DOCSLIB.ORG

Rxfiles Acne Chart.Pdf

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Rxfiles Acne Chart.Pdf ACNE Pharmacotherapy Comparison Chart Prepared by Margaret Jin, BSP, PharmD Candidate , L. Regier, B. Jensen - © www.RxFiles.ca Feb 09 3,4,5,6,7,8,9 Basic Care Suggested Step-wise Approach for Initial Therapy {Step-down in treatment intensity for maintenance following remission} D/C acnegenic moisturizers/substances; Use oil free makeup Isotretinoin Accutane, Clarus {Avoid topicals as ↑ drying effect & not tolerated} D/C manual lesions manipulation Avoid stress, astringents, scrubs Systemic antibiotics◊ ± Topicals {Resistance concerns: systemic ABX “pulse therapy” for more severe/inflammatory acne} Shaving: shave area lightly, only once & follow grain of hair growth Women: Oral Contraceptives (COCs)◊ or Diane 35◊ {Spironolactone◊ may be an alternative}; ± Topicals Wash face: preferably once daily & no more than BID with… If papulopustular (inflammatory) +/- comedonal: Add topical ABX to BP 10(may need lower BP strength to ↓ dryness); ± retinoid mild soap (e.g., Glycerin Bar, Petrophyllic, Pears, Aveeno, Dove & e.g. combo topical products (Benzamycin, Clindoxyl / BenzaClin) ± retinoid* OR Stievamycin. To maintain, may step down to retinoid. Olay) and water or soapless cleanser (e.g., Cetaphil, Spectro Jel) If comedonal (white-blackheads): Start topical retinoid {tretinoin 0.025-0.05% has cost advantage; adapalene less irritating}; may add BP. Avoid Soaps: such as Dial, Irish Spring, Ivory, & Zest that are 1) General measures (discontinue drying agents); 2) Initiation of Benzoyl Peroxide (BP) 2.5% or 5% H O-based gel e.g. Panoxyl Aquagel or 4% Solugel; or lotion more irritating, & associated with erythema, dryness, & itching 1 2 {if starting at 2.5%, consider increase to 5% H 0-based BP; acetone- or alcohol-based gel option if oily skin.} Patient education important!!! Moisturizers – in dry seasons (e.g. Complex-15 Moisturizing Lotion) 2 Sunlight: evidence lacking 2; may be helpful for some; however, Severity MILD MODERATE SEVERE long-term exposure ↑ risk of skin cancer. Description 11 < 20 comedones (whitehead/blackhead), or 15-50 papules & pustules with comedone; cysts are Primarily nodules & cysts; also present are comedones, Diet: chocolate=MYTH; individualize diet recommendations <15 inflammatory papules, or a lesion count <30 rare; Total lesion count may range from 30-125 papules & pustules or total lesion count of > 125. Scarring. GENERAL APPROACH for topical therapies: Oily skin Æ Use solution or gel; Dry skin Æ Use cream or lotions. Potency of a given drug in various vehicles: Solution > gel > cream / lotion. Apply to affected areas, not just lesions!!! Context: affects 85% of those age 12-24; duration varies ~4+ yrs. Concerns include: scarring, pain, self esteem, social life, suicide. Contributing factors: hormonal, mechanical, contact, environmental, emotions, drugs. Family hx predictive of acne severity/duration. 