THE JOHN CURTIN SCHOOL OF

Annual Review 2005

Health Through Discovery Introduction

Researchers in The John Curtin School of Medical Research at National University continue to strive towards Howard Florey’s vision – of a national medical research school undertaking superlative medical research in fundamental areas. Opened in 1958, the School has almost 50 years of prize winning research, including three Nobel Prize medals in Physiology or , The Japan Prize, The Copley Medal, and The Prime Minister’s Prize for Science.

The School is organised into three major research divisions, Molecular Bioscience, and Genetics, and Neuroscience, each comprised of independent groups and laboratories. The High Blood Pressure Research Unit is headed by the School’s Director. A unique feature and major strength of JCSMR is the diverse nature of the research programs, including genomics, immunity, gene regulation and cell signalling, neuroscience and integrative physiology. These areas benefit enormously from the potential for mutual interaction and collaboration across Divisions, enabling the School to make important contributions to the understanding of many diseases, including diabetes, cancer, asthma and high blood pressure, infectious disease, hearing, vision and memory.

We are committed to training medical researchers of the future, with students drawn from Australia and overseas. Many of our postgraduate students are carrying out research directed towards a PhD degree; however JCSMR also shares supervision of Honours students with the ANU Faculties and other institutions.

1 Table of Contents JCSMR 2005 JCSMR 2005

From the Director

Introduction to The John Curtin School of Medical Research It gives me great pleasure to present The John Curtin School of Medical Research Annual From the Director ...... 3 Review for 2005. Highlights ...... 4 Outcomes ...... 5 The Review provides a snapshot of the previous year, describing research highlights and JCSMR Structure ...... 6 outcomes, and detailing prizes, awards, publications and other activities carried out by staff Boards and Committees ...... 7 and students of the School during 2005. 9 Research Programs ...... The past year has been extremely successful for researchers within the School. Professor Division of Immunology and Genetics ...... 10 Division of Molecular Bioscience ...... 15 Christopher Parish received The Clive and Vera Ramaciotti Medal for Excellence in Biomedical Division of Neuroscience ...... 20 Science. Professor Christopher Goodnow was awarded the Commonwealth Health Minister’s Prize for Excellence in Health and Medical Research. Professor Ian Young accepted the Staff & Student Achievements ...... 25 Lemberg Medal, presented by the Australian Society for Biochemistry and . Research Collaborations & Visitors ...... 29 We were pleased to award the second Curtin Medal to Professor Ian Frazer of The University Research Collaborations ...... 30 of Queensland for his achievements in the development of a cancer . Visitors to JCSMR ...... 38 Throughout the year, research continued as the back of our building became a construction Staff, Students & Invited Presentations ...... 41 zone. The outside shell, and all the major structural elements of Stage 1 of our new building Division of Immunology and Genetics ...... 42 were completed during 2005, and we watched in excitement as the building grew. We look Division of Molecular Bioscience ...... 43 Division of Neuroscience ...... 52 forward to moving into the new, state of the art laboratories in mid-2006. Throughout this High Blood Pressure Research Unit ...... 55 report, glimpses of the building process are used as illustration. Students ...... 56 School Administration and Services ...... 58 We congratulate Professor Frank Fenner, ACT Senior for 2006, and an inspiration to us all. Publications ...... 61

Contact with our Community ...... 69 Judith A Whitworth AC Voluntary Service to Organisations outside JCSMR ...... 73

Support ...... 76 Grants ...... 78 Statistics ...... 82 Donors ...... 83 Strategic Goals of The John Curtin School of Medical Research • Conduct research of the highest international standard into fundamental life processes and the pathologies of these processes which cause human disease • Play a leadership role in medical research in Australia • Provide outstanding training in medical research for young scientists and health professionals • Apply new knowledge for better health outcomes

2 3 Highlights and Outcomes 2005 JCSMR 2005 JCSMR 2005

Highlights Significant Outcomes

• Professor Christopher Parish (Division of Immunology and Genetics) • The Australian Phenomics Facility was officially opened by ANU Alumnus, was awarded the Clive and Vera Ramaciotti Medal for Excellence Senator Gary Humphries. The Facility houses the Australian Phenome Bank in Biomedical Science for his many fundamental contributions to which provides scientists around the country with easy access to genetically knowledge in the fields of immunology and cancer biology. modified strains of mice. • Professor Trevor Lamb (Division of Neuroscience) will Co-direct an ARC Centre of Excellence in Vision Science at The Australian National University. • Professor Christopher Goodnow (Division of Immunology and Genetics) This centre, funded by the ARC, will work to provide a deeper understanding was presented with the Commonwealth Health Minister’s Award for of the ways in which the visual system functions, how it extracts information Excellence in Health and Medical Research for his work in molecular genetics. about the world, and why it is that the eye is susceptible to degeneration. • The cancer therapeutic PI-88, the breakthrough treatment developed in the laboratory of Professor Christopher Parish and his team in the Division • Professor Ian Young (Division of Molecular Bioscience) was awarded The of Immunology and Genetics has gone into expanded clinical trials. In the Lemberg Medal by the Australian Society for Biochemistry and Molecular phase II trials currently underway, 650 patients with primary liver cancer, Biology in recognition of his sustained and excellent contribution to and advanced melanoma, lung and prostate cancer will be included. biochemistry and molecular biology. • A research team led by Dr Carola Garcia de Vinuesa (Division of Immunology and Genetics) has discovered a new gene thought to contribute to • The Curtin Medal was presented to Professor Ian Frazer for his autoimmune diseases such as Type 1 diabetes and lupus. The gene, which outstanding contribution to medical research through his development they have named Roquin, causes the body’s infection fighters, T cells, to of a vaccine to prevent . attack their own tissue. Potential treatments that target this mutation will now be explored.

• We are committed to training medical researchers of the future. We congratulate the 10 PhD students and 15 Honours students who successfully completed their graduate studies during 2005.

4 5 JCSMR 2005 Boards & Committees 2005 JCSMR 2005

JCSMR Structure 2005 Faculty Board 2005

The Director (Chair), ex officio The Australian Australian Professor JA Whitworth Immunology and Genetics National University Phenomics Facility The Deputy Director, ex officio Professor SJ Redman

The John Curtin School of Centre for Bioinformation Chair of Faculty, ex officio Molecular Bioscience Science Medical Research Professor IA Ramshaw Director The Convenor, Graduate Program in Medical Sciences, ex officio Dr VL Ross Neuroscience Head, Division of Immunology and Genetics, ex officio Professor CR Parish Research groups, units and laboratories groups, Research High Blood Pressure Head, Division of Molecular Bioscience, ex officio Research Unit Professor MF Shannon Head, Division of Neuroscience, ex officio Animal Services Professor C Hill (until September) Dr G Stuart (from October) Divisional representatives Biomolecular Director’s Office Dr D Webb (Molecular Bioscience) (until February) Resource Facility Dr A Blackburn (Molecular Bioscience) (from February) Dr G Karupiah (Immunology and Genetics) Dr C Raymond (Neuroscience) Financial and Research Information Technology Support and Communications Unit Graduate student representative Ms A Moore (until January) Mr K Brown (from February) General Services Microscopy and Mr G Sjollema (February-May)

Services and Support Cytometry Facility General Staff representatives Administration Ms Michelle Townsend (from June) Human Resource Mr B Webb, Business Manager (from June) Management Technical Services By invitation Dr MJ Nicol, Public Affairs Manager Mr B Webb, Business Manager (until May) Student Convenor Media and Washup

6 7 The Director of The John Curtin School of Medical The Research Advisory Board of The John Curtin School Research receives advice from a Strategic Advisory of Medical Research reviews both current Committee on matters such as administration and and potential research initiatives and programs within management, fundraising, commercialization of the School, and provides advice to the Director as to research and raising the profile of JCSMR nationally how these programs might advance. JCSMR 2005 and internationally.

Strategic Advisory Committee Research Advisory Board Research Programs

Director, JCSMR (Chair), ex officio Director, JCSMR (Chair), ex officio Deputy Director, JCSMR, ex officio Deputy Director, JCSMR, ex officio The John Curtin School of Medical Research is made up Sir David Akers-Jones, Hong Kong Deputy Vice-Chancellor (Research), ANU, ex officio of three Divisions: Immunology and Genetics, Molecular Chair, JCSMR Faculty, ex officio Professor Peter Doherty AC, The University of Bioscience, and Neuroscience, and the High Blood Pressure , Melbourne, VIC Professor Jerry Adams, The Walter and Eliza Hall Research Unit. The Australian Phenomics Facility is a major Institute, Melbourne, VIC National Research Facility co-located with the School. Mr Alan Evans, Strategic Consulting Services, Within the Divisions, staff and students belong to Groups Canberra, ACT Professor Rob Baxter, Kolling Institute of Medical Research, Sydney, NSW (NHMRC nominee) or Laboratories. Members of these groups collaborate across Mr Peter Gordon, Canberra, ACT Professor Sam Berkovic, Austin and Repatriation Divisions within the School, and across The Australian National Ms Pru Goward, Federal Sex Discrimination Medical Centre, Melbourne, VIC University, as well as with colleagues in other institutions. Commissioner, Canberra, ACT Professor Ross Coppel, Monash University, In the following pages, we present a description of 12 of the Professor Colin Johnston AO, Baker Medical Research Melbourne, VIC current research projects being undertaken within the School. Institute, Melbourne, VIC Professor Tony D’Apice, Department of Clinical The Hon Dr Barry Jones AO, Melbourne, VIC Immunology, St Vincent’s Hospital, Melbourne, VIC Dr Denis W King, St George Private Medical Hospital, Professor Anne Kelso, Queensland Institute of Sydney, NSW Medical Research, , QLD Professor Kiaran Kirk, Faculty of Science, ANU, Associate Professor Levon Khachigian, Centre for Canberra, ACT Vascular Research, The University of New South Wales, Sydney, NSW (ASMR President Elect) Dr George Morstyn, The , Melbourne, VIC Mr Andrew Podger AO, Canberra, ACT Professor Jonathon Stone, Research School of Professor John Rose, Director, Air New Zealand, Biological Sciences, ANU, Canberra, ACT Australian United Investment Company, Ian Potter Professor Brandon Wainwright, University of Foundation, Melbourne, VIC Queensland, Brisbane, QLD Mr David Vos, Inspector General of Taxation, Sydney, NSW Dr Cameron Webber, Canberra, ACT

The John Curtin School of Medical Research Annual Review 2005

8 Research Programs Division of Immunology and Genetics Predictive Medicine Group

Head of Division

Research Programs Research Professor Christopher Parish

How Genetic Variations Affect Mental Health Professor Bob Simon Blanden Easteal Division of Immunology and Genetics

The Division of Immunology and Genetics is made up of research groups and Groups and Laboratories Our research is concerned with The Predictive Medicine Group’s research The study is unique in several aspects: how differences in people’s focuses on how genetic variations laboratories researching cellular, molecular and genetic processes relevant • Three adult age groups are involved. £ Cancer and Human genomes affect their mental between individual people infl uence their to medicine. Immunology Group health and related aspects of mental health and related aspects of their • Sample sizes are large – over 2000 people Common medical problems investigated in the Division include: infectious £ Cancer and Vascular behaviour, personality and behaviour, their personalities, and the from each of the three age groups are involved. diseases, cancer, diabetes, autoimmune disease and mental illness, with a Biology Group ageing. Our aim is to develop way they change during adult life. We ways of using this information to also develop methods for translating this • Each group is sampled from the general major interest being the immune system . Researchers in the Division carry £ Computational Genomics help people improve the quality information into services that enable people population rather than from patients out research into viral replication, analyses of the immune response to viral Group of their lives. to improve their health and wellbeing and suffering from a particular disorder. This infection, and development of HIV and cancer . Members also study £ Diabetes/Transplantation enhance their quality of life. gives a broad sample to study many different http://jcsmr.anu.edu.au/org/dig/ molecular and physiological aspects of autoimmunity and its contribution Immunobiology Laboratory aspects of health in the same group of predictivemed/index.php Working closely with the Centre for Mental to the pathogenesis of diseases such as diabetes and multiple sclerosis, and people. It also avoids bias issues that can £ Immunogenomics Laboratory Health Research ANU, the Predictive compromise clinically-based studies. investigate the processes of infl ammation, blood vessel growth and spread Medicine Group has participated in their £ Immunopathology Group of tumours. PATH through life project. This project has • Each group is followed through time £ Infection and Immunity Group followed three groups of people, in their and revisited periodically giving us a The research carried out within the Division and its associated programs has 20s, 40s and 60s, sampled from the Canberra longitudinal profi le of health, lifestyle been enhanced by the establishment of the Australian Phenomics Facility as £ Predictive Medicine Group community. As the project continues we and environmental exposure. a major national research facility. The mutant mice generated in the Facility £ Vaccine Immunology Group will investigate how different forms of Our work is greatly facilitated by the human will provide a range of animal models for the study of the many biological particular genes, important for normal genome and related projects, which allow us £ Viral Immunology & Molecular brain function, affect people’s psychological processes under investigation by groups within the JCSMR. to study specifi c groups of genes much more Group makeup at different life stages, in the comprehensively than has been possible in The pursuit of long term basic science goals is balanced by attempts to context of different life events, and against the past. The analysis is starting to yield a translate fundamental discoveries into clinical applications. These include the background of different social and other number of interesting results, particularly environmental conditions. the possible application of negatively-charged sugar molecules as novel in the area of social behaviour. Our goal is to generate knowledge that can be used to anti-infl ammatory or anti-cancer drugs and naked DNA and recombinant The causes of mental illness are complex. predict future mental health profi les. n poxviruses as vaccines for the prevention of certain infectious diseases. n Genes are involved, but they do not operate in isolation from other factors. The PATH study is designed to enable us to tease out contributions of different kinds of factors, genetic, developmental, social and environmental, and to understand the interplay between them.

10 11 Matrix Biology Laboratory-Cancer and Vascular Biology Infection and Immunity Group Research Programs Research Programs Research

Sugars that Change Cell Behaviour Understanding Virus-host Interaction Dr Craig Freeman Division of Immunology and Genetics Dr Guna Karupiah Division of Immunology and Genetics

By understanding the way cells On the surface of all cells and in the enzyme acts to break down the heparan The fi ndings made by the One important focus of our group has been immune parameters results in the control interact with their environment surrounding matrix there are a number of sulfate in the matrix, allowing the cells Infection and Immunity group to use poxviruses as a tool to understand the of and recovery from a generalized primary we can develop drugs to modify different carbohydrate molecules, several of to pass through it. The Matrix Group was have implications worldwide for workings of the immune system. Ectromelia poxvirus infection. the way a cell behaves in both which are highly negatively charged anionic one of the fi rst to develop a simple test to the understanding of antiviral virus (ECTV), a poxvirus closely related to Another aspect of the ongoing work in the health and disease. With this polysaccharides or glycosaminoglycans measure heparanase activity and to purify immunity, and development of vaccinia and variola viruses, is a natural group relates to investigating the interaction information we aim to prevent (gags) such as the family of heparan sulfates and characterise its activity. This led to both vaccine strategies. mouse pathogen that has coevolved with of specifi c virus-encoded host response cancer growth and spread, and and chondroitin sulfates. These play a the subsequent cloning of the enzyme, and its host and causes a generalized infection http://jcsmr.anu.edu.au/org/dig/infi mm/ modifi ers with the host immune system. help cure autoimmune diseases, vital role in many biological processes, the development of a novel carbohydrate termed mousepox. This model has been index.php Using a combination of gene knockout diabetes and viral infections. including cell growth and development, drug, PI-88, a potent inhibitor of heparanase used extensively to study pathogenesis mice and mutant viruses, we are studying allowing attachment of cells together or activity and growth factor interaction with of generalized viral infections, genetic http://jcsmr.anu.edu.au/org/dig/ how some specifi c virus-encoded molecules to the surrounding matrix and allowing heparan sulfate. PI-88 is now in clinical trials resistance to disease and the immune canc-vascbiol/matrixbiol/index.php infl uence/subvert the host immune the entry of viruses and other pathogens as an anti-cancer drug. response to virus infection. It is also response. We are currently in the process into cells. Many biologically important considered a good model for understanding We have more recently developed a new of determining the effect of deletion of a proteins, enzymes and growth factors bind the pathogenesis of smallpox, a disease series of compounds, several of which particular viral protein on the host antiviral to cell surface and matrix gags which can caused by variola virus in humans. We exhibit selective inhibitory activity against response and virus control. then regulate their physiological actions have recently shown a correlation between heparanase activity and the binding of by allowing their storage close to their site immune response and resistance to disease, We are also interested in determining the selected growth factors and proteins to of action, by enhancing their actions, or using different strains of mice. These correlates of protective immunity against gags. Such compounds may lead to the preventing their destruction by fi ndings in the mousepox model are likely to a secondary infection and have employed development of a new series of drugs to The research interests of our group are in degradative proteinases. mirror outcomes in smallpox patients. a panel of gene knockout mice in prime- prevent cancer, infl ammation, viral infection the broad area of virus-host interactions. challenge experiments in which avirulent We are developing carbohydrate-based and antilipemic agents. n We are pursuing this goal using a range We believe that the factors determining ECTV is used to prime mice that are then drugs that prevent various proteins from of viral (e.g. pox, infl uenza A and herpes) resistance and susceptibility to disease challenged with virulent ECTV. The results binding to their specifi c target gags. This and animal models. The immune responses caused by poxvirus infection are complex. from these experiments indicate a crucial form of therapy can be used to modify that control and clear viruses often cause Indeed, we now have a large body of role for antibody in the recovery of mice various physiological and pathological immunopathology that has serious, evidence to show that the removal of a Research Highlights from secondary poxvirus infections. These processes involving protein binding to cell sometimes lethal, consequences for the single immune parameter may be able fi ndings have important implications surface and matrix gags. This binding occurs £ the anti-cancer drug PI-88 host. These studies are being carried out to to reverse resistance to disease, however for antiviral immunity and vaccination during cancer growth and spread, new developed in the Cancer and determine the immunological parameters our data challenges the view that a single strategies and have generated worldwide blood vessel formation (which can stimulate Vascular Biology Group has that allow the rapid resolution of virus parameter can reverse susceptibility to interest in studying antibody responses to cancer growth), infl ammation and the entry recently been approved for a infection, in parallel with others that disease. For example, our recent results poxvirus infections, as there is a and spread of pathogens such as viruses into phase III against reveal the many strategies that viruses demonstrate a critical, and previously re-emergence of interest in determining the cells. It is also involved in the regulation of cancer have evolved to subvert the host immune unrecognized, role for B cells and antibody immune parameters necessary for protection lipid metabolism and blood clotting. response. It is our belief that understanding that can now be added to the list of immune £ PI-88 and related compounds against smallpox in humans. n virus-host interactions is the most promising parameters required for recovery from To move out of the bloodstream and are being investigated as route to the development of effective ECTV infection. Distilling the data that the through the surrounding matrix, many antiviral (herpes and dengue vaccines and of selective treatments that group has generated over many years, it cells, including malignant cancer cells and fever) and anti-malarial drugs. would minimize the damaging effects of an has become apparent that the temporally cells involved in infl ammation contain high They may also inhibit the established infection. coordinated action of a large number of levels of an enzyme called heparanase. This kidney disease albuminuria

12 13 14 Research Programs molecular.php http://jcsmr.anu.edu.au/org/dig/vi-mv/ disease intheimmunisedhost. have lost the ability to produce live attenuatedflavivirus vaccines Our research explainsinpartwhy Understanding Viral Virulence Molecular Virology Laboratory Dr MarioLobigs with sulfatedsugars whichare present involves theinteraction oftheflaviviruses This mechanismforvirulenceattenuation of theattenuatedvirusesincell culture. adversely affectthereplication properties virulence inanimalhostsbutdoesnot to theseviruseswhichdestroys their We haveuncovered amechanismcommon diseases inhumans. most importantmosquito-transmitted viral Nile virus)whichare responsible forthe and Murray Valley encephalitis andWest flaviviruses (yellow fever, dengue,Japanese Our research isfocusedonanumberof application oflivevirusesforvaccination. attenuation) isanessentialbasicstepinthe viruses. Reducingviral virulence(virulence manipulating thepathogenicpotentialof virus strains. Second,itformsthebasisfor will befollowinginfectionwithdifferent will progress, andwhatthelikelyoutcome First, itwillallowustopredict howadisease The significance ofthisresearch istwo-fold. infection ofthehost. mechanisms foraltered virulenceduring at themolecularlevelanddefining in identifyingviral virulencedeterminants Laboratory hasalong-standinginterest to hostimmunity. TheMolecularVirology replication rate, tropism andsusceptibility virulence determinantswhichinclude age, immunestatusandhealth,viral of aninterplayhostfactors, suchas produce diseaseinitshost.Itistheresult Virulence isthecapacityofavirusto Division ofImmunologyandGenetics for viral attachmentandentryintoahost low ormoderate affinity maybebenefi cial the virusestosulfatedsugars: whilsta is dependentonthebindingaffinity of the surfaceofvertebrate cells. Attenuation everywhere onextracellular matricesandon to spread insidethehost.Thismeansthat rapidly removed from thecirculation and fail binding affinity andasaconsequence are cell, theattenuatedvirusesdisplayahigh immensely successfullivevaccines. least inpart,fortheattenuation ofthetwo mechanistic explanationtoaccount, at provide for thefirst timeamolecularand that wehaveidentified. Accordingly, we are altered atoneof thekeydeterminants among numerous otheraminoacidchanges, binding affinity forsulfatedsugars and, and Japaneseencephalitisdisplayelevated licensed livevaccinesagainstyellowfever sulfated sugars. Interestingly, twocurrently protein foraugmentedbindingaffinity to key determinantsontheflaviviral surface loss ofvirulenceandhaveidentified the change wasresponsible forthedramatic found thatinmostcasesasingleaminoacid sugars andhencevirulenceattenuation.We for enhancedbindingaffinity tosulfated flaviviral surfaceprotein whichaccount We havemappedthemutationsin the brain). disease (e.g.encephalitisifthevirusenters could causeapotentiallylifethreatening fail toreach target organs where infection to establishaninfectioninthehost,itwill although theattenuatedvirusmaybeable n

