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Agave Americana) See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/247825382 Agave (Agave americana) Article in Journal of Herbal Pharmacotherapy · November 2006 DOI: 10.1300/J157v06n02_09 CITATIONS READS 3 1,069 9 authors, including: John S Markowitz Catherine Ulbricht University of Florida 97 PUBLICATIONS 2,536 CITATIONS 190 PUBLICATIONS 6,688 CITATIONS SEE PROFILE SEE PROFILE Some of the authors of this publication are also working on these related projects: Pharmacogenetics View project Drug Metabolism and Pharmacokinetics View project All content following this page was uploaded by John S Markowitz on 22 May 2017. The user has requested enhancement of the downloaded file. Journal of Herbal Pharmacotherapy ISSN: 1522-8940 (Print) 1522-9106 (Online) Journal homepage: http://www.tandfonline.com/loi/iher20 Agave (Agave americana) Dana A. Hackman, Nicole Giese, John S. Markowitz, Adam McLean, Steven G. Ottariano, Chris Tonelli, Wendy Weissner, Shannon Welch & Catherine Ulbricht To cite this article: Dana A. Hackman, Nicole Giese, John S. Markowitz, Adam McLean, Steven G. Ottariano, Chris Tonelli, Wendy Weissner, Shannon Welch & Catherine Ulbricht (2006) Agave (Agave americana), Journal of Herbal Pharmacotherapy, 6:2, 101-122, DOI: 10.1080/ J157v06n02_09 To link to this article: http://dx.doi.org/10.1080/J157v06n02_09 Published online: 20 Aug 2009. Submit your article to this journal Article views: 60 View related articles Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=iher20 Download by: [University of Florida] Date: 22 May 2017, At: 11:43 NATURAL STANDARD REVIEW Catherine Ulbricht, PharmD, MBA(C), Column Editor Agave (Agave americana): An Evidence-Based Systematic Review by the Natural Standard Research Collaboration Dana A. Hackman, BS Nicole Giese, MS John S. Markowitz, PharmD Adam McLean, MPharm Steven G. Ottariano, RPh Chris Tonelli, MA Wendy Weissner, BA Shannon Welch, PharmD Catherine Ulbricht, PharmD for the Natural Standard Research Collaboration Dana A. Hackman is affiliated with Northeastern University. Nicole Giese is affiliated with Natural Standard Research Collaboration. John S. Markowitz is affiliated with University of South Carolina. Adam McLean is affiliated with University of Nottingham. Steven G. Ottariano is affiliated with VA Medical Center. Chris Tonelli is affiliated with Emmanuel College. Wendy Weissner is affiliated with Natural Standard Research Collaboration. Shannon Welch is affiliated with Northeastern University. Catherine Ulbricht is affiliated with Massachusetts General Hospital. Blinded Peer Review: Natural Standard Editorial Board. Natural Standard Review (www.naturalstandard.com) Copyright ©2005. Re- printed with permission. Journal of Herbal Pharmacotherapy, Vol. 6(2) 2006 Available online at http://jhp.haworthpress.com doi:10.1300/J157v06n02_09 101 102 JOURNAL OF HERBAL PHARMACOTHERAPY ABSTRACT. An evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, ad- verse effects, toxicology, and dosing. KEYWORDS. Folkloric precedent, history, pharmacology, toxicology, dosing, Agave, Agave americana SYSTEMATIC AGGREGATION, ANALYSIS, AND REVIEW OF THE LITERATURE Search Strategy To prepare each Natural Standard Review, electronic searches are conducted in nine databases, including AMED, CANCERLIT, CIN- AHL, CISCOM, the Cochrane Library, EMBASE, HerbMed, Interna- tional Pharmaceutical Abstracts, Medline, and NAPRALERT. Search terms include the common name(s), scientific name(s), and all listed synonyms for each topic. Hand searches are conducted of 20 additional journals (not indexed in common databases), and of bibliographies from 50 selected secondary references. No restrictions are placed on language or quality of publications. Researchers in the field of comple- mentary and alternative medicine (CAM) are consulted for access to ad- ditional references or ongoing research. Selection Criteria All literature is collected pertaining to efficacy in humans (regardless of study design, quality, or language), dosing, precautions, adverse ef- fects, use in pregnancy/lactation, interactions, alteration of laboratory Natural Standard Review 103 assays, and mechanism of action (in vitro, animal research, human data). Standardized inclusion/exclusion criteria are utilized for selection. Data Analysis Data extraction and analysis are performed by healthcare profession- als conducting clinical work and/or research at academic centers, using standardized instruments that pertain to each review section (defining inclusion/exclusion criteria and analytic techniques, including validat- ed measures of study quality). Data are verified by a second reviewer. Review