Prepared: January 5, 2011

BRIAN O’NEAL BACHMANN, PH.D. Departments of Chemistry and Biochemistry Vanderbilt University Nashville, TN 37235-1822 Phone: (615) 322-8865; Fax: (615) 343-1234 E-mail: [email protected] http://www.vanderbilt.edu/AnS/Chemistry/BachmannGroup/

DEGREES EARNED

1995 – 2000 The Johns Hopkins University, Baltimore, Maryland. Ph.D. degree in Chemistry, December, 2000. Dissertation entitled: Identification and Characterization of β−Lactam Synthetase of Clavulanic Acid Biosynthesis. Advisor: Professor Craig. A. Townsend 1993 – 1994 Southern Methodist University, Dallas, Texas. M.S. degree in Chemistry, December 1994. Thesis entitled: Synthesis and Evaluation of Mechanism Based β−lactamase Inhibitors. Advisor: Professor John D. Buynak 1988 – 1992 Virginia Tech, Blacksburg, Virginia. B.S. degree in Chemistry, December 1992. Undergraduate Research Advisor: Tomas Hudlicky

EMPLOYMENT HISTORY

2000 – 2001 Postdoctoral Fellow, The Johns Hopkins University Department of Chemistry, Baltimore, Maryland 2001 – 2002 Assistant Director of Chemistry, Ecopia Biosciences (now Thallion Pharmaceuticals), Montreal, Quebec, Canada 2002 – 2003 Director of Chemistry, Ecopia Biosciences (now Thallion Pharmaceuticals), Montreal, Quebec, Canada 2003 – current Assistant Professor of Chemistry, Vanderbilt University Department of Chemistry, Nashville, Tennessee 2000 – current Director, Board of Directors, Dymax Corporation, Torrington, Connecticut

HONORS AND AWARDS

• American Society of Chemists: Outstanding Graduate Student in Chemistry, 1994 • Commercial Development Award – Dymax Corporation, 1995 • Sonneborn Graduate Fellowship, 1997 – 1999 • Alexander Kossiakoff Graduate Student, 2000 • Sarah and Adolph Roseman Achievement Award in for Outstanding Accomplishment in Chemistry, 2000 • Petroleum Research Fund type G award, 2004

1

• RO1 ‘model proposal’ at NIH workshop for new investigators, 2010 PROFESSIONAL SOCIETIES AND ACTIVITIES

• American Chemical Society (member) 1995 - present • Society for Industrial Microbiology (member) 2000 - present • American Society of Microbiology (member) 2010 - present • National Association of Corporate Directors (member) 2001- present • Reviewer for Nature Chemical Biology, Proceedings of the National Academy of Sciences, Journal of the American Chemical Society, Chemistry & Biology, Journal of Biological Chemistry and Applied Environmental Microbiology among others • Reviewer for the Petroleum Research Fun Type G- Grant award, 2004 • Study Section Member for Program Project Award, National Inst. Health, 2005 • Study Section Member (Ad Hoc) for SBC-B, Nat. Inst. Health 2006, 2010 • Session Convener, Society for Industrial Microbiology Annual Meeting, 2006

RESEARCH

Published Articles (Corresponding author underlined)

Independent Work

1. Panosian, T. D., Nannemann, D. P., Watkins, G., Phelan, V. V., McDonald, W. H., Wadzinski, B. E., Bachmann, B. O. and Iverson, T. M., The Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle. Journal of Biological Chemistry. 2010, . (in press) Pubmed. DOI.

2. Vey, J. L., Al-Mestarihi, A., Hu, Y., Funk, M. A., Bachmann, B. O. and Iverson, T. M., Structure and mechanism of ORF36, an amino sugar oxidizing enzyme in everninomicin biosynthesis. Biochemistry. 2010, 49, 9306-17.Pubmed. DOI.

3. Akif, M., Ntai, I., Sturrock, E. D., Isaac, R. E., Bachmann, B. O. and Acharya, K. R., Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster. Biochemical and biophysical research communications. 2010, . (in press). Pubmed. DOI.

4. Bachmann, B. O., McNees, R., Melancon, B. J., Ghidu, V. P., Clark, R., Crews, B. C., Deguire, S. M., Marnett, L. J. and Sulikowski, G. A., Light-induced isomerization of apoptolidin A leads to inversion of C2-C3 double bond geometry. Organic Letters. 2010, 12, 2944-2947. Pubmed. DOI.

