DOCSLIB.ORG

Biomarkers and Risk Stratification in Colorectal Neoplasia

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Biomarkers and Risk Stratification in Colorectal Neoplasia Biomarkers and Risk Stratification in Colorectal Neoplasia A thesis submitted to the University of Manchester for the degree of Doctor of Medicine in the Faculty of Biology, Medicine and Health. 2019 Lyndsay E Pearce BMedSci BMBS FRCS School of Medical Sciences Table of Contents 1 Introduction ................................................................ 18 1.1 Pre symptomatic diagnosis and screening for Colorectal Cancer ............................................................................. 21 1.1.1 Background to Colorectal Cancer Screening ............................... 21 1.1.2 The UK National Bowel Cancer Screening Programme .................. 23 1.1.3 Faecal Occult Blood Testing ..................................................... 23 1.1.4 Faecal immunohistochemical testing ......................................... 24 1.1.5 Flexible sigmoidoscopy ........................................................... 25 1.1.6 Individualising risk and colorectal cancer screening .................... 26 1.1.7 Moderate Familial Risk ........................................................... 26 1.1.8 Screening in familial colorectal cancer syndromes ...................... 27 1.2 Single Gene disorders .................................................... 29 1.2.1 Familial Adenomatous Polyposis .............................................. 29 1.2.1.1 Introduction and History ................................................... 29 1.2.1.2 Variation in phenotypic features ......................................... 30 1.2.1.3 Desmoid Tumours ............................................................ 31 1.2.1.4 Polyp surveillance in FAP and AFAP .................................... 32 1.2.2 Lynch Syndrome ................................................................... 33 1.2.1.1 Introduction and History ................................................... 33 1.2.1.2 Diagnosis of Lynch Syndrome ............................................ 34 1.2.1.3 Amsterdam/Bethesda Criteria ............................................ 37 1.2.1.4 Other predictive models .................................................... 40 1.2.1.5 Genetic modifiers ............................................................. 41 1.2.1.6 Surveillance and screening in Lynch Syndrome .................... 42 1.2.3 Polyposis Phenotype .............................................................. 45 1.2.3.1 Hyperplastic Polyposis ...................................................... 45 1.2.3.2 Multiple Adenoma Phenotype ............................................. 46 1.2.3.2.1 Oligopolyposis .......................................................... 46 1.2.3.2.2 MUTYH associate polyposis ........................................ 47 1.2.3.2.3 NTHL1-associated polyposis ....................................... 48 1.2.3.3 Peutz Jeghers Syndrome ................................................... 48 1.2.3.4 Juvenile Polyposis Syndrome ............................................. 48 1.2.3.5 Cowden’s Syndrome ......................................................... 49 1.3 Diagnosis and Staging of Colorectal Cancer .................. 50 1.3.1 Imaging and diagnosis of CRC ................................................. 50 1.3.2. Pathology of Colorectal Cancer ................................................. 53 1.3.2.1 Adenocarcinoma .............................................................. 53 1.3.2.2 Precursor lesions (polyps) ................................................. 53 1.3.2.2.1 Adenomas ............................................................... 53 1.3.2.2.2 Serrated Adenomas .................................................. 54 1.3.2.2.3 Hamartomas ............................................................ 55 1.3.2.2.4 Inflammatory Polyps ................................................. 56 1.3.3 Staging of colorectal cancer .................................................... 56 1.3.3.1 Radiological staging ......................................................... 57 1.3.3.1.1. PET CT .................................................................... 58 1.4 Treatment of Colorectal Cancer ...................................... 58 1.4.1. Early colorectal cancer ............................................................ 58 1.4.2 Stage II , III and IV Colorectal cancer ...................................... 