Scientific Committee on Toxicity, Ecotoxicity and the Environment
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Recipe 2016 V1.1 a Harmonized Life Cycle Impact Assessment Method at Midpoint and Endpoint Level Report I: Characterization
ReCiPe 2016 v1.1 A harmonized life cycle impact assessment method at midpoint and endpoint level Report I: Characterization RIVM Report 2016-0104a RIVM Report 2016-0104 Colophon © RIVM 2017 Parts of this publication may be reproduced, provided acknowledgement is given to: National Institute for Public Health and the Environment, along with the title and year of publication. M.A.J. Huijbregts (author), Radboud University Nijmegen Z.J.N. Steinmann (author), Radboud University Nijmegen P.M.F. Elshout (author), Radboud University Nijmegen G. Stam (author), Radboud University Nijmegen F. Verones (author), NTNU Trondheim M.D.M. Vieira (author), Radboud University Nijmegen, Pré Consultants A. Hollander (author), RIVM M. Zijp (author), RIVM R. van Zelm (author), Radboud University Nijmegen Contact: Anne Hollander RIVM/DMG [email protected] This investigation has been performed by order and for the account of Ministerie IenM, within the framework of Van Afval naar Grondstof This is a publication of: National Institute for Public Health and the Environment P.O. Box 1 | 3720 BA Bilthoven The Netherlands www.rivm.nl/en Page 2 of 201 RIVM Report 2016-0104 Synopsis ReCiPe 2016 v1.1 A harmonized life cycle impact assessment method at midpoint and endpoint level Report I: Characterization Life cycle assessment (LCA) enables the assessment of the pressure a certain (production) process places on the environment. The assessment comprises all phases needed to produce and use a product, from the initial development to the treatment of waste (the total life cycle). The goal of LCA is, for example, to compare alternatives or to identify phases in the production process that place a relatively high level of pressure on the environment. -
AN INTRODUCTION to AQUATIC TOXICOLOGY This Page Intentionally Left Blank ÂÂ an INTRODUCTION to AQUATIC TOXICOLOGY
AN INTRODUCTION TO AQUATIC TOXICOLOGY This page intentionally left blank AN INTRODUCTION TO AQUATIC TOXICOLOGY MIKKO NIKINMAA Professor of Zoology, Department of Biology, Laboratory of Animal Physiology, University of Turku, Turku, Finland AMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD • PARIS • SAN DIEGO SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO Academic press is an imprint of Elsevier Academic Press is an imprint of Elsevier The Boulevard, Langford Lane, Kidlington, Oxford, OX5 1GB, UK 225 Wyman Street, Waltham, MA 02451, USA Copyright © 2014 Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangement with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. -
Genetic and Molecular Ecotoxicology: a Research Framework
Genetic and Molecular Ecotoxicology: A Research Framework Susan Anderson,1 Walter Sadinski,1 Lee Shugart,2 Peter Brussard,3 Michael Depledge,4 Tim Ford,5 JoEllen Hose,6 John Stegeman,7 William Suk,8 Isaac Wirgin,9 and Gerald Wogan0 1Lawrence Berkeley Laboratory, Berkeley, California; 2Oak Ridge National Laboratory, Oak Ridge, Tennessee; 3University of Nevada Reno, Reno, Nevada; 4University of Plymouth, Plymouth, UK; 5Harvard University, Cambridge, Massachusetts; 6 CCidental College, Los Angeles, California; 7Woods Hole Oceanographic Institute, Woods Hole, Massachusetts; 8National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; 9New York University Medical Center, Tuxedo, New York; 10Massachusetts Institute of Technology, Cambridge, Massachusetts Participants at the Napa Conference on Genetic and Molecular Ecotoxicology assessed the status of this field in light of heightened concerns about the genetic effects of exposure to hazardous substances and recent advancements in our capabilities to measure those effects. We present here a synthesis of the ideas discussed throughout the conference, including definitions of important concepts in the field and critical research needs and opportunities. While there were many opinions expressed on these topics, there was general agreement that there are substantive new opportuni- ties to improve the impact of genetic and molecular ecotoxicology on prediction of sublethal effects of exposure to hazardous substances. Future studies should emphasize integration of genetic ecotoxicology, ecological genetics, and molecular biology and should be directed toward improving our understanding of the ecological implications of genotoxic responses. Ecological implications may be assessed at either the population or ecosys- tem level; however, a population-level focus may be most pragmatic. -