2

5. Panosian, T. D., Nannemann, D. P., Bachmann, B. O. and Iverson, T. M., Crystallization and preliminary X-ray analysis of a phosphopentomutase from Bacillus cereus. Acta Crystallographica F. 2010, 66, 811-814. Pubmed. DOI.

6. Du, Y., Gisselberg, J. E., Johnson, J. D., Lee, P. J., Prigge, S. T. and Bachmann, B. O., Lactococcus lactis fabH, encoding β−ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener. Applied and Environmental Microbiology. 2010, 76, 3959-3966. Pubmed. DOI.

7. Nannemann, D. P., Kaufmann, K. W., Meiler, J. and Bachmann, B. O., Design and directed evolution of a dideoxy purine nucleoside phosphorylase. Protein Engineering Design and Selection. 2010, 23, 607-616. Pubmed. DOI.

8. Reniere, M. L., Ukpabi, G. N., Harry, S. R., Stec, D. F., Krull, R., Wright, D. W., Bachmann, B. O., Murphy, M. E. and Skaar, E. P., The IsdG-family of haem oxygenases degrades haem to a novel chromophore. Molecular Microbiology. 2010, 75, 1529-1538. Pubmed. DOI.

9. Bachmann, B. O., Biosynthesis: is it time to go retro? (commentary). Nature Chemical Biology. 2010, 6, 390-393. Pubmed. DOI.

10. Carter, M. D., Phelan, V. V., Sandlin, R. D., Bachmann, B. O. and Wright, D. W., Lipophilic mediated assays for β−hematin inhibitors. Combinatorial Chemistry & High Throughput Screening. 2010, 13, 285-292. Pubmed.

11. Scism, R. A. and Bachmann, B. O., Five-component cascade synthesis of nucleotide analogues in an engineered self-immobilized enzyme aggregate. Chembiochem. 2010, 11, 67-70. Pubmed. DOI.

12. Phelan, V. V., Du, Y., McLean, J. A. and Bachmann, B. O., Adenylation enzyme 18 characterization using γ − O4-ATP pyrophosphate exchange. Chemistry & Biology. 2009, 16, 473-478. Pubmed. DOI.

13. Ghidu, V. P., Ntai, I., Wang, J., Jacobs, A. T., Marnett, L. J., Bachmann, B. O. and Sulikowski, G. A., Combined chemical and biosynthetic route to access a new apoptolidin congener. Organic Letters. 2009, 11, 3032-3034. Pubmed. DOI.

14. Ntai, I. and Bachmann, B. O., Identification of ACE pharmacophore in the phosphonopeptide metabolite K-26. Bioorganic & Medicinal Chemistry Letters. 2008, 18, 3068-3071. Pubmed. DOI.

15. Hu, Y., Phelan, V. V., Farnet, C. M., Zazopoulos, E. and Bachmann, B. O., Reassembly of anthramycin biosynthetic gene cluster by using recombinogenic cassettes. Chembiochem. 2008, 9, 1603-1608. Pubmed. DOI.

16. Hu, Y., Al-Mestarihi, A., Grimes, C. L., Kahne, D. and Bachmann, B. O., A unifying nitrososynthase involved in nitrosugar biosynthesis. Journal of the American Chemical Society. 2008, 130, 15756-15757. Pubmed. DOI.

3

17. Scism, R. A., Stec, D. F. and Bachmann, B. O., Synthesis of nucleotide analogues by a promiscuous phosphoribosyltransferase. Organic Letters. 2007, 9, 4179-4182. Pubmed. DOI.

18. Hu, Y., Phelan, V., Ntai, I., Farnet, C. M., Zazopoulos, E. and Bachmann, B. O., Benzodiazepine biosynthesis in Streptomyces refuineus. Chemistry and Biology. 2007, 14, 691- 701. Pubmed. DOI.

19. Bachmann, B. O., Foundations for directed alkaloid biosynthesis (commentary). Chemistry and Biology. 2007, 14, 875-876. Pubmed. DOI.