58 1.4.3 Treatment considerations in Lynch Syndrome ............................ 59 1.4.3.1 Prophylactic Surgery ........................................................ 60 1.4.3.2 Adjuvant Therapy ............................................................ 61 1.4.3.2.1 Fluorouracil-based adjuvant chemotherapy .................. 62 2 1.5 Follow-up after resection for Colorectal Cancer ............. 64 1.5.1 Carcinoembryonic Antigen ............................................... 64 1.5.2 CT scanning ................................................................... 65 1.5.3 Positron Emission Tomography (PET CT) ............................ 65 1.5.4 Surveillance programmes ................................................ 66 1.5.5 Colorectal liver metastases .............................................. 68 1.6 Colorectal Cancer Molecular Genetics ............................ 69 1.6.1 Fearon and Vogelstein’s genetic model for tumourigenesis .... 70 1.6.2 Jass’ molecular classification of colorectal cancer ................. 70 1.6.3 Genetic Instability ............................................................ 71 1.6.3.1 Epigenetics ..................................................................... 71 1.6.3.2 Jass’ Classification ........................................................... 72 1.6.3.2.1 The Microsatellite Instability Pathway .......................... 73 1.6.3.2.2 The Chromosomal Instability Pathway ......................... 73 1.7 Principles of Biomarkers ............................................... 74 1.7.1 Categorisation of Biomarkers .................................................. 75 1.7.2 Biomarker Discovery .............................................................. 76 1.7.3 Biomarker Validation ............................................................. 77 1.7.4 Biomarker discovery roadmaps ............................................... 77 1.7.5 Biomarkers in Colorectal Cancer .............................................. 77 1.7.5.1 Risk stratification (predisposition) biomarkers ...................... 78 1.7.5.2 Screening and early detection biomarkers ........................... 78 1.7.5.3 Diagnostic Biomarkers ...................................................... 79 1.7.5.4 Pharmacological Biomarkers .............................................. 79 1.7.5.5 Predictive Biomarkers ....................................................... 79 1.7.5.5.1 KRAS ..................................................................... 80 1.7.5.6 Population based screening biomarkers .............................. 81 1.7.5.7 Predictive value of MSI in chemotherapy ............................. 81 1.7.5.8 Circulating Tumour Cells ................................................... 82 1.7.5.9 Tumour biology ............................................................... 83 1.7.5.9.1 Beta-2 microglobulin as a biomarker in MMR-deficient CRC 84 1.7.5.9.2 Immune response to tumour cells ............................... 85 1.7.5.9.3 Natural Killer Cells .................................................... 87 1.8 Common genetic variants and Colorectal Cancer ............ 88 1.8.1 Genome Wide Association Studies ........................................... 88 1.8.2 Single Nucleotide Polymorphisms ............................................ 89 1.8.3 Polygenic risk ....................................................................... 89 1.8.4 Genetic Linkage analysis ........................................................ 90 1.8.4.1 Common Disease/Common Variant Hypothesis .................... 90 1.8.4.2 Linkage disequilibrium ...................................................... 91 1.8.4.3 Direct and Indirect Association .......................................... 91 1.8.5 GWAS and colorectal cancer ................................................... 92 1.8.5.1 History and Discovery of SNPs in colorectal cancer ............... 94 1.8.6 Functions of CRC association single nucleotide polymorphisms ..... 95 1.8.6.1 BMP ............................................................................... 95 1.8.6.2 TERC ............................................................................. 96 1.8.7 Population specific risk ........................................................... 96 1.8.7.1 CRC risk and SNPs in high risk populations .......................... 97 1.8.7.2 Lynch syndrome and susceptibility loci ............................... 98 1.8.8 SNPs and adenoma ................................................................ 