Academic Curricula

ACADEMIC CURRICULA

POSTGRADUATE DEGREE PROGRAMME

(REGULATIONS 2021)

MASTER OF SCIENCE (M.Sc. Organic Chemistry)

Two Years(Full-Time)

Learning Outcome Based Curriculum Framework (LOCF)

Academic Year

2021 - 2022

SRM INSTITUTE OF SCIENCE AND TECHNOLOGY

(Deemed to be University u/s 3 of UGC Act, 1956)

Kattankulathur, Chengalpattu District 603203, Tamil Nadu, India

TABLE OF CONTENT

DEPARTMENT VISION STATEMENT III

DEPARTMENT MISSION STATEMENT III

PROGRAM EDUCATION OBJECTIVES (PEO) III

PROGRAM SPECIFIC OUTCOMES (PSO) III CONSISTENCY OF PEO’S WITH MISSION OF THE DEPARTMENT III

CONSISTENCY OF PEO’S WITH PROGRAM LEARNING OUTCOMES (PLO) IV

PROGRAMME STRUCTURE V

COURSE STRUCTURE VI IMPLEMENTATION PLAN VII

PROGRAM ARTICULATION MATRIX VIII

SEMESTER I PCY21101J Chemical Kinetics, Electrochemistry and Surface Chemistry 1

PCY21102J Transition Metal Chemistry 4 PCY21103T Organic Chemistry: Structure and Reactivity 7

PCY21D01T Chemical Bonding, Molecular Geometry and Group Theory 10

PCY21D02T Materials Chemistry 13

PCY21D03T Advanced Polymer Science 16 PCY21S01J Fundamentals of Cheminformatics 19

PCD21AE1T Professional Skills and Problem Solving 21

SEMESTER II POC21201T Spectroscopy and Applications in Organic chemistry 23 POC21202T Transformations in Organic Chemistry 26

POC21203T Heterocyclic Chemistry and Total synthesis of Natural products 29

POC21204T Modern Methods of Organic Synthesis 32

PCY21D04T Nanomaterials and Nanochemistry 35 POC21D01T Advanced Green Chemistry 38

POC21D02T Asymmetric and Enzymatic Synthesis 41

POC21S01L Organic Chemistry Practical: Functional group analysis and synthesis 44

PCD21AE2T General Aptitude for Competitive Examinations 46

SEMESTER III

POC21301T Modern Synthetic Reagents and Photochemistry 48

POC21302T Bioorganic Chemistry 51

POC21303T Medicinal Chemistry and Drug Design 54 PCY21D05T Supramolecular Chemistry and Crystal Engineering 56

POC21D03T Organometallic Chemistry and Catalysis 59 POC21D04T Industrial Organic Chemistry 62

I M.Sc.Organic Chemistry PPY21G01T Energy Storage and Devices 65

PPY21G03T LASER Physics 67

PCY21G01T Research Skills and Learning 69 POC21S02L Advance Organic Chemistry Practical 71

POC21I01L Massive Open Online Course 73

POC21I02L Internship 74

PCD21AE3T Employability Skills 75

SEMESTER IV

POC21P01L Project Work 77

GENERIC ELECTIVES OFFERED BY CHEMISTRY DEPARTMENT PCY21G01T Research Skills and Learning 69

PCY21G02T Chemistry of Biomolecules 79

II M.Sc.Organic Chemistry

SRM INSTITUTE OF SCIENCE AND TECHNOLOGY Kattankulathur, Chengalpattu District 603203, Tamil Nadu, India

DEPARTMENT OF CHEMISTRY

1. Department Vision Statement Stmt - 1 To be a nationally and an internationally-acclaimed hub for high-level teaching In chemistry Stmt - 2 To impart research-based education to students in the field of Organic chemistry Stmt - 3 To Implement the global standards and nurturing the students through innovation and quality education.

2. Department Mission Statement Stmt - 1 To provide comprehensive specialist expertise in the domain of chemistry To motivate the next generation graduates to effectively contribute to the advancement of society with integrity and Stmt - 2 commitment Stmt - 3 To attain entrepreneurship and self-empowerment in the area of chemical sciences.

3. Program Education Objectives (PEO) PEO - 1 To develop critical analysis and problem solving skills required in the field of Chemistry To prepare students with a working knowledge of experimental techniques and instrumentation required to work PEO - 2 independently in research or industrial environments. To develop student strength in organizing and presenting acquired knowledge coherently both orally and in written PEO - 3 discourse. PEO - 4 To prepare the students to successfully compete for current employment opportunities PEO - 5 To develop an ability to be socially intelligent with good SIQ (Social Intelligence Quotient) and EQ (Emotional Quotient)

4. Program Specific Outcomes (PSO) To provide in-depth knowledge about the terms, concepts, methodologies, principles and experimental techniques PSO - 1 involved in the various fields of chemistry. PSO - 2 To Work in the pure, interdisciplinary and multidisciplinary areas of chemical sciences and its applications To prepare the students with a working knowledge of experimental techniques and instrumentation required to work PSO - 3 independently in research or in other industrial environments.

Mission Stmt. - 1 Mission Stmt. - 2 Mission Stmt. - 3

PEO - 1 H H H PEO - 2 M H M PEO - 3 M H H PEO - 4 H H M PEO - 5 M M M

H – High Correlation, M – Medium Correlation, L – Low Correlation

III M.Sc.Organic Chemistry

5. Consistency of PEO’s with Program Learning Outcomes (PLO) Program Learning Outcomes (PLO)

1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15.

Directed

Disciplinary Knowledge Critical Thinking Problem Solving Analytical Reasoning Research Skills TeamWork Scientific Reasoning Reflective Thinking Self Learning Multicultural Competence Ethical Reasoning Community Engagement ICTSkills Leadership Skills LifeLong Learning PEO - 1 H H H H H L H L H L L H M H H PEO - 2 H M M H H H H M M M M M H H H PEO - 3 H H H H H H H M H H H H H L H PEO - 4 H H M H H H H H H H H H M M H PEO - 5 M M H H M H M H H H H H H H H

H – High Correlation, M – Medium Correlation, L – Low Correlation

IV M.Sc.Organic Chemistry 6. PG Programme Structure (Total Credits:80)

1. Professional Core Courses (C) 2. Discipline Elective Courses

(10 Courses) (D) Hours/ (3 Courses) Course Course Week Hours/ Code Title Course Course L T* P C Week Code Title Chemical Kinetics, Electrochemistry L T P C PCY21101J 2 0 4 4 Chemical Bonding, Molecular and Surface Chemistry PCY21D01T Geometry and Group Theory PCY21102J Transition Metal Chemistry 2 0 4 4 3 1 0 4 Organic Chemistry: Structure and PCY21D02T Materials Chemistry PCY21103T 3 1 0 4 Reactivity PCY21D03T Advanced Polymer Science Spectroscopy and Applications in Nanomaterials and POC21201T 3 1 0 4 PCY21D04T Organic chemistry Nanochemistry Transformations in Organic POC21D01T Advanced Green Chemistry 3 1 0 4 POC21202T 3 1 0 4 Spectroscopy and Applications Chemistry POC21D02T Heterocyclic Chemistry and Total in Organic chemistry POC21203T 3 1 0 4 Supramolecular Chemistry and synthesis of Natural products PCY21D05T Modern Methods of Organic Crystal Engineering POC21204T 3 1 0 4 Organometallic Chemistry and 3 1 0 4 Synthesis POC21D03T Modern Synthetic Reagents and Catalysis POC21301T 3 1 0 4 Photochemistry POC21D04T Industrial Organic Chemistry Total Learning Credits 12 POC21302T Bioorganic Chemistry 3 1 0 4 Medicinal Chemistry and Drug POC21303T 3 1 0 4 Design Total Learning Credits 40

3. Generic Elective Courses (G) (Any 1Course)

Hours/ Course Course Week 4. Skill Enhancement Code Title L T P C Courses(S) PPY21G01T Energy Storage and Devices (3 Courses) PPY21G03T LASER Physics 3 0 0 3 Hours/ PCY21G01T Research Skills and Learning Course Course Total Learning Credits 3 Week Code Title L T P C Fundamentals of 5. Project Work, Internship In PCY21S01J 1 0 2 2 Industry / Higher Technical Cheminformatics

Institutions(P) Organic Chemistry Practical: Hours/ POC21S01L Functional groupm analysis and 0 0 6 3 Course Course Week synthesis Code Title Advance Organic Chemistry L T P C POC21S02L 0 0 6 3 POC21I01L Massive Open Online Course 0 0 0 2 Practical POC21I02L Internship 0 0 0 2 Total Learning Credits 8 POC21P01L Project Work 0 0 24 12 Total Learning Credits 14 6.Ability Enhancement Courses (AE) (3 Courses) Hours/ Course Course Week Code Title L T P C Professional Skills and Problem PCD21AE1T 1 0 0 1 Solving General Aptitude for Competitive PCD21AE2T 1 0 0 1 Examinations PCD21AE3T Employability Skills 1 0 0 1 Total Learning Credits 3

* Additional one hour as open contact hour for each core courses

V M.Sc.Organic Chemistry Course Structure

Professional Discipline Generic Ability Core Electives Skill Enhancement Project Work, Total Total Semester ElectivesCours Enhancement Courses Courses Courses(SEC) Internship (P) Credits Hours es (GEC) Courses(AEC) (PCC) (DEC)

PCC-1(4)

Sem I PCC-2 (4) DEC-1 (4) SEC 1 (2) AEC 1 (1) 19 24 PCC-3(4)

PCC-4 (4) PCC-5 (4) Sem II DEC-2 (4)- SEC 2 (3) AEC 2 (1) 24 29 PCC-6 (4) PCC-7 (4) PCC-8 (4) P (internship) or Sem III PCC-9 (4) DEC-3(4) GEC -(3) SEC 3 (3) AEC 3 (1) 25 26 MOOC (2) PCC-10 (4)

Sem IV P (project) (12) 12 24

Total 40 12 3 8 3 14 80 103 Credits

VI M.Sc.Organic Chemistry 7. Implementation Plan

Semester - II Hours/ Semester - I Course Hours/ Course Title Week C Course Code Course Title Week C L T P Code Spectroscopy and Applications in L T P POC21201T 3 1 0 4 Chemical Kinetics, Organic chemistry Transformations in Organic PCY21101J Electrochemistry and Surface 2 0 4 4 POC21202T 3 1 0 4 Chemistry Chemistry Heterocyclic Chemistry and Total PCY21102J Transition Metal Chemistry 2 0 4 4 POC21203T 3 1 0 4 Organic Chemistry: Structure and synthesis of Natural products PCY21103T 3 1 0 4 Modern Methods of Organic Reactivity POC21204T 3 1 0 4 Chemical Bonding, Molecular Synthesis PCY21D01T Geometry and Group Theory PCY21D04T Nanomaterials and Nanochemistry 3 1 0 4 PCY21D02T Materials Chemistry Advanced Green Chemistry POC21D01T 3 1 0 4 PCY21D03T Advanced Polymer Science Asymmetric and Enzymatic POC21D02T PCY21S01J Fundamentals of Cheminformatics 1 0 2 2 Synthesis Professional Skills and Problem PCD21AE1T 1 0 0 1 Organic Chemistry Practical: Solving POC21S01L Functional groupm analysis and 0 0 6 3 Total Learning Credits 19 synthesis Total Number of Hours 24 General Aptitude for Competitive PCD21AE2T 1 0 0 1 [ Examinations Total Learning Credits 24 Total Number of Hours 29

Semester - IV Semester – III Hours/ Hours/ Course Course Course Title Week C Course Title Week C Code Code L T P L T P Modern Synthetic Reagents POC21P01L Project Work 0 0 24 12 POC21301T 3 1 0 4 and Photochemistry Total Learning Credits 12 POC21302T Bioorganic Chemistry 3 1 0 4 Total Number of Hours 24 Medicinal Chemistry and Drug POC21303T 3 1 0 4 Design Supramolecular Chemistry PCY21D05T and Crystal Engineering Organometallic Chemistry and 3 1 0 4 POC21D03T Catalysis POC21D04T Industrial Organic Chemistry PPY21G01T Energy Storage and Devices PPY21G02T LASER Physics 3 0 0 3 PCY21G01T Research Skills and Learning Total Learning Credits :80 Advance Organic Chemistry POC21S02L 0 0 6 3 Practical POC21I01L Massive Open Online Course 0 0 0 2 POC21I02L Internship 0 0 0 2 PCD21AE3T Employability Skills 1 0 0 1 Total Learning Credits 25 Total Number of Hours 26

VII M.Sc.Organic Chemistry 8. Program Articulation Matrix

Programme Learning Outcomes

Course Code Course Name

Knowledge

Engagement

DirectedLearning

Disciplinary CriticalThinking ProblemSolving AnalyticalReasoning ResearchSkills TeamWork Scientific Reasoning ReflectiveThinking Self Multicultural Competence EthicalReasoning Community ICTSkills LeadershipSkills LifeLong Learning Chemical Kinetics, Electrochemistry and Surface PCY21101J H H H H H M M M M M H H M H H Chemistry PCY21102J Transition Metal Chemistry H H H H H L M L M H M M H H H PCY21103T Organic Chemistry: Structure and Reactivity H H H H H M H M M M H H H M H POC21201T Spectroscopy and Applications in Organic chemistry H H H H H H H H H H H L M L H POC21202T Transformations in Organic Chemistry H H H H M M M H H H M M H M H Heterocyclic Chemistry and Total synthesis of Natural POC21203T H H H H H L M L M M H H M H H products POC21204T Modern Methods of Organic Synthesis H H H H H L M L M M H L M H H POC21301T Modern Synthetic Reagents and Photochemistry H H M H H L M L M H M M H H H POC21302T Bioorganic Chemistry H H H H H M H M M M H H H M H POC21303T Medicinal Chemistry and Drug Design H H H H H L M L M M H L M H H Chemical Bonding, Molecular Geometry and Group PCY21D01T H M M H H H M H H H H L M M H Theory PCY21D02T Materials Chemistry H M M H H H M H H H H L M M H PCY21D03T Advanced Polymer Science H H H H H L M L M M H H M H H PCY21D04T Nanomaterials and Nanochemistry H H H H H L M L M M H L M H H POC21D01T Advanced Green Chemistry H H H H H L M L M H M M H H H POC21D02T Asymmetric and Enzymatic Synthesis H H H H H M H M M M H H H M H PCY21D05T Supramolecular Chemistry and Crystal Engineering H M M H H H M H H H H L M M H POC21D03T Organometallic Chemistry and Catalysis H M H H M H M H H H M M H M H POC21D04T Industrial Organic Chemistry H H H H H L M L M M H H M H H PPY21G01T Energy Storage and Devices H H H H H L M L M H M M H H M PPY21G02T LASER Physics H H H H H M H M M M H H H M M PCY21G01T Research Skills and Learning M M H H M H M H H H M M H M M PCY21S01J Fundamentals of Cheminformatics H H H H H L M L M M H H M H H Organic Chemistry Practical: Functional groupm POC21S01L H H H H H L M L M H M M H H M analysis and synthesis POC21S02L Advance Organic Chemistry Practical H H H H H M H M M M H H H M M POC21I01L Massive Open Online Course M M H H M H M H H H M M H M M POC21I02L Internship M M H H M H M H H H M M H M M POC21P01L Project Work H H H H H L M L M M M H M H H PCD21AE1T Professional Skills and Problem Solving H H H H H M H M M M H H H M M PCD21AE2T General Aptitude for Competitive Examinations H M M H H H M H H H H L M M H PCD21AE3T Employability Skills M M H H M H M H H H M M H M M Program Average H H H H H L M L M H M M H H H

H – High Correlation, M – Medium Correlation, L – Low Correlation

VIII M.Sc.Organic Chemistry

SEMESTER I

Course Course Chemical Kinetics, Electrochemistry and Course L T P C PCY21101J C Professional Core Course Code Name Surface Chemistry Category 2 0 4 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

To help the student to understand the basic principles of CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 chemical kinetics. To gain the knowledge of chemical reaction in solutions CLR-2 : and effect of dielectric constants. CLR-3 : To gain deeper insight of complex and fast reactions. To gather basic knowledge of general acid base CLR-4 : catalyzed reaction and enzyme catalyzed reaction.

CLR-5 : To gain knowledge of the basic electrochemistry.

To understand the mechanism of surface adsorption

CLR-6 : process in terms of thermodynamics and chemical

kinetics.

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life CLO-1 : understand the basic principles of chemical kinetics. 2 75 60 H H H L H H M H H L H H H H H CLO-2 : gain knowledge about the fast reaction kinetics 2 80 70 H H L H L L H L L H H L H H H understand the mechanisms of chemical reactions in gas CLO-3 : 2 70 65 H H H M L L H L L H H L H H H phase and in liquid. acquaint the student with the fundamental concepts of CLO-4 : 2 70 70 H L H H H L M L L H H L H H H basic electrochemistry understand the basic principles of chemisorption, BET and CLO-5 : 2 80 70 L H L M L H H L L H H L H H H BET related isotherms. understand the principles of determination of molecular CLO-6 : weight, phase diagram of two components forming a 2 75 70 H H H H H H H H H H H H H H H simple eutectic, rate of polymerization of acrylamide

Duration 18 18 18 18 18 (hour) Electromotive Solvent effects on Adsorption of SLO- Simple collision force - Equilibrium isotope reaction rates, cage gases and 1 theory measurement of effects effect vapors on solids EMF S-1 factors determining the absolute reaction rates in Langmuir SLO- the cell EMF and primary kinetic isotope reaction rate solution adsorption 2 the cell reaction effects, theory (ARRT) (based on transition isotherm state theory) kinetic and thermodynamic reversible statistical treatment, cells - types of SLO- secondary kinetic derivation of potential reactions between ions half cells - 1 isotope effects Langmuir energy classification of adsorption surfaces cells isotherm S-2 kinetic and the standard EMF application of statistical ion-dipole and dipole of a cell - SLO- ARRT to simple Fast reactions: derivation of dipole electrochemical 2 bimolecular relaxation kinetics Langmuir reactions, potential - standard process adsorption electrode potentials isotherm SLO- Introduction Determination of Ea of Determination of Ea Study of phase S-3-6 1 Determination of effect and saponification of Ester of saponification of diagram of three

1 M.Sc.Organic Chemistry Duration 18 18 18 18 18 (hour) demonstration by conductometry Ester by of impurity on the CST of components SLO- 2 of the lab method conductometry phenol- water system system instrument method structure, significance Fast reactions: relaxation chain reactions, SLO- of volume and calculation of the kinetics, chemical adsorption general 1 entropy of activation, EMF of a cell relaxation in two step and entropies characteristics pressure effect, multi-step synthesis S-7 study of kinetics experimental methods for SLO- of chain reaction Primary and secondary Nernst equation lateral the study of relaxation 2 like H2-Br2 salt effects. and its limitations interactions kinetics and applications reaction Kinetics of decomposition of electrode experimental methods for the BET and SLO- photophysical and acetaldehyde concentration the study of relaxation related 1 photochemical and N2O5 cells kinetics and applications isotherms S-8 processes, theory of complex photochemical the BET and SLO- cells with liquid 2 unimolecular processes, temperature jump method related junctions reactions, homogeneous catalysis isotherms SLO- Determination Determination of Determination of Determination of 1 of rate constant molecular weight of strength of an Iron Study of phase diagram of rate of S-9-12 of Acid substance by solution by two components forming a SLO- polymerization hydrolysis of an Transition Potentiometric simple eutectic 2 of acrylamide ester Temperature method method SLO- Lindemann, general catalytic decomposition diffusion controlled derivation of the 1 Hinshelwood mechanisms, voltages reactions BET equation S-13 concentration SLO- steady state diffusion controlled properties of the acid-base catalysis, polarisation and 2 approximation reactions BET equation over voltage Kinetics of thermodynamics principle of electrode process. fluorescence quenching, SLO- of adsorption microscopic catalysis by enzymes, Electrical aspects Electrochemical 1 chemisorption reversibility of surface methods and catalysis chemistry, electrical double S-14 layer, Stern influence of treatment of the SLO- And detailed concentration (single common ion inhibition, kinetics of electrical double 2 balancing substrate, double flash photolysis chemisorption layer, free energy of substrate) a diffuse double layer SLO- Determination Determination of 1 of order, effect equivalent Determination of Determination of of ionic conductance, degree Critical Solution Study of phase diagram integral and S-15- 18 SLO- strength on rate of dissociation and Temperature of two components differential heat 2 constant of dissociation constant (CST) of phenol- forming a compound of solutions by Persulphate- of weak acid by water system colorimetry. Iodine reaction. conductometry.

1. K.J. Laidler, Chemical Kinetics, Tata McGraw Hill Learning 2. Gurdeep Raj, Chemical Kinetics, Goel Publishing House. Resources 3. P.W.Atkins, Physical Chemistry 4. P.C. Hiemenz, Principles of colloids and surface chemistry,2ndEd.,Marcel DekkerInc., 1986.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% 30% 30% 30% 30% 30% 30% 30% 30% 30% Understand Level 2 Apply 40% 40% 50% 50% 50% 50% 50% 50% 50% 50%

2 M.Sc.Organic Chemistry Analyze Evaluate Level 3 30% 30% 20% 20% 20% 20% 20% 20% 20% 20% Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Experts from Industry Expert from Higher Technical Institutions Internal Experts Prof. G. Sekar, Department of Chemistry, IIT Madras 1. Dr. Manab Kundu, SRMIST Dr. Ravikiran Allada, Head R&D, Analytical, Novugen Email: [email protected] Pharma, Malaysia Dr. Kanishka Biswas, Jawaharlal Nehru Email: [email protected] Centre for Advanced Scientific Research 2. Dr. M. Arthanareeswari, SRMIST (JNCASR), Bengaluru Email: [email protected]

======

3 M.Sc.Organic Chemistry

Course Course Course L T P C Transition Metal Chemistry C Professional Core Course Code PCY21102J Name Category 2 0 4 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

motivate the learners to understand the different types CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 coordination complexes. distinguish and intervene the theories of coordination CLR-2 : complexes of d-block elements with variable configurations. identify as well as to predict the feasibility and stability of CLR-3 : coordination complexes compare the physicochemical properties of the CLR-4 : complexes against spectroscopic and magnetic properties.

study the synthetic strategies based on the reactivity with

CLR-5 :

respect to structural and fundamental factors.

acquire the trend and features of compounds of

CLR-6 :

lanthanides and actinides.

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life One can deduce the structure of different types of CLO-1 : 2 75 60 H H H L H H M H H L H H H H H coordination complexes. It is possible to correlate the gradational development of CLO-2 : theories of coordination complexes due to splitting of 2 80 70 H H L H L L H L L H H L H H H orbitals. To predict the spectroscopic and magnetic properties of CLO-3 : 2 70 65 H H H M L L H L L H H L H H H the metal-ligand coordination spheres. To conclude the type of reactions to be occurred with the CLO-4 : 2 70 70 H L H H H L M L L H H L H H H variety of the metal complexes To understand the versatile mechanistic pathways CLO-5 : associated with the reactions of different coordination 2 80 70 L H L M L H H L L H H L H H H sphere To appreciate the significance of f-block elements CLO-6 : 2 75 70 H H H H H H H H H H H H H H H chemistry based on their characteristic properties.