20. Wilkinson, B. and Bachmann, B. O., Biocatalysis in pharmaceutical preparation and alteration. Current Opinion in Chemical Biology. 2006, 10, 169-176. Pubmed. DOI.

21. Sulikowski, M. M. and Bachmann, B. O., Designing a curriculum that goes beyond a list of topics (commentary). ACS Chemical Biology. 2006, 1, 489-491. Pubmed. DOI.

22. Ntai, I., Phelan, V. V. and Bachmann, B. O., Phosphonopeptide K-26 biosynthetic intermediates in Astrosporangium hypotensionis. Chemical Communications. 2006, 4518-4520. Pubmed. DOI.

23. Ntai, I., Manier, M. L., Hachey, D. L. and Bachmann, B. O., Biosynthetic origins of C-P bond containing tripeptide K-26. Organic Letters. 2005, 7, 2763-2765. Pubmed. DOI.

24. Bachmann, B. O., Decoding chemical structures from genomes (commentary). Nature Chemical Biology. 2005, 1, 244-245. (Commentary). Pubmed. DOI.

Book Chapters

25. Bachmann, B. O. and Ravel, J., Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data. Methods in enzymology. 2009, 458, 181-217. Pubmed. DOI.

Submitted Articles (review pending 2010)

26. Timothy D. Panosian, David P. Nannemann, Guy Watkins, Brian Wadzinski, Brian O. Bachmann, Tina M. Iverson. Turnover of Bacillus cereus phosphopentomutase is primed by phosphorylation of Thr-85 and triggered by ribose-5-phosphate binding Journal of Biological Chemistry, submitted June 2010.

27. Jessica L. Vey, Ahmad Al-Mestarihi, Yunfeng Hu, Michael A. Funk, Brian O. Bachmann, and T. M. Iverson. Mechanism of amino sugar oxidation during everninomycin biosynthesis. Journal of the American Chemical Society, submitted June 2010.

4

28. Larissa Spell Fen, Cody Goodwin, Brian O. Bachman and John McLean. Ion mobility mass spectrometry for peptide natural product discovery. Journal of the American Chemical Society

2003, and prior to Vanderbilt

29. McAlpine, J. B., Bachmann, B. O., Piraee, M., Tremblay, S., Alarco, A. M., Zazopoulos, E. and Farnet, C. M., Microbial Genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example. Journal of Natural Products. 2005, 68, 493-496. DOI.

30. Zazopoulos, E., Huang, K. X., Staffa, A., Liu, W., Bachmann, B. O., Nonaka, K., Ahlert, J., Thorson, J. S., Shen, B. and Farnet, C. M., A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nature Biotechnology. 2003, 21, 187-190. DOI.

31. Miller, M. T., Bachmann, B. O., Townsend, C. A. and Rosenzweig, A. C., The catalytic cycle of β-lactam synthetase observed by X-ray crystallographic snapshots. Proceedings of the National Academy of Sciences of the United States of America. 2002, 99, 14752-14757. DOI.

32. Ahlert, J., Shepard, E., Lomovskaya, N., Zazopoulos, E., Staffa, A., Bachmann, B. O., Huang, K. X., Fonstein, L., Czisny, A., Whitwam, R. E., Farnet, C. M. and Thorson, J. S., The calicheamicin gene cluster and its iterative type I enediyne PKS. Science. 2002, 297, 1173- 1176. DOI.

33. Zhou, J., Kelly, W. L., Bachmann, B. O., Gunsior, M., Townsend, C. A. and Solomon, E. I., Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional α-KG-dependent non-heme iron enzyme: Correlation with mechanisms and reactivities. Journal of the American Chemical Society. 2001, 123, 7388-7398. DOI.

34. Miller, M. T., Bachmann, B. O., Townsend, C. A. and Rosenzweig, A. C., Structure of β- lactam synthetase reveals how to synthesize antibiotics instead of asparagine. Nature Structural Biology. 2001, 8, 684-689. DOI.

35. Bachmann, B. O. and Townsend, C. A., Kinetic mechanism of the β-lactam synthetase of Streptomyces clavuligerus. Biochemistry. 2000, 39, 11187-11193. DOI.

36. Zhou, J., Gunsior, M., Bachmann, B. O., Townsend, C. A. and Solomon, E. I., Substrate binding to the α-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: Coupling mechanism of oxidative decarboxylation and hydroxylation. Journal of the American Chemical Society. 1998, 120, 13539-13540. DOI.