12,13,14 Acne - TOPICALS www.RxFiles.ca Generic/TRADE g=generic avail. Side effects (SE)/ Response √ = therapeutic use / := Disadvantage / Comments / USUAL DOSE $ per Contraindications CI Time Drug Interactions DI / Monitor M pkg -Strength/forms, Pregnancy Category 15 Allow at least 8 wks! (≤ 5% OTC) 50% st Benzoyl Peroxide = BP Common: contact dermatitis , 8-12 weeks √1 line medication for mild-moderate acne vulgaris as monotherapy; low cost Apply to entire OTC: W χ 8% 20% 10-15 H2O-based: Solugel 4%, 8% gel; Benzac^ dryness & peeling appear after a for noted √In combination with other agents for mod-severe acne; helps prevent ABX resistance! affected area W W χ Wχ 14% 1% AC or W 5% , 10% gel; Desquam X 10% few days; erythema ; burning ; & 2% improvement; √Benzac AC gel for sensitive/dry skin & Benzac W (Water) for oily/normal skin. QHS or BID W χ gel; Panoxyl Aquagel 2.5%, 5% gel pruritus ; may bleach hair/clothes; (but covered on some drug plans) : BP >5% no more efficacious than 2.5-5% & more irritation Rx: χ⊗ odor on clothing & bed sheets. 2-4 weeks: 2.5% or 5%; Proactiv soln 2.5% (System: cleanser, toner, lotion, $$$) : Washes & Soaps least effective Æ little residual contact time 15-25 clinical Alcohol-based: Benzagel 5%W χ, 10% gel; {Temporary reduction in application may help.} H20 based C worsening DI: ↑ skin irritation or drying effect – concomitant topical medication, medicated 18bar Panoxyl 5%W χ, 10%W, 15%W, 20%W gel Irritation: ↑ conc. = ↑ irritation generally better may occur abrasive soaps & cleansers, soaps & cosmetics with strong drying effect; products W χ H2O-based < alcohol=acetone-based tolerated Acetone-based: Acetoxyl 2.5, 5, 10% gel before with high concentrations of alcohol, astringents, spices or lime; isotretinoin Lotion: Oxy 5W χ 2.5%; Benoxyl 5%W χ, 10%W; Serious: Allergic reactions & contact {if 2.5% ineffective, 1-2% improvement BP’s oxidizing action degrades antibiotics or retinoids: space admin times! W sensitization dermatitis Benzagel 5 . Select list above - see then ↑to 5%.} {Or use premixed combination products such as Clindoxyl, BenzaClin, Benzamycin} Antibacterial, Keratolytic Keratolytic Antibacterial, references for a more complete list To reduce irritation initially apply q2-3days then ↑ frequency as tolerated or OTC: 2.5, 4, & 5% W χ W W χ Wχ W χ W χ Rx: 8, 10, 15, 20% Less Useful: Soap: Panoxyl 5% , 10% ; Wash: Benzac W 5% , 10%; Benzagel 5% ; Desquam X 5% , 10% ; Panoxyl apply for 2 hrs for 4 nights, 4hrs for 4 nights, & then leave on all night if tolerated. st TRETINOIN = TRE Common: erythema, dryness, burning, ~12 weeks for √1 line medication for mild-moderate comedonal (blackheads/whiteheads) acne QHS TRE: C 0.025-0.05% 0.1% 25g Retin-A 0.01% crm, 0.025% crm, 0.05% crm, 0.1% crm, 0.01% gel, photosensitization (less with adapalene) max response; √Tretinoin has cost advantage; Adapalene has less irritation advantage Apply 30-45 min 16 ; 20g 0.025% gel Stieva-A 0.01% crm, 0.025% crm, 0.05% crm, 0.1% forte Irritation: TAZ > TRE* >ADA After successful course, consider step-down to less frequent (q2-3 night) maintenance tx after wash; start 21 {continue till no Micro crm, 0.01% gel, 0.025% gel, 0.05% gel, 0.025% soln; *(except Retin-A Micro) + ⊗χ TRE 0.025% Vitamin A esp. for TRE & TAZ tretinoin 0.01%, 0.025%, 0.05%, 0.1% $40/45g cr low conc. ; new lesions} :Use sunscreen SPF 15-30 {Retisol A: SPF-15 } Acid 0.01% crm, 0.025% crm, 0.05% crm, 0.1% crm, 0.01% gel, 0.025% {TAZ often reserved for tough skin areas, or a DI: ↑ skin irritation or drying effect– concomitant topical medication, medicated apply q2-3 nights gel, 0.05% gel {0.025-0.05% useful/tolerated} initially to ↓SE. ADA: desire for strong therapy despite irritation} 2-4 weeks: abrasive soaps & cleansers, soaps & cosmetics with strong drying effect; products 45g {Pregnancy: Motherisk deems fairly safe} May give ADA in 40 Retinoid clinical with high concentrations of alcohol, astringents, spices or lime; isotretinoin ADAPALENE = ADA Serious: rare true contact allergy less photosensitivity 16 AM ⊗ χ C worsening ↓ noninflammatory & inflammatory lesions counts by 38-71% Differin 0.1% crm & gel (XP 0.3% gel ) CI eczema; pregnancy; √ TAZ may be effective TAZ: Wχ 0.04% gel, 0.1% gel $35 (may be useful near eyes?; anti-aging?) 