99 1.8.8.1 Polyposis Phenotype ........................................................ 100 1.8.8.1.1 FAP ....................................................................... 100 1.8.8.1.2 Oligopolyposis ......................................................... 101 1.8.9 Patterns of disease and types of disease .................................. 102 3 1.8.9.1 Protective effects ............................................................ 103 1.8.9.2 Long term survival and early onset colorectal cancer ........... 104 STUDY ONE ..................................................................... 105 The effect of intensive CT scanning in surveillance to detect the recurrence of colorectal
Load more

Recommended publications
  • Some Psychoanalytical Meanings of the Skin in the Book of Job
    Verbum et Ecclesia ISSN: (Online) 2074-7705, (Print) 1609-9982 Page 1 of 8 Original Research Some psychoanalytical meanings of the skin in the book of Job Author: Traditionally, there has been a tension between psychology and religion because of the 1 Pieter van der Zwan Freudian critique of religion. This research intends to show that a deeper understanding of Affiliation: religion leading hopefully to an even deeper religiosity can be achieved by studying bodily 1Department of Old features portrayed in a (religious) text from a psychoanalytic perspective. Just as any literary Testament Studies, University character can be ‘psychoanalysed’ to produce new perspectives on it and on the narrative as a of Pretoria, South Africa whole, the personality of Job invites the postmodern reader to continue understanding this Corresponding author: book on new levels. From this approach, it becomes clear that the protagonist struggles with Pieter van der Zwan, boundaries and individuation because of his depressive tendencies experienced in issues with [email protected] reality’s harsh touch, nakedness and distance. Dates: Intradisciplinary and/or interdisciplinary implications: Just as any literary character can be Received: 09 May 2016 ‘psychoanalysed’ to produce new perspectives on it and on the narrative as a whole, the Accepted: 01 Aug. 2017 Published: 21 Sept. 2017 personality of Job invites the postmodern reader to continue understanding this book on new levels. From this approach, it becomes clear that the protagonist struggles with boundaries How to cite this article: and individuation because of his depressive tendencies experienced in issues with reality’s Van der Zwan, P., 2017, ‘Some harsh touch, nakedness and distance.
    [Show full text]
  • This Electronic Thesis Or Dissertation Has Been Downloaded from the King’S Research Portal At
    This electronic thesis or dissertation has been downloaded from the King’s Research Portal at https://kclpure.kcl.ac.uk/portal/ Inimitable? The Afterlives and Cultural Memory of Charles Dickens’s Characters England, Maureen Bridget Awarding institution: King's College London The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without proper acknowledgement. END USER LICENCE AGREEMENT Unless another licence is stated on the immediately following page this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence. https://creativecommons.org/licenses/by-nc-nd/4.0/ You are free to copy, distribute and transmit the work Under the following conditions: Attribution: You must attribute the work in the manner specified by the author (but not in any way that suggests that they endorse you or your use of the work). Non Commercial: You may not use this work for commercial purposes. No Derivative Works - You may not alter, transform, or build upon this work. Any of these conditions can be waived if you receive permission from the author. Your fair dealings and other rights are in no way affected by the above. Take down policy If you believe that this document breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. Download date: 08. Oct. 2021 1 INIMITABLE? THE AFTERLIVES AND CULTURAL MEMORY OF CHARLES DICKENS’S CHARACTERS Maureen Bridget England King’s College London Candidate Number: 1233164 Thesis for PhD in English Literature 2 This paper is dedicated to the two doctors in my life who inspired me to pursue this dream: Martin England and Jenna Higgins 3 ‘Any successfully evoked character, no matter how apparently insignificant, stands a good chance of surviving its creator.’ David Galef, The Supporting Cast (1993) 4 Table of Contents TABLE OF CONTENTS ........................................................................................................