37. Bachmann, B. O., Li, R. F. and Townsend, C. A., β-Lactam synthetase: A new biosynthetic enzyme. Proceedings of the National Academy of Sciences of the United States of America. 1998, 95, 9082-9086. DOI.

5

38. Buynak, J. D., Rao, A. S., Ford, G. P., Carver, C., Adam, G., Geng, B., Bachmann, B., Shobassy, S. and Lackey, S., 7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase. Journal of Medicinal Chemistry. 1997, 40, 3423-3433. DOI.

39. Buynak, J. D., Wu, K. C., Bachmann, B., Khasnis, D., Hua, L., Nguyen, H. K. and Carver, C. L., Synthesis and biological-activity of 7-alkylidenecephems. Journal of Medicinal Chemistry. 1995, 38, 1022-1034. DOI.

40. Buynak, J. D., Geng, B., Bachmann, B. and Hua, L., The synthesis and β-lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporins. Bioorganic & Medicinal Chemistry Letters. 1995, 5, 1513-1518. DOI.

41. Hudlicky, T., Mandel, M., Rouden, J., Lee, R. S., Bachmann, B., Dudding, T., Yost, K. J. and Merola, J. S., Microbial oxidation of aromatics in enantiocontrolled synthesis 1. Expedient and general asymmetric-synthesis of inositols and carbohydrates via an unusual oxidation of a polarized diene with potassium-permanganate. Journal of the Chemical Society-Perkin Transactions 1. 1994, 1553-1567. DOI.

42. Buynak, J. D., Khasnis, D., Bachmann, B., Wu, K. C. and Lamb, G., Synthesis and mechanistic evaluation of 7-vinylidenecephem sulfones as β-lactamase inhibitors. Journal of the American Chemical Society. 1994, 116, 10955-10965. DOI.

Working papers

1. Kasia Derewacz, Cynthia R. McNees, John Hickman, Larry Marnett, Prasad Polavarapu and Brian O. Bachmann: Hypogeamycin a new S-bridged dimeric pyronapthoquinone from a cave derived actinomycete. Journal of Natural Products.

2. Jerry Jenkins, David Wright and Brian O. Bachmann. Natural extract lead identification software for automation of bioeffector discovery from complex extracts. BMC Bioinformatics.

3. David Nannemann, William Birmingham, Robert A. Scism and Brian O. Bachmann. Assessing directed evolution for the generation of new biosynthetic enzymes. Future Medicinal Chemistry.

4. Robert A Scism and Brian O. Bachmann. Survival of the least-fit assay for directed evolution. Nature Chemical Biology.

Patents

2003 and prior to Vanderbilt

6

1. Bachmann, Brian O.; McAlpine, James B.; Zazopoulos, Emmanuel; Farnet, Chris M. Polyene polyketides, processes for their production and their use as pharmaceuticals. PCT Int. Appl. (2004), CODEN: PIXXD2 WO 2004101502 A1 20041125 AN 2004:1015999

2. Bachmann, Brian O.; Mcalpine, James B.; Zazopoulos, Emmanuel; Farnet, Chris M.; Piraee, Mahmood. Farnesyl dibenzodiazepinones, their production with microorganisms, and their use as antitumor, antibacterial, and antiinflammatory agents. PCT Int. Appl. (2004), 269 pp. WO 2004065591 A1 20040805 CAN 141:167757 AN 2004:634064

3. Bachmann, Brian O.; Mcalpine, James B.; Zazopoulos, Emmanuel; Farnet, Chris M. Polyene polyketides, processes for their production using polyketide synthetase genes and enzymes from Streptomyces aizunensis, and their use as fungicidal and antitumor pharmaceutical. PCT Int. Appl. (2004), 554 pp. WO 2004065401 A1 20040805 CAN 141:167732 AN 2004:633940

4. Farnet, Chris M.; McAlpine, James B.; Bachmann, Brian O.; Zazopoulos, Emmanuel; Staffa, Alfredo; Zhao, Zhizi; Wong, Sai Man; Desjardins, Nicolas. Method, system and knowledge repository for identifying a secondary metabolite from a microorganism. PCT Int. Appl. (2003), 96 pp. WO 2003062458 A2 20030731 CAN 139:114135 AN 2003:591366