Duration 18 18 18 18 18 (hour) Introduction Lanthanides: Ligand substitution SLO- monodentate, Valence bond theory: Magnetic properties of tetrahedral lanthanide series, reactions in octahedral, 1 bidentate, and hybridization, and octahedral complexes abundance and square planar complexes, polydentate ligands natural isotopes S-1 lanthanide para, dia, ferromagnetism and labile and inert complexes coordination sphere contraction, similarity SLO- geometry, magnetism, antiferro magnetism, (application of VBT, coordination in properties, 2 drawbacks of VBT determination of magnetic MOT), dissociation, number occurrence, oxidation properties, Gouy’s method association mechanism, states, nomenclature of Crystal field theory: mechanism of hydrolysis chemical SLO- mononuclear and crystal field effects, anomalous magnetic moment, reactions, acid hydrolysis, properties of Ln(III) 1 dinuclear assumptions of crystal thermal effects base hydrolysis, anation cations complexes field theory, reactions, crystal field splitting in magnetic S-2 octahedral and properties, colour chelate effect, tetrahedral geometries, single molecular magnets, spin trans effect, trans SLO- and electronic Werner‘s theory qualitative crystal field and orbital contribution influence, trans effect and 2 spectra of and Sidgwick theory splitting diagrams, high- quenching, its application, lanthanide spin and low-spin compounds, complexes SLO- Preparation of 1 Introduction to Synthesis of Metal triphenyl Cis and trans isomers of S-3-6 Inorganic acetylacetonate Preparation of Ferrocene. phosphine (Ph3P), SLO- [Co(en)2Cl2]Cl Chemistry Lab complex and transition 2 metal complexes

4 M.Sc.Organic Chemistry Duration 18 18 18 18 18 (hour) theories of trans effect, separation of thermodynamic and EAN and formation of CFSP and factors Spin cross over rule, microstates lanthanides, SLO- kinetic stability of metal-metal bond in affecting it, of electron configuration in free solvent extraction, 1 complexes, factors dimers computation of CFSE atoms and ions ion exchange affecting stability of metal method S-7 complexes separation of evidences of crystal term symbols for stability of complexes, experimental lanthanides, SLO- field splitting, equivalent and nonequivalent determination of determination of stability solvent extraction, 2 spectrochemical electrons, possible term symbols stability constants constant of complexes ion exchange series for given configuration, method Jahn-Teller theorem, crystal field splitting Electron transfer Actinides: actinide p2 -d2 splitting of terms in square Jobs method, in tetragonally reactions, one electron series, abundance SLO- planar, tetrahedral, octahedral stepwise stability distorted octahedral transfer reactions, inner and natural 1 fields, electronic spectra of constant geometry and in sphere mechanism, outer isotopes, various complexes, square planar sphere mechanism occurrence S-8 geometry Jahn-Teller theorem, preparation of overall stability Electron transfer crystal field splitting in actinides, constant, factors selection rules, spin orbit reactions, one electron SLO- tetragonally distorted oxidation states, affecting stability of coupling, assignment and transfer reactions, inner 2 octahedral geometry general properties, coordination intensities of transitions sphere mechanism, outer and in square planar the later actinide compounds sphere mechanism geometry elements, SLO-Determination of Preparation of (N,N)- Reaction of Cr(III) with Reaction of Mixed 1 Cr(III) complexes. S-9- Tin(IV) iodide, Tin(IV) bis(salicyldehyde)ethylenediamine multidentate ligands, a valence dinuclear [Cr(H2O)6]NO3.3H2O; 12 SLO- chloride, and Tin(II) Salen H2; and its cobalt complex kinetics experiment - complex of [Cr(H2O)4Cl2]Cl.2H2O; 2 iodide. [Co(Salen)] Vanadyl acetylacetonate. Mangenese(III,IV). [Cr(en)3]Cl3; Cr(acac)3 Orgel Marcus theory and its uranium- (d1 to d9 octahedral and applications, two electron occurrence, charge of central covalency in SLO- tetrahedral complexes) and transfer reactions metallurgy; metal ion, size of transition metal 1 Tanabe Sugano diagrams(d1,d6 complementary and non - chemical central metal ion complexes, complexes complementary electron properties of and its applications), transfer reactions hydrides, S-13 evidences for Orgel uranium- covalency, intensity (d1 to d9 octahedral and synthesis of coordination occurrence, of d-d transitions, SLO-chelate ring size, tetrahedral complexes) and compounds using electron metallurgy; spin-spin splitting, 2 steric effects Tanabe Sugano diagrams(d1,d6 transfer reactions, metal chemical hyperfine complexes assisted reactions properties of splitting, adjusted and its applications), hydrides, crystal field theory. Isomerism: linkage, MO Theory: metal aldol condensation, ester calculation of D0 and b and oxides, and ionization, hydrate, orbitals and LGOs hydrolysis,phosphate SLO- Racah parameters, examples halides, complexes coordination, suitable for σ and π ester, aminoesters and 1 from d2, d3 d7, d8 of lanthanides and coordination bonding in octahedral amide hydrolysis, octahedral complexes actinides. position isomerism, geometry, template effect, S-14 construction of geometrical (cis synthesis of oxides, and qualitative MO SLO- and trans, and fac charge transition spectra of metal macrocyclic ligands, halides, complexes energy level diagram 2 and mer) and complexes reaction of coordinated of lanthanides and for bonding in optical isomerism. ligands. actinides. octahedral geometry. SLO- Synthesis of 1 inorganic complexes characterization by Any one new novel Potentiometer S-15- Analysis of metal complexes to pH meter based physicochemical synthesis reported in based 18 SLO- deduce its structure. measurements methods, viz. FT- recent literature measurements 2 IR, UV, Vis, NMR and magnetic susceptibility etc.

1. D. F. Shriver and P. W. Atkins, Inorganic Chemistry, 3rdEd., W. H. Freeman and Co, London, 1999. 2. J. E. Huheey, E. A. Kieter and R. L. Keiter, Inorganic Chemistry, 4thEd., Harper Collins, New York, 1993 3. F. A. Cotton, G. Wilkinson and P.L.Gaus, Basic Inorganic Chemistry, 3rd Ed., John Wiley, New York, 2008. 4. N.N. Greenwood and A.Earnshaw, Chemistry of the Elements, 2nd Ed., Pergamon Press, Oxford, 2005 (Reprint). Learning 5. B.Douglas, D.McDaniel and J.Alexander, Concepts and Models of Inorganic Chemistry, 3rd Ed., Wiley, 2013. Resources 6. Inorg. Synth. 1957, 5, 130; 1963, 1, 183. 7. J. Chem. Soc., 1960, 4369. 8. J. Chem., Educ., 1980, 57, 316; 1978, 55, 55. 9. J. Chem. Educ. 1966, 43, 73; 1976, 53, 730. 10. Inorg. Synth. 1953, 4 119.

5 M.Sc.Organic Chemistry 11. J. Chem. Educ. 1977, 54, 443, 1973, 50, 670.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% 30% 30% 30% 30% 30% 30% 30% 50% 50% Understand Apply Level 2 40% 40% 50% 50% 50% 50% 50% 50% 50% 50% Analyze Evaluate Level 3 30% 30% 20% 20% 20% 20% 20% 20% 40% 60% Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Expert from Higher Technical Experts from Industry Internal Experts Institutions Prof. G. Sekar, Department of Chemistry, 1. Dr. T. Senthil Andavan, SRMIST IIT Madras Dr. Ravikiran Allada, Head R&D, Analytical, Email: [email protected] Novugen Pharma, Malaysia Dr. Kanishka Biswas, Jawaharlal Email: [email protected] Nehru Centre for Advanced Scientific Research (JNCASR), 2. Dr. M. Arthanareeswari, SRMIST Bengaluru Email: [email protected]

======

6 M.Sc.Organic Chemistry

Course PCY21103T Course Course L T P C Organic Chemistry: Structure and Reactivity C Professional Core Course Code Name Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

CLR-1 : gain exposure to the field of aromatic compounds 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 CLR-2 : gain knowledge about the mechanism of a reaction CLR-3 : learn about the reaction intermediates

CLR-4 : gain insight about how a molecule arrange in 3D space

know different types of reactions like substitution and

CLR-5 :

elimination

CLR-6 : learn about the reactivity of carbonyl compounds

Knowledge

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life CLO-1 : Understand the concept of aromaticity 2 75 60 H H H L H H M H H L H H H H H CLO-2 : Recognize reaction mechanism 2 80 70 H H L H L L H L L H H L H H H CLO-3 : Realize reaction pathways 2 70 65 H H H M L L H L L H H L H H H Visualize molecules in 3D space and understand the CLO-4 : 2 70 70 H L H H H L M L L H H L H H H arrangements of different atoms around a carbon center Know how carbonyl compounds cab ne utilized in organic CLO-5 : 2 80 70 L H L M L H H L L H H L H H H transformation Design reaction scheme for the synthesis of a chiral CLO-6 : 2 75 70 H H H H H H H H H H H H H H H compound

Duration 12 12 12 12 12 (hour) Aromaticity, anti- conformational SN1, SN2, SNi and E2, E1, E1cb and Introduction to carbonyl SLO-1 aromaticity and Non analysis: acyclic NGP, E2C mechanisms compounds aromatic compounds system S-1 nucleophilic conformational Hückel’s rule of substitutions at allylic, Nucleophilic addition to SLO-2 analysis: acyclic stereochemistry aromaticity aliphatic and vinyl carbonyl compounds system carbons effect of substrate, Hoffmann and stereochemistry of SLO-1 homo-aromaticity cyclic systems nucleophile, leaving Saytzeff rules nucleophilic additions group, and medium, S-2 neutral and charged effect of substrate, aromatic systems (3, 4, stereochemistry, base, leaving group Cram's rule, Felkin-Anh SLO-2 cyclic systems 5, and 7- membered ambident nucleophiles and medium, model ring systems) pyrolytic eliminations Aromatic electrophilic effect of annulenes and fused substitution, Chugaev reaction, SLO-1 conformation on chemistry of imines rings systems mechanism and Cope elimination reactivity S-3 reactivity heteroannulenes, effect of selectivity and Bamford-Stevens enolates, keto-enol SLO-2 aromaticity of conformation on orientation, the effect of reaction, Sandmeyer tautomerism heterocycles reactivity leaving group reaction SLO-1 S-4 Tutorial Tutorial Tutorial Tutorial Tutorial SLO-2 Types of mechanisms, elements of nitration, nitrosation Addition reactions to condensation reactions SLO-1 transition states and symmetry and diazonium coupling double bonds of carbonyl compounds intermediates aldol condensations S-5 sulphonation, (acid and base thermodynamic and SLO-2 chirality chlorination, triple bonds catalyzed aldol kinetic requirements, bromination condensation, crossed aldol condensation Hammond postulate, molecules with electrophilic, Claisen-Schmidt S-6 SLO-1 Curtin-Hammett more than one Friedel-Crafts alkylation nucleophilic condensation, directed principle, methods of chiral center additions aldol condensations

7 M.Sc.Organic Chemistry Duration 12 12 12 12 12 (hour) determining mechanisms free radical Mukaiyama aldol projection formulae (i) Friedel-Crafts SLO-2 isotopic effects, additions, orientation condensation, Claisen Fischer (ii) Sawhorse acylation, arylation and reactivity ester condensation Hammett equation and Dieckmann reaction, aromatic nucleophilic linear free energy (iii) Newman (iv) stereochemistry of Stobbe SLO-1 substitutions: SNAr, relationship (sigma-rho) Flying Wedge addition reactions condensations,Acyloin SN1 relationship condensation S-7 Knoevenagel condensations, 1,4- Taft equation and its threo and erythro Ring opening of SLO-2 benzyne mechanisms conjugate additions application isomers cyclopropanes (Michael addition), Robinson annulation SLO-1 S-8 Tutorial Tutorial Tutorial Tutorial Tutorial SLO-2 Addition of hydrogen Reaction intermediates: Sommelet-Hauser, Von methods of halides Wittig reactions, SLO-1 Generation, structure, Richter and Smiles resolution (Markownikov’s rule) Mannich reactions stability, and reactivity rearrangement and bromine S-9 specific rotation, halohydrin formation, nucleophilic addition to optical purity and Bucherer and SLO-2 carbocations hydroboration (anti- isocyanates and enantiomeric Rosenmund reactions Markownikov’s rule) isothiocyanates excess enantiotopic and aliphatic substitution diastereotopic hydrozirconation, SLO-1 carbanions mechanisms, SE2, SEi esterification reactions atoms, groups and iodolactonization and SE1 faces S-10 addition-elimination and enantiotopic and cyclic mechanisms, diastereotopic bromolactonization, SLO-2 free radicals halogenations of ester hydrolysis atoms, groups and oxymercuration ketones, aldehydes and faces carboxylic acids hydrogenation reactions stereospecific and aliphatic diazonium (hydrogenation of Mcmurry coupling, SLO-1 carbenes, nitrenes stereoselective coupling, sulphonation, C=C double bonds, Tabbe reagent reactions sulphenylation, triple bonds, and S-11 aromatic rings) acylation, Stork optical activity in the enamines, carbene and Pinacol Coupling benzyne, non-classical SLO-2 absence of chiral nitrene insertions, Koch reaction Reaction, haloform carbocations carbon Kolbe-Schmidt reaction. reaction. SLO-1 S-12 Tutorial Tutorial Tutorial Tutorial Tutorial SLO-2

1. M. B. Smith and J. March, March’s Advance Organic Chemistry, 6th Ed., John Wiley and Sons, Inc. 2. J. Clayden, N. Greeves, and S. Warren, Organic Chemistry 2nd Ed., Oxford. 3. J. McMurry, Organic Chemistry 5th Ed., Thomson. Learning 4. T. W. G. Solomons and C. B. Fryhle, Organic Chemistry 10th Ed.,John Wiley and Sons, Inc. Resources 5. I. L. Finar and A. L. Finar, Organic Chemistry Vol. 2, Addison-Wesley. 6. D. N. Nasipuri, Stereochemistry of Organic Compounds: Principles & Applications South Asia Books.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

8 M.Sc.Organic Chemistry

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Experts from Industry Expert from Higher Technical Institutions Internal Experts 1. Prof. G. Sekar, Department of Chemistry, IIT Madras Dr. Susnata Pramanik, SRMIST Email: [email protected] Dr. Ravikiran Allada, Head R&D, Analytical,

Novugen Pharma, Malaysia 2. Dr. Kanishka Biswas, Jawaharlal Nehru Email: [email protected] Centre for Advanced Scientific Research Dr. Anjan Bedi, SRMIST (JNCASR), Bengaluru Email: [email protected]

9 M.Sc.Organic Chemistry

Course Course Chemical Bonding, Molecular Geometry and Course L T P C PCY21D01T D Discipline Elective Course Code Name Group Theory Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

Recite the types of bonds and illustrate the structure of CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 crystals Solve the radius ratio of the crystals, enthalpy of CLR-2 : formation of ionic compounds and Identify the various crystal defects Summarize the molecular geometry, structure of covalent CLR-3 : compounds Analyze and differentiate the various weak chemical CLR-4 : forces and bonding in metals

Discuss the acidity and basicity of acids and bases based

CLR-5 :

on various concepts

Explore the mathematical calculation based on group

CLR-6 :

theory and find its application in chemistry

Reasoning

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life Define the types of bonds and draws the structures of CLO-1 : 2 75 60 H H H L H H M H H - H H H H H crystals Calculate the radius ratio of the crystal and enthalpy of CLO-2 : 2 80 70 H H L H L L H L L H H L H H H formation of ionic compounds Explain the molecular topologies of covalent compounds CLO-3 : 2 70 65 H H H M L L H L L H H L H H H and illustrate the MOT Relate the weak chemical bonding forces in predicting the CLO-4 : 2 70 70 H L H H H L M L L H H L H H H properties of compounds and metals CLO-5 : Distinguish the acidity and basicity of acids and bases 2 80 70 L H L M L H H L L H H L H H H Identify the molecular vibrations and chirality in CLO-6 : 2 75 70 H H H H H H H H H H H H H H H compounds using group theory

Duration 12 12 12 12 12 (hour) Chemical bond, covalent character in ionic orbital mixing, proton transfer equilibria under SLO-1 types of bonds, ionic compounds, polarization heteronuclear diatomic Symmetry elements aqueous conditions bond and molecules Fajan’s rules, effects of polar bonds, ionic S-1 polarization, solubility, compounds, and properties of ionic proton transfer equilibria under SLO-2 melting points and thermal molecular orbitals, Symmetry elements compounds aqueous conditions stability of typical ionic molecular orbitals of compounds polyatomic molecules factors favoring the non-aqueous solvents and Crystal defects, Schottky SLO-1 formation of ionic Vander Waals forces acid-base strength Symmetry operations defects compounds S-2 ionization potential, non-aqueous solvents and SLO-2 electron affinity and controlled valency, F-center inclusion compounds acid-base strength Symmetry operations electronegativity packing of ions in Frenkel defect, non- Layer, channel periodic trends in aqua acid SLO-1 point groups crystals and stoichiometric structures strength, S-3 cage structures (gas crystal structures, interstitial and electron SLO-2 hydrates and oxoacids, anhydrous oxides, point groups ccp, hcp, bcc, fcc deficient compounds. clathrates) SLO-1 Tutorial session Tutorial session Tutorial session Tutorial session Tutorial session S-4 SLO-2 Tutorial session Tutorial session Tutorial session Tutorial session Tutorial session Hydrogen bonding: groups and classes Molecular topologies: Bronsted-Lowry acidity of S-5 SLO-1 radius ratio and types of symmetry shared and lone pairs and aqueous cations, operations

10 M.Sc.Organic Chemistry Duration 12 12 12 12 12 (hour) groups and classes structure of ionic Hydrogen bonding: Bronsted-Lowry acidity of SLO-2 Lewis structures of symmetry lattices types aqueous cations, operations geometrical method non-conventional Lewis acid- base concept and non-degenerate SLO-1 of computing radius isoelectronic and hydrogen bonding, frontier orbitals, representations, ratios S-6 relation between associated molecules, examples of Lewis acids and non-degenerate SLO-2 radius ratio and isolobal relationships, molecular self- bases, representations, coordination number assembly hybridization and geometry supramolecular quantification of Lewis basicity, Great Orthogonality SLO-1 Stoichiometry and architectures formed by theorem weak chemical forces. S-7 supramolecular inductive and steric effects on Great Orthogonality SLO-2 crystal structures hybridization and geometry architectures formed by Lewis acidity and basicity, theorem weak chemical forces. SLO-1 Tutorial session Tutorial session Tutorial session Tutorial session Tutorial session S-8 SLO-2 Tutorial session Tutorial session Tutorial session Tutorial session Tutorial session Lattice energy: Bonding in metals: Construction of SLO-1 definition, Born- VSEPR model packing of atoms in frustrated Lewis pairs character table Lande equation metals, S-9 Bonding in metals: factors affecting Construction of SLO-2 VSEPR model packing of atoms in frustrated Lewis pairs lattice energy character table metals, Born-Haber cycle molecular orbital theory, band theory of metals reduction formula, SLO-1 linear combination of atomic and metallic properties hard and soft acids and bases, character of matrices orbitals S-10 enthalpy of insulators and degenerate bonding, antibonding formation of ionic semiconductors hard and soft acids and bases, representations SLO-2 andnon-bonding molecular compounds and orbitals stability MOs of homonuclear thermodynamic acidity applications to calculation of ionic diatomic molecules Bronsted-Lowry parameters, superacid and molecular vibrations SLO-1 radius, Pauling’s concept superbase. (IR and Raman method and activity) and chirality. S-11 Linde’s method, MOs of homonuclear thermodynamic acidity applications to effective nuclear diatomic molecules Bronsted-Lowry parameters, superacid and molecular vibrations SLO-2 charge, Slater’s concept superbase. (IR and Raman rule, activity) and chirality. SLO-1 Tutorial session Tutorial session Tutorial session Tutorial session Tutorial session S-12 SLO-2 Tutorial session Tutorial session Tutorial session Tutorial session Tutorial session

1. D. F.Shriver, P. W.Atkins and C. H. Langford, Inorganic Chemistry, 3rdEd., Oxford University Press, London, 2001 2. J. E.Huheey, E. A.Keiter and R. L. Keiter, Inorganic Chemistry, 4thEd., Harper and Row, NewYork, 1983 Learning 3. A.Vincent,Molecular Symmetry and Group Theory. A Programmed Introduction to Chemical Applications, JohnWiley& Sons Ltd, Resources 1977. 4. F. Albert Cotton, Chemical Applications of Group Theory, 2ndEd., John Wiley & Sons, 1971.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

11 M.Sc.Organic Chemistry

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Expert from Higher Technical Experts from Industry Internal Experts Institutions 1. Prof. G. Sekar, IIT Madras, Dr. Ravikiran Allada, Head R&D, Analytical, [email protected] Dr. J. Arockia Selvi J Novugen Pharma, Malaysia Email: [email protected] 2. Prof. Vivek Polshettiwar, TIFR Mumbai, [email protected] 2. Dr. M. Arthanareeswari, SRMIST

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12 M.Sc.Organic Chemistry Course Course Course L T P C PCY21D02T Materials Chemistry D Discipline Elective Courses Code Name Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

CLR-1 : Introduce the science of materials chemistry 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Deepen the knowledge on crystalline materials with a CLR-2 : focus on their synthesis methods Improve the understanding of amorphous, electronic CLR-3 : materials and their applications Understand the fundamentals of nanomaterials and their CLR-4 : applications Gain knowledge about mechanical, magnetic and electrical

CLR-5 : properties of materials along with their technological

relevance

Enlighten with basic principles of various analytical

CLR-6 :

techniques for characterization of materials

Course

Learning

1 2

- -

At the end of this course, learners will be able to: -

Directed Learning Directed Skills

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICT Learning Long Life Understand different types of materials, their properties, CLO-1 : 2 75 60 H H H L H H M H H L H H H H H characterization and applications Well aware of various chemical, physical methods of CLO-2 : 2 80 70 H H L H L L H L L H H L H H H crystalline materials synthesis Gain knowledge about amorphous materials, polymer CLO-3 : 2 70 65 H H H M L L H L L H H L H H H materials and band theory of solids Acquaint with the fundamental concepts of nanomaterials CLO-4 : 2 70 70 H L H H H L M L L H H L H H H and their importance Familiar with the mechanical, magnetic and electrical CLO-5 : 2 80 70 L H L M L H H L L H H L H H H properties of the materials and their technological relevance Identify the suitable analytical techniques and perform the CLO-6 : 2 75 70 H H H H H H H H H H H H H H H characterization of materials

Duration (hour) 12 12 12 12 12 Spectroscopic Crystalline materials: Amorphous solids: Nanomaterials: Mechanical properties: SLO-1 methods: introduction Introduction Introduction introduction Introduction A comparison of S-1 crystalline and Various mechanical Spectroscopic Crystalline materials: Examples of a variety SLO-2 amorphous materials in properties and their methods: introduction of nanomaterials terms of properties and importance Introduction applications UV-Vis: Fundamentals of Quantum Instrumentation, SLO-1 oxide glasses ductile fracture lattice confinement basic working S-2 principles quantum Examples in SLO-2 Unit cell chalcogenide glasses brittle fracture nanostructures Analysis IR: surface energy of Instrumentation, SLO-1 Atomic coordinates amorphous carbon toughness nanomaterials basic working S-3 principles surface diamond, graphite, Examples in SLO-2 Bravias lattices area of Impact testing alkaline graphite Analysis nanomaterials SLO-1 S-4 Tutorial Tutorial Tutorial Tutorial Tutorial SLO-2 X-ray diffraction: polymer compounds: fabrication methods magnetic properties of Instrumentation, S-5 SLO-1 Point defects Introduction of nanomaterials materials: introduction basic working principles

13 M.Sc.Organic Chemistry Duration (hour) 12 12 12 12 12 Top down and Examples and Examples in SLO-2 Line defects: line bottom up Para magnetic properties applications Analysis approaches Electron microscopy: SEM, Classification of SLO-1 Surface defects band theory of solids Ferro magnetic properties Instrumentation, nanomaterials S-6 basic working principles 0D,1D and 2D anti-ferro magnetic Examples in SLO-2 Bulk defects band theory of solids nanomaterials properties Analysis synthetic Electron approaches for microscopy: TEM, 0D nanomaterials SLO-1 crystalline functional Insulators Ferri magnetic properties Instrumentation, examples materials: Chemical basic working methods principles S-7 synthetic approaches for Technological relevance of 0D nanomaterials Examples in SLO-2 crystalline functional semiconductors magnetic properties of applications Analysis materials: Chemical materials with few examples methods SLO-1 S-8 Tutorial Tutorial Tutorial Tutorial Tutorial SLO-2 synthetic XPS: approaches for Thermoelectric properties: Instrumentation, SLO-1 crystalline functional Super conductivity porous materials Introduction basic working materials: Chemical principles methods S9 synthetic approaches for optical properties of Examples in SLO-2 crystalline functional soft materials dielectric properties materials Analysis materials: Chemical methods synthetic Probe Analysis, Band gap of approaches for AFM: materials and its SLO-1 crystalline functional amorphous materials Piezoelectric properties Instrumentation, correlation with materials: Physical basic working optical properties methods principles S-10 synthetic approaches for Concept of doping luminescent Examples in SLO-2 crystalline functional and different types of Pyroelectric properties materials Analysis materials: Physical dopant materials methods synthetic Discussion on a few approaches for Effect of doping on examples of Peculiar examples SLO-1 crystalline functional optical properties of technologies ferroelectric effect of materials materials: Physical materials developed using characterization methods nanomaterials S-11 Discussion on a few synthetic approaches Devices based on examples of Technological relevance of Peculiar examples for crystalline SLO-2 optical properties of technologies electrical properties of of materials functional materials: materials developed using materials with few examples characterization Physical methods nanomaterials SLO-1 S-12 Tutorial Tutorial Tutorial Tutorial Tutorial SLO-2

1. A. R. West, Basic Solid State Chemistry, 2nd Ed., John Wiley &Sons Ltd., 1999 2. K. J. Klabunde, Nanoscale materials in Chemistry, Wiley Interscience, New York, 2001 Learning 3. C. Giacovazzo, Fundamentals of Crystallography, Oxford University Press, 2002. Resources 4. W. D. Callister and D. G. Rethwisch, Materials Science and Engineering: An Introduction,9th Ed., Wiley, 2013. 5. D. J. Ward, Materials Science, Lerner Classroom, 2008

14 M.Sc.Organic Chemistry Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Expert from Higher Technical Experts from Industry Internal Experts Institutions 1. Prof. G. Sekar, IIT Madras, Dr. Ravikiran Allada, Head R&D, Analytical, [email protected] Dr. Srinivasarao Kancharla Novugen Pharma, Malaysia Email: [email protected] 2. Prof. Vivek Polshettiwar, TIFR Mumbai, [email protected] Dr. M. Arthanareeswari

======

15 M.Sc.Organic Chemistry

Course Course Course L T P C PCY21D03T Advanced Polymer Science D Discipline Elective Courses Code Name Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

CLR-1 : gain exposure to the field of advanced polymer science 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 understanding the structural requirements to exhibit liquid CLR-2 : crystallinity and properties of different types of LCPs get knowledge on synthesis, properties and applications CLR-3 : of different types of ionic polymers learn this course will develop skills on synthesis of CLR-4 : conducting polymers and understand the significance and applications of conducting polymers. enrich the knowledge on biopolymers and biodegradable CLR-5 : polymers and the basic aspects of polymer nanocomposites and their applications.

correlate the structure and property of smart polymeric

materials for advanced drug delivery, tissue engineering,

CLR-6 :

medical devices, bioseparation, optical data storage,

packaging and textile applications

Learning

Course

Learning 1

- -

At the end of this course, learners will be able to: - Directed Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life CLO-1 : develop knowledge on advanced polymer science 2 75 60 H H H L H H M H H L H H H H H learn about main-chain and side chain LCPs and their CLO-2 : 2 80 70 H H L H L L H L L H H L H H H properties get knowledge on ionic polymers for the preparation of CLO-3 : 2 70 65 H H H M L L H L L H H L H H H polyelectrolyte complexes. fabricate a device using suitable conducting polymeric CLO-4 : material for rechargeable batteries, sensors, 2 70 70 H L H H H L M L L H H L H H H electrochemical actuators and electroluminescent. identify the polymers for biomedical application and CLO-5 : 2 80 70 L H L M L H H L L H H L H H H prepare nanocomposites for high temperature application. design new smart polymeric material for advanced drug delivery, tissue engineering, medical devices, CLO-6 : 2 75 70 H H H H H H H H H H H H H H H bioseparation, optical data storage, packaging and textile applications.

