Polyclonal Antibody to SERPINA6

AP10406PU-N OriGene Technologies Inc. OriGene EU

Acris Antibodies GmbH 9620 Medical Center Drive, Ste 200 Schillerstr. 5 Rockville, MD 20850 32052 Herford UNITED STATES GERMANY Phone: +1-888-267-4436 Phone: +49-5221-34606-0 Fax: +1-301-340-8606 Fax: +49-5221-34606-11 [email protected] [email protected]

Polyclonal Antibody to SERPINA6 / CBG - Aff - Purified Alternate names: Corticosteroid-binding globulin, Serpin A6, Transcortin Catalog No.: AP10406PU-N Quantity: 0.1 mg Concentration: 0.5 mg/ml Background: Cortisol Binding Globulin, Human (SERPINA6, CBG, Transcortin, Corticosteroid Binding Globulin) is a serum glycoprotein, belonging to the serpin family and synthesized in the liver. It is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The CBG gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. Uniprot ID: P08185 NCBI: NP_001747.2 GeneID: 866 Host: Goat Immunogen: Peptide with sequence C-DLFTNQANFSRIT, from the internal region of the protein sequence according to NP_001747.2. Format: State: Liquid purified IgG fraction. Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide. Buffer System: Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer. Applications: Peptide ELISA: Detection Limit Dilution: 1/1000. Immunohistochemistry: 3-6 µg/ml. In Paraffin Embededd Human Uterus shows brush border staining of endometrial glands. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Specificity: Recognizes SERPINA6/CBG. Species Reactivity: Tested: Human. Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. General Readings: 1. Torpy DJ, Ho JT. Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders. Clin Endocrinol (Oxf). 2007 Aug;67(2):161-7. Epub 2007 Jun 4. Review.

For research and in vitro use only. Not for diagnostic or therapeutic work. OG/20130814 Material Safety Datasheets are available at www.acris-antibodies.com or on request. Acris Antibodies is now part of the OriGene family. Learn more at www.origene.com 1 / 2 AP10406PU-N: Polyclonal Antibody to SERPINA6 / CBG - Aff - Purified Pictures: SERPINA6 Antibody (AP10406PU-N at 3.8 µg/ml) staining of paraffin embedded Human Uterus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.