy With Ezetimibe Decreases Spontaneous its importance as one of the mechanisms 01, 2018 Atherothrombotic Occlusions in a Rabbit Model of Plaque Erosion of acute coronary syndromes in this statin era. © 2018 Springer-Verlag GmbH Germany, Angiotensin-(1-7)-induced Mas receptor activation attenuates January part of Springer Nature Angiotensin atherosclerosis through a nitric oxide-dependent mechanism in 01, 2018 (Ang)-(1-7) ameliorates vascular injury by apolipoproteinE-KO mice increasing nitric oxide (NO) bioav Increased Calcific Aortic Valve Disease in response to a Objective: Calcific aortic valve disease January diabetogenic, procalcific diet in the LDLr-/-ApoB100/100mouse (CAVD) is a major cause of aortic 01, 2018 model stenosis (AS) and cardiac insufficiency. Cardiorespiratory fitness (CRF) inversely Glucagon-like peptide-1 receptor antagonism impairs basal January predicts cardiovascular (CV) mortal- ity exercise capacity and vascular adaptation to aerobic exercise 01, 2018 and CRF is impaired in people with type 2 training in rats diabetes (T2D). Thoracic aortic dissection (TAD) is an January Identification of type IV collagen exposure as a molecular imaging aggressive and life-threatening vascular 01, 2018 target for early detection of thoracic aortic dissection disease and there is no effective means of early diagnosis of dissecti © 2018 The Author(s). The role of January Lack of T-bet reduces monocytic interleukin-12 formation and leukocytes in deep vein thrombosis (DVT) 01, 2018 accelerates thrombus resolution in deep vein thrombosis resolution is incompletely understood. Super-resolution imaging methods January Motion model ultrasound localization microscopy for preclinical promote tissue characterization beyond 01, 2018 and clinical multiparametric tumor characterization the spatial resolution limits of the devices and bridge the gap between histop Proponents for electronic cigarettes(E- cigs) claim they are a safe alternative to January Chronic exposure to electronic cigarette (E-cig) results in impaired smoking tobacco-based 01, 2018 cardiovascular function in mice cigarettes,however little is known about the l There is a growing body of research on January Sympathetic Neuronal Activation Triggers Myeloid Progenitor the neural control of immunity and 01, 2018 Proliferation and Differentiation inflammation. Hypertension is associated with January Alterations of Ocular Hemodynamics Impair Ophthalmic Vascular numerous diseases, but its direct impact 01, 2018 and Neuroretinal Function on the ocular circulation and neuroretinal function remains unclear. Abdominal aortic aneurysm (AAA) has high mortality rate when ruptured, but January Protein-1 ) in Smooth Muscle Cells Protects Mice From currently, there is no proven 01, 2018 Abdominal Aortic Aneurysms pharmacological therapy for AAA because of ou The apolipoprotein E-deficient ( apoE –/– January Angiotensin II Infusion Does Not Cause Abdominal Aortic ) mouse model has advanced our 01, 2018 Aneurysms in Apolipoprotein E-Deficient Rats understanding of cardiovascular disease mechanisms and experimental therapeut Inhibition of endoplasmic reticulum stress by intermedin1-53 Endoplasmic reticulum stress (ERS) is January attenuates angiotensin II–induced abdominal aortic aneurysm in involved in the development of abdominal 01, 2018 ApoE KO Mice aortic aneurysm (AAA). January Elevated 20-HETE in metabolic syndrome regulates arterial Arterial stiffness plays a causal role in 01, 2018 stiffness and systolic hypertension via MMP12 activation development of systolic hypertension. Autologous veins are the most widely January A biodegradable synthetic graft for small arteries matches the used grafts for bypassing small arteries in 01, 2018 performance of autologous vein in rat carotid arteries coronary and peripheral arterial occlusive diseases. Growth and remodeling of the primitive January Cohort-based multiscale analysis of hemodynamic-driven growth pharyngeal arch artery (PAA) network into 01, 2018 and remodeling of the embryonic pharyngeal arch arteries the extracardiac great vessels is poorly understood but a major sourc Ganoderma mushrooms, used in Ganoderma Triterpenoids Exert Antiatherogenic Effects in Mice by traditional Chinese medicine to promote January Alleviating Disturbed Flow-Induced Oxidative Stress and health and longevity, have become widely 01, 2018 Inflammation accepted as herbal supplements.

A context-specific cardiac β-catenin and GATA4 interaction Chromatin remodelling precedes January influences TCF7L2 occupancy and remodels chromatin driving transcriptional and structural changes in 01, 2018 disease progression in the adult heart heart failure. Background: Post-infarction cardiovascular remodeling and heart January Gut-dependent microbial translocation induces inflammation and failure are the leading cause of 01, 2018 cardiovascular events after ST-elevation myocardial infarction myocardial infarction (MI)-driven death during the pa BACKGROUND: Bronchopulmonary Upregulation of Vascular Endothelial Growth Factor in Amniotic January dysplasia (BPD) is a chronic lung disease Fluid Stem Cells Enhances Their Potential to Attenuate Lung 01, 2018 that affects extremely preterm infants and Injury in a Preterm Rabbit Model of Bronchopulmonary Dysplasia remains - despite improvements in ne January The chronic complex stress combined atherogenic diet The effects of stress on the 01, 2018 accelerates the process of atherosclerosis in mice atherosclerosis are complex. There are indications for elevated CXCL8 January CXCL8 hyper-signaling in the aortic abdominal aneurysm levels in abdominal aortic aneurysm 01, 2018 disease (AAA). OBJECTIVE Two were the aims of this January Cell Type–Specific Contributions of the Angiotensin II Type 1a study: first, to translate whole-genome 01, 2018 Receptor to Aorta Homeostasis and Aneurysmal Disease expression profiles into computational predictions of functional associati Background: Studies indicate that Chemokine CC-motif ligand 2 participates in platelet function and January chemokine CC-motif ligand 2 (CCL2) is arterial thrombosis by regulating PKCα-P38MAPK-HSP27 01, 2018 involved in inflammation and pathway atherosclerosis. Intrauterine growth restriction (IUGR) is a Simultaneous ablation of uterine natural killer cells and uterine January serious pregnancy complication with mast cells in mice leads to poor vascularization and abnormal 01, 2018 short- and long-term health doppler measurements that compromise fetal well-being consequences. Abstract: In this study, we tested the January Rho Kinase Inhibitor , Fasudil , Attenuates Contrast-induced Acute hypothesis that fasudil, a Rho kinase 01, 2018 Kidney Injury inhibitor, would protect against contrast- induced acute kidney injury (CI