Shortcomings of the Laboratory-Derived Median Lethal Concentration for Predicting Mortality in Field Populations: Exposure Duration and Latent Mortality
Environmental Toxicology and Chemistry, Vol. 23, No. 9, pp. 2147±2153, 2004 q 2004 SETAC Printed in the USA 0730-7268/04 $12.00 1 .00 SHORTCOMINGS OF THE LABORATORY-DERIVED MEDIAN LETHAL CONCENTRATION FOR PREDICTING MORTALITY IN FIELD POPULATIONS: EXPOSURE DURATION AND LATENT MORTALITY YUAN ZHAO* and MICHAEL C. NEWMAN Department of Environmental and Aquatic Animal Health, Virginia Institute of Marine Science, College of William and Mary, P.O. Box 1346, Gloucester Point, Virginia 23062-1346, USA (Received 15 October 2003; Accepted 9 February 2004) AbstractÐExposure duration and intensity (concentration or dose) determine lethal effects of toxicants. However, environmental regulators have focused on exposure intensity and have considered duration only peripherally. Conventional testing for toxicology tends to ®x exposure time and to use the median lethal concentration (LC50) at that time to quantify mortality. Fixing the exposure duration and selecting the 50% mortality level for reasons of statistical and logistical convenience result in the loss of ecologically relevant information generated at all other times and ignore latent mortality that manifests after the exposure ends. In the present study, we used survival analysis, which is widely employed in other ®elds, to include both time and concentration as covariates and to quantify latent mortality. This was done with two contrasting toxicants, copper sulfate (CuSO4) and sodium pentachlorophenol (NaPCP). Amphipods (Hyalella azteca) were exposed to different toxicant concentrations, and the percentage mortalities were noted both during and after the exposure ended. For CuSO4 at the conventional 48-h LC50 concentrations, the predicted proportions dead after including latent mortality were 65 to 85%, not 50%. -
European Centre for Ecotoxicology and Toxicology of Chemicals
EUROPEAN CENTRE FOR ECOTOXICOLOGY AND TOXICOLOGY OF CHEMICALS EUROPEAN CENTRE FOR ECOTOXICOLOGY AND TOXICOLOGY OF CHEMICALS ECETOC at a glance 2 Purpose 3 Values 3 Vision 3 Mission 3 Approach 3 Membership 4 ECETOC Member Companies 4 Membership benefits 5 Message from the Chairman 6 ECETOC Board of Administration 7 Report from the Secretary General 8 Science Programme 10 Foreword from the Scientific Committee Chairman 10 ECETOC revises its science strategy 11 Summary of the 2011 Science Programme 12 Highlights of 2011 15 Task forces established 16 Task forces completed 18 Workshops 21 Symposia and other meetings 24 Science Awards 28 Long-range Research Initiative 29 Communication 31 Publications 31 Online communication 32 External Representation 32 Members of the Scientific Committee 34 Members of the Secretariat 34 Finance 35 Abbreviations 36 ECETOC I European Centre for Ecotoxicology and Toxicology of Chemicals I Annual Report 2011 I page 2 Introduction Membership Message Board of Report from Science Science Long-range Communication Members of Finance Abbreviations from the Administration the Secretary Programme Awards Research the Scientific Chairman General Initiative Committee Established in 1978, ECETOC is Europe’s leading industry association for developing and promoting top quality science in human and environmental risk assessment of chemicals. Members include the main companies with interests in the manufacture and use of chemicals, biomaterials and pharmaceuticals, and organisations active in these fields. ECETOC is the scientific forum where member company experts meet and co-operate with government and academic scientists, to evaluate and assess the available data, identify gaps in knowledge and recommend research, and publish critical reviews on the ecotoxicology and toxicology of chemicals, biomaterials and pharmaceuticals. -