    [Show full text]
  • Etherology, Or, the Philosophy of Mesmerism
    TUFTS COLLEGE Tufts College Library « PHRENOLOG1.0AL BUST. See Page 164. • E THEE 0 LOG Y; OR, THE PHILOSOPHY OF MESMERISM . AND PHRENOLOGY: INCLUDING A NEW PHILOSOPHY OF SLEEP AND OF CONSCIOUSNESS, WITH A REVIEW OF THE PRETENSIONS OF NEUROLOGY AND PHRENO-MAGNETISM BY J. STANLEY GRIMES, COUNSELLOR AT LAW, FORMERLY PRESIDENT OF THE WESTERN PHRENOLOGICAL SOCIETY, PROFESSOR OF MEDICAL JURISPRUDENCE IN THE CASTLETON MEDICAL COLLEGE AND AUTHOR OF 4 A NEW SYSTEM OF PHRENOLOGY.' All the known phenomena of the universe may he referred to three general princi- ples, viz.: Matter, Motion, and Consciousness.—p. 17. NEW YORK: SAXTON AND MILES, NO. 205 BROADWAY PHILADELPHIA :-J AMES M. CAMPBELL. BOSTON I SAXTON, PEIRCE & CO. 1845. year by Entered according to Act of Congress, in the 1845, J. STANLEY GRIMES, the Southern District In the Clerk's Office of the District Court of of New York. 1 i m CONTENTS. SECTION I. page. SYNOFSIS OF ETHEROLOGY . 17 SECTION II. HISTORY OF ETHERIUM ..... 39 Ignorance of the Ancients concerning the causes of Ethe- rean Phenomena — Witchcraft — Divination — Magic — Discoveries which led to a Scientific Knowledge of Ethe- ropathy—Van Helmot—Mesmer—His Career—D'Eslon —Adverse Report of the French Commissioners—Foissac and the Academy of Medicine—Their favorable report —Gall—La Place. SECTION III. NATURE OF ETHERIUM ..... 75 Theory of Light—Of Heat—Of Electricity—Of Magnetism— Of Gravitation—Newton's Conjecture—Rev. Mr. Town- shend on the Mesmeric Medium—Sunderland's Notions —Animal Electricity—Experiments of Crosse—Electric Fishes. SECTION IV. OXYGEN ........ 127 SECTION V. PHILOSOPHY OF SLEEP 130 Liebig's Error.
    [Show full text]
  • The Impact of Vision Theories on Late Nineteenth-Century Victorian Literature
    University of Central Florida STARS Electronic Theses and Dissertations, 2004-2019 2019 Concerning the Perceptive Gaze: The Impact of Vision Theories on Late Nineteenth-Century Victorian Literature Lindsay Rushworth University of Central Florida Part of the English Language and Literature Commons Find similar works at: https://stars.library.ucf.edu/etd University of Central Florida Libraries http://library.ucf.edu This Masters Thesis (Open Access) is brought to you for free and open access by STARS. It has been accepted for inclusion in Electronic Theses and Dissertations, 2004-2019 by an authorized administrator of STARS. For more information, please contact [email protected]. STARS Citation Rushworth, Lindsay, "Concerning the Perceptive Gaze: The Impact of Vision Theories on Late Nineteenth- Century Victorian Literature" (2019). Electronic Theses and Dissertations, 2004-2019. 6420. https://stars.library.ucf.edu/etd/6420 CONCERNING THE PERCEPTIVE GAZE: THE IMPACT OF VISION THEORIES ON LATE NINTEENTH-CENTURY VICTORIAN LITERATURE by LINDSAY RUSHWORTH B.A. University of Florida, 2012 A thesis submitted in partial fulfillment of the requirements for the degree of Master of Arts in the Department of English in the College of Arts and Humanities at the University of Central Florida Orlando, Florida Spring Term 2019 ABSTRACT This thesis examines two specific interventions in vision theory—namely, Herbert Spencer’s theory of organic memory, which he developed by way of Lamarckian genetics and Darwinian evolution in A System of Synthetic Philosophy (1864), and the Aesthetic Movement (1870s–1890s), famously articulated by Walter Pater in The Renaissance: Studies in Art and Poetry (1873 and 1893). I explore the impact of these theories on late nineteenth-century fiction, focusing on two novels: Thomas Hardy’s Two on a Tower (1882) and Edith Johnstone’s A Sunless Heart (1894).
