Epileptic Seizures Explained
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Unlocking the Brain
epilepsytoday Issue 143 September 2019 • £4.25 (free to members) Rescued by first-aid Discover how Jane’s friends and family made a difference when she needed first-aid Also in this issue • Professor Mark Richardson talks next-gen seizure detection devices • Case studies on finding work and employment • Latest research findings from the GGE conference epilepsy feature technologies have shown to have the Unlocking same performance in predicting seizures. That is why we are very motivated to promote the investigation of new the brain devices that are less invasive. Matt Ng speaks to Professor Mark Richardson, Long-term head of neuroscience at King’s College London. beneath-the-skin Mark discusses a new type of device that could EEG provides revolutionise seizure prediction a remarkable opportunity The technology to predict seizures in provided with real-time feedback about people with epilepsy is still in its infancy. their current level of seizure risk, using to record EEG Previous efforts have involved electrodes the device’s coloured lights. continuously placed invasively in direct contact with the brain. However, there is a new The study found the method was safe approach that could lead the way in and provided a reliable indication of Q: What new technology is effective seizure prediction for many. seizure risk for some of the people, so being developed to do this now? the concept was effective. However, the A: With the NeuroVista we looked at Q: What technology has been need for electrodes inside the skull was putting electrodes inside the skull. This used in the past to predict found too invasive and unfortunately, the solution involves placing electrodes seizures in an individual person? NeuroVista system is no longer available. -
Epilepsy and Communication
fasic England Gloss ry Epilepsy and communication Epilepsy is a chronic disorder of the brain • Temporal Lobe epilepsy characterised by recurrent seizures, which affects • Dravet syndrome people worldwide (WHO, 2016). The World Health Organisation deKnes a seizure as a transient loss of There are a range of communication difficulties function of all or part of the brain due to excessive associated with epilepsy. For some people, electrical discharges in a group of brain cells. Physical, communication difficulties can become more sensory or other functions can be temporarily lost. pronounced at times immediately before, during or after seizure activity. Epilepsy affects 1 in 177 young people under the age of 25 so there are around 112,000 young people with Communication difficulties may include: epilepsy in the UK (Joint Epilepsy Council, 2011). In 75% • Comprehension difficulties: Children may Knd it of people, seizures are well controlled with medication hard to understand what others are saying to but 25% continue to have seizures despite treatment. them or what is expected of them, and may struggle to understand environmental cues, daily Epilepsy can be linked with learning, behavioural and routines or activity sequences. speech and language difficulties. This is increasingly • Attention and listening difficulties: Children recognised and the risks are greater if epilepsy occurs may have difficulties in attending to spoken before 2 years of age. Parkinson (1994) found that language, or to an activity. from a small study of children referred for assessment of their epilepsy, 40% had undiagnosed language • Expressive difficulties: It may be hard for impairment of varying degrees of severity. -
The Art of Epilepsy Management
FOCAL EPILEPSY AND SEIZURE SEMIOLOGY Piradee Suwanpakdee, MD. Division of Neurology Department of Pediatrics Phramongkutklao Hospital OUTLINE • Focal onset seizure classification • The definition of semiology • How can we get the elements of semiology? Focal seizures • Originate within networks limited to one hemisphere • May be discretely localized or more widely distributed.… www.ilae.org What is the seizure semiology? • Seizure semiology is an expression of activation and disinhibition of cerebral areas • It thus provides some information what cerebral areas are “involved” during a seizure Symptomatogenic areas Left hemisphere lateral aspect Mesial aspect Symptomatogenic areas Left Insula How can we get the elements of seizure semiology? • The information on semiology comes from patient’s and witness’ history • Video EEG provides objective data on seizure semiology • Seizure classification aims to intellectually organise and summarise information about seizure semiology Notes • Atonic seizures and epileptic spasms would not have level of awareness specified • Pedalling grouped in hyperkinetic rather than automatisms (arbitrary) • Cognitive seizures • impaired language • other cognitive domains • positive features eg déjà vu, hallucinations, perceptual distortions • Emotional seizures: anxiety, fear, joy, etc Focal onset aware seizure • This term replaces simple partial seizure • A seizure that starts in one area of the brain and the person remains alert and able to interact is called a focal onset aware seizure. • These seizures are brief, lasting seconds to less than 2 minutes. Focal clonic seizure • Indicate involvement of contralateral primary motor cortex • Reliability is good Epilepsia partialis continua focal motor status involving a small portion of the sensorimotor cortex Focal Onset Impaired Awareness Seizures • A seizure that starts in one area of the brain and the person is not aware of their surroundings • Focal impaired awareness seizures typically last 1 to 2 minutes. -