Background: High-dose radiotherapy (>8- January Role of Acid Sphingomyelinase and Ceramide in Mechano- 10 Gy) causes rapid endothelial cell death 01, 2018 Acoustic Enhancement of Tumor Radiation Responses via acid sphingomyelinase (ASMase)- induced ceramide production, resu January The complement C3a-C3aR axis promotes development of © 2018 by The American Association of 01, 2018 thoracic aortic dissection via regulation of MMP2 expression Immunologists, Inc. All rights reserved. As photoacoustic (PA) imaging makes its January Improved photoacoustic-based oxygen saturation estimation with way into the clinic, accuracy of PA-based 01, 2018 SNR-regularized local fluence correction metrics becomes increasingly important. Aims:Despite vast clinical experience In vivo inhibition of nuclear factor of activated T-cells leads to January linking diabetes and atherosclerosis, the atherosclerotic plaque regression in IGF-II/LDLR –/– ApoB 01, 2018 molecular mechanisms leading to 100/100 mice accelerated vascular damage are still OBJECTIVE/BACKGROUND: Abdominal Four Surgical Modifications to the Classic Elastase Perfusion January aortic aneurysm (AAA) is an individual Aneurysm Model Enable Haemodynamic Alterations and 01, 2018 and socioeconomic burden in today's Extended Elastase Perfusion ageing society. Background Heated tobacco products January Vascular endothelial function is impaired by aerosol from a single (also called ‘heat-not-burn’ products) heat 01, 2018 IQOS HeatStick to the same extent as by cigarette smoke tobacco at temperatures below that of combustion, causing nicotine and Venous thrombosis is a common January Deep Vein Thrombosis Induced by Stasis in Mice Monitored by condition affecting 1 - 2% of the 01, 2018 High Frequency Ultrasonography. population, with an annual incidence of 1 in 500. Wall shear stress (WSS) is involved in January Temporal and spatial changes in wall shear stress during atherosclerotic plaque initiation, yet its 01, 2018 atherosclerotic plaque progression in mice role in plaque progression remains unclear. Atherosclerosis is characterized by the January Copper sulfide nanoparticles as a photothermal switch for TRPV1 accumulation of lipids within the arterial 01, 2018 signaling to attenuate atherosclerosis wall. Aging is the largest risk factor for January Restoring mitochondrial DNA copy number preserves cardiovascular disease, yet the molecular 01, 2018 mitochondrial function and delays vascular aging in mice mechanisms underlying vascular aging remain unclear.

Objective: The purpose of this study was January Rapamycin prevents thoracic aortic aneurysm and dissection in to investigate whether rapamycin inhibits 01, 2018 mice the development of thoracic aortic aneurysm and dissection (TAAD) i In the field of vascular graft research, Vascular Remodeling Process of Heparin-Conjugated Poly(ε- January poly-ε-caprolactone (PCL) is used owing Caprolactone) Scaffold in a Rat Abdominal Aorta Replacement 01, 2018 to its good mechanical strength and Model biocompatibility. The mechanisms that regulate H2A.Z and January Transcriptional regulation mediated by H2A.Z via ANP32e- its requirement for transcription in 01, 2018 dependent inhibition of protein phosphatase 2A differentiated mammalian cells remains ambiguous. Obesity in a mouse model leads to Diet-induced obesity alters the maternal metabolome and early January alterations in the maternal metabolome placenta transcriptome and decreases placenta vascularity in the 01, 2018 and early placenta transcriptome as well mouse as changes in vascularity later in g Background: Persistent fetal vasculature December Large is required for normal astrocyte migration and retinal (PFV) is a congenital developmental 17, 2017 vasculature development anomaly of the eye that accounts for about 5% of childhood blindness. Background: The Hippo signaling December The Hippo signaling pathway: a potential therapeutic target is pathway is reported to be involved in 04, 2017 reversed by a Chinese patent drug in rats with diabetic retinopathy angiogenesis, but the roles of the Hippo pathway in diabetic retinopathy have no Aim: Surgical management of pediatric December Novel application and serial evaluation of tissue-engineered portal extrahepatic portal vein obstruction 01, 2017 vein grafts in a murine model requires meso-Rex bypass using autologous or synthetic grafts. Angiogenic growth factor therapy for August 10, Sustained Placental Growth Factor-2 Treatment Does Not ischemic cardiovascular disease carries a 2017 Aggravate Advanced Atherosclerosis in Ischemic Cardiomyopathy risk of stimulating atherosclerotic plaque growth. Background. Marfan syndrome (MFS) August 01, A Novel Murine Model of Marfan Syndrome Accelerates represents a genetic disorder with 2017 Aortopathy and Cardiomyopathy variable phenotypic expression. A thrombus (blood clot) is formed in June 27, Fibrin-Targeted and H 2 O 2 -Responsive Nanoparticles as a injured vessels to maintain the integrity of 2017 Theranostics for Thrombosed Vessels vasculature. OBJECTIVE: Electrospinning is a June 13, Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber promising technology that provides 2017 Vascular Grafts biodegradable nanofiber scaffolds for cardiovascular tissue engineering. RATIONALE Mutations in ACTA2, Loss of Smooth Muscle α-Actin Leads to NF-κB–Dependent June 09, encoding the smooth muscle isoform of Increased Sensitivity to Angiotensin II in Smooth Muscle Cells and 2017 α-actin, cause thoracic aortic aneurysms, Aortic EnlargementNovelty and Significance acute aortic dissections, and occlusive Loss of MURC/Cavin-4 induces JNK and MMP-9 activity Abdominal aortic aneurysm (AAA) is June 01, enhancement in vascular smooth muscle cells and exacerbates relatively common in elderly patients with 2017 abdominal aortic aneurysm atherosclerosis. Arteries for bypass grafting are harvested June 01, Reduced arterial elasticity due to surgical skeletonization is either with neighboring tissue attached or 2017 ameliorated by abluminal PEG hydrogel as skeletonized vessels that are free of surrounding tissue. The aim of the present study was to June 01, Establishment and evaluation of a reversible two-kidney, one-clip establish and evaluate a novel and 2017 renovascular hypertensive rat model reversible two-kidney, one-clip renovas- cular hypertensive rat model with a ti Postmenopausal hormone replacement May 09, Effect of chronic estradiol plus progesterone treatment on therapy (HRT) with estrogen plus 2017 experimental arterial and venous thrombosis in mouse progestogens is the first line therapy