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The World's Best Software for Exact Distribution-Free Inference With StatXact Features StatXact uses unique, award- winning algorithms to create the largest collection of exact hypothesis tests, exact confidence intervals, and exact power and sample size calculations available anywhere. StatXact v6.0 with Cytel Studio™ StatXact offers more than 130 exact procedures covering the most frequently used statistical tests, confidence intervals and sample size requirements. The World’s Best Software for Exact Distribution-Free New in StatXact v6.0 Inference with Continuous or Categorical Data Among the 40 new features in StatXact v6.0 are: I Exact tests on unordered, singly ordered and doubly ordered RxC tables with stratification (exact Cochran- What is Special about StatXact? numerous other fields where experimental Mantel-Haenszel tests). See data are gathered and interpreted under Example 1 for an illustration. StatXact is the only software package in uncertainty. Any investigator whose I Exact tests for superiority, the world providing a complete set of studies are submitted to refereed journals equivalence and non-inferiority exact hypothesis tests, exact confidence or subject to regulatory review needs of paired binomial data. See intervals, and exact power or sample StatXact. Diverse groups ranging from Example 2 for an illustration. size calculations.There are over 130 biomedical scientists to expert witnesses I Exact confidence intervals procedures in StatXact, and all these testifying in lawsuits have found StatXact for differences of proportions procedures are exact, the gold standard indispensable to their work. and odds ratios of paired for statistical inference. Most other binomial data. See Example statistical packages rely on large-sample 2 for an illustration. Announcing Cytel Studio assumptions for their inferences: this I Exact interaction tests in can lead to incorrect conclusions if the While the core of StatXact is its large stratified 2xC contingency tables. data sets are not normally distributed. collection of exact procedures, it is often I Exact power and sample size StatXact utilizes powerful numerical necessary to perform more routine for comparing two binomials by Barnard’s unconditional algorithms that make exact inferences statistical tasks such as summarizing and by permuting the data that were actually exact test. (More powerful plotting data, transforming variables, and than Fisher’s exact test.) observed, thus eliminating the need to importing and exporting data in diverse I make distributional assumptions.With Additional exact power and file formats. For SAS® users, Cytel provides sample size procedures for StatXact data sets can be small or large, StatXact PROCS, a version of StatXact comparing two ordered balanced or unbalanced, sparse or that is fully integrated into the SAS multinomials. dense, or in the form of contingency system. For non-SAS users, Cytel is now I Additional exact power and tables with small and zero cell counts. introducing Cytel Studio as an integral sample size procedures for The end-user is shielded from all these part of StatXact v6.0. Cytel Studio offers comparing K ordered binomials. complex calculations by a simple, basic statistics, t-tests, ANOVA, multiple I Cytel Studio: Summary intuitive calculator-like user interface. linear regression, histograms, scatterplots, statistics, t-tests, ANOVA and bubbleplots, routine data manipulation linear regression, plotting Who Needs StatXact? capabilities and a script language for routines, expanded Case and Table editors, and a new performing repetitive statistical tasks in workspace organizer to handle StatXact is widely used by researchers a batch environment. in biostatistics, epidemiology, psychiatry, multiple datasets. Expanded import/export capabilities. sociology, environmental science, and See reverse for a complete list of features. The following examples demonstrate exact tests for stratified R x C tables and exact Examples confidence intervals for the difference of two related binomial proportions.You won’t find these features in any other statistical software, including previous versions of StatXact. EXAMPLE 1: Is Job Satisfaction Related to Income? Respondents to the General Social Survey This information is easily entered in the Cochran-Mantel-Haenszel test for rated their level of satisfaction on the job. StatXact in table form as shown. stratified doubly-ordered RxC data. The following p-values were returned. The following tables show the number of In previous versions of StatXact, analysis people at each satisfaction level, by gender of stratified RxC tables was not possible, Exact p-value: .058 and income level (in thousands of dollars) so one would have to ignore the gender Asymptotic p-value: .041 for a subset of the survey population. of the individuals and combine the two tables into one. An analysis of While the asymptotic result suggests the resulting combined doubly significance, this value is questionable ordered RxC table using the because of the number of null and low Linear by Linear test in StatXact values in the cells of the tables. Only an v5.0 gives the following