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Jcsmr Annual Report 2005.Pdf THE JOHN CURTIN SCHOOL OF MEDICAL RESEARCH Annual Review 2005 Health Through Discovery Introduction Researchers in The John Curtin School of Medical Research at The Australian National University continue to strive towards Howard Florey’s vision – of a national medical research school undertaking superlative medical research in fundamental areas. Opened in 1958, the School has almost 50 years of prize winning research, including three Nobel Prize medals in Physiology or Medicine, The Japan Prize, The Copley Medal, and The Prime Minister’s Prize for Science. The School is organised into three major research divisions, Molecular Bioscience, Immunology and Genetics, and Neuroscience, each comprised of independent groups and laboratories. The High Blood Pressure Research Unit is headed by the School’s Director. A unique feature and major strength of JCSMR is the diverse nature of the research programs, including genomics, immunity, gene regulation and cell signalling, neuroscience and integrative physiology. These areas benefit enormously from the potential for mutual interaction and collaboration across Divisions, enabling the School to make important contributions to the understanding of many diseases, including diabetes, cancer, asthma and high blood pressure, infectious disease, hearing, vision and memory. We are committed to training medical researchers of the future, with students drawn from Australia and overseas. Many of our postgraduate students are carrying out research directed towards a PhD degree; however JCSMR also shares supervision of Honours students with the ANU Faculties and other institutions. 1 Table of Contents JCSMR 2005 JCSMR 2005 From the Director Introduction to The John Curtin School of Medical Research It gives me great pleasure to present The John Curtin School of Medical Research Annual From the Director . 3 Review for 2005. Highlights . 4 Outcomes . 5 The Review provides a snapshot of the previous year, describing research highlights and JCSMR Structure . 6 outcomes, and detailing prizes, awards, publications and other activities carried out by staff Boards and Committees . 7 and students of the School during 2005. 9 Research Programs . The past year has been extremely successful for researchers within the School. Professor Division of Immunology and Genetics . 10 Division of Molecular Bioscience . .15 Christopher Parish received The Clive and Vera Ramaciotti Medal for Excellence in Biomedical Division of Neuroscience . .20 Science. Professor Christopher Goodnow was awarded the Commonwealth Health Minister’s Prize for Excellence in Health and Medical Research. Professor Ian Young accepted the Staff & Student Achievements . 25 Lemberg Medal, presented by the Australian Society for Biochemistry and Molecular Biology. Research Collaborations & Visitors . 29 We were pleased to award the second Curtin Medal to Professor Ian Frazer of The University Research Collaborations . .30 of Queensland for his achievements in the development of a cancer vaccine. Visitors to JCSMR . .38 Throughout the year, research continued as the back of our building became a construction Staff, Students & Invited Presentations . 41 zone. The outside shell, and all the major structural elements of Stage 1 of our new building Division of Immunology and Genetics . .42 were completed during 2005, and we watched in excitement as the building grew. We look Division of Molecular Bioscience . .43 Division of Neuroscience . .52 forward to moving into the new, state of the art laboratories in mid-2006. Throughout this High Blood Pressure Research Unit . .55 report, glimpses of the building process are used as illustration. Students . .56 School Administration and Services . .58 We congratulate Professor Frank Fenner, ACT Senior Australian of the Year for 2006, and an inspiration to us all. Publications . 61 Contact with our Community . 69 Judith A Whitworth AC Voluntary Service to Organisations outside JCSMR . .73 Support . 76 Grants . .78 Statistics . .82 Donors . .83 Strategic Goals of The John Curtin School of Medical Research • Conduct research of the highest international standard into fundamental life processes and the pathologies of these processes which cause human disease • Play a leadership role in medical research in Australia • Provide outstanding training in medical research for young scientists and health professionals • Apply new knowledge for better health outcomes 2 3 Highlights and Outcomes 2005 JCSMR 2005 JCSMR 2005 Highlights Significant Outcomes • Professor Christopher Parish (Division of Immunology and Genetics) • The Australian Phenomics Facility was officially opened by ANU Alumnus, was awarded the Clive and Vera Ramaciotti Medal for Excellence Senator Gary Humphries. The Facility houses the