Duration 12 12 12 12 12 (hour) Introduction to SLO- Introduction to Synthesis of ionic Introduction to Synthesis of conducting polymers biopolymers and 1 LCPs polymers smart polymers biodegradable polymers S-1 Structural Introduction to temperature- SLO- requirements to Synthesis of ionic Synthesis of conducting polymers biopolymers and responsive 2 exhibit liquid polymers biodegradable polymers polymers crystallinity Main-chain LCPs: SLO- properties of ionic properties of conducting pH-responsive thermotropic & polymers in medicines 1 polymers polymers polymers lyotropic liquid S-2 crystals Various phases, SLO- applications of ionic drug carriers & controlled photoresponsive study of phase polyacetylene 2 polymers drug release polymers transitions Magnetically & properties of LC biodegradable SLO- Ionic crosslinking enzyme main-chain poly(p-phenylene vinylene) (PPV) polymers:starch-based 1 responsive polymers polymers, S-3 polymers application of LC SLO- poly(glycolic acid) (PGA) shape memory main-chain ion-exchange poly(p-phenylene vinylene) (PPV) 2 & polylactic acid (PLA) polymers polymers

16 M.Sc.Organic Chemistry Duration 12 12 12 12 12 (hour) SLO- Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session 1 S-4 SLO- Question answer Question answer Question Question answer Session Question answer Session 2 Session Session answer Session polyheterocyclic and SLO- Side-chain LC ionomers based on poly(lactic-co-glycolide) polyaromatic conducting smart hydrogels 1 polymers polyethylene (PLGA) polymers: S-5 SLO- principles of ionomers based on polyaniline polycaprolactone (PCL) smart hydrogels 2 synthesis polyethylene structural Applications of the SLO- features of side- ionomers based on self-healing polypyrrole & polythiophene pharmaceutical polymers: 1 chain LC polystyrene polymers vinyl polymers S-6 polymers properties of SLO- ionomers based on poly(3,4- cellulose ethers & applications of side-chain LC 2 polytetrafluoroethylene ethylenedioxythiophene)(PEDOT) polyesters smart polymers polymers application of silicones, polysaccharides SLO- side-chain LC elastomeric ionomers poly(p-phenylene sulfide) and related polymers drug delivery 1 polymers,

S-7 Polymer nanocomposites: SLO- nematic and tissue aromatic ionomers poly(vinyl carbazole) an overview of 2 cholesteric LCPs engineering nanoparticles SLO- Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session 1 S-8 SLO- Question answer Question answer Question Question answer Session Question answer Session 2 Session Session answer Session SLO- photochromic polymers with integral processing of polypyrene medical devices 1 LCPs, ions: nanomaterials S-9 chiral- SLO- halatotelechelic processing of photochromic polyphenylene medical devices 2 polymers (HTP’s) nanomaterials LCPs polyethyleneimine Applications of conducting SLO- ionogenic LCPs characterization of (PEI) & ion exchange polymers: polymer rechargeable bioseparation 1 & LC elastomers polymer nanomaterials materials batteries S-10 SLO- photomechanical polyelectrolytic properties of polymer optical data sensors 2 LC polymers complexes nanocomposite materials storage polymer nanocomposites packaging & SLO- LC block biological ionic for high-temperature textiles electrochemical actuators 1 copolymers polymers applications. application S-11

SLO- inorganic ionic current status, trends and advancements in LC composites electroluminescent 2 polymers future. smart polymers. SLO- Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session 1 S-12 SLO- Question answer Question answer Question Question answer Session Question answer Session 2 Session Session answer Session

1. X. Wang, Q. Zhou, Liquid Crystalline Polymers. N.J World Scientific: Singapore, 2004. 2. Hendy B.N. Ionic polymers. In: Dyson R.W. (eds) Specialty Polymers. Springer, Boston, MA 1987. 3. Matrin. T. Goosey, Plastics for Electronics, Elsevier Applied Science Publishers, 1985. 4. M.J. Bowden and S.R. Turner, Polymers for High Technology, Electronics and Photonics, American Chemical Society 1987. Learning 5. Terje A. Skotheim, John Reynolds, Conjugated Polymers: Theory, Synthesis, Properties, and Characterization, 3rd Edition, CRC Resources Press, 2006. 6. David Jones, Pharmaceutical Applications of Polymers for Drug Delivery, iSmithers Rapra Publishing, 2004. 7. Biopolymers, edited by Alexander Steinbüchel, Institute of Microbiology, University of Münster, WILEY-VCH, 2004. 8. Joseph H. Koo, Polymer Nanocomposites, Processing, Characterization, and Applications, 2nd Edition,Mc Graw Hill, 2019. 9. Maria Rosa Aguilar Julio San Román, Smart Polymers and Their Applications, 2nd Edition, Woodhead Publishing, 2019.

17 M.Sc.Organic Chemistry

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Experts from Industry Expert from Higher Technical Institutions Internal Experts 1. Prof. G. Sekar, Department of Chemistry, IIT Madras Dr. Ravikiran Allada, Head R&D, Email: [email protected] 1. Dr. Samarendra Maji, SRMIST Analytical, Novugen Pharma, Malaysia 2. Dr. Kanishka Biswas, Jawaharlal Nehru Centre for Email: [email protected] Advanced Scientific Research (JNCASR), Bengaluru 2. Dr. Priyadip Das, SRMIST Email: [email protected]

======

18 M.Sc.Organic Chemistry

Course Course L T P C Course Name Fundamentals of Cheminformatics S . Skill Enhancement Courses Code PCY21S01J Category 1 0 2 2

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

enable them to learn the principles of computer aided CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 chemical information tools explore the data base search for the molecules and its CLR-2 : access for the chemical reactions Explore about IUPAC names, design of molecules at CLR-3 : different platforms. Develop strategies of drug design and target oriented CLR-4 : receptor interaction study Strengthen the chemicals tools with computer aided CLR-5 :

learning with pharmacopeia study

Stages of drug discovery and current state of art in the

CLR-6 : drug design process

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life Understand the basic principles of computer aided drug CLO-1 : 2 75 60 H H H L H H M H H L H H H H H design through chemistry approaches. CLO-2 : Gain knowledge about the chemical databases 2 80 70 H H L H L L H L L H H L H H H Understand the basic principles of design of molecules as CLO-3 : 2 70 65 H H H M L L H L L H H L H H H chemical library Acquaint the student with the fundamental concepts of CLO-4 : 2 70 70 H L H H H L M L L H H L H H H drug discovery and different stages Gain knowledge about the computer assisted synthesis CLO-5 : 2 80 70 L H L M L H H L L H H L H H H and structure based library Understand the principles of modeling tools and concepts CLO-6 : 2 75 70 H H H H H H H H H H H H H H H in molecular modeling and pharmacokinetics

Duration 9 9 9 9 9 (hour) Chem Draw, Sequence, 2D, Analysis of CCDC Combinatorial library design Application of SLO-1 Gaussian, Marvin 3D structure structures and parameters compound selection cheminformatics Sketch S-1 QSPR Drug Types of Study with different combinatorial optimization design and Target SLO-2 chemical ORTEP, Chimera examples and analysis approach identification and representation Validation SLO-1 Practical: Practical: Practical : Practical: Practical: S2 Design of 2D and CCDC practice with Chem bio draw with Molecular SLO-2 PyMol software 3D structures examples examples modeling SLO-1 Practical: Practical: Practical: Practical : Practical: Molecular S3 Developing data CCDC practice with Chem bio draw with PyMol software with SLO-2 modeling with bases examples examples examples case study examples RasMol, PyMol, graphical Crystallographic Open lead finding and SLO-1 Molecular Modeling Descriptor Analysis representation Database COD optimization Tools S-4 Structural Homology Chemical data Structure design and Modeling Tools Examples with SLO-2 Modeling toxicity management search parameters Docking Tools and case study Screening Tools SLO-1 Practical: Practical: Practical: CIF creation and Practical: Practical: S5 Open data base creation Gaussian/Gauss view SLO-2 analysis with Marvin Sketch software QSPR and docking of CIFs software with examples examples SLO-1 Practical:Open data Practical : Practical: Practical: S6 Practical: base creation of CIFs, Gaussian/Gauss view Marvin Sketch software with QSPR and docking SLO-2 ORTEP software with examples examples with examples

19 M.Sc.Organic Chemistry CIF creation and analysis with examples Pharmacophore- Chemical Computer Assisted Protein Data Bank and Concepts in Based Drug SLO-1 markup Synthesis and structure design of PDB structure Molecular Modeling Design and model languages based library drugs S-7 IUCr Molecular Mechanics Development of drug, drug PDB Ligand Explorer Structure-Based Crystallographic Derivatives of life cycle drug development SLO-2 Chemspider, Other Data Drug design with Information molecular mechanics time lines and stages of drug Bases examples Framework and Energy function discovery Practical: SLO-1 Graphical view of Practical: Practical: S-8 Marvin Sketch software with Practical: molecules PDB data base RasMol software SLO-2 examples Docking of durgs SLO-1 Practical: Practical: Practical: Graphical view of Ras Mol software Practical: S-9 SLO-2 Exploring Chemspider Marvin Sketch software with molecules with examples case Docking with and its tools examples SLO-2 study examples

1. Andrew R. Leach & Valerie J. Gillet, “An Introduction to Cheminformatics”, Revised Edition, Springer Publication, 2007. 2. Johann Gasteiger, Dr. Thomas Engel, “Cheminformatics”, Wiley-VCH Press, 2003. Learning 3. Jurgen Bajorath, “Cheminformatics: Concepts, Methods and Tools for Drug Discovery”, Humana Press, 2004. Resources 4. Tudor. L.Oprea, “Cheminformatics in Drug Discovery”, Wiley-VCH Press, 2005. 5. Silverman, Richard B., and Mark W. Holladay. The organic chemistry of drug design and drug action. Academic press, 2014. 6. Bajorath, Jurgen. Chemoinformatics for Drug Discovery. John Wiley & Sons, 2013.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% 30% 30% 30% 30% 30% 30% 30% 30% 30% Understand Apply Level 2 40% 40% 50% 50% 50% 50% 50% 50% 50% 50% Analyze Evaluate Level 3 30% 30% 20% 20% 20% 20% 20% 20% 20% 20% Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Experts from Industry Expert from Higher Technical Institutions Internal Experts 1. Prof. G. Sekar, Department of Chemistry, IIT Madras 1. Dr. Ravikiran Allada, Head R&D, Email: [email protected] 1. Dr. Venkatramaiah Nutalapati Analytical, Novugen Pharma, Malaysia 2. Dr. Kanishka Biswas, Jawaharlal Nehru Centre for Email: [email protected] Advanced Scientific Research (JNCASR), Bengaluru 2. Dr Renjith Sasimohanan Pillai Email: [email protected]

======

20 M.Sc.Organic Chemistry

Course Course Course L T P C PCD21AE1T Professional Skills and Problem Solving A Ability Enhancement Course Code Name Category 1 0 0 1

Pre-requisite Co-requisite Progressive Nil Nil Nil Courses Courses Courses Course Offering Career Development Centre Nil Department

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR): CLR-1: utilise success habits to enhance professionalism 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 CLR-2: enable to solve problems and to crack competitive exams. understand and master the mathematical concepts to CLR-3:

solve types of problem

CLR-4: Identify a logically sound and well-reasoned argument

CLR-5: expertise in communication and problem-solving skills

CLR-6: develop problem solving skills with appropriate strategies

Course

2 3

Learning 1

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

(CLO):

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life PSO PSO PSO CLO-1: identify success habits and inculcate professional skills 2 80 75 H H H H H H H H H H M H H H H grasp the approaches and strategies to solve problems with CLO-2: 2 80 70 H H H H H H H H H H M H H H H speed and accuracy CLO-3: collectively solve problems in teams and groups 2 75 70 H H H H H H H H M H M H H H H CLO-4: construe and solve an argument through critical thinking 2 80 75 H H H H H H H H H H M H H H H CLO-5: acquire communication and problemsolving skills 2 80 70 H H H H H H H H H H M H H H H CLO-6: apply problem solving techniques and skills 2 80 75 H H H H H H H H H H M H H H H

Duration 3 3 3 3 3 (hour) Creative problem solving Personal profiling Case study analysis SLO-1 method Emotional Intelligence Communication skills

S-1 USP& Personal Case study analysis Personal & social SLO-2 Communication skills branding Techniques competence Assumption and Conclusion and paradox Main idea and structure of Tone and Style of a SLO-1 strengthening of an Weakening and Inference of an argument a passage passage argument of an argument S-2 Assumption and Weakening and Inference Conclusion and paradox Main idea and structure of Tone and Style of a SLO-2 strengthening of an of an argument of an argument a passage passage argument Arithmetic: Simple SLO-1 Profit, Loss & Discount Average Percentage Mixtures & alligation equations Equation 1 and S-3 SLO-2 Interest calculation Average Percentage Mixtures & alligation equation 2

3.Manhatten Prep - GRE Reading Comprehension and 1.Arun Sharma-Quantitative aptitude for CAT, Tata McGraw Hill Learning Essays 2.Dinesh Khattar-The Pearson Guide to QUANTITATIVE APTITUDE Resources 4. Seven habits of highly effective people- Steven Covey for competitive examinations. 5. Manhattan Prep – Critical Reasoning Skills and Techniques

Learning Assessment Bloom’s Continuous Learning Assessment (50% weightage) Final Examination (50% Level of CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# weightage) Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember - - - - Level 1 30 % - 30 % 30 % 30 % 30 % Understand Apply - - - - - Level 2 40 % 40 % 40 % 40 % 40 % Analyze Evaluate - - - - - Level 3 30 % 30 % 30 % 30 % 30 % Create Total 100 % 100 % 100 % 100 % 100 %

21 M.Sc.Organic Chemistry

# CLA – 4 can be from any combination of these: Assignments, Seminars, Scientific Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications etc.,

Course Designers Experts from Industry Internal Experts 1.Mr Ajay Zenne, Career Launcher, Mr. P Priyanand, SRMIST [email protected] Mrs. Kavitha Srisarann, SRMIST 2. Mr.Pratap Iyer, Study Abroad Mentors, Mumbai, Mr. Harinarayana Rao, SRMIST [email protected] Dr. A Clement, SRMIST

======

22 M.Sc.Organic Chemistry SEMESTER II

Course Course Spectroscopy and Applications in Organic Course L T P C POC21201T C Professional Core Course Code Name chemistry Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

gain knowledge about basic spectroscopic techniques CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 used in organic chemistry understand the fundamental and importance of UV and CLR-2 : FTIR spectroscopy understand the fundamental and importance of Mass CLR-3 : and NMR spectroscopy provide basic understanding about the concepts involved CLR-4 : in various chromatographic techniques

give insight about the advantages and limitations of

CLR-5 :

spectroscopic techniques

nce

provide basic understanding about the concepts involved

CLR-6 :

in various chromatographic techniques

Course

Thinking (Bloom) Thinking

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Compete Multicultural ICTSkills Learning Long Life describe the physical and chemical changes that occur at CLO-1 : 2 75 60 H H H L H H M H H L H H H H H the molecular level during a MS, IR, or NMR experiment. identify different functional groups present in organic CLO-2 : 2 80 70 H H H H L H L H M H H M H H H compounds using IR spectra. explain common terms in NMR spectroscopy such as CLO-3 : chemical shift, coupling constant, and anisotropy, and 2 80 70 H H H M L H L H M H H M H H H describe how they are affected by molecular structure. analyze and interpret 1D- 1H and 13C NMR as well as 2D CLO-4 : NMR to determine chemical structure of organic 2 70 65 H H H M L H H L L H H L H H H compounds. CLO-5 : explain major fragmentation patterns of organic 2 80 70 L H L M L H H L L H H L H H H compounds using mass spectra CLO-6 : integrate all spectral data (MS, IR, and/or NMR) of a compound to elucidate the structure of an organic 2 75 70 H H H H H H H H H H H H H H H molecule.

Duration 12 12 12 12 12 (hour) SEPARATION Infrared spectroscopy: NMR TECHNIQUES: SLO- Ultraviolet spectroscopy: Units of frequency wave Mass spectroscopy: spectroscopy: Solvent extraction 1 Introduction length and wave number, Basic Principles Basics and Ion exchange molecular vibrations S-1 techniques Infrared spectroscopy: Larmor Interaction of SLO- Units of frequency wave Mass spectroscopy: precession, principles and electromagnetic radiation 2 length and wave number, Basic Principles resonance applications with matter molecular vibrations absorption factors influencing magnetic fields, SLO- Instrumentation, The Chromatographic Absorption laws vibrational frequencies, shielding and 1 mass spectrometer techniques selection rules chemical shifts S-2 factors influencing Measurement of the SLO- vibrational Instrumentation, The chemical adsorption spectrum, chromophores, 2 frequencies, selection mass spectrometer equivalence chromatography standard works of reference rules relaxation isotope abundances, SLO- processes thin layer S-3 Selection rules The IR spectrometer the molecular ion, 1 Solution state (1H, chromatography metastable ions 13C)

23 M.Sc.Organic Chemistry Duration 12 12 12 12 12 (hour) electronic transitions in relaxation isotope abundances, SLO- organic, and molecules and processes The IR spectrometer the molecular ion, gas chromatography 2 application to structure Solution state (1H, metastable ions. elucidation 13C) Applications of UV spectroscopy to Conjugated Reactions of ions in gas spin-spin coupling high performance SLO- dines, trienes, unsaturated sampling techniques phase – effect of AX, AX2 and AXn liquid 1 carbonyl compounds and isotopes systems chromatography aromatic compounds. S-4 Applications of UV characteristic spectroscopy to Conjugated frequencies of organic Reactions of ions in Paramagnetic high performance SLO- dines, trienes, unsaturated molecules and gas phase – effect of shifts and their liquid 2 carbonyl compounds and interpretation of isotopes applications chromatography aromatic compounds. spectra Woodward -Fieser rules for the calculation of absorption nitrogen rule, SLO- Theory of IR size exclusion maxima (Lamda max) for determination of Instrumentation 1 spectroscopy chromatography dienes and carbonyl molecular formula compounds S-5 Woodward -Fieser rules for the calculation of absorption nitrogen rule, SLO- Theory of IR size exclusion maxima (Lamda max) for determination of Instrumentation 2 spectroscopy chromatography dienes and carbonyl molecular formula compounds chemical shift, calculations of various stretching and fragmentations and chemical shifts of vibration modes for rearrangements - SLO- aliphatic, olefinic, Supercritical fluid Fieser and Kuhn rules diatomic and triatomic metastable ions – 1 alkyne, aromatic, chromatography molecules (both linear fragmentation of hetero aromatic and nonlinear) organic compounds S-6 and carbonyl carbons various stretching and fragmentations and Effects of auxo chromes and vibration modes for rearrangements - SLO- factors affecting Supercritical fluid effects of conjugation on the diatomic and triatomic metastable ions – 2 chemical shifts chromatography absorption maxima molecules (both linear fragmentation of and nonlinear) organic compounds Instrumentation, Different shifts of absorption various ranges of IR various methods of SLO- peaks (Batho chromic, (Near, Mid, Finger ionization (field APT, INEPT, Electrophoresis 1 hypsochromic, print and Far) and their ionization, field DEPT hypochromic) usefulness desorption, FAB, MALDI,) S-7 Instrumentation, Homo nuclear Different shifts of absorption various ranges of IR various methods of (13C13C) and SLO- peaks (Batho chromic, (Near, Mid, Finger ionization (field Hetero nuclear Electrophoresis 2 hypsochromic, print and Far) and their ionization, field (13C1H) coupling hypochromic) usefulness desorption, FAB, constants MALDI,) Thermal methods of Difference in the absorption Instrumentation (Only analysis -thermal SLO- spectra of organic and the sources and different detectors - 2D NMR methods of analysis 1 inorganic compounds and detectors used in magnetic analyzer Techniques and evolution of complexes different regions) analytical data S-8 Thermal methods of Difference in the absorption Instrumentation (Only analysis -thermal SLO- spectra of organic and the sources and different detectors - 2D NMR methods of analysis 2 inorganic compounds and detectors used in magnetic analyzer Techniques and evolution of complexes different regions) analytical data Instrumentation for single ion cyclotron analyzer, General idea sample preparation TGA - principles, SLO- beam and double beam UV Quadrupoule mass about two techniques (Gas, instrumentation and 1 and VISIBLE filter, time of flight dimensional NMR Liquid and solid) applications spectrophotometers (TOF) spectroscopy S-9 Instrumentation for single ion cyclotron analyzer, Correlation sample preparation TGA - principles, SLO- beam and double beam UV Quadrupoule mass spectroscopy techniques (Gas, instrumentation and 2 and VISIBLE filter, time of flight (COSY)-Homo Liquid and solid) applications spectrophotometers (TOF) COSY (1H1H) Rules of fragmentation TOCSY, Hetero DTA - principles, SLO- Applications in organic Qualitative analysis of S-10 of different functional COSY (HMQC, instrumentation and 1 molecule analysis alkanes, alkenes groups HMBC) applications

24 M.Sc.Organic Chemistry Duration 12 12 12 12 12 (hour) Optical rotatory dispersion Rules of fragmentation TOCSY, Hetero DTA - principles, SLO- and circular dichroism: Qualitative analysis of of different functional COSY (HMQC, instrumentation and 2 Phenomena of ORD and alkanes, alkenes groups HMBC) applications CD. Homo and Hetero DSC - principles, SLO- Classification of ORD and Qualitative analysis of factors controlling nuclear 2D instrumentation and 1 CD Curves; carbonyl compounds fragmentation resolved applications spectroscopy S-11 Homo and Hetero SLO- Classification of ORD and Qualitative analysis of factors controlling nuclear 2D Types of errors 2 CD Curves; carbonyl compounds fragmentation resolved spectroscopy NOESY and 2D- Organic functional Cotton effect curves and INADEQUATE evaluation of SLO- group identification their application to HRMS experiments and analytical data 1 through IR stereochemical problems their applications. statistical methods. spectroscopy S-12 Organic functional NOESY and 2D- The Octant rule and its evaluation of SLO- group identification INADEQUATE application to alicyclic ketones. HRMS analytical data 2 through IR experiments and statistical methods. spectroscopy their applications.