to treat menopausal symptoms. Objective—Williams syndrome is Deficient Circumferential Growth Is the Primary Determinant of May 02, characterized by obstructive aortopathy Aortic Obstruction Attributable to Partial Elastin 2017 attributable to heterozygous loss of ELN, DeficiencyHighlights the gene encoding elastin. The identity of the specific nitric oxide April 10, Cytoglobin regulates blood pressure and vascular tone through dioxygenase (NOD) that serves as the 2017 nitric oxide metabolism in the vascular wall main in vivo regulator of O2-dependent NO degradation in smooth muscle Objective: Angiotensin (Ang) II type 1 April 01, Inhibition or deletion of angiotensin II type 1 receptor suppresses receptor (AT1) activation is essential for 2017 elastase-induced experimental abdominal aortic aneurysms the development of exogenous Ang II- induced abdominal aortic aneurys Aortic root aneurysm formation and April 01, Longterm miR29b suppression reduces aneurysm formation in a subsequent dissection and/or rupture 2017 Marfan mouse model remain the leading cause of death in patients with Marfan syndrome. Epoetin beta pegol ameliorates flow-mediated dilation with BACKGROUND/AIMS: Patients with April 01, improving endothelial nitric oxide synthase coupling state in diabetic nephropathy have a high 2017 nonobese diabetic rats cardiovascular mortality. Endothelial cell (EC) dysfunction is March 29, Development of a Glycosaminoglycan Derived, Selectin Targeting associated with many disease states 2017 Anti-Adhesive Coating to Treat Endothelial Cell Dysfunction including deep vein thrombosis (DVT), chronic kidney disease, sepsis and diab Vascular remodeling during chronic Chronic PARP-1 inhibition reduces carotid vessel remodeling and March 24, hypertension may impair the supply of oxidative damage of the dorsal hippocampus in spontaneously 2017 tissues with oxygen, glucose and other hypertensive rats compounds, potentially unleashing dele miR-155 is one of the most important March 09, A comparative study of the characterization of miR-155 in miRNAs and plays a very important role 2017 knockout mice in numerous biological processes. Abdominal aortic aneurysms (AAAs) March 01, Murine ultrasound-guided transabdominal para-aortic injections of represent a potentially life-threatening 2017 self-assembling type I collagen oligomers condition that predominantly affects the infrarenal aorta. Nox4-based NADPH oxidase is a major March 01, Endothelial Nox4-based NADPH oxidase regulates reactive oxygen species-generating 2017 atherosclerosis via soluble epoxide hydrolase enzyme in the vasculature, but its role in atherosclerosis remains controversia Off the shelf scaffolds for replacing ultra- February Dual-acting biofunctionalised scaffolds for applications in small diameter vascular grafts are 20, 2017 regenerative medicine valuable for reconstruction of diseased or damaged vessels. Deletion of Hypoxia-Inducible Factor-1α in Myeloid Lineage Hypoxia-inducible factor (HIF)-1α is a February Exaggerates Angiotensin II-Induced Formation of Abdominal transcription factor that regulates various 14, 2017 Aortic Aneurysm genes responding to hypoxic conditions. Arterial stiffness can be evaluated by February calculating pulse wave velocity (PWV), Ultrasound-based Pulse Wave Velocity Evaluation in Mice 14, 2017 i.e., the speed with which the pulse wave travels in a conduit vessel. Increased production of methylglyoxal February Dual effects of fructose on ChREBP and FoxO1/3α are (MG) in vascular tissues is one of the 01, 2017 responsible for AldoB up-regulation and vascular remodelling causative factors for vascular remodeling in different subtypes of metabo BACKGROUND: The poor clinical results that are frequently reported for February Increased Oxidative Stress and Hypoxia Inducible Factor-1 arteriovenous fistulae (AVF) for 01, 2017 Expression during Arteriovenous Fistula Maturation hemodialysis are typically due to failure of A Photoacoustic imaging has emerged as a promising technique to improve February In vivo photoacoustic lipid imaging in mice using the second near- preclinical and clinical imaging by 01, 2017 infrared window providing users with label-free optical cont

Female Mice With an XY Sex Chromosome Complement Develop Background—Abdominal aortic January Severe Angiotensin II–Induced Abdominal Aortic aneurysms (AAAs) are a deadly 24, 2017 AneurysmsClinical Perspective pathology with strong sexual dimorphism. Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Orofacial clefting is amongst the most January Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in common of birth defects, with both 12, 2017 Humans and Mice genetic and environmental components. Heritable thoracic aortic aneurysms and Nitric oxide mediates aortic disease in mice deficient in the January dissections (TAAD), including Marfan metalloprotease Adamts1 and in a mouse model of Marfan 09, 2017 syndrome (MFS), currently lack a cure, syndrome and causative mutations have been Background: The NR4A3 orphan nuclear Deletion of the NR4A nuclear receptor NOR1 in hematopoietic January hormone receptor, NOR1, functions as a stem cells reduces inflammation but not abdominal aortic 01, 2016 constitutively active transcription factor to aneurysm formation regulate inflammation, proli Pentaerythritol tetranitrate (PETN) in-vivo treatment improves Objective: Oxidative stress and January oxidative stress and vascular dysfunction by suppression of endothelial dysfunction contribute to 01, 2016 endothelin-1 signaling in monocrotaline-induced pulmonary pulmonary arterial hypertension (PAH). hypertension Angiogenesis inhibitors are important for January Differential Effects of EGFL6 on Tumor versus Wound cancer therapy, but clinically approved 01, 2016 Angiogenesis anti-angiogenic agents have shown only modest efficacy and can compr Background MR-angiography currently In vivo MR-angiography for the assessment of aortic aneurysms January represents one of the clinical reference- in an experimental mouse model on a clinical MRI scanner: 01, 2016 standards for the assessment of aortic- Comparison with high-frequency ultrasound and histology dimensions. Background: Remote Ischemic Preconditioning (rIPC) and the January Effects of Rotigaptide and RIC on Ischemia Reperfusion Injury in antiarrhythmic peptide analogue, 01, 2016 the In Vitro Rabbit Heart Rotigaptide (ZP123), protects against myocardial ischemia- Abdominal aortic aneurysm (AAA) is a January Cortistatin attenuates angiotensin II-induced abdominal aortic fatal disease that is associated with 01, 2016 aneurysm through inactivation of the ERK1/2 signaling pathways chronic inflammation in the vessel wall.

