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(12) Patent Application Publication (10) Pub. No.: US 2014/0161955 A1 Wadhwa (43) Pub

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(12) Patent Application Publication (10) Pub. No.: US 2014/0161955 A1 Wadhwa (43) Pub US 2014O161955A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0161955 A1 Wadhwa (43) Pub. Date: Jun. 12, 2014 (54) LIQUID DIETARY SUPPLEMENT (57) ABSTRACT FORMULATION COMPOSITIONS This invention relates to liquid dietary Supplement formula tion compositions that provide dietary minerals and addi (71) Applicant: Manpreet S. Wadhwa, Thousand Oaks, tional optional ingredients beneficial for health; methods of CA (US) design and manufacture of Such compositions; and methods to enable convenient oral ingestion of the formulation ingre (72) Inventor: Manpreet S. Wadhwa, Thousand Oaks, dients, by adding the formulations to drinking water, bever CA (US) ages, foods, or meals. The formulation compositions of this invention generally include water, water-soluble calcium (21) Appl. No.: 13/712,328 compound(s), water-soluble magnesium compound(s), and additional optional ingredients, wherein the Sum of the con centrations of the calcium and magnesium compounds is (22) Filed: Dec. 12, 2012 most preferably 2 molar or more, up . the point of No. The formulations of this invention possess inherent resistance Publication Classification to microbial growth. The formulations of this invention and variations thereof can be used as dietary Supplements to (51) Int. Cl. increase intake of beneficial minerals, to mineralize water, to A2.3L I/304 (2006.01) fortify foods or beverages, and can also be used to prepare a (52) U.S. Cl. variety of additional liquid formulations by varying the cal CPC ...................................... A2.3L I/304 (2013.01) cium and magnesium compounds, and/or by adding one or USPC ........................................... 426/590: 426/648 more compatible ingredient(s). US 2014/01 6 1955 A1 Jun. 12, 2014 LIQUID DIETARY SUPPLEMENT and antineoplastic medications may cause excessive loss of FORMULATION COMPOSITIONS magnesium. Diabetes may result in magnesium loss due to increased magnesium loss in urine due to hyperglycemia. CROSS REFERENCE TO RELATED Alcoholism is associated with low blood levels of magne APPLICATION sium, and individuals with chronic malabsorptive problems Such as those with Chrohn's disease, gluten sensitive enter 0001. This application claims the benefit of priority to opathy, regional enteritis, or intestinal Surgery are also at risk U.S. Provisional Application Ser. No. 61/569,790 filed on for magnesium deficiency. Dec. 13, 2011. 0006 Given the number of people at risk for calcium and magnesium deficiency, there is an ongoing need for effective FIELD OF THE INVENTION dietary Supplements that can provide or improve an intake of 0002 The present invention relates generally to dietary these minerals to help meet nutritional requirements while Supplements and more specifically it relates to liquid dietary being convenient and easy to use for the consumer. There are Supplement formulation compositions that generally include many dietary Supplements containing calcium and magne water-soluble dietary minerals and additional optional ingre sium compounds that are commercially available or dients that are beneficial for health; methods of designing and described in prior literature. The vast majority of these are producing Such formulation compositions, and methods to Solid dosage forms, such as tablets, capsules, or powders. enable convenient oral ingestion of the formulation ingredi Although these Supplements are relatively inexpensive, they ents, by adding the formulations to drinking water, beverages, have some disadvantages. Absorption of the nutrients from or meals. these Supplements tends to be quite variable, and large tablets or capsules are frequently not suitable for pediatric, geriatric BACKGROUND OF THE INVENTION and some patient populations. Liquid dosage forms of cal 0003 Calcium is the most abundant mineral in the body cium and magnesium possess Some advantages over the Solid and plays both a structural and functional role in maintaining dosage forms in terms of better absorption, convenience of human health. While most of the body's calcium is stored in use and dosing flexibility, but are less commonly available. the bones and teeth, calcium also serves a critical role in The liquid formulations tend to have stability limitations and processes such as vascular contraction and vasodilation, are vulnerable to microbial growth in the absence of addi muscle function, nerve transmission, and hormonal Secretion. tional preservatives. Almost all marketed liquid formulations The calcium ion is also a ubiquitous cellular messenger, and of calcium and magnesium are particulate suspensions that stimulates a variety of enzymes and other target proteins. tend