30g TAZAROTENE = TAZ sunburn may be less with adapalene may occur Retin-A Micro emollient, less penetrating/irritation with <5 min contact, 54 X -may wish to stop for 1 week before a sunny vacation Renova⊗χ 0.05% crm indicated for fine wrinkles, mottled hyperpigmentation & roughness of skin (not acne) Tazorac 0.05 & 0.1% crm, gel thus reducing irritation 60ml Clindamycin = CLI; Topical Soln : less irritating than BP & TRE, 8-12 weeks √Most effective for inflammatory lesions. Stop when/if no further inflammation. Dalacin T: BID 24 Common ⊗ Dalacin T, g 10mg/ml; Clindets 1% χ; erythema, peeling, itching, dryness & burning17 for noted Use in combination with BP to prevent bacterial resistance !!!18,19,20 Clindets: BID 4860s ⊗ rare CLI 1% Cream & SPF-15 Clindasol χ Serious: PMC improvement √Most effective when used in combination with BP or topical retinoids21,22,23,24 Clindets CI CLI – previous colitis, regional Erythromycin = ERY B {CLI may be preferred over ERY for prolonged effect &/or less resistance} Expert Opinion Antibiotic ⊗ χ enteritis, ulcerative colitis, PMC ERY: OD-BID 2625g Erysol 2% gel contains SPF-15 sunscreen ⊗ = 17 18,25 Benzamycin BP 5%/ERY 3% gel * As for individual ingredients above. 2-4 weeks for √BP combined with ERY or CLI has not shown resistance Similar or ↑ efficacy. Benzamycin: qHS- 46.6g * 60 corticosteroid BID ⊗ ⊗ {for Neomedrol : burning sensation, itching, noted Refrigerate Benzamycin (3 month expiry); Clindoxyl at room temp (4 mo. expiry) BenzaClin , Clindoxyl = BP 5%/CLI 1% gel * * 50g -50g Pump irritation, dryness, folliculitis, acneiform eruptions, improvement; BenzaClin: qHS-BID 58 : Combinations that are not generally recommended for long-term acne treatment: s χ W Stievamycin gel = TRE+ERY hypopigmentation; rare true contact allergy} 8-10 weeks ⊗χ NEOSPORIN 0.25%/ METHYLPREDNISOLONE 0.25%; OD-BID 75ml * Neo-Medrol Acne Lotion ; may exacerbate acne $24 Clindoxyl: qHS-BID 45g TRE 0.01%/ERY 4% C 53 Mild , ⊗ [BP/CLI combination no better than BP alone for optimal Sulfacet-R Lotion = SS 10%/Sul 5%; BID-TID; acne:less efficacious; useful: acne rosacea $33 25g Regular TRE 0.025%/ERY 4%, McKeage Combination for non-inflammatory acne ] results (tinted preparation may be useful as camouflage) Stievamycin: QHS 2225g Forte TRE 0.05%/ERY 4% Salicylic Acid = SAW χ 0.5, 1, 2 & 3.5% Oxy, Clearasil, Neutrogena, others Æ:Not commonly recommended (less potent than equal strength BP); option if retinoid intolerance e.g. skin irritation OD or BID 10-15 χ=Non-form Sk =Exception Drug Status Sk ⊗=not covered by NIHB W=covered by NIHB Δ=change ABX=antibiotic crm=cream DI=drug interaction H2O=water MET=methylprednisolone NEO=neomycin OTC= over-the-counter PMC= Pseudomembranous colitis SS=sodium sulfacetamide Sul=sulfur Rx=prescription ◊Adjunctive BP ± Retinoids ± topical Antibiotics is beneficial ^Benzac AC: ACrylates Polymer =microscopic beads that absorb excess oil while releasing a small amount of glycerine to moisturize the skin.