Aims Elevation of arginase activity has January Obesity-induced vascular dysfunction and arterial stiffening been linked to vascular dysfunction in 01, 2016 requires endothelial cell arginase 1 diabetes and hypertension by a mechanism involving decreased nitric oxi Characterization of age-related penile microvascular Current technology for penile January hemodynamic impairment using laser speckle contrast imaging: hemodynamic evaluations in small 01, 2016 Possible role of increased fibrogenesis animals is invasive and has limitations. Objective: The pathophysiologic January Loss of vascular smooth muscle cell autophagy exacerbates processes of abdominal aortic aneurysms 01, 2016 angiotensin II-associated aortic remodeling (AAAs) and atherosclerosis often intersect. Vascular calcification is a risk factor that January Dietary potassium regulates vascular calcification and arterial predicts adverse cardiovascular 01, 2016 stiffness complications of several diseases including atherosclerosis. Marfan syndrome (MFS) is a connective January Aortic microcalcification is associated with elastin fragmentation in tissue disorder in which aortic rupture is 01, 2016 Marfan syndrome the major cause of death. A thrombus (blood clot), composed Molecularly Engineered Theranostic Nanoparticles for January mainly of activated platelets and fibrin, Thrombosed Vessels: H2O2-Activatable Contrast-Enhanced 01, 2016 obstructs arteries or veins, leading to Photoacoustic Imaging and Antithrombotic Therapy various life-threatening diseases. Background: Moderate hyperhomocysteinemia is an attractive January Moderately Elevated Homocysteine Does Not Contribute to target for intervention because it is 01, 2016 Thoracic Aortic Aneurysm in Mice present in 5-7% of the population and can be reversed Background: Prenatal alcohol exposure (PAE) can result in physical and January Fetal Alcohol Exposure Alters Blood Flow and Neurological neurocognitive deficits that are 01, 2016 Responses to Transient Cerebral Ischemia in Adult Mice collectively termed “fetal alcohol spectrum di Background/Aims: The renal resistive January Renal Resistive Index as a Novel Indicator for Renal index (RI) is a novel candidate as a renal 01, 2016 Complications in High-Fat Diet-Fed Mice injury prognostic indicator, but it remains unclear how renal RI level A method for computer-aided assessment January Computer-Aided Evaluation of Blood Vessel Geometry From of blood vessel geometries based on 01, 2016 Acoustic Images shape-fitting algorithms from metric vision was evaluated. Uridine adenosine tetraphosphate (Up 4 January Divergent coronary flow responses to uridine adenosine A) exerts potent relaxation in porcine 01, 2016 tetraphosphate in atherosclerotic ApoE knockout mice coronary arteries that is reduced following myocardial infarction, sugge

An ascending aortic aneurysm (AscAA) is January Notch1 haploinsufficiency causes ascending aortic aneurysms in a life-threatening disease whose 01, 2016 mice. molecular basis is poorly understood. Protein disulfide isomerase (PDI) present January HPW-RX40 prevents human platelet activation by attenuating cell at platelet surfaces has been considered 01, 2016 surface protein disulfide isomerases to play an important role in the conformational change and activati Collagen External Scaffolds Mitigate Intimal Hyperplasia and January Improve Remodeling of Vein Grafts in a Rabbit Arteriovenous Objectives . 01, 2016 Graft Model Biodegradable gelatin hydrogel sheet Suppression of aortic expansion and contractile recovery in a rat January (BGHS) incorporating basic fibroblast abdominal aortic aneurysm model by biodegradable gelatin 01, 2016 growth factor (bFGF) may inhibit the pro- hydrogel sheet incorporating basic fibroblast growth factor gression of abdominal aortic aneu Effective therapies for preventing January Intravascular application of electrocautery in a rabbit model of perioperative complications such as 01, 2016 abdominal aortic endarterectomy thrombosis and inflammation after coro- nary endarterectomy (CE) are lacking. Background/Aims Studies of human Possible type 1 diabetes risk prediction: Using ultrasound imaging cadaveric pancreas specimens indicate January to assess pancreas inflammation in the inducible autoimmune that pancreas inflammation plays an 01, 2016 diabetes BBDR model important role in type 1 diabetes pathogene Background/Purpose: The aim of this Non-invasive longitudinal monitoring of angiogenesis in a murine January study was to evaluate the longitudinal full-thickness cutaneous wound healing model using high- 01, 2016 monitoring of angiogenesis in a murine resolution three-dimensional ultrasound imaging full- thickness cutaneous wound heal BACKGROUND Trimethylamine-N-oxide Trimethylamine-N-oxide induces vascular inflammation by January (TMAO) has recently been identified as a activating the NLRP3 inflammasome through the SIRT3-SOD2- 01, 2016 novel and independent risk factor for mtROS signaling pathway promoting atherosclerosis through ind Although Roux-en-Y Gastric Bypass January Customization of bilio-pancreatic limb length to modulate and (RYGB) remains the most effective 01, 2016 sustain anti-diabetic effect of gastric bypass surgery treatment for obesity and type 2 diabetes (T2D), many patients fail to achieve rem

Aims Angiotensin II-infused ApoE-/- mice January Angiotensin II infusion into ApoE-/- mice: a model for aortic are a popular mouse model for preclinical 01, 2016 dissection rather than abdominal aortic aneurysm? aneurysm research. Thrombosis is a main cause of acute January Photoacoustic Imaging: A Novel Tool for Detecting Carotid Artery cardiovascular events, and detecting 01, 2016 Thrombosis in Mice thrombi in small arteries via noninvasive im- aging remains challenging. A method is explored for increasing the January Expanding Acquisition and Clutter Filter Dimensions for Improved sensitivity of power-Doppler imaging 01, 2016 Perfusion Sensitivity without contrast enhancement. To date, no studies have explored the Original Research: Feasibility and safety of two surgical January effect of abnormal cerebral venous techniques for the development of an animal model of jugular vein 01, 2016 circulation on brain disorders, whereas occlusion many studies have investigated neurod Rationale: Although not fully understood, January Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic the phenotypic transition of vascular 01, 2016 Aneurysm Formation via FoxO4 Interaction smooth muscle cells exhibits at the early onset of the pathology of ao Low rates of arteriovenous fistula (AVF) January Eph-B4 regulates adaptive venous remodeling to improve maturation prevent optimal fistula use for 01, 2016 arteriovenous fistula patency hemodialysis; however, the mechanism of venous remodeling in the f PURPOSE: The upregulation of vascular Monitoring inflammation injuries in the progression of January cell adhesion molecule-1(VCAM-1) on atherosclerosis with contrast enhanced ultrasound molecular 01, 2016 vascular endothelium plays a