to settle, and carry a requirement to “shake well before 0004. There are a number of factors that put people at risk use’. These products can have variable absorption, depending for diseases associated with inadequate calcium intake. Cal upon the Suspension characteristics, and can lead to incorrect cium absorption decreases in adulthood and continues to dosing if not shaken well prior to use. There are few liquid decrease as people age. In aging adults, bone breakdown products where the calcium and magnesium are completely exceeds formation, resulting in bone loss. In women, meno dissolved in water and present in an ionic state to provide pause leads to bone loss because decreases in estrogen pro optimal absorption upon ingestion. However, the calcium and duction both increase bone resorption and decrease calcium magnesium mineral concentrations of Such formulations are absorption. Negative effects on calcium balance have also relatively low compared to those of the Suspension liquid been observed in amenorrhic women of childbearing age. products, and thus require relatively large Volume dosages to Further, a number of people who avoid dairy products due to meet the recommended daily allowances. Thus, there is a lactose intolerance or veganism are also at risk for calcium need for improved liquid dietary Supplement formulations inadequacy. Bone health measures serve as a basis for deriv where calcium and magnesium are present in relatively high ing measures Such as Recommended Dietary Allowances for concentrations, are completely dissolved, and are inherently calcium, and inadequate calcium intake increases the risk for stable and resistant to microbial growth. osteoporosis, a disorder characterized by porous and fragile BRIEF SUMMARY OF THE INVENTION bones which affects more than 10 million U.S. adults. In addition to its effects on bone health, calcium intake has been 0007. The invention generally relates to liquid dietary proposed to have beneficial effects on reducing cardiovascu Supplement compositions which include water, water-soluble lar disease risk, lowering blood pressure, and prevention of calcium compound(s), water-soluble magnesium compound colorectal cancer and prostate cancer. (S), and optional ingredients. The total sum of concentrations 0005 Magnesium is another essential mineral in the body. of the dissolved calcium and magnesium compounds is About half of total body magnesium is found in bone, while higher than the dissolved concentrations found in currently the other half is found within body tissues. Magnesium is available liquid supplements, and is at least 1 Molar. These required for more than 300 biochemical reactions in the body, compositions possess resistance to microbial growth which and is important for maintaining the function of muscles and allows reduction or elimination of additional preservatives in nerves, Supporting the immune system, maintaining bone the compositions. Thus the compositions possess Some useful health, regulating blood Sugar levels, maintaining normal features that are not found in the existing soluble liquid com blood pressure, and playing a role in energy metabolism and positions of calcium and magnesium. protein synthesis. Dietary studies suggest that many Ameri 0008. There have thus been outlined, rather broadly, some cans do not get adequate amounts of magnesium. As magne of the features of the invention in order that the detailed sium absorption is regulated by the intestines and excretion is description thereof may be better understood, and in order regulated by the kidneys, conditions affecting these organs that the present contribution to the art may be better appreci may result in magnesium deficiency. For example, medicines ated. There are additional features of the invention that will be that affect the kidneys such as diuretics and some antibiotics described hereinafter. In this respect, it is to be understood US 2014/01 6 1955 A1 Jun. 12, 2014 that the invention is not limited in its application to the details 0020 “Water solubility” as used herein means the maxi of construction or to the arrangements of the components set mum amount of a compound or ingredient that will dissolve forth in the following description. The invention is capable of in pure water at a given temperature. other embodiments and of being practiced and carried out in (0021 “Water soluble” (or “water-soluble') as used herein various ways. Also, it is to be understood that the phraseology means an ingredient, element or material capable of dissolv and terminology employed herein are for the purpose of the ing in water, by going into a liquid aqueous state, either description and should not be regarded as limiting. spontaneously or by employing commonly used methods to 0009. An object of the invention is to provide liquid aid dissolution Such as shaking, mixing, heating,
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