Load more

Recommended publications
  • Targeted Topical Delivery of Retinoids in the Management of Acne Vulgaris: Current Formulations and Novel Delivery Systems
    pharmaceutics Review Targeted Topical Delivery of Retinoids in the Management of Acne Vulgaris: Current Formulations and Novel Delivery Systems Gemma Latter 1, Jeffrey E. Grice 2, Yousuf Mohammed 2 , Michael S. Roberts 2,3 and Heather A. E. Benson 1,* 1 School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth 6845, Australia; [email protected] 2 Therapeutics Research Group, The University of Queensland Diamantina Institute, School of Medicine, University of Queensland, Translational Research Institute, Brisbane 4109, Australia; jeff[email protected] (J.E.G.); [email protected] (Y.M.); [email protected] (M.S.R.) 3 School of Pharmacy and Medical Sciences, University of South Australia, Basil Hetzel Institute for Translational Health Research, Adelaide 5011, Australia * Correspondence: [email protected]; Tel.: +61-8-9266-2338 Received: 19 August 2019; Accepted: 17 September 2019; Published: 24 September 2019 Abstract: Acne vulgaris is a common inflammatory pilosebaceous condition that affects 80–90% of adolescents. Since the introduction of tretinoin over 40 years ago, topical retinoid products have been a mainstay of acne treatment. The retinoids are very effective in addressing multiple aspects of the acne pathology as they are comedolytic and anti-inflammatory, and do not contribute to antibiotic resistance or microbiome disturbance that can be associated with long-term antibiotic therapies that are a common alternative treatment. However, topical retinoids are associated with skin dryness, erythema and pain, and may exacerbate dermatitis or eczema. Thus, there is a clear need to target delivery of the retinoids to the pilosebaceous units to increase efficacy and minimise side effects in surrounding skin tissue.
    [Show full text]
  • Cumulative Irritation Comparison of Adapalene Gel and Solution with 2 Tazarotene Gels and 3 Tretinoin Formulations
    THERAPEUTICS FOR THE CLINICIAN Cumulative Irritation Comparison of Adapalene Gel and Solution With 2 Tazarotene Gels and 3 Tretinoin Formulations Alan Greenspan, MD; Christian Loesche, MD; Nancy Vendetti; Kathleen Georgeian; Richard Gilbert, PhD; Michel Poncet, PhD; Michael D. Baker, BS; Pascale Soto, RPh Forty-two subjects with normal skin were enrolled gel 0.025%, and 1 discontinued adapalene in a single-center study to assess the cumula- gel 0.1%. None of the subjects discontinued use tive irritancy potential of adapalene (Differin® of the white petrolatum or the adapalene solu- gel 0.1% and Differin solution 0.1%) compared tion 0.1%. Adapalene gel and solution 0.1% with tazarotene (Tazorac® gels 0.05% and 0.1%), were statistically (PϽ.01) less irritating than tretinoin (Retin-A Micro® gel 0.1%, Avita® cream both tazarotene gels 0.1% and 0.05%, tretinoin 0.025%, and Avita gel 0.025%), and white petro- microsphere gel 0.1%, and tretinoin gel 0.025%, latum (negative control). All test materials were and they were not statistically different from applied randomly, under occlusion, to sites tretinoin gel 0.025%. located on either side of the midline— the mid Cutis. 2003;72:76-81. thoracic area of the subjects’ backs. All patches were applied daily, Monday through Friday, to dapalene (Differin®) is a naphthoic-acid the same sites, unless the degree of reaction to derivative with retinoid activity that is a test product or adhesive necessitated removal A effective in the treatment of mild to moder- (grade 3). ate acne vulgaris.1-4 Adapalene, in both gel and Thirty-eight of the 42 subjects (90.5%) com- cream formulations, at the marketed and approved pleted the study.