1. Fundamentals of Molecular Spectroscopy. C. N. Banwell and E. M. McCash, Tata McGraw Hill publishing 2. Introduction to Spectroscopy by Donald L. Pavia, Gary M. Lampman, George S. Kriz, James R. Vyvyan, Fourth Ed., Brooks/Cole Thomson Learning 2009. 3. R. M. Silverstein, F. X. Webster, D. J. Kiemle, Spectrometric identification of organic compounds, 7th edition, John Wiley, 2005. Learning 4. Organic Spectroscopy, W. Kemp, 3rd edition, Macmillan, 2011. Resources 5. D. H. Williams and I. Fleming, Spectroscopic Methods in Organic Chemistry, McGraw Hill, 6th edition 2007. 6. Spectroscopic Methods in Organic Chemistry. Fourth Edition D.M. Williams and I. Fleming Tata - McGraw Hill, New Delhi, 1990. For all spectral methods except ORD and CD and ESR. 7. Organic Spectroscopy, Second Edition, W. Kemp, ELBS Macmillan, 1987 for ORD and CD.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru Centre

for Advanced Scientific Research (JNCASR), Dr. Priyadip Das, SRMIST Bengaluru Email: [email protected]

======

25 M.Sc.Organic Chemistry

Course Course Course L T P C POC21202T Transformations in Organic Chemistry C Professional Core Course Code Name Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

CLR-1 : Introduce to the chemistry of the organoboron/silicon/tin 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Understand various C-C bond forming reactions and CLR-2 : alkene chemistry CLR-3 : Gain knowledge of transition metal catalysis explore oxidation/reductions reactions as elegant CLR-4 : synthetic methods

CLR-5 : Introduce to the reactivity radical

Introduce to the chemistry and application of the

CLR-6 : polycyclic aromatic hydrocarbons (also heteroatom

based)

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life CLO-1 : Understand boron, silicon and tin chemistry 2 75 60 H H H L H H M H H L H H H H H CLO-2 : Comprehend alkene chemistry 2 80 70 H H L H L L H L L H H L H H H CLO-3 : Understand transition metal based C-C bond formation 2 70 65 H H H M L L H L L H H L H H H Comprehend Oxidation and reduction methods in CLO-4 : 2 70 70 H L H H H L M L L H H L H H H chemistry CLO-5 : Understand reactivity and usefulness of radicals 2 80 70 L H L M L H H L L H H L H H H Know polyaromatic hydrocarbons and heteroatom based CLO-6 : 2 75 70 H H H H H H H H H H H H H H H polyaromatic hydrocarbons and their applications

Duration 12 12 12 12 12 (hour) Metal-based and Catalytic hydrogenation Origin of fused Grignard reagents, non-metal based (Heterogeneous: Introduction, natural aromatics SLO- cuprates (Gilman oxidations of (a) palladium/platinum/rhodium/nickel, sources, radical hydrocarbons, 1 reagent)and other alcohols to etc.) reactions in body naphthalene, conjugate reactions S- carbonyls anthracene, 1 Metal-based and Grignard reagents, Catalytic hydrogenation non-metal based Introduction, natural acenaphthene, SLO- cuprates (Gilman (Heterogeneous: oxidations of (a) sources, radical phenanthrene, 2 reagent)and other palladium/platinum/rhodium/nickel, alcohols to reactions in body pyrene conjugate reactions etc.) carbonyls Olefination and aromatic Corey-Kim Catalytic hydrogenation SLO- cyclopropanation Reactions involving free stabilization, oxidation, Dess- (Homogeneous: Wilkinson). 1 reaction, Bayliss Hillman radical intermediates electron Martin oxidation Noyori asymmetric hydrogenation) S- reaction delocalization 2 Olefination and aromatic Corey-Kim Catalytic hydrogenation SLO- cyclopropanation Reactions involving free stabilization, oxidation, Dess- (Homogeneous: Wilkinson). 2 reaction, Bayliss Hillman radical intermediates electron Martin oxidation Noyori asymmetric hydrogenation) reaction delocalization Organoboron Swern oxidation, SLO- compounds, synthesis of phenols (Fremy’s Metal based reductions using Generation of radical synthesis 1 organoboranes, salt, silver Li/Na/Ca in liquid ammonia intermediates S- carbonylation carbonate) 3 Organoboron Swern oxidation, SLO- compounds, synthesis of phenols (Fremy’s Metal based reductions using Generation of radical synthesis 2 organoboranes, salt, silver Li/Na/Ca in liquid ammonia intermediates carbonylation carbonate) SLO- S- 1 Tutorial Tutorial Tutorial Tutorial Tutorial 4 SLO- 2 other one-carbon alkenes to S- SLO- homologation reactions, epoxides Metal based reductions using nucleophilic and reactivity 5 1 homologation via α-halo (peroxides/per sodium, magnesium, zinc electrophilic radicals enolates, acids based)

26 M.Sc.Organic Chemistry Sharpless asymmetric epoxidation, Introduction to other one-carbon asymmetric SLO- homologation reactions, synthesis , Birch reduction, dehalogenation nucleophilic and reactivity 2 homologation via α-halo Sharpless and deoxygenation electrophilic radicals enolates, asymmetric epoxidation heteroatomic polycyclic stereoselective alkene Hydride transfer reagents from mechanisms of radical hydrocarbons, SLO- synthesis, nucleophilic Jacobsen Group III and Group IV in reactions, solvent and indole, 1 addition of allylic groups epoxidation, reductions. (i) NaBH4, neighbouring group benzofuran, from boron compounds triacetoxyborohydride effects, benzothiophene, quinoline, S- phenanthroline 6 heteroatomic polycyclic stereoselective alkene Hydride transfer reagents from mechanisms of radical hydrocarbons, SLO- synthesis, nucleophilic Group III and Group IV in reactions, solvent and indole, Shi epoxidation 2 addition of allylic groups reductions. (i) NaBH4, neighbouring group benzofuran, from boron compounds triacetoxyborohydride effects, benzothiophene, quinoline, phenanthroline alkenes to diols (manganese, Organosilicon osmium based), aromatic compounds, general Sharpless Hydride transfer reagents from free radical SLO- stabilization, features carbon-carbon asymmetric Group IV in reductions. L- substitutions at aliphatic 1 electron bondforming reactions of dihydroxylation, selectride, Kselectride substrates delocalization organosiliconcompounds Prevost reaction and Woodward S- modification 7 alkenes to diols (manganese, Organosilicon osmium based), aromatic compounds, general Sharpless Hydride transfer reagents from free radical SLO- stabilization, features carbon-carbon asymmetric Group IV in reductions. L- substitutions at aliphatic 2 electron bondforming reactions of dihydroxylation, selectride, Kselectride substrates delocalization organosiliconcompounds Prevost reaction and Woodward modification SLO- S- 1 Tutorial Tutorial Tutorial Tutorial Tutorial 8 SLO- 2 alkenes to carbonyls with bond cleavage acylation reactions, free radical SLO- (manganese, Luche reduction, LiAlH4, DIBAL- conjugate addition substitutions at Synthesis 1 osmium, H, and Red-Al, MPV reduction) reactions. aromatic substrates ruthenium and lead based, S- ozonolysis) 9 alkenes to carbonyls with bond cleavage acylation reactions, free radical SLO- (manganese, Luche reduction, LiAlH4, DIBAL- conjugate addition substitutions at Synthesis 2 osmium, H, and Red-Al, MPV reduction) reactions. aromatic substrates ruthenium and lead based, ozonolysis) alkenes to alcohols/carbonyls cyclization of free Organotincompounds, Stereo/enantioselective reductions SLO- without bond radical intermediates, synthesis of (chiral boranes, Corey-Bakshi- Reactivity 1 cleavage additions to C=N double organostannanes, Shibata reduction) S- (hydroboration- bonds 10 oxidation, etc. alkenes to cyclization of free Organotincompounds, Stereo/enantioselective reductions SLO- alcohols/carbonyls radical intermediates, synthesis of (chiral boranes, Corey-Bakshi- Reactivity 2 without bond additions to C=N double organostannanes, Shibata reduction) cleavage bonds

27 M.Sc.Organic Chemistry (hydroboration- oxidation, etc.

fragmentation and rearrangement carbon-carbon bond ketones to Applications of SLO- Clemmenson and Wolff-Kishner reactions, forming reactions using ester/lactones these 1 reduction intramolecular tin reagents. (Baeyer-Villiger) compounds functionalization by S- radical reactions 11 fragmentation and rearrangement carbon-carbon bond ketones to Applications of SLO- Clemmenson and Wolff-Kishner reactions, forming reactions using ester/lactones these 2 reduction intramolecular tin reagents. (Baeyer-Villiger) compounds functionalization by radical reactions SLO- S- 1 Tutorial Tutorial Tutorial Tutorial Tutorial 12 SLO- 2

1. J. Clayden, N. Greeves, S. Warren and P. Wothers, Organic Chemistry, 1st Ed., Oxford University Press, 2001. 2. M.B. Smith & J. March, March’s Advanced Organic Chemistry, 6thEd., John Wiley & Sons, New York, 2007. 3. F.A. Carey and R.A. Sundberg, Advanced Organic Chemistry, Part A and Part B, 5thEd., Kluwer Academic/Plenum Publishers, Learning New York, 2004. Resources Unit-II: Chapter 9, 20, 22 (Clayden), Chapter 15,16, 18 (Smith), Chapter 7, 9 (Carey). Unit-III: Chapter 9, 20, 22 (Clayden), Chapter 19 (Smith). Unit-IV: Chapter 41 (Clayden), Chapter 19 (Smith), Chapter 5 (Carey). 4. Clar, E. (1964). Polycyclic Hydrocarbons. New York, NY: Academic Press. LCCN 63012392.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Experts from Industry Expert from Higher Technical Institutions Internal Experts 1. Prof. G. Sekar, Department of Chemistry, IIT Madras Dr. Anjan Bedi, SRMIST Dr. Ravikiran Allada, Head R&D, Analytical, Email: [email protected] Novugen Pharma, Malaysia Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Dr. Susnata Pramanik, SRMIST Bengaluru Email: [email protected]

======

28 M.Sc.Organic Chemistry

Course Course Heterocyclic Chemistry and Total synthesis Course L T P C POC21203T C Professional Core Course Code Name of Natural products Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

give the student a broad understanding of the major CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 classes of heterocyclic compounds The student will learn nomenclature, structure, properties, CLR-2 : syntheses, and reactions of non-aromatic heterocycles The student will learn nomenclature, structure, properties, CLR-3 : syntheses, and reactions of aromatic heterocycles learn various nucleophilic, substitution and electrophilic CLR-4 : reactions in heterocyclic chemistry

learn the importance of naturally occurring alkaloids,

CLR-5 :

terpenoids and antibiotics

learn the concepts of retrosynthetic approach, the art and

CLR-6 :

science of total synthesis

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life Understand the structures, syntheses, reactions, and CLO-1 : 2 75 60 H H H L H H M H H L H H H H H properties of the major classes of heterocyclic compounds Predict the nucleophilic and electrophilic reaction CLO-2 : 2 80 70 H H L H L L H L L H H L H H H mechanisms, catalyst and rearrangements reactions Able to draw mechanisms for reactions involving heterocycles as starting materials, intermediates and CLO-3 : products, and to propose syntheses of heterocycles from 2 70 65 H H H M L L H L L H H L H H H the major classes Explain the classification of alkaloids, terpenoids and their CLO-4 : 2 70 70 H L H H H L M L L H H L H H H importance and uses To evaluate and propose syntheses of complex natural CLO-5 : 2 80 70 L H L M L H H L L H H L H H H products Learn the broad class of synthetic transformations CLO-6 : including asymmetric transformation, coupling reactions, 2 75 70 H H H H H H H H H H H H H H H selective redox reactions in the total synthesis

Duration (hour) 12 12 12 12 12 Nomenclature of Tautomerism in Reactions of pyrrole, furan Total synthesis of SLO-1 heterocyles: Common aromatic heterocycles Synthesis of azirines and thiophene forskolin Name Nomenclature and factors S-1 General trends in the Reactions of pyrazole The replacement Total synthesis of SLO-2 reactivity of aromatic Synthesis of azirines nomenclature forskolin heterocycles The Hantzsch-Widman nomenclature for Strain in small ring Synthesis of pyrrole, furan Reactions of imidazole, Importance and uses SLO-1 Monocyclic heterocycles and thiophene oxazole and thiazole of reserpine S-2 heterocycles The Hantzsch-Widman Consequences of Bond Retrosynthetic Synthesis of pyrrole, furan Reactions of pyrimidine and SLO-2 nomenclature for angle strain in small synthesis of and thiophene pyrazine Fused heterocycles ring heterocycles reserpine The Hantzsch-Widman Consequences of Bond Woodward’s Reactions of benzofuran, SLO-1 nomenclature for angle strain in small Synthesis of pyrazole synthesis of indole and benzothiophene bridged heterocycles ring heterocycles reserpine Effect of heteroatoms S-3 on organic reactions in Woodward’s comparison with Conformation of six- Reactions of of pyridine, SLO-2 Synthesis of pyrazole synthesis of carbogenic membered heterocycles quinoline and isoquinoline reserpine compounds-Physical Properties S-4 SLO-1 Tutorial Tutorial Tutorial Tutorial Tutorial

29 M.Sc.Organic Chemistry Duration (hour) 12 12 12 12 12 SLO-2 Tutorial Tutorial Synthesis of imidazole Tutorial Tutorial Effect of heteroatoms Synthesis of imidazole Synthesis of six membered Importance and uses SLO-1 on organic reactions Barrier to ring inversion rings containing two of cholesterol Chemical Properties heteroatoms S-5 Synthesis of imidazole Reactions of synthesis of six Woodward’s Heterocycles in organic SLO-2 Pyramidal inversion membered rings containing synthesis of synthesis two heteroatoms cholesterol Synthesis of oxazole and Woodward’s Heterocycles in Introduction and importance SLO-1 1,3-diaxial interactions thiazole synthesis of biomolecules of natural products cholesterol S-6 Synthesis of oxazole and Corey’s synthesis of Oxidation in Factors affecting Introduction to SLO-2 thiazole prostaglandins (E2, heterocyclic chemistry anomeric effect Retrosynthetic analysis F2α), Synthesis of pyrimidine Corey’s synthesis of Reductions in Consequences of SLO-1 and pyrazine Total synthesis of Penicillin prostaglandins (E2, heterocyclic chemistry anomeric effect F2α), S-7 Double anomeric Synthesis of pyrimidine Aromatic heterocycles: effect,Rabbit-ear effect and pyrazine Importance and uses SLO-2 Total synthesis of Penicillin classification (lone pair-lone pair of taxol interactions) SLO-1 Tutorial Tutorial Tutorial Tutorial Tutorial S-8 SLO-2 Tutorial Tutorial Tutorial Tutorial Tutorial Repulsive-gauche Synthesis of benzofuran, Alkaloids: Morphine. Retrosynthetic SLO-1 Criteria of aromaticity effect (hockey-sticks indole and importance and uses approach of taxol effect) benzothiophene S-9 Hydrogen bonding and Synthesis of benzofuran, Structural Criteria: intermolecular indole and Retrosynthetic analysis of Nicolaou’s synthesis SLO-2 Bond length nucleophilic, benzothiophene morphine of taxol electrophilic interactions Electronic Criteria: Basic principles of Synthesis of pyridine, Nicolaou’s synthesis SLO-1 Total synthesis of morphine Dipole moment heterocycle synthesis quinoline and isoquinoline of taxol S-10 Synthesis of pyridine, Danishefsky’s Energetic Criteria: SLO-2 Baldwin’s Rule quinoline and isoquinoline Total synthesis of morphine synthesis of Delocalization energy indolizomycin Energetic Criteria: Danishefsky’s Terpenes: Forskolin. SLO-1 Dewar Resonance Synthesis of aziridines Reactions of azirines synthesis of Importance and uses Energy indolizomycin S-11 Magnetic Criteria: Ring Retrosynthetic analysis of current and chemical forskolin Takasago synthesis SLO-2 Reactions of aziridines Reactions of azirines shifts in 1H NMR- of menthol spectra SLO-1 Tutorial Tutorial Tutorial Tutorial Tutorial S-12 SLO-2 Tutorial Tutorial Tutorial Tutorial Tutorial

1. T. L. Gilchrist, Heterocyclic Chemistry, 3rd Ed., Prentice Hall, 1997. 2. A. R. Katritzky, and C. W. Rees, Comprehensive Heterocyclic Chemistry, Pergamon Press, 1996. Learning 3. R. R. Gupta, M. Kumar, and V. Gupta, Heterocyclic Chemistry, Vo1.1-3, Springer Verlag, 2008. Resources 4. D. T. Davies, Aromatic Heterocyclic Chemistry, Oxford Chemistry Primers, 1992. 5. K. C. Nicolaou, Classics in total synthesis, Wiley, 1996.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

30 M.Sc.Organic Chemistry

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Experts from Industry Expert from Higher Technical Institutions Internal Experts 1. Prof. G. Sekar, Department of Chemistry, IIT Dr. Ravikiran Allada, Head R&D, Analytical, Madras 1. Dr. Gopal Chandru Senadi, SRMIST Novugen Pharma, Malaysia Email: [email protected] Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru 2. Dr. P. Gopinath, SRMIST Email: [email protected]

======

31 M.Sc.Organic Chemistry

Course Course Course L T P C POC21204T Modern Methods of Organic Synthesis C Professional Core Course Code Name Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

enable them to learn the different types methods in CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Organic synthesis. Strengthen the knowledge of the students in organic CLR-2 : reactions. explore new methodology of organic transformations CLR-3 : through the knowledge of the core content. get a significant exposure in research and development CLR-4 :

for future development.

Express their capabilities as an organic chemist in

CLR-5 :

pharmaceutical industries.

CLR-6 : Strengthen the skill in the area of organic synthesis.

Attainment Attainment (%)

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life CLO-1 : Understand the basic principles of pericyclic reactions. . 2 75 60 H H H L H H M H H L H H H H H Acquaint students with the fundamental concepts of CLO-2 : 2 80 70 H H L H L L H L L H H L H H H Molecular orbital symmetry and Cyclo addition reactions. Gain knowledge about various molecular rearrangement CLO-3 : 2 70 65 H H H M L L H L L H H L H H H reactions. CLO-4 : Understand the concept of retrosynthetic analysis 2 70 70 H L H H H L M L L H H L H H H CLO-5 : Gain knowledge about the in multistep organic synthesis. 2 80 70 L H L M L H H L L H H L H H H Acquaint students with the understanding of designing CLO-6 : 2 75 70 H H H H H H H H H H H H H H H easily achievable cost effective synthetic route.

Duration (hour) 12 12 12 12 12 Molecular orbital Introduction to Wagner-Meerwein Favorskii rearrangement in Basic Concepts in SLO-1 symmetry cycloaddtions reactions Rearrangement various system organic synthesis S-1 Frontier orbitals of Linear and Nametkin Favorskii rearrangement in SLO-2 several organic Antarafacial additions convergent Rearrangement various system molecules synthesis Frontier orbitals of Pinacol Pinacolone Linear and SLO-1 several organic Suprafacial additions Rearrangement and Fries Rearrangement convergent molecules retropinacol synthesis S-2 Classification of Benzil-Benzilic acid Disconnection SLO-2 pericyclic Notation of cycloadditions McLafferty rearrangement rearrangements approach reactions Cycloadditions of (4n) Introduction to Benzil-Benzilic acid Hoffman, Curtius Disconnection SLO-1 ,(4n+2) (2+2) and (4+4) FMO approach rearrangements rearrangement approach systems. S-3 Cycloadditions of (4n) Rearrangement Functional group Introduction to Schmidt and Lossen SLO-2 ,(4n+2) (2+2) and (4+4) involving interconversions FMO approach rearrangements. systems diazomethane (FGI) SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-4 Question answer Question answer Question answer SLO-2 Question answer Session Question answer Session Session Session Session Woodward- Rearrangement Functional group Hoffman SLO-1 (2+2), additions of ketones involving Beckmann rearrangement interconversions correlation diazomethane (FGI) diagram method S-5 Introduction to Baker– Perturbation of Baeyer–Villiger Functional group SLO-2 Chelotropic reactions Venkataraman molecular (PMO) rearrangement addition (FGA) rearrangement approach Introduction to FMO approach for the Bamberger Functional group S-6 SLO-1 Dakin reaction Perturbation of explanation of rearrangement addition (FGA)

32 M.Sc.Organic Chemistry Duration (hour) 12 12 12 12 12 molecular (PMO) sigmatropic approach rearrangements Explanation of PMO approach for the pericyclic Benzidine, Semidine Functional group SLO-2 explanation of sigmatropic Dakin reaction Reactions under Rearrangement, removal (FGR) rearrangements thermal condition Explanation of pericyclic Suprafacial and Carroll Dienone-phenol Functional group SLO-1 Reactions under antarafacial shifts of rearrangement, rearrangement removal (FGR) Photochemical hydrogen S-7 condition Introduction to Importance of sigmatropic shift involving Chapman Hofmann-Martius SLO-2 Electrocyclic order of events in carbon moieties Rearrangement Rearrangement reactions organic synthesis SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-8 Question answer Question answer Question answer SLO-2 Question answer Session Question answer Session Session Session Session One and two group Condolatory and (3,3) sigmatropic Overman Fischer-Hepp SLO-1 C-X motions rearrangements, Rearrangement, Rearrangement disconnections S-9 Chemoselectivity, Disrotatory (5,5) sigmatropic Gabriel–Colman Fritsch–Buttenberg–Wiechell regioselectivity, SLO-2 motions rearrangements, rearrangement rearrangement stereoselectivity, enantioselectivity Electrocyclic Stevens Fritsch–Buttenberg–Wiechell Concept of SLO-1 reaction for 4n Claisen rearrangements rearrangement rearrangement umpolung system S-10 Generation of acyl Electrocyclic Sommelet anion equivalent SLO-2 reaction for (4n+2) Cope rearrangements Neber rearrangement rearrangement using 1, 3- system dithianes,. Generation of acyl Electrocyclic anion equivalent reaction of allyl Wittig using methyl SLO-1 Fluxional tautomerism, Koch-half carbonylation systems and rearrangements. thiomethyl secondary effects sulfoxides, cyanide ions, S-11 Generation of acyl Electrocyclic anion equivalent reaction of allyl Wittig using cyanohydrin SLO-2 Aza-Cope rearrangements Stevens Rearrangement systems and rearrangements. ethers, nitro secondary effects compounds and vinylated ethers SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-12 Question answer Question answer Question answer SLO-2 Question answer Session Question answer Session Session Session Session

1. J. Clayden, N. Greeves, S. Warren and P. Wothers, Organic Chemistry, 1st Ed., Oxford University Press, 2001. 2. M.B. Smith & J. March, March’s Advanced Organic Chemistry, 5th Ed., John Wiley & Sons, New York, 2001. 3. F.A. Carey and R.A. Sundberg, Advanced Organic Chemistry, Part A and Part B, 5th Ed., Kluwer Academic/Plenum Learning Publishers, New York, 2004 Resources 4. P. G. M. Wuts, Greene's Protective Groups in Organic Synthesis, 5th Ed., Wiley, 2014. 5. Peter Sykes, A Guide book to Mechanism in Organic Chemistry, 6th Ed., Orient ongman Ltd., New Delhi, 1997. 6. S. M. Mukherjee and S.P. Singh, Reaction Mechanism in Organic Chemistry, 1st Ed., Macmillan India Ltd., New Delhi, 1990. 7. 7. T.H. Lowry and K.S. Richardson, Mechanism and Theory in Organic Chemistry, 3rd Ed., Addison–Wesley.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

33 M.Sc.Organic Chemistry

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru Centre

for Advanced Scientific Research (JNCASR), 2. Dr. Gopal Chandru Senadi, SRMIST Bengaluru Email: [email protected]

======

34 M.Sc.Organic Chemistry

Course Course Course L T P C PCY21D04T Nanomaterials and Nanochemistry D Discipline Elective Course Code Name Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

CLR-1 : Acquire sound knowledge about nanochemistry 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 CLR-2 : Understand the fundamentals of nanochemistry Learn the synthesis of nanomaterials CLR-3 :