Best Practice Guidelines for Training
Best practice guidelines for training professional carers in the administration of Buccal (Oromucosal) Midazolam for the treatment of prolonged and / or clusters of epileptic seizures in the community Safe & Effective | Kind & Caring | Exceeding Expectation Epilepsy Nurses Association (ESNA) June 2019 1. Foreword One of the most important components of epilepsy care is the pre-hospital community management of prolonged or repeated seizures, which, if untreated, can increase the risk of status epilepticus. Convulsive status epilepticus is a medical emergency requiring admission to hospital and has a mortality rate of up to 20 per cent. Effective management of seizures in the community in people at high risk of status epilepticus could significantly reduce mortality, morbidity and emergency health care utilisation. The Joint Epilepsy Council issued guidance until it was disbanded in 2015, leaving a vacuum in the review and update of clinical guidelines. Unfortunately, the clinical processes ensuring the safety and consistency of buccal midazolam usage demonstrates considerable heterogeneity. There are no current guidelines, standards or pathways to ensure the safety of all involved in the process i.e. patient, carer or professional. ESNA is an organisation principally formed by nurses with an interest in epilepsy. Most ESNA members support or complete training for buccal midazolam to ensure core competencies are up to date and patient safety is protected. ESNA is joined by the International League Against Epilepsy (British Chapter) and the Royal College of Psychiatrists (ID Faculty) as the other principal specialist clinical stakeholders with an interest to ensure governance in this complex care area is addressed robustly. ESNA has collaborated with the ILAE and the Royal College of Psychiatrists to produce updated buccal midazolam guidance. -
Clinicians Using the Classification Will Identify a Seizure As Focal Or Generalized Onset If There Is About an 80% Confidence Level About the Type of Onset
GENERALIZED ONSET SEIZURES Generalized onset seizures are not characterized by level of awareness, because awareness is almost always impaired. Generalized tonic-clonic: Immediate loss of Generalized epileptic spasms: Brief seizures with awareness, with stiffening of all limbs (tonic phase), flexion at the trunk and flexion or extension of the followed by sustained rhythmic jerking of limbs and limbs. Video-EEG recording may be required to face (clonic phase). Duration is typically 1 to 3 minutes. determine focal versus generalized onset. The seizure may produce a cry at the start, falling, tongue biting, and incontinence. Generalized typical absence: Sudden onset when activity stops with a brief pause and staring, Generalized clonic: Rhythmical sustained jerking of sometimes with eye fluttering and head nodding or limbs and/or head with no tonic stiffening phase. other automatic behaviors. If it lasts for more than These seizures most often occur in young children. several seconds, awareness and memory are impaired. Recovery is immediate. The EEG during these seizures Generalized tonic: Stiffening of all limbs, without always shows generalized spike-waves. clonic jerking. Generalized atypical absence: Like typical absence Generalized myoclonic: Irregular, unsustained jerking seizures, but may have slower onset and recovery and of limbs, face, eyes, or eyelids. The jerking of more pronounced changes in tone. Atypical absence generalized myoclonus may not always be left-right seizures can be difficult to distinguish from focal synchronous, but it occurs on both sides. impaired awareness seizures, but absence seizures usually recover more quickly and the EEG patterns are Generalized myoclonic-tonic-clonic: This seizure is like different. -
Epilepsy Specialist Nurses the Evidence (ESPENTE): a Systematic Mapping Review
Epilepsy Specialist Nurses The Evidence (ESPENTE): a Systematic Mapping Review Fiona Campbell, Katie Sworn, Andrew Booth, Markus Reuber, Richard Grünewald, Carina Mack, Jon M Dickson c/o ScHARR, Health Economics and Decision Science, University of Sheffield, Regent Court, 30 Regent Street, Sheffield. S1 4DA 8th July 2019 Epilepsy Specialist Nurses – A Mapping Review of The Evidence Foreword Epilepsy Specialist Nurses (ESNs) have been called ‘the glue that connects services to people with epilepsy’. Guidelines, such as those produced by the National Institute for Health and Care Excellence (NICE) and Scottish Intercollegiate Guidelines Network (SIGN) in the UK highlight the importance of ESNs to the care of people with epilepsy. They are in an ideal position to act as an expert resource and point of first contact for patients, carers and professionals alike. ESN roles are diverse across the three main sub-specialties: adult, paediatrics and learning disability. ESN involvement in epilepsy surgery pathways and multi-disciplinary teams has been identified as essential. Despite this, ESNs are still seen as an expensive luxury in some areas, with wide, geographical discrepancies in UK service provision. Documents such as the ESN Competencies, developed by the Epilepsy Nurses Association (ESNA), describe the skills of nurses with different levels of knowledge and experience, in order to provide commissioners and (particularly new) ESNs with a greater understanding of the role. The ESPENTE study creates much needed context to the argument for the development of the ESN as an integral part of the care provided to people with epilepsy, their family and carers. It provides a critical review of the available evidence and, most importantly, highlights the limitations of the current, published literature, while identifying priorities for future studies. -