    [Show full text]
  • Proactiv Skin Smoothing Exfoliator Vs Renewing Cleanser
    Proactiv Skin Smoothing Exfoliator Vs Renewing Cleanser garefowlsExtensible and and foster obumbrate proconsulship. Elijah debug, How but pyroligneous Zacharia genealogically is Kristian when roughhouse Uralian and her succulent diet. Cold-bloodedly Huey taxi some archaistic, kit? Charlie trippings Starter size os at their treatment ensures complete an idea of acne blemishes and redness or peeling occurs, brokerage and then here Does it burns on a diyi organic aloe barbadensis leaf juice and proactiv skin smoothing exfoliator vs renewing cleanser and can remain the benzoyl peroxide, leave a freelance beauty editors rated it! Here are something different types of pimples and how to betray them. Apply the mask to west, dry skin, focusing on problem areas such as their forehead, nose cheek chin. In higher doses it can be a skin irritant. Service worker registration succeeded. Treat both whole face. Free trial today my face moisturizer reviews online in proactiv skin smoothing exfoliator vs renewing cleanser and proactiv plus, the poshmark new pimples even more expensive than their face. How various Use Proactiv Refining Mask LEAFtv. Upi id below letting me years ago, proactiv renewing cleanser twice a valid credit, the smoothing exfoliator, will be expensive choice. It and the most frustrating skin healthy skin cakey the hassle of proactiv skin smoothing exfoliator vs renewing cleanser. We evaluate on this treatment kits to help keep in the bank to pay the part is a wallet spend limits or proactiv skin smoothing exfoliator vs renewing cleanser and gradually increase application to the! Proactiv Renewing Cleanser This acne-fighting cleanser washes away with oil dirt and other impurities.
    [Show full text]
  • 1 EMA Tender EMA/2017/09/PE, Lot 2 Impact of EU Label
    EMA tender EMA/2017/09/PE, Lot 2 Impact of EU label changes and revised pregnancy prevention programme for oral retinoid containing medicinal products: risk awareness and adherence Protocol • Prof. Anna Birna Almarsdóttir, Professor in Social and Clinical Pharmacy at the Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen • Prof. Marcel Bouvy, Professor of Pharmaceutical Care at the Division of Pharmacoepidemiology & Clinical Pharmacology of the Department of Pharmaceutical Sciences, Utrecht University. • Dr Rob Heerdink, Associate Professor at the Division of Pharmacoepidemiology & Clinical Pharmacology of the Department of Pharmaceutical Sciences, Utrecht University. • Dr Teresa Leonardo Alves, Researcher at the Centre for Health Protection, National Institute for Public Health and the Environment, The Netherlands. 1 Table of contents Background ...................................................................................................................... 3 Aims of the study ............................................................................................................. 4 Methods ........................................................................................................................... 4 Setting ........................................................................................... Error! Bookmark not defined. Study design ............................................................................................................................ 4 Population
    [Show full text]
  • Aetna Formulary Exclusions Drug List
    Covered and non-covered drugs Drugs not covered – and their covered alternatives 2020 Advanced Control Plan – Aetna Formulary Exclusions Drug List 05.03.525.1B (7/20) Below is a list of medications that will not be covered without a Key prior authorization for medical necessity. If you continue using one of these drugs without prior approval, you may be required UPPERCASE Brand-name medicine to pay the full cost. Ask your doctor to choose one of the generic lowercase italics Generic medicine or brand formulary options listed below. Preferred Options For Excluded Medications1 Excluded drug name(s) Preferred option(s) ABILIFY aripiprazole, clozapine, olanzapine, quetiapine, quetiapine ext-rel, risperidone, ziprasidone, VRAYLAR ABSORICA isotretinoin ACANYA