Gain deep knowledge about the analytical techniques to

CLR-4 :

characterize the nanomaterials

CLR-5 : Learn carbon nanostructures and their synthesis

CLR-6 : Learn the application of nanomaterials in catalysis

Reasoning

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life Understand the phenomenon underlying the nanomaterials CLO-1 : 2 75 60 H H H L H H M H H L H H H H H based products in use Identify the suitable methods for the synthesis of any CLO-2 : 2 80 70 H H L H L L H L L H H L H H H specific nanomaterial Guide for the suitable technique to characterize CLO-3 : 2 70 65 H H H M L L H L L H H L H H H nanomaterial and understand the obtained results Synthesize and carbon nanomaterials and modify them CLO-4 : 2 70 70 H L H H H L M L L H H L H H H and design based on the requirement Understand the parameters responsible for the catalytic CLO-5 : efficiency of nanomaterials and tune them for better 2 80 70 L H L M L H H L L H H L H H H performance Design a specific nanomaterial, synthesize them, CLO-6 : 2 75 70 H H H H H H H H H H H H H H H characterize and modify based on the application focused

Duration (hour) 12 12 12 12 12 Discussion on various techniques Introduction to available for nanoscience Basics of nanofabrication Bonding in carbon, new Nanocatalysis: SLO-1 characterizing the and methods carbon structures fundamentals nanomaterials for nanotechnology S-1 their size, shape, morphology Introduction to Scanning electron homogeneous vs nanoscience top-down, bottom-up Bonding in carbon, new SLO-2 microscope (SEM) heterogeneous and approaches carbon structures and examples catalysis nanotechnology Discussion on various techniques discussion on effect of surface available for various gas phase, liquid phase, area, SLO-1 characterizing the carbon clusters phenomenon at solid phase synthesis effect of particle nanomaterials for nanoscale size their size, S-2 shape, morphology Transmission electron discussion on self-assembly, templated microscope(TEM), shape and SLO-2 discovery of C60 nano size synthesis examples and a morphology comparison with SEM Discussion on various techniques alkali doped discussion on available for effect of S-3 SLO-1 Sol-gel synthesis C60,superconductivity in nano shape characterizing the composition C60 nanomaterials for crystalline phase

35 M.Sc.Organic Chemistry Duration (hour) 12 12 12 12 12 discussion on Synthesis through X-ray powder bimetallic system SLO-2 larger and smaller fullerenes nano surface electrodeposition diffraction (XRD) etc SLO-1 Tutorial Tutorial Tutorial Tutorial Tutorial S-4 SLO-2 Tutorial Tutorial Tutorial Tutorial Tutorial Discussion on various techniques nanomaterials for Discussion on fundamentals of available for photo-catalysis: SLO-1 carbon nanotubes: synthesis surface energy nanoparticle formation characterizing the Introduction and S-5 nanomaterials for overview oxidation states Discussion on Thermodynamic X-ray photoelectron single SLO-2 surface approach, dye degradation spectroscope (XPS) walled carbon nanotubes stabilization supersaturation textural properties structure and characteristic Nucleation and organic SLO-1 (surface area, pore characterization of carbon length growth of nanoparticles transformations volume, pore size) nanotubes S-6 N2 sorption structure and techniques for plasmon assisted SLO-2 self-assembly homo vs hetero nucleation characterization of carbon textural properties of photo-catalysis nanotubes the materials Synthesis of band gap tuning in SLO-1 defects nanoparticles, Metallic, Thermal analysis mechanism of formation nanomaterials semiconducting S-7 Synthesis of band gap tuning chemically SLO-2 size quantization nanoparticles, Metallic, TGA and photocatalytic modified carbon nanotubes semiconducting performance SLO-1 Tutorial Tutorial Tutorial Tutorial Tutorial S-8 SLO-2 Tutorial Tutorial Tutorial Tutorial Tutorial Solid state NMR for Synthesis of characterizing Doping, functionalizing Nanomaterials for SLO-1 surface plasmon nanoparticles: quantum functionalized nanotubes water splitting dots, oxides, hybrids materials. S-9 Peculiar Examples of Synthesis of materials application of carbon Nanomaterials for SLO-2 conductivity nanoparticles: quantum characterized using nanotubes water splitting dots, oxides, hybrids NMR micelles and Scanning tunnelling Carbon nanomaterials for SLO-1 tunneling, microemulsion as microscope nanowires CO2 capture templates for synthesis (STM) S-10 Examples of synthetic strategies: gas 0D, 1D and 2D materials nanomaterials for SLO-2 magnetism phase and solution phase nanoparticles, characterized using CO2 capture growth STM Atomic force nanomaterials for SLO-1 defects core-shell nanoparticles growth control microscope (AFM) CO2 conversion S-11 special nanoparticles, Atomic force Properties of carbon nanomaterials for SLO-2 defects shaped nanoparticles microscope (AFM) nanowires CO2 conversion SLO-1 Tutorial Tutorial Tutorial Tutorial Tutorial S-12 SLO-2 Tutorial Tutorial Tutorial Tutorial Tutorial

1. C. N. R.Rao, A. Muller and A. K. Cheetam, (Eds) (2004): The Chemistry of Nanomaterials, 2. C. P. Poole, and Jr. F. J. Owens,Introduction to Nanotechnology, Wiley Interscience, New Jersey. 2003. Learning 3. K. J. Klabunde, Nanoscale materials in Chemistry, Wiley- Interscience, New York, 2001 Resources 4. T. Pradeep, Nano: The Essentials in Understanding Nanoscience and Nanotechnology, Tata McGraw Hill, New Delhi, 2007. 5. T. Tang and P. Sheng, Nano Science and Technology – Novel Structures and Phenomena, Taylor & Francis, New York, 2004 6. U. Heiz, and U. Landman,Nanocatalysis, Springer, New York, 2006

36 M.Sc.Organic Chemistry

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Experts from Industry Expert from Higher Technical Institutions Internal Experts 1. Prof. G. Sekar, IIT Madras, [email protected] Dr. Srinivasarao Dr. Ravikiran Allada, Head R&D, Analytical, Novugen Kancharla, SRMIST Pharma, Malaysia 2. Prof. Vivek Polshettiwar, TIFR Mumbai, Email: [email protected] Dr. M. Arthanareeswari, [email protected] SRMIST

======

37 M.Sc.Organic Chemistry

Course Course Course L T P C POC21D01T Advanced Green Chemistry D Discipline Elective Course Code Name Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

give a better understanding of the chemical synthesis CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 with environmental concerns Gains extensive conceptual knowledge on green and CLR-2 : sustainable process with energy efficiency Gains extensive conceptual knowledge on less CLR-3 : hazardous chemical synthesis Develop strategies to design and produce cost- CLR-4 :

competitive chemical products and processes

Minimize the environmental impact with atom economical

CLR-5 :

approach

Design chemicals that degrade and can be discarded CLR-6 :

easily.

Course

Modeling

Learning

1 2

- -

At the end of this course, learners will be able to: -

Outcomes

Application of Concepts of Application Related Disciplines with Link Knowledge Procedural Specialization in Skills Knowledge Utilize to Ability in Skills Data Interpret Analyze, Skills Investigative Skills Solving Problem Skills Communication Skills Analytical PSO PSO PSO

(CLO): Knowledge Fundamental

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected CLO-1 : At the end of this course, learners will be able to: 2 75 60 H H H L H H M H H L H H H H H CLO-2 : Understand the basic principles of green chemistry. 2 80 70 H H L H L L H L L H H L H H H gain ability for applying green synthetic methodology to CLO-3 : 2 70 65 H H H M L L H L L H H L H H H conventional reactions for energy efficiency Understand the sustainable process for essential CLO-4 : 2 70 70 H L H H H L M L L H H L H H H chemicals with atom economical route Acquaint the student with the fundamental concepts of CLO-5 : 2 80 70 L H L M L H H L L H H L H H H sustainable chemical synthesis with environmental factor Gain knowledge about the development of sustainable CLO-6 : 2 75 70 H H H H H H H H H H H H H H H route of synthesis with greener approach

Duration (hour) 12 12 12 12 12 Green synthesis in Various green Green synthesis - Aqueous phase reactions – industrial SLO-1 Green reagents-introduction synthetic methods- introduction Introduction applications - Introduction S-1 Introduction Prevention of Microwave mediated Adipic Acid - SLO-2 waste by Use of dimethylcarbonate Synthesis – Oxidation reactions synthesis products Introduction Maximum incorporation of Use of polymer supported Microwave assisted SLO-1 Reduction reactions Catechol synthesis the reactants into reagents-peracids reactions in Water the final product S-2 Prevention or MW-assisted Methyl minimization of Chemicals from renewable SLO-2 Use of NBS Synthesis of methacrylate - hazardous raw materials - introduction heterocycles synthesis products MW-assisted Designing safer Carbohydrates as renewable Aromatic amines - SLO-1 Use of chromic acid Synthesis of Ionic chemicals raw materials synthesis S-3 Liquids (ILs) Production of ethanol and SLO-2 Examples Thioanisole resin Examples Examples furfural SLO-1 Tutorial Tutorial Tutorial Tutorial Tutorial S-4 SLO-2 Tutorial Tutorial Tutorial Tutorial Tutorial Energy Polystyrene carbodiimide, Environmentally benign Microwave assisted Acetaldehyde - SLO-1 requirements for Polystyrene Anhydride, synthesis via Solid State Reactions synthesis synthesis Sulfonazide Polymer, mechanochemical mixing S-5 MW-assisted Suzuki E factors and Polystyrene Wittig and Heck Mechanically induced organic SLO-2 Furfural synthesis atom efficiency reagent reactions using transformations in a ball-mill supported Pd-catalyst

38 M.Sc.Organic Chemistry Duration (hour) 12 12 12 12 12 Selection of Ultrasound assisted Green catalysts - (S)-metolachlor SLO-1 appropriate synthesis- Synthesis of Heterocycles introduction synthesis S-6 solvent Introduction Acid Catalysts, Oxidation Applications of Ibuprofen SLO-2 Examples Synthesis of Heterocycles catalysts ultrasound synthesis Selection of Biocatalyst in organic Paracetamol SLO-1 Basic catalysts Polymerization reactions starting materials synthesis synthesis S-7 Green aspects of Use of protecting Polymer supported Microbial production SLO-2 Photochemical reactions scale-up synthesis groups catalysts of ethanol of some APIs SLO-1 Tutorial Tutorial Tutorial Tutorial Tutorial S-8 SLO-2 Tutorial Tutorial Tutorial Tutorial Tutorial Drug candidates Catalysts in continuous- Photochemical under development SLO-1 Use of catalyst Photochemical reactions flow reactors reactions or their critical S-9 intermediates, Design of Formation of a Examples of green SLO-2 biodegradable Examples Tofacitinib Citrate carbon–carbon bond photochemical reactions products Formation of C–C Polymer supported Photoinduced alkylation of Trelagliptin SLO-1 Examples bonds via coupling photosensitizers alkenes succinate reactions S-10 Designing of Phase transfer catalysis – Alkynes by alkanes, alcohols Cetirizine SLO-2 manufacturing Examples Introduction and alkyl halides dihydrochloride plants Strengthening of Synthesis of phase Electrochemical SLO-1 analytical Electrochemical synthesis, 3-phenyl catechol transfer catalysts synthesis S-11 techniques Applications of PTC in solvent free solid phase SLO-2 Examples Examples Nicotinic acid organic synthesis organic synthesis SLO-1 Tutorial Tutorial Tutorial Tutorial Tutorial S-12 SLO-2 Tutorial Tutorial Tutorial Tutorial Tutorial

1. Text Books and References 2. 1. Green Chemistry, theory and practice, Paul T. Anastas and John C. Warner. 3. 2 New Trends in Green chemistry, V. K. Ahluwalia and M. Kidwai. Learning 4. 3. Organic Synthesis: Special techniques, V. K. Ahluwalia and Renu Aggarwal Resources 5. 4. Introduction to Green Chemistry by V.Kumar. 6. 5. Bioorganic Chemistry: A Chemical Approach to Enzyme Action, Hermann Dugas and C. Penny, Springer Verlag. 7. 6. Biotransformation in organic chemistry, Kurt Faber, Springer.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

39 M.Sc.Organic Chemistry # CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru Centre

for Advanced Scientific Research (JNCASR), 2. Dr. P. Gopinath, SRMIST Bengaluru Email: [email protected]

40 M.Sc.Organic Chemistry

Course Course Course L T P C POC21D02T Asymmetric and Enzymatic Synthesis D Discipline Elective Course Code Name Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

introduce the students with the most updated developing CLR-1 : area in Organic Synthesis 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 . CLR-2 : enable them to learn idea of asymmetric synthesis enable them to think of multistep synthesis of important CLR-3 : organic molecules help the understand the role of organocatalysts in organic CLR-4 :

synthesis

CLR-5 : explore them to the enzyme structure and reactivity

learn about the applications of enzymes in organic

CLR-6 : (Bloom)

synthesis.

Competence

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Multicultural ICTSkills Learning Long Life Understand the methods and fundamentals of asymmetric CLO-1 : 2 75 60 H H H L H H M H H L H H H H H synthesis Understand the use of organocatalysts in organic CLO-2 : 2 80 70 H H L H L L H L L H H L H H H synthesis CLO-3 : Understand the preparation and use of NHC 2 70 65 H H H M L L H L L H H L H H H Comprehend biocatalysis and their role in organic CLO-4 : 2 70 70 H L H H H L M L L H H L H H H synthesis CLO-5 : Gain knowledge about the different organocataly 2 80 70 L H L M L H H L L H H L H H H Plan the multistep organic synthesis of important optically CLO-6 : 2 75 70 H H H H H H H H H H H H H H H active molecules

Duration 12 12 12 12 12 (hour) Asymmetric Biocatalytic Introduction to biocatalysts, synthesis: chiral oxidation Introduction to Carbenes as advantages and SLO-1 auxiliaries, methods reactions of organocatalysis organocatalysts disadvantages of of asymmetric alcohols and biocatalysts induction aldehydes S-1 Asymmetric Biocatalytic Introduction to biocatalysts, synthesis: chiral oxidation Introduction to Carbenes as advantages and SLO-2 auxiliaries, methods reactions of organocatalysis organocatalysts disadvantages of of asymmetric alcohols and biocatalysts induction aldehydes biocatalytic carbon-carbon substrate, reagent types of different isolated enzymes vs. whole bond formations, SLO-1 and catalyst Lewis acid catalysis NHCs and their cell systems, brief overview aldol reaction, controlled reactions synthesis of structure of enzymes Michael-type additions, S-2 biocatalytic carbon-carbon substrate, reagent types of different isolated enzymes vs. whole bond formations, SLO-2 and catalyst Lewis acid catalysis NHCs and their cell systems, brief overview aldol reaction, controlled reactions synthesis of structure of enzymes Michael-type additions, determination of thiamine- enantiomeric and NHC catalyzed mechanistic aspects of dependant SLO-1 diastereomeric Lewis base catalysis umpolung enzyme catalysis benzoin excess, condensation S-3 enantiodiscrimination, thiamine- determination of NHC catalyzed mechanistic aspects of dependant SLO-2 enantiomeric and Lewis base catalysis transesterification enzyme catalysis benzoin diastereomeric reactions condensation

41 M.Sc.Organic Chemistry Duration 12 12 12 12 12 (hour) excess, enantiodiscrimination, SLO-1 S-4 Tutorial Tutorial Tutorial Tutorial Tutorial SLO-2 cyanohydrin resolution – optical oxidative NHC classification and SLO-1 iminium catalysis formation, amino and kinetic catalysis nomenclature transfer reaction S-5 cyanohydrin resolution – optical oxidative NHC classification and SLO-2 iminium catalysis formation, amino and kinetic catalysis nomenclature transfer reaction asymmetric oxidation cooperative halogenations [epoxidation: coenzymes, enzyme SLO-1 enamine catalysis catalysis with metal and Sharpless, Jacobsen, sources catalysts dehalogenations Shi) S-6 asymmetric oxidation cooperative halogenations [epoxidation: coenzymes, enzyme SLO-2 enamine catalysis catalysis with metal and Sharpless, Jacobsen, sources catalysts dehalogenations Shi) enzymes in cooperative biocatalysed hydrolytic dihydroxylation organic solvents, SLO-1 Bronsted acid catalysis catalysis with other reactions, hydrolysis of (Sharpless)] ester synthesis, organocatalysts amides, esters lactone synthesis S-7 enzymes in cooperative biocatalysed hydrolytic dihydroxylation organic solvents, SLO-2 Bronsted acid catalysis catalysis with other reactions, hydrolysis of (Sharpless)] ester synthesis, organocatalysts amides, esters lactone synthesis SLO-1 S-8 Tutorial Tutorial Tutorial Tutorial Tutorial SLO-2 asymmetric reduction homo and cross Biocatalytic hydrolysis of amide synthesis, SLO-1 (Noyori, Corey, Bronsted base catalysis benzoin type epoxides and nitriles peptide synthesis Pfaltz) reactions S-9 asymmetric reduction homo and cross Biocatalytic hydrolysis of amide synthesis, SLO-2 (Noyori, Corey, Bronsted base catalysis benzoin type epoxides and nitriles peptide synthesis Pfaltz) reactions stereoselective aldol Stetter reaction, quaternary ammonium biocatalytic reduction reactions (Cram’s enolate chemistry, artificial enzyme SLO-1 salts as catalyst and reactions, recycling of rule and Felkin Anh homoenolate mimics, phase transfer catalyst cofactors models) derived reactions S-10 stereoselective aldol Stetter reaction, quaternary ammonium biocatalytic reduction reactions (Cram’s enolate chemistry, artificial enzyme SLO-2 salts as catalyst and reactions, recycling of rule and Felkin Anh homoenolate mimics, phase transfer catalyst cofactors models) derived reactions auxillary controlled Physical influence in addition to ketenes reduction of aldehydes, catalytic SLO-1 stereoselection, asymmetric synthesis and analogs ketones and C=C bonds antibodies Evans oxazolidones. S-11 auxillary controlled Physical influence in addition to ketenes reduction of aldehydes, catalytic SLO-2 stereoselection, asymmetric synthesis and analogs ketones and C=C bonds antibodies Evans oxazolidones. SLO-1 S-12 Tutorial Tutorial Tutorial Tutorial Tutorial SLO-2

1. R. Gawley and J. Aube, Principles of Asymmetric Synthesis, 2nd Ed., Elsevier, 2012. 2. K. Faber, Biotransformations in Organic Chemistry, 6th Ed., Springer, 2011. Learning 3. Seayad, Jayasree, and Benjamin List. "Asymmetric organocatalysis." Organic & biomolecular chemistry 3.5 (2005): 719-724. Resources 4. Hopkinson, Matthew N., et al. "An overview of N-heterocyclic carbenes." Nature 510.7506 (2014): 485-496. 5. Flanigan, Darrin M., et al. "Organocatalytic reactions enabled by N-heterocyclic carbenes." Chem. Rev 115.17 (2015): 9307-9387.

42 M.Sc.Organic Chemistry Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Expert from Higher Technical Experts from Industry Internal Experts Institutions 1. Prof. G. Sekar, Department of Chemistry, IIT Madras Dr. Ravikiran Allada, Head R&D, Analytical, Dr. Anjan Bedi SRMIST Email: [email protected] Novugen Pharma, Malaysia

Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal

Nehru Centre for Advanced Scientific Dr. Gopal Chandru Senadi, SRMIST Research (JNCASR), Bengaluru Email: [email protected]

======

43 M.Sc.Organic Chemistry

Course Course Organic Chemistry Practical: Functional Course L T P C POC21S01L S Skill Enhancement Course Code Name groupm analysis and synthesis Category 0 0 6 3

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

gain exposure to the practical knowledge of organic CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 reactions gain insight about the setting up a basic reaction for CLR-2 : synthesis of simple compounds learn about the analysis of different organic functional CLR-3 : groups gain knowledge about the structural elucidation of CLR-4 :

synthesized compounds using different techniques

know how to maintain the record of experiments

CLR-5 :

conducted

CLR-6 : learn strategies for the synthesis of drug molecules

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life understand different purification techniques in organic CLO-1 : chemistry like recrystallization, distillation, steam 2 75 60 H H H L H H M H H L H H H H H distillation and extraction. get awareness of safety techniques and handling of CLO-2 : 2 80 70 H H L H L L H L L H H L H H H chemicals. understand how to carry out different types of reactions CLO-3 : 2 70 65 H H H M L L H L L H H L H H H and their workup methods. understand the Principles of mass spectroscopy, gas CLO-4 : 2 70 70 H L H H H L M L L H H L H H H chromatography and HPLC apply the techniques for structure determination of organic CLO-5 : 2 80 70 L H L M L H H L L H H L H H H molecules. CLO-6 : Acquire insight about the setting up a reaction 2 75 70 H H H H H H H H H H H H H H H

Duration (hour) 18 18 18 18 18 SLO-1 Introduction Spectroscopic Techniques: 6. Cyclohexanone → Compounds to be synthesized by 3. 4-Nitrobenzoic acid to S-1 to Phenyl hydrazone → one step reaction have to be 4-nitrobenzanilide 3. Mixture 3 6. Mixture 6 6 1,2,3,4- SLO-2 characterized by modern (Substitution) Tetrahydrocarbazole spectroscopic techniques (UV-Vis, FT-IR, NMR). Analysis of an organic 4. o-Chlorobenzoic acid S-7 to SLO-1 1. 2,4,6-trinitrophenol(picric mixture containing two from anthranillic acid 4. Mixture 4 Repeat Class -1 12 acid)from phenol (nitration) components: (Sandmeyer reaction) SLO-2 1. Mixture 1 2. Benzophenoneoxime from 5. 4-Nitro toluene → 4- S-13 to SLO-1 benzophenone (addition Nitro benzoic acid → 4- 2. Mixture 2 5. Mixture 5 Repeat Class -2 18 SLO-2 reaction) Amino benzoic acid

References 1. Vogel, A Textbook of Practical Organic Chemistry, 5th Ed., Prentice Hall, 1996. Learning 2. Fieser and Fieser, Reagents in Organic Synthesis, Wiley, 2006. Resources 3. Mann &Saunders, Practical Organic Chemistry, 4thEd., Longmans, 1960. 4. H. T. Clarke., A Handbook of Quantitative & Qualitative Analysis, Arnold Heinemann, 1975.

44 M.Sc.Organic Chemistry Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 - 30% - 30% - 30% - 30% - 30% Understand Apply Level 2 - 40% - 50% - 50% - 50% - 50% Analyze Evaluate Level 3 - 30% - 20% - 20% - 20% - 20% Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Expert from Higher Technical Experts from Industry Internal Experts Institutions 1. Prof. G. Sekar, Department of Chemistry, IIT Madras Dr. Baskar Baburaj, SRMIST Dr. Ravikiran Allada, Head R&D, Email: [email protected] Analytical, Novugen Pharma, Malaysia Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru Centre for Advanced Scientific Dr. Susnata Pramanik, SRMIST Research (JNCASR), Bengaluru Email: [email protected]

======

45 M.Sc.Organic Chemistry

Course Course General Aptitude for Competitive Course L T P C PCD21AE2T A Ability Enhancement Course Code Name Examinations Category 1 0 0 1

Pre-requisite Co-requisite Progressive Nil Nil Nil Courses Courses Courses Course Offering Career Development Centre Data Book / Codes/Standards Nil Department

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR): CLR-1: recapitulate fundamental mathematical concepts and skills 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 CLR-2: provide context - based vocabulary enhancement

CLR-3: sharpen logical reasoning through skilful conceptualization

CLR-4: familiarize with basic grammatical and syntactical rules

CLR-5: enable to solve problems and to crack competitive exams

CLR-6: develop new strategies to enhance reading comprehension

Course

2 3

Learning 1

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

(CLO):

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life PSO PSO PSO build a strong base in the fundamental mathematical CLO-1: 2 80 75 H H H H H H H H H H M H H H H concepts CLO-2: acquire strategies to build vocabulary 2 80 70 H H H H H H H H H H M H H H H apply the learn conditions towards solving problems CLO-3: 2 75 70 H H H H H H H H M H M H H H H analytically CLO-4: learn grammatical and syntactical rules 2 80 75 H H H H H H H H H H M H H H H grasp the approaches and strategies to solve problems CLO-5: 2 80 70 H H H H H H H H H H M H H H H with speed and accuracy CLO-6: improve reading comprehension strategies 2 80 75 H H H H H H H H H H M H H H H

Duration 3 3 3 3 3 (hour) Vocabulary from inference SLO-1 Logical Reasoning I Numbers - I Error Identification - I Data Sufficiency to meaning S-1 Vocabulary from inference SLO-2 Solving Problems Numbers - I Error Identification - I Data sufficiency to meaning

SLO-1 Logical Reasoning - I Cloze passage Numbers - II Error Identification - II Data Interpretation S-2 SLO-2 Solving Problems Cloze passage Numbers - II Error Identification - II Data Interpretation

SLO-1 Logical Reasoning - I Sentence Completion Numbers - III Sentence Correction - I Sentence Correction - II S-3 SLO-2 Solving problems Numbers - III Sentence Correction - I Sentence Correction - II Sentence Completion

1. Quantitative aptitude – r s agarwal Learning 4. GRE Contextual.Vocabulary–Ken Springer 2. Quantitative aptitude – ARUN SARMA Resources 3. ManhattanPrepGMAT Sentence Correction Guide–Avi Gutman

Learning Assessment Bloom’s Continuous Learning Assessment (50% weightage) Final Examination (50% weightage) Level of CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Level Remember - - - - 30 % - 30 % 30 % 30 % 30 % 1 Understand Level Apply - - - - - 40 % 40 % 40 % 40 % 40 % 2 Analyze Level Evaluate - - - - - 30 % 30 % 30 % 30 % 30 % 3 Create Total 100 % 100 % 100 % 100 % 100 % # CLA – 4 can be from any combination of these: Assignments, Seminars, Scientific Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications etc.,

46 M.Sc.Organic Chemistry

Course Designers Experts from Industry Internal Experts 1. Mr Nishith Sinha, dueNorth India Academics LLP, 1. Dr.P.Madhusoodhanan SRMIST 3. Dr. A Clement, SRMIST Dehradun,[email protected] 2.Mr Ajay Zenner, Career Launcher, [email protected] 2. Dr.M.Snehalatha SRMIST 4. Dr. J Jayapragash, SRMIST

======

47 M.Sc.Organic Chemistry Semester-III

Course Course Modern Synthetic Reagents and Course L T P C POC21301T C Professional Core Course Code Name Photochemistry Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

enable them to learn about different types of Organic CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 reagents and methods used in modern organic synthesis. Develop the skills in designing synthetic strategies for CLR-2 : various targets. explore the use of several important reagents and their CLR-3 : implication in the modern organic transformations. get a significant exposure in research and development CLR-4 :

for future development.