Toxicity and Assessment of Chemical Mixtures
Toxicity and Assessment of Chemical Mixtures Scientific Committee on Health and Environmental Risks SCHER Scientific Committee on Emerging and Newly Identified Health Risks SCENIHR Scientific Committee on Consumer Safety SCCS Toxicity and Assessment of Chemical Mixtures The SCHER approved this opinion at its 15th plenary of 22 November 2011 The SCENIHR approved this opinion at its 16th plenary of 30 November 2011 The SCCS approved this opinion at its 14th plenary of 14 December 2011 1 Toxicity and Assessment of Chemical Mixtures About the Scientific Committees Three independent non-food Scientific Committees provide the Commission with the scientific advice it needs when preparing policy and proposals relating to consumer safety, public health and the environment. The Committees also draw the Commission's attention to the new or emerging problems which may pose an actual or potential threat. They are: the Scientific Committee on Consumer Safety (SCCS), the Scientific Committee on Health and Environmental Risks (SCHER) and the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) and are made up of external experts. In addition, the Commission relies upon the work of the European Food Safety Authority (EFSA), the European Medicines Agency (EMA), the European Centre for Disease prevention and Control (ECDC) and the European Chemicals Agency (ECHA). SCCS The Committee shall provide opinions on questions concerning all types of health and safety risks (notably chemical, biological, mechanical and other physical risks) of non- food consumer products (for example: cosmetic products and their ingredients, toys, textiles, clothing, personal care and household products such as detergents, etc.) and services (for example: tattooing, artificial sun tanning, etc.). -
ECETOC Guidance on Dose Selection
ECETOC Guidance on Dose Selection Technical Report No. 138 EUROPEAN CENTRE OFOR EC TOXICOLOGY AND TOXICOLOGY OF CHEMICALS ECETOC Guidance on Dose Selection ECETOC Guidance on Dose Selection Technical Report No. 138 Brussels, March 2021 ISSN-2079-1526-138 (online) ECETOC TR No. 138 1 ECETOC Guidance on Dose Selection 224504 ECETOC Technical Report No. 138 © Copyright – ECETOC AISBL European Centre for Ecotoxicology and Toxicology of Chemicals Rue Belliard 40, B-1040 Brussels, Belgium. All rights reserved. No part of this publication may be reproduced, copied, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the copyright holder. Applications to reproduce, store, copy or translate should be made to the Secretary General. ECETOC welcomes such applications. Reference to the document, its title and summary may be copied or abstracted in data retrieval systems without subsequent reference. The content of this document has been prepared and reviewed by experts on behalf of ECETOC with all possible care and from the available scientific information. It is provided for information only. ECETOC cannot accept any responsibility or liability and does not provide a warranty for any use or interpretation of the material contained in the publication. ECETOC TR No. 138 2 ECETOC Guidance on Dose Selection ECETOC Guidance on Dose Selection Table of Contents 1. SUMMARY 6 2. INTRODUCTION, BACKGROUND AND PRINCIPLES 9 2.1. Background and Principles 9 2.2. Current Regulatory Framework and Guidance 10 2.2.1. Historical perspectives and the evolution of test guidelines 10 2.2.2. -
Wildlife Toxicology: Environmental Contaminants and Their National and International Regulation" (2012)