adapalene, benzoyl peroxide, clindamycin gel (except NDC^ 68682046275), clindamycin solution, clindamycin-benzoyl peroxide, erythromycin solution, erythromycin-benzoyl peroxide, tretinoin, EPIDUO, ONEXTON, TAZORAC ACIPHEX, esomeprazole, lansoprazole, omeprazole, pantoprazole, DEXILANT ACIPHEX SPRINKLE ACTICLATE doxycycline hyclate capsule, doxycycline hyclate tablet (except doxycycline hyclate tablet 50 mg [NDC^ 72143021160 only], 75 mg, 150 mg), minocycline, tetracycline ACTOS pioglitazone ACUVAIL bromfenac, diclofenac, ketorolac, PROLENSA acyclovir cream acyclovir (except acyclovir cream), valacyclovir ADCIRCA sildenafil, tadalafil ADZENYS XR-ODT amphetamine-dextroamphetamine mixed salts ext-rel†, dexmethylphenidate ext-rel, dextroamphetamine ext-rel, methylphenidate ext-rel†, MYDAYIS,
    [Show full text]
  • Estonian Statistics on Medicines 2016 1/41
    Estonian Statistics on Medicines 2016 ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A ALIMENTARY TRACT AND METABOLISM 167,8985 A01 STOMATOLOGICAL PREPARATIONS 0,0738 A01A STOMATOLOGICAL PREPARATIONS 0,0738 A01AB Antiinfectives and antiseptics for local oral treatment 0,0738 A01AB09 Miconazole (O) 7088 g 0,2 g 0,0738 A01AB12 Hexetidine (O) 1951200 ml A01AB81 Neomycin+ Benzocaine (dental) 30200 pieces A01AB82 Demeclocycline+ Triamcinolone (dental) 680 g A01AC Corticosteroids for local oral treatment A01AC81 Dexamethasone+ Thymol (dental) 3094 ml A01AD Other agents for local oral treatment A01AD80 Lidocaine+ Cetylpyridinium chloride (gingival) 227150 g A01AD81 Lidocaine+ Cetrimide (O) 30900 g A01AD82 Choline salicylate (O) 864720 pieces A01AD83 Lidocaine+ Chamomille extract (O) 370080 g A01AD90 Lidocaine+ Paraformaldehyde (dental) 405 g A02 DRUGS FOR ACID RELATED DISORDERS 47,1312 A02A ANTACIDS 1,0133 Combinations and complexes of aluminium, calcium and A02AD 1,0133 magnesium compounds A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 811120 pieces 10 pieces 0,1689 A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 3101974 ml 50 ml 0,1292 A02AD83 Calcium carbonate+ Magnesium carbonate (O) 3434232 pieces 10 pieces 0,7152 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 46,1179 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 2,3855 A02BA02 Ranitidine (O) 340327,5 g 0,3 g 2,3624 A02BA02 Ranitidine (P) 3318,25 g 0,3 g 0,0230 A02BC Proton pump inhibitors 43,7324 A02BC01 Omeprazole
    [Show full text]
  • The Role of Specific Retinoid Receptors in Sebocyte Growth And
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector The Role of Speci®c Retinoid Receptors in Sebocyte Growth and Differentiation in Culture1 Mi-Jung Kim, Nancy Ciletti, Serge Michel,* Uwe Reichert,* and Robert L. Rosen®eld Departments of Pediatrics and Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, U.S.A.; *Galderma R&D, Sophia Antipolis, France Retinoic acid derivatives (retinoids) exert their pleio- (42.2 6 4.0% vs 22.6 6 2.7%, mean 6 SEM, lipid- tropic effects on cell development through speci®c forming colonies, p < 0.01). Furthermore, the RAR- nuclear receptors, the retinoic acid receptors and b,g antagonist CD2665 antagonized the suppressive retinoid X receptors. Despite recent progress in effects of all-trans retinoic acid, adapalene, and understanding the cellular and molecular mechan- CD2043 on both cell growth and differentiation. In isms of retinoid activity, it is unknown which of the contrast, the retinoid X receptor agonist CD2809 retinoid receptor pathways are involved in the speci- increased cell growth slightly and lipid-forming colo- ®c processes of sebocyte growth and development. nies dramatically in a clear dose-related manner to a In this study, we investigated the roles of speci®c maximum of 73.7% 6 6.7% at 10±6 M (p < 0.001). retinoid receptors in sebocyte growth and differen- Our data suggest that retinoic acid receptors and tiation, by testing the effects of selective retinoic acid retinoid X receptors differ in their roles in sebocyte receptor and retinoid X receptor ligands at concen- growth and differentiation: (i) retinoic acid recep- trations between 10±10 M and 10±6 M in a primary rat tors, especially the b and/or g subtypes, mediate preputial cell monolayer culture system.