Develop capabilities as an organic chemist in

CLR-5 :

pharmaceutical industries.

CLR-6 : Strengthen knowledge in the area of organic synthesis.

Course

Learning Work

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research Team Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life CLO-1 : Understand the basic principles of photochemistry. 2 75 60 H H H L H H M H H L H H H H H Acquaint students with the use of protecting groups in CLO-2 : 2 80 70 H H L H L L H L L H H L H H H organic synthesis. Gain knowledge about various important reagents and CLO-3 : 2 70 65 H H H M L L H L L H H L H H H methods in organic Synthesis. CLO-4 : Understand the principles of asymmetric synthesis. 2 70 70 H L H H H L M L L H H L H H H CLO-5 : Gain knowledge about the in multistep organic synthesis. 2 80 70 L H L M L H H L L H H L H H H Acquaint students with the understanding of designing CLO-6 : 2 75 70 H H H H H H H H H H H H H H H easily achievable cost effective synthetic route.

Duration (hour) 12 12 12 12 12 Functional group transformations Introduction to Absorption of light by Principles of using various Role of Palladium catalyst SLO-1 Protecting group in organic molecules, Jablonski asymmetric oxidizing in organic reactions organic synthesis diagram synthesis reagents (PCC, S-1 PDC, PFC) Functional group transformations Qualities of a Good Properties of excited states, Introduction, the Role of Nickel catalyst in SLO-2 using oxidizing Protecting Group in mechanism of excited state chiral pool in organic reactions reagents (CTAP, Organic Synthesis processes Nature RuO4, KBrO3) Functional group transformations Qualities of a Good Methods of using Reducing Methods of preparative SLO-1 Heck, Negishi reaction Protecting Group in asymmetric reagents photochemistry Organic Synthesis induction (NaCNBH3, S-2 Bu3SnH) Functional group transformations Photochemistry of alkenes Substrate Protecting groups for SLO-2 using Reducing Suzuki- Miyaura, Kumada, and related compounds: controlled N. reagents (Et3SiH isomerization reactions and Hydrazine) Functional group transformations Di-π-methane Reagent and Sonogashira, Stille and SLO-1 using the Protecting groups for O rearrangement and catalyst controlled Hiyama coupling reagents SOCl2, cycloadditions reactions S-3 PBr3, PPh3-CCl4 Functional group Photochemistry of aromatic Synthesis of L- Buchwald-Hartwig Protecting groups for SLO-2 transformations compounds: ring DOPA [Knowles’s coupling for the carbon- Sulphur like alcohol using the isomerization Mosanto process]

48 M.Sc.Organic Chemistry Duration (hour) 12 12 12 12 12 reagents LiBr, heteroatom bond NaI, NBS, PPh3- formation reaction. X2 SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-4 Question Question answer Question answer SLO-2 Question answer Session Question answer Session answer Session Session Session Asymmetric Lawesson’s Organocatlysis: Lewis base Photochemistry of aromatic reactions with reagent, SLO-1 catalysis, iminium catalysis, Use of TMSI, TBAF compounds: cyclization mechanism: Aldol Mitsunobu enamine catalysis, reactions and related reagent S-5 reactions Lewis acid catalysis, Norrish type-I cleavage of Use of CH2N2, Brønsted acid and base acyclic, cyclic, and SLO-2 Use of TBDMS, BnBr Cram’s rule TMSCHN2, catalysis. Carbenes as unsaturated carbonyl organocatalysts, compounds Norrish type-I cleavage of Barbier-Weiland Different NHCs and their acyclic, cyclic, and SLO-1 Use of DHP, CbzCl Felkin-Anh model degradation synthesis, unsaturated carbonyl compounds S-6 Conversion of Use of Boc. Sharpless aldehyde to anhydride, Fmoc-Cl, SLO-2 NHC catalyzed umpolung, Norrish type-II cleavage enantioselective ketone and vice acetals as protecting epoxidation versa groups for diols. Protection of Hydrogen abstraction: Conversion of NHC catalyzed Sharpless carbonyl groups in intramolecular and SLO-1 aldehyde to transesterification enantioselective aldehydes and intermolecular hydrogen cyanide reactions hydroxylation ketones abstraction S-7 Protection of Homo and cross benzoin Conversion of carbonyl groups in Amino- SLO-2 type reactions, Stetter Photoenolization cyanide to ester aldehydes and hydroxylation reaction ketones SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-8 Question Question answer Question answer SLO-2 Question answer Session Question answer Session answer Session Session Session Conversion of Photocyclo-addition of Enolate chemistry, homo Protection of the Diels-Alder SLO-1 ketone/aldehyde ketones with unsaturated enolate derived reactions carboxyl group reaction to phenol compounds S-9 Reduction of Conversion of Addition to ketenes and Protection of double Paterno-Buchi reaction, prochiral carbonyl SLO-2 ketone to enone analogues, and triple bonds. Barton reaction compounds and olefins Synthetic utility Use of chiral of Samarium Protection of double Photodimerisation of α, β auxiliaries in SLO-1 Oxidative NHC catalysis, iodide in organic and triple bonds. unsaturated ketones diastereoselective synthesis reductions Synthetic utility S-10 Applications of the of Samarium protection and Ruthenium in Cooperative catalysis Rearrangement of enones Asymmetric, SLO-2 deprotection of the organic with metal catalysts and dienones amplification hydroxyl group in synthesis (Ring organic synthesis. closure reaction) Applications of the protection and Use of chiral Continued Cooperative catalysis deprotection of the Rearrangement of enones BINOLs, BINAPs SLO-1 (Metathesis- with metal catalysts carbonyl functional and dienones and chiral RCM) group in organic oxazolines synthesis. S-11 Synthetic utility of Applications of the Samarium Cobalt protection and in organic Cooperative catalysis with deprotection of the Asymmetric SLO-2 synthesis Photo-Fries rearrangement other organo catalysts amino and carboxyl transformations (Pauson-Khand functional groups in reaction and organic synthesis. Nicholas reaction). SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-12 Question Question answer Question answer SLO-2 Question answer Session Question answer Session answer Session Session Session

49 M.Sc.Organic Chemistry 1. J. Clayden, N.Greeves, S. Warren and P. Wothers, Organic Chemistry, 1st Ed., Oxford University Press, 2001. 2. M.B. Smith & J.March, March’s Advanced Organic Chemistry, 5th Ed., John Wiley & Sons, New York, 2001. 3. F.A. Carey and R.A. Sundberg, Advanced Organic Chemistry, Part A and Part B, 5th Ed., Kluwer Academic/Plenum Publishers, Learning New York, 2004 Resources 4. P. G. M. Wuts, Greene's Protective Groups in Organic Synthesis, 5th Ed., Wiley, 2014. 5. 5. Peter Sykes, A Guide book to Mechanism in Organic Chemistry, 6th Ed., Orient Longman Ltd., New Delhi, 1997. 6. T.H. Lowry and K.S. Richardson, Mechanism and Theory in Organic Chemistry, 3rdEd., Addison–Wesley. 7. Modern Methods of Organic Synthesis, Fourth edition by William Carruthers and Iain Coldham.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru

Centre for Advanced Scientific Research 2. Dr. Gopal Chandru Senadi, SRMIST (JNCASR), Bengaluru Email: [email protected]

======

50 M.Sc.Organic Chemistry

Course Course Course L T P C POC21302T Bioorganic Chemistry C Professional Core Course Code Name Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

develop a sound knowledge of the fundamental concepts CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 in bio-organic chemistry gain knowledge about enzymes, enzymatic reactions and CLR-2 :

inhibition

learn about amino acids and proteins and their structural

CLR-3 :

features

CLR-4 : Provide basic understanding about the biomolecules

Course

Learning 1

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Duration (hour) 12 12 12 12 12 Amino acids: acid base properties,

isoelectric point, Nucleic acids: SLO-1 separation, Niacin and its role in Classification of Classification of enzymes nucleosides and resolution of redox reactions carbohydrates nucleotides racemic mixtures of amino acids S-1 Amino acids: acid base properties,

isoelectric point, Nucleic acids: SLO-2 separation, Niacin and its role in Classification of Classification of enzymes nucleosides and resolution of redox reactions carbohydrates nucleotides racemic mixtures of amino acids asymmetric synthesis Peptide bonds: configuration, peptide enzyme catalysis and mechanisms for pyridine conformation of sugar- SLO-1 redox reactions of secondary kinetics nucleotide coenzymes phosphate backbone monosaccharides structures and their stabilization S-2 asymmetric synthesis Peptide bonds: configuration, peptide enzyme catalysis and mechanisms for pyridine conformation of sugar- SLO-2 redox reactions of secondary kinetics nucleotide coenzymes phosphate backbone monosaccharides structures and their stabilization hydrogen bonding by strategies for flavin adenine nucleophilic, acid, base bases. the double helix, Kiliani Fischer S-3 SLO-1 peptide dinucleotide and flavin and metal-ion catalysis A, B, and Z double synthesis synthesis mononucleotide helices

51 M.Sc.Organic Chemistry Duration (hour) 12 12 12 12 12 hydrogen bonding by automated flavin adenine nucleophilic, acid, base bases. the double helix, Kiliani Fischer SLO-2 peptide dinucleotide and flavin and metal-ion catalysis A, B, and Z double synthesis synthesis mononucleotide helices Proteins mechanisms for flavin SLO-1 the catalytic triad stability of double helix Ruff degradation strucutre nucleotide coenzymes S-4 Proteins mechanisms for flavin SLO-2 the catalytic triad stability of double helix Ruff degradation strucutre nucleotide coenzymes thiamine pyrophosphate primary, mechanisms of and its role in the hemiacetals of SLO-1 Replication secondary carboxypeptidase A pyruvate decarboxylase monosaccharides mechanism S-5 thiamine pyrophosphate primary, mechanisms of and its role in the hemiacetals of SLO-2 Replication secondary carboxypeptidase A pyruvate decarboxylase monosaccharides mechanism biotin and its role in the Tertiary cyclic structure of SLO-1 serine proteases pyruvate decarboxylase Transcription structure monosaccharides system S-6 biotin and its role in the Tertiary cyclic structure of SLO-2 serine proteases pyruvate decarboxylase Transcription structure monosaccharides system quaternary SLO-1 lysozyme pyridoxal phosphate Translation Glycosides structures S-7 quaternary SLO-2 lysozyme pyridoxal phosphate Translation Glycosides structures protein its role in SLO-1 enzyme inhibition DNA intercalators anomeric effect denaturation decarboxylation S-8 protein its role in SLO-2 enzyme inhibition DNA intercalators anomeric effect denaturation decarboxylation chemical synthesis of natural βamino SLO-1 .drug design Transamination DNA, catalytic RNA, Reducing sugars acids siRNA, micro RNA S-9 chemical synthesis of natural βamino SLO-2 .drug design Transamination DNA, catalytic RNA, Reducing sugars acids siRNA, micro RNA synthesis and enzymes in organic racemization of amino non-reducing SLO-1 β-peptides applications of unnatural synthesis acids sugars nucleosides S-10 synthesis and enzymes in organic racemization of amino non-reducing SLO-2 β-peptides applications of unnatural synthesis acids sugars nucleosides fluorescently labeled β-turn SLO-1 Antibody introduction C-C bond cleavage nucleosides and disaccharides peptidomimetics oligonucleotide probes S-11 fluorescently labeled β-turn SLO-2 Antibody introduction C-C bond cleavage nucleosides and disaccharides peptidomimetics oligonucleotide probes β-lactam based peptidomimetics. antibody catalyzed α, β-elimination of C-C microarray based DNA SLO-1 polysaccharides organic reactions bond detection S-12 β-lactam based antibody catalyzed α, β-elimination of C-C basics of peptide nucleic SLO-2 peptidomimetics. polysaccharides organic reactions bond acids

1. P. Y. Bruice, Organic Chemistry, 5th Ed., Pearson, 2014. 2. D. V. Vranken and G.A. Weiss, Introduction to Bioorganic Chemistry and Chemical Biology, 1st Ed., Garland Science, 2012. Learning 3. T. K. Lindhorst, Essentials of Carbohydrate Chemistry and Biochemistry, 3rd Ed., Wiley 2007. Resources 4. N. Sewald and H.D Jakubke, Peptides: Chemistry and Biology, 2ndEd. Wiley, 2009.

Continuous Learning Assessment (50% weightage) Final Examination (50% weightage)

52 M.Sc.Organic Chemistry Bloom’sLevel of CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Experts from Industry Expert from Higher Technical Institutions Internal Experts 1. Prof. G. Sekar, Department of Chemistry, IIT Madras Dr. Ravikiran Allada, Head R&D, Analytical, 1. Dr. M. R. Ganesh, SRMIST Novugen Pharma, Malaysia Email: [email protected] Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru Centre for Advanced Scientific Research 2. Dr. Gopal Chandru Senadi, SRMIST (JNCASR), Bengaluru Email: [email protected]

======

Course Course Course L T P C POC21303T Medicinal Chemistry and Drug Design C Professional Core Course Code Name Category 3 1 0 4

53 M.Sc.Organic Chemistry

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

CLR-1 : gain exposure to the field of medicinal chemistry 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 gain insight about the drug molecules, their action and CLR-2 : how to design a drug molecule gain knowledge about the structural importance in activity CLR-3 : and how to improve their water solubility learn about the use of computational simulation for drug CLR-4 :

design

know how drug molecules passes through the

CLR-5 :

membrane, their metabolism, production and formulation

(Bloom)

CLR-6 : learn strategies for the synthesis of drug molecules

Competence

Course

Learning 1

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Multicultural ICTSkills Learning Long Life CLO-1 : Understand the concept of medicinal chemistry 2 75 60 H H H L H H M H H L H H H H H CLO-2 : Realize how the drug molecules are designed 2 80 70 H H L H L L M L L H H L H H H CLO-3 : Know how the drug molecules are delivered in the cells 2 70 65 H H H M L L H L L H H L H H H Utilize computational simulation to identify a potential drug CLO-4 : 2 70 70 H L H H H L H L L H H L H H H molecule CLO-5 : Gain knowledge of drug metabolism and how to avoid it 2 80 70 L H L M L H H L L H H L H H H Acquire insight about the industrial drug production and CLO-6 : 2 75 70 H H H H H H H H H H H H H H H formulation

Duration 12 12 12 12 12 (hour) introduction and definition of structure–activity the design of combinatorial factors that affect SLO-1 drug discovery: history medicinal relationship of drugs syntheses metabolism chemistry S-1 secondary general general stages in drug changing size and pharmacological SLO-2 techniques terminologies discovery shape implications of metabolism structure and phase I metabolic introduction of new SLO-1 functions of lead discovery solid support method reactions, and substituents proteins examples S-2 structure and phase II metabolic changing of existing SLO-2 functions of desirable properties encoding methods reactions, and substituents proteins examples structure and methods and routes of changing of existing combinatorial synthesis in SLO-1 functions of prodrugs administration substituents solution nucleic acid S-3 structure and drug synthesis: sources of leads and combinatorial synthesis in SLO-2 functions of case study Some general drugs solution nucleic acid considerations, SLO-1 S-4 Tutorial Tutorial Tutorial Tutorial Tutorial SLO-2 enzyme quantitative asymmetry in SLO-1 structure and classification of drugs structure–activity high-throughput screening syntheses catalysis relationship (QSAR) S-5 quantitative inhibition in drug stereochemistry and library generation and asymmetry in SLO-2 structure–activity discovery drug design analysis syntheses relationship (QSAR) importance of water reversible molecular modeling designing organic SLO-1 solubility, and structure plasma membrane inhibitors methods syntheses S-6 of the solute irreversible methods of improving designing organic SLO-2 molecular mechanics plasma membrane inhibitors water solubility syntheses salt formation, partial organic transition-state different processes of drug S-7 SLO-1 formulation, molecular dynamics synthesis of inhibitors transfer effect of pH xenobiotics

54 M.Sc.Organic Chemistry Duration 12 12 12 12 12 (hour) surfactants and Docking: de novo effect of drug on plasma Chemical SLO-2 case studies amphiphiles design membrane development SLO-1 S-8 Tutorial Tutorial Tutorial Tutorial Tutorial SLO-2 DNA Interactive comparing 3D SLO-1 agents and drug action introduction and bioassay case study structures and use chemotherapy S-9 dereplication, structural DNA binding pharmacodynamics and pharmacological SLO-2 pharmacophores and analysis of the isolated agents pharmacokinetics testing substance active compound intercalation and use of toxicological SLO-1 drug targets: action sites development, extraction alkylation pharmacophore testing procedures S-10 DNA strand modeling protein formulation SLO-2 enzymes fractionation methods breakers structures development working three-dimensional SLO-1 receptors proteins fractionation methods production principle QSAR S-11 other uses of case studies:the story of SLO-2 case studies carrier proteins computers in drug quality control Taxol discovery SLO-1 S-12 Tutorial Tutorial Tutorial Tutorial Tutorial SLO-2

6. Gareth Thomas, Medicinal Chemistry: An Introduction, 2nd Ed., John Wiley and Sons, Ltd. Learning 7. Richard B. Silverman and Mark W. Holladay, The Organic Chemistry of Drug Design and Drug Action, 3rd Ed., Elsevier. Resources 8. Thomas Nogrady and Donald F. Weaver, Medicinal Chemistry: A Molecular and Biochemical Approach, 3rd Ed., Oxford University Press, Inc.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru Centre

for Advanced Scientific Research (JNCASR), 2. Dr. P. Gopinath, SRMIST Bengaluru Email: [email protected]

Course Course Supramolecular Chemistry and Crystal Course L T P C PCY21D05T D Discipline Elective Course Code Name Engineering Category 3 1 0 4

55 M.Sc.Organic Chemistry Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

enable them to learn the underlying principles of CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 supramolecular chemistry Strengthen the knowledge of the students in CLR-2 : supramolecular chemistry explore noncovalent interactions to form supramolecular CLR-3 : assembly. get a significant exposure in emerging field crystal CLR-4 : engineering

Express their capabilities to find applications in molecular

CLR-5 :

devices including smart actuators and molecular switches

Strengthen the skill in the area of supramolecular

CLR-6 :

chemistry to achieve suitable applications.

Course

Thinking (Bloom) Thinking

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life Understand the basic principles of supramolecular CLO-1 : 2 75 60 H H H L H H M H H L H H H H H chemistry Acquaint students with the fundamental concepts of CLO-2 : 2 80 70 H H L H L L H L L H H L H H H Molecular recognitions in supramolecular chemistry Gain knowledge about various noncovalent interactions to CLO-3 : 2 70 65 H H H M L L H L L H H L H H H form supramolecular assemblies CLO-4 : Understand the concept of crystal engineering 2 70 70 H L H H H L M L L H H L H H H CLO-5 : Gain knowledge about the Host-guest chemistry 2 80 70 L H L M L H H L L H H L H H H Acquaint students with the understanding of designing CLO-6 : tailored molecules and crystals for appropriate 2 75 70 H H H H H H H H H H H H H H H applications.

Duration (hour) 12 12 12 12 12 Terminology and Self-assembly of molecules: nomenclature in Basic understanding of Basic understanding Molecular SLO-1 Design, synthesis and supramolecular Host-guest chemistry of crystal engineering electronic devices properties of the molecules chemistry S-1 Terminology and Self-assembly of molecules: nomenclature in Synthesis and structure of Basic understanding Molecular SLO-2 Design, synthesis and supramolecular crown ethers of crystal engineering electronic devices properties of the molecules chemistry Role of H-bonding, Definition of Self-assembly of molecules: Synthesis and structure of halogen bonding and Molecular wires SLO-1 supramolecular Design, synthesis and crown ethers other weak and rectifiers chemistry properties of the molecules interactions S-2 Various Role of H-bonding, Self-assembling by H- examples of lariat ethers, podands, halogen bonding and bonding, metal-ligand Molecular wires SLO-2 supramolecular cryptands other weak interactions and other weak and rectifiers assemblies interactions interactions Chemical Co-crystals, salts, Self-assembling by H- interactions lariat ethers, podands, polymorphs and their bonding, metal-ligand Molecular switches SLO-1 leading to cryptands physico-chemical interactions and other weak and logic gates supramolecular properties interactions assemblies S-3 Chemical Co-crystals, salts, Self-assembling by H- interactions polymorphs and their bonding, metal-ligand Molecular switches SLO-2 leading to Spherands, calixarenes, physico-chemical interactions and other weak and logic gates supramolecular properties interactions assemblies SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-4 Question Question answer Question answer SLO-2 Question answer Session Question answer Session answer Session Session Session Nature of Design of molecular Relevance of binding Cyclodextrins, cyclophanes, crystals towards supramolecular S-5 SLO-1 interactions in metallomacrocycles cryptophanes achieving targeted chemistry to mimic supramolecular applications biological systems structures

56 M.Sc.Organic Chemistry Duration (hour) 12 12 12 12 12 Design of molecular Relevance of Ion-ion, ion- Cyclodextrins, crystals towards supramolecular SLO-2 dipole cyclophanes, catenanes achieving targeted chemistry to mimic interactions cryptophanes applications biological systems Ion-ion, ion- Mechanical carcerands, and cyclodextrins as SLO-1 dipole properties of catenanes hemicarcerands enzyme mimics interactions molecular crystals S-6 Mechanical Dipole-dipole, H- carcerands, and cyclodextrins as SLO-2 properties of rotaxanes bonding hemicarcerands enzyme mimics molecular crystals Host-guest interactions, cation-pi, anion- Coordination SLO-1 pre-organization and rotaxanes ion channel mimics pi interactions polymers complementarity S-7 Host-guest interactions, cation-pi, anion- Coordination SLO-2 pre-organization and rotaxanes ion channel mimics pi interactions polymers complementarity SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-8 Question Question answer Question answer SLO-2 Question answer Session Question answer Session answer Session Session Session pi-pi and Van Metal organic supramolecular SLO-1 der Waals Lock and key analogy helicates and knots frameworks catalysis interactions S-9 pi-pi and Van Metal organic supramolecular SLO-2 der Waals Lock and key analogy helicates and knots frameworks catalysis interactions Various examples to Binding of cationic, Examples of recent Binary and Ternary supramolecular SLO-1 illustrate anionic, ion pair and developments in cocrystals catalysis noncovalent neutral guest molecules. supramolecular chemistry. interactions S-10 Various examples to Binding of cationic, Examples of recent Binary and Ternary supramolecular SLO-2 illustrate anionic, ion pair and developments in cocrystals catalysis noncovalent neutral guest molecules. supramolecular chemistry. interactions Supramolecular Various examples to Examples of recent assemblies for Various applications Question answer SLO-1 illustrate noncovalent developments in various of crystal engineering Session interactions supramolecular chemistry. applications S-11 Supramolecular Various examples to Examples of recent assemblies for Various applications Question answer SLO-2 illustrate noncovalent developments in various of crystal engineering Session interactions supramolecular chemistry applications SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-12 Question Question answer Question answer SLO-2 Question answer Session Question answer Session answer Session Session Session

1. J.M. Lehn, Supramolecular Chemistry-Concepts and Perspectives, Wiley-VCH, 1995. 2. P. D. Beer, P. A. Gale and D. K. Smith, Supramolecular Chemistry, Oxford University Press, 1999. 3. J. W. Steed and J. L. Atwood, Supramolecular Chemistry, 1st Ed., Wiley, 2000. Learning 4. J. W. Steed, Core Concepts in Supramolecular Chemistry and Nanochemistry,1stEd., John Wiley & Sons, 2007. Resources 5. J.D. Seader, I. W. Hamley, Introduction to soft mater Synthetic and Biological self-assembly materials, Separation process principles,2nd Ed., Wiley, 2010. 6. G. R. Desiraju, J. J. Vittal and A. Ramanan, Crystal Engineering: A Textbook, World Scientific, 2011.