Process Blinded review of reviews is conducted by multidisciplinary re- search-clinical faculty at major academic centers with expertise inepi- demiology and biostatistics, pharmacology, toxicology, complementary and alternative medicine (CAM) research, and clinical practice. In cases of editorial disagreement, a three-member panel of the Editorial Board addresses conflicts, and consults experts when applicable. Authors of studies are contacted when clarification is required. Update Process Natural Standard regularly monitors scientific literature and industry warnings. When clinically relevant new data emerge, best efforts are made to update content immediately. In addition, regular updates with renewed searches occur every 3-18 months, variable by topic. Synonyms/Common Names/Related Substances • Agavaceae, Agave abortiva, Agave abrupta, Agave acicularis, Agave acklinicola, Agave affinis, Agave ajoensis, Agave aktites, Agave albescens, Agave albomarginata, Agave angustiarum, Agave angustifolia, Agave angustissima, Agave anomala, Agave antillarum, Agave antillarum var. grammontensis, Agave applanata, Agave arizonica, Agave arubensis, Agave aspera, Agave asperrima, Agave attenuata, Agave aurea, Agave avellanidens, Agave bahamana, Agave bakeri, Agave banlan, Agave barbadensis, Agave baxteri, Agave bergeri, Agave bernhardi, Agave boldinghiana, Agave bollii, Agave botterii, Agave bouchei, Agave bourgaei, Agave bovicornuta, Agave braceana, Agave 104 JOURNAL OF HERBAL PHARMACOTHERAPY brachystachys, Agave bracteosa, Agave brandegeei, Agave brauniana, Agave breedlovei, Agave brevipetala, Agave breviscapa, Agave brevispina, Agave brittonia, Agave bromeliaefolia, Agave brunnea, Agave bulbifera, Agave cacozela, Agave cajalbanensis, Agave calderoni, Agave calodonta, Agave campanulata, Agave cantala, Agave capensis, Agave carchariodonta, Agave caribaea, Agave caribiicola, Agave carminis, Agave caroli-schmidtii, Agave celsii, Agave cernua, Agave cerulata, Agave chiapensis, Agave chihuahuana, Agave chinensis, Agave chisosensis, Agave chloracantha, Agave chrysantha, Agave chrysoglossa, Agave coccinea, Agave cocui, Agave coespitosa, Agave colimana, Agave collina, Agave colorata, Agave compacta, Agave complicata, Agave compluviata, Agave concinna, Agave congesta, Agave conjuncta, Agave connochaetodon, Agave consociata, Agave convallis, Agave corderoyi, Agave costaricana, Agave cucullata, Agave cundinamarcensis, Agave cupreata, Agave dasyliriodes, Agave datylio, Agave davilloni, Agave de-meesteriana, Agave dealbata, Agave deamiana, Agave debilis, Agave decaisneana, Agave decipiens, Agave delamateri, Agave densiflora, Agave dentiens, Agave deserti, Agave desmettiana, Agave diacantha, Agave difformis, Agave disceptata, Agave disjuncta, Agave dissimulans, Agave donnell-smithii, Agave durangensis, Agave dussiana, Agave eborispina, Agave eduardi, Agave eggersiana, Agave ehrenbergii, Agave eichlami, Agave ekmani, Agave elizae, Agave ellemeetiana, Agave endlichiana, Agave engelmanni, Agave entea, Agave erosa, Agave evadens, Agave excelsa, Agave expansa, Agave expatriata, Agave falcata, Agave felgeri, Agave felina, Agave fenzliana, Agave ferdinandi-regis, Agave filifera, Agave flaccida, Agave flaccifolia, Agave flavovirens, Agave flexispina, Agave fortiflora, Agave fourcroydes, Agave fragrantissima, Agave franceschiana, Agave franzosini, Agave friderici, Agave funifera, Agave funkiana, Agave galeottei, Agave garciae-mendozae, Agave geminiflora, Agave gentryi, Agave ghiesbrechtii, Agave glabra, Agave glaucescens, Agave goeppertiana, Agave glomeruliflora, Agave gracilipes, Agave gracilis, Agave grandibracteata, Agave granulosa, Agave grenadina, Agave grijalvensis, Agave grisea, Agave guadalajarana, Agave guatemalensis, Agave guedeneyri, Agave guiengola, Agave gutierreziana, Agave guttata, Agave gypsophila, Agave hanburii, Agave harrisii, Agave hartmani, Agave haseloffii, Natural Standard Review 105 Agave hauniensis, Agave havardiana, Agave haynaldi, Agave henriquesii, Agave hexapetala, Agave hiemiflora, Agave hookeri, Agave horizontalis, Agave horrida, Agave houghii, Agave huachucaensis, Agave huehueteca, Agave humboldtiana, Agave hurteri, Agave impressa, Agave inaequidens, Agave inaguensis, Agave indagatorum, Agave ingens, Agave inopinabilis, Agave integrifolia, Agave intermixta, Agave intrepida, Agave isthmensis, Agave jaiboli, Agave jarucoensis, Agave karatto, Agave kellermaniana, Agave kerchovei, Agave kewensis, Agave kirchneriana, Agave lagunae, Agave langlassei, Agave laticincta, Agave latifolia, Agave laurentiana, Agave laxa, Agave laxifolia, Agavelecheguilla, Agave lemairei, Agave lempana, Agave lespinassei, Agave
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