great role in imaging the progression of atherosclerosi Decorin (DCN) is a small-leucine rich January Recombinant Decorin Fusion Protein Attenuates Murine proteoglycan that mediates collagen 01, 2016 Abdominal Aortic Aneurysm Formation and Rupture fibrillogenesis, organization, and tensile strength. Consumption of a high-fat, high-sugar diet January High-Fat, High-Sugar Diet-Induced Subendothelial Matrix and sedentary lifestyle are correlated with 01, 2016 Stiffening is Mitigated by Exercise bulk arterial stiffening. Recent advances in the field of innate January Toll-like receptor-4 signaling pathway in aorta aging and diseases: immunity have revealed a complex role of 01, 2016 “its double nature” innate immune signaling pathways in both tissue homeostasis and diseas Aortic aneurysms are life-threatening January Targeting Interleukin-1β Protects from Aortic Aneurysms Induced conditions with effective treatments 01, 2016 by Disrupted Transforming Growth Factor β Signaling mainly limited to emergency surgery or trans-arterial endovascular stent gr

Background The pathophysiology of January Altered Penile Caveolin Expression in Diabetes: Potential Role in increased severity of erectile dysfunction 01, 2016 Erectile Dysfunction in men with diabetes and their poor response to oral pharmacotherapy are Each year, hundreds of thousands January Improving in vivo outcomes of decellularized vascular grafts via coronary bypass procedures are 01, 2016 incorporation of a novel extracellular matrix performed in the US, yet there currently exists no off-the-shelf alternative to autolo Deficiency of CCAAT/enhancer-binding protein homologous January Aortic valve (AoV) calcification is common protein (CHOP) prevents diet-induced aortic valve calcification in 01, 2016 in aged populations. vivo Increasing evidence suggests Oral chromium picolinate impedes hyperglycemia-induced thrombospondin-1 (TSP-1), a potent January atherosclerosis and inhibits proatherogenic protein TSP-1 proatherogenic matricellular protein, as a 01, 2016 expression in STZ-induced type 1 diabetic ApoE -/- mice putative link between hyperglycemia and ath Background-DBZ (Danshensu Bingpian DBZ (Danshensu Bingpian Zhi), a novel natural compound January Zhi), a synthetic derivative of a natural derivative, attenuates atherosclerosis in apolipoprotein E-Deficient 01, 2016 compound found in traditional Chinese mice medicine, has been reported to supp Serotonin [5-hydroxytryptamine (5-HT)] January causes relaxation of the isolated superior 5-HT causes splanchnic venodilation 01, 2016 mesenteric vein, a splanchnic blood vessel, through activation of th BACKGROUND Transradial coronary Comparison of very-high-frequency ultrasound assessment of January procedure (TRP) traumatizes the radial radial arterial wall layers after first and repeated transradial 01, 2016 artery (RA), especially resulting in coronary procedures changes to arterial wall morphology. Framingham Heart Study suggests that December SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female dysfunction of steroid receptor 22, 2016 Mice coactivator-1 may be involved in the development of hypertension. Several erythropoietin-producing December The role of GRIP1 and ephrin B3 in blood pressure control and hepatocellular receptor B family (EPHB) 12, 2016 vascular smooth muscle cell contractility and their ligands, ephrinBs (EFNBs), are involved in blood pressure regulatio December Mouse models of deep vein thrombosis 12, 2016 Maternal vascular responses to hypoxia Maternal vascular responses to hypoxia in a rat model of December in a rat model of intrauterine growth intrauterine growth restriction 01, 2016 restriction.

Preeclampsia is a hypertensive disorder December Serelaxin improves the pathophysiology of placental ischemia in of pregnancy with limited therapeutic 01, 2016 the reduced uterine perfusion pressure rat model of preeclampsia options. A pH-responsive microbubble-eluting December Smart Microbubble Eluting Theranostic Stent for Noninvasive theranostic stent is developed for real- 01, 2016 Ultrasound Imaging and Prevention of Restenosis time ultrasound imaging of stent implanted blood vessels and dissolution o Intrauterine growth restriction (IUGR) November Intrauterine Growth Restriction Influences Vascular Remodeling increases the incidence of adult 23, 2016 and Stiffening in the Weanling Rat More than Sex or Diet cardiovascular disease (CVD). Photoacoustic (PA) imaging is an emerging technology that combines November Photoacoustic Imaging for the Detection of Hypoxia in the Rat structural and functional imaging of 11, 2016 Femoral Artery and Skeletal Muscle Microcirculation tissues using laser and ultrasound energy. Marfan syndrome (MFS) is an autosomal- Aortic and Cardiac Structure and Function Using High-Resolution November dominant disorder of connective tissue Echocardiography and Optical Coherence Tomography in a 08, 2016 caused by mutations in the fibrillin-1 Mouse Model of Marfan Syndrome (FBN1) gene. Disturbed blood flow (d-flow) induces Functional screening of mammalian mechanosensitive genes November atherosclerosis by altering the expression using Drosophila RNAi library– Smarcd3/Bap60 is a 07, 2016 of mechanosensitive genes in the arterial mechanosensitive pro-inflammatory gene endothelium. November Hepatic infarcts or abscesses occur after in a Rat Model 02, 2016 hepatic artery interruption. Mucopolysaccharidosis type I (MPS IH) is October Angiotensin receptor blockade mediated amelioration of a lyso- somal storage disease (LSD) 14, 2016 mucopolysaccharidosis type I cardiac and craniofacial pathology caused by inactivating mutations to the alpha-L-iduronidase (IDUA) gene. Transforming growth factor (TGF)-β October Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic signaling disorder has emerged as a 14, 2016 aneurysm formation by stimulating multiple signaling events common molecular signature for aortic aneurysm development. The present study investigated the contribution of bone marrow-derived October Endothelial-like cells differentiated from mesenchymal stem cells mesenchymal stem cells (BM-MSCs) to 05, 2016 attenuate neointimal hyperplasia after vascular injury neointimal formation, and whether endotheli