results: exact analysis is correct, and shows that the results fall short of statistical Exact p-value: .049 significance – once gender is accounted Asymptotic p-value: .034 for, there is not a significant relationship between job satisfaction and income However, combining the two level. Only StatXact v6.0 offers this exact tables prior to the analysis is test, without which one would incorrectly inappropriate since gender is Source: Data are from General Social Survey, assume that a significant relationship National Opinion Research Center, 1991; as cited in an important covariate.Thus the analysis exists between job satisfaction and income. Agresti, A., Categorical Data Analysis, p. 287 (Wiley, was performed again in StatXact v6.0, 2002). A subset of the data is used and one cell altered for illustrative purposes. this time using the stratified data and EXAMPLE 2: Difference of Two Related Binomial Proportions Miyanaga (Japanese Journal of Soft thermal system, we wish to Contact Lenses, 1994) conducted a cross- determine if these data over clinical trial comparing a chemical provide convincing evidence disinfectant system (hydrogen peroxide) of non-inferiority for the with a thermal disinfectant system for soft chemical system.The claim of contact lenses.The effectiveness of each non-inferiority can be justified system was tested in a random order on if it can be demonstrated, at 44 subjects. Excellent results were the 5% level of significance, obtained.The thermal system was that the true response rate effective on 44/44 subjects (100% with the chemical response rate) , while the chemical system disinfectant is at most 0.1 lower than 1. Exact Confidence Interval:We can was effective on 43/44 subjects (97.7% the true response rate with the thermal compute a 95% exact upper confidence response rate). Since the chemical system disinfectant.There are two ways to solve bound for the difference between the is simpler and cheaper to adopt than the this problem in StatXact v6.0. thermal response rate and the chemical Are you a SAS User? StatXact v6.0 What Reviewers Say PROCs for SAS Users "With your software, I have a level of functionality in analysis of small data sets which was unheard of a few years ago. In fact, before the advent of your If you perform all of your analysis using censored survival data, and cannot software, my predecessor wrote SAS software, it may not be practical for calculate exact power and sample size. extremely complex basic programs to perform those you to switch to a different package for StatXact PROCs offers over 51 new tests calculations. It does everything exact procedures. But SAS software Version in these categories alone.The table on I have needed to do." 9 offers only a limited number of exact the next page details what exact tests Graeme Tucker Head and categorical analysis features. For this and confidence intervals SAS software Health Statistics Unit Department reason, Cytel has created StatXact v6.0 Version 9 and StatXact PROCs offer. of Human Services, Government of South Australia PROCs for SAS Users, a set of over ten PROCs that deliver all of the power of Create Reports and Run “StatXact has two superior StatXact within the SAS environment. Batch Files Faster characteristics. One is the ease These exact PROCs are only available of use – StatXact is extremely easy StatXact PROCs are completely integrated, from Cytel Software. to use and understand, which is so that SAS users never have to switch a real draw.The second is that between programs to call exact tests. All SAS System Plus StatXact PROCs: it's not only accurate, but it's An Unbeatable Pair the procedures can be called through a accurate and effective even for batch file and documented for regulatory small sample size, which makes Adding StatXact PROCs to the SAS system submission. Moreover, StatXact PROCs it stand out from other statistical more than doubles the number of exact features an “automatic pilot”function packages, none of which have tests and confidence intervals you will that automatically distinguishes large as many options for exact tests. have available to you. For instance, SAS data sets from small data sets, applies It's a terrific product.” software Version 9 offers no exact tests the appropriate exact test, and keeps William Fals-Stewart for stratified data, K related samples, or your batch job running smoothly. Senior Research Scientist, Research Institute on Addictions University at Buffalo,The State University of New York "For my purposes, StatXact is state of the art.There are some cases where we can't live without it." response rate and verify that the upper computed by treating the response rates Paul Gibbs bound is less than 0.1. as though they had arisen from two Statistician independent binomials, we would obtain 2. Exact Test of Non-Inferiority: An an upper confidence bound of 0.1033 “I have found that Cytel Software alternative approach is to perform an and a corresponding exact p-value of Corp has consistently produced exact test of non-inferiority using 0.1 0.0571.This result does not demonstrate the best statistical software on the as the non-inferiority margin.
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