Ayahuasca Analogues and Plant-Based Tryptamines
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Multiple Polyploidy Events in the Early Radiation of Nodulating And
Multiple Polyploidy Events in the Early Radiation of Nodulating and Nonnodulating Legumes Steven B. Cannon,*,y,1 Michael R. McKain,y,2,3 Alex Harkess,y,2 Matthew N. Nelson,4,5 Sudhansu Dash,6 Michael K. Deyholos,7 Yanhui Peng,8 Blake Joyce,8 Charles N. Stewart Jr,8 Megan Rolf,3 Toni Kutchan,3 Xuemei Tan,9 Cui Chen,9 Yong Zhang,9 Eric Carpenter,7 Gane Ka-Shu Wong,7,9,10 Jeff J. Doyle,11 and Jim Leebens-Mack2 1USDA-Agricultural Research Service, Corn Insects and Crop Genetics Research Unit, Ames, IA 2Department of Plant Biology, University of Georgia 3Donald Danforth Plant Sciences Center, St Louis, MO 4The UWA Institute of Agriculture, The University of Western Australia, Crawley, WA, Australia 5The School of Plant Biology, The University of Western Australia, Crawley, WA, Australia 6Virtual Reality Application Center, Iowa State University 7Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada 8Department of Plant Sciences, The University of Tennessee Downloaded from 9BGI-Shenzhen, Bei Shan Industrial Zone, Shenzhen, China 10Department of Medicine, University of Alberta, Edmonton, AB, Canada 11L. H. Bailey Hortorium, Department of Plant Biology, Cornell University yThese authors contributed equally to this work. *Corresponding author: E-mail: [email protected]. http://mbe.oxfordjournals.org/ Associate editor:BrandonGaut Abstract Unresolved questions about evolution of the large and diverselegumefamilyincludethetiming of polyploidy (whole- genome duplication; WGDs) relative to the origin of the major lineages within the Fabaceae and to the origin of symbiotic nitrogen fixation. Previous work has established that a WGD affects most lineages in the Papilionoideae and occurred sometime after the divergence of the papilionoid and mimosoid clades, but the exact timing has been unknown. -
Psychoactive Plants Used in Designer Drugs As a Threat to Public Health
From Botanical to Medical Research Vol. 61 No. 2 2015 DOI: 10.1515/hepo-2015-0017 REVIEW PAPER Psychoactive plants used in designer drugs as a threat to public health AGNIESZKA RONDZISTy1, KAROLINA DZIEKAN2*, ALEKSANDRA KOWALSKA2 1Department of Humanities in Medicine Pomeranian Medical University Chłapowskiego 11 70-103 Szczecin, Poland 2Department of Stem Cells and Regenerative Medicine Institute of Natural Fibers and Medicinal Plants Kolejowa 2 62-064 Plewiska, Poland *corresponding author: e-mail: [email protected] Summary Based on epidemiologic surveys conducted in 2007–2013, an increase in the consumption of psychoactive substances has been observed. This growth is noticeable in Europe and in Poland. With the ‘designer drugs’ launch on the market, which ingredients were not placed on the list of controlled substances in the Misuse of Drugs Act, a rise in the number and diversity of psychoactive agents and mixtures was noticed, used to achieve a different state of mind. Thus, the threat to the health and lives of people who use them has grown. In this paper, the authors describe the phenomenon of the use of plant psychoactive sub- stances, paying attention to young people who experiment with new narcotics. This article also discusses the mode of action and side effects of plant materials proscribed under the Misuse of Drugs Act in Poland. key words: designer drugs, plant materials, drugs, adolescents INTRODUCTION Anthropological studies concerning preliterate societies have shown that psy- choactive substances have been used for ages. On the individual level, they help to Herba Pol 2015; 61(2): 73-86 A. Rondzisty, K. -
Armortech ® THREESOME ® Label