Seizure Disorders
Seizure Disorders Author Anthony Murro, M.D. Medical College of Georgia Epilepsy Program Department of Neurology Medical College of Georgia Augusta, GA 30912 Contents · Seizure Definitions · Types of Seizures · Partial Seizures · Generalized Seizures · Automatisms · Post-ictal state · Evolution of seizure type · Provoked Seizures · Causes of provoked seizures · Causes of unprovoked seizures · Electroencephalogram · Neuroimaging · Epilepsy syndromes o Temporal lobe epilepsy: o Frontal lobe epilepsy: o Occipital lobe epilepsy: o West Syndrome o Lennox Gastaut Syndrome o Benign partial epilepsy syndromes o Childhood absence epilepsy o Juvenile myoclonic epilepsy (JME) o Simple Febrile Seizure o Complex Febrile Seizure o Neonatal seizures · Anticonvulsant therapy o When to start and stop anticonvulsant therapy o Principles of anticonvulsant therapy o Anticonvulsant side effects o Phenytoin o Carbamazepine o Phenobarbital o Valproate o Lamotrigine o ACTH/Corticosteroid o Oxcarbazepine o Zonisamide · Status Epilepticus · Drug Therapy for status epilepticus · Epilepsy Surgery · Counseling and patient education · Self assessment examination · Examination answers · References · Disclaimer · Permitted Use Statement Seizure Definitions · An epileptic seizure is a disorder of abnormal synchronous electrical brain activity. · A clinical seizure is a epileptic seizure with symptoms. · A subclinical seizure is a epileptic seizure without symptoms. · A non-epileptic seizure (pseudoseizure) is a disorder with symptoms similar to a epileptic seizure. However, a non-epileptic seizure is not caused by abnormal synchronous electrical brain activity. · A cryptogenic seizure is a seizure that occurs from an unknown cause. Older publications use idiopathic to describe a seizure of unknown etiology but the current ILAE guidelines discourage the use of idiopathic for describing a seizure of unknown etiology. · A symptomatic seizure is a seizure that occurs from a known or suspected brain insult known to increase the risk of developing epilepsy. -
ICTALS2019 the Epilepsy Journey
ICTALS2019 The Epilepsy Journey 2-5 September In partnership with Abstract book This conference is supported by a grant from the American Epilepsy Society ICTALS2019 The Epilepsy Journey Foreword The International Conference for Technology and Analysis of Seizures, 2019 (ICTALS2019) aims to bring together neurologists, neuroscientists, researchers from quantitative disciplines and people with lived experience of epilepsy in order to work as a community to advance our understanding of epilepsy and develop practical ways to improve diagnosis and treatment. The theme for this year’s conference is: The Epilepsy Journey: from first seizure to treatment and beyond. We will emphasise how advances in our understanding of the dynamics of brain networks can be used to make a difference to people with epilepsy at all points of their journey: from elucidating the causes of the first seizure to diagnosing epilepsy, understanding how ictogenic networks give rise to recurrent seizures and how this insight can inform personalised treatment. To encourage this focus on the whole epilepsy journey we seek to include all relevant communities. In addition to discussions on current scientific, clinical and technological advances, we will take steps to increase accessibility for people with lived experience of epilepsy. Dates: Monday 2 September 2019 - Thursday 5 September 2019 Venue: University of Exeter, Streatham Campus, Xfi Building Conference website: http://ex.ac.uk/ictals2019 Contact the organisers: [email protected] ICTALS2019 The Epilepsy Journey Partners We are partnering with charities Epilepsy Research UK and Epilepsy Action and Alliance for Epilepsy Research. Sponsors This event would not be possible without the generous contributions from our generous sponsors UCB, the Epilepsy Foundation, NeuraLynx, and Liva Nova. -
Epilepsy Syndromes E9 (1)
EPILEPSY SYNDROMES E9 (1) Epilepsy Syndromes Last updated: September 9, 2021 CLASSIFICATION .......................................................................................................................................... 2 LOCALIZATION-RELATED (FOCAL) EPILEPSY SYNDROMES ........................................................................ 3 TEMPORAL LOBE EPILEPSY (TLE) ............................................................................................................... 3 Epidemiology ......................................................................................................................................... 3 Etiology, Pathology ................................................................................................................................ 3 Clinical Features ..................................................................................................................................... 7 Diagnosis ................................................................................................................................................ 8 Treatment ............................................................................................................................................. 15 EXTRATEMPORAL NEOCORTICAL EPILEPSY ............................................................................................... 16 Etiology ................................................................................................................................................ 16 -