Australian Phenome Bank in Biomedical Science for his many fundamental contributions to which provides scientists around the country with easy access to genetically knowledge in the fields of immunology and cancer biology. modified strains of mice. • Professor Trevor Lamb (Division of Neuroscience) will Co-direct an ARC Centre of Excellence in Vision Science at The Australian National University. • Professor Christopher Goodnow (Division of Immunology and Genetics) This centre, funded by the ARC, will work to provide a deeper understanding was presented with the Commonwealth Health Minister’s Award for of the ways in which the visual system functions, how it extracts information Excellence in Health and Medical Research for his work in molecular genetics. about the world, and why it is that the eye is susceptible to degeneration. • The cancer therapeutic PI-88, the breakthrough treatment developed in the laboratory of Professor Christopher Parish and his team in the Division • Professor Ian Young (Division of Molecular Bioscience) was awarded The of Immunology and Genetics has gone into expanded clinical trials. In the Lemberg Medal by the Australian Society for Biochemistry and Molecular phase II trials currently underway, 650 patients with primary liver cancer, Biology in recognition of his sustained and excellent contribution to and advanced melanoma, lung and prostate cancer will be included. biochemistry and molecular biology. • A research team led by Dr Carola Garcia de Vinuesa (Division of Immunology and Genetics) has discovered a new gene thought to contribute to • The Curtin Medal was presented to Professor Ian Frazer for his autoimmune diseases such as Type 1 diabetes and lupus. The gene, which outstanding contribution to medical research through his development they have named Roquin, causes the body’s infection fighters, T cells, to of a vaccine to prevent cervical cancer. attack their own tissue. Potential treatments that target this mutation will now be explored. • We are committed to training medical researchers of the future. We congratulate the 10 PhD students and 15 Honours students who successfully completed their graduate studies during 2005. 4 5 JCSMR 2005 Boards & Committees 2005 JCSMR 2005 JCSMR Structure 2005 Faculty Board 2005 The Director (Chair), ex officio The Australian Australian Professor JA Whitworth Immunology and Genetics National University Phenomics Facility The Deputy Director, ex officio Professor SJ Redman The John Curtin School of Centre for Bioinformation Chair of Faculty, ex officio Molecular Bioscience Science Medical Research Professor IA Ramshaw Director The Convenor, Graduate Program in Medical Sciences, ex officio Dr VL Ross Neuroscience Head, Division of Immunology and Genetics, ex officio Professor CR Parish Research groups, units and laboratories groups, Research High Blood Pressure Head, Division of Molecular Bioscience, ex officio Research Unit Professor MF Shannon Head, Division of Neuroscience, ex officio Animal Services Professor C Hill (until September) Dr G Stuart (from October) Divisional representatives Biomolecular Director’s Office Dr D Webb (Molecular Bioscience) (until February) Resource Facility Dr A Blackburn (Molecular Bioscience) (from February) Dr G Karupiah (Immunology and Genetics) Dr C Raymond (Neuroscience) Financial and Research Information Technology Support and Communications Unit Graduate student representative Ms A Moore (until January) Mr K Brown (from February) General Services Microscopy and Mr G Sjollema (February-May) Services and Support Cytometry Facility General Staff representatives Administration Ms Michelle Townsend (from June) Human Resource Mr B Webb, Business Manager (from June) Management Technical Services By invitation Dr MJ Nicol, Public Affairs Manager Mr B Webb, Business Manager (until May) Student Convenor Media and Washup 6 7 The Director of The John Curtin School of Medical The Research Advisory Board of The John Curtin School Research receives advice from a Strategic Advisory of Medical Research reviews both current Committee on matters such as administration and and potential research initiatives and programs within management, fundraising, commercialization of the School, and provides advice to the Director as to research and raising the profile of JCSMR nationally how these programs might advance. JCSMR 2005 and internationally. Strategic Advisory Committee Research Advisory Board Research Programs Director, JCSMR (Chair), ex officio Director, JCSMR (Chair), ex officio Deputy Director, JCSMR, ex officio Deputy Director, JCSMR, ex officio The John Curtin School of Medical Research is made up Sir David Akers-Jones, Hong Kong Deputy Vice-Chancellor (Research), ANU, ex officio of three Divisions: Immunology and Genetics, Molecular Chair, JCSMR
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