Rationale: Immune cells play an important October Innate Effector-Memory T Cell Activation Regulates Post- role during the generation and resolution 05, 2016 Thrombotic Vein Wall Inflammation and Thrombus Resolution of thrombosis. Abstract The arterial structure cyclically October Asymmetric pulsation of rat carotid artery bifurcation in three- fluctuates in three-dimensions (3-D) 04, 2016 dimension observed by ultrasound imaging caused by pulsatile blood flow. Hyperhomocysteinemia (HHcy) has been October Toll-like receptor 4 mutation suppresses hyperhomocysteinemia- observed to promote hypertension, but 01, 2016 induced hypertension the mechanisms are unclear. Pathologic vascular adaptation following September Hemodynamic Influence on Smooth Muscle Cell Kinetics and local injury is the primary driver for 13, 2016 Phenotype During Early Vein Graft Adaptation accelerated intimal hyper- plasia and an occlusive phenotype. Calcific aortic valve disease (CAVD) is September Matrix metalloproteinase inhibitor, doxycycline and progression of the most common cause of aortic 13, 2016 calcific aortic valve disease in hyperlipidemic mice stenosis. Currently, there is no non- invasive medical therapy for CAVD. Exposure to high aspect ratio nanomaterials, such as multi-walled September Cardiovascular health effects of oral and pulmonary exposure to carbon nanotubes (MWCNTs) may be 01, 2016 multi-walled carbon nanotubes in ApoE-deficient mice associated with increased risk of atherosclerosis, Aneurysm-osteoarthritis syndrome Defective Connective Tissue Remodeling in Smad3 Mice Leads to September characterized by unpredictable aortic Accelerated Aneurysmal Growth through Disturbed Downstream 01, 2016 aneurysm formation, is caused by TGF-β Signaling SMAD3 mutations. A major complication of haemophilia is September Visualization of haemophilic arthropathy in F8 −/− rats by haemophilic arthropathy (HA), a 01, 2016 ultrasonography and micro-computed tomography debilitating disorder with an incompletely defined pathobiology. Aging leads to a high prevalence of June 01, Resveratrol Decreases TXNIP mRNA and Protein Nuclear glucose intolerance and cardiovascular 2016 Expressions With an Arterial Function Improvement in Old Mice diseases, with oxidative stress playing a potential role. Deep vein thrombosis and common complications, including pulmonary February Assessment of Venous Thrombosis in Animal Models embolism and post-thrombotic syndrome, 01, 2016 represent a major source of morbidity and mo January Partial Portal Vein Arterialization Attenuates Acute Bile Duct Injury Hepatic infarcts or abscesses occur after 01, 2015 Induced by Hepatic Dearterialization in a Rat Model hepatic artery interruption. OBJECTIVE To understand the anatomy January Ascending Aortic Aneurysm in Angiotensin II-Infused Mice: and physiology of ascending aortic 01, 2015 Formation, Progression, and the Role of Focal Dissections. aneurysms in angiotensin II-infused ApoE(-/-) mice. Accelerated Blood Clearance Phenomenon Reduces the Passive January Peripheral arterial disease (PAD) is a Targeting of PEGylated Nanoparticles in Peripheral Arterial 01, 2015 leading global health concern. Disease Spinal cord injury (SCI) is a life- Fetal and Neonatal Stem Cells Early Intravenous Delivery of January threatening Human Brain Stromal Cells Modulates Systemic Inflammation and 01, 2015 conditionwithmultifacetedcomplications Leads to Vasoprotection in Traumatic Spinal Cord Injury andlimitedtreat- ment options. The precise flow characteristics that January Influence of shear stress magnitude and direction on promote different atherosclerotic plaque 01, 2015 atherosclerotic plaque composition types remain unclear. Background, Motivation and Objective January Comparison of Arterial Input Function Models for Small-Animal Bolus & burst (B&B) is a method for 01, 2015 Ultrasound Perfusion Imaging quantitative ultrasound perfusion analysis combining bolus tracking and burst The conversion of vascular smooth January Smooth muscle FGF/TGFbeta cross talk regulates atherosclerosis muscle cells (SMCs) from contractile to 01, 2015 progression proliferative phenotype is thought to play an important role in atherosclero Abstract As peripheral arterial disease Re-assessing the enhanced permeability and retention effect in January (PAD) results in muscle ischemia and peripheral arterial disease using radiolabeled long circulating 01, 2015 neovascularization, it has been claimed nanoparticles that nanoparticles can passively To determine whether Nordic walking improves cardiovascular function in September Influence of physical activity and gender on arterial function in middle-aged women and men, we 01, 2015 type 2 diabetes, normal and impaired glucose tolerance included 121 with normal glucose tolerance, 33 w The first clinical trial of tissue-engineered June 01, The innate immune system contributes to tissue-engineered vascular grafts (TEVGs) identified 2015 vascular graft performance stenosis as the primary cause of graft failure.

OBJECTIVE: Cardiovascular interventions induce damage to the April 02, Noninvasive Molecular Ultrasound Monitoring of Vessel Healing vessel wall making antithrombotic therapy 2015 After Intravascular Surgical Procedures in a Preclinical Setup. inevitable until complete endothelial recovery. Purpose To noninvasively assess vascular hemodynamics with April 01, Photoacoustic Imaging of Vascular Hemodynamics: Validation photoacoustic imaging (PAI) and blood 2015 with Blood Oxygenation Level–Dependent MR Imaging oxygenation level-dependent (BOLD) magnetic resonance January Prostaglandin E synthase is upregulated by Gas6 during cancer- Venous thromboembolism (VTE) is a 01, 2015 induced venous thrombosis. common complication of cancer. The pathophysiological mechanisms of January Axl modulates immune activation of smooth muscle cells in vein the immune activation of smooth muscle 01, 2015 graft remodeling. cells are not well understood. Aims In myocardial ischaemia, vascular January Rip2 modifies VEGF-induced signalling and vascular permeability endothelial growth factor (VEGF) induces 01, 2015 in myocardial ischaemia permeability by activating a signalling path- way that includes VEGF r Calcific aortic valve disease (CAVD) is January Multimodality and Molecular Imaging of Matrix Metalloproteinase the most common cause of aortic 01, 2015 Activation in Calcific Aortic Valve Disease stenosis. Acute reductions in mechanical wall strain precede the formation OBJECTIVE: Intimal hyperplasia (IH) November of intimal hyperplasia in a murine model of arterial occlusive continues to plague the durability of 01, 2014 disease vascular interventions. Risk factors for fibrocal- cific aortic valve May 01, Aortic valve sclerosis in mice deficient in endothelial nitric oxide disease (FCAVD) are associated with 2014 synthase systemic decreases in bioavailability of endothelium-derived nitric Intermittent claudication is a form of April 15, Exercise performance and peripheral vascular insufficiency exercise intolerance characterized by 2014 improve with AMPK activation in high-fat diet-fed mice muscle pain during walking in patients with peripheral artery disease (PA Increasing age involves a number of January detrimental changes in the cardiovascular Age-related vascular gene expression profiling in mice 01, 2014 system and particularly on the large arteries. The abdominal aortic aneurysm (AAA) is January Monitoring and staging abdominal aortic aneurysm disease with a silent and often deadly vascular 01, 2014 pulse wave imaging. disease caused by the localized weakening of the arterial wall. Gold nanorods (NRs) are attractive for in November Development and optimization of near-IR contrast agents for vivo imaging due to their high optical 01, 2013 immune cell tracking cross-sections and tunable absorbance.