15 Research Programs contributions, bothscientific andsocial,willbewarmlyremembered. farewell toourfriend andcolleagueProfessor Peter Gage.Peter’s many During 2005,members oftheDivisionMolecular Biosciencebidasad Chemists heldinCapeTown, SouthAfrica. at theconference oftheWorld Association ofTheoretically Oriented scientific contributions.Professor JillGready wasaplenaryspeaker Researchers intheDivisioncontinueto be acknowledgedfortheir Elucidationofthemechanismtranscription factorc-Relfunction • TheDulhuntygroup hasdiscovered functionaldifferences between • TheAllergy andInflammation Research Group hasshownthatthe • Usingthree dimensionalimagingtechnology, theTremethick laboratory • Some ofthehighlightsfrom thisyearinclude: disease states,includingcancer, priondisease,asthmaandallergy. expression. Disruptionoftheseprocesses formsthebasisofmany structure andfunction,signaltransduction andgenomefunction environment interactions, cell:cellcommunication,membrane protein The research ofindividualgroups spansmanyareas includingcell: how normal cells function, to better understand abnormal cell behaviour. Researchers intheDivisionofMolecularBioscienceaimtounderstand Division ofMolecularBioscience Professor Frances Shannon Head ofDivision inflammatory andallergic diseaseas wellascancer. in TcellsbytheShannonlabhasimplicationsforrole ofc-Relin contribute tocontractile dysfunctioninmyotonicdystrophy. different formsofareceptor inmusclecells,theryanodinereceptor, that interleukin IL-13inducedbronchospasm inasthma. enzyme Arginase 1playsanimportantrole intheregulation of organisation ofthecentromere. of thespecialisedscaffoldingwhichsupportsthree-dimensional by discoveringtherole ofaparticularprotein variantintheassembly region ofthechromosome involvedincelldivision(thecentromere), has gainednewinsightsintothestructure ofthespecialised,constricted n £ £ £ £ £ £ £ £ £ £ £ £ Groups andLaboratories MuscleResearch Group Membrane Physiologyand GeneTargeting Laboratory CytokineMolecular Biology CytokineGeneExpression ComputationalProteomics and Chromatin andTranscriptional BiomolecularStructure Autoimmunityand andInflammation Ubiquitin Laboratory Molecular GeneticsGroup Biophysics Laboratory and SignallingGroup Laboratory Therapy DesignGroup Regulation Laboratory Laboratory Genetics Laboratory Research Group

15 Research Programs Research Molecular Genetics Group Gene Targeting Laboratory Research Programs Research Programs Research

Towards Personalized Medicine Gene Targeting: Creating Mice with a Pre-determined Genetic Makeup Professor Philip Board Division of Molecular Bioscience Associate Professor Klaus Matthaei Division of Molecular Bioscience

Variation in an individual’s There is considerable genetic variation in bacteria and then determine their Our aim is to generate A major aim of modern biology is to way animals can be generated that are capacity to metabolize foreign between individuals that determines reactivity with different chemicals. We also genetically modifi ed understand how genes function. In identical to the original mouse strain except chemicals can result in their capacity to metabolize and respond collaborate with several crystallographers to mice to mimic human disease. particular it is important to understand that the function of a single gene has been susceptibility to diseases such as to therapeutic drugs. Some individuals determine the three-dimensional structure how genes are altered in human disease. deleted thereby allowing the study of the http://jcsmr.anu.edu.au/org/dmb/genetarget/ cancer and Parkinson’s disease. metabolize certain drugs at such a high of the enzymes so that functional changes However, it is often impossible to perform loss of this gene in vivo. Similarly, it is also index.php rate that “normal” doses are ineffective. In can be correlated with structural alterations. studies directly in humans, and easier to possible to add new genes into the ES cells http://jcsmr.anu.edu.au/org/dmb/molgen/ contrast others may metabolize drugs at Our studies have identifi ed several GST variants work with a more manipulable system like resulting in “transgenic” mice that now have index.php a slow rate and suffer higher toxicity. This that have a signifi cant impact on cancer the mouse. Since natural mutations occur overactive genes. genetic variation in drug metabolism also susceptibility or response to chemotherapy. by chance, fi nding a mutation in mice that Gene targeted and transgenic mice allow modifi es susceptibility to environmentally mimics a particular human disease is often Effects of GST defi ciency us to study the function of a cloned gene derived chemicals that can cause cancer or diffi cult. Our knowledge of the nucleotide in the context of the whole mammal by other disorders such as Parkinsons’s disease. In addition to their contribution to sequence of a gene means that it is now creating mutant mice modifi ed for specifi c Understanding this variation in individuals detoxifi cation reactions, some GSTs appear possible to produce a mouse that carries a genes. New techniques are now being will allow the personalized prescription of to play other signifi cant roles. These include desired mutation. This procedure is called developed where the gene targeted or therapeutic drugs at optimum levels and will the metabolism of endogenously derived gene targeting. transgenic genes can be turned on and off lower the chances of adverse drug reactions. compounds and the modulation of stress Gene targeting involves the use of at will, allowing complete control of gene kinases and ion channels. To study these Drugs and other foreign chemicals are recombinant DNA technology to modify a expression to closer mimic human disease. novel capacities in greater detail we have activated or detoxifi ed by a range of cloned gene (usually to stop its function). started a program to generate mice that We have generated a series of different different enzymes. In the Molecular Genetics At the same time, ES cells isolated from are defi cient in certain GSTs. This work is mouse mutants that are at different stages Group our research is focussed on a family an early mouse embryo (a blastocyst) carried out in collaboration with Dr Klaus of investigation. These include mouse models of enzymes called glutathione transferases are cultured. The modifi ed gene is then Matthaei. Glutathione transferase Zeta of asthma, gut allergy, nerve re-generation, (GSTs) that are responsible for the introduced into the ES cells such that the (GSTZ) was discovered by our bioinformatics parasite-host relationships, hypertension, detoxifi cation of a wide variety of chemicals. normal gene is replaced by the mutated analysis and is involved in the breakdown wound healing, drug de-toxifi cation, muscle gene. The modifi ed ES cells are then Identifi cation and characterization of of the amino acids phenylalanine and diseases and cancer. n micro-injected into another blastocyst, GST variants tyrosine. Mice defi cient in GSTZ suffer from and the ES cells become integrated. These In recent years we have used the rapidly liver damage when there are high levels �combination� blastocysts are re-implanted expanding DNA sequence databases of phenylalanine in their diet. Surprisingly into pseudo-pregnant mice and give rise to identify new members of the GST we recently found that these mice are very to live chimæric offspring that carry the gene family and to discover genetically sensitive to paracetamol, a commonly used modifi ed injected cells as well as the normal determined variants or “polymorphisms”. To pain killer. This suggests that humans who cells (see Figure of chimæra showing a evaluate the functional signifi cance of these are defi cient in GSTZ may be at risk of severe mouse in which white ES cells were injected polymorphisms in drug and foreign chemical liver toxicity if they consume paracetamol or into a black embryo). Since the injected metabolism we express the human enzymes other oxidizing drugs. n cells can also contribute to the testis of these mice, the breeding of a chimæra with a normal mouse gives rise to an animal carrying the genes of the modifi ed stem cell (including the mutated gene). In this

16 17 Membrane Physiology and Biophysics Laboratory Allergy and Infl ammation Research Group Research Programs Research Programs Research

Ion Channels in the Brain Genes and the Environment: A Critical Partnership in the Development of Asthma Dr Louise Tierney Division of Molecular Bioscience Dr Dianne Webb Division of Molecular Bioscience

The human brain is a very Nerve cells have the unique ability to are gradually discovering how these ion Asthma is widespread and affects Abnormal immune responses to Why is the bronchial epithelium more complex organ, containing communicate precisely and rapidly over long channels behave, giving us insight into the over two million Australians. environmental allergens such as pollens, easily damaged in asthmatics? around 1011 neurons, which physical distances throughout the brain, way in which the brain responds to the Defi ning how a Th2 type immune moulds and house dust mite particles Studies of population health have shown combine to form a myriad of spinal cord and body, both with one another incredible range of demands made of it. n response is initiated and generates underpin the development of asthma. that the gene encoding an enzyme found neuronal circuits. All of these and with target cells such as muscle and tissue abnormalities in individuals The T helper 2 (Th2) lymphocytes and in the bronchial epithelium, Glutathione share the common feature of endocrine cells. This ability derives from susceptible to the development of eosinophils that infi ltrate the lungs in Transferase (GST)Pi, is often different in inhibitory infl uence that prevents electrical signals generated by membrane asthma will not only contribute asthmatics is an unusual immune response asthmatics. We are now investigating the brain from experiencing proteins, called ion channels and receptors, Research Highlights to our basic understanding of more commonly associated with parasitic whether these changes in GSTPi weaken excitatory overload. Our group is which allow specifi c ions (Na+, K+, Ca2+ or Cl-) the processes underlying asthma infections. Factors released by these Th2 cells the way in which this molecule protects the £ through site-directed investigating this basic feature of to pass rapidly across the membrane. At the pathology, but also generate new potentiate airway damage in asthmatics by mutagenesis we have identifi ed epithelial cell against oxidative damage and neuronal signalling by studying information for better design of stimulating the secretion of mucus, growth molecular level the signalling properties not only how the fl ow of induction of the Th2 infl ammatory cascade. some of the functional and of a nerve cell derive from the complex therapeutic agents against this of cell layers around the airway wall and chloride ions is prevented in Why do asthmatics develop Th2 type structural properties of the proteins in its membrane – ion channels, the absence of GABA but, also, widespread disease. deposition of extracellular matrix, which infl ammation so readily? specifi c proteins that generate transporters and receptors for specifi c how it is transiently enabled collectively cause thickening of the airway http://jcsmr.anu.edu.au/org/dmb/allergy/ A receptor found on infl ammatory cells, these inhibitory electrical signals neurotransmitter chemicals. Our laboratory in response to the appropriate wall and loss of elasticity. Th2 factors also aigroup/webb.php IL-4R, plays a critical role in regulating Th2 in the brain. is determining how the particular ion GABA trigger stimulate the smooth muscle band around responses and we have shown that discrete channels that conduct Cl- ions in response the airways so that contraction is more http://jcsmr.anu.edu.au/org/dmb/membrane/ £ we have demonstrated that easily triggered. Ultimately, these processes changes, similar to those found in some to the neurotransmitter γ-aminobutyric the neurotransmitter-binding index.php asthmatics, in the extracellular domain of acid work at the molecular level. These domain of these particular result in occlusion of the airways, wheezing this receptor, enhances the biasing Th2 inhibitory ligand-gated ion channels are the ion channels is capable of and breathing diffi culties. An important lymphocytes. Our studies also suggest that target of a plethora of drugs that includes independent assembly and observation in asthmatics is that the IL-4R is important in modulating the way those prescribed for mood disorders such as function, leading the way to epithelium lining the respiratory tract of in which the immune system “sees” and is anxiety, depression and insomnia, those used structural and biochemical asthmatics is more susceptible to oxidative studies of these domains in activated by allergens. for general anaesthesia in surgery and those damage, which in turn allows access of the absence of the ion pore allergens to underlying cells that initiate which are affected by many social drugs, the How do molecules released by Th2 that lies embedded in the infl ammation and the secretion of factors best known being alcohol. Recently, genetic infl ammatory cells induce lung cell membrane that enhance recruitment and activation of defects in these γ-aminobutyric acid type Representation of the airways in the normal lung damage? £ we have shown that GABA Representationand in asthma of the airways in the normal lung and in asthmainfl ammatory cells. Therefore, the hub of the A receptors (GABAA) have been associated A We have used a proteomics approach to receptors in the membrane asthma paradigm seems to revolve around specifi cally with some forms of epilepsy. identify the expression of novel proteins do not necessarily act an axis of enhanced susceptibility of the that may act as intermediaries between the independently. By acting respiratory epithelium to oxidative damage Using specialized electrodes we are able Th2 immune response and tissue damage. in concert they are able to and subsequent infl ammation, and a to record the electrical activity of a single One of these molecules, Ym2, is a lectin that exert greater infl uence upon genetic proclivity of the pulmonary immune ion channel. By applying specifi c drugs, appears to modulate cell function by binding responses to various stimuli response to a Th2 bias. selectively expressing different proteins in the brain and, thus, they to carbohydrate molecules on the surface of which interact with the ion channels enhance the response Our studies are aimed at understanding cells. We are also investigating an exciting and making mutations in the genes, we to drugs the complexities of asthma, by addressing the new asthma-related protein that appears following important questions concerning to protect the airway smooth muscle Permission from ProfessorPermission Jeffery from Prof. Jefferyprocesses that are activated in the against enhanced contractility during the NormalNormal airway AsthmaticAsthmatic airwayairway asthmatic lung. development of allergy. n 18 19 Division of Neuroscience Cerebral Cortex Laboratory Research Programs

Head of Division

Research Programs Research Professor Caryl Hill

Making Sense of Smell DrProfessor John BekkersBob Blanden Division of Neuroscience

Research within the Division of Neuroscience focuses on the function of the Groups and Laboratories As part of an effort to How does the brain work? This is one of the these neurons connect with each other brain, and how it interfaces with our bodies. Laboratories in the Division are understand the mammalian most challenging questions in science and a to generate what might loosely be called £ Autonomic Neuroeffector brain, we are studying one of its preoccupation of philosophers for millennia. a thought process. What we need is a involved in understanding how we see, hear, touch and smell, and the control Transmission Laboratory simplest and most primitive parts, Apart from the intrinsic fascination of relatively simple piece of brain in which we of the gastrointestinal tract and blood vessels. These studies are relevant to £ Blood Vessel Laboratory the olfactory cortex, which is “knowing oneself” at the most fundamental can study assemblies of neurons performing human diseases, such as epilepsy, Alzheimer’s Disease, hearing and visual responsible for recognising and level, an understanding of the brain will measurable tasks. The Cerebral Cortex disorders, dementia, hypertension, and gastrointestinal disorders. £ Brain Modelling Laboratory remembering odours. pay enormous dividends for human health. Laboratory works on such a system, the A litany of debilitating disorders of the olfactory cortex of the mouse brain. Research in the Cerebral Cortex Laboratory (Bekkers) has provided new £ Cerebral Cortex Laboratory http://jcsmr.anu.edu.au/org/dns/cortex nervous system – schizophrenia, Parkinson’s, insights into the workings of the olfactory cortex, the part of the brain /index.php When an animal sniffs, odour molecules £ Developmental Neurobiology Alzheimer’s, depression, epilepsy – infl ict involved in recognising and remembering odours. bind to receptors in the nose, generating a Laboratory great social and personal damage, yet fl urry of electrical signals that pass along The Developmental Neurobiology Laboratory (Hendry) has been investigating medicine currently offers little more than £ Movement and Memory nerves into the brain. The olfactory cortex how particular signaling proteins are taken up into nerve fi bres and transported Laboratory band-aid treatments. is involved in decoding these signals into back to the cell body to signal changes occurring in the target tissue. £ Neuronal Network Laboratory Why has modern science been so slow to recognisable odours. The mammalian Research in the Blood Vessel Laboratory (Hill) has demonstrated that the cell understand the brain and its diseases, and to olfactory cortex is a comparatively primitive £ Neuronal Signalling Laboratory layers of the heart wall are electrically and chemically coupled via porous gap come up with comprehensive treatments? and simple structure. By measuring its First, it must be noted that the complexity response to known odours, we hope that this junctions, and how this coupling changes in hypertension and diabetes. £ Synapse and Hearing Laboratory of the brain is astounding. We lack even relatively simple region of the brain will yield The Neuroeffector Transmission Laboratory (Hirst) has discovered that there a basic theory about how thoughts are clues about mental processing in general. are particular cells, the interstitial cells of Cajal, that control the rhythmical £ Visual Neuroscience Laboratory represented, or coded, in the brain. Yet We have studied the electrical signalling much progress has been made. In particular, contractions of the stomach, which is an important part of gastric motility. performed by two major classes of neurons we know a great deal about the building Scientists in the Visual Neuroscience Laboratory (Lamb) have found that day in the olfactory cortex (see fi gure). By blocks of the brain – the nerve cells (or vision receptors in the retina recover their electrical activity tens of thousands making electrical and optical recordings neurons) that are somewhat akin to the from thin slices of living tissue in a dish, we of times faster than night vision receptors, following adaptation to light. transistors in a digital computer. What have found striking differences between The Movement and Memory Laboratory (Redman) has been investigating we lack is a clear understanding of how these two cell types. Our work has allowed long-term changes in the strength of synaptic signals between neurons, and us to make predictions about the likely roles how these changes are related to different sources of calcium inside the of these neurons in olfactory processing. target neurons. The next step is to test our predictions by making recordings from these neurons in The Neural Network Laboratory (Stricker) has been investigating the short a mouse as it sniffs an odour. This should term dynamic changes that occur in synaptic strength between neurons, bring us closer to understanding how the and how these changes infl uence information fl ow in networks of brain makes sense of smell. n interconnected neurons. The Synapse and Hearing Laboratory (Walmsley) has discovered signifi cant differences in the properties of synapses and neurons in the brain following congenital deafness. n

20 21 Visual Neuroscience Laboratory Neuronal Network Laboratory Research Programs Research Programs Research

The First Steps in Vision What Determines Flow of Information in Neuronal Networks? Professor Trevor Lamb Division of Neuroscience Associate Professor Christian Stricker Division of Neuroscience

Vision under very low light The human eye is able to operate with the bipolar cells, and the time-course of Understanding how The most amazing feature of our brain Since synapses are strategically located in levels is mediated by the enormous sensitivity under extremely recovery, are remarkably similar to what is information fl ows between is its ability to process large amounts of neuronal circuits and their state can be rod photoreceptor system. low levels of illumination. It is able to measured in the overall visual system. So nerve cells is paramount for the information almost instantaneously and exquisitely modifi ed according to previous Recordings of electrical responses do this because its sensory cells (the rod this is one aspect of overall human visual understanding of normal brain with minimal energy expenditure; for history, the Neuronal Network Laboratory from individual rod cells and photoreceptors) are able to respond reliably performance that appears to be set at a very function and disease states, such example, we can react to a previously concentrates on elucidating both the static signals from the living human eye to the arrival of individual photons of light, early stage in the visual pathway. as Alzheimer’s disease. seen face in about a tenth of a second. structure of microcircuits and their synaptic help us to understand the fi rst and because a special neural pathway exists This involves detection at the retina, fl ow dynamics. Our investigations are based on We have also measured the speed of http://jcsmr.anu.edu.au/org/dns/ steps in vision. in the retina to convey these single-photon of information to the brain, subsequent the electrophysiological characterization of recovery of the cone pathway (that neuronetwork/index.php responses to the brain. analysis, association, decision making and communication between identifi ed cell pairs. http://jcsmr.anu.edu.au/org/dns/ operates at higher light levels) when intense motor output. For this to occur information We employ high-resolution reconstruction visual/index.php In the Visual Neuroscience Laboratory we illumination is extinguished. Our results fl ow must be rapid and unambiguous, and techniques to reveal the underlying are investigating the transmission of rod show that human cone photoreceptors large-scale parallel processing must take connectivity, specifi c pharmacological signals through the retina in the living recover their electrical response (their place. How the brain achieves these feats is tools to block the elements that modulate human eye. A very fi ne conductive fi bre is circulating current) within one-tenth of one of the biggest questions in neuroscience. synaptic dynamics, and simulation placed under the lower eyelid, and is used a second after extinction of very intense techniques to appreciate information fl ow. n to measure the electrical response of the steady illumination. Quite remarkably, this The cortex of mammals is partitioned into eye, the so-called electroretinogram, or recovery is some 50,000 times faster than distinct regions that specialise in defi ned ERG. By presenting diffuse visual stimuli is measured in our rod photoreceptors functions like sensation, motor output over very large angles of view (using a fancy following extinction of the same light - our and associative processes. The underlying Research Highlights instrument called a ‘ganzfeld’), we are able rods take some 20 mins to recovery fully. cellular structure is common to all of these £ functional identifi cation of to extract signals that arise from different This fi nding has important implications for regions yet they perform vastly different presynaptic calcium stores in levels of the retina. In particular, we can an understanding of the differences in the tasks: cortex is modularised into so-called rat and mouse cortex separate out responses arising from the biochemical mechanisms utilized by our microcircuits. It is thought that cortical fi rst two stages: the photoreceptors and the rods and cones, and for explaining how their specialisation is made possible by regional £ elucidation of the way in retinal bipolar cells. Our interest has been in mechanisms are tailored to the different variations in the static and dynamic which evoked transmitter the adaptational changes that occur in rod roles that they play in vision. n properties within these microcircuits allowing release is modulated by bipolar cells, either when the eye is exposed fast fl ow and re-routing of information. calcium stores to background illumination of moderate Research Highlights The processing abilities are dependent on £ discovery of a new form of intensity (light adaptation), or when it the largely static connectivity as well as synaptic dynamics in which is recovering following the cessation of £ the slowness of dark the dynamic properties of the individual depression and its recovery exposure to very intense illumination adaptation in overall human cells and their subcellular elements. These show unorthodox features (dark adaptation). vision is present at the level include synapses, which are the points of of rod bipolar cells in £ clarifi cation of how We have found that the behaviour of rod information exchange between cells, and the retina calcium stores modulate bipolar cells under both conditions is very dendrites, the processes that listen and react synaptic dynamics similar, so that during dark adaptation after £ our cone photoreceptors to the talk by synapses. As with the human intense exposures, the bipolar cells act as recover from intense genome project, the static and dynamic £ assesment of the role these if they are experiencing a background light illumination some 50,000 elements of these circuits need to be forms of synaptic dynamics that is slowly fading away. Furthermore, times faster than our identifi ed and their properties explored. play in information transfer we fi nd that the changes in sensitivity in rods do

