GUIDE CELL Attraction Repulsion Key Activation / Indirect Attraction Signalling pathways initiated by: Stimulation Effect Repulsion Netrins Slits Inhibition Binding Outgrowth Ephrins Semaphorins

Ig Sema CUB Ig Ligand Sema binding I-like Ig PSI Factor Ig domain FN III FN III V/VIll PSI FN III Hybrid IPT MAM LRR TSP IPT PSI domain FN III IPT IEGF TK C2 set CC0 CC0 DB SAM SP CC1 β tail CC2 CC2 ZUS SP P1 CC3 CC3 TK P2 PDZ DD P3

Ca2+

Microtubule reorganization

Regulation of Regulation of Regulation of actin cytoskeleton actin cytoskeleton actin cytoskeleton

Attraction Reference Repulsion Outgrowth ● Yu, T.W., and Bargmann, C.I. (2001). Dynamic regulation of axon guidance. Nature Neuroscience 4,1169-76. ● Dickson, B.J. (2002). Molecular mechanisms of axon guidance. Science 298,1959-1964. ● Kruger, R.P., Aurandt, J., and Guan, K.L. (2005). Semaphorins command cells to move. Nature Reviews Molecular Cell Biology 6, 789-800. ● Cirulli, V., and Yebra, M. (2007). Netrins: beyond the brain. Nature Reviews Molecular Cell Biology 8, 296-306. ● Kanehisa, M., Goto, S., Furumichi, M., Tanabe, M., and Hirakawa, M. (2010). KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acid Research 38, D355-D360. GROWTH CONE OF AXON www.abnova.com Email: [email protected] Tel: + 886 2 8751 1888 Fax: + 886 2 8751 1166 Copyright © 2010 Abnova, All Rights Reserved. 650+ Antibodies for Axon Guidance

PAB16983 ABL1 polyclonal antibody ELISA,IHC-P,WB-Ce H00004775-M02 NFATC3 monoclonal antibody (M02), clone 3A12 ELISA,IHC-P,S-ELISA H00003983-M01A ABLIM1 monoclonal antibody (M01A), clone 3A1 ELISA,WB-Re H00004776-D01P NFATC4 purified MaxPab rabbit polyclonal antibody (D01P) Det Ab,PLA-Ce,WB-Tr H00022885-B01P ABLIM3 purified MaxPab mouse polyclonal antibody (B01P) Det Ab,WB-Tr H00004893-M01 NRAS monoclonal antibody (M01), clone 2A3 ELISA,S-ELISA,WB-Re H00023365-A01 ARHGEF12 polyclonal antibody (A01) ELISA,WB-Re H00008829-M05 NRP1 monoclonal antibody (M05), clone 1B3 ELISA,S-ELISA,WB-Ce,WB-Re H00000998-D01P CDC42 purified MaxPab rabbit polyclonal antibody (D01P) Det Ab,PLA-Ce,WB-Tr PAB10137 NTN1 polyclonal antibody WB,WB-Ce H00001020-M01A CDK5 monoclonal antibody (M01), clone 1A2 ELISA,WB-Re,WB-Ti H00022854-B02P NTNG1 purified MaxPab mouse polyclonal antibody (B02P) Det Ab,WB-Tr H00001020-B02P CDK5 purified MaxPab mouse polyclonal antibody (B02P) Det Ab,IF,WB-Ti,WB-Tr H00005058-M02 PAK1 monoclonal antibody (M02), clone 4D1 ELISA,IF,IHC-P,S-ELISA,WB-Ce,WB-Re H00001072-M04 CFL1 monoclonal antibody (M04), clone 1A1 ELISA,IF,IHC-P,S-ELISA,WB-Ce,WB-Re H00005062-M01 PAK2 monoclonal antibody (M01), clone 1E1 ELISA,PLA-Ce,WB-Re,WB-Ti H00001073-M03 CFL2 monoclonal antibody (M03), clone 6G9 ELISA,IF,IHC-P,S-ELISA,WB-Ce,WB-Re H00005063-M08 PAK3 monoclonal antibody (M08), clone 3A12 ELISA,IF,WB-Ce,WB-Re H00011261-M01 CHP monoclonal antibody (M01), clone 3G8 ELISA,WB-Re H00010298-M01 PAK4 monoclonal antibody (M01), clone 3F10 ELISA,S-ELISA,WB-Re H00006387-M01 CXCL12 monoclonal antibody (M01), clone 1E5 ELISA,S-ELISA PAB12890 PAK6 polyclonal antibody ICC,IHC,WB-Ce H00007852-M05 CXCR4 monoclonal antibody (M05), clone 2F1 ELISA,IHC-P,WB-Ce,WB-Re PAB2302 PAK7 polyclonal antibody ELISA,IHC-P,IP,WB-Tr H00001808-M01 DPYSL2 monoclonal antibody (M01), clone 1F11 ELISA,WB-Re PAB7879 PLXNA1 polyclonal antibody ELISA,ICC,IF,IP,WB-Ti H00056896-M02 DPYSL5 monoclonal antibody (M02), clone 2G4 ELISA,WB-Re,WB-Tr H00005362-M06 PLXNA2 monoclonal antibody (M06), clone 2G5 ELISA,WB-Ce,WB-Re H00001942-M01 EFNA1 monoclonal antibody (M01), clone 3C6 ELISA,S-ELISA,WB-Ti H00055558-A01 PLXNA3 polyclonal antibody (A01) ELISA H00001943-B01 EFNA2 MaxPab mouse polyclonal antibody (B01) Det Ab,WB-Tr H00023654-M07 PLXNB2 monoclonal antibody (M07), clone 2H3 ELISA H00001944-A01 EFNA3 polyclonal antibody (A01) ELISA,WB-Re H00010154-M06 PLXNC1 monoclonal antibody (M06), clone 1A12 ELISA,S-ELISA PAB11764 EFNA4 polyclonal antibody IHC-P H00005530-M03 PPP3CA monoclonal antibody (M03), clone 2G8 ELISA,IHC-P,WB-Re H00001946-M01 EFNA5 monoclonal antibody (M01), clone 1F12 ELISA,S-ELISA,WB-Ce,WB-Re H00005532-M01 PPP3CB monoclonal antibody (M01), clone 5D3 ELISA,RNAi-Ab,S-ELISA,WB-Re,WB-Tr PAB11124 EFNB1 polyclonal antibody WB PAB4153 PPP3CC polyclonal antibody ELISA,IHC-P,WB-Ce PAB5347 EFNB2 polyclonal antibody WB-Ce H00005534-M01 PPP3R1 monoclonal antibody (M01), clone 4E1 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