    [Show full text]
  • The Resurrection of Jesus: a Clinical Review of Psychiatric Hypotheses for the Biblical Story of Easter
    Scholars Crossing LBTS Faculty Publications and Presentations 2015 The Resurrection of Jesus: A Clinical Review of Psychiatric Hypotheses for the Biblical Story of Easter Joseph Bergeron Gary R. Habermas Liberty University, [email protected] Follow this and additional works at: https://digitalcommons.liberty.edu/lts_fac_pubs Part of the Christianity Commons, and the Religious Thought, Theology and Philosophy of Religion Commons Recommended Citation Bergeron, Joseph and Habermas, Gary R., "The Resurrection of Jesus: A Clinical Review of Psychiatric Hypotheses for the Biblical Story of Easter" (2015). LBTS Faculty Publications and Presentations. 402. https://digitalcommons.liberty.edu/lts_fac_pubs/402 This Article is brought to you for free and open access by Scholars Crossing. It has been accepted for inclusion in LBTS Faculty Publications and Presentations by an authorized administrator of Scholars Crossing. For more information, please contact [email protected]. The Resurrection of Jesus: a Clinical Review of Psychiatric Hypotheses for the Biblical Story of Easter Joseph W. Bergeron, M.D. and Gary R. Habermas, Ph.D.1 ABSTRACT Jesus’ resurrection to bodily life after death by crucifixion is foundational to orthodox Christianity. The disciples had encounters with Jesus after his crucifixion which caused them to believe he had been bodily resurrected to life again. Psychiatric hypotheses have been proposed as naturalistic explanations for his disciples’ beliefs, which include hallucinations, conversion disorder, and bereavement experiences. Since they propose hallucinatory symptoms that suggest the presence of underlying medical pathology, clinical appraisal of these hypotheses for the disciples’ encounters with the resurrected Jesus is warranted. Psychiatric hypotheses for the disciples’ belief in Jesus’ resurrection are found to be inconsistent with current medical understanding and do not offer plausible explanations for the biblical story of Easter.
    [Show full text]
  • Monomania: the Life and Death of a Psychiatric Idea in Nineteenth-Century Fiction 1836-1860
    Open Research Online The Open University’s repository of research publications and other research outputs Monomania: The Life and Death of a Psychiatric Idea in Nineteenth-Century Fiction 1836-1860 Thesis How to cite: Stewart, Lindsey (2018). Monomania: The Life and Death of a Psychiatric Idea in Nineteenth-Century Fiction 1836-1860. PhD thesis The Open University. For guidance on citations see FAQs. c 2017 The Author https://creativecommons.org/licenses/by-nc-nd/4.0/ Version: Version of Record Link(s) to article on publisher’s website: http://dx.doi.org/doi:10.21954/ou.ro.0000d93a Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online’s data policy on reuse of materials please consult the policies page. oro.open.ac.uk MONOMANIA: THE LIFE AND DEATH OF A PSYCHIATRIC IDEA IN NINETEENTH- CENTURY FICTION 1836-1860 A thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy by Lindsey Stewart Department of English, The Open University October 2017 i Abstract This thesis is about the nineteenth-century psychiatric idea, monomania, in medical, literary and popular discourse from 1836-1860. I examine patient case-notes from the Bethlem, York Retreat and Surrey County Pauper Asylum to establish that the experiential or ‘real’ narratives of monomaniacs confirm the category’s initial confusion with melancholia, and then its conflation with social commentary. Used sparingly in clinical practice, physicians account for a range of anti-social behaviour with its deployment as a diagnosis.
    [Show full text]
  • Title: the Image of the Body-Face: the Case of Franz Xaver Messerschmidt and Bill Viola Author: Maria Popczyk Citation Style: Po
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE Title: The image of the body-face: The case of Franz Xaver Messerschmidt and Bill Viola Author: Maria Popczyk Citation style: Popczyk Maria. The image of the body-face: The case of Franz Xaver Messerschmidt and Bill Viola. "Argument" (2015, nr 1, s. 99-110). ArgUmEnt Vol. 5 (1/2015) pp. 99–110 e­­‑ISSn 2084–1043 ISS n 2083–6635 The image of the body‑face:­­ The case of Franz Xaver Messerschmidt and Bill Viola * maria POPCZYK ABStrACt In this paper, I am predominantly interested in interpretations of emotional states portrayed in images of the face. In particular, the interpretations which have grown around the series of busts by Franz Xaver messerschmidt, as well as those which attempt to expound Bill Viola’s video works. I will refer to aspects of physiognomy, artistic practices and aesthetics, in order to show what each of these tells us about our attitude to the body and emotions and what hap‑ pens to the body while a person is experiencing an emotion. my aim is to demonstrate how the act of depicting the body, regarded as a cognitive process in an artistic medium accompanied by a special kind of aesthetic experience, becomes a means of communication which is capable of conveying a universal message and of allowing us to define our attitude to the body. KEYWOrDS body; physionomy; aesthetics; art; emotion; Franz Xaver messerschmidt; Bill Viola; contem‑ porary art; bodily expression * Associate Professor, Department of Cultural Studies, University of Silesia, Katowice, Poland.