2,4-D • MECOPROP-p • DICAMBA Threesome® Herbicide Selective broadleaf weed control for turfgrass including use on sod farms. To control clover, dandelion, henbit, plantains, wild onion, and many other broadleaf weeds. Also for highways, rights-of-way and other similar non-crop areas as listed on this label. Contains 2,4-D, mecoprop-p, and dicamba. ACTIVE INGREDIENTS KEEP OUT OF REACH OF CHILDREN Dimethylamine Salt of 2,4-Dichlorophenoxyacetic Acid* .......30.56% Dimethylamine Salt of (+)-R-2-(2-Methyl-4-Chlorophenoxy) DANGER – PELIGRO propionic Acid**‡ .......................................................................8.17% Si usted no entiende la etiqueta, busque a alguien para que se la Dimethylamine Salt of Dicamba (3,6-Dichloro-o-anisic Acid)*** 2.77% explique a usted en detalle. (If you do not understand the label, find someone to explain it to you OTHER INGREDIENTS: ......................................................................58.5% in detail.) TOTAL: ....................................................................................100.00% Isomer Specific Method, Equivalent to: *2,4-Dichlorophenoxyacetic Acid ................................... 25.38%, 2.38 lbs/gal PRECAUTIONARY STATEMENTS **(+)-R-2-(2-Methyl-4-Chlorophenoxy)propionic Acid.... 6.75%, 0.63 lbs/gal HAZARDS TO HUMANS AND DOMESTIC ANIMALS ***3,6-Dichloro-o-anisic Acid .......................................... 2.30%, 0.22 lbs/gal Corrosive. Causes irreversible eye damage. Do not get in eyes, or on skin or clothing. ‡CONTAINS THE SINGLE ISOMER FORM OF MECOPROP-p Harmful if swallowed. FIRST AID IF • Call a poison control center or doctor immediately for treatment advice. HOT LINE NUMBER SWALLOWED: • Have person sip a glass of water if able to swallow. Have the product container or label with you when calling a poison control • Do not induce vomiting unless told to do so by the poison control center or doctor. -
Weed Discrimination Using Ultrasonic Sensors
INSIGHTS DOI: 10.1111/j.1365-3180.2011.00876.x Weed discrimination using ultrasonic sensors D ANDU´JAR*, A ESCOLA` , J DORADO* & C FERNA´NDEZ-QUINTANILLA* *Instituto de Ciencias Agrarias, CSIC, Madrid, Spain, and Universitat de Lleida, Lleida, Spain Received 11 March 2011 Revised version accepted 7 June 2011 Subject Editor: Peter Lutman, UK sis revealed that the ultrasonic data could separate three Summary groups of assemblages: pure stands of broad-leaved A new approach is described for automatic discrimina- weeds (lower height), pure stands of grasses (higher tion between grasses and broad-leaved weeds, based on height) and mixed stands of broad-leaved and grass their heights. An ultrasonic sensor was mounted on the weeds (medium height). Dynamic measurements con- front of a tractor, pointing vertically down in the inter- firmed the potential of this system to detect weed row area, with a control system georeferencing and infestations. This technique offers significant promise for registering the echoes reflected by the ground or by the the development of real-time spatially selective weed various leaf layers. Static measurements were taken at control techniques, either as the sole weed detection locations with different densities of grasses (Sorghum system or in combination with other detection tools. halepense) and broad-leaved weeds (Xanthium strumar- Keywords: weed species discrimination, site-specific ium and Datura spp.). The sensor readings permitted the weed management, wide-row crops, ultrasound detec- discrimination of pure stands of grasses (up to 81% tion, patch, sonar. success) and pure stands of broad-leaved weeds (up to 99% success). Moreover, canonical discriminant analy- ANDU´JAR D, ESCOLA` A, DORADO J&FERNA´NDEZ-QUINTANILLA C (2011). -
Erowid Extracts — Number 13 / November 2007 Erowid Extracts Table of Contents Number 13, November 2007
Erowid® Extracts D OCUMENTING THE C OMPLEX R ELATIONSHIP B ETWEEN H UMANS AN D P SYCHOACTIVES November 2007 Number 13 “The problem to be faced is: how to combine loyalty to one’s own tradition with reverence for different traditions.” — Abraham J. Heschel The Absinthe Enigma • Wormwood and Thujone • P. viridis vs. M. tenuiflora Varieties of Nicotine Experience • Khat Legal Challenges LETTERS & FEEDBACK Hi there Erowid staff, First of all, thank you for such Awesome website! A more thoughtfully a wonderful site. I’m not a serious compiled compendium of information I’m just writing to say how much I recreational user, but having some on the topic of psychoactives does appreciate your website. My father chronic pain issues, I tend to experiment not exist—at least not for the public showed it to me several years ago a little to find ways to alleviate the at large. Bravo. and it’s been fun to watch it grow pain (aside from standard Rx’s from in quality and content over the — ANOnymOus doctors). […] years. My dad adjunctly teaches a Letter to Erowid psychopharmacology class in town and Keep up the good work. Although always lists Erowid on his syllabus of some might look at Erowid negatively, recommended readings. I’m a college I look at it positively, in the sense that After looking up information on the student and am surprised, once I I’m smart enough to research things antitussive properties of DXM, how start talking to other kids, how many before I try them, and hopefully keep shocked I was to find your website, of them know about the information myself from an early demise. -