BACKGROUND: The ability to image Rhodamine-Loaded Intercellular Adhesion Molecule-1-targeted November incipient atherosclerosis is based on the Microbubbles for Dual-Modality Imaging Under Controlled Shear 01, 2013 early events taking place at the Stresses endothelial level. Glucose-stimulated insulin secretion causes an insulin-dependent This study tested the hypothesis that July 15, nitric oxide-mediated vasodilation in the blood supply of the rat acute hyperglycemia reduces sciatic 2013 sciatic nerve nerve blood flow in Sprague-Dawley rats. Lymph node size is an important variable April 01, Enhanced Sonographic Imaging to Diagnose Lymph Node in ultrasound diagnosis of lymph node 2013 Metastasis: Importance of Blood Vessel Volume and Density metastasis. Most solid tumors are characterized by a March 28, Mitochondrial activation by inhibition of PDKII suppresses HIF1a metabolic shift from glucose oxidation to 2013 signaling and angiogenesis in cancer glycolysis, in part due to actively suppressed mitochondrial functi BACKGROUND: In atherosclerosis, local Molecular imaging of inflammation and platelet adhesion in January generation of reactive oxygen species advanced atherosclerosis effects of antioxidant therapy with 01, 2013 amplifies the inflammatory response and NADPH oxidase inhibition. contributes to plaque vulnerabilit This project compared quantifiable January High and low frequency subharmonic imaging of angiogenesis in measures of tumor vascularity obtained 01, 2013 a murine breast cancer model from contrast-enhanced high frequency (HF) and low frequency (LF) subharmoni Injection of Vessel-Derived Stem Cells Prevents Dilated Duchenne muscular dystrophy (DMD) is January Cardiomyopathy and Promotes Angiogenesis and Endogenous the most common form of muscular 01, 2013 Cardiac Stem Cell Proliferation in mdx/utrn-/- but Not Aged mdx dystrophy. Mouse Models for Duchenne Muscular Dystrophy OBJECTIVE: Activation of inflammatory December Inhibition of Notch1 signaling reduces abdominal aortic aneurysm pathways plays a critical role in the 01, 2012 in mice by attenuating macrophage-mediated inflammation. development of abdominal aortic aneurysms (AAA). Vascular disrupting agents (VDAs) are an November The Vascular Disrupting Agent STA-9584 Exhibits Potent emerging class of therapeutics targeting 01, 2012 Antitumor Activity by Selectively Targeting Microvasculature at the existing vascular network of solid Both the Center and Periphery of Tumors tumors.

We hypothesized that neuropeptide Y September (NPY) exerts vasoconstrictor properties in Y1R control of sciatic nerve blood flow in the Wistar Kyoto rat. 01, 2012 sciatic nerve blood supply by a Y1 receptor (Y1R) mechanism. OBJECTIVE: The underlying causes of August 01, Murine ultrasound imaging for circumferential strain analyses in abdominal aortic aneurysms (AAAs) 2012 the angiotensin II abdominal aortic aneurysm model remain obscure, although research tools such as the angiotensin II (Ang II) apol Enhanced angiogenic and cardiomyocyte differentiation capacity RATIONALE: Although bone marrow July 06, of epigenetically reprogrammed mouse and human endothelial endothelial progenitor cell (EPC)-based 2012 progenitor cells augments their efficacy for ischemic myocardial therapies improve the symptoms in repair. patients with ischemic heart disease, their Novel Single-Chain Antibody-Targeted Microbubbles for BACKGROUND: Molecular imaging is a Molecular Ultrasound Imaging of Thrombosis: Validation of a June 26, fast emerging technology allowing Unique Noninvasive Method for Rapid and Sensitive Detection of 2012 noninvasive detection of vascular Thrombi and Monitoring of Success or Failure of Thrombolysis in pathologies. Mice Endothelial expression of hypoxia-inducible factor 1 protects the Chronic systemic hypertension causes April 03, murine heart and aorta from pressure overload by suppression of cardiac pressure overload leading to 2012 TGF-β signaling. increased myocardial O(2) consumption. Metronomic chemotherapy refers to the Low-dose metronomic oral dosing of a prodrug of gemcitabine March 01, close, regular administration of (LY2334737) causes antitumor effects in the absence of inhibition 2012 conventional chemotherapy drugs at of systemic vasculogenesis. relatively low, minimally toxic doses, with BACKGROUND: The proprotein convertase subtilisin/kexin type 9 February Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type (PCSK9) promotes independently of its 21, 2012 9 Reduces Atherosclerosis in Mice enzymatic activity the degradation of the low-dens INTRODUCTION: As yet, murine aortic February Non- invasive in vivo analysis of a murine aortic graft using high grafts have merely been monitored 01, 2012 resolution ultrasound microimaging. histopathologically. Intravascular photoacoustic (IVPA) January Intravascular photoacoustic imaging of lipid in atherosclerotic imaging can characterize atherosclerotic 01, 2011 plaques in the presence of luminal blood plaque composition on the basis of the optical absorption contrast between PURPOSE: Given that carotid vasa Molecular Imaging of Vasa Vasorum Neovascularization via December vasorum neovascularization is associated DEspR-targeted Contrast-enhanced Ultrasound Micro-imaging in 23, 2011 with increased risk for stroke and cardiac Transgenic Atherosclerosis Rat Model events, the present in vivo study The ability to form anastomoses with the Bioengineered human vascular networks transplanted into December host circulation is essential for vascular secondary mice reconnect with the host vasculature and re- 15, 2011 networks incorporated within cell-seeded establish perfusion bioengineered tissues. Imaging guided trials of the angiogenesis inhibitor sunitinib in Preclinical trials in mice represent a December mouse models predict efficacy in pancreatic neuroendocrine but critical step in the evaluation of 06, 2011 not ductal carcinoma. experimental therapeutics. The primary graft-related complication December A critical role for macrophages in neovessel formation and the during the first clinical trial evaluating the 01, 2011 development of stenosis in tissue-engineered vascular grafts use of tissue-engineered vascular grafts (TEVGs) was stenosis. Acoustic liposomes (AL) have their November Volumetric and Angiogenic Evaluation of Antitumor Effects with inherent echogenicity and can add 15, 2011 Acoustic Liposome and High-Frequency Ultrasound functionality in serving as drug carriers with tissue specificity. The suprachiasmatic nucleus of the brain October Tissue-intrinsic dysfunction of circadian clock confers transplant is the circadian center, relaying rhythmic 11, 2011 arteriosclerosis environmental and behavioral information to peripheral tissues to The study of hemodynamic alterations October Regional and systemic hemodynamic responses following the following the creation of an arteriovenous 01, 2011 creation of a murine arteriovenous fistula fistula (AVF) is relevant to vascular adaptive responses and hemodialy We sought to characterize temporal gene September Transcriptional profiling and network analysis of the murine expression changes in the murine 08, 2011 angiotensin II-induced abdominal aortic aneurysm. angiotensin II (ANG II)-ApoE-/- model of abdominal aortic aneurysm (AAA). OBJECTIVE: Velocity vector imaging can July 01, Longitudinal common carotid artery wall motion is associated with be used to assess longitudinal common 2011 plaque burden in man and mouse carotid artery (CCA) wall movement (tLoD) in man. Calcific aortic valve stenosis (CAVS) is a May 27, Calcific aortic valve stenosis: methods, models, and mechanisms. major health problem facing aging 2011 societies.

