Polyclonal Antibody to SERPINA6

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AP10406PU-N OriGene Technologies Inc. OriGene EU Acris Antibodies GmbH 9620 Medical Center Drive, Ste 200 Schillerstr. 5 Rockville, MD 20850 32052 Herford UNITED STATES GERMANY Phone: +1-888-267-4436 Phone: +49-5221-34606-0 Fax: +1-301-340-8606 Fax: +49-5221-34606-11 [email protected] [email protected] Polyclonal Antibody to SERPINA6 / CBG - Aff - Purified Alternate names: Corticosteroid-binding globulin, Serpin A6, Transcortin Catalog No.: AP10406PU-N Quantity: 0.1 mg Concentration: 0.5 mg/ml Background: Cortisol Binding Globulin, Human (SERPINA6, CBG, Transcortin, Corticosteroid Binding Globulin) is a serum glycoprotein, belonging to the serpin family and synthesized in the liver. It is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The CBG gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. Uniprot ID: P08185 NCBI: NP_001747.2 GeneID: 866 Host: Goat Immunogen: Peptide with sequence C-DLFTNQANFSRIT, from the internal region of the protein sequence according to NP_001747.2. Format: State: Liquid purified IgG fraction. Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide. Buffer System: Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer. Applications: Peptide ELISA: Detection Limit Dilution: 1/1000. Immunohistochemistry: 3-6 µg/ml. In Paraffin Embededd Human Uterus shows brush border staining of endometrial glands. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Specificity: Recognizes SERPINA6/CBG. Species Reactivity: Tested: Human. Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. General Readings: 1. Torpy DJ, Ho JT. Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders. Clin Endocrinol (Oxf). 2007 Aug;67(2):161-7. Epub 2007 Jun 4. Review. For research and in vitro use only. Not for diagnostic or therapeutic work. OG/20130814 Material Safety Datasheets are available at www.acris-antibodies.com or on request. Acris Antibodies is now part of the OriGene family. Learn more at www.origene.com 1 / 2 AP10406PU-N: Polyclonal Antibody to SERPINA6 / CBG - Aff - Purified Pictures: SERPINA6 Antibody (AP10406PU-N at 3.8 µg/ml) staining of paraffin embedded Human Uterus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. For research and in vitro use only. Not for diagnostic or therapeutic work. OG/20130814 Material Safety Datasheets are available at www.acris-antibodies.com or on request. Acris Antibodies is now part of the OriGene family. Learn more at www.origene.com 2 / 2 Powered by TCPDF (www.tcpdf.org).

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Plasminogen Activator Inhibitor Type-1
PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1: structure-function studies and its use as a reference for intramolecular distance measurements by Peter Hägglöf Department of Medical Biochemistry and Biophysics Umeå University, Sweden Umeå 2004 1 Copyright 2003 Peter Hägglöf Printed in Sweden by VMC-KBC New Series No. 869; ISSN 0346-6612; ISBN 91-7305-571 2 TABLE OF CONTENTS ABBREVIATIONS 4 ABSTRACT 5 PREFACE 6 INTRODUCTION 7 1. General overview 7 2. Serine proteases 8 2.1 Plasmin 9 2.2 Urokinase-type plasminogen activator (uPA) 9 2.3 Tissue-type plasminogen activator (tPA) 10 3. Serpin structure 10 3.1 Introduction 11 3.2 Active form 11 3.3 Cleaved form 12 3.4 Latent form 12 4. The inhibitory mechanism of serpins 12 5. PAI-1 13 5.1 Expression 13 5.2 Inhibitory activity 13 5.3 Cofactors 14 5.3.1 heparin 14 5.3.2 vitronectin 14 5.4 Structural instability of PAI-1 14 5.5 Regulation of cell migration 15 5.6 Diseases related to PAI-1 15 6. Structure determination of proteins by fluorescence spectroscopy 15 6.1 Basic concept of fluorescence 16 6.2 Fluorescence lifetime 16 6.3 Fluorescence anisotropy 17 6.4 Energy transfer 17 6.5 Fluorescent probes 17 6.5.1 Intrinsic fluorophores 18 6.5.2 Extrinsic fluorophores 18 6.6 Donor-acceptor energy transfer (DAET) 18 6.7 Donor-Donor Energy Migration DDEM 19 6.8 Quenching of BODIPY dimmers 19 7. Summary of the present study 19 7.1 The use of site-directed fluorophore labeling and donor-donor energy migration to investigate solution structure and dynamics in proteins (Paper I) 19 7.2 Dimers of dipyrrometheneboron difluoride (BODIPY) with light spectroscopic applications in chemistry and biology.