5. Stephen Cantor, Brian Bachmann. Solvent Free Ultraviolet light Polymerizable Coating US- 05712321

6. John Buynak, Brian Bachmann. 7-Vinylidene Cephalosporins as β−Lactamase Inhbitors, US- 94354858-941209

7. John Buynak, Brian Bachmann. 7-Alkylidinecephalosporanic Acid Derivatives as β−Lactamase Inhibitors, US-94-354850-941209

Articles in Conference Proceedings

1. Bachmann, Brian O.; Hu, Yunfeng; Al-Mestarihi, Ahmad; Nanneman, David; Robert, Scism. Deconstruction and construction of biosynthetic pathways. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 (2010)

2. Ntai, Ioanna; Phelan, Vanessa V.; Du, Yu; Bachmann, B. O. Progress toward isolating the biosynthetic gene cluster of phosphonopeptide K-26. Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007 (2007)

3. Ntai, Ioanna; Hachey, David L.; Manier, M. Lisa; Bachmann, B.O. Studies on the Biosynthesis of C-P Bond Containing Natural Product K-26. Abstracts, 57th Southeast/61st Southwest Joint Regional Meeting of the American Chemical Society, Memphis, TN, United States, November 1-4 (2005)

7

4. Scism, Robert A.; Bachmann, B. O. Directed Evolution of Azole Nucleotide Biosynthesis. Abstracts, 57th Southeast/61st Southwest Joint Regional Meeting of the American Chemical Society, Memphis, TN, United States, November 1-4 (2005)

5. Zhou, Jing; Gunsior, Michelle; Bachmann, B. O.; Kelly, Wendy L.; Pavel, Elizabeth G.; Townsend, Craig A.; Solomon, Edward I. Circular dichroism and magnetic circular dichroism spectroscopic studies of the mononuclear nonheme iron enzyme clavaminate synthase 2: Correlation to mechanism and function. Book of Abstracts, 219th ACS National Meeting, San Francisco, CA, March 26-30, 2000 (2000)

RESEARCH GRANTS RECEIVED

Active

Title: Antisense attenuation of biosynthetic genes in actinomycetes. Role: PI: B. O. Bachmann Source: NIH/NIEHS Vanderbilt Center in Molecular Toxicology pilot project NIH P30 ES000267 Funding Period: 04/01/04 – 04/31/05 Total Costs: $60,000

Title: Biosynthesis of hypotensive phosphonopeptide natural products. Role: PI: B. O. Bachmann Source: NIH/NIGMS 1R01GM077189-01 Funding Period: 04/01/06 – 03/31/11 Total Costs: $1,109,727

Title: Green biosynthesis of energetic intermediates: Tertiary alkyl nitro compounds Role: PI: B. O. Bachmann Source: Office of Naval Research N00014-09-1-012 Funding Period: 01/01/09 – 12/31/11 Total Costs: $314,609

Title: Phase II STTR: A high throughput screening approach enabling sustainable discovery of novel lead compounds from natural product extracts Role: PI: J. Jenkins (CFD Research Corp). Vanderbilt subcontracting co-investigators D. W. Wright and B. O. Bachmann Source: ARMY Research Office W81XWH-07-C-0092 Funding Period: 09/01/08 – 08/31/10 Total Costs: $243,616 (Bachmann ~ $157,172)

Title: New methodologies for accelerating natural product discovery Role: Co-PIs B.O. Bachmann (corresponding) and John McLean

8

Source: NIH/NIGMS 1R01GM092218-01 Funding Period: 08/01/10 – 07/31/13 Total Costs: $1,116,523 (Bachmann ~ $745,000)

Inactive

Title: Carbon-phosphorus bond containing natural peptides Role: PI: B. O. Bachmann Source: ACS- Petroleum Research Fund Type G Funding Period: 09/01/05 – 08/31/07 Total Costs: $53,000

Title: Green biosynthesis of energetic intermediates: Tertiary alkyl nitro compounds Role: PI: B. O. Bachmann Source: Office of Naval Research Funding Period: 01/01/05 – 2/31/08 Total Costs: $349,471