JONATHAN OTT SPEAKS… PART TWO Interviewed by Will Beifuss and Jon Hanna at the 1998 BPC Salvia Divinorum Conference
VOLUME VIII, NUMBER 2 SUMMER SOLSTICE 1999 JONATHAN OTT SPEAKS… PART TWO Interviewed by Will Beifuss and Jon Hanna at the 1998 BPC Salvia divinorum Conference Jon: Living in México, what do you think that the interest in at home and make tea.” But if I do that in the U.S. I know for entheogens is there, given in a sort of comparative percent- a fact that there are going to be at least a dozen people there age? that have done it more than I have, and perhaps can teach me a thing or two if I can just connect with them afterwards Jonathan: Of course we have, at best, only soft figures in any and share information. And so the U.S. is a real leader there, case. But I would say that it’s less than it is in the U.S., in and I would say in México it’s a great deal less. But on the terms of the kind of interest that we know about—basement other hand, there’s this schizophrenic thing; on the one hand shaman. In the U.S. there’s a great deal of sophistication in there’s racism against Indians and there’s this whole socio- the so-called amateur sector. And that doesn’t exist any- economic one-upmanship, but on the other hand, all of where else, not even in Europe. In Europe, the only people México’s glory lies in the pre-Colombian past, and it’s been that are at that level of sophistication are in the business as all downhill—and very steeply—politically and economi- shamanic-plant dealers, and they’re very few. -
Mimosa Tenuiflora (Willd.) Poiret Under Water Deficit and Rewatering
Journal of Agricultural Studies ISSN 2166-0379 2019, Vol. 7, No. 4 Gas Exchange of Mimosa tenuiflora (Willd.) Poiret Under Water Deficit and Rewatering Francisco Jose Basilio Alves, Antonio Lucineudo Oliveira Freire (Corresponding Author) Dept. of Forest Engineering, Federal University of Campina Grande, Brazil Received: Aug. 26, 2019 Accepted: Oct. 29, 2019 Published: Oct. 30, 2019 doi:10.5296/jas.v7i4.15338 URL: https://doi.org/10.5296/jas.v7i4.15338 Abstract This research aimed to evaluate the physiological responses of Mimosa tenuiflora plants submitted to variable water availability conditions during the nursery stage. Twelve-month-old plants kept in plastic pots containing 5 kg of the substrate composed of the subsoil soil mixture and bovine manure (2:1) were submitted to two treatments: irrigated (control) and water stress, which was imposed through the suspension of irrigation, rewatering after seven days of stress. The relative water content (RWC) and stomatal parameters were evaluated. The M. tenuiflora plants responded quickly to the irrigation suspension, promoting the closure of the stomata, occurring reduction in stomatal conductance, transpiration rate and photosynthesis. The instantaneous efficiency in water use of plants under water deficit remained high only until the middle of the period when irrigation was suspended, and then declined until the last day of the water deficit. After rehydration, the plants showed recovery in all evaluated parameters, indicating that the level of stress imposed did not cause irreversible damages in the cells and tissues. Keywords: water stress, drought tolerance, water relations 1. Introduction Mimosa tenuiflora (Willd.) Poiret.), popularly named ‘jurema-preta’, is one of the most commonly woody species in the Brazilian semiarid, belonging to the Mimosaceae family. -
The WITCH DOCTOR