22 23 The Synapse and Hearing Laboratory Research Programs Research

What Changes Occur in the Brain Following Deafness? Professor Bruce Walmsley Division of Neuroscience Staff & Student Achievements Degrees, Prizes & Awards Cochlea-related deafness causes An important aspect of the auditory normal generation of a single, or only a few, signifi cant changes to occur in system is the existence of tonotopic nerve impulses. Detailed pharmacological, auditory centers of the brain. maps. The cochlea is arranged with electrophysiological and immunolabelling The John Curtin School of Medical Research enjoys an Finding and understanding these the basal hair cells responding to experiments have shown that this increased exceptional reputation for the quality of training available changes helps us to understand highest sound frequencies, and the excitability is due to a down-regulation of to young scientists. Our researchers take a leadership role the auditory system, and apical hair cells responding best to low low-threshold potassium channels in the in the supervision and mentoring of postgraduate students allows the continued frequencies. This spatial arrangement is cells of deaf mice. Our results have also undertaking studies to complete Honours, Masters and PhD development of cochlear maintained centrally, and most of the demonstrated that a gradient of expression degree programs. implants to overcome deafness. brainstem auditory nuclei are organized of a variety of voltage-activated channels, topographically according to their best including low- and high-voltage activated Throughout 2005, JCSMR Staff and students have accepted http://jcsmr.anu.edu.au/org/dns/synapse/ response to acoustic frequencies potassium channels and hyperpolarization- many prestigious prizes, honours and awards. This recognition index.php (ie. tonotopically). activated channels, forms the basis of acknowledges the dedication they bring to their research. the tonotopic gradient in cell fi ring Hearing is a highly developed sense, requiring Congenital deafness properties in the MNTB. This gradient is extremely rapid and complex processing It is generally assumed that sensory completely disrupted in the deaf mice. of signals transmitted to the brain via input to the developing brain shapes the Our results demonstrate that spontaneous the auditory nerve. Connections between strength of synaptic connections and the auditory nerve activity is necessary for auditory neurons involved in the localization membrane properties of neurons. Insight the formation of tonotopic gradients in of sounds form some of the most powerful into the role of activity in regulating normal development. In addition, the and fastest synapses in the mammalian synaptic transmission and neuronal observation that synaptic and neuronal brain. In the Synapse and Hearing Laboratory membrane properties can be gained fi ring properties are different in congenital we study the central processing of auditory by studying the effects of eliminating deafness is important to our understanding information at the most fundamental level. or reducing auditory nerve activity (i.e. of how signals are processed in the central deafness). We are studying a naturally pathways following artifi cial stimulation Auditory pathways in the mammalian occurring strain of mice which are deaf of the auditory nerve, as occurs in cochlear brainstem from birth. These mice do not exhibit implants. n Sound entering the ear stimulates hair cells spontaneous auditory nerve activity in the cochlea. Hair cells make synaptic during development. Our experiments connection via special ribbon synapses with have shown that the synapse between spiral ganglion cells, which in turn give auditory nerve fi bers and neurons in Research Highlights rise to the primary auditory nerve fi bers the brainstem is much stronger in £ surprisingly, the loss of carrying auditory information to the brain. deaf mice, due to disrupted calcium auditory nerve activity in Under normal circumstances, the ribbon buffering in the presynaptic terminals congenital deafness leads synapses continually release chemical of the auditory nerve fi bers. We have to a strengthening of some neurotransmitter, even in the absence of also shown that the postsynaptic nerve cell connections sound stimulation. This transmitter release neurons in a major brainstem nucleus, results in the generation of spontaneous the medial nucleus of the trapezoid £ the establishment of nerve impulses in the auditory nerves. body (MNTB), are much more excitable tonotopic maps, which Spontaneous activity occurs before the than in normal hearing mice. These form the basis for auditory The John Curtin School of Medical Research opening of the ear canal and the onset of cells respond to inputs by generating processing, is disrupted in Annual Review 2005 airborne sound-generated responses. many nerve impulses, in contrast to the congenital deafness 24 Degrees 2005 Prizes and Awards 2005 Awards 2005

Congratulations to our students who Prizes and awards presented have successfully completed their to JCSMR staff and students post-graduate study during 2005. during 2005. Degrees 2005 Degrees

Degrees Prizes and Awards

PhD degrees awarded in 2005 Masters degree awarded in 2005 Arsov T 2005 Ruth Gani Memorial Travelling Fellowship for Human Genetics Alsharifi M Bowman E Immunobiology of an alphavirus infection in mice Spatial variation in the photopic multifocal electroretinogram Bunting K Barlow VP Student poster prize: Lorne Genome Conference, Lorne, VIC Generation of immunological diversity and amplification of the humoral immune response Graduate diplomas awarded 2005 Chen X through alternative mechanisms Cowan A I Award for excellence: non-government-funded Chinese Student overseas Jusse J Graduate Certificate in Higher Education (ANU) Roles of lipid rafts and cytoskeleton in B cell antigen Holgate J Ellyard J receptor signalling Graduate Diploma in Neuroscience Student poster prize: Lorne Cancer Conference, Lorne, VIC Leao R Professor Frank Fenner presents The Fenner Medal Synapses and neurones in central auditory pathways Honours degrees awarded in 2005 Goodnow C to Dr Alison Jones of congenitally deaf mice Brew JM 2005 Commonwealth Health Minister’s Award for Excellence in Health and Medical Research Licon Luna RM Hinton RA On the role of cell-mediated cytotoxicity in a mouse model of flavivirus encephalitis Hynes KE Harrison J Liston A Kim J-H International Scholarship to attend the AIDS Vaccine 2005 Conference, Montreal, Canada Genetic lesions in thymus-acquired self tolerance Kuo I Premzl M Lim C Hyun M Prion protein gene and its shadow Lindsay H NIB Travel Award to attend Protein Society Meeting, Boston, USA Sharkhuu T Mechanisms predisposing the development of allergic Linterman MA Jones A airways disease Manker A Frank Fenner Medal: Most outstanding PhD thesis submitted in the JCSMR during 2004 Walker E Pang M Investigating modifier genes in hereditary haemochromatosis Scott PC Liston A Zelensky AN Siggs OM Australian Society for Medical Research New Investigator Award: The Canberra Hospital Annual Scientific Meeting, Canberra, ACT In silico, analysis of C-type lectin domains’ structure Sutherland D and properties Thomas AJ Morris M Australia and New Zealand Society for Cell and Developmental Biology Walker AA Portland Press Poster Prize, ComBio2005, Adelaide, SA

Navarro-Gonzales M Best Student Oral Presentation: 2005 Neuroscience Colloquium, Kioloa, NSW Best Student Oral Presentation: 2005 Australian Physiological Society Annual Meeting, Canberra, ACT

Papathanasiou P Catcheside Prize: The Genetics Society of Australia Professor Ian Frazer, recipient of The Curtin Medal

26 27 Awards 2005 Awards

Prizes and Awards

Parish C The 2005 Clive and Vera Ramaciotti Medal for Excellence in Biomedical Science Research Collaborations

Ranasinghe C & Visitors to JCSMR Travel Grant to attend the AIDS Vaccine 2005 Conference, Montreal, Canada

Regner M Staff and students of The John Curtin School of Medical Australian Academy of Science Travel Award for scientific visits to Europe Research continue to enjoy close collaborative ties with other members of The Australian National University. They also Scott PC enjoy continued scientific associations with colleagues both ANU University Medal for Honours degree nationally and internationally. Examples of these are listed in Thesis Title: Information Transfer at Dynamic Synapses: Effects of Short-Term Plasticity the following pages.

Singhal, S Australian Society for Biochemistry and Molecular Biology Poster Prize, ComBio2005, Adelaide, SA Poster Prize, Bringing Bioscience Together, ANU, Canberra, ACT

Whitworth JA (honoris causa), The University of New South Wales, Sydney, NSW

Young I 2005 Lemberg Medal: The Australian Society for Biochemistry and Molecular Biology

Yu D Australasian Society for Immunology grant-in aid to attend the 3rd Congress of the Federation of Immunology Societies of Asia-Oceania (FIMSA), Hangzhou, China

Ziolkowski A Juvenile Diabetes Research Foundation travel grant from the to attend the 8th Meeting of the Immunology of Diabetes Society, Awaji Island, Japan

Professor Christoher Parish at the award of The John Curtin School of Medical Research the 2005 Clive and Vera Ramaciotti Medal Annual Review 2005 for Excellence in Biomedical Science 28 2005 Collaborations Research Collaborations 2005 2005 Collaborations Research Collaborations

Baker Dr RT Function of Zeta class GSTs Role of triadin and calsequestrin in regulating Identifying genes that modify athletic performance Zinc fingers in deubiquitylating enzymes Professor MW Anders Department of calcium release from intracellular stores and Professor K North Neurogenetics Research Unit, The Dr J Mackay School of Molecular and Microbial Pharmacology and Physiology, University of Contribution of splicing defects in ryanodine Children’s Hospital at Westmead, Westmead, NSW Rochester Medical Centre, Rochester, USA receptors to myotonic dystrophy Biosciences, The , Sydney, NSW Freeman Dr C Proteins that associate with the proteasome Studies of GST knock out mice Professor R Dirksen Department of Pharmacology Role of heparanase in the pathogenesis of Professor J Mayer School of Biomedical Sciences, Dr J Dahlstrom Department of Anatomical and Physiology, Medical proteinuria University of Nottingham Medical School, Pathology, The Canberra Hospital, Canberra, ACT Centre, Rochester, USA Professor D Power and Dr V Levidiotis Austin Nottingham, UK Regulatory and pore forming domains of calcium Casarotto Dr MG Hospital, Melbourne, VIC Deubiquitylating enzymes release channels Structural studies into the mechanism of Role of heparanase in the pathogenesis of diabetes Dr S Wood Child Health Research Institute, Professor F Zorzato Department of Experimental dihydrofolate reductase Dr V Levidiotis Austin Hospital, Melbourne, VIC Adelaide, SA and Diagnostic Medicine, General Pathology section, Professor G Roberts Centre for Mechanisms of University of Ferrara Medical School, Ferrara, Italy Role of heparanase in the ovary Bekkers Dr JM Human Toxicity, University of Leicester, Leicester, UK Actions of CLIC and GST family proteins on the Dr R Rodgers Obstetrics and Gynaecology, The Neurophysiology of a Galanin receptor knockout Dr J Basran Department of Biochemistry, University heart , Adelaide, SA mouse with an epileptic phenotype of Leicester, Leicester, UK Dr M Diaz School of Veterinary Studies, The Heparanase as an anti-tumour target Dr A Jacoby, Dr T Iismaa and Professor J Shine Chitinase and chitin binding proteins , Edinburgh, UK Dr N Pavlakis Royal North Shore Hospital, The Garvan Institute of Medical Research, Sydney, Dr C Vorgias Biology Department, Athens University, Role of the Beta subunit of the dihydropyridine Sydney, NSW NSW Athens, Greece receptor in excitation-contraction coupling Role of heparanase in the pathogenesis of diabetic Influence of the dendritic tree on the firing Peptide activators of the ryanodine receptor Professor R Coronado Department of Physiology, retinopathy properties of neurons Professor I Toth Pharmacy Department, University University of Wisconsin, USA Dr J Hu Zhongshan University, Guangzhou, China of Queensland, Brisbane, QLD Professor M Häusser Wolfson Institute for Electron donor/acceptor properties of activators Goodnow Professor C Biomedical Research, University College, London, UK Effects of drugs that block Vpu ion channels and inhibitors of ryanodine receptor calcium Mechanisms regulating islet beta cells in diabetes Synaptic transmission in neuronal cultures from studied with NMR techniques release channels Dr C Nolan The Canberra Hospital, Canberra, ACT GAD67-GFP transgenic mice Professor T Watts and Dr W Fischer Biomembrane Professor J Abramson Department of Physics, Mucin gene functions Dr Y Yanagawa and Professor K Obata Gunma Structure Unit, University of Oxford, Oxford, UK Portland State University, Portland, USA Dr M McGuckin Mater Medical Research Institute, University, Japan, and RIKEN, Japan Cooper Dr P Contribution of splicing defects to myotonic Brisbane, QLD Role of Septin-3 in the synaptic vesicle cycle Adjuvant activity of gamma inulin dystrophy Dr M Cook Phenomix Aust Pty Ltd, Canberra, ACT Professor P Robinson Children’s Medical Research Professor N Petrovsky Department of Diabetes and Professor M Takahashi Department of Neurology, Institute, Sydney, NSW Endocrinology, Flinders Medical Centre, Adelaide, SA Osaka University Graduate School of Medicine, Goodnow Professor C and Bertram Dr E Bertram Dr E Professor M Korbelik British Columbia Cancer Osaka, Japan Mutations affecting male fertility Studies of the molecular nature of calsequestrin Dr M O’Bryan and Professor D de Kretser Monash Role of T cell costimulation in generation of Agency, Vancouver, Canada Professor M Varsanyi Institut für Physiologische Institute of Reproduction and Research, TCR diversity and cytokine production following Cowden Dr WB Chemie, Ruhr Universität, Bochum, Germany Melbourne, VIC influenza virus infection. The role of nitric oxide in infectious and Structure of ion channel domain peptides Mutations affecting the mammary gland Dr S Turner and Professor P Doherty Department autoimmune disease Professor N Ikemoto Boston Biomedical Research Dr C Ormandy The Garvan Institute of Medical of Microbiology and Immunology, The University of Dr K Rockett Institute of Molecular Medicine, Institute, Boston, USA Research, Sydney, NSW Melbourne, Melbourne, VIC Oxford, UK Regulation of ion channels by CRISP proteins Role of TNF members LIGHT and 4-1BBL in T cell The role of NO in regulation of EAE Dr M O’Brien and Dr G Gibbs Monash Institute of Goodnow Professor C, Bertram Dr E, costimulation Dr D Willenborg Neurosciences Research Unit, The Medical Research, Melbourne, VIC Vinuesa Dr C and Tze Dr L Professor TH Watts Department of Immunology, Canberra Hospital, Canberra, ACT Identifying genes for immunity and tolerance University of Toronto, Toronto, Canada The activity and mechanism of action of novel Easteal Professor S Dr J Cyster, Professor L Lanier and Professor A Role of STAT-1 in EAE glycoprotein processing inhibitor anti-rejection agents Genetic epidemiology of high prevalence Weiss University of California, San Francisco, USA Dr D Willenborg Neurosciences Research Unit, The Professor A Hibberd Hunter Valley Hospital mental disorders Canberra Hospital, Canberra, ACT Goodnow Professor C, Bertram Dr E and Transplant Unit, Newcastle, NSW Professor A Jorm ORYGEN Research Centre, The Whittle B Board Professor PG University of Melbourne, Melbourne, VIC Dulhunty Professor AF Genetic epidemiology of neuroanatomical Hearing mutations Determination of Glutathione transferase Various aspects of ryanodine receptor physiology correlates of high prevalence mental disorders Dr H Dahl Murdoch Children’s Research Institute, structures Dr D Laver Hunter Medical Research Institute, Professor P Sachdev School of Psychiatry, The Melbourne, VIC Professor M Parker St Vincent’s Medical Research University of Newcastle, Newcastle, NSW University of New South Wales, Sydney, NSW Institute, Melbourne, VIC Identification of novel RyR specific compounds Professor DG Lamb Department of Zoology, La Trobe University, Melbourne, VIC 30 31 2005 Collaborations 2005 Collaborations Research Collaborations Research Collaborations

Goodnow Professor C and Hoyne Dr G Hendry Professor IA Dr RK Andrews and Professor MC Berndt The Baker Modulation of the immune response by poxvirus- Role of cbl genes in B and T cell tolerance Testing behaviour of Gz knockout mice using pre Medical Research Institute, Melbourne, VIC encoded cytokine homologs Associate Professor W Langdon and Dr C Thien pulse inhibition Generation of heparanase and HRG knockout mice Professor M Buller Department of Molecular University of Western Australia, Perth, WA Dr M van den Buuse Mental Health Research Dr R Brink Centenary Institute of Cancer Medicine Microbiology and Immunology, St Louis University, Institute of Victoria, Melbourne, VIC and Cell Biology, Sydney, NSW St Louis, USA Goodnow Professor C and Liston Dr A Pupillary constriction in Gz knockout mice Heparanase expression in EAE Dr A Alcami Department of Molecular and Cellular Thymic defects in aire-deficiency Professor KW Yau Johns Hopkins University School Associate Professor D Willenborg and Dr M Biology, Centro Nacional De Biotecnologia, Professor R Boyd and D Gray Monash University, of Medicine, Baltimore, USA Staykova The Canberra Hospital, Canberra, ACT Madrid, Spain Melbourne, VIC Gz coupling to dopamine D2-like receptors in vivo Heparanase expression in hypoxia Mapping of orthopoxvirus CD8 T cell determinants Effects of Foxp3 deficiency on islet-specific tolerance Dr CD Blaha Macquarie University, Sydney, NSW Professor M Whitelaw and D Peet The University of Dr D Tscharke Queensland Institute for Medical Professor A Rudensky, Department of Immunology, Neuromuscular growth factors role of TGF-beta and Adelaide, Adelaide, SA Research, CBCRC, Brisbane, QLD University of Washington, Seattle, USA GDNF in motoneurone survival and death Dr B Roberts The University of South Australia, Dr J Yewdell and Dr J Bennink National Institutes Goodnow Professor C and Vinuesa Dr C Dr I McLennan University of Otago, NZ Adelaide, SA of Allergy and Infectious Diseases, National A programme of screening for ENU-mutations Increase of IGFBP1 following hypoxia in the Characterisation of the interaction of histidine-rich Institutes of Health, Bethesda, USA affecting lymphocyte response to antigen piglet. Protein 14-3-3 in the CSF of newborn rats glycoprotein with leukocyte Fc receptors Chemokine receptors in infectious diseases Dr R Cornall and Professor J Bell Oxford University, following hypoxia-ischaemia Professor M Hogarth and Dr B Wines Austin Dr W Kuziel Department of Molecular Genetics and Oxford, UK Dr Z Kecskes The Canberra Hospital, Canberra, ACT Research Institute, Melbourne, VIC Microbiology, Institute for Cellular and Molecular Hypoxia alters GABAA-subunit composition Migration of eosinophils in inflammatory disease Biology, The University of Texas at Austin, Austin, USA Gready Professor JE and Chakka Mr N Dr P Dodd School of Molecular and Microbial Dr S Hogan Cincinnati Children’s Hospital Medical Professor M Mack Klinikum der Universität Assessment of gene dysfunction in human Sciences, , Brisbane, QLD Centre, Cincinnati, USA Regensburg, Innere Medizin II, Abt für Nephrologie, male infertility Regensburg, Germany Professor D de Kretser and Dr M O’Bryan Monash Hill Professor CE Huttley Dr G Pathogenesis of influenza pneumonia and Institute of Reproduction and Research, Melbourne, VIC Role of the endothelium in cerebral vasomotion Multiple sequence alignment flavivirus encephalitis Dr RE Haddock University of Oxford, Oxford, UK Dr M Rezny Cray Australia Pty Ltd, Canberra, ACT Associate Professor N King Department of Gready Professor JE, Cummins Dr PL and Expression of connexins at myoendothelial gap Discovery of the properties of DNA management Physiology, The University of Sydney, Sydney, NSW Rostov Dr IV junctions in the basilar artery through studies on animal, fungal and plant genomes Dr R Foxwell Division of Health Design and Science, Application of the ONIOM QM/MM method to Dr SL Sandow Department Physiology and Dr J Cai Hong Kong University, Hong Kong The University of Canberra, Canberra, ACT simulation of enzyme reactions Pharmacology, The University of New South Wales, Software for genomic data analysis Dr T Vrevren and Dr MJ Frisch GAUSSIAN Inc, New Sydney, NSW Dr R Knight Colorado State University, Boulder, USA Lamb Professor TD Haven, USA Three-dimensional modelling of vasomotion in Adaptive modifications to BRCA1 in Transduction and adaptation in photoreceptors Professor EN Pugh Jr Department of Gready Professor JE, Hyun Mr YM and basilar arteries ancestral mammals Dr M Wakefield The Walter and Eliza Hall Institute Ophthalmology, University of Pennsylvania, Hulett Dr MD (DIG) Professor TM Griffith and Dr D Parthimos Cardiff University, Cardiff, UK of Medical Research, Melbourne, VIC Philadelphia, USA Production and specificity of CTLD protein domains Evolution of triplet repeats in mammal proteins Phototransduction in cones Dr R Alvarez Consortium for Functional Glycomics, Hirst Professor GDS Mr N Faux Monash University, Melbourne, VIC Dr S Kawamura Graduate School of Frontier University of Oklahoma, USA Properties of interstitial cells of Cajal in the Modelling spatial patterns of substitution rate Bioscience, Osaka University, Osaka, Japan, Dr M Plebanski and Dr S Xiang Austin Research gastrointestinal tract variation in mammal genomes Dr Y Fukada, Department of Biophysics and Institute, Melbourne, VIC Professor H Suzuki and Dr H Hashitani Department Dr VB Yap National University of Singapore, Singapore Biochemistry, Graduate School of Science, Japan Gready Professor JE, Vassilieva Ms T and of Physiology, Nagoya City University Medical Human electroretinogram School, Nagoya, Japan Juelich Dr T Dr OAR Mahroo Physiological Laboratory, University Chakka Mr N Properties of ion selective channels in gastric Elucidation of transcriptional mechanisms for of Cambridge, Cambridge, UK Evolution of prion protein and its homologues smooth muscle cells the establishment and maintenance of CD8 T cell Molecular mechanisms of vertebrate in vertebrates Dr N Teramoto Kyushu University, Fukuoka, Japan effector gene function in a mouse influenza A model phototransduction Dr T Simonic Department of Animal Pathology, Dr S Turner The University of Melbourne, Dr RD Hamer Smith-Kettlewell Eye Research University of Milan, Milan, Italy Hulett Dr M Melbourne, VIC Institute, San Francisco, USA Dr M Gallardo Instituto de Ecología y Evolución, Molecular mechanisms of cell invasion and Development of a scanning laser ophthalmoscope Universidad Austral de Chile, Chile Karupiah Dr G and Chaudhri Dr G angiogenesis Dr FN Reinholz and Dr BA Patterson Lions Eye Pathophysiological significance of reverse Gready Professor JE and Zelensky Dr AN Professor CN Chesterman, Professor BH Institute, Perth, WA Chong, Associate Professor PJ Hogg and Dr LM signalling through membrane TNF Structural genomics of an extracellular protein Light damage in the mouse eye Khachigian The University of New South Wales, Dr J Sedgwick Bone and Inflammation Research, domain Professor CE Remé and Dr A Wenzel Laboratory for Sydney, NSW Lilly Research Laboratories, Eli Lilly and Company, Retinal Cell Biology, University Hospital, Zurich, Switzerland Professor S Yokoyama and Dr A Tanaka RIKEN Indianapolis, USA Genomic Sciences Center, Yokohama, Japan 32 33 2005 Collaborations 2005 Collaborations Research Collaborations Research Collaborations