University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln USGS Staff -- ubP lished Research US Geological Survey 2012 Wildlife Toxicology: Environmental Contaminants and Their aN tional and International Regulation K. Christiana Grim Center for Species Survival, Smithsonian Conservation Biology Institute Anne Fairbrother EcoSciences Barnett A. Rattner U.S. Geological Survey, [email protected] Follow this and additional works at: http://digitalcommons.unl.edu/usgsstaffpub Part of the Geology Commons, Oceanography and Atmospheric Sciences and Meteorology Commons, Other Earth Sciences Commons, and the Other Environmental Sciences Commons Grim, K. Christiana; Fairbrother, Anne; and Rattner, Barnett A., "Wildlife Toxicology: Environmental Contaminants and Their National and International Regulation" (2012). USGS Staff -- Published Research. 969. http://digitalcommons.unl.edu/usgsstaffpub/969 This Article is brought to you for free and open access by the US Geological Survey at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in USGS Staff -- ubP lished Research by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. Published in New Directions in Conservation Medicine: Applied Cases in Ecological Health, edited by A. Alonso Aguirre, Richard S. Ostfield, and Peter Daszak (New York: Oxford University Press, 2012). Authors K. Christiana Grim, D.V.M. Research Associate Center for Species Survival Smithsonian Conservation Biology Institute Front Royal, Vrrginia Anne Fairbrother, D.V.M., M.S., Ph.D. Senior Managing Scientist EcoSciences Exponent Seattle, Washington Barnett A. Rattner, Ph.D. Ecotoxicologist U.S. Geological Survey Patuxent Wildlife Research Center Beltsville Laboratory Beltsville, Maryland WILDLIFE TOXICOLOGY Environmental Contaminants and Their National and International Regulation K. Christiana Grim, Anne Fairbrother, and Barnett A. -
Ecotoxicology Knowledgebase
ECOTOXicology Knowledgebase: Modernizing the Literature Review and Data Curation Processes, and Mapping Ecological Toxicity of Per- and Polyfluoroalkyl Substances (PFAS) Jennifer OlkerPhoto, image Postdoctoral area measures 2” H x 6.93” W and can be Researchermasked by a collage strip of one, two or three images. Colleen ElonenThe photo, imageECOTOX area is located 3.19” from coordinator left and 3.81” from top of page. Each image used in collage should be reduced or cropped to a maximum of 2” high, stroked with a 1.5 pt white frame and positioned edge-to-edge with accompanying images. US EPA ECOTOX Project Team: Colleen Elonen Jennifer Olker GDIT contract staff Dale Hoff SEE staff Rong-Lin Wang Office of Research and Development www.epa.gov/ecotox Overview • Background and History for ECOTOX Knowledgebase • Modernizing the ECOTOX Pipeline (C. Elonen, SOT 2020) • Mapping ecological toxicity of PFAS with ECOTOX Protocols (J. Olker, SOT 2020) 2 What is the ECOTOX Knowledgebase? Publicly available, curated database providing toxicity data from single-chemical exposure studies to aquatic life, terrestrial plants, and wildlife • From comprehensive search and review of open and grey literature – Data extracted from acceptable studies, with up to 250 fields – Updated quarterly • 30+ year history: www.epa.gov/ecotox/ Originated in the early 1980s, US Environmental Protection Agency Office of Research and Development 3 Who uses the ECOTOX Knowledgebase? Clients Contacting ECOTOX Support line 2005 - 2016 (n = 2813) US EPA Headquarters Local Govt. International Govt. 4% 1% 8% Govt. Contractors 25% US EPA Regional Office 4% Unknown 5% University/Academia Other Federal 6% Agencies 4% US EPA Laboratory 4% State Govt. -
Lecture Notes on Toxicology
LECTURE NOTES For Medical Laboratory Science Students Toxicology Dr. Biruh Alemu (MD), Ato Mistire Wolde (MSC, MSC) Hawassa University In collaboration with the Ethiopia Public Health Training Initiative, The Carter Center, the Ethiopia Ministry of Health, and the Ethiopia Ministry of Education May 2007 Funded under USAID Cooperative Agreement No. 663-A-00-00-0358-00. Produced in collaboration with the Ethiopia Public Health Training Initiative, The Carter Center, the Ethiopia Ministry of Health, and the Ethiopia Ministry of Education. Important Guidelines for Printing and Photocopying Limited permission is granted free of charge to print or photocopy all pages of this publication for educational, not-for-profit use by health care workers, students or faculty. All copies must retain all author credits and copyright notices included in the original document. Under no circumstances is it permissible to sell or distribute on a commercial basis, or to claim authorship of, copies of material reproduced from this publication. ©2007 by Dr. Biruh Alemu, Ato Misire Wolde All rights reserved. Except as expressly provided above, no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without written permission of the author or authors. This material is intended for educational use only by practicing health care workers or students and faculty in a health care field. PREFACE The scope of toxicology widened tremendously during the last few years. An important development in this discipline is mandatory because of the expansion of different industrial, medical, environmental, animal and plant noxious substances. -