    [Show full text]
  • Writing Emotions
    Ingeborg Jandl, Susanne Knaller, Sabine Schönfellner, Gudrun Tockner (eds.) Writing Emotions Lettre 2017-05-15 15-01-57 --- Projekt: transcript.titeleien / Dokument: FAX ID 0247461218271772|(S. 1- 4) TIT3793_KU.p 461218271780 2017-05-15 15-01-57 --- Projekt: transcript.titeleien / Dokument: FAX ID 0247461218271772|(S. 1- 4) TIT3793_KU.p 461218271780 Ingeborg Jandl, Susanne Knaller, Sabine Schönfellner, Gudrun Tockner (eds.) Writing Emotions Theoretical Concepts and Selected Case Studies in Literature 2017-05-15 15-01-57 --- Projekt: transcript.titeleien / Dokument: FAX ID 0247461218271772|(S. 1- 4) TIT3793_KU.p 461218271780 Printed with the support of the State of Styria (Department for Health, Care and Science/Department Science and Research), the University of Graz, and the Faculty of Arts and Humanities University of Graz. An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high quality books Open Access for the public good. The Open Access ISBN for this book is 978-3-8394-3793-3. More information about the initiative and links to the Open Access version can be found at www.knowledgeunlatched.org. This work is licensed under the Creative Commons Attribution-NonCommercial-No- Derivs 4.0 (BY-NC-ND) which means that the text may be used for non-commercial purposes, provided credit is given to the author. For details go to http://creativecommons.org/licenses/by-nc-nd/4.0/. To create an adaptation, translation, or derivative
    [Show full text]
  • Darwin's Emotions
    The Face of Physiology Paul White Man is gregarious, he looks for sympathy [...] and the language which expresses it is in the face.1 In Jane Eyre (1847), there is a rare comic interlude when Rochester, disguised as a gypsy woman, reads the fortunes of his party guests in their faces. In Jane he finds „the eye [...] favourable [...] the mouth [...] propitious [he sees] no enemy to a fortunate issue but in the brow; and that brow professes to say, – “I can live alone”‟.2 The great importance of facial features and expressions for judgements of character in the nineteenth century has been well-documented. The work of Mary Cowling and others has shown the enduring power of physiognomy and related traditions, phrenology and pathognomy, for the representation and reading of character in literature and the visual arts.3 Popular treatises and handbooks on the subject appear through the end of the century.4 Many assumptions about the relationship between external attributes and intellectual and moral capacity persist within the new human sciences, anthropology, ethnology and criminology, with their emphasis on racial, aberrant or degenerate social types. Indeed, such typologies not only endure, but proliferate in the last quarter of the century, underpinned by more precise methods of recording and measuring. Craniometries, nasologies and so forth, gained new legitimacy and purchase through the application of precision instruments. Racial types were marked by facial angles and cranial distances that differed by no more than a millimetre.5 Photography was enlisted to map and classify facial features across the empire and at home.6 Alongside these developments in the study of external features and form, there was another movement that sought the traces of character beneath the surface.