Lobigs Dr M Müllbacher Professor A and Regner Dr M Immunosurveillance of MCA-induced sarcomas in IL-2 gene regulation in T cells Flavivirus virulence and vaccination The mechanisms of cytolytic lymphocytes in the TH2-immune deficient mice Professor R Schwartz Laboratory of Cellular and Dr RA Hall Department of Microbiology and control of viral infections Associate Professor M Smyth Peter Macallum Molecular Immunology, National Institutes of Parasitology, The University of Queensland, Dr M Simon Max Planck Institute fur Cancer Center, Melbourne, VIC Health, Bethesda, USA Transcriptional networks in T cells Brisbane, QLD Immunbiologie, Freiburg, Germany Ramshaw Professor IA Flavivirus interferon escape The role of poxvirus encoded serpins in cytotoxic T Dr K Gardener National Cancer Institute, National Recombinant viruses expressing immune- School of Molecular and Microbial cell induced apoptosis Institutes of Health, Bethesda, USA Dr A Khromykh modulating agents Sciences, The University of Queensland, Brisbane, QLD Dr R Wallich Department of Immunology, University The role of Foxp3 in regulatory T cells Dr R Jackson Division of Wildlife and Ecology, of Heidelberg, Heidelberg, Germany Dr S Barry Department of Paediatrics, University of CSIRO, Canberra, ACT Matthaei Dr KI Adelaide, Adelaide, SA The role of IL-5 and eosinophils in allergy Parish Professor C Evaluation of HIV prophylactic and Dr Marc Rothenberg Division of Pulmonary Role of histidine-rich glycoprotein in tumour therapeutic vaccines Simeonovic Dr CJ Medicine, Allergy and Immunology, Cincinnati invasion and angiostatin formation Dr S Kent The University of Melbourne, Regulation of pig proislet xenograft destruction Childrens Hospital Medical Centre, Cincinnati, USA Dr P Hogg and Professor C Chesterman School Melbourne, VIC and assessment of the potential for xenozoonoses; The role of IL-5 in eosinophil precursor differentiation of Pathology, The University of New South Wales, Design of HIV-1 vaccines the role of anti-PERV immunity in cellular Professor J Denburg Department of Medicine, Sydney, NSW Dr D Boyle CSIRO Australian Animal Health xenograft rejection McMaster University, Hamilton, Canada Role of platelets in tumour metastasis Laboratory, Geelong, VIC Clinical Associate Professor JD Wilson Department The role of mast cells in vivo Dr M Berndt The Baker Medical Research Institute, Evaluation of new HIV-1 and hepatitis-C vaccines of Endocrinology, The Canberra Hospital, Canberra, ACT Professor S Krilis Department of Immunology, Melbourne, VIC Dr R Ffrench Westmead Hospital, Westmead, NSW Dr P McCullagh Faculty of Veterinary Science, The Allergy and Infectious Diseases, The St George Professor C Chesterman and Professor B Chong Development of vaccines against genetically University of Sydney, Camden, NSW Hospital, Kogarah, NSW School of Pathology, The University of New South modified viruses Role of matrix metalloproteinases in the Murine filariasis infections in cytokine deficient mice Wales, Sydney, NSW Professor A Ramsay LSU Health Sciences Centre, development of destructive autoimmunity and Professor A Hoerauf Faculty of Medicine, University Carbohydrate-based inhibitors of New Orleans, USA clinical diabetes in NOD mice of Bonn, Bonn, Germany leukocyte extravasation Development of a novel TB vaccine Dr R Rodgers Department of Obstetrics and Parasite infection in gene deficient mice Dr M Hickey Department of Medicine, Monash Dr W Britton Centenary Institute of Cancer Gynaecology, Adelaide University, Adelaide, SA Medicine and Cell Biology, Sydney, NSW Dr L Dent Eosinophil Biology Laboratory, University, Melbourne, VIC Stricker Associate Professor C Microbiology and Immunology, School of Development of dendritic cell targeting vaccines Evaluation of a nasopharyngeal cancer Quantal analysis of cell pairs in the subplate during Molecular and Biomedical Science, Adelaide Associate Professor D Jackson Department of therapeutic vaccine development University, Adelaide, SA Microbiology and Immunology, The University of Professor D Moss Queensland Institute of Medical Dr J Torres and Professor MJ Friedlander The role of the ryanodine receptor in vivo Melbourne, Melbourne, VIC Research, Brisbane, QLD Department of Neurobiology, University of Alabama, Department of Anesthesia, Development of a liposome-based TB vaccine Professor P Allen Ranasinghe Dr C Birmingham, USA Centenary Institute of Cancer Brigham and Womens Hospital, Harvard Medical Dr W Britton Evaluation of HIV prime boost vaccines Medicine and Cell Biology, Sydney, NSW School, Boston, USA Dr S Kent The University of Melbourne, Melbourne, VIC Stuart Dr GJ Inhibition of spontaneous tumour development Interaction of action potentials with inhibitory Müllbacher Professor A HIV vaccines and T cell immunity by PI-88 synaptic events Oral induced T cell tolerance Dr S Turner The University of Melbourne, Dr D Hanahan and Dr J Joyce University of Professor M Häusser Wolfson Institute for Elizabeth MacArthur AG Institute, NSW Melbourne, VIC Dr J Chin California, San Francisco, USA Biomedical Research, University College, London, UK Department of Agriculture, Camden, NSW Mucosal prime boost vaccines The role of granzyme A in fungal infection Parish Professor C, Freeman Dr C and Professor A Ramsay LSU Health Sciences Centre, Thomson Dr SA Dr R Ashman Oral Biology and Pathology, The Hulett Dr M New Orleans, USA Hepatitis C SAVINE University of Queensland, Brisbane, QLD 3D structure of mammalian heparanase Redman Professor SJ Dr RA Ffrench Pediatric Research Laboratories, The role of granzymes in viral infection Dr M Parker St Vincents Hospital, Melbourne, VIC Threshold excitation in dendritic neurons Sydney Children’s Hospital, Westmead, NSW Dr M Smyth Peter MacCallum Cancer Centre, Professor J Jack University College, London, UK Dr P White Prince of Wales Hospital, Sydney, NSW Melbourne, VIC Parish Professor C and Simson Dr L Professor A Lloyd Department of Infectious The granzymes in early defence against viral infection Development of a liposome-based tumor vaccine Shannon Professor MF Diseases, Prince of Wales Hospital, Sydney, NSW Dr J Trapani and V Sutton Peter MacCallum Cancer Associate Professor P Hogg School of Pathology, Control of GM-CSF gene transcription in T cells Tuberculosis SAVINE Centre, Melbourne, VIC The University of New South Wales, Sydney, NSW Dr A Holloway Discipline of Biochemistry, University Professor W Britton Centenary Institute of Cancer Gliotoxin as virulence factor in Aspergillosis Thermographic detection systems for tumor of Tasmania, Hobart, TAS Medicine and Cell Biology, Sydney, NSW Dr J Pardo and Dr M Simon Max Planck Institute establishment and growth The role of c-Rel in CD28 signaling and regulatory Nasopharyngeal carcinoma SAVINE fur Immunbiologie, Freiburg, Germany Ms P McCahon and Dr B Eckersley MIDI - Medical networks in T cells Professor D Moss and Dr R Khanna Queensland Infrared Digital Imaging, Canberra, ACT Dr S Gerondakis Walter and Eliza Hall Institute of Institute of Medical Research, Brisbane, QLD Medical Research, Melbourne, VIC

34 35 2005 Collaborations 2005 Collaborations Research Collaborations Research Collaborations

Tierney Dr ML Role of ICOS in systemic and Effects of antioxidants and glucocorticoids on Young Professor IG Effects of mutations in M2 on the conductance of organ-specific autoimmunity plasma F2-isoprostane concentrations Role of IL-3 receptor in myeloid leukaemia GABAA receptors Dr A Hutloff Robert Koch Institute, Berlin, Germany Associate Professor K Croft School of Medicine and Dr K F Bradstock Department of Haematology, Pharmacology, Royal Perth Hospital Unit, University Dr B Cromer St Vincents Institute of Medical Vinuesa Dr CG and Cook Dr M Westmead Hospital, Westmead, Sydney Research, Melbourne, VIC of Western Australia, Perth, WA Professor Y Chen Fujian Medical University, APOSLE study- Identification of susceptibility A universal approach towards the design, Optimising microarray in experimental hypertension Fuzhou, China alleles in Australian SLE patients expression and characterisation of soluble ligand- Professor W Anderson Department of Physiology, Subcellular targeting of photosensitizers and other Dr S Addlestein Royal Prince Alfred Hospital, binding domains of ligand-gated ion channels School of Biochemical Sciences, Monash University, locally acting drugs with application in Sydney, NSW Dr N Unwin MRC Laboratory of Molecular Biology, Melbourne, VIC cancer therapy Dr S Riminton Repatriation General Hospital, Cambridge, UK Plamsa BH4 analysis Dr AS Sobolev Department of Biophysics, Moscow Concord, NSW Dr J Earl Department of Clinical Biochemistry, The State University, Moscow, Russia Dr D Fulcher Westmead Hospital, Westmead, NSW Tremethick Dr DJ Children’s Hospital at Westmead, Westmead, NSW Dr S Alexander Children’s Hospital, Westmead, NSW The role of histone variants in modulating Gene expression in glucocorticoid induced Dr P Pavli The Canberra Hospital, Canberra, ACT chromatin fibre dynamics hypertension in rats r Department of Biochemistry and Dr K Luge Walmsley Professor B Dr R Lin School of Biotechnology and Biomolecular Molecular Biology, Colorado State University, Fort Mechanisms of central neuronal integration Sciences, The University of New South Wales, Collins, USA Professor REW Fyffe Wright State University, Sydney, NSW The structure and function of histone variants Dayton, USA during spermatogenesis Membrane properties of auditory neurons Dr C Caron Institut Albert Bonniot, Grenoble, France Professor ID Forsythe University of Leicester, Imprinted X inactivation in Mammals Leicester, UK Dr J Lee Massachusetts General Hospital, In vivo recordings of auditory neurons in Boston, USA congenitally deaf mice Chromatin remodelling during X inactivation Dr AG Paolini La Trobe University, Melbourne, VIC Dr Steve Gerondakis visited Dr E Heard Curie Institute, Paris, France the laboratory of Warren Dr HS Vinuesa Dr CG Professor Frances Shannon Lectin-like transcript-1 (LLT1) as a ligand for the Role of SAP in follicular helper T cell (TFH) inhibitory human NKRP1A inhibitory receptor differentiation Professor L Lanier Department of Microbiology and Dr J Cannons and P Schwartzberg National Human Immunology, University of California, San Francisco, USA Genome Research Institute, National Institutes of Analysis of NK cells and T cells in cord blood of Health, Bethesda, USA preterm babies Molecular mechanisms regulating germinal centre Dr A Kent Department of Neonatology, The B cell selection and memory formation Canberra Hospital, Canberra, ACT Dr R Brink Centenary Institute of Cancer Medicine Dr J Dahlstrom Department of Anatomical and Cell Biology, Sydney, NSW Pathology, The Canberra Hospital, Canberra, ACT Memory formation in germinal centres Professor I MacLennan MRC Centre for Immune Whitworth Professor JA and Zhang Dr Y Regulation, University of Birmingham, Birmingham, UK Glucocorticoid receptors in knockout mice Identification of ROQUIN allelic variants in patients Dr TJ Cole Department of Biochemistry and with familial SLE Molecular Biology, Faculty of Medicine, Nursing and Dr J Harley Arthritis and Immunology Program, Health Sciences, Monash University, Melbourne, VIC Oklahoma Medical Research Foundation, Mechanism(s) by which glucocorticoids induce Oklahoma, USA hypertension in humans Identification of ROQUIN allelic variants in patients Dr J Kelly and Dr G Mangos St George Hospital, with familial Type 1 Diabetes Sydney, NSW Professor G Morahan Diabetes Research Centre, Centre for Medical Research, University of Western Australia, Perth, WA

36 37 Visitors to JCSMR 2005 Visitors 2005 We have welcomed colleagues from Australia and overseas into The John Curtin School of Medical Research throughout 2005, to share their research findings or to spend various periods of time in JCSMR laboratories collaborating with our staff and students. Visitors

Ballard Professor B Hart Professor D Pugh Professor EN University of Iowa, Iowa City, USA Mater Medical Research Institute, Brisbane, QLD University of Pennsylvania, Philadelphia, USA Barry Dr S Hascall Professor V Rasco Professor J Department of Paediatrics, University of Adelaide, Orthopaedic Research Center, Department of Centenary Institute of Cancer Medicine and Cell Adelaide, SA and Child Health Research Institute, Biomedical Engineering, Lerner Research Institute, Biology, Sydney, NSW Adelaide, SA Cleveland, USA Reinholz Dr F Belz Dr G Hashitani Dr H Lions Eye Institute, Perth, WA The Walter and Eliza Hall Institute, Melbourne, VIC Department of Physiology, Nagoya City University Rolstad Professor B Medical School, Nagoya, Japan Brink Dr R Department of Anatomy, University of Oslo, Professor Ian MacLennan Centenary Institute of Cancer Medicine and Cell Heath Professor W Oslo, Norway Biology, Sydney, NSW The Walter and Eliza Hall Institute, Melbourne, VIC Salamonsen Professor L Carbone Professor F Hume Professor D Prince Henry’s Institute of Medical Research, Department of Microbiology and Immunology, The Institute for Molecular Bioscience, The University of Melbourne, VIC University of Melbourne, Melbourne, VIC Queensland, Brisbane, QLD Sedger Dr L Cromer Dr B Johnson Mr A Westmead Millenium Institute, Sydney, NSW Biota Structural Biology Laboratory, St Vincent’s Laboratory for Immunology, National Institutes of Tangye Dr S Institute, Melbourne, VIC Health, Bethesda USA and Centre for Centenary Institute of Cancer Medicine and Cell Human Genetics, Oxford University, UK Daniel J Biology, Sydney, NSW The Garvan Institute of Medical Research, Sydney, NSW Jones Dr A Thompson Dr R Department of Medical Biochemistry and Edwards Professor SV Department of Surgery, The University of Melbourne, Microbiology, Uppsala University, Uppsala, Sweden Department of Organismal and Evolutionary Biology, St Vincent’s Hospital, Melbourne, VIC Harvard University, Boston, USA Khanna Dr R Ward Dr AC Queensland Institute of Medical Research, Brisbane, QLD Fry Dr BG School of Biological and Chemical Sciences, Deakin Australian Venom Research Unit, School of Medicine, King Dr C University, Burwood, VIC Professor Michael Good The University of Melbourne, Melbourne, VIC The Garvan Institute of Medical Research, Sydney, NSW Watson Dr S Gerondakis Dr S Lieberman Professor J Department of Microbiology and Immunology, The Walter and Eliza Hall Institute, Melbourne, VIC CBR Institute for Biomedical Research, Harvard University of California, San Francisco, USA Medical School, Boston, USA Godfrey Associate Professor D Williams Dr S Department of Microbiology and Immunology, The Littlejohn Dr T MRC Laboratory of Molecular Biology, Cambridge, UK University of Melbourne, Melbourne, VIC IBM Australia Ltd, St Leonards, NSW Yang Dr N Good Professor M Lüscher Professor H-R University of Sydney, Sydney, NSW Queensland Institute of Medical Research, Brisbane, QLD University of Bern, Bern, Switzerland Yeo Mr P Gresshoff Professor PM MacLennan Professor I Agency for Science Technology and Research (A*STAR) ARC Centre of Excellence for Integrative Legume MRC Centre for Immune Regulation, University of and Singapore Economic Development Board Research, The University of Queensland, Brisbane, QLD Birmingham, Birmingham, UK Hannan Dr RD Plebanski Professor M Growth Control Laboratory, Peter MacCallum Cancer The Austin Research Institute, Melbourne, VIC Centre, Melbourne, VIC

38 39 Staff, Students & Invited Presentations

A full directory listing of staff and students of The John Curtin School of Medical Research appears in the following pages.

Included is a list of invited scientific presentations made by our staff and students at conferences and at other research institutions both nationally and internationally throughout the year.

The John Curtin School of Medical Research Annual Review 2005

40 Division of Immunology and Genetics (DIG) Staff 2005 & Staff 2005 Presentations Staff 2005 Division of Immunology and Genetics

Professor and Head Gautam A, BSc (Meerut), MSc (Brunel), PhD (Lond) (until April) Technical Officers Howard D, BSc Parish CR, BAgrSc (UMelb), PhD (UMelb) Johnson-Saliba M, BSc(Hons), MSc (Cape Town), PhD Brown D, AsDipAppPath (CIT) (part-time) Liang R, BMed (Zhongshan), MMed (Xi’an Jiaotong) (until November) Hamilton P, Certificate II in Animal Technology (CIT) (from February) School Technical Support Officer Mims C, BSc, MD (Lond) Harris K, BAppSc (H Biol) (UC), DipAppScMedLabTech (CIT) Pulsford K, DipAppSci (CIT) (until March) Woodhams CE, BAppSc (CCAE), GradDipInfSyst (UC) Miliotis C, MBBS (UNSW) (until May) (part-time)(until November) In charge of flow cytometry Senior Divisional Administrator Staykova M, PhD (USofia) Popp SK, BSc, AssDipAppSci, Biol (CIT) Dawson S, BAppSci (UC) (until December) Weil ETF School Associate Immunogenomics Group In charge of pre-immune serology Divisional Administrator Buckley I, MBBS, PhD (UMelb) Domaschenz H, PathTechCert (TAFE) Chivas FA Professor and Leader Senior Technical Officers Goodnow CC, BVSc(Hons)(USyd), BScVet(Hons)(USyd), In charge of immune serology Cancer and Human Immunology Group Bezos A, BSc (USyd), MSc (USyd) PhD (USyd), FAA Kucharska E, BSc, MSc (Warsaw) Hornby J, BSc(Hons) (Queens, Belfast) Fellow and Leader Executive Assistant Immune flow cytometry screening team Warren HS, BSc(Hons), PhD (UQ), NHMRC Senior Technical Officers Vitler L Alexander P, BScMedScience (UC) Research Fellow Browne A, BA Senior Research Fellow and Program Leader Curwen P, BAppSci (UC) (until March) Pagler E, BS (Santo Tomas) Research Fellow Regulatory Genes in Diabetes Emmett S, BSc(Hons) (Monash) (from January) Bettadapura J, MSc, PhD (Bangalore) Technical Officer Hoyne G, BSc(Hons) (UWA), PhD (UWA) In charge of genetics Vavrina-Kun A, BMedSci (part-time) Postdoctoral Fellow Research Fellow and Program Leader Genes Angelucci C, BSc(Hons) (Deakin), PhD Alsharifi M, BBioMedSci(Hons) (Monash), PhD (from April) Visiting Technical Officer Controlling Humoral Immune Responses Research Technicians Gomersall T, BAppSc (UC) Technical Officer Vinuesa CG, LMS(MBBS) (Madrid), DRCOG (Lond), MSc, Hogan J, BMedSci, GradDipGenCouns (Newcastle) Hewitt K, BSc Laboratory Technician PhD (Birmingham) (from December) Koffler J, BAppSc (UC) (from January) Jian P (part-time) Research Fellow and Program Leader Genes Visiting Scholar Newman A (April-August) Editorial/Administrative Assistant Van Roon J, BSc (Utrecht) (June-November) Controlling T cell Responses Young N, BSc (from January) Gernert A, MA (Ludwig-Maximilians) (until February) Bertram E, BSc(Hons) (Adel), PhD (Adel) Cancer and Vascular Biology Group Transgenic Strain Co-Ordinators (part-time) Fellow Professor and Leader Pulsford K, DipAppSci (CIT) (from March) Parish B, BSc (Madras), BSc, MSc, GradDipCompStudies Horikawa K, MD (Chiba), PhD (Tokyo) Parish CR, BAgrSc (UMelb), PhD (UMelb) (UC) (from February) (part-time) WilliamsM, DipAppSci (Animal Tech) (until April) Postdoctoral Fellows Fellow Research Assistant Computational Genomics Laboratory Enders A, MD (Freiburg) (from August) Wilson A, BSc(Hons) (UC), RN (from June) (part-time) Freeman C, BSc(Hons) (Adel), PhD (Adel) Liston A, BSc(Hons) (Adel), PhD (from January) (from March) Visiting Technical Officer Viertel Senior Medical Research Fellow Mana P, PharmD, MPharm, PhD (Santiago de Compostela) Fellow and Leader Watson S, BSc(Hons) (Edin), PhD (Lond) (July-October) Hulett M, BSc(Hons) (UMelb), PhD (UMelb) (from April) Huttley G, BSc(Hons) (MacqU), PhD (UC Riverside) Research Fellows Rui L, MS (Shanxi), BM (Wannan), PhD (until November) Laboratory Assistants Visiting Fellows Hoyne R (from July) (casual) Hindmarsh EJ, BSc(Hons) (USyd), PhD Silva D, MBBS (Colombia), PhD (from January) Buckley R, BA(Hons) (UQ) (from January) Hynes K, BBMEDS (from February) Rao S, BSc(Hons) (Keele), PhD (Kings College Lond) Tze L, BSc (Beloit), PhD (Minnesota) Robinson A, BSc(Hons), PhD Linterman M, BBMEDS (from February) NHMRC Peter Doherty Postdoctoral Fellow Visiting Fellows Scientific Programmer Templeton M (until February) (casual from May) Simson L, BSc (UC), PhD (from April) Athanasopoulos V, PhD (UMelb) Maxwell P, MSc, DipCompSci (Auckland) Cornall R, PhD Visiting Scholar Postdoctoral Fellows Visiting Scholar Fahrer A, BSc(Hons) (UMelb), PhD (UMelb) Johnson AL, BSc (William Jewell) (until February) De Mestre A, BVSc(Hons) (USyd) (June-July) Cai J, PhD (Hong Kong) (April-October) Yates A, BSc(Hons), PhD Eichner D, BSc(Hons) (from November) Immunopathology Group Laboratory Manager Quah B, BSc, PhD Diabetes/Transplantation Immunobiology Fellow and Leader Townsend M, PathTech Cert (TAFE), AssDipAppPath Simson L, BSc (UC), PhD (until March) Cowden WB, BS (Troy State), PhD (UQ) Laboratory (Bruce TAFE) Research Assistant Fellow and Leader Visiting Fellows Laboratory Technical Staff Jones A, BScAgr(Hons) (USyd), PhD (until March) Simeonovic CJ, BSc(Hons), PhD Eschler B, BSc(Hons) (USyd), DipEd (USyd), MSc (USyd), In charge of molecular biology Visiting Fellows PhD (Wollongong) Visiting Fellows Whittle B, BSc(Hons) Ada GL, DSc (USyd), FAA McCullagh P, MBBS (UMelb), DPhil (Oxon), MRCP (Lond), Francis D, BVSc (USyd), MVSc (USyd), PhD (USyd) Genotyping team Altin J, BSc, GradDipSci, PhD MD (UMelb) (until December) Buckle D, BSc(UMelb), MSc (Auckland) Burch WM, BSc (UMelb), MSc (UMelb), PhD (Lond) Wilson JD, BSc(Hons), MBBCh, BAO(Hons), MD (Queens, Jenkins NF, BSc(Hons) (Adel), PhD (Adel) (until February) Ewing S, BiolTechCert (TAFE) Chesterman C, MBBS (USyd), DPhil (Oxf), FRACP, FRCPA Belfast), MRCP (UK), FRACP March D, BSc(Hons) (Adel), PhD (Qld) Cooper PD, DSc, PhD (Lond) Hamilton A, DipPathTest (CIT) 42 43 Staff 2005 Staff 2005