Title: Instrumentation: A 'secondary metabolomics' platform for bioprobe and drug discovery Role: PI: B. O. Bachmann Source: Office of Naval Research N000140910854 Funding Period: 04/15/09-04/15/2010 Total Costs: $279,875

Title: Phase I STTR: A high throughput screening approach enabling sustainable discovery of novel lead compounds from natural product extracts Role: PI: J. Jenkins (CFD Research Corp). Vanderbilt subcontracting co-investigators D. W. Wright and B. O. Bachmann Source: ARMY Research Office W81XWH-07-C-0092 Funding Period: 07/2007 – 12/2008 Total Costs: $21,288

Pending Review

Title: Producing synthetic antivirals using engineered microbes Role: PI: B.O. Bachmann Source: Bill and Melinda Gates Foundation Grand Challenges 2010 Funding Period: 1/01/2009 – 12/29/2010 Total Costs: $100,000

9

INVITED PRESENTATIONS

Sponsored presentations Diversa Corperation November 2004, San Diego, California, Nov. 2004. Wake Forest University, Winston Salem, North Carolina, Mar. 2006. Green Synthesis Program Review at ONR, Alexandria, Virginia, Sept. 2006. University of Texas Southwestern Medical Center, Dallas, Texas, Apr. 2006. Southern Methodist University, Dallas, Texas, Apr. 2006. Society of Industrial Microbiology, Convener Session 26: New Technologies and Systems in Biocatalysis and speaker, Baltimore, Maryland, Aug. 2006. Transatlantic Frontiers of Chemistry, Durham, New Hampshire, Aug. 2006. Wichita State University, Wichita, Kansas, Sept. 2006. University of Utah, Salt Lake City, Utah, Dec. 2007. The Kitasato Institute, Tokyo, Japan, Feb. 2007. Tokyo Medical and Dental University, Tokyo, Japan, Feb. 2007. ICCA-X, Nashville, Tennessee, Aug. 2007. Rice University, Houston, Texas, Aug. 2007. Texas A&M University, College Station, Texas, Aug. 2007. University of Texas in Austin, Austin, Texas, Aug. 2007. University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, Feb. 2008. 7th US-Japan Seminar on the Biosynthesis of Nat. Prod., San Diego, California, Jun. 2008. Rutgers Chemistry/Robert Wood Johnson Medical School, Rutgers, New Jersey, Sept. 2008. University of Minnesota, Twin Cities, Minnesota, Nov., 2008. Gordon Research Conference – Bioorganic Chemistry, Andover, New Hampshire, Apr. 2009. University of Florida, Gainesville, Florida, Sept. 2009. Harvard Medical School, Boston, Massachusetts, Oct. 2009. University of Alabama Birmingham, Birmingham, Alabama, Nov. 2009. The Johns Hopkins University, Baltimore, Maryland, Feb. 2010. Antibacterial Drug Discovery and Development Gordon Conference, Galveston, Texas, Mar. 2010. American Chemical Society, National Meeting, San Francisco, California, Mar. 2010. Virginia Tech, Blacksburg Virginia, Sept. 2010. American Chemical Society PacifiChem National Meeting, Hawaii, Dec. 2010.

Graduate Recruiting Presentations Tennessee Tech, Cookeville, Tennessee , Aug. 2004. MTSU, September 2004, Murfreesboro, Tennessee, Sept. 2004. Kennesaw State University, Kennesaw, Georgia, Oct. 2004. Elon University, Elon, North Carolina, Oct. 2004. Centenary College, Centenary, Shreveport, Louisiana, Mar. 2005. University of Alabama, Huntsville, Alabama, Oct. 2005. Prairie View A&M, Prairie View, Texas, Oct. 2006. Florida International University, North Miami, Florida, Mar. 2008.