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Human Alpha 2 Antiplasmin (Total) ELISA Kit (ARG81079)
Product datasheet [email protected] ARG81079 Package: 96 wells Human alpha 2 Antiplasmin (total) ELISA Kit Store at: 4°C Summary Product Description ARG81079 alpha 2 Human Antiplasmin (total) ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Antiplasmin (total) in plasma. Tested Reactivity Hu Tested Application ELISA Target Name alpha 2 Antiplasmin Conjugation HRP Conjugation Note TMB substrate is used for color development at 450 nm. Sensitivity 0.028 ng/ml Sample Type Plasma Standard Range 0.1 - 100 ng/ml Alternate Names Alpha-2-AP; Serpin F2; Alpha-2-PI; Alpha-2-antiplasmin; Alpha-2-plasmin inhibitor; AAP; API; PLI; A2AP; ALPHA-2-P Properties Form 96 well Storage instruction Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. Note For laboratory research only, not for drug, diagnostic or other use. Bioinformation Database links GeneID: 5345 Human Swiss-port # P08697 Human Gene Symbol SERPINF2 Gene Full Name serpin family F member 2 Background This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene.
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The Plasmin–Antiplasmin System: Structural and Functional Aspects
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Bern Open Repository and Information System (BORIS) Cell. Mol. Life Sci. (2011) 68:785–801 DOI 10.1007/s00018-010-0566-5 Cellular and Molecular Life Sciences REVIEW The plasmin–antiplasmin system: structural and functional aspects Johann Schaller • Simon S. Gerber Received: 13 April 2010 / Revised: 3 September 2010 / Accepted: 12 October 2010 / Published online: 7 December 2010 Ó Springer Basel AG 2010 Abstract The plasmin–antiplasmin system plays a key Plasminogen activator inhibitors Á a2-Macroglobulin Á role in blood coagulation and fibrinolysis. Plasmin and Multidomain serine proteases a2-antiplasmin are primarily responsible for a controlled and regulated dissolution of the fibrin polymers into solu- Abbreviations ble fragments. However, besides plasmin(ogen) and A2PI a2-Antiplasmin, a2-Plasmin inhibitor a2-antiplasmin the system contains a series of specific CHO Carbohydrate activators and inhibitors. The main physiological activators EGF-like Epidermal growth factor-like of plasminogen are tissue-type plasminogen activator, FN1 Fibronectin type I which is mainly involved in the dissolution of the fibrin K Kringle polymers by plasmin, and urokinase-type plasminogen LBS Lysine binding site activator, which is primarily responsible for the generation LMW Low molecular weight of plasmin activity in the intercellular space. Both activa- a2M a2-Macroglobulin tors are multidomain serine proteases. Besides the main NTP N-terminal peptide of Pgn physiological inhibitor a2-antiplasmin, the plasmin–anti- PAI-1, -2 Plasminogen activator inhibitor 1, 2 plasmin system is also regulated by the general protease Pgn Plasminogen inhibitor a2-macroglobulin, a member of the protease Plm Plasmin inhibitor I39 family.
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Regulation of Lymphocyte Proliferation by Uterine Serpin: Interleukin-2 Mrna Production, CD25 Expression and Responsiveness to Interleukin-2 (44465) 2 1 MORGAN R
Regulation of Lymphocyte Proliferation by Uterine Serpin: Interleukin-2 mRNA Production, CD25 Expression and Responsiveness to Interleukin-2 (44465) 2 1 MORGAN R. PELTIER,WEN-JUN LIU, AND PETER J. HANSEN Department of Dairy and Poultry Sciences, University of Florida, Gainesville, Florida 32611–0920 Abstract. During pregnancy, the endometrium of the ewe secretes large amounts of a progesterone-induced protein of the serpin superfamily of serine proteinase inhibitors called ovine uterine serpin (OvUS). This protein inhibits lymphocyte proliferation in response to concanavalin A (ConA), phytohemagglutinin (PHA), or mixed lymphocyte reaction. The purpose of these experiments was to characterize the mechanism by which OvUS inhibits lymphocyte proliferation. Ovine US caused dose-dependent in- hibition of lymphocyte proliferation induced by phorbol myristol acetate (PMA), an activator of protein kinase C. The PHA-induced increase in CD25 expression was inhibited in peripheral blood mononuclear leukocytes (PBML) by OvUS. However, no effect of OvUS on Con A-induced expression of CD25 was observed. Further analysis using two-color flow cytometry revealed that OvUS inhibited ConA-induced expres- sion of CD25 in ␥␦-TCR− cells but not ␥␦-TCR+ cells. Stimulation of PBML for 14 hr with ConA resulted in an increase in steady state amounts of interleukin-2 (IL-2) mRNA that was not inhibited by OvUS. Ovine US was also inhibitory to lymphocyte proliferation induced by human IL-2. Results suggest that OvUS acts to inhibit lymphocyte prolif- eration by blocking the upregulation of the IL-2 receptor and inhibiting IL-2–mediated events. Lack of an effect of OvUS on ConA-stimulated CD25 expression in ␥␦-TCR+ cells may reflect a different mechanism of activation of these cells or insensitivity to inhibition by OvUS.
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Antiplasmin the Main Plasmin Inhibitor in Blood Plasma
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Overexpression of Plasminogen Activator Inhibitor Type 2 in Basal Keratinocytes Enhances Papilloma Formation in Transgenic Mice1
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A Dissertation Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy
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