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CANINE FORMULA

VEGET A RIA N F O R M ULA

The Original Hydrolyzed Therapeutic Pet Food Purina® Pro Plan® Veterinary Diets HA Hydrolyzed® was the first truly hypoallergenic therapeutic pet food created with a single hydrolyzed source and a single carbohydrate source for the nutritional management of dogs with adverse food reaction.

Adverse food reaction can Include both skin and gastrointestinal signs.1 Hydrolyzed formulas are used for children with adverse food reactions to milk and soy.2 Our Nutritional Approach A 2006 evaluation of published studies on adverse food reaction showed the most common allergens in dogs are: beef, dairy, wheat, egg and chicken.1 Soy was less common.1 Even in soy allergic dogs, no antibody binding to hydrolyzed soy peptides under 20 kilodaltons has been detected.2 Additionally, soy hydrolysate did not elicit an allergic response in the majority of soy-allergic dogs.3,4,5 The average molecular weight of HA Hydrolyzed soy hydrolysate is approximately 13.7 kilodaltons. While food are relatively uncommon in the general canine population, intact corn and rice are listed as potential allergens in dogs.1 That’s why HA Hydrolyzed uses cornstarch as a highly refined carbohydrate source with less than one percent protein. A soy hydrolysate diet containing cornstarch did not elicit an allergic response in the majority of corn allergic dogs.4 Our unique formula contains 22-26% of fat as MCTs, a highly digestible fat source. Purina® Pro Plan® Veterinary Diets HA Hydrolyzed® Canine Formula was shown to improve clinical signs in dogs with previously refractory IBD.5

How We Compare Comparison of Therapeutic Hydrolyzed Canine Dry Diets *

Purina® Pro Plan® Royal Canin Royal Canin Royal Canin Veterinary Diets Hill's Prescription Veterinary Diet Veterinary Diet Veterinary Diet HA Hydrolyzed® Diet z/d Ultra Hydrolyzed Protein Hydrolyzed Protein Anallergenic/ Vegetarian Formula Adult HP Adult PS Ultamino

Hydrolyzed chicken Hydrolyzed soy Hydrolyzed poultry Primary Protein Sources Hydrolyzed liver, hydrolyzed Hydrolyzed soy protein, potato by-products soy protein isolate chicken protein protein aggregate

Protein (grams/100kcal) 5.32 4.8 5.2 5.63 4.67

Primary Corn starch Starch Brewers rice Dried potato Corn starch Carbohydrate Sources

Fat (grams/100kcal) 2.63 3.3 4.7 3.22 4.28

Life Stage Growth & Maintenance Maintenance Growth & Maintenance Maintenance Maintenance

*Based on ingredients and values published in Purina-2015 (average nutrient content), Royal Canin-2014 (typical analysis), and Hills-2014 (average nutrient content) Veterinary Product Guides

1 Verlinden et al. “ in Dogs and Cats: A Review”. Crit Reviews in Food Science and Nutrition (46). 2006. 259-273. 2 Serra, Montserrat et al. “Assessment of IgE binding to native and hydrolyzed soy protein in serum obtained from dogs with experimentally induced soy protein hypersensitivity”. AJVR (67). 2006. 1895-1899. 3 Serra, Montserrat et al “Immunologic responses against hydrolyzed soy protein in dogs with experimentally induced soy hypersensitivity”. AJVR (67). 2006. 484-488. 4 Jackson, H.A. “Evaluation of the clinical and allergen specific serum immunoglobulin E responses to oral challenge with cornstarch, corn, and a soy hydrolysate diet in dogs with spontaneous food allergy”. Vet Derm (14) 2003. 181-187. 5 Marks S. L., et al. “Dietary trial using a commercial hypoallergenic diet containing hydrolyzed protein for dogs with inflammatory bowel disease”. Vet Therapeutics (3). 2002. 109-118.

For questions, please contact your Purina Veterinary Consultant (PVC) or the Purina Veterinary Resource Center at 1-800-222-VETS (8387). ®

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CANINE FORMULA

VEGET A RIA N F O R M ULA

Indications: • Inflammatory bowel disease • Gastroenteritis associated • Pancreatitis with food allergy • History of urate urolithiasis • Lymphangiectasia • Protein losing enteropathy • Malabsorption • Elimination diet for food trials • Hyperlipidemia • Exocrine pancreatic insuciency • Hepatic encephalopathy • Dermatitis associated with food allergy

The Original Hydrolyzed Therapeutic Pet Food

Single hydrolyzed protein source

Single carbohydrate source

Highly digestible for optimal nutrient absorption

Also available: HA Hydrolyzed® Chicken Canine Formula and HA Hydrolyzed® Feline Formula.

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