The WITCH DOCTOR Alignment: Any Abilities: Wisdom and Charisma are the primaries for a Witch Doctor Hit Dice: d6 Races: Aboriginal Humans are the only known race to become Witch Doctors Class Skills Concentration (Con) Intimidate (Cha) Knowledge Religion (Int) Perform (Cha) Craft (Int) Knowledge Arcana (Int) Handle Animal (Cha) Spellcraft (Int) Diplomacy (Cha) Knowledge Nature (Int) Listen (Wis) Spot (Wis) Heal (Wis) Knowledge Planar (Int) Use Magical Device (Cha) Survival (Wis) Skill Points at 1st Level: (4 + Int Modifier) x 4 Skill Points at Each Additional Level: 4 + Int Modifer Class Features Weapon and Armor Proficiency Witch Doctors are proficient with all simple weapons (including the blowgun in the Dungeon Master's Guide). They are also proficient with Medicine Mojos. Witch Doctors are not proficient with any type of armor or shield. Armor of any type interferes with a Witch Doctor’s gestures, which can cause his Rituals and Spells to fail. Spells A Witch Doctor may only choose spells from the Witch Doctor spell list, absolutely no exception can be made in this regard. His spells per day of each level are equal to half of his spells known, rounded down. A Witch Doctor must meditate for one hour everyday and speak with the spirits to retain the knowledge of his spells. Spell do not need to be memorized, every time a spell is cast the Witch Doctor may choose among his list of known spells. Table 1-1: Witch Doctor Spells Known Spells Known Level 1st 2nd 3rd 4th 5th 6th 1st 2 - - - - - 2nd 3 - - - - - 3rd 4 - - - - - 4th 5 2 - - - - 5th 6 3 - - - - 6th 6 4 - - - - 7th 6 5 2 - - - 8th 6 6 3 - - - 9th 6 6 4 - - - 10th 6 6 5 2 - - 11th 6 6 6 3 - - 12th 6 6 6 4 - - 13th 6 6 6 5 2 - 14th 6 6 6 6 3 - 15th 6 6 6 6 4 - 16th 6 6 6 6 5 2 17th 6 6 6 6 6 3 18th 6 6 6 6 6 4 19th 6 6 6 6 6 5 20th 6 6 6 6 6 6 Spirits and Superstitions All of the Witch Doctor's spells are granted by the spirits, some good some bad. -
(DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact
pharmaceuticals Review Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact Andreia Machado Brito-da-Costa 1 , Diana Dias-da-Silva 1,2,* , Nelson G. M. Gomes 1,3 , Ricardo Jorge Dinis-Oliveira 1,2,4,* and Áurea Madureira-Carvalho 1,3 1 Department of Sciences, IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies, University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal; [email protected] (A.M.B.-d.-C.); ngomes@ff.up.pt (N.G.M.G.); [email protected] (Á.M.-C.) 2 UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal 3 LAQV-REQUIMTE, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal 4 Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal * Correspondence: [email protected] (D.D.-d.-S.); [email protected] (R.J.D.-O.); Tel.: +351-224-157-216 (R.J.D.-O.) Received: 21 September 2020; Accepted: 20 October 2020; Published: 23 October 2020 Abstract: Ayahuasca is a hallucinogenic botanical beverage originally used by indigenous Amazonian tribes in religious ceremonies and therapeutic practices. While ethnobotanical surveys still indicate its spiritual and medicinal uses, consumption of ayahuasca has been progressively related with a recreational purpose, particularly in Western societies. The ayahuasca aqueous concoction is typically prepared from the leaves of the N,N-dimethyltryptamine (DMT)-containing Psychotria viridis, and the stem and bark of Banisteriopsis caapi, the plant source of harmala alkaloids. -
Ayahuasca Characterization, Metabolism in Humans, And
Louisiana State University LSU Digital Commons LSU Doctoral Dissertations Graduate School 2012 Ayahuasca characterization, metabolism in humans, and relevance to endogenous N,N- dimethyltryptamines Ethan Hamilton McIlhenny Louisiana State University and Agricultural and Mechanical College, [email protected] Follow this and additional works at: https://digitalcommons.lsu.edu/gradschool_dissertations Part of the Medicine and Health Sciences Commons Recommended Citation McIlhenny, Ethan Hamilton, "Ayahuasca characterization, metabolism in humans, and relevance to endogenous N,N- dimethyltryptamines" (2012). LSU Doctoral Dissertations. 