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Thursday, August3, 2017 • APG News B7 ECBC Frompage B1 narcotic usage and the defense communi- ties. Feasel has proposed studies at ECBC to research such effects of removing the drug from cell receptors using substances such as naloxone. “Higher potency versions of naloxone are available, however the Food and Drug Administration has not seen a need to get them approved for human use, until now. These ultra-potent opioid exposures are not only a chemical defense issue, but they are also a public health issue,” Feasel reported. Feasel, who recently received a Ph.D. in toxicology at the University of Maryland, Baltimore School of Medicine, ap- proached principal investigator Marilyn A. Huestis, Ph.D., then-chief of chemistry and drug metabolism at the National Institute on Drug Abuse’s (NIDA) Intra- mural Research Program about a collabo- ration on identifying carfentanil metabo- lites. Huestis recognized the epidemic and need to research carfentanil, and agreed to collaborate with Feasel and Robert Kris- tovich, Ph.D., ECBC Molecular Toxicology branch chief. Feasel worked in NIDA’s labs for weeks incubating hepatocytes, commonly re- ferred to as human liver cells, in a two-dimensional (2D) platform. Twelve metabolites were identified in total and the hepatocyte incubations showed slower clearance, providing some insight into the duration of carfentanil’s effects on U.S. ARMY PHOTO the human body. Recent biological studies Dr. Mike Feasel (right) and Acting Edgewood Chemical Biological Center Director Dr. Eric Moore discuss effects of carfentanil exposure have shown cells forming on their own and its relation to warfighters. adhere to each other forming spheroids. Feasel conducted a follow-on study incu- subculture we are enabling the access to As carfentanil continues to make head- the process and techniques of generating bating carfentanil with three dimensional realistic data or in vivo metabolism,” lines the research being done at ECBC is metabolite libraries to ECBC” remarked (3D) liver spheroids. In this instance the observed Feasel. vital as more information is brought to Feasel. “ECBC could apply the technique spheroids closely resembled a human liver Conclusions on this study have not yet light about the substance. to unknown compounds which may be of organ versus the 2D platform which was been made as Feasel and his team are in “My goal with this study was to not only interest to the CB defense community.” similar to an individual cell. “By using a 3D the process of analyzing the data. to understand this opioid, but to also bring

substance misuse,” said Maj. Donell Bar- “Behavioral health allows Soldiers to These recommendations could lead to nett, BSHOP chief of Field Investigations work on issues and get the assistance they changes in policies and procedures. HEALTH and Program Evaluation. Barnett also deserve,” Barnett said. “I think it’s a good For more information on the APHC’s Frompage B1 explained the importance of focus groups, thing for Soldiers and readiness, and it BSHOP Program, contact: administrative data systems analysis. The saying they can help provide the story to allows them to focus better on the Army Public Health Center, http:// purpose of the survey and administrative explain the numbers, allowing the team to mission.” phc.amedd.army.mil data analysis was to identify the who, what be better informed and able to intervene if The BSHOP team is part of the APHC’s Military Crisis Hotline, 1-800-273- and when of the problem, while the focus there is a problem. Clinical Public Health and Epidemiology TALK (8255) group aimed to identify the why and how The survey covered topics such as Directorate and is made up of public Military One Source , 1-800-342-9647 of the problem. demographics, social support and person- health and behavioral health profession- The Defense Center of Excellence, “The surveys really help you get a sense al experiences. The focus group discussed als. After identifying the problems, 1-866-966-1020 of trends of issues, whether (or not group dynamics, living and social environ- BSHOP will make suggestions to Army they’re) trends in behavioral health and ments, and the Soldier’s basic week. commanders to help them solve problems. DID YOU KNOW?

The son of President Dwight Eisenhower rose to the rank of brigadier general, served in the administration of President Richard Nixon and as U.S. Ambassador to Belgium. Born Aug. 3, 1922, John Sheldon Doud Eisenhower was the second child of Dwight D. Eisenhower and his wife, Mamie. Their oldest child, ason named Doud, died of scarlet fever at age 3. John Eisenhower served in the Army like his father and was a cadet at West Point, graduating June 6, 1944, the day of the Normandy landing. Eisenhower served during World War II and the Korean War, and then left active duty in 1963 to serve in the Army Reserve until his retirement in 1975. Though he attained the rank of brigadier general and earned several awards and decorations, Eisenhower felt his career was thwarted by concerns for his safety. He felt leaders did not want his death or capture to distract his father, who was the Supreme Allied commander.

He protested profusely, when while serving in Korea COURTESY PHOTO COURTESY PHOTO as a major in 1952, he was reassigned from a This photo of John Eisenhower was taken during a 1990 Johns Eisenhower’s son, David, at age 12, poses at the combat unit to a desk job while his father ran for tour of the nulear-powered aircraft carrier USS Dwight D. presidential retreat in Western Maryland that was named President and he shared his feelings in a 2008 Eisenhower (CVN 69), which was named for his father, the for him and his great-grandfather by his grandfather, Presi- “New Yo rk Times” opinion piece titled, “Presidential former president. dent Dwight D. Eisenhower. Children Don’t Belong in Battle.” During his father’s presidency, John Eisenhower Committee in 1972 and in 1975 he served President after 39 years together. In 1988, Eisenhower served as Assistant Staff Secretary in the White Gerald Ford as chairman of the President’s married Joanne Thompson. They lived in Trappe, House, on the Army’s General Staff, and in the Advisory Committee on Refugees. Maryland, where he died Dec. 21, 2013. He is buried White House as assistant to NATO Supreme Allied Eisenhower and his wife, the former Barbara on the grounds of the U.S. Military Academy at Commander Gen. Andrew Goodpaster. Jean Thompson, had four children: West Point. From the death of John Coolidge in He later served in the administration of President Dwight David Eisenhower II, born 1948, a 2000 until his own death, Eisenhower was the Richard Nixon, who was his father’s Vice President, presidential grandson who married Julie Nixon, oldest presidential child. and as the 45th U.S. Ambassador to Belgium. In herself a presidential daughter; (Barbara) Anne Eisenhower was the author of several books, addition, President Nixon appointed Eisenhower Eisenhower born 1949; Susan Elaine Eisenhower which included “The Bitter Woods,” a study of the Chairman of the Interagency Classification Review born 1951; and Mary Jean Eisenhower, born 1955. Battle of the Bulge, and “So Far from God,” a history John Eisenhower and his wife divorced in 1986 of the U.S.-Mexican War.

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