Report of the ILAE Classification Core Group
Epilepsia, 47(9):1558–1568, 2006 Blackwell Publishing, Inc. C 2006 International League Against Epilepsy Special Article Report of the ILAE Classification Core Group Jerome Engel, Jr., Chair Reed Neurological Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, U.S.A. Summary: A Core Group of the Task Force on Classification is to present a list of seizure types and syndromes to the ILAE and Terminology has evaluated the lists of epileptic seizure types Executive Committee for approval as testable working hypothe- and epilepsy syndromes approved by the General Assembly in ses, subject to verification, falsification, and revision. This re- Buenos Aires in 2001, and considered possible alternative sys- port represents completion of this work. If sufficient evidence tems of classification. No new classification has as yet been subsequently becomes available to disprove any hypothesis, the proposed. Because the 1981 classification of epileptic seizure seizure type or syndrome will be reevaluated and revised or dis- types, and the 1989 classification of epilepsy syndromes and carded, with Executive Committee approval. The recognition of epilepsies are generally accepted and workable, they will not specific seizure types and syndromes, as well as any change be discarded unless, and until, clearly better classifications have in classification of seizure types and syndromes, therefore, will been devised, although periodic modifications to the current clas- continue to be an ongoing dynamic process. A major purpose of sifications may be suggested. At this time, however, the Core this approach is to identify research necessary to clarify remain- Group has focused on establishing scientifically rigorous cri- ing issues of uncertainty, and to pave the way for new classifica- teria for identification of specific epileptic seizure types and tions. -
Epilepsy February 15, 2007 the World’S Most Common Serious Neurological Disorder
EPILEPSY FEBRUARY 15, 2007 THE WORLD’S MOST COMMON SERIOUS NEUROLOGICAL DISORDER AN INDEPENDENT SUPPLEMENT FROM MEDIAPLANET ABOUT EPILEPSY, DISTRIBUTED WITHIN THE TIMES 2 AN INDEPENDENT SUPPLEMENT FROM MEDIAPLANET ABOUT EPILEPSY, DISTRIBUTED IN THE TIMES CONTENTS Epilepsy – an individual condition p. 4 Finally seizure free p. 5 Diagnosis p. 6 Epilepsy in children and young people p. 7 Epilepsy in women p. 8 Living with epilepsy p. 9 Brain imaging & epilepsy p.10 Genetics research p.12 A global perspective p.13 SUDEP p.13 Therapies & treatment options p.14 Helen Hollis – liberated by surgery p.15 Vagus nerve stimulation p.16 Coping with memory loss p.16 Government initiatives p.17 Economic burden p.17 Who looks after your epilepsy? p.18 Welcome to Epilepsy Resources & helplines p.19 Epilepsy is the most common serious disorder that affects the brain. One are likely to have adverse effects or not. The combination of sophisticat- person in 20 will have an epileptic seizure sometime in their life and 50 ed brain imaging and genetic analysis, with the traditional tools of a per 100,000 people develop epilepsy every year. In the UK, this translates detailed clinical history, video recording of seizures and study of the to 450,000 having epilepsy at the present and 30,000 developing it every brain’s electrical rhythms with the electroencephalogram (EEG) are now year. Whilst two thirds of those who develop epilepsy have the condition allowing us to individualise therapy for each person so they have the www.mediaplanetgroup.co.uk controlled with medication, the remainder do not do so well and continue best possible chance of control of their epilepsy without side-effects to have seizures. -
Epilepsy & My Child Toolkit
Epilepsy & My Child Toolkit A Resource for Parents with a Newly Diagnosed Child 136EMC Epilepsy & My Child Toolkit A Resource for Parents with a Newly Diagnosed Child “Obstacles are the things we see when we take our eyes off our goals.” -Zig Ziglar EPILEPSY & MY CHILD TOOLKIT • TABLE OF CONTENTS Introduction Purpose .............................................................................................................................................5 How to Use This Toolkit ....................................................................................................................5 About Epilepsy What is Epilepsy? ..............................................................................................................................7 What is a Seizure? .............................................................................................................................8 Myths & Facts ...................................................................................................................................8 How is Epilepsy Diagnosed? ............................................................................................................9 How is Epilepsy Treated? ..................................................................................................................10 Managing Epilepsy How Can You Help Manage Your Child’s Care? ...............................................................................13 What Should You Do if Your Child has a Seizure? ............................................................................14