APPENDIX O10 Ecotoxicology Studies
APPENDIX O10 Ecotoxicology studies Olympic Dam Expansion Draft Environmental Impact Statement 2009 Appendix O 163 AAppendix_O_Vol_1.inddppendix_O_Vol_1.indd Sec1:163Sec1:163 117/2/097/2/09 11:08:33:08:33 AMAM AAppendix_O_Vol_1.inddppendix_O_Vol_1.indd Sec1:164Sec1:164 117/2/097/2/09 11:08:34:08:34 AMAM O10 ECOTOXICOLOGY STUDIES O10.1 INTRODUCTION The toxicity of simulated brine was tested using 15 species of marine flora and fauna. The tests were managed by Hydrobiology and Geotechnical Services and undertaken in laboratories in Sydney, Adelaide and Perth during 2006 and 2007. A suite of species from Upper Spencer Gulf, or surrogates for which recognised tests were available, were tested using both chronic and acute tests by Hydrobiology in 2006. These tests are presented in Appendix O10.2. Toxicity tests were developed for the Australian Giant Cuttlefish Sepia apama by Geotechnical Services in 2006. These tests are presented in Appendix O10.3. Following a review of the 2006 reports, additional tests were undertaken in 2007 to include more local species, chronic rather than acute tests, and a consistent diluent salinity (41 g/L), and to repeat the Giant Cuttlefish tests. The 2007 tests are presented in Appendix O10.4. Several interim species protection trigger values (SPTV) were calculated using the three suites of toxicity tests. The CSIRO subsequently reviewed all the tests and calculated an overall SPTV using the most appropriate species and tests. The CSIRO’s assessment is presented in Appendix O10.5. Dr Michael Warne of the CSIRO has also provided a peer review letter of testimony for the ecotoxicological studies undertaken for the Draft EIS (see overleaf). -
Persistent Organic Pollutants (Pops): State of the Science
Environmental Pollution 100 (1999) 209±221 www.elsevier.com/locate/envpol Persistent organic pollutants (POPs): state of the science K.C. Jones a,*, P. de Voogt b aEnvironmental Science Department, Institute of Environmental and Natural Sciences, Lancaster University, Lancaster, LA1 4YQ, UK bDepartment of Environmental and Toxicological Chemistry, Amsterdam Research Institute for Substances in Ecosystems (ARISE), University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, Netherlands Received 15 November 1998; accepted 22 March 1999 Abstract The environmental chemistry and ecotoxicology of persistent organic pollutants (POPs) are fascinating areas of scienti®c research. Our objective in this paper is to provide a brief, focussed overview of what constitutes a POP, highlight the harmful eects they may have on biota, make some comments on their environmental sources and analysis, their environmental trends and pro- cesses, their movement through foodchains and highlight some important regional-and global-scale environmental transport issues. Finally, we oer some personal thoughts on some current and future areas of scienti®c enquiry on POPs. # 1999 Elsevier Science Ltd. All rights reserved. Keywords: Persistent organic pollutant, POP; Sources; Air±surface exchange; Biota; Foodchains 1. What are Persistent Organic Pollutants (POPs) and They also partition into lipids in organisms rather than their properties? entering the aqueous milieu of cells and become stored in fatty tissue. This confers persistence on the chemical There are many thousands of POP chemicals, often in biota since metabolism is slow and POPs may there- coming from certain series or `families' of chemicals (e.g fore accumulate in foodchains. there are theoretically 209 dierent polychlorinated Importantly, POPs have the propensity to enter the biphenyls, diering from each other by level of chlor- gas phase under environmental temperatures.