    [Show full text]
  • POWER of the PORTRAIT: Production, Consumption and Display of Portraits of Amalia Van Solms in the Dutch Republic
    POWER OF THE PORTRAIT: Production, Consumption and Display of Portraits of Amalia van Solms In the Dutch Republic by Saskia Beranek B.A., Pennsylvania State University, 2001 M.A., Duke University, 2003 Submitted to the Graduate Faculty of The Kenneth P. Dietrich School of Arts and Sciences in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Pittsburgh 2013 UNIVERSITY OF PITTSBURGH Kenneth P. Dietrich School of Arts and Sciences This dissertation was presented by Saskia Beranek It was defended on March 29, 2013 and approved by Jennifer Waldron, Associate Professor, English Joshua Ellenbogen, Associate Professor, History of Art and Architecture Stephanie Dickey, Bader Chair in Northern Baroque Art, Queen's University, Art Co-Advisor: C. Drew Armstrong, Associate Professor and Director of Architectural Studies Dissertation Advisor: Ann Sutherland Harris, Professor Emerita, History of Art and Architecture ii Copyright © by Saskia Beranek 2013 iii POWER OF THE PORTRAIT: Production, Consumption and Display of Portraits of Amalia van Solms in the Dutch Republic Saskia Beranek, PhD University of Pittsburgh, 2013 Portraits of Amalia van Solms, wife of Frederik Hendrik of Orange-Nassau and one of the most significant women in the Dutch Republic, were widely circulated and displayed during her lifetime (1602-1675). This study focuses on cases where specific audiences and sites of display can be isolated. When portraits can be viewed in their original context, they speak not only to those elements intrinsic to the image such as symbolism or fashion, but also to issues extrinsic to the image: social practices, cultural ideals, and individual identities.
    [Show full text]
  • Speaking Faces and Bodies
    DIPLOMARBEIT Titel der Diplomarbeit „Speaking Bodies and Faces: Functions of Physiognomic Descriptions in Jane Eyre and Villette by Charlotte Brontë“ Verfasserin Anna Wöckinger angestrebter akademischer Grad Magistra der Philosophie (Mag. phil.) Wien, 2012 Studienkennzahl lt. Studienblatt: A 343 Studienrichtung lt. Studienblatt: Diplomstudium Anglistik und Amerikanistik Betreuerin Ao. Univ.-Prof. Dr. Mag. Eva Müller-Zettelmann 1 Introduction ....................................................................................... 1 2 Lavater’s Physiognomy ..................................................................... 3 2.1 Definition and relevance ............................................................................... 3 2.2 Influences and origins .................................................................................. 8 2.2.1 Aristotle (384 BC – 322 BC) .................................................................. 9 2.2.2 Giambattista della Porta (1535-1615) ................................................. 10 2.2.3 Franz Joseph Gall (1758-1828) ........................................................... 11 2.2.4 Physiognomy and Pathognomy ........................................................... 11 2.3 Three basic principles ................................................................................ 13 2.4 Beauty in Lavater’s Physiognomy = Beauty in Bront? .............................. 14 3 Physiognomic descriptions in the novel ........................................... 18 3.1 “The recognition of
    [Show full text]
  • On Physiognomy
    Georg Christoph Lichtenberg, On Physiognomy; Against the Physiognomists: For the Promotion of Human Knowledge and the Love of Humanity (1778) Abstract Georg Christoph Lichtenberg (1742–99) was an experimental physicist and aphorist in Göttingen. He was known for both his electrical experiments and his posthumously published Aphorisms. In his reply to Johann Caspar Lavater, he decries the spread of physiognomy as a fashionable superstitious practice in which we “read the stars” in people's foreheads. Lichtenberg distinguishes between physiognomy (as a reductive attempt to link character and behavior to physical features) and pathognomy, the study of affect, emotion, and expression. The latter, he maintains, has some validity, as it preserves a role for human will and understanding. Source On Physiognomy Certainly, the liberty of our thoughts and the most private excitations of our hearts have never stood on a weaker footing than now, when the industry, the number, and the courage of the heroes who revolt against them make their imminent collapse foreseeable. From all sides, these invaders storm the most vulnerable fortifications, and everywhere else secret stockpiles are suspected, with a zeal that more resembles a Gothic or Vandal onslaught than a premeditated siege; and many maintain that formal surrender simply cannot be long in coming. But there is also a good number of less sanguine people who think that the soul still lies over its most secret treasure, as inviolably safe as millennia ago, and who smile at the increasingly Babylonian constructions of their haughty besiegers, convinced that, long before these works’ completion, the workers’ languages will grow confused, and master and apprentice will part ways.
    [Show full text]