Published Abstracts and Poster Presentations • Identification and characterization of new cytotoxic agent from actinomycetes (ECO-04601), Dimitriadou, V., McAlpine, J., Zazopoulos, E.,Bachmann, B.O., Berger, F., Pelletier, L.m,

10

Alaoui-Jamali, M., Farnet, C.F. American Association for Cancer Research - AACR 95th Annual Meeting, Orlando, Florida, March 27-31, 2004 • Biosynthesis of K-26, a phosphonopeptide produced by an actinomycete, Ntai I., Du Y., Hachey, D.L., Manier, L., Bachmann, B.O., Bioorganic Chemistry Gordon Conference • Directed Evolution of Azole Nucleotide Biosynthesis. Scism, R.A., Bachmann, B.O., Society for Industrial Microbiology Chicago 09/2005 • Investigating the Biosynthesis of C-P Bond Containing Natural Product K-26 by Mass Spectrometry, Ntai, I., Du, Y., Phelan, V.V, Bachmann, B.O., Society for Industrial Microbiology Baltimore 08/2006

TEACHING RELATED ACTIVTIES

New courses developed (with overall instructor rating our of 5.00) • CHEM 225 Spectroscopic Identification of Organic Compound (graduates and undergraduates) o Spr. 2003, 20 enrolled (4.50/5.00) o Spr. 2005, 19 enrolled (4.62/5.00) o Spr.2006, 23 enrolled (4.04/5.00) o Fall 2008, 20 enrolled (4.00/5.00) o Spr. 2008, 6 enrolled (4.33/5.00) • CHEM 218 Honors Organic Chemistry (undergraduate) o Fall 2004, 40 enrolled (4.00/5.00) o Fall 2005, 48 enrolled (4.53/5.00) • CPB 320 Fundamentals of Chemical Biology (graduate) o Spring 2006, 16 enrolled (4.15/5.00) o Spring 2007, 18 enrolled (3.91/5.00) o Spring 2008, 13 enrolled (unknown) o Spring 2009, 19 enrolled (4.26/5.00) o Spring 2010, 22 enrolled (4.52/5.00) • CHEM 301 Chemistry Seminar (graduate)

PhD. Advising • Rob Scism, Directed Evolution and Pathway Engineering for Nucleotide Analogue Biosynthesis, (2010). Currently seeking employment. • Yunfeng Hu, Microbial Biosynthesis of Benzodiazepines and Nitrosugar Containing Natural Products, (2009). Post doctoral Research Associate, Brown University • Ioanna Ntai, Biosynthetic studies of secondary metabolites by mass spectrometry, (2008). Post Doctoral Research Associate, University of Illinois Urbana-Champaign • David Nannemann (5th Year) • Vanessa Phelan (5th Year) • Ahmad Al-Mestarihi (4th year) • Glenna Kramer (2rd year) • Cynthia McNees (2rd year) • William Birmingham (2rd Year)

Masters Advising 11

• Lindsey Frilling (graduated 2005) – Graduate school in Pharmacy • Andrea Sease (Graduated 2010) – Teaching high school

Post Doctoral Research Advising: Dr. Yu Du, Dr. Jaeheon Lee

Undergraduate Research Advising • Opeyemi Ajai (2004) – Meharry Medical School • David Good, Spring/Summer (2004) – Graduate School, Chemistry, Wisconsin • Zack DePhillipe (2005-2006) – Ben Gurion University of the Negev, Joyce & Irving Goldman Medical School • Laila Hassam-Malani (2006) – Vanderbilt Medical School • Rachel Clarke (2008) – Undergraduate • Mary Boyd (2009) – Undergraduate • Connor Lamberson (2009). – Undergraduate

Mentoring committees: Served on mentoring committees for over 56 students, mediating Preliminary exams, Qualifying exams, Independent Research Proposals and Dissertations at Vanderbilt University.

SERVICE

• Chair of Graduate Recruiting in Chemistry, 2005-2007 • VICB Operations Committee 2009 – current • CBI Training Grant Executive Committee, 2008 - current • Graduate recruiting committee. • VICB faculty search committee • Funding Agency Study Section: Reviewer for the Petroleum Research Fun Type G- Grant award, Aug. 2004 Study Section Member for Program Project Award, NIH, Dec. 2005 Study Section Member (Ad Hoc) for SBC-B, NIH, Feb 2006, Feb2010 Study Section Member (Ad Hoc) for Challenge Grants, NIH, June 2009 • Conference Organization: Session Chair, Society for Industrial Microbiology Annual Meeting July 2006 Organizing Committee: 10th International Conference on the Chemistry of Antibiotics and other Bioactive Compounds (ICCA-10), Nashville Tennessee Summer 2007 • Textbook reviewer for Chemical Biology, Clardy et al.

12