2049. https://digitalcommons.lsu.edu/gradschool_dissertations/2049 This Dissertation is brought to you for free and open access by the Graduate School at LSU Digital Commons. It has been accepted for inclusion in LSU Doctoral Dissertations by an authorized graduate school editor of LSU Digital Commons. For more information, please [email protected]. AYAHUASCA CHARACTERIZATION, METABOLISM IN HUMANS, AND RELEVANCE TO ENDOGENOUS N,N-DIMETHYLTRYPTAMINES A Dissertation Submitted to the Graduate Faculty of the Louisiana State University and School of Veterinary Medicine in partial fulfillment of the requirements for the degree of Doctor of Philosophy in The Interdepartmental Program in Veterinary Medical Sciences through the Department of Comparative Biomedical Sciences by Ethan Hamilton McIlhenny B.A., Skidmore College, 2006 M.S., Tulane University, 2008 August 2012 Acknowledgments Infinite thanks, appreciation, and gratitude to my mother Bonnie, father Chaffe, brother Matthew, grandmothers Virginia and Beverly, and to all my extended family, friends, and loved ones. Without your support and the visionary guidance of my friend and advisor Dr. Steven Barker, none of this work would have been possible. Special thanks to Dr. -
Chemical Composition of Traditional and Analog Ayahuasca
Journal of Psychoactive Drugs ISSN: (Print) (Online) Journal homepage: https://www.tandfonline.com/loi/ujpd20 Chemical Composition of Traditional and Analog Ayahuasca Helle Kaasik , Rita C. Z. Souza , Flávia S. Zandonadi , Luís Fernando Tófoli & Alessandra Sussulini To cite this article: Helle Kaasik , Rita C. Z. Souza , Flávia S. Zandonadi , Luís Fernando Tófoli & Alessandra Sussulini (2020): Chemical Composition of Traditional and Analog Ayahuasca, Journal of Psychoactive Drugs, DOI: 10.1080/02791072.2020.1815911 To link to this article: https://doi.org/10.1080/02791072.2020.1815911 View supplementary material Published online: 08 Sep 2020. Submit your article to this journal View related articles View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=ujpd20 JOURNAL OF PSYCHOACTIVE DRUGS https://doi.org/10.1080/02791072.2020.1815911 Chemical Composition of Traditional and Analog Ayahuasca Helle Kaasik a, Rita C. Z. Souzab, Flávia S. Zandonadib, Luís Fernando Tófoli c, and Alessandra Sussulinib aSchool of Theology and Religious Studies; and Institute of Physics, University of Tartu, Tartu, Estonia; bLaboratory of Bioanalytics and Integrated Omics (LaBIOmics), Institute of Chemistry, University of Campinas (UNICAMP), Campinas, SP, Brazil; cInterdisciplinary Cooperation for Ayahuasca Research and Outreach (ICARO), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil ABSTRACT ARTICLE HISTORY Traditional ayahuasca can be defined as a brew made from Amazonian vine Banisteriopsis caapi and Received 17 April 2020 Amazonian admixture plants. Ayahuasca is used by indigenous groups in Amazonia, as a sacrament Accepted 6 July 2020 in syncretic Brazilian religions, and in healing and spiritual ceremonies internationally. -
Chemistry, Pharmacology and Medicinal Properties of Peganum Harmala L
African Journal of Pharmacy and Pharmacology Vol. 6(22), pp. 1573-1580, 15 June, 2012 Available online at http://www.academicjournals.org/AJPP DOI: 10.5897/AJPP11.876 ISSN 1996-0816 ©2012 Academic Journals Review Chemistry, pharmacology and medicinal properties of Peganum harmala L. Jinous Asgarpanah and Fereshteh Ramezanloo Department of Pharmacognosy, Pharmaceutical Sciences Branch, Islamic Azad University (IAU), Tehran, Iran. Accepted 16 March, 2012 Peganum harmala L. is known as Syrian rue, Wild rue and Harmal. P. harmala extracts are considered important for drug development, because they are reported to have numerous pharmacological activities in the Middle East, especially in Iran and Egypt. For a long time P. harmala has been used in traditional medicines for the relief of pain and as an antiseptic agent. P. harmala also have antibacterial, antifungal, antiviral, antioxidant, antidiabetic, antitumor, antileishmanial, insecticidal and cytotoxic activities and hepatoprotective and antinociceptive effects. Harmaline, harmine, harmalol, harman, quinazoline derivatives, vasicine, vasicinone, anthroquinons and fixed oils are reported from seeds and roots of this plant. This plant is used as a medicine in Turkey, Syria, Iran, Pakistan, India, Egypt and Spain. This article presents comprehensive analyzed information on the botanical, chemical and pharmacological aspects of P. harmala. Key words: Peganum harmala, Zygophyllaceae, phytochemical, pharmacological properties. INTRODUCTION Peganum harmala commonly known as Syrian rue and many-branched stems may have a spread of four feet or Wild rue is a flowering plant and is widely distributed in more, the plant is rarely over two feet tall and generally the Central Asia, North Africa and Middle East. It has also appears round and bushy in habit.