    [Show full text]
  • Benzoyl Peroxide Vs. Salicylic Acid WHAT to USE and WHEN
    benzoyl peroxide vs. salicylic acid WHAT TO USE AND WHEN BENZOYL PEROXIDE AND SALICYLIC ACID ARE THE TWO MAIN INGREDIENTS IN MOSI OVER-THE-COUNTER TOPICAL ACNE PRODUCTS. BUT HOW DO THEY WORK, HOW ARE qr' THEY DIFFERENT AND WHICH ONE IS RIGHT FOR YOU7 > salicylic acid PREVENTS CLOGGED PORES BY AIDING ExFoLImIoN Atne forms wheh skin ceUs inside the hair falltck clump together and phq up the fulUcle. Salicylic HOW TO USE acid help sped cot1 twrnovgr on the surfate and slow the shedding of cells inside the foliicte tcr I.i pkwnt the clogging that causes a pimple. 5~lieylicacid aLo breaks down whiteheads ad San Francisco dermatologist blackheads. Technicalty a beta hydraxy acid, salicylic acid exfoliates and reduces oiliness, acne and Kathy Fields. MD, recommends 4 the appeal-nee of fine lines. It Is availableover-thecaunter in concentrstiom of 0.5 ta 246. but those a leave-on product or gentle , with sensitive skin shwld start with a lcHnier contentratton before trying stronger prcrducts. scrub or wash that doesn't strip ' the skin of moisture. "The key is to find a product you like using so you stick with it." she says. This ingredient can be irritating to sensitive skin, especially when combined with benzoyl peroxide, sulfur or other acne treatments. Mild stinging upon application is common. Salicylic acid may cause increased sun sensitivity, so be sure to use sunscreen daily. Salicylic acid must be used con- tinuously for results. If you stop, your pores will get clogged once again and your acne will return. KINERASE CLEAR SKlX w6xLERAGNOSw MWiUo CUIIEtFflNG Salicylic acid does not have an BLtSHlSH OIssOlVER OVERNIM ACNE CtEAmml effect on the production of REPAIR LOTION This spot treatment contains In addition to salitylic acid, sebum Ithe skin's natural oil], salicylic acid and glycolic acid Fight acne and aging with one this daily cleanser contains tri- or P.
    [Show full text]
  • Topical Acne Treatments and Pregnancy
    Topical Acne Treatments This sheet talks about exposure to topical acne treatments in a pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare provider. What are topical acne treatments? Topical acne treatments are medications that are put directly on the skin. Topical acne treatments can be over-the- counter or prescription. Common active ingredients are benzoyl peroxide, azelaic acid, glycolic acid, and salicylic acid. Prescription acne medications include tretinoin, adapalene, dapsone, and antibiotics such as erythromycin and clindamycin. Can I use tretinoin (Retin A®) for severe acne during my pregnancy? Tretinoin is different from other topical treatments that will be discussed here. It belongs to a group of medications called retinoids, which can cause birth defects when taken by mouth. The amount of tretinoin absorbed through the skin is low, and studies have reported that women who used topical tretinoin during pregnancy did not have an increased chance for birth defects. However, due to the theoretical concerns and the availability of other topical acne products, tretinoin use is discouraged during pregnancy. Please refer to the MotherToBaby fact sheet Tretinoin at https://mothertobaby.org/fact-sheets/tretinoin-retin-a-pregnancy/pdf/ and Isotretinoin at https://mothertobaby.org/fact-sheets/isotretinoin-accutane-pregnancy/pdf/ for more information on this group of medications. Can I use adapalene gel during my pregnancy? Adapalene is a retinoid in the same group of medications as tretinoin. Studies have shown that only a small amount is absorbed through the skin when adapalene gel is used. Studies looking at adapalene in pregnancy include only a very small number of exposed pregnancies therefore, more studies are needed.