57 M.Sc.Organic Chemistry Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru

Centre for Advanced Scientific Research Dr. Priyadip Das, SRMIST (JNCASR), Bengaluru Email: [email protected]

======

58 M.Sc.Organic Chemistry

Course Course Course L T P C POC21D03T Organometallic Chemistry and Catalysis D Discipline Elective course Code Name Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

identify the structure and bonding aspects of simple CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 organometallic compounds. understand of structure-reactivity correlation of transitional CLR-2 : metal complexes be familiar with synthesis of transition metal complexes CLR-3 : and their uses

gain knowledge of transition metal catalyzed C-H

CLR-4 :

activation reactions and their applications

CLR-5 : understand different type of catalytic reactions

CLR-6 : learn about the suitable applications of organocatalysis

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life CLO-1 Identify the geometry of the organometallic complexes 2 75 60 H H H L H H M H H L H H H H H : CLO-2 Synthesize of a few coupling reactions with the basic 2 80 70 H H L H L L H L L H H L H H H : knowledge of reaction mechanism CLO-3 Synthesize of new organometallic compounds using Rh/Ir 2 70 65 H H H M L L H L L H H L H H H : catalyzed C-H activation reactions CLO-4 To apply RhCl3 in ethylene dimerization reactions 2 70 70 H L H H H L M L L H H L H H H : CLO-5 To apply Ziegler-Natta catalyst for the synthesis of straight 2 80 70 L H L M L H H L L H H L H H H : chain polymers CLO-6 To utilize organocatalysis during synthesis of novel 2 75 70 H H H H H H H H H H H H H H H : compounds

Duration (hour) 12 12 12 12 12 Metal (Fe, Pd) ene, Type of ligands, π Complexes of Introduction to SLO-1 dieneand dienyl Introduction to catalysis 18 electron rule unsaturated molecules organocatalysis complexes S-1 Transition metal π Complexes of Catalysis of Lewis SLO-2 carbonyl Dienyl complexes Homogeneous catalysis unsaturated molecules base complexes Synthesis of transitional Hydrogenation, catalysis of Substitutes for Metal complexes as SLO-1 metal complexes with Hydroformylation Bronsted acid and carbonyl ligands protecting groups alkenes base S-2 Synthesis of Activation towards catalysis of Non-carbon cyclopentadienyl, Acetic acid synthesis SLO-2 nucleophilic addition Bronsted acid and ancillary ligands cycloheptatriene reaction base complexes Synthesis of Rules governing Catalysis of Ligand substitution Heterogeneous catalysis SLO-1 benzenoid, π-allyl, and nucleophilic additions, iminium, enamine, reactions enyl systems synthetic utility. examples S-3 Pd, Ni and Fe Ligand insertion structure, bonding and complexes, synthesis Carbenes as SLO-2 Heterogeneous catalysis reactions reactivity of complexes and their synthetic organocatalysts utility. SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-4 Question answer Question answer Question answer Question answer SLO-2 Question answer Session Session Session Session Session carbene Various Wacker type Types of different SLO-1 Metathesis reactions Fischer-Tropsch reaction complexes oxidation NHCs and their synthesis S-5 Cyclization reactions Transition metal Migratory insertion NHC catalysed SLO-2 including asymmetric Fischer-Tropsch reaction organometallics reaction with alkynes umpolung version. reactions

59 M.Sc.Organic Chemistry Duration (hour) 12 12 12 12 12 square planar C – C single bond Metal (Co, Zr) alkyne Ziegler-Natta polymerization Trans-esterification SLO-1 complexes formation reactions complexes reactions, S-6 Homo and cross Oxidative addition, Protection of triple SLO-2 Metal alkyls Ziegler-Natta polymerization benzoin type Transmetallation bond reactions C-C bond forming Olefin oxidation, Reductive elimination, reactions e.g. Stetter reaction, SLO-1 Metal alkylidenes Isomerisation, Insertion reaction Pauson-Khand Enolate chemistry

reaction S-7 Alkyne Metal alkylidynes, β-hydride and alkyl cyclotrimerization, Addition of HX to olefins Homoenolate SLO-2 and metal arenes elimination reactions Oligomerization derived reactions reaction SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-8 Question answer Question answer Question answer Question answer SLO-2 Question answer Session Session Session Session Session Metal (Cr, Fe, Ru) Reactions involving Addition to ketenes arene complexes, Carbonyl insertion SLO-1 Vaskas complex organo-copper and and analogs synthesis and palladium intermediates S-9 structure. Activation of arene Reactions involving Hydride elimination Addition to ketenes SLO-2 Applications nucleus and side other transition metals and analogs chain. Suzuki coupling Nucleophilic SLO-1 Abstraction Oxidative NHC S-10 Isolobal analogy reactions with substitution and catalysis SLO-2 mechanism addition of arene. Fluxional Metal (Rh, Ir) Cooperative Stille coupling reactions SLO-1 properties of catalyzed C-H Cyclooligomerisation catalysis, metal with mechanism organometallics. activation reactions catalysts S-11 Fluxional Negishi and Ullman Ethylene dimerization using Other SLO-2 properties of coupling reactions with Their synthetic utility RhCl3 as catalyst. organocatalysts organometallics mechanism SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session

S-12 Question answer Question answer Question answer Question answer SLO-2 Question answer Session Session Session Session Session

1. M. Weller, T. Overton, J. Rourke and F. Armstrong, Inorganic Chemistry, 6th Edition, Oxford University Press, 2014. (South Asia Edition 2015) 2. E. Huheey, E. A. Keiter, R.L. Keiter and O. K. Mehdi, Inorganic Chemistry, Principles of Structure and Reactivity, 4th Edition, Pearson, 2006. 3. D. Gupta and A. J. Elias; Basic Organometallic Chemistry: Concepts, Synthesis, and Applications, 2nd Edition, Universities Press Learning (India), 2013. Resources 4. P Powell, Principles of organometallic Chemistry, 2nd Edition, Springer, 2009. 5. D. Astruc, Organometallic Chemistry and Catalysis, Springer Verlag, 2007. 6. M. Schlosser, Organometalllics in Synthesis, A manual, John Wiley, New York, 1996. 7. L. S. Hegedus, Transition metals in the synthesis of complex organic molecules, second edition, University Science, Book, CA, 1999. 8. D. Astruc, Organometallic Chemistry and Catalysis, Springer Verlag, 2007.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

60 M.Sc.Organic Chemistry

Course Designers Experts from Industry Expert from Higher Technical Institutions Internal Experts 1. Prof. G. Sekar, Department of Chemistry, IIT Madras 1. Dr. Palash Sanphui, SRMIST Dr. Ravikiran Allada, Head R&D, Analytical, Email: [email protected] Novugen Pharma, Malaysia Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru

Centre for Advanced Scientific Research 2. Dr. Gopal Chandru Senadi, SRMIST (JNCASR), Bengaluru Email: [email protected]

======

61 M.Sc.Organic Chemistry

Course Course Course L T P C POC21D04T Industrial Organic Chemistry D Discipline Elective Course Code Name Category 3 1 0 4

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

provide a general understanding of the field of modern CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 industrial organic chemistry CLR-2 : learn about oil refinery processes from crude oil CLR-3 : gain knowledge of useful gases industrially. acquire knowledge on synthesis of polymers and their CLR-4 :

various applications

CLR-5 : synthesize natural products in a controlled manner

learn the systematic synthetic procedure of essential

CLR-6 :

medicine and process thereof

Course

Learning

1 2

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life CLO-1 : be familiar with the Process Chemistry in an Industry 2 75 60 H H H L H H M H H L H H H H H Think practically about the industrial output of laboratory CLO-2 : 2 80 70 H H L H L L H L L H H L H H H methods of synthesis. CLO-3 : Understand the processes involved in oil refinery. 2 70 65 H H H M L L H L L H H L H H H CLO-4 : Synthesize important derivatives of aromatic compounds 2 70 70 H L H H H L M L L H H L H H H Understand the importance of biodegradable plastics and CLO-5 : 2 80 70 L H L M L H H L L H H L H H H its importance. CLO-6 : Design synthesis of natural products and essential drugs 2 75 70 H H H H H H H H H H H H H H H

Duration (hour) 12 12 12 12 12 Oil refinery Chemicals from Benzene, Polymer - Process chemistry SLO-1 physical Carbohydrates. Toluene and Xylene Introduction. – introduction processes S-1 Molecular weights of Desalting and Review of electrophilic Process chemistry SLO-2 polymer, Lipids, oils and fats. dehydration substitution reactions – introduction preparations Crude Phenol-formaldehyde Free radical Properties of a SLO-1 Amino acids. distillation. resins polymerization drug Primary raw cardiovascular S-2 materials from Reduction of benzene to Acid-catalyzed Fine chemicals such as drugs, SLO-2 petroleum and cyclohexane polymerization advanced intermediates (atorvastatin, natural gas rosuvastatin) Liquid fuels - Oxidation to adipic acid Drugs affecting the SLO-1 Ziegler-Natta process Pesticides, vitamins Petroleum (nylon 6,6 and nylon 6) nervous system Cracking -Steam Caprolactam from S-3 Barbiturates, cracking: cyclohexanone oxime, Flavor and fragrance SLO-2 Copolymerization psychotropic production of Beckmann chemicals drugs, stimulants lower alkenes. rearrangement SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-4 Question Question answer Question answer SLO-2 Question answer Session Question answer Session answer Session Session Session Advantages of Reactions of toluene, catalytic Living polymers, Process Chemistry: Batch antibacterial SLO-1 benzyl chloride, benzoic cracking over block polymers reactor design. agents acid and benzaldehyde S-5 thermal cracking Synthetic Petrol, sulfonamides, Xylene to phthalic Stereoregular Fermentation technology-cell SLO-2 Octane and penicillins, anhydride (plasticizers). polymers biomass cetane numbers cephalosporins Syndiotactic, Production of Chemicals from Acetylene, Bakers ́ yeast production tetracyclines, SLO-1 isotactic, atactic gasoline, diesel Addition reactions. from sugars macrolides polymers S-6 Production of Reactions of acetylene; Plastics, Moulding steroid drugs (oral liquid petroleum SLO-2 trichloromethylene techniques, Triglycerides. contraceptives, gas (LPG), (degreasing), Fabricating methods sex hormones) compressed

62 M.Sc.Organic Chemistry Duration (hour) 12 12 12 12 12 natural gas perchloroethylene (dry (CNG). cleaning). Hard tough plastics, MTBE and Synthesis of Gases, high density Adrenocortical ETBE Ammonia (Haber SLO-1 polyethylene, Fat industrial extraction hormones, production Process), Carbon polypropylene, anabolic agents routes Monoxide. S-7 polystyrene Use of zeolites Nylon, polyvinyl for shape Saponification. Fat anti-inflammatory SLO-2 Coal-tar chemicals chloride, phenol- selectivity in the hydrogenation. agents formaldehyde resins oil refinery. SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-8 Question Question answer Question answer SLO-2 Question answer Session Question answer Session answer Session Session Session Chemicals from Soft weak plastics, Analgesics SLO-1 Ethylene, Fischer-Tropsch reaction low density Detergents and surfactants. (aspirin, Propylene. polyethylene acetaminophen) Addition S-9 Elastomers reactions; (Rubbers), SLO-2 conversion to Fischer-Tropsch reaction Trans esterification. Anti-histamines Discussion on acrolein and polyisoprenes acrylonitrile Synthesis of cumene natural rubber, Enzyme technology SLO-1 hydroperoxide; Fats and oils, fatty acids styrene-butadiene (biocatalysts for chemical Anti-cancer agents phenol and rubber transformations). S-10 acetone. Chemicals from Synthetic natural Semisynthetic SLO-2 Alcohols, carbohydrates, Production of L-Amino acids. the C4 Stream. rubber route of Taxol Fiber reinforced Production of artificial Synthesis of SLO-1 Butadiene Starch, Cellulose plastics, Applications sweeteners antidiabetic drugs S-11 Diels-Alder Metformin, Biodegradable D-mannitol, acesulfame, SLO-2 reaction; 1,4- Natural gums sitagliptin, plastics. saccharin. additions. canagliflozin SLO-1 Tutorial Session Tutorial Session Tutorial Session Tutorial Session Tutorial Session S-12 Question Question answer Question answer SLO-2 Question answer Session Question answer Session answer Session Session Session

1. Philip J. Chenier, Survey of industrial chemistry, 2nd Revised Edition, VCH, New York 1992, ISBN 1‐527‐28186‐X 2. Mohammad F. Ali, Bassam M. El Ali, James G. Speight, Handbook of Industrial Chemistry: Organic Chemicals 2005 McGraw- Hill Education, ISBN: 9780071410373. 3. Harold A. Wittcoff, Industrial Organic Chemicals in Perspective, 1992, Krieger Publishing ISBN-10 : 0894643894 Learning 4. H. Harry Szmant, Organic Building Blocks of the Chemical Industry, 1989, Wiley-Interscience; 1st edition, ISBN: 978-0-471- Resources 85545-3. 5. Weissermel, K.; Arpe, H.-J. Industrial organic chemistry. 4th completely rev. ed. Weinheim [etc.]: Wiley-VCH, 2003. ISBN9783527305780. 6. Moulijn, J. A.; Makkee, M.; Diepen, A. van. Chemical process technology [on line]. 2nd ed. Chichester: Wiley, 2013.

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

63 M.Sc.Organic Chemistry Course Designers Experts from Industry Expert from Higher Technical Institutions Internal Experts 1. Prof. G. Sekar, Department of Chemistry, IIT Madras Dr. Ravikiran Allada, Head R&D, Analytical, 1. Dr. Baburaj Baskar, SRMIST Email: [email protected] Novugen Pharma, Malaysia

Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru Centre

for Advanced Scientific Research (JNCASR), 2. Dr. Palash Sanphui, SRMIST Bengaluru Email: [email protected]

======

64 M.Sc.Organic Chemistry

ourse PPY21G01T Course Energy Storage and Devices Course G Generic Elective Course L T P C Code Name Category 3 0 0 3

Pre- Nil Co- Nil Progressive Nil requisite requisite Courses Courses Courses Course Physics and Data Book / Codes/Standards Nil Offering Nanotechnology Department

Course The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Learning Rationale (CLR): CLR-1: provides basic knowledge in the multidisciplinary field of energy 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 storage devices and their applications

CLR-2: manage basic principles for accessible and relevant energy

storage systems qualitatively.

CLR-3: learn concept and operation of available and relevant energy

storage systems

CLR-4: identify different needs within energy storage.

CLR-5: cause of efficiency losses in various energy storage systems

CLR-6: identify available technologies and materials for energy storage and Knowledge

their application areas

2 3

Level of Thinking (Bloom) of Thinking Level

- - - Directed Learning Directed

Course Learning Outcomes (CLO): At the end of this course, learners will -

be able to:

Expected Proficiency (%) Proficiency Expected Attainment (%) Expected Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Reasoning Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life PSO PSO PSO CLO-1: understand the basic concepts of energy storage devices. 2 80 75 H H H H H H H H H H M H H H H CLO-2: gain the knowledge of electrochemical energy storage devices. 2 80 70 H H H H H H H H H H M H H H H CLO-3: realize the applications of magnetic and electric energy storage 2 75 70 H H H H H H H H H H M H H H H system CLO-4: know about the fuel cell based energy storage system 2 80 75 H H H H H H H H H H M H H H H CLO-5: understand the basic concepts of hydrogen production and storage 2 80 70 H H H H H H H H H H M H H H H CLO-6: understand the concept and operation of available and relevant 2 80 75 H H H H H H H H H H M H H H H energy storage systems.

Duration 9 9 9 9 9 (hour) S- SLO- Definition and units Electrochemical energy Magnetic and Electric Basics Fuel cell Hydrogen production- 1 1 of energy and power storage-Battery energy storage system definition From fossil fuels SLO- Definition and units Superconducting Difference between Electrolysis 2 of conservation of Magnetic Energy batteries and fuel cells energy Primary Batteries Storage (SMES) S- SLO- Definition of Second Capacitors and Fuel cell history Thermal 2 1 law of Batteries decomposition thermodynamics Secondary Batteries SLO- Explanation of Lithium Batteries Comparison and Components of fuel Thermal 2 Second law of application cells decomposition thermodynamics S- SLO- PROBLEM Solving Simple numerical PROBLEM Solving on Assignment to cover Simple exercise on 3 1 on Energy and problem capacitors and the history of fuel cell Electrolysis Power On Electrochemical batteries energy storage SLO- PROBLEM Solving Simple numerical PROBLEM Solving on Assignment to cover Simple exercise on 2 on Second law of problem capacitors and the history of fuel cell Electrolysis thermodynamics On Electrochemical batteries energy storage S- SLO- Energy resources Solid state Batteries Super capacitor Principle of working of Photochemical 4 1 fuel cell SLO- Energy storage Molten solvent Super capacitor Advantages and Photo catalytic 2 Batteries Disadvantages of fuel cell power plant S- SLO- Need of energy Electrochemical double Fuel cell types-Alkaline Hybrid storage 5 1 storage Lead Acid Batteries layer capacitor (EDLC) fuel cell SLO- Different modes of Principle of working of Polymer electrolyte fuel Hybrid storage 2 energy storage- Nickel cadmium EDLC cell Capacitors Batteries S- SLO- PROBLEM Solving Assignment on Solid Assignment on EDLC Seminar related to Assignment on 6 1 on capacitors state battery various fuel power Hydrogen storage plants in India

65 M.Sc.Organic Chemistry SLO- PROBLEM Solving Assignment on Solid Assignment on EDLC Seminar related to Assignment on 2 on capacitors state battery various fuel power Hydrogen storage plants in India S- SLO- Electrochemical Advanced Batteries Structure, Performance Phosphoric acid fuel Metal hydrides 7 1 energy storage of EDLC cell SLO- Electrical energy Advanced Batteries Applications of EDLC Molten carbonate fuel Metallic alloy hydrides 2 storage cell S- SLO- Magnetic and , Role of Carbon Nano- Role of activated Solid oxide fuel cell Carbon Nano-tubes 8 1 Chemical energy tubes in electrodes Carbon storage SLO- Hydrogen for energy Role of Carbon Nano- Role of Carbon Nano- Problems with fuel, Sea as the source of 2 storage tubes in electrodes tubes Applications of fuel deuterium cells S- SLO- Assignment on Simple activity related Student seminar Assignment on Acid Student seminar 9 1 Electrochemical to advanced batteries related to CNT and Oxide fuel cell related to Deuterium energy storage SLO- Assignment on Simple activity related Student seminar Assignment on Acid Student seminar 2 Electrochemical to advanced batteries related to CNT and Oxide fuel cell related to Deuterium energy storage

Learning 1. R.A. Huggins, Energy Storage, 1st Ed., Springer, 2010. 4. Srinivasan, Fuel Cells from Fundamentals to Resources 2. J.-M. Tarascon, and Patrice Simon, Electrochemical Energy Applications, 1st Ed., Springer, 2006. Storage, 1st Ed., Wiley, 2015. 5. Basile, A. Iulianelli, Advances in Hydrogen 3. F. Díaz-González, A. Sumper and O. Gomis-Bellmunt, Energy Production, 1st Ed., Storage and Distribution, storage in power systems, 1st Ed., Wiley, 2016. Woodhead Publishing, 2014. 6. N. Kularatna, Energy Storage Devices for Electronic Systems: Rechargeable Batteries and Supercapacitors, Academic Press, 2014.

Learning Assessment Bloom’s Continuous Learning Assessment (50% weightage) Final Examination (50% Level of CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# weightage) Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Level Remember 30 % - 30 % - 30 % - 30 % - 30 % - 1 Understand Level Apply 40 % - 40 % - 40 % - 40 % - 40 % - 2 Analyze Level Evaluate 30 % - 30 % - 30 % - 30 % - 30 % - 3 Create Total 100 % 100 % 100 % 100 % 100 % # CLA – 4 can be from any combination of these: Assignments, Seminars, Scientific Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications etc.,

Course Designers Experts from Industry Experts from Higher Technical Institutions Internal Experts Dr. DK Aswal, National Physical Laboratory (NPL), Prof. VS Subramanian, IIT Madras, Dr. Kamalabharathi [email protected] [email protected] Dr. V Subramanian, CLRI, [email protected] Prof. S Balakumar, University of Madras, Dr. Gunasekran [email protected]

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66 M.Sc.Organic Chemistry

Course PPY21G03T Course LASER Physics Course G Generic Elective Course L T P C Code Name Category 3 0 0 3

Pre- Nil Co- Nil Progressive Nil requisite requisite Courses Courses Courses Course Physics and Data Book / Codes/Standards Nil Offering Nanotechnology Department

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR): CLR-1: comprehend the principles of nanotechnology. 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 CLR-2: make the students understand the basic concepts in nanoscience.

CLR-3: develop understanding on the exotic properties of nanostructured materials.

CLR-4: introduce various techniques available for the processing of

nanostructured materials.

CLR-5: emphasize the importance and development of

nanotechnology in various fields

CLR-6: enable them to learn applications of nanotechnology in

various fields

Reasoning

2 3

Level of Thinking (Bloom) of Thinking Level

- - - Directed Learning Directed

Course Learning At the end of this course, learners will be able to: -

Outcomes (CLO):

Expected Proficiency (%) Proficiency Expected Attainment (%) Expected Knowledge Disciplinary Thinking Critical Solving Problem Reasoning Analytical Skills Research TeamWork Scientific Thinking Reflective Self Competence Multicultural ICTSkills Learning Long Life PSO PSO PSO CLO-1: understand the characteristics of a laser 2 80 75 H H H H H H H H H H M H H H H CLO-2: understand the Fabry Perot resonator towards a laser 2 80 70 H H H H H H H H H H M H H H H resonator CLO-3: understanding the rate equations to apply for lasers 2 75 70 H H H H H H H H H H M H H H H CLO-4: understand the conditions of stable resonators 2 80 75 H H H H H H H H H H M H H H H CLO-5: understand the physics of higher harmonic generation 2 80 70 H H H H H H H H H H M H H H H CLO-6: understand various types of lasers 2 80 75 H H H H H H H H H H M H H H H

Duration 9 9 9 9 9 (hour) S-1 SLO- Cavity life time and Geometrical optics Introduction to Q- General Introduction Coherence properties of 1 Quality factor analysis of optical switching to lasers laser light resonators SLO- Spontaneous and Dynamics of the Q- Condition for stable 2 stimulated emission Ultimate line width of a switching process Temporal coherence resonators Stimulated absorption laser S-2 SLO- Einstein’s A and B Stability diagram for Electro-optical Q- The laser idea Spatial coherence 1 Coefficients optical resonators switching SLO- Gain medium, Ratio of A and B at Introduction to mode Young’s double slit 2 pumping scheme and thermal equilibrium Sources of resonator locking experiment to optical feedback loss understand spatial coherence S-3 SLO- Properties of laser Mathematical Introduction to 1 beams: Laser rate equations interpretation for mode Specific laser systems resonators Monochromaticity locking SLO- Mathematical Directionality, Introduction to four level 2 Fabry-Perot cavity interpretation for mode Ruby laser coherence laser system locking S-4 SLO- Mathematical Passive mode locking 1 formulation of rate Modes of a cavity Basic apparatus He:Ne laser equations for four level laser system SLO- Mathematical Active mode locking 2 Elementary theory of formulation of rate Black body radiation Carbon dioxide laser Fabry-Perot cavity equations for four level laser system S-5 SLO- Transmission spectrum Condition for population Concept of Gain Dye lasers, Black body radiation 1 of a Fabry-Perot cavity inversion saturation semiconductor lasers SLO- Calculation of mode Coefficient of Threshold condition for Hole burning DBR lasers 2 density for black body finesse/Quality factor four level system S-6 SLO- Calculating number of Fundamental Gaussian Calculating threshold for Spatial hole burning Nd:YAG laser 1 photons beam He-Ne laser

67 M.Sc.Organic Chemistry per mode for black body SLO- Comparison of black Gaussian beam in Longitudinal and Higher harmonic Integrating cavity rate 2 body radiation with homogeneous medium transverse mode generation equation laser radiation selection S-7 SLO- Gaussian beam focusing Rate equations under Single mode operation Physics of harmonic Line shape functions 1 steady state condition generation SLO- Line-broadening Higher order Hermite Variation of laser power Multi-mode lasers Physics of harmonic 2 mechanisms Gauss beams around the threshold generation S-8 SLO- Homogeneous and Gain competition Second harmonic Analysis of higher order Optimum output 1 Inhomogeneous generation Hermite Gauss beams coupling broadening SLO- Natural, Doppler and Analysis of higher order Optical amplifiers Third harmonic Laser spiking 2 Collison broadening Hermite Gauss beams generation S-9 SLO- Problem solving Problem solving Classification of lasers Problems solving Problems solving 1 SLO- Problem solving Problem solving Laser safety Problems solving Problems solving 2

Learning 3. A. Yariv, Quantum Electronics, 3rd Ed., Resources John Wiley, New York, 1989 1. K. Thyagarajan and A.K. Ghatak, Lasers Theory and 4. Seigman, Lasers, 3rd Ed., Oxford Univ. Applications, 1st Ed., Macmilan Publishers, 2010. Press, 1986. 2. O. Svelto, Principles of lasers, 4th Ed., Springer, 1998. 5. B.E.A. Saleh and M.C. Teich, Fundamentals of Phtonics, 2nd Ed., Wiley, 2012.