PURPOSE: Hypoxia-inducible factor 1 March 01, HIF-1-dependent stromal adaptation to ischemia mediates in vivo (HIF-1) promotes cancer cell survival and 2011 tumor radiation resistance. tumor progression. OBJECTIVE: To quantitatively compare February Influences of aortic motion and curvature on vessel expansion in aortic curvature and motion with resulting 01, 2011 murine experimental aneurysms. aneurysm location, direction of expansion, and pathophysiological feat Over the past decade, non-invasive January preclinical imaging has emerged as an Micro-ultrasound for preclinical imaging 01, 2010 important tool to facilitate biomedical discovery. We studied prospectively whether atherosclerotic progression in January Micro-Ultrasonographic Imaging of Atherosclerotic Progression apolipoprotein-E knock- out mice could 01, 2010 be noninvasively and accurately measured by use INTRODUCTION: Chemotherapy may January In vivo bioimaging as a novel strategy to detect doxorubicin- induce deleterious effects in normal 01, 2010 induced damage to gonadal blood vessels. tissues, leading to organ damage. Considerable evidence supports that the November A Critical Function of Th17 Proinflammatory Cells in the CD4(+) T cell-mediated immune response 15, 2010 Development of Atherosclerotic Plaque in Mice contributes to the development of atherosclerotic plaque. OBJECTIVE: Hemodynamics plays a June 01, Aortic regurgitation dramatically alters the distribution of critical role in atherogenesis, but the 2010 atherosclerotic lesions and enhances atherogenesis in mice. association between flow pattern and preferential localization of lesion is no OBJECTIVE: Torcetrapib, a prototype May 01, Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein (CETP) 2010 cholesteryl ester transfer protein inhibition. inhibitor with potential for decreasing atherosclerotic disease, increas Purpose: Materials and Methods: To Antiangiogenic Cancer Therapy : Monitoring with Molecular US develop and test human kinase insert January and a Clinically Translatable Contrast Purpose : Methods : domain receptor (KDR)-targeted 01, 2009 Results : microbubbles (MBs) (MB KDR ) for imaging KDR at Atherosclerosis is closely associated with October Partial carotid ligation is a model of acutely induced disturbed flow, disturbed flow characterized by low and 01, 2009 leading to rapid endothelial dysfunction and atherosclerosis. oscillatory shear stress, but studies directly linking disturbed fl Purpose: To develop and validate a dual- September Dual-targeted Contrast Agent for US Assessment of Tumor targeted ultrasound imaging agent that 01, 2008 Angiogenesis in Vivo attaches to both vascular endothelial growth factor receptor-2 (VEGFR2) This study was aimed to test the March 01, Micro-ultrasound imaging assessment of carotid plaque hypothesis that noninvasive assessment 2008 characteristics in apolipoprotein-E knockout mice. of carotid plaques can be achieved by high-resolution micro-ultrasound imaging In humans, endothelial vasodilator February In vivo measurement of flow-mediated vasodilation in living rats function serves as a surrogate marker for 01, 2008 using high-resolution ultrasound. cardiovascular health and is measured as changes in conduit artery diamet OBJECTIVES: The purpose of this study January High-Resolution Ultrasound Perfusion Imaging of Therapeutic was to test the feasibility of contrast pulse 01, 2008 Angiogenesis sequence (CPS) ultrasound imaging for high-resolution perfusion im Purpose: Materials and Methods: Results: Targeted Microbubbles for Imaging Tumor Angiogenesis: January Conclusion: To evaluate in vivo whole- assessment of whole body biodistribution with dynamic micro-PET 01, 2008 body biodistribution of micro- bubbles in mice. (MBs) targeted to tumor angiogen "Mitocans" from the vitamin E group of Vitamin E analogues inhibit angiogenesis by selective induction of December selective anticancer drugs, alpha- apoptosis in proliferating endothelial cells: the role of oxidative 15, 2007 tocopheryl succinate (alpha-TOS) and its stress. ether analogue alpha-TEA, triggered Blockade of vascular endothelial growth Detecting vascular changes in tumour xenografts using micro- August 01, factor (VEGF) binding to its receptors on ultrasound and micro-ct following treatment with VEGFR-2 2007 endothelial cells has been shown blocking antibodies. preclinically to induce tumour grow There are increasing needs to develop February Non-invasive real-time imaging of atherosclerosis in mice using imaging techniques to study in vivo 01, 2007 ultrasound biomicroscopy. vascular morphology and function in various mouse models of atherosclerosis. The imaging of plaque composition January Ex vivo Characterization of Atherosclerosis using Intravascular represents one of the important steps in 01, 2007 Photoacoustic Imaging. the interventional management of atherosclerosis. The aim of our study was to investigate Molecular Imaging of Vascular Endothelial Growth Factor January the use of targeted con- trast-enhanced Receptor 2 Expression using targeted contrast enhanced High 01, 2007 high-frequency ultrasonography for frequency ultrasonography molecular imaging of vascular endot In human pregnancy, abnormal placental Developmental changes in hemodynamics of uterine artery, utero- May 26, hemodynamics likely contribute to the and umbilicoplacental, and vitelline circulations in mouse 2006 etiology of early-onset preeclampsia and throughout gestation fetal intrauterine growth restri PURPOSE: Ultrasound biomicroscopy July 01, Quantitation of hemodynamic function during developmental (UBM) utilizes frequencies higher than 2005 vascular regression in the mouse eye. conventional diagnostic ultrasound and can noninvasively provide anatomic and