    [Show full text]
  • Cumulative Irritation Potential of Adapalene 0.1% Cream and Gel Compared with Tazarotene Cream 0.05% and 0.1%
    THERAPEUTICS FOR THE CLINICIAN Cumulative Irritation Potential of Adapalene 0.1% Cream and Gel Compared With Tazarotene Cream 0.05% and 0.1% Jonathan S. Dosik, MD; Kenneth Homer, MS; Stéphanie Arsonnaud Despite the many beneficial effects of dermato- The mean 21-day cumulative irritancy indices for logic applications, most of the current treatments adapalene 0.1% cream and gel were significantly for acne cause local irritation. The objective of lower (Pϭ.05) than those for tazarotene cream this study was to compare the ability of the epi- 0.05% and 0.1% and not notably higher than that of dermis to tolerate adapalene 0.1% cream and gel the negative control product. and tazarotene cream in concentrations of 0.05% Cutis. 2005;75:289-293. and 0.1%. A total of 30 subjects were enrolled in the study. The test products were applied under occlusive dressings at randomized sites on the cne vulgaris is the most common dermato- upper back for approximately 24 hours, 4 times logic disorder, affecting approximately 85% a week, and for 72 hours, once a week, for a A of individuals at some time between the ages period of 3 weeks. Skin reactions (erythema of 12 and 14 years.1 Although acne is most preva- score plus other local reactions) at the product lent in this age group, the disease is reported in application sites were assessed 15 to 30 minutes 8% of adults between the ages of 25 and 34 years after dressing removal. and in 3% of adults between the ages of 35 and Twenty-six subjects completed the study.
    [Show full text]
  • Proactiv Oil Free Moisture En Espanol
    Proactiv oil free moisture en espanol click here to download "The Oil Free Moisture is great. It's got sunscreen in it, so you always feel like you're protected when you are outside. And it's really light. It doesn't feel like you've. Proactiv Oil Free Moisturizer Review. Drugstore Review & Comparison: Neutrogena Moisturizers: Oil Free. Find great deals on eBay for Proactiv Oil Free Moisture in Acne and Blemish Control for Skin Care. Shop with confidence. Oil Free Moisture With Broad Spectrum SPF Whatever your skin type, a daily moisturizer can actually improve the look and texture of your skin, giving you a. Proactiv Solution Oil Control Kit. With the Oil Free Moisture and Advanced Daily Oil Control products, your skin is clean, clear and hydrated. Key Ingredients. Oil Free Moisture Broad Spectrum SPF 15 is a lightweight formula that helps to absorb excess oil for a smoother matte-looking finish and protects against sun. Proactiv Oil-Free Moisture Broad Spectrum SPF 15 is designed to reduce the appearance of shine while hydrating the skin. This lightweight formula is. Find helpful customer reviews and review ratings for Proactiv Oil Free Moisture with Broad Spectrum SPF 15 - oz. at www.doorway.ru Read honest and. The American proactiv oil free moisture en espanol for the UN was the s of the Informal Agenda Group, known in by Secretary of State Cordell Hull. www.doorway.ru members rated Proactiv Solution Oil-Free Moisture with SPF 15 an average of /5 and 59% of members would recommend it to a friend.
    [Show full text]
  • Written Submissions of Board Staff
    PATENTED MEDICINE PRICES REVIEW BOARD IN THE MATTER OF the Patent Act R.S.C. 1985, c. P-4 as amended IN THE MATTER OF the Medicines DIFFERIN® (adapalene) DIFFERIN XP® (adapalene) TACTUPUMP® (adapalene/benzoyl peroxide) TACTUPUMP FORTE® (adapalene/benzoyl peroxide) (Collectively, " the Adapalene Medicines" ) Sold in Canada by GALDERMA CANADA Inc. (the "Respondent") WRITTEN SUBMISSIONS OF BOARD STAFF Conway Baxter Wilson LLP/s.r.l. 401-1111 Prince of Wales Dr. Ottawa, ON K2C 3T2 David K. Wilson [email protected] Calina Ritchie [email protected] Julie Mouris [email protected] Tel: 613-288-0149 Fax: 613-688-0271 Lawyers for Board Staff Table of Contents PART I - SUMMARY AND ORDER SOUGHT ...................................................................................... 2 PART II - BACKGROUND OF THIS APPLICATION .............................................................................. 6 A. The Adapalene Medicines and Acne Vulgaris ...................................................................... 6 Differin and Differin XP................................................................................................... 8 TactuPump and TactuPump Forte.................................................................................. 9 B. Adapalene Medicines and the Anatomical Therapeutic Classification (ATC) System ......... 9 C. Adapalene and Clinical Treatment Considerations ........................................................... 11 D. The Patents at Issue ..........................................................................................................
    [Show full text]