Learning Assessment Bloom’s Continuous Learning Assessment (50% weightage) Final Examination (50% Level of CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# weightage) Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Level Remember 30 % - 30 % - 30 % - 30 % - 30 % - 1 Understand Level Apply 40 % - 40 % - 40 % - 40 % - 40 % - 2 Analyze Level Evaluate 30 % - 30 % - 30 % - 30 % - 30 % - 3 Create Total 100 % 100 % 100 % 100 % 100 % # CLA – 4 can be from any combination of these: Assignments, Seminars, Scientific Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications etc.,

Course Designers Experts from Industry Experts from Higher Technical Institutions Internal Experts Dr. N Vijayan, NPL, nvijayan @nplindia.org Prof. V Subramanian, IIT Madras, Dr. K Shadak Alee, [email protected] SRMIST Mr. R Seshadri, Titan Company Limited, Prof. C Vijayan, IIT Madras, [email protected] Dr. Junaid M Laskar, [email protected] SRMIST

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68 M.Sc.Organic Chemistry

Course Course Course L T P C PCY21G01T Research Skills and Learning G Generic Elective Course Code Name Category 3 0 0 3

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

CLR-1 understand the concept of research and different types 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 : of research in the context of chemistry CLR-2 evaluate the different methods of scientific writing and

: reporting CLR-3 impart the knowledge about the statistical distribution

: and applications CLR-4 develop the skill of technical writing :

CLR-5 inculcate the knowledge of intellectual property and

: rights

CLR-6

understand the important areas of research

Course

Learning 1

- - - At the end of this course, learners will be able to: Learning Directed

Outcomes -

PSO PSO PSO

(CLO): PSO

DisciplinaryKnowledge Thinking Critical Solving Problem AnalyticalReasoning Skills Research Work Team ScientificReasoning Thinking Reflective Self Competence Multicultural Skills ICT Learning Long Life Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected CLO-1 Understand the key areas of research 2 75 60 H H H L H H H H H L H H H H H : CLO-2 Develop experimental skills and documentation 2 80 70 H H L H H H H L L H H L H H H : CLO-3 Develop competence on data collection and process of 2 70 65 H H M M H L H L L H H L H H H : scientific documentation CLO-4 Understand the research ethics 2 70 70 H L H H H L M L L H H L H H H : CLO-5 Submit proposals for funding agencies 2 80 70 H H H M M H H L L H H L H H H : CLO-6 Understand the key areas of research 2 75 70 H H H H H H H H H H H H H H H :

Duration 9 9 9 9 9 (hour) Objectives of Analysis and Technical writing Ethics in research SLO-1 Online databases research Presentation of Data S-1 Research methods Activity in Technical writing authors E-journals, Journal SLO-2 and methodologies- Descriptive statistics Acknowledgement acces Overview types of research- Technical presentation Group discussion on Citation index, Impact Choosing and using SLO-1 Descriptive vs ethics in research factor, statistical tests analytical S-2 types of research - Activity in Technical Outcome of group Sample test – SLO-2 applied vs H-index, E-consortium presentation discussion Student –t –test fundamental types of research- Creativity in research – Basic Plagiarism SLO-1 quantitative vs UGC infonet, E-book F- test idea qualitative S-3 types of research- Creativity in research - Activity Tools to avoid SLO-2 conceptual vs Preprint servers κ2 test plagiarism empirical Literature-review Good practicals – Units, Presentations - Search engines, Scirus, SLO-1 Chemometrics numbers Power-point Google Scholar S-4 presentation. Consolidation of ChemIndustry, Wiki- Analysis of variance Reproducibility Poster presentation SLO-2 Literature-review Databases (ANOVA), Sources of Scientific writing - Elements of excellent ChemSpider, Science Correlation and SLO-1 information Abbreviations presentation Direct regression S-5 Primary, secondary, nomenclature Communication skills SLO-2 tertiary sources SciFinder, Scopus Curve fitting

69 M.Sc.Organic Chemistry Duration 9 9 9 9 9 (hour) Journal justification for scientific Activity based on Internet resources for fitting of linear SLO-1 abbreviations, contributions research Science equations, abstracts, presentation S-6 reviews, description of methods Activity based on SLO-2 monographs, Library research, analysis of residuals research dictionaries presentation Introduction to conclusions Proposal submission General polynomial SLO-1 Chemical field research for funding agencies fitting S-7 Abstracts Laboratory research linearizing the need for illustration, style Knowledge of SLO-2 Author Index transformations funding agencies Data Analysis – Making Writing references Intellectual property exponential function SLO-1 Formula Index and Recording fit, Measurements S-8 Data Analysis – Making Research report writing Intellectual property SLO-2 Subject Index and Recording r and its abuse rights Measurements Basic aspects of Copy rights Maintaining a laboratory Activity based on scientific SLO-1 Substance Index multiple linear record writing regression analysis S-9 Tabulation and generation Basic aspects of Patent rights other Indices with Activity based on scientific SLO-2 of graphs multiple linear examples writing regression analysis

1. Dawson, C.. Practical research methods. UBS Publishers, New Delhi, 2002 Learning 2. Walpole R.A., Myers R.H., Myers S.L.and Ye King: Probablity and statstics for engineers and scientist, Pearson Prentice Resources Hall, Pearson Education, Inc. 2007 3. 3. Kothari C.K., Research Methodology-Methods and Techniques(New Age International, New Delhi), 2004

Continuous Learning Assessment (50% weightage) Bloom’sLevel of Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 30% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 50% - 50% - 50% - 50% - Analyze Evaluate Level 3 30% - 20% - 20% - 20% - 20% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Experts from Industry Expert from Higher Technical Institutions Internal Experts 1. Prof. G. Sekar, IIT Madras, Dr. Ravikiran Allada, Head R&D, 1. Dr. T. Pushpa Malini, SRMIST Analytical, Novugen Pharma, [email protected] Malaysia 2. Prof. Vivek Polshettiwar, TIFR Mumbai, 2. Dr. J.Arockia Selvi, SRMIST [email protected] Email: [email protected]

======

70 M.Sc.Organic Chemistry

Course Course Course L T P C POC21S02L Advance Organic Chemistry Practical S Skill Enhancement Course Code Name Category 0 0 6 3

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

Practice separation techniques used in organic CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 synthesis CLR-2 : Know how isolate natural products CLR-3 : Learn orthogonal protection of functional groups

Gain practical experience about oxidation and

CLR-4 :

reduction

CLR-5 : Learn multi step synthesis

CLR-6 : Practice green chemistry

Course

Learning

1 2

3 -

At the end of this course, learners will be able to: -

- Directed Learning Directed

Outcomes -

(CLO):

Level of Thinking of (Bloom) Level (%) Proficiency Expected (%) Attainment Expected DisciplinaryKnowledge Thinking Critical Solving Problem AnalyticalReasoning Skills Research Work Team ScientificReasoning Thinking Reflective Self Competence Multicultural Skills ICT Learning Long Life PSO PSO PSO Acquire knowledge about advanced methods of CLO-1 : 2 75 60 H H H L H H M H H L H H H H H organic synthesis Learn synthetic procedures: aqueous workup, CLO-2 : distillation, reflux, separation, isolation, and 2 80 70 H H L H L L H L L H H L H H H crystallization Experience the procedure for natural product CLO-3 : 2 70 65 H H H M L L H L L H H L H H H isolation Perform multicomponent reaction and green CLO-4 : 2 70 70 H L H H H L M L L H H L H H H chemistry CLO-5 : Learn about the orthogonal protection method 2 80 70 L H L M L H H L L H H L H H H Characterize of compounds by using modern CLO-6 : 2 75 70 H H H H H H H H H H H H H H H analytical techniques

Duration 18 18 18 18 18 (hour) Distillation at SLO-1 Multistep synthesis: normal pressure: Isolation of natural Orthogonal protection Multicomponent S-1 to Cyclohexanone → Single and product: of amine and acid synthesis: Mannich 6 cyclohexanone oxime → SLO-2 mixture of caffeine from tea leaves functional groups reaction caprolactone compounds Distillation at SLO-1 reduced pressure: Green chemistry: Oxidation of alcohol: Chalcone → chalcone S-7 to Single and piperene from black Direct Oxidative Benzyl alcohol → dibromide → - 12 mixture of pepper esterification of benzyl aldehyde bromochalcone SLO-2 compounds Aldehyde

Separation using SLO-1 Reduction of carbonyl column Benzophenone → S-13 to compound: 4- Organic synthesis in chromatography- lycopene from tomatoes benzopinacol → 18 nitrobenzaldehyde → water SLO-2 melting point benzopinacolone 4-nitrobenzyl alcohol measurement

1. Vogel, A Textbook of Practical Organic Chemistry, 5th Ed., Prentice Hall. Learning 2. Fieser and Fieser, Reagents in Organic Synthesis, Wiley. Resources 3. Mann &Saunders, Practical Organic Chemistry, 4th Ed., Longmans

71 M.Sc.Organic Chemistry

Continuous Learning Assessment (50% weightage) Bloom’sLevel Final Examination (50% weightage) CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# of Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Level Remember - 30% - 30% - 30% - 30% - 30% 1 Understand Level Apply - 40% - 50% - 50% - 50% - 50% 2 Analyze Level Evaluate - 30% - 20% - 20% - 20% - 20% 3 Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

Course Designers Expert from Higher Technical Experts from Industry Internal Experts Institutions 1. Prof. G. Sekar, Department of Chemistry, IIT Madras Dr. Baskar Baburaj, SRMIST Dr. Ravikiran Allada, Head R&D, Analytical, Email: [email protected] Novugen Pharma, Malaysia Email: [email protected] 2. Dr. Kanishka Biswas, Jawaharlal Nehru Centre for Advanced Scientific Research Dr. Susnata Pramanik, SRMIST (JNCASR), Bengaluru Email: [email protected]

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72 M.Sc.Organic Chemistry Course POC21I01L Course Massive Open Online Course Course P Project Work, L T P C Code Name Category Internship In 0 0 0 2 Industry / Higher Technical Institutions

Pre- Nil Co-requisite Nil Progressive Nil requisite Courses Courses Courses Course Offering Chemistry Data Book / Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

encourage initiative by Govt. of India to 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 achieve the three cardinal principles of

CLR -1 : access, equity and quality in different

learning communities.

Learning

Course

Learning At the end of this course, learners will be able

1 2

- -

- Directed Directed

Outcomes to: -

PSO PSO PSO

(CLO): PSO

Level of Thinking of (Bloom) Level (%) Proficiency Expected (%) Attainment Expected DisciplinaryKnowledge Thinking Critical Solving Problem AnalyticalReasoning Skills Research Work Team ScientificReasoning Thinking Reflective Self Competence Multicultural Skills ICT Learning Long Life demonstrate the knowledge and skill gained CLO-1 : through learning of professional/elective courses 2 75 60 H H H H H H H H H H M H H H H taken on SWAYAM portal able to develop the professional skill on the CLO-2 : 2 80 70 H H H H H H H H H H M H H H H subject areas beyond his curriculum experience unique and independent learning CLO-3 : 2 70 65 H H H H H H H H M H M H H H H opportunity expand his/her knowledge of a particular area(s) CLO-4 : 2 70 70 H H H H H H H H H H M H H H H of interest to enhance employability

Learning Assessment Student shall be allowed to choose one Swayam course on the recommendation of faculty advisor and MOOCS appropriate credits will be transferred as per regulations 2021

73 M.Sc.Organic Chemistry

Course POC21I02L Course Internship Course P Project Work, L T P C Code Name Category Internship In 0 0 0 2 Industry / Higher Technical Institutions

Pre- Nil Co-requisite Nil Progressive Nil requisite Courses Courses Courses Course Offering Chemistry Data Book / Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR): CLR-1: gain experience 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 CLR-2: have a better understanding

CLR-3: have the opportunity to learn and watch.

CLR-4: gain the ability to put new things into practice.

CLR-5: Build confidence

CLR-6: get a feel for different working environment.

Course

2 3

Learning 1

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

(CLO):

Continuous Learning Assessment (50% weightage) Final Evaluation (50% weightage) Review – 1 Review – 2 Project Report Viva-Voce Internship 20% 30% 30% 20%

74 M.Sc.Organic Chemistry

Course Course Course L T P C PCD21AE3T Employability Skills A Ability Enhancement Course Code Name Category 1 0 0 1

Pre-requisite Co-requisite Progressive Nil Nil Nil Courses Courses Courses Course Offering Career Development Centre Nil Department

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR): CLR-1: develop contextual approach to acquire new vocabulary 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 CLR-2: establish clear relationship between words CLR-3: identify problems

CLR-4: learn the fundamental skills to solve problems

acquire experience of attending group discussion and

CLR-5:

personal interview

CLR-6: equipping students with necessary employability skills

Course

2 3

Learning 1

- -

At the end of this course, learners will be able to: -

Directed Learning Directed Skills Outcomes -

(CLO):

Duration 3 3 3 3 3 (hour) Permutation and Geometry and SLO-1 Time & work Probability S-1 Time, speed, distance combination Mensuration SLO-2 Solving problems Solving problems Solving problems Solving problems Solving problems

SLO-1 Perspective on Issues Critical Reasoning Synonyms Antonyms Word Analogy S-2 SLO-2 Perspective on Issues Critical Reasoning Synonyms Antonyms Word Analogy

SLO-1 Resume preparation Group Discussion Mock GD Interview Techniques Mock PI S-3 SLO-2 Resume preparation Group Discussion Mock GD Interview Techniques Mock PI 5. Quantitative aptitude by Dinesh Khattar 7. Verbal Advantage – Ten Easy Steps to a Powerful Learning 6. Ramachandran and Karthik, From Campus to Corporate, India, Vocabulary – Charles Harrington Elster Resources PEARSON Publication, 2016. 8. Barron’s GRE

# CLA – 4 can be from any combination of these: Assignments, Seminars, Scientific Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications etc.,

75 M.Sc.Organic Chemistry Course Designers Experts from Industry Internal Experts 1.Mr. Ajay Zenne, Career 1. Dr.P.Madhusoodhanan, SRMIST 2. Dr. A Clement, SRMIST Launcher,[email protected] 3. Dr.M.Snehalatha, SRMIST 4. Dr.Jayapragash J, SRMIST 2.Mr.Pratap Iyer, Study Abroad Mentors, 5. Mr. Harinarayana Rao, SRMIST 6. Mr. P Priyanand, SRMIST Mumbai,[email protected] 7. Mrs. Kavitha Srisarann, SRMIST

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76 M.Sc.Organic Chemistry

. Semester-IV

Course POC21P01L Course Project Work Course P Project Work, L T P C Code Name Category Internship In 0 0 24 12 Industry / Higher Technical Institutions

Pre- Nil Co- Nil Progressive Nil requisite requisite Courses Courses Courses Course Offering Chemistry Data Book / Nil Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR): Produce competent, creative and imaginative graduates CLR-1: 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 with a strong scientific acumen Apply of the acquired knowledge, skills, and tools pertinent CLR-2: to the field of Chemistry Promote independent and collaborative research work in CLR-3: the domain of chemistry Inculcate the ethical responsibility of the graduate in the CLR-4: scientific society Identify the challenges and solutions pertinent to the field of CLR-5:

Chemistry

Promote development of intellectual property by publishing

CLR-6: articles in high impact factor journals, conference

proceedings, patents

Course

2 3

Learning 1

- -

At the end of this course, learners will be able to: - Directed Learning Directed

Outcomes -

(CLO):

Continuous Learning Assessment (50% weightage) Final Evaluation (50% weightage) Review – 1* Review – 2* Project Report* Viva-Voce Project Work 20% 30% 30% 20%

* includes submission of project work in the form of paper for presentation/publication in a conference/journal and/or preliminary filing of a patent with proof.

77 M.Sc.Organic Chemistry GENERIC ELECTIVES OFFERED BY THE CHEMISTRY DEPARTMENT

Course Course Course L T P C PCY21G02T Chemistry of Biomolecules G Generic elective course Code Name Category 3 0 0 3

Pre- Co- Progressive requisite Nil requisite Nil Nil Courses Courses Courses Course Offering Data Book / Chemistry NIL Department Codes/Standards

Course Learning The purpose of learning this course is to: Learning Program Learning Outcomes (PLO) Rationale (CLR):

To develop a sound knowledge of the CLR-1 : 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 fundamental concepts in bio-organic chemistry Provide basic understanding about the biomolecules like amino CLR-2 : acids, proteins, nucleic acids, lipids and carbohydrates appreciate the role of these biomolecules in CLR-3 : biology. gain knowledge about enzymes and CLR-4 : coenzymes apply the information gained about enzymes

CLR-5 : and coenzymes into organic chemistry

applications like molecule synthesis

gain knowledge about amino acids and

CLR:6

proteins and their structural features

Course

Thinking

1 2

Learning At the end of this course, learners will be able

- - –

Learning Directed Outcomes to: -

(CLO):

DisciplinaryKnowledge Critical Solving Problem AnalyticalReasoning Skills Research Work Team ScientificReasoning Thinking Reflective Self Competence Multicultural Skills ICT Learning Long Life Level of Thinking (Bloom) of Thinking Level (%) Proficiency Expected Attainment (%) Expected PSO PSO PSO inculcate the organic chemistry knowledge to CLO-1 : 2 75 60 H H H L H H H H H L H H H H H gain insight into biomolecule systems apply the information gained about enzymes CLO-2 : 2 80 70 H H L H H H H L L H H L H H H and coenzymes into organic synthesis. understand the importance of nucleic acid in CLO-3 : 2 70 65 H H M M H L H L L H H L H H H bioorganic chemistry understand the importance of carbohydrate CLO-4 2 70 70 H L H H H L M L L H H L H H H chemistry understand the significant role of amino acid, CLO-5 2 80 70 H H H M M H H L L H H L H H H peptides and proteins in bioorganic chemistry understand interactions between amino acids, CLO-6 peptides, nucleic acids and there role in 2 75 70 H H H H H H H H H H H H H H H biomolecule structure

Duration (hour) (9) (9) (9) (9) (9) Classification and Nature of genetic material Fatty acids classification Classification of SLO-1 Enzymes, Classification structure of amino acids carbohydrates S-1 Classification and Nature of genetic material Fatty acids classification Classification of SLO-2 Enzymes, Classification structure of amino acids carbohydrates Configuration of amino Structure of purine and Nomenclature, structure of acids, acid-base pyrimidine fatty acids Stereo isomerism of SLO-1 Kinetics, inhibition properties sugars and isoelectric point S-2 Configuration of amino Structure of purine and Nomenclature, structure of acids, acid-base pyrimidine fatty acids Stereo isomerism of SLO-2 Kinetics, inhibition properties sugars and isoelectric point Separation of amino Mechanisms of enzyme Nucleotides and Properties of fatty acids Optical isomerism of SLO-1 acids action nucleosides sugars S-3 Separation of amino Mechanisms of enzyme Nucleotides and Properties of fatty acids Optical isomerism of SLO-2 acids action nucleosides sugars Peptide bonds, disulfide Types Structure and function of Cofactors as derived Mutarotation, S-4 SLO-1 linkages of nucleic acids prostaglandins, tri-acyl from vitamins, co-enzymes occurrence, glycerol

78 M.Sc.Organic Chemistry Peptide bonds, disulfide Types Structure and function of Cofactors as derived Mutarotation, SLO-2 linkages of nucleic acids prostaglandins, tri-acyl from vitamins, co-enzymes occurrence, glycerol Proteins Prosthetic, prosthetic group Structure of DNA Structure and functions of classification based on and apoenzymes phospholipids, Structure of mono and di SLO-1 solubility, shape, saccharides composition and function, S-5 Proteins Prosthetic, prosthetic group Structure of DNA Structure and functions of classification based on and apoenzymes phospholipids, Structure of mono and di SLO-2 solubility, shape, saccharides composition and function, Structure of Structure and Properties of nucleic acids Spingomyelin Biological importance of SLO-1 polysaccharides biological functions of mono, di and coenzyme-A polysaccharides S-6 Structure of proteins Structure and Tm, denaturation and Spingomyelin Biological importance of SLO-2 biological functions of renaturation mono, di and coenzyme-A polysaccharides Structure of proteins Thiamine pyrophosphate, Hypo and hyperchromicity Plasmologens An introduction SLO-1 pyridoxal phosphate to mucopolysaccharides Determination of the Thiamine pyrophosphate, Basic ideas on replication Plasmologens S-7 primary structure of a pyridoxal phosphate An introduction SLO-2 protein, secondary, to mucopolysaccharides tertiary and quaternary structures, Determination of the NAD+, Transcription and Structure and function of Reactions of primary structure of a NADP+ translation glycolipids, carbohydrates due to the SLO-1 protein, secondary, presence of hydroxyl, tertiary and quaternary aldehyde structures, and ketone groups. S-8 Determination of the FAD, lipoic acid Transcription and Structure and function of Reactions of primary structure of a translation glycolipids, carbohydrates due to the SLO-2 protein, secondary, presence of hydroxyl, tertiary and quaternary aldehyde structures, and ketone groups. Protein denaturation. Overview of reactions Determination Cholesterol. Reactions of catalysed by the above of the base sequence of carbohydrates due to the SLO-1 cofactors DNA presence of hydroxyl, aldehyde S-9 and ketone groups.

Protein denaturation. Overview of reactions Determination Cholesterol. Reactions of

catalysed by the above of the base sequence of carbohydrates due to the SLO-2 cofactors DNA presence of hydroxyl, aldehyde and ketone groups.

1.D. L. Nelson, M. M. Cox, Lehninger Principles of Biochemistry, 5thEd., W. H. Freeman; New York, USA, 2005. Learning 2. R. K. Murray, D. K. Grammer, Harper’s Biochemistry, 29th Ed., McGraw Hill, Lange Medical Books, United Kingdom, 2009. Resources 3. J.L. Jain, S. Jain, N. Jain, Fundamentals of Biochemistry, S. Chand & Company. India, 2013. 4. P. Y. Bruice, Organic Chemistry, 5th Ed., Pearson, 2014.

Learning Assessment Continuous Learning Assessment (50% weightage) Bloom’s Final Examination (50% weightage) Level of CLA – 1 (10%) CLA – 2 (10%) CLA – 3 (20%) CLA – 4 (10%)# Thinking Theory Practice Theory Practice Theory Practice Theory Practice Theory Practice Remember Level 1 40% - 30% - 30% - 30% - 30% - Understand Apply Level 2 40% - 40% - 40% - 40% - 40% - Analyze Evaluate Level 3 20% - 30% - 30% - 30% - 30% - Create Total 100 % 100 % 100 % 100 % 100 %

# CLA – 4 can be from any combination of these: Assignments, Seminars, Tech Talks, Mini-Projects, Case-Studies, Self-Study, MOOCs, Certifications, Conf. Paper etc.,

79 M.Sc.Organic Chemistry Course Designers Experts from Industry Expert from Higher Technical Institutions Internal Experts 1. Prof. G. Sekar, Professor, Department of Chemistry, IIT Madras 1. Dr. M. Arthanareeswari , SRMIST Dr. Ravikiran Allada, Head R&D, Email: [email protected] Analytical, Novugen Pharma, Malaysia 2. Dr. Kanishka Biswas, Associate Professor, Email: [email protected] New Chemistry Unit, Jawaharlal Nehru Centre 2. Dr. Priyadip Das, SRMIST for Advanced Scientific Research (JNCASR), Bengaluru. Email: [email protected]

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80 M.Sc.Organic Chemistry