Division of Immunology and Genetics Division of Immunology and Genetics

Technical Officers Vaccine Immunology Group Australian Phenomics Facility (APF) Horan J (to March) Bartell G, BSc(Hons) (USyd), MSc Professor and Leader Lok A, DipAppSci (Animal Tech) Gapella JP, Animal Tech Cert (TAFE) Facility Director McGhie K, DipAppSci (Animal Tech) (CIT), Vet NursingCert Ramshaw IA, MSc (Brunel), PhD Goodnow CC, BVSc(Hons) (USyd), BScVet(Hons) (USyd), Laboratory Technicians IV (CIT) Research Fellows PhD (USyd), FAA Rankin S Higgins D, DipApplSci (CIT) Ranasinghe C, BSc (Rouen), MPhil (Colombo), PhD (UWA) Rooke M, BMedSci Lejsek E, BSc, Grad Dip (CSU) (until April) Head of Operations Thomson S, BSc (USyd), PhD (UQ) McKenzie A, BSc(Hons) (Monash) Vlazlovski D Visiting Technical Officers Gaffey L, BSc (ANU) (from February) Postdoctoral Fellows Head of Finance and Administration Martin L, BSc (Newcastle) (from June) Roots C, BAppSci (UC) Amyes E, DPhil (Oxon) (from March) Baker L, Bbus(Acc) (UnivTechSyd), CPA (Deakin) Pavlinovic L (from May) Juelich T, BSc(Hons) (Stuttgart), PhD (from April) Brouwer L (from February) Administrative Support Officer Connell M, BSc (Uni Melb) (from April) Infection and Immunity Group Research Assistant Ovchynik K, BA (Charles Sturt) (from October) Whiffen K (from May) Senior Research Fellow and Leader Harrison J, BSc(Hons) (Adel) (from November) Head of Programming Hunt B (from May) Karupiah G, BSc(Hons), MSc (Malaya), PhD Visiting Fellows Quinn G, BSc, GradDipComputing (CCAE) Cumming C, Cert III Animal Tch (CIT) (from May) International Research Scholar of the Howard Hughes Jackson RJ, BSc(Hons) (Monash), PhD (Edin) Building Maintenance and Services Co-ordinator Medical Institute Ramsay AJ, BSc, PhD (Otago) Head of Scientific Programs Bertram E, BSc(Hons) (Adel), PhD (Adel) Hosking A (from April) Research Fellow Laboratory Manager Material Support Coordinator Chaudhri G, BSc(Hons), PhD Medveczky CJ, AssocDipTechBiol (TAFE) Software Systems Group Manager Porter D, BCompSc Hons (UNE) (from November) Hebda D Postdoctoral Fellow Senior Technical Officers Material Support Technicians Panchanathan V, MBBS, MPhil (Malaya) McArthur C, BSc (Flinders), MSc IT Officers Gee A, BInfoTech (UC) (to March) Hebda A Visiting Fellows Shoobridge M, BSc(Hons) Satrapa A, BEng(Comp Software) (UC) Korres F (to July) Belz G, BVBiol (UQ), BVSc(Hons) (UQ), PhD (UQ) Technical Officers Porter D, BCompSc Hons (UNE) (from January to November) Mullavey M (to February) Fang Y-Y, BMed (Shanghai), PhD (Adel) Gao K, BSc (ShanDong), MPhil Prewett B Unit Coordinator (August-December) Nolan L, BAppSci (UC) Smith D Campbell K, AssocDipAppSci (Animal Science), AdvCertVet Foxwell R, BSc (WA), BSc(Hons) (UMelb), MSc (Lond), PhD Woltring D, AssDipBiol (CIT), AssDipPath (CIT), BSc Davey W (from January) Nursing (CIT) (UC), Grad Cert Higher Ed (UC) Lorenzi L (from April) Scalzo A, BSc(Hons) (UMelb), PhD (UMelb) Viral Immunology and Molecular Virology Library Coordinator Howe C (from April) Senior Technical Officers Group Chaudhry S, AssocDipAppSci (Animal Science) (CIT) Reppion M (from April to October) DeChazal R, Assoc Dip Animal Science (CIT) Professor and Joint Leader Veterinary Pathologist IVF/Cryopreservation Technician (until November) Müllbacher A, BSc, MSc (Auckland), PhD Courtman N, BVsc MACVSc MVSc Adams V, AdvCertVetNursing Tha Hla R, BRTC (TAFE) Fellow and Joint Leader Phenome Bank Curator Senior Cryopreservation Scientist Zhou J, BMed, (Beijing Medical University), MMed (USyd) Lobigs M, BSc(Hons), PhD Read S, BScHons, PhD (Adel) Sanchez-Partida G, PhD Laboratory Technician Research Fellows Phenotyping Coordinator Genotyping and Mapping Coordinator Jian P (part-time) Lee E, BSc(Hons), PhD Whiting I Whittle B, BSc(Hons) (60%) Regner M, PhD Predictive Medicine Group (from February) Quarantine Coordinator Genotyping and Mapping Technicians (formerly Human Genetics Group) Visiting Fellows Rogis N, DipAppSci (Animal Tech) (CIT) Buckle D, BSc (UMelb), MSc (Auck) Blanden RV, MDS (Adel), PhD, FAA Ewing S, BiolTechCert Professor and Leader Senior Animal Technicians Chin J, MSc(Hons) (UQ), PhD (UQ) Hamilton A, DipPathTest Easteal S, BSc (St Andrews), PhD (Griffith) White A, DipAppSci (Animal Tech) (CIT) Waring P, BSc(Hons) (UQ), MSc, PhD Liang R, BMed, MMed (ObsGyn) Postdoctoral Fellow Wilson J, AssocDipAppSci (Animal Science) (CIT) Senior Technical Officer Wakefield M, BSc(Hons) (UMelb), PhD (La Trobe) Koskinen A, AssocDipMedSci Animal Technicians (until July) Anderson C Technical Officers Visiting Fellow Avakian M, BSc Pavy M, AssDipAppSci (CIT) Mack H, BS, PhD (Penn State) (from September) Barich K Young N, BSc (until January) Bodel R, DipAppSci (Animal Tech) Senior Technical Officer Craven A, BAnimal Science (JCU) Tan X, BSc, (Shandong), MSc (China Pharmaceutical) Dey B, (from November) Visiting Scholar Dunn C Mather K, BSc(Hons) (La Trobe), BSc(Hons), Gambell R, DipAppSci(Animal Tech) (CIT) GradDipPsy (CSU) 44 45 2005 Presentations 2005

Presentations Presentations Division of Immunology and Genetics Division of Immunology and Genetics

Centre for Bioinformation Science Scientific Programmers How do neutrophils, plasmacytoid dendritic cells Ranasinghe Dr C Butterfield A, BSc(Hons) (Canterbury NZ) (80%) and NK cells influence the adaptive antiviral Characterisation of HIV fowl pox virus/ vaccinia Fellow Lawrence C, BSc(Hons), MA (Delaware), GradDipCompSci immune response? Huttley GA, BSc(Hons) (MacqU), PhD (California) virus mucosal and systemic prime boost vaccines (UNSW) (80%) Howard Hughes Medical Institute Scientific Meeting (until March) Australian Centre for Hepatitis Virology & HIV of International Research Scholars, Mérida, Mexico Virology, Terrigal, NSW Research Fellows Immunity to virus infections: Lessons from Characterisation of HIV pox-virus mucosal and Booth H, BSc (Adel), PhD (UNE) (Deceased) mousepox and smallpox systemic prime boost vaccines Burden CJ, BSc(Hons) (UQ), PhD NSW/ACT Australian Society for Immunology Inc Fang Y, BSc, MSc (Jilin), PhD (Massachusetts) AIDS Vaccine 2005 Conference, Montreal, Canada Wakefield M, BSc(Hons) (UMelb), PhD (La Trobe) (80%) Retreat, Wiseman’s Ferry, NSW How does our immune system fight virus infections? Regner Dr M The 6th Ranjeet Bhagawan Singh Technical Workshop The role of granzymes in the immune response to on “New Methods for Monitoring Immunity”, Kuala Ectromelia Infection Lumpur, Malaysia International Symposium on Apoptosis, Cairns, QLD Immune response to virus infection Simson Dr L The 6th Ranjeet Bhagawan Singh Technical Workshop The role of Th2-mediated immunity in tumour on “New Methods for Monitoring Immunity”, Kuala immunosurveillance Presentations 2005 Lumpur, Malaysia Tumour Immunology Workshop, Australasian Society Parish Professor C for Immunology, Adelaide, SA Chaudhri Dr G Huttley Dr G Heparin sulfate mimetics: A new class of anti- Innate immune responses direct adaptive Estimates of dependent substitution rates reveal angiogenic and anti-metastatic drugs immunity to virus infection the impression of tertiary protein structure Eosinophils: Key effector cells in The 3rd Congress of the Federation of Immunology Lorne Genome Conference, Philip Island, VIC anti-tumour immunity Societies of Asia-Oceania, Hangzhou, China PyEvolve: a toolkit for statistical molecular Tasmanian Haematology, Immunology and Neoplasia The adaptive immune response evolutionary analysis of genomes Group, Hobart, TAS The 6th Ranjeet Bhagawan Technical Workshop on Joint Genetics Society of Australia and the Annual Cancer elimination by tumour-specific Th2 cell “New Methods for Monitoring Immunity”, Kuala meeting of the Society for Molecular Biology and 3rd Congress of the Federation of Immunology Lumpur, Malaysia Evolution, Auckland, New Zealand Societies of Asia-Oceania, Hangzhou, China Towards Predicting the Epigenome: A Comparative New approaches to cancer Hulett Dr M Genomic Approach Australasian Society for Immunology Workshop, The heparan sulphate degrading enzyme Sir Mark Oliphant conference: Epigenetic regulation Perth, WA heparanase: molecular characterization and in disease and development, Canberra, ACT Heparin sulfate mimetics: A new class of anti- targeting with drug inhibitors to treat cancer and angiogenic and anti-metastatic drugs inflammatory disease Karupiah Dr G Mater Hospital Special Grand Rounds, Brisbane, QLD Mater Medical Research Institute, Mater Hospital, Immunity to poxviruses New approaches to cancer immunotherapy Brisbane, QLD National Institutes of Allergy and Infectious Diseases Mater Medical Research Institute, Brisbane, QLD The Austin Research Institute, Austin Hospital, Fifth Poxvirus Workshop, Bethesda, USA Bystander B cells rapidly acquire antigen receptors Melbourne, VIC Immunity to poxvirus infections: use of antivirals from activated B cells by membrane exchange. A Centre for Vascular Research, The University of New to enhance the immune response novel mechanism for enhancing specific South Wales, Sydney, NSW Australia-USA Poxvirus workshop, Bethesda, USA antigen presentation The plasma protein Histidine-rich glycoprotein is The role of antibody in recovery from primary and 35th Annual Scientific Meeting of the Australasian a regulator of Immune Complex Clearance and secondary poxvirus infections Society for Immunology, Melbourne, VIC Phagocytosis of Necrotic cells Laboratory of Viral Diseases, National Institutes of 35th Annual meeting for the Australasian Society for Allergy and Infectious Diseases, Bethesda, USA Immunology, Melbourne, VIC

46 47 Division of Molecular Bioscience (DMB) Staff 2005 & Staff 2005 Presentations Staff 2005 Division of Molecular Bioscence

Professor and Head of Division Research Fellows Cytokine Molecular Biology and Technical Officer Shannon MF, BSc(Hons), PhD (National University of Ireland) Ridgway P, BSc (McMaster), MSc (Queens, Canada), PhD Signalling Group Curmi J, BOptom(Hons) Fan J, BSc (Fudan), MSc (Fudan), PhD (Auckland) Wei B, BMed (China) Divisional Technical Manager Professor and Group Leader Rangasamy D, BSc, M Tech (India), PhD (Hull) Lui L, BSc, PhD Taylor R Young IG, MSc (UMelb), PhD Postdoctoral Fellow Divisional Administrator Postdoctoral Fellows Molecular Genetics Group Greaves I, PhD Mitigas R Soboleva T, MSc (MSU), PhD Professor and Leader Technical Officer Chen J, MMed (China), PhD (Flinders), BSc (China) Board P, BSc(Hons), PhD (UNE) Assistant Administrator Devoy M, BSc(Hons) Funari R (until May) Research Assistant Research Fellows: Smith T (June–Dec) Laboratory Technician Ford S, BA, MSc (UQ) Blackburn A, BSC(Hons) (UNSW), PhD Young S (casual) Fan Y-Y, BMed (China), PhD (Adel) (until April) Laboratory Stores Attendant Technical Officers Murray E (until April) Computational Proteomics and Therapy Olsen J, BSc Postdoctoral Fellows Design Group Conlan F, BSc(Hons) (Wollongong) (until August) Shield A, BBiotech(Hons) (Flinders), PhD (Flinders) Allergy & Inflammation Research Group Craig S, BSc(Hons), PhD (UNSW) Professor and Leader Gene Targeting Laboratory Professor and Group Leader Visiting Fellows Gready JE, BSc(Hons), PhD (USyd) FRACI Senior Fellow and Head Foster P, BSc(Hons) (WA), PhD Cavanaugh J, BSc, MS (North Carolina State), PhD Research Officers Matthaei KI, BSc(Hons) (UNSW), PhD Research Fellows Dahlstrom J, MBBS(Hons), FPAC, PhD, FRCPA, Cummins PL, BSc(Hons), PhD (USyd) Webb D, BAppSc, PhD (UC) Postdoctoral fellow GradCertEdSt Rostov IV, BSc (Kazan), PhD (Karpov Institute) (half-time) Phipps S, BSc(Hons) (Bath), PhD (Imperial College) Hogan SP, BSc(Hons), PhD (until May) Senior Technical Officer Postdoctoral Fellows (until June) Phipps S, BSc(Hons) (Bath), PhD (Imperial College) (from Coggan M, BSc(Hons) July) Kannappan B, BSc (Madras), MSc, PhD (Pune) Visiting Fellow Laboratory Technicians Zelensky AN, BSc, MSc (Kiev-Mohyla) Hopkinson K, DipAppSc (UC), BAppSc (UC), Dip APMA Postdoctoral Fellows Brew J, BSc (part-time) Research Assistant (Monash) (from November) Yang M, Bachelor of Medicine (West China), PhD Bessell R, (part-time) Vassilieva T, MSc (Novosibirsk) Visiting Fellow Visiting Scholar Cappello J, BSc (UC), AD AppSciAnSci (CIT) Denborough M, MD, ChB (Capetown), MD (UMelb), DPhil Visiting Fellows Matthaei NK (from December) Karunasekara Y, MD (Vinnitsa) (Oxon), DSc (UMelb), FRCP Armarego WLF, PhD, DSc (Lond), FRSC, FRACI Laboratory technicians Liu D, PhD (USyd) Bliznyuk A, BSc, PhD (Novosibirsk) Murray T, BSc(Hons), BMedSci (USyd) Laboratory Technician Damcevski VW, AssDipAppSci (CIT) Graves JAM, BSc, MSc (Adel), PhD (UC Berkeley) Yeping C Kugathas K, DipMedLabSci (CIT) Muscle Research Group Visiting International Scholar Langton LK, BSc, AssDipSci (until May) Biomolecular Structure Laboratory Crecca C, BSc (Bloomsburg) Newhouse MJ, BSc, Grad Dip (until February) Professor and Group Leader Dulhunty AF, BSc (USyd), PhD, DSc (UNSW) Fellow and Leader Taylor HI Casarotto MG, BSc(Hons) (UMelb), PhD (UMelb) Cytokine Gene Expression Laboratory Postdoctoral Fellow Professor and Leader Membrane Physiology and Biophysics Beard N, BAppSci(Hons) (LaTrobe), PhD Postdoctoral Fellows Shannon MF, BSc(Hons), PhD (National University of Ireland) Professor and Leader Kimura T BSc(Hons) (Osaka), PhD Cui Y, MA (Central China), PhD (Chinese Academy Gage P, MB ChB (NZ), PhD, DSc (UNSW), FAA (Deceased) of Science) Postdoctoral Fellows Research Fellow Harvey P, BSc(Hons) (Griffith), PhD (Griffith) Juelich T, BSc(Hons) (Stuttgart), PhD (until June) Research Fellow – Acting Leader Pouliquin P, BSc(Hons) (Ferrara) Craig S, BSc(Hons) (UNSW), PhD (UNSW) (from May) Wilkinson N, PhD (Texas) Tierney ML, BSc, MSc (Otago), PhD Visiting Fellows Wang J, BSc (Xinjiang), MSc (Weizmann Institute), PhD Technical Officers Postdoctoral Fellows Laver D, BSc(Hons), PhD (UNSW), (ARC) Premzl M, DVM, MSc (Zagreb) (until March) Morris M, BBiomedSci(Hons) (JCU) (until March) Premkumar A, BSc, MSc, PhD Gallant E, PhD, (Minnesota) Hardy K, BSc(Hons) (USyd), PhD (USyd), Masters(EScience) Norris N, BSc(Hons) (USyd) (until September) Ozsarac N, BSc(Hons), PhD (From June) Technical Officer Karunasekara Y, MD (USSR) Wu W, BSc, PhD Curtis S, BSc, PLTC (half time) Rosenberg M, BSc(Hons) (Canterbury) (until August) Senior Technical Officer and Laboratory Manager Lu T, BSc(Hons), PhD Senior Technical Officer Palmer S, BSc(Hons), Grad Dip (Tech Management) (Monash) Visiting Fellows Chromatin and Transcriptional Regulation Pace S, BSc (UTS) Laboratory Technical Officer Cromer B, BSc(Hons), PhD Ma L, MAppSci (Horticulture) (NZ) Ewart G, BSc(Hons), PhD Laboratory Technicians Fellow and Leader Stivala J Tremethick DJ, BSc(Hons) (USyd), PhD (MacqU) Culley D, BSc

48 49 2005 Presentations 2005 Presentations Presentations Division of Molecular Bioscence Division of Molecular Bioscence

Ubiquitin Laboratory Divisional Visiting Fellows Gready Professor JE Shannon Professor MF Fellow and Leader Barlin G, PhD, DSc (USyd), FRANC Elusive players in enzyme catalysis: defining The role of chromatin in inducible gene Baker R, BSc(Hons) (UNSW), PhD Cox G, BSc, PhD (UMelb), FAA protonation states and hydride-ion transfer transcription in the immune system Denborough M, MD, ChB (Cape Town), MD (UMelb), Technical Officer mechanisms and energetics Department of Immunology, Monash Medical Centre, DPhil (Oxon), DSc (UMelb), FRCP McIntyre M, BSc(Hons) (UWA), GradDipEd (UC) Plenary Lecture, WATOC05 (World Association of Melbourne, VIC Gibson FEW, BSc, DSc (UMelb), MA, DPhil (Oxon), FAA, FRS Theoretically Oriented Chemists), Cape Town, The role of chromatin in inducible gene Laboratory Technician Morrison JE, BSc (USyd), MSc (UQ), DPhil (Oxon), DSc South Africa transcription in the immune system French H, BSc(Hons) (Otago) (from February) Spinner E, MSc Tech, PhD, DSc (Manchester), FRACI Simulations of enzyme reaction mechanisms in Child Health Research Institute, Adelaide Women’s Visiting Scholars active sites: accounting for an environment which and Childrens Hospital, Adelaide, SA Belbin B, BSc(Hons) (Newfoundland) (until April) is much more than a solvent perturbation Inducible gene transcription, chromatin and the Cunningham E, BMedSci(Hons) (USyd) (January) Symposium to Commemorate the 80th Birthday of immune system Wong R, (February-May) Professor Noel Hush, University of Sydney, Sydney, NSW A Sir Mark Oliphant Conference, International Riester D, (Stuttgart) (March-December) Frontiers of Science and Technology, Epigenetic Girhard M, (Stuttgart) (May-December) Matthaei Dr KI Regulation in Disease and Development, CSIRO, Tissue and temporal specific KO and transgenic mice Canberra, ACT Kioloa Neuroscience meeting, Kioloa, NSW Homologues of the Drosophila melanogaster Tierney Dr ML flightless I (fliI) gene Are extra-synaptic GABAA receptors clustered? Centre for Molecular Genetic Development, Annual Speaker and Chair: Australian Physiological Society meeting, Adelaide, SA and Australian Biophysics Society, joint meeting, Towards tissue and temporal control of gene Canberra, ACT function in vivo Tremethick Dr DJ Annual Newcastle Asthma Meeting, University of Chromatin Structure and Function Newcastle, Newcastle, NSW FASEB Meeting, Snowmass Colorado, USA Presentations 2005 Gene targeted and transgenic mice: providing all the answers or just creating more problems Young Professor IG Baker Dr RT Foster Dr P University of Canberra, Canberra, ACT The Lemberg Plenary Lecture Roles of deubiquitylating enzymes in ubiquitin- Invited Speaker Newhouse Mr M Combio 2005, Adelaide, SA Invited Speaker dependent processes 9th International Conference on Human Leucocyte Toll-like receptors in mouse models of International Society of Interferon and Cytokine Child Health Research Institute, Adelaide, SA Differentiation Antigens and 35th Annual Scientific airways disease Research conference, Shanghai, China Deubiquitylating enzymes: structure, function, and Meeting of the Australasian Society for immunology, Annual Newcastle Asthma Meeting, University of regulation of ubiquitin-dependent processes Melbourne, VIC Newcastle, Newcastle, NSW , Townsville, QLD Invited Speaker Chair Mini-symposium (educational section), Asthma Board Professor P and Arginase, The American Academy of Asthma, New members of the glutathione transferase Allergy and Immunology 60th annual meeting, San structural family with novel functions. Antonio, USA New Zealand Society for Biochemistry and Molecular Invited Speaker Biology, Dunedin, New Zealand Chair, Symposium Chemokines and Receptors Dulhunty Professor AF The American Academy of Asthma, Allergy and AuPS Invited Speaker Immunology 60th annual meeting, San Antonio, USA Combined meeting of the Australian Physiology Invited Speaker Society and the Australian Biophysics Society Fourth International Eosinophil Symposium, Bern, Switzerland Invited Speaker International Inflammation Meeting, Melbourne, VIC

50 51 Division of Neuroscience (DNS) 2005 Presentations & Staff 2005 Presentations Staff 2005 Division of Neuroscience

Head of Division Laboratory Technician Hill CE, BSc, PhD, DSc (UMelb) (until October) Holgate J, BAppSc (UC) Presentations 2005 Stuart GJ, BSc (Monash) PhD (from October) Postdoctoral Fellow School Technical Support Officer Kaasinen SK, MSc, PhD (Kuopio) Taylor R Visiting Fellow Bekkers Dr JM Lamb Professor TD Divisional Administrator Megirian D, MS, PhD (Rochester) Puzzles of the piriform cortex Phototransduction, dark adaptation and the Lukatela M, BA, GDipLib (CCAE) (until November) Movement & Memory Laboratory The Redman Symposium on Fundamental Mechanisms retinoid cycle of vision McNaughton E (casual) in the Central Nervous System, Heron Island, QLD Alcon Research Institute, Fort Worth, USA Radcliffe J (from November) Professor and Leader Neural processing in the primary olfactory cortex First stage of vision: transduction and adaptation Redman SJ, ME (UNSW), PhD (Monash), DSc (Monash), FAA Divisional Assistant Queensland Brain Institute, Brisbane, QLD in retinal photoreceptors Dorais C University Fellow and Emeritus Professor Australian Academy of Science, Canberra, ACT Curtis DR, AC, MBBS (UMelb), PhD, FRACP, FAA, FRS Cowan Dr A Federation Fellowships and ARC Centre of Autonomic Neuroeffector Transmission Synaptic transmission and presynaptic calcium stores Research Fellows Excellence in Vision Science Laboratory The Redman Symposium on Fundamental Mechanisms Cowan AI, BSc(Hons) PhD Ministerial announcement of ARC Funding, in the Central Nervous System, Heron Island, QLD Professor and Leader Raymond C, BSc(Hons) (Otago), PhD (Otago) Parliament House, Canberra, ACT Hirst GDS, BSc, PhD (Leeds), FAA Senior Technical Officer Hill Professor CE Molecular basis of the photoreceptor’s electrical Fellows Rodda GR, PTC Mechanisms underlying vasomotion response to light Edwards FR, BE, PhD (Monash) Symposium on ‘Endothelium-Vascular Smooth Engineers Australia, Canberra, ACT Yanagida H, MD, PhD (Nevada) Neuronal Network Laboratory Muscle Interactions’: Australian and New Zealand Raymond Dr C Laboratory Technician Associate Professor and Leader Microcirculation Society, Hunter Valley, NSW LTP-related Ca2+ signals Garcia-Londono AP, BVSc (Caldas) Stricker C, MD (Zurich), PhD (Bern) Role of nifedipine-insensitive calcium channels in The Redman Symposium on Fundamental Mechanisms the control of cerebral vascular tone Blood Vessel Laboratory Neuronal Signaling Laboratory in the Central Nervous System, Heron Island, QLD International Symposium ‘Frontiers of Vascular Leader Professor and Leader Medicine’: Melbourne, VIC Stricker Associate Professor C Stuart GJ, BSc(Hons) (Monash), PhD Hill CE, BSc, PhD, DSc (UMelb) Ruling the Waves: Voltage dependent and Homeostatic mechanisms in the brain Postdoctoral Fellows Postdoctoral Fellow independent control of vasomotion The Redman Symposium on Fundamental Mechanisms Goto K, PhD, MD (Kyushu) (until September) Kampa B, DipBiol (Freiburg), PhD (until October) Centenary Lecture Programme, Department of in the Central Nervous System, Heron Island, QLD Kole MHP, MSc, PhD (Groningen) Grayson TH, BSc (UTas), MSc, PhD (Plymouth) Physiology, University of Otago, New Zealand Stuart Dr GJ Senior Technical Officer Research Fellow Ruling the Waves: Voltage dependent and The mechanics of memory Brackenbury T, BSc(Hons), BSc (Natal), MSc, PhD Gulledge A, BSc(Hons) (UCalifornia), PhD (Texas) (until May) independent control of vasomotion Brain Awareness Week, Canberra, ACT (until September) University of Newcastle, Newcastle, NSW Synapse & Hearing Laboratory Properties and function of HCN channels in Research Officer Professor and Leader Hirst Professor GDS physiology and pathology of the CNS Belfrage KR, BSc(Hons) (La Trobe) Walmsley B, BE, PhD (Monash), DSc (UNSW) Role of interstitial cells of Cajal in the control of Department of Anatomy and Cell Biology, University Brain Modeling Laboratory Postdoctoral Fellows gastric motility of Melbourne, Melbourne, VIC Leader Berntson A, BA (Minnesota), PhD International Meeting on Smooth Muscle, Nagoya, Japan Action potential initiation in layer five Clements JD, BSc (Monash), PhD Leao R, BSc, MD (UFU), PhD (from October) Propagation of slow waves in the guinea pig stomach pyramidal neurons 4th International meeting on Interstitial Cells of Cajal, MRC Laboratory of Molecular Biology, Cambridge, UK Cerebral Cortex Laboratory Visual Neuroscience Laboratory Hawaii, USA Properties and function of HCN channels in Fellow and Leader Professor and Leader Neurones, cables and smooth muscles physiology and pathology of the CNS Bekkers JM, BSc (Griffith), MSc (Manchester), Lamb TD, BE (UMelb), ScD (Cantab), FRS, FAA The Redman Symposium on Fundamental Mechanisms Queensland Brain Institute, University of Queensland, PhD (Cambridge) Postdoctoral Fellows in the Central Nervous System, Heron Island, QLD Brisbane, QLD Postdoctoral Fellow Cameron AM, BPsych(Hons) (JCU), PhD (UQ) Dendrites: the brain within the brain, and how I Suzuki N, BSc (Tsukyba), MMedSc (Tsukyba), PhD (Tokyo) Järvinen JLP, MSc (Helsinki), PhD (Cantab) got to know about them The Redman Symposium on Fundamental Mechanisms Developmental Neurobiology Laboratory in the Central Nervous System, Heron Island, QLD Professor and Leader Hendry IA, BSc (Med), MBBS (Syd), PhD (Cambridge), DSc (USyd) 52 53 High Blood Pressure Research Unit (HBPRU) & Staff 2005 Presentations 2005 Presentations Presentations Division of Neuroscience Staff 2005

Professor and Head Visiting Fellows Whitworth JA, AC, DSc, MD, PhD, BS (UMelb), MD Kelly JJ, MBBS(Hons), MD (UNSW) Redman Professor SJ (Honoris causa) (USyd), MD (Honoris causa) (UNSW), Schyvens CG, BSc (USyd), PhD (UNSW) Spatial segregation of neuronal calcium signals FRACP, FAICD encodes different formed LTP Visiting Scholars Research Fellow Miao Y, BMed (until March) Centenary Lecture, Physiology Department, Otago Zhang Y, BMed (Beijing), PhD (Adel) Possamai V (January - March) Medical School, New Zealand Invited Guest Lecturer Laboratory Manager The Redman Symposium on Fundamental Mechanisms McKenzie K, AssDipAppSci, Cert III, IT (CIT) in the Central Nervous System, Heron Island, QLD Clinical Research Assistant Williamson PM, SRN (seconded to St George Hospital, Walmsley Professor B Sydney, NSW) ANS Plenary Lecture: From Ear to Eternity Technical Officer The Australian Neuroscience Society Annual Meeting, Walsh C, AdvCertSci (SA) (from July) Perth, WA Synaptic and neuronal mechanisms in central auditory pathways University of Leicester, Leicester, UK Central auditory pathways in congenital deafness Mill Hill MRC Institute, London, UK Presentations 2005 Basic synaptic and neuronal mechanisms in central auditory pathways: insights from Whitworth Professor JA congenital deafness Health and Medical Research in Australia Department of Employment and Workplace Wright State University, Dayton, Ohio, USA ANU Faculty of Science, Dean’s Lecture Series, Relations, Women’s Forum From Ear to Eternity Canberra, ACT International Women’s Day lunch, Canberra, ACT The Redman Symposium on Fundamental Mechanisms Management of the difficult hypertensive patient Role of WHO Global ACHR in the Central Nervous System, Heron Island, QLD Pre-congress training course, 3rd World Congress of Planning Group of the Australian Coalition for Global Nephrology, Singapore Health Research, Canberra, ACT Resistant Hypertension 2003 WHO/ISH Statement on Management 3rd World Congress of Nephrology, Singapore of Hypertension Progression of non-diabetic renal disease: are Australian Nurses’ Cardiovascular and Hypertension ACEI superior? Association conference, Melbourne, VIC Satellite Meeting on Hypertension and the Kidney, Research for policy Perth, WA Sax Institute Health Policy and Research Exchange, Leadership in an academic environment Sydney, NSW Australian Medical Students’ Association, Leadership Health and Medical Research in Australia Development Seminar, Canberra, ACT Medical Sciences Strategic Planning Meeting, Flinders Women in health: not drowning but waving University, Adelaide, SA Pamela Denoon Lecture, Canberra, ACT 2003 WHO/ISH Statement on management UNSW Medical Sciences Graduation Ceremony of hypertension The University of New South Wales, Sydney, NSW Visiting Faculty ISH, Beijing, Shanghai, Wuhan, Leadership in a changing environment Chengdu, China Public Service Commission Workshop, Canberra, ACT Juvenile Diabetes Research Foundation, Zhang Dr Y CEO Luncheon Folic acid prevents and reverses ACTH-induced JDRF, Canberra, ACT hypertension in the rat th Hypertension — a global health problem High Blood Pressure Research Council of Australia 27 The Australian Association of Gerontology 40th Annual Scientific Meeting, Melbourne, VIC Anniversary Conference, Canberra, ACT

54 55 Students at JCSMR 2005 Students 2005

Students Research Programs Research Programs Research

PhD Scholars Abdellatif Y, MLfSci (Kwangju), BSc (Alexandria) Palmer L, BSc (UMelb), BA (UMelb), MSc (Minnesota) Honours Scholars Vacation Scholars (until October) Poon I, BBioMedSci(Hons) (Monash) (from February) Brew JM Cheung S Abraham M, BSc (UTas), MPhil Possamai V Hinton RA, BMedSci French H Alonso H, MSc (Cordoba) Prichard Z, BSc(Hons) Hynes K, BBMEDS (Victoria) Fu S Alsharifi M, BBioMedSci(Hons) (Monash) (until February) Rosenberg M, BSc(Hons) (Canterbury) Kim J-H, BSc Fung S Arsov T, MD (St Cirilus and Methodius), MS (St Cirilus Sakala I, BMedSc (Zambia) and Methodius) Kuo IY, BSc (UWA) Gasparini C Sammut R, BAppSc (Monash), BEc (Monash) Brown K, BSc(Hons) (Murdoch) Lim C, BSc(Hons) Guo LJ Scott B, BSc, PGDip (UQ) Calanni S, BSc(MedSci) (USyd), BSc(Hons) Lindsay H, BMathSci (Newcastle) Hynes K Seymour V, BSc(Hons) (Otago) Chakka N, BDS (Bangalore) MSc (Bioinformatics) Linterman MA, BBMEDS (Victoria) Johnstone K Sheahan D, BSc(Hons) (from February) (East Anglia) Manker A, BSc (Deakin) Kanjanapan Y Shen Te H, BSc(Hons) (Malaysia) Corley S, BLaw (UQ), MLaw, BSc(Hons) (USyd) Maritz A, BMedSci, MBA (Rochester), PhD (Rochester) Kwa AA Simpson N, MBBS (USyd), MPH (UNSW) (from January) Correcha M, MBBS (Cauca) (January - July) Lawless K Singhal S, BSc(Hons) (Delhi), MSc(BioTech) (Panjab) Day S, BBioTech(Hons) Pang M, BSc (Adel) Lee L Sjollema G, BSc De Mestre A, BVSc(Hons) (USyd) (until June) Scott PC, BSc Liew WC Socha LH, MD (Colombian National) GradCertClinicalTrials Eichner D, BSc(Hons) (until November) Siggs OM, BSc (Adel), DipLang (Adel) Lim C Management (UC) Ellis L, BAppSci (UC) Sivalingam I, BSc (Singapore) Lindsay H Soe-Htwe T, BA (Cornell) Ellyard J, BAs, BSc(Hons) Subramaniam AS, BSc Linterman M Sontani Y, BSc (Murdoch) (from March) Everitt A, BSc Sutherland D, BSc Nandapalan N Storer J, BBioTech(Hons) (Wollongong) (from February) Farnsworth M, BSc (Wollongong), BSc(Hons) Thomas AJ, BSc Neilson J Sutcliffe E, BSc (NTU), (Hons) Flening E, BSc(Hons) (UNSW) Walker AA, BSc Pang M Svahn K, BSc, MSc (Gothenburg) Harley N, BSc(Hons) Park T Taylor M, BSc, MPhil International Scholars Harrison J, BSc(Biomed Sci)(Hons) (Adel) (until November) Rosenberg M Wei L Crecca C, BSc (Bloomsburg) He Y-Q, MSc (Sun Yat-Sen) (from March) Scolaro L Weiss SB, AppSc, PhD, M FinMgt De Melo Naves M Hill K, BMed&AppBiotech(Hons) (CSU) (until August) Hu L Sharma A Wood R, BSc(Hons) (JCU) Hyun Y-M, BSc, MSc (Yonsei) (until Sept) Salomäki M Sutherland D Wu, Z, MSc (UNSW), BM (ZhongShan) Yuchun M Ikeda K, BA (UC Boulder) Tan C Yamada T Leao R, BSc, MD (UFU) Tan EJ Youssoufi an M, BSc (California), BSc(Hons) Leffl er M, BMedSci(Hons) (MacqU) (from March) Thomas A Yu D, BSc (Wuhan) Letzkus J, DipBiol (Mainz) Williams H Zhang J, BMSc, (Hunan) Lim C, BTech(Hons) (Auckland) Woodall H Zhou, J, MD (Guang Xi) Liston A, BSc(Hons) (Adel) (until January) Ziolkowski A, BSc(Hons) McCuaig R, BSc (UC), GradDipSciMolBiol, BSc(Hons) (UTas) Miao Y, BMed (China) MPhil Scholars Morris M, BMedsci(Hons) (JCU) Bowman E, BSc(Hons) Murase T, BSc(Hons) Navarro-Gonzales M, BVSc (Caldas) Ng E, BMedSc(Hons) (from February) O’Rance L, BMedSci(Hons) (USyd)

56 57 57 School Administration & Services Staff 2005 Staff 2005

School Administration School Services School Services

School Administration School Services Biomolecular Resource Facility (BRF) Howard Florey Professor of Medical Research Animal Services Manager Senior Storeperson Edwards K, BSc (Natal), BSc(Hons) (Cape Town), PhD Clements R and Director Head (University College Lond), GradCert Tertiary Teaching Whitworth JA, AC, DSc, MD, PhD, BS (UMelb), MD Reid A, MIAT (UK), HNC Biological Sciences Storeperson (Honoris causa) (USyd), MD (Honoris causa) (UNSW) (JCU), MEnvMng (UNE) Daniel-Marsh D Deputy Head FRACP, FAICD Technical Specialist Metcalfe C, Cert Vet Nursing, Cert Frontline Management General Services Deputy Director Milburn P, BSc(Hons), PhD (Sheffield) Office Administration Redman SJ, ME (UNSW), PhD (Monash), DSc Microarray Coordinator Head Hargrave T (Monash) FAA Peng K, PhD (Wuhan) Elsbury S, BAppSc, GradDipMedLabTech Khan P (part-time) Business Manager Bioinformatics Analyst Security Divisional Veterinarian Webb B, AdvDipBusMan (CIT) Ohms S, MBChB, ME, PhD (Auckland) Barancewicz D (casual) Bain SAF, BVSc (USyd), MACVSc (part-time) Blinksell P School Visitor DNA sequencing Senior Technical Officers Carter I (until March) Fenner Emeritus Professor F, AC, CMG, MBE, FRS, FAA, McCrae C, BiolTech Cert (CIT) Gooding D Ciuffetelli L MD, DTM, Hon Md, Dr honoris causa (Liege), FRACP, Richardson J Peptide Synthesis Lazarov Z FRCP (Lond) McAndrew K, AssDipAppSci (UC) Technical Officers Simpkin W Convenor, Graduate Program in Medical Burke H Tetramer Synthesis Williams F (casual) Sciences Comans C Sutherland T, BappSci (CSU) Cleaners Ross V, BA, BLitt, PhD Faucett T Administrative Assistant Belling N Public Affairs Officer Porritt T Moore S Bourke P Nicol MJ, BSc (Wollongong), BSc(Hons), PhD Sutton M Bourke R (casual) Media/Wash-Up Section Safety & Training Officer Animal Technicians Grant D Cregan A, BSc Barancewicz N (part-time) Manager Hatton M (casual) Woodhams CE, BAppSc (CCAE), GradDipInfSyst (UC) Executive Assistant to Director Bowes V (from January) Hayden C (until August) Jacobsen AJ, Cert Frontline Management Burke B Technicians Kim J (until September) McVey S Administrative Assistants Cox S Carpenter J (casual from May) Dutton K White N Arnold J (until November) Gilmartin L, Lab Skills Cert 3 (CIT) Figueroa F (from April) Williams F (casual) Morales D Munday K (from May) Figueroa S Williams J (casual) Priest K (from November) Thileebhan S Fook N Tompsett S, BAppSc (UC) (January – May) Martin J Human Resources Smyth V (from June) Finance and Research Support Head Tulsiani S (part-time) Finance Manager Browning KO Ware D (until April) Sawyer V HR Officers Williams N (from January) Senior Finance Officer Cornwell H Material Support Technicians Sinnott T Hayden AM Cover G Finance Officers HR Assistant Officer Forgie I Cairns C (part-time until November) Smith BA Hamilton R Cousins M Hogan P Talbot M Jarvis L Senior Purchasing Officer Santrac C Hicks G Sparrow M (from August) Violante O Purchasing Officers Allan N Young S (part-time) Lavender S Tracey E (until November)

58 59 Staff 2005

School Services

Information Technology & Technical Services Communications Unit (ITCU) Head Head Coombes D Publications Collis A, BIT, BE(Hons) Deputy Head Network Manager Emans P Zhang Q, BComputerSci (Beijing), MBA Technical Officers Programmer Best N During 2005, staff and students of The John Curtin School Commons R Cole P published invited reviews, book chapters, and peer reviewed Cremer P Multimedia articles in scientific journals. Edwards K, Phot Cert Ellison J Hosking A (until November) Fenning M, Phot Cert, AAIPP A full list appears on the following pages. Macklin J, Phot Cert Jakubaszek R Jordan T Client Support Team Leader Kelly D Henderson S, Teach Cert (Lond) Keys B Client Support Lang P Hodgkins D (from March) Percival M McCulloch A Rhall G Reed A, BComm(Hons) (until March) Robertson A Sime D, Electronics Cert Symons C Microscopy and Cytometry Resource Administrative Assistant Facility (MCRF) McGann J Apprentices Head Backhouse B Gillespie CM Gair L Senior Technical Officer – Microscopy Unit McCart RJ, BA (UMelb), BSc(Hons) (UWA) Senior Technical Officer – Histology Unit Prins AS, BAppSci (RMIT) Senior Technical Officers – Flow Cytometry Unit Grüninger S (until September) Vohra H, MSc(Hons) (Punjab), PhD (PGIMER) (from January) Willhoite, A

The John Curtin School of Medical Research Annual Review 2005

60 Publications 2005

Publications 2005 JCSMR Publications JCSMR Publications

Abbott, CL, Double, MC, Trueman, JWH, Robinson, Booth, HS, Burden, CJ, Maindonald, JH, Santosa, L, De Rose, R, Chea, S, Dale, CJ, Reece, J, Fernandez, Edwards, FR and Hirst, GDS (2005) An electrical A, and Cockburn, A (2005) An unusual source of Wakefield, MJ, and Wilson, SR (2005) Discussion CS, Wilson, KM, Thomson, S, Ramshaw, IA, description of the generation of slow waves in the apparent mitochondrial heteroplasmy: duplicate of “A Bayesian Approach to DNA Sequence Coupar, BEH, Boyle, DB, Sullivan, MT, and Kent, SJ antrum of the guinea-pig. Journal of Physiology- mitochondrial control regions in Thalassarche Segmentation”. Biometrics 61(635-637). (2005) Subtype AE HIV-1 DNA and recombinant London 564(1): 213-232. albatrosses. Molecular Ecology 14(11): 3605-3613. Brettingham-Moore, KH, Rao, S, Juelich, T, Shannon, Fowlpoxvirus vaccines encoding five shared HIV- Fang, Y (2005) The Mathematical Protein Folding Ada, G (2005) Overview of vaccines and vaccination MF, and Holloway, AF (2005) GM-CSF promoter 1 genes: safety and T cell immunogenicity in Problem. “Global Theory of Minimal Surfaces” - 2004. Molecular Biotechnology 29(3): 255-272. chromatin remodelling and gene transcription macaques. Vaccine 23(16): 1949-1956. Clay Mathematical Proceedings 2: 611-622. Alonso, H, Gillies, MB, Cummins, PL, Bliznyuk, AA, display distinct signal and transcription factor Doan, T, Herd, K, Ramshaw, I, Thomson, S, and Tindle, Fenner, F (2005) The Australian Academy of Science: The and Gready, JE (2005) Multiple ligand-binding requirements. Nucleic Acids Research 33(1): 225-34. RW (2005) A polytope DNA vaccine elicits multiple First Fifty Years. modes in bacterial R67 dihydrofolate reductase. Bruce, K, Myers, FA, Mantouvalou, E, Lefevre, P, effector and memory CTL responses and protects against human papillomavirus 16 E7-expressing Ferry, H, Cockford, TL, Silver, K, Rust, N, Goodnow, Journal of Computed Aided Molecular Design 19(3): Greaves, I, Bonifer, C, Tremethick, DJ, Thorne, AW, CC, and Cornall, RJ (2005) Analysis of Lyn/CD22 tumour. Cancer Immunology Immunotherapy 54(2): 165-87. and Crane-Robinson, C (2005) The replacement double-deficient B cells in vivo demonstrates Lyn- 157-171. Alsharifi, M, Lobigs, M, Regner, M, Lee, E, Koskinen, histone H2A.Z in a hyperacetylated form is a and CD22-independent pathways affecting BCR A, and Müllbacher, A (2005) Type I interferons feature of active genes in the chicken. Nucleic Dulhunty, AF, Cengia, L, Young, J, Pace, SM, Harvey, regulation and B cell survival. European Journal of trigger systemic, partial lymphocyte activation in Acids Research 33(17): 5633-5639. PJ, Lamb, GD, Chan, YN, Wimmer, N, Toth, I, and Immunology 35(12): 3655-3663. response to viral infection. Journal of Immunology Chakravarthy, S, Bao, Y, Roberts, VA, Tremethick, D, Casarotto, MG (2005) Functional implications of modifying RyR-activating peptides for membrane Franklin, A and Blanden, RV (2005) Hypothesis: A 175: 4635-4640. and Luger, K (2005) Structural characterization of biological role for J-C intronic matrix attachment permeability. British Journal of Pharmacology Aubrey, KR, Vandenberg, RJ, and Clements, JD (2005) histone H2A variants. Cold Spring Harbor Symposia regions in the molecular mechanism of antigen- 144(6): 743-754. Dynamics of forward and reverse transport by on Quantitative Biology 2004 69: 227-234. driven somatic hypermutation. Immunology and Cell the glial glycine transporter, Glyt1b. Biophysical Chea, S, Dale, CJ, De Rose, R, Ramshaw, IA, and Kent, Dulhunty, AF, Karunasekara, Y, Curtis, SM, Harvey, Biology 83(4): 383-391. PJ, Board, PG, and Casarotto, MG (2005) The Journal 89(3): 1657-1668. SJ (2005) Enhanced cellular immunity in macaques Franklin, A and Blanden, RV (2005) Somatic following a novel peptide immunotherapy. Journal recombinant dihydropyridine receptor II-III loop Baker, RT, Catanzariti, AM, Karunasekara, Y, Soboleva, and partly structured ‘C’ region peptides modify hypermutation at A·T pairs: critical analysis of TA, Sharwood, R, Whitney, S, and Board, PG (2005) of Virology 79(6): 3748-3757. the dUTP-incorporation model. Nature Review cardiac ryanodine receptor activity. Biochemical Using deubiquitylating enzymes as research tools. Chen, X, Wang, J, Woltring, D, Gerondakis, S, and Immunology eFirst. Journal 385: 803-813. Methods in Enzymology 398: 540-554. Shannon, MF (2005) Histone dynamics on the Dulhunty, AF, Karunasekara, Y, Curtis, SM, Harvey, PJ, Freeman, C, Liu, LG, Banwell, MG, Brown, KJ, Bezos, Beard, NA, Casarotto, MG, Wei, L, Varsanyi, M, interleukin-2 gene in response to T-Cell Activation. A, Ferro, V, and Parish, CR (2005) Use of sulfated Molecular and Cellular Biology 25(8): 3209-3219. Board, PG, and Casarotto, MG (2005) Role of some Laver, DR, and Dulhunty, AF (2005) Regulation unconserved residues in the “C” region of the linked cyclitols as heparan sulfate mimetics to probe of ryanodine receptors by calsequestrin: Effect Cui, YF, Karunasekara, Y, Harvey, PJ, Board, PG, the heparin/heparan sulfate binding specificity of skeletal DHPR II-III loop. Frontiers of Bioscience of high luminal Ca2+ and phosphorylation. Dulhunty, AF, and Casarotto, MG (2005) Letter proteins. Journal of Biological Chemistry 280(10): 10: 1368-81. Biophysical Journal 88(5): 3444-3454. to the editor: H-1, N-13 and N-15 assignments 8842-8849. for the II-III loop region of the skeletal Dulhunty, AF, Pouliquin, P, Coggan, M, Gage, PW, Bekkers, JM (2005) Presynaptically silent GABA and Board, PG (2005) A recently identified Frugier, T, Koishi, K, Matthaei , KI, and McLennan, IS synapses in hippocampus. Journal of Neuroscience dyhydropyridine receptor. Journal of Biomolecular (2005) Transgenic mice carrying a tetracycline- NMR 32(1): 89-90. member of the glutathione transferase structural 25(16): 4031-4039. family modifies cardiac RyR2 substate activity, inducible, truncated transforming growth factor Blink, EJ, Zhou, JS, Hu, W, Calanni, ST, Trapani, Cummins, PL and Gready, JE (2005) Computational coupled gating and activation by Ca2+ and ATP. beta receptor (TbetaRII). Genesis 42(1): 1-5. methods for the study of enzymic reaction JA, Bird, PI, and Jans, DA (2005) Interaction of Biochemical Journal 390(1): 333-343. Gage, PW, Ewart, G, Melton, J, and Premkumar, A the nuclear localizing cytolytic granule serine mechanisms III: a perturbation plus QM/MM Easteal, S, Whittle, B, Mettenmeyer, A, Attenborough, (2005) Virus ion channels formed by Vpu of HIV-1, protease granzyme B with importin alpha or beta: approach for calculating relative free energies of the 6K protein of Alphaviruses and NB of influenza R, Bhatia, K, and Alpers, MP, 2005, Mitochondrial Modulation by the serpin inhibitor PI-9. Journal of protonation. Journal of Computational Chemistry B virus. Viral membrane proteins: Structure, Function, 26(6): 561-568. genome diversity among Papuan-speaking people Cellular Biochemistry 95(3): 598-610. of Papua New Guinea. 1st ed. Papuan pasts: and Drug Design 1: 207-231. Board, PG and Anders, MW (2005) Human de Mestre, AM, Rao, S, Hornby, JR, Soe-Htwe, T, Cultural, linguistic and biological histories of Goodnow, CC, Sprent, J, De St Groth, BF, and Vinuesa, glutathione transferase zeta. Methods in Khachigian, LM, and Hulett, MD (2005) EGR1 Papuan-speaking peoples, eds. R.A. Andrew CG (2005) Cellular and genetic mechanisms of self Enzymology 401: 67-77. regulates heparanase transcription in tumour cells. Pawley, Jack Golson and Robin Hide, Canberra: tolerance and autoimmunity. Nature 435: 590-597. Journal of Biological Chemistry 280(42): 35136- Pacific Linguistics, Australian National University. Board, PG, Anders, MW, and Blackburn, AC (2005) 35147. Catalytic Function and Expression of Glutathione pp. 717-728. Transferase Zeta. 1st ed. Drug Metabolism and Transport, eds. LH Lash, USA: Humana Press Inc, pp. 85-107. 62 63 Publications 2005

Publications 2005 JCSMR Publications JCSMR Publications

Gready, JE, (2005) Defining the inefficiencies in Hu, KF, Regner, M, Siegrist, CA, Lambert, P, Kent, SJ, Dale, CJ, Ranasinghe, C, Stratov, I, De Rose, Liston, A, Lesage, S, Gray, DHD, Boyd, RL, and the chemical mechanism of the photosynthetic Chen, M, Bengtsson, KL, and Morein (2005) R, Chea, S, Montefiori, DC, Thomson, S, Ramshaw, Goodnow, CC (2005) Genetic lesions in T-cell enzyme Rubisco by computational simulation. The immunomodulating properties of human IA, Coupar, BE, Boyle, DB, Law, M, Wilson, KM, tolerance and thresholds for autoimmunity. Artificial Photosynthesis, eds. A. Collings and C. respiratory syncytial virus and immunostimulating and Ramsay, AJ (2005) Mucosally-administered Immunological Reviews 204: 87-101. Critchley: Wiley-VCH, Weinheim. pp. 263-282. complexes containing Quillaja saponin human-simian immunodeficiency virus DNA Lobigs, M and Lee, E (2005) Coordination of Gulledge, AT, Kampa, BM, and Stuart, GJ (2005) components QH-A, QH-C and ISCOPREPTM703. and fowlpoxvirus-based recombinant vaccines cleavages at the flavivirus C-PRM junction: Role in Synaptic integration in dendritic trees. Journal of FEMS Immunol. Med. Mic. 43(269-276). reduce acute phase viral replication in macaques virus assembly and virulence. Arbovirus Research in Neurobiology 64(1): 75-90. Hu, W, Kemp, BE, and Jans, DA (2005) Kinetic following vaginal challenge with CCR5-tropic Australia 9: 202-206. SHIV(SF162P3). Vaccine 23(42): 5009-5021. Gulledge, AT and Stuart, GJ (2005) Cholinergic properties of nuclear transport conferred by Luu, T, Cromer, B, Gage, PW, and Tierney, ML inhibition of neocortical pyramidal neurons. the retinoblastoma (Rb) NLS. Journal of Cellular Kimura, T, Nakamori, M, Lueck, JD, Pouliquin, P, (2005) A role for the 2‘ residue in the second Journal of Neuroscience 25: 10308-20. Biochemistry 95(4): 782-793. Aoike, F, Fujimura, H, Dirksen, RT, Takahashi, MP, transmembrane helix of the GABA(A) receptor Dulhunty, AF, and Sakoda, S (2005) Altered mRNA Haarmann, CS, Dulhunty, AF, and Laver, DR (2005) Jarvinen, JLP and Lamb, TD (2005) Inverted gamma 2S subunit in channel conductance and photocurrent responses from amphibian rod photo splicing of the skeletal muscle ryanodine receptor gating. Journal of Membrane Biology 205(1): 17-28. Regulation of skeletal ryanodine receptors by and sarcoplasmic/endoplasmic reticulum Ca2+- dihydropyridine receptor II-III loop C-region receptors: role of membrane voltage in response Maddess, T, James, AC, and Bowman, EA (2005) ATPase in myotonic dystrophy type 1. Human peptides: relief of Mg2+. Journal of Biochemistry recovery. Journal of Physiology-London 566(2): Contrast response of temporally sparse dichoptic Molecular Genetics 14(15): 2189-2200. 387(2): 429-436. 455-466. multifocal visual evoked potentials. Visual Leao, RN, Leao, FN, and Walmsley, B (2005) Non- Haddock, RE and Hill, CE (2005) Rhythmicity in Jones, AL, Hulett, MD, and Parish, CR (2005) Neuroscience 22(2): 153-162. Histidine-rich glycoprotein: A novel adaptor random nature of spontaneous mIPSCs in mouse arterial smooth muscle. Journal of Physiology- auditory brainstem neurons revealed by recurrence Mannervik, B, Board, PG, Hayes, JD, Listowsky, I, and London 566(3): 645-656. protein in plasma that modulates the immune, Pearson, WR (2005) Nomenclature for Mammalian vascular and coagulation systems. Immunology and quantification analysis. Proceedings of the Royal Hamer, RD, Nicholas, SC, Tranchina, D, Lamb, TD, soluble glutathione transferases. Methods Cell Biology 83(2): 106-118. Society B-Biological Sciences-London 272(1580): and Jarvinen, JLP (2005) Towards a unified model 2551-2559. in Enzymology, eds. H Sies and LPacker. 401, of vertebrate rod phototransduction. Visual Jones, AL, Poon, IKH, Hulett, MD, and Parish, CR California: Elsevier. pp. 1-8. (2005) Histidine-rich glycoprotein specifically Leao, RN, Svahn, K, Berntson, A, and Walmsley, B Neuroscience 22: 417-436. (2005) Hyperpolarization-activated (I) currents Martin, P, Wallich, R, Pardo, J, Müllbacher, A, binds to necrotic cells via its amino-terminal Modolell, M, and Simon, MM (2005) Quiescent Harley, N, Attenborough, R, Alpers, MP, Mgone, C, domain and facilitates necrotic cell phagocytosis. in auditory brainstem neurons of normal and Bhatia, K, and Easteal, S, 2005, The importance and activated mouse granulocytes do not express Journal of Biological Chemistry 280(42): 35733- congenitally deaf mice. European Journal of of social structure for patterns of human genetic granzyme A and B or perforin: similarities or 35741. Neuroscience 22(1): 147-57. diversity: Y-chromosome and mitochondrial differences with human polymorphonuclear Levidiotis, V, Freeman, C, Tikellis, C, Cooper, ME, and genome variation in Papuan speaking people Joyce, JA, Freeman, C, Meyer-Morse, N, Parish, CR, leukocytes? Blood 106(8): 2871-2878. Power, DA (2005) Heparanase inhibition reduces of mainland Papua New Guinea. 1st ed. Papuan and Hanahan, D (2005) A functional heparan proteinuria in a model of accelerated anti- Martin, RE, Henry, RI, Abbey, JL, Clements, JD, and pasts: Cultural, linguistic and biological histories sulfate mimetic implicates both heparanase glomerular basement membrane antibody disease. Kirk, K (2005) The ‘permeome’ of the malaria of Papuan-speaking peoples, eds. R.A. Andrew and heparan sulfate in tumor angiogenesis and parasite: an overview of the membrane transport Nephrology 10: 167-173. Pawley, Jack Golson and Robin Hide, Canberra: invasion in a mouse model of multistage cancer. proteins of Plasmodium falciparum. Genome Pacific Linguistics, Australian National University. Oncogene 24(25): 4037-4051. Lie, K, Press, C, McCullagh, P, McClure, S, and Biology 6(3): Art No. R26. Landsverk, T (2005) Differentiation of the follicle- pp. 729-756. Kampa, BM and Stuart, GJ (2005) NMDA receptor May, FJ, Lee, E, Lobigs, M, Mackenzie, JS, and Hall, kinetics are tuned for coincidence detection associated epithelium in ileal Peyer’ s patch and Hashitani, H, Garcia-Londono, AP, Hirst, GDS, and production of 50-nm particles are maintained RA (2005) Genetic, antigenic and biological Edwards, FR (2005) Atypical slow waves generated during spike-timing dependent synaptic plasticity. characterisation of alfuy virus. Arbovirus Research in B-cell-depleted fetal sheep. Cell and Tissue in gastric corpus provide dominant pacemaker Physiological News 58: 29-30. in Australia 9: 207-210. Research 319(3): 395-404. activity in guinea pig stomach. Journal of Kenkre, JS, Moran, NA, Lamb, TD, and Mahroo, OAR Linterman, M and Vinuesa, CG (2005) Roquin: a novel McLennan, IS, Welble, MW, Hendry, IA, and Koishi, Physiology-London 569(2): 459-465. (2005) Extremely rapid recovery of human cone K (2005) Transport of transforming growth circulating current at the extinction of bleaching immune regulator that represses ICS expression Henderson, S (2005) The Neglect of Volition. Journal and differentiation of self-reactive T cells. factor-beta 2 across the blood-brain barrier. of Psychiatry 186: 273-274. exposures. Journal of Physiology-London 567: 95-112. Neuropharmacology 48(2): 274-282. Inmunologia 24: 326-333. Liston, A and Goodnow, CC (2005) Genetic lesions Miosge, L and Goodnow, CC (2005) Genes, pathways in thymic T cell clonal deletion and thresholds for and checkpoints in lymphocyte development and homeostasis. Immunology and Cell Biology 83(4): autoimmunity. Genetics of Autoimmunity, eds. G Bock and J Goode, Chichester, UK: John Wiley and 318-335. Sons Ltd pp. 180-199. 64 65 Publications 2005

Publications 2005 JCSMR Publications JCSMR Publications

Oleskevich, S, Leck, KJ, Matthaei, K, and Hendry, Premkumar, A, Horan, CR, and Gage, PW (2005) Schmuck, EM, Board, PG, Whitbread, AK, Technau, U, Rudd, S, Maxwell, P, Gordon, PMK, Saina, IA (2005) Enhanced serotonin response in the Dengue virus M protein C-terminal peptide Tetlow, N, Cavanaugh, JA, Blackburn, AC, M, Grasso, LC, Hayward, DC, Sensen, CW, Saint, hippocampus of G alpha z protein knock-out mice. (DVM-C) forms ion channels. Journal of Membrane and Masoumi, A (2005) Characterization R, Holstein, TW, Ball, EE, and Miller, DJ (2005) Neuroreport 16(9): 921-925. Biology 204(1): 33-38. of the monomethylarsonate reductase and Maintenance of ancestral complexity and non- Pamungkas, J, De Rose, R, Iskandriati, D, Noviana, R, Premzl, M, Delbridge, M, Gready, JE, Wilson, P, dehydroascorbate reductase activities of metazoan genes in two basal cnidarians. Trends in Paramastri, Y, Dale, CJ, Shoobridge, M, Medveczky, Johnson, M, Davis, J, Kuczek, E, and Graves, Omega class glutathione transferase variants: Genetics 21(12): 633-639. CJ, Ramshaw, IA, Thomson, S, and Kent, SJ (2005) JAM (2005) The prion protein gene: Identifying implications for arsenic metabolism and the age- Thomson, SA, Jaramillo, AB, Shoobridge, M, Dunstan, Comparison of whole gene and whole virus regulatory signals using marsupial sequence. Gene at-onset of Alzheimer’s and Parkinson’s diseases. KJ, Everett, B, Ranasinghe, C, Kent, SJ, Gao, K, scrambled antigen approaches for DNA prime 349: 121-134. Pharmacogenetics and Genomics 15(7): 493-501. Medveckzy, J, Ffrench, RA, and Ramshaw, IA (2005) and fowlpox virus boost HIV type 1 vaccine Prescott, VE, Campbell, PM, Moore, A, Mattes, J, Shannon, MF, McKenzie, KUS, Edgley, A, Rao, S, Development of a synthetic consensus sequence regimens in macaques. AIDS Research and Human Rothenberg, ME, Foster, PS, Higgins, TJ, and Peng, K, Shweta, A, Schyvens, CG, Anderson, WP, scrambled antigen HIV-1 vaccine designed for Retroviruses 21(4): 292-300. Hogan, SP (2005) Transgenic Expression of Wilson, SR, Pittelkow, YE, Ohms, S, and Whitworth, global use. Vaccine 23(38): 4647-4657. Panchanathan, V, Chaudhri, G, and Karupiah, G Bean alpha-Amylase Inhibitor in Peas Results in JA (2005) Optimizing microarray in experimental Tscharke, DC, Karupiah, G, Zhou, J, Palmore, T, Irvine, (2005) Interferon function is not required for Altered Structure and Immunogenicity. Journal of hypertension. Kidney International 67(1): 364-370. KR, Haeryfar, SMM, Williams, S, Sidney, J, Sette, A, recovery from a secondary poxvirus infection. Agriculture and Food Chemistry 53(23): 9023-9030. Simeonovic, CJ, Ziolkowski, AF, Popp, SK, Milburn, Bennink, JR, and Yewdell, JW (2005) Identification Proceedings of the National Academy of Sciences of Reynolds, AJ, Kaasinen, SK, and Hendry, IA (2005) PJ, Lynch, CA, Hamilton, P, Harris, K, Brown, DJ, of poxvirus CD8(+) T cell determinants to enable the USA 102(36): 12921-12926. Retrograde axonal transport of dopamine Bain, SAF, Wilson, JD, and Gibbs, AJ (2005) Porcine rational design and characterization of smallpox Pao, L, Sumaria, N, Kelly, JL, van Dommelen, S, beta hydroxylase antibodies by neurons in the endogenous retrovirus encodes xenoantigens vaccines. Journal of Experimental Medicine 201(1): Cretney, E, Wallace, ME, Anthony, DA, Uldrich, trigeminal ganglion. Neurochemical Research involved in porcine cellular xenograft rejection by 95-104. AP, Godfrey, DI, Papadimitriou, JM, Müllbacher, 30(6/7): 703-712. mice. Transplantation 79(12): 1674-1682. van den Buuse, M, Martin, S, Brosda, J, Leck, KJ, A, Degli-Esposti, MA, and Smyth, MJ (2005) Robbins, SJ, Jackson, RJ, Fenner, F, Beaton, S, Soboleva, TA, Jans, DA, Johnson-Saliba, M, and Baker, Matthaei, KI, and Hendry, IA (2005) Enhanced Functional Analysis of Granzyme M and Its Role Medveczky, J, Ramshaw, IA, and Ramsay, AJ RT (2005) Nuclear-cytoplasmic shuttling of the effect of dopaminergic stimulation on prepulse in Immunity to Infection. Journal of Immunology (2005) The efficacy of cidofovir treatment of oncogenic mouse UNP/USP4 deubiquitylating inhibition in mice deficient in the alpha subunit of 175(5): 3235-3243. mice infected with ectromelia (mousepox) virus enzyme. Journal of Biological Chemistry 280(1): G(z). Psychopharmacology 183(3): 358-367. Papathanasiou, P and Goodnow, CC (2005) encoding interleukin-4. Antiviral Research 66(1): 745-752. van der Klift, H, Wijnen, J, Wagner, A, Verkuilen, P, Connecting Mammalian Genome with Phenome 1-7. Solomon, MF, Ramshaw, IA, and Simeonovic, Tops, C, Otway, R, Kohonen-Corish, M, Vasen, H, by ENU Mouse Mutagenesis: Gene Combinations Rosen, DB, Bettadapura, J, Alsharifi, M, Mathew, CJ (2005) Recombinant fowlpox virus for in Oliani, C, Barana, D, Moller, P, DeLozier-Blanchet, Specifying the Immune System. Annual Review of PA, Warren, HS, and Lanier, LL (2005) Cutting vitro gene delivery to pancreatic islet tissue. C, Hutter, P, Foulkes, W, Lynch, H, Burn, J, Moslein, Genetics 39: 241-262. Edge: Lectin-like transcript 1 is a ligand for the Immunology and Cell Biology 83(6): 615-625. G, and Fodde, R (2005) Molecular characterization Parish, CR (2005) Heparan sulfate and inflammation. inhibitory human NKR-P1A receptor. Journal of Staykova, MA, Paridaen, JT, Cowden, WB, and of the spectrum of genomic deletions in the Nature Immunology 6(9): 861-862. Immunology 176: 7796-7799. Willenborg, DO (2005) Nitric oxide contributes mismatch repair genes MSH2, MLH1, MSH6, and PMS2 responsible for hereditary Nonpolyposis Peters, KE, O’Callaghan, NJ, and Cavanaugh, Rummery, NM, Grayson, TH, and Hill, CE (2005) to resistance of the Brown Norway rat to colorectal cancer (HNPCC). Genes, Chromosomes JA (2005) Lack of association of the CD14 Angiotensin-converting enzyme inhibition restores experimental autoimmune encephalomyelitis. and Cancer 44(2): 123-138. promoter polymorphism-159C/T with Caucasian endothelial but not medial connexin expression in American Journal of Pathology 166(1): 147-157. inflammatory bowel disease. Scandinavian Journal hypertensive rats. Journal of Hypertension 23(2): Sunn, KL, Eisman, JA, Gardiner, EM, and Jans, DA Vinuesa, CG, Cook, MC, Angelucci, C, Athanasopoulos, of Gastroenterology 40(2): 194-197. 317-328. (2005) FRAP analysis of nucleocytoplasmic V, Rui, L, Hill, KM, Y, Yu, D, Domaschenz, H, Whittle, B, Lambe, T, Roberts, IS, Copley, IR, Bell, JI, Potter, SM, Mitchell, AJ, Cowden, WB, Sanni, LA, Santosa, L, Booth, HS, Burden, CJ, and Hegland, dynamics of the vitamin D receptor splice variant VDRB1: preferential targeting to nuclear speckles. Cornall, RJ, and Goodnow, CC (2005) A RING-type Dinauer, M, de Haan, JB, and Hunt, NH (2005) M (2005) A stochastic model of gene switches. ubiquitin ligase family member essential to repress Phagocyte-derived reactive oxygen species do not ANZIAM Journal 46: C530-43. Biochemical Journal 388: 509-514. follicular helper T cells and autoimmunity. Nature influence the progression of murine blood-stage Sylantyev, SO, Lee, C, and Shyu, B (2005) A 435(452-458). malaria infections. Infection and Immunity 73(8): parametric assessment of GABA antagonist effects 4941-4947. on paired-pulse facilitation in the rat anterior Vinuesa, CG, Tangye, SG, Moser, B, and Mackay, CR (2005) Follicular B Helper T Cells in antibody Power, JM and Sah, P (2005) Intracellular calcium cingulate cortex. Neuroscience Research 52(4): responses and autoimmunity. Nature Reviews store filling by an L-type calcium current in the 362-370. Immunology 5: 853-865. basolateral amygdala at subthreshold membrane potentials. Journal of Physiology 562(2): 439-453.

66 67 Publications 2005 JCSMR Publications

Wakefield, MJ and Graves, JAM (2005) Marsupials Williamson, PM, Kohlhagen, JL, Mangos, GJ, and monotremes sort genome treasures from junk. Whitworth, JA, and Kelly, JJ (2005) Acute effects Genome Biology 6: 218. of hydrocortisone on plasma nitrate/nitrite Wakefield, MJ, Maxwell, P, and Huttley, GA (2005) activity and forearm vasodilator responsiveness in Contact with our Community Vestige: maximum likelihood phylogenetic normal human subjects. Clinical and Experimental footprinting. BMC Bioinformatics 6: 130. Pharmacology and Physiology 32(3): 162-166. Warren, H (2005) The Eighth Leucocyte Williamson, PM, Tam, SH, Kelly, JJ, and Whitworth, Differentiation Antigen (HLDA8) Workshop: JA (2005) Ganglion blockade does not prevent The John Curtin School of Medical Research is committed to Natural Killer (NK) cell section report. Cellular cortisol-induced hypertension in man. Clinical and maintaining contact with our past staff and students through Immunology 236: 17-20. Experimental Pharmacology and Physiology 32(4): our Alumni and Friends network. 294-296. Warren, HS and Bettadapura, J (2005) A novel We strive to strengthen our ties with our local Canberra binding assay to assess specificity of monoclonal Youssoufian, MR, Oleskevich, S, and Walmsley, B community through visits and speaking engagements. antibodies. Journal of Immunological Methods. (2005) Development of a robust central auditory For information about joining this growing network of friends synapse in congenital deafness. Journal of 305(1): 33-38. and supporters, please contact our Public Affairs Manager, Neurophysiology 94(5): 3168-3180. Warren, HS, Jones, AL, Freeman, C, Bettadapura, Dr Madeleine Nicol J, and Parish, CR (2005) Evidence That the Zelensky, AN and Gready, JE (2005) The C-type T: +61 2 6125 2577 F: +61 2 6125 2337 lectin-like domain superfamily. FEBS Journal Cellular Ligand for the Human NK Cell Activation E: [email protected] Receptor NKp30 Is Not a Heparan Sulfate 272(24): 6179-6217. Glycosaminoglycan. Journal of Immunology 175(1): Zhang, J and Hill, CE (2005) Differential connexin 207-12. expression in preglomerular and postglomerular Wenzel, A, Oberhauser, V, Pugh, ENJ, Lamb, vasculature: Accentuation during diabetes. Kidney TD, Grimm, C, Samardzija, M, Seeliger, MW, International 68(3): 1171-1185. Remé, CE, and von Lintig, J (2005) The retinal Zhang, Y, Chan, MMK, Andrews, MC, Mori, TA, Croft, G protein-coupled receptor (RGR) enhances KD, McKenzie, KUS, Schyvens, CG, and Whitworth, isomerohydrolase activity independent of light. JA (2005) Apocynin but not allopurinol prevents Journal of Biological Chemistry 280(33): 29874- and reverses ACTH-induced hypertension in the 29884. rat. American Journal of Hypertension 18: 910-916. Whitbread, AK, Masoumi, A, Tetlow, N, Schmuck, E, Zhu, HL, Hirst, GDS, Ito, Y, and Teramoto, N (2005) Coggan, M, and Board, PG (2005) Characterization Modulation of voltage-dependent Ba2+ currents of the omega class of glutathione transferases. in the guinea-pig gastric antrum by cyclic Methods in Enzymology 401:78-99. nucleotide-dependent pathways. British Journal of Whitworth, JA (2005) Progression of renal failure Pharmacology 146(1): 129-138. - the role of hypertension. Annals Academy of Ziskind-Conhaim, L and Redman, S (2005) Medicine, Singapore 34(1): 8-15. Spatiotemporal patterns of dorsal root-evoked Whitworth, JA (2005) Competition in health network activity in the neonatal rat spinal cord: research: the experience of The John Curtin School Optical and intracellular recordings. Journal of of Medical Research. Australia and New Zealand Neurophysiology 94(3): 1952-1961. Health Policy 2(5). Zola, H, Swart, B, Nicholson, I, Aasted, B, Bensussan, Whitworth, JA (2005) Blood pressure and control A, Boumsell, L, Buckley, C, Clark, G, Drbal, K, of cardiovascular risk. Vascular Health and Risk Engel, P, Hart, D, Horejsi, V, Isacke, C, Macardle, Management 1: 257-260. P, Malavasi, F, Mason, D, Olive, D, Saalmueller, A, Schlossman, SF, Schwartz-Albiez, R, Simmons, P, Whitworth, JA, Williamson, P, Mangos, G, and Kelly, Tedder, TF, Uguccioni, M, and Warren, H (2005) JJ (2005) Cardiovascular consequences of cortisol CD molecules 2005: human cell differentiation excess. Vascular Health and Risk Management 1(4): molecules. Blood 106(9): 3123-3126. The John Curtin School of Medical Research 291-299. Annual Review 2005

68 Community Contact

Contact with our Community Community Contact We were enormously proud to congratulate Emeritus Professor Frank John Fenner, an Australian Living Legend, for his inclusion in the inaugural ACT Honour Walk, unveiled in April.

Contact with our Community

JCSMR participates in the “Walk for the Cure”. The John Curtin School had a team of 25 who participated in the Juvenile Diabetes Research Foundation’s annual Walk For the Cure in October.

Histologist The John Curtin School of Medical Research held the annual Mrs Anne Open Day during August. Open Day gives members of the Prins with public and school groups the opportunity to talk to scientists a group of in their working laboratories. Researchers in fi elds as diverse students as HIV, cancer, high blood pressure and hearing were touring available to demonstrate their work and answer questions. JCSMR with the National Youth Science Forum in Juvenile Diabetes fundraisers honoured. January. The Juvenile Diabetes Research Foundation presented JCSMR staff members Heather Domaschenz and Debbie Howard with a trophy for their efforts in raising over $5,000 for JDRF.

Mr Ken Roberts and Professor Chris Goodnow with Senator Gary Humphries after he opened National Youth Science Forum students from The Australian all over Australia visit Canberra in January, Phenomics Facility and visit laboratories within the School. in March. 70 71 Commitment to Serving our Community Voluntary Service 2005

Mr David Brettell, Chief Executive of the Australian Cancer Community Contact Research Foundation presented a cheque for $1.13 Staff and students of The John Curtin School of Medical Research continue to sit on numerous editorial million to JCSMR Director Professor Judith Whitworth and boards, and to assist a large number of national and international granting bodies as expert assessors. Professor Frances Shannon, Head of Molecular Bioscience, Some other voluntary activities are listed below. at the Canberra Cancerians Cocktail Party in May.

Contact with our Community

Ada Professor GL Member: Australian Infl uenza Vaccine Committee Scientifi c Patron: Austin Research Institute, Melbourne, VIC Presenter and Participant: National Youth Science Forum at JCSMR Course Presenter: ACT Senior Colleges: “The Importance of Vaccination” Baker Dr RT President and Executive Director: Genome Conference Inc Executive Director and Honorary Treasurer: The Australian Society for Medical Research Executive Council Member and Honorary Secretary: The Australian Society for Biochemistry and Molecular Biology Expert Consultant: Human Gene Nomenclature Committee, London Organizing Committee Member: International Congress on Yeast Genetics and Molecular Biology, Melbourne, 2007. Work Experience Supervisor: St Edmunds College, Canberra Bekkers Dr JM Associate Director: The Australian Advanced Neuroscience Research Initiative (AANRI), Moreton Bay Research Station, North Stradbroke Island, QLD

New JCSMR Xchange Place unveiled Board Professor PG Member: Pharmaceutical subcommittee of Australian Drug Evaluation Committee An integral space in the new John Curtin School of Medical Advisor: Parkinson’s NSW Inc Research building was offi cially named by ACT Deputy Chief Minister, Mr Ted Quinlan, in December. Chaudhri Dr G Xchange Place is an interactive meeting space in the National Honorary Secretary of the Australasian Society for Immunology Inc multimillion-dollar fi rst-stage of the new JCSMR building, Cowan Dr A which is due for completion in March 2006. Instructor and presenter: The Australian Advanced Neuroscience Research Initiative (AANRI), Moreton Bay Research Station, North Stradbroke Island, QLD Dulhunty Professor AF Member: International Union of Physiological Sciences (IUPS) Commission VI: Molecular and Cellular Physiology Board of Directors: ACT Orthopaedic Foundation Our Public Affairs Manager engages with the wider community about research activities in The John Curtin School of Medical Research. Easteal Professor S Head: Research Committee, JDRLegal Pty Ltd Staff and students are actively involved in communicating their research through Advisory Board: Sydney University Biological Informatics and Technology Centre, Sydney, NSW Advisory Board: ARC Bioinformatics Centre of Excellence, University of Queensland, Brisbane, QLD speaking engagements with clubs, school and community groups. We also encourage Expert Task Force: AusIndustry National Bioinformatics Strategy visitors to The School. Research Australia Representative: Science meets Parliament Organising Committee Member: Discovery Science and Biotechnology Conference, Melbourne, VIC A speaker for your group or a visit to the laboratories of The John Curtin School of Medical Research can be arranged by contacting our Public Affairs Manager, Dr Freeman Dr C Madeleine Nicol. Member: Canberra Region Scientifi c Meeting Planning Committee Advisor: ACT cancer website: http://www.hotkey.net.au/~string/listing T: +61 2 6125 2577 F: +61 2 6125 2337 E: [email protected] ACT representative: Matrix Biology Society of Australia and New Zealand

72 73 Voluntary Service 2005 Voluntary Service 2005 Voluntary

Voluntary Service to Organisations Outside JCSMR Voluntary Service to Organisations Outside JCSMR

Goodnow Professor CC Ramshaw Professor IA Deputy Chair: NHMRC Project Grants Review Panel 2a Scientific Advisory Panel Member: Westmead Institute for Cancer Research Scientific Advisory Committee: Australian Genome Research Facility Member: Smallpox Expert Committee Member: Australian Academy of Science Special Elections Committee Member: Infection and Immunity Strategic Advisory Committee, The Wellcome Trust, UK Redman Professor SJ Treasurer: International Brain Research Organization Gready Professor JE Board Member: Neurosciences Australia Ltd Convenor: Australian Society for Biochemistry and Molecular Biology Bioinformatics Special Interest Research Advisory Board Member: Prince of Wales Medical Research Institute Group Director: The Australian Advanced Neuroscience Research Initiative (AANRI), Moreton Bay Research Specialist Editor: Computer Physics Communications (Biophysics) Station, North Stradbroke Island, QLD

Hendry Professor IA Shannon Professor MF Science Advisor: Board of the Wenkart Foundation Editor: FEBS Letters (The Journal of the Federation of European Biochemical Societies) Hill Professor CE ACT Council Representative: Australian Society for Biochemistry and Molecular Biology Management Committee Member: Centre for Vascular Research, University of NSW, Sydney, NSW Cardiovascular Health Advisory Committee Member: National Board of the Heart Foundation ACT Representative: ANZ Microcirculation Society Simeonovic Dr CJ Hulett Dr M Elected Council Member, Society Liaison Officer and Education Officer: The Transplantation Society of Australia and New Zealand (until May) ACT Convenor: Australian Society for Medical Research (until November) Director: Australian Society for Medical Research (from November) Stricker Associate Professor C Mentor: ANU Distinguished scholars program Instructor and presenter: The Australian Advanced Neuroscience Research Initiative (AANRI), Moreton Huttley Dr G Bay Research Station, North Stradbroke Island, QLD Member: Program committee for the 4th Asia-Pacific Bioinformatics Conference Stuart Dr GJ Karupiah Dr G ACT Presenter: Brain Awareness Week ACT Councillor: The Australasian Society for Immunology Inc Tierney Dr ML Councillor: The Federation of Immunological Societies of Asia-Oceania Organising Committee Member: Joint Australian Physiological Society & Australian Society for Lamb Professor TD Biophysics Advisory Editor: Journal of General Physiology Tremethick Dr DJ Matthaei Dr KI Invited analyst: Chemtract Consultant: Australian Quarantine Inspection Service Young Professor IG Member: Stem Cell Ethics Australia Advisory Committee Editor: DNA Sequence Member: NHMRC Training Awards Scholarships Committee Member: Biological Defence Advisory Committee, (Department of Defence) Affiliate member: Centre for the Molecular Genetics of Development Member: ARC Centre for Network in Genes and Environment in Development Whitworth Professor JA Patron: TADACT, Technical Aid to the Disabled ACT Parish Professor C Patron: Wesley Institute, QLD Editor-in-Chief: Immunology and Cell Biology Honorary Ambassador for Women Medical Research Advisory Committee Member: The Australian Cancer Research Foundation Ambassador for Canberra ANU representative: Program Management Committee of the Australian HIV Vaccine Consortium Trustee: High Blood Pressure Research Council of Australia Past President of the Australasian Society for Immunology Inc Director: Research Australia Council Member: The International Union of Immunological Societies (IUIS) Council Member: Charles Darwin University Council member: Australasian Society of Clinical Immunology and Allergy Board Member: Menzies School of Health Research Board Member: Menzies Research Institute

74 75 Voluntary Service 2005 Voluntary

Voluntary Service to Organisations Outside JCSMR Support to the School

Chair: Research and Development Advisory Committee, The George Institute, Sydney, NSW Member: National Health and Medical Research Council Chair: Global Advisory Committee on Health Research, WHO • Grants Member: WHO Expert Advisory Panel on Health Science and Technology Policy • Statistics Member: WHO/ISH Liaison Committee Member: ISH International Scientific Program Committee • Donors Writing Committee Co-Chair: WHO/ISH Guidelines Chair: Selection Panel for the Commonwealth Health Minister’s Award for Excellence in Health and Medical Research Director: Australian Science Festival Ltd (ASF) Chair: National Neuroscience Taskforce Member: Centenary of Canberra Taskforce

The John Curtin School of Medical Research Annual Review 2005

76 Grants 2005 Grants 2005 Grants 2005 Grants

Grants

Australian Cancer Research Foundation Professor AF Dulhunty Australian Research Council Linkage Grants National Health and Medical Research Council Professor C Parish, Professor F Shannon, Regulation of ryanodine receptor calcium channels by Dr MG Casarotto Peter Doherty Fellowship Professor P Board, Professor C Goodnow, Dr D the calcium binding protein calsequestrin. Molecular Interactions of chemical agents with ion Dr L Simson Tremethick, Dr D Taupin, Dr H Warren, Professor I $100,000 channel proteins $66,000 Ramshaw, Professor R Saint and Dr A Blackburn Professor AF Dulhunty, Dr DR Laver and Dr MG $70,000 National Health and Medical Research Council An integrated biomolecular resource facility for Casarotto Dr CJ Easton and Dr MG Casarotto Program Grants cancer biology research Intrinsic properties of the pore forming domain of the Synthetic compounds to specifically activate or Professor AF Jorm, Professor H Christensen, Dr B $1,130,000 ryanodine receptor calcium channel inhibit ryanodine receptor calcium ion channels Rodgers, Professor S Easteal, Dr K Anstey $150,000 Australian Center for HIV and Hepatitis $68,000 Epidemiology of high prevalence mental disorders: Research Professor S Easteal, Dr R Trent, Dr K North, Dr B Yu, Professor TJ Andrews, Professor JE Gready and Aetiology, course and public health intervention Dr J Gulbin, Dr AG Hahn and Dr N Yang Dr SA Thomson, Professor IA Ramshaw, Dr P White, Professor G Otting $50,000 Identifying genes that modify athletic performance Professor R Ffrench, Dr W Rawlinson, Dr A Lloyd Why is the photosynthetic CO2-fixing enzyme, Professor PS Foster, Dr SP Hogan, Dr KI Matthaei, Dr $75,000 HCV Vaccine Design and Development Team Rubisco, so inefficient? Dissection of the catalytic PI Thompson and Professor IG Young Professor S Easteal, Dr GA Huttley, Dr AV Isaev and (HCVVDDT) chemistry by computational simulation and Molecular Mechanisms in the Regulation of Allergy Dr MJ Wakefield $40,000 experimental testing and Inflammation Adaptive evolution of BRCA1 in ancestral mammals $215,000 $970,000 Australian Research Council Centre of $75,000 Dr GA Huttley, Dr A Isaev and Cray Australia P/L Excellence Professor C Chesterman, Dr R Andrews, Dr M Berndt, Professor PW Gage Novel bioinformatics approaches for biological Professor B Chong, Professor P Hogg, Dr M Hulett, Professor P Gresshoff, Professor C Beveridge, Dr B Ion channels formed by small proteins from viruses inference from comparative genomics data Associate Professor L Khachigian and Professor C Carroll, Professor B Rolfe, Professor C Parish, Dr M $90,000 $30,000 Parish Djordjevic, Dr G Weiller, Dr U Mathesius, Dr R Rose, Professor JE Gready, Dr PL Cummins, Dr AA Bliznyuk, Howard Hughes Medical Institute, USA Vascular Biology Professor M Singh and Dr P Bhalla Professor U Rothlisberger, Professor S Ragsdale Dr G Karupiah $2,000,000 Integrative Legume Research Towards a complete description of how enzymes Immune response to viral infection Professor P Doherty, Professor IA Ramshaw, Professor $2,000,000 work: development of simulation methods and $93,000 D Cooper and Associate Professor S Kent Australian Research Council Centre of protocols, blind test predictions, and experimental Studies of HIV-1 infection and vaccination Human Frontiers Science Program Grant Excellence in Vision Science validation $350,000 S Kawamura, EN Pugh, Professor TD Lamb and Y Professor TD Lamb Co-Director $85,000 Professor MF Shannon Fukada $1,100,000 Professor CE Hill The role of c-Rel in T cells gene transcription: a model Phototransduction mechanisms in cones Australian Research Council Federation Involvement of cell coupling in vascular function: of chromatin remodeling $US89,000 Fellowship Development of a computational model $152,000 Professor TD Lamb Total $91,600 Juvenile Diabetes Research Foundation Professor TD Lamb National Health and Medical Research Council The first stage of vision: Transduction and adaptation Professor C Goodnow Project Grants Suction pipette measurements of mammalian rod Molecular analysis of pathways in diabetes retinal photoreceptors Dr E Bertram photoreceptor recovery following intense bleaching $660,000 $300,000 Costimulatory mechanisms for enhancing CD8 T cell exposures National Health and Medical Research Council responses during an acute respiratory infection Australian Research Council Discovery Grants $60,000 Dr RT Baker Capacity Building Grant $144,250 Role of a novel zinc-binding motif in the structure- Australian Research Council LIEF Grant Professor T Dwyer, Dr G Jones, Dr A Venn, Dr L Professor PG Board function of deubiquitinating enzymes Dr NE Dixon, Professor G Otting, Professor CJ Easton, Blizzard, Professor S Easteal, Dr A-L Ponsonby and Pharmacogenetic investigations of glutathione $75,000 Professor JE Gready, Professor TJ Andrews, Dr JL Professor P Zimmett transferases Professor PG Board Beck, Dr MR Wilson, Professor SG Pyne, Dr MJ Walker, $500,000 $154,500 Professor Lal Kane-Maguire, Dr PA Keller, Dr SF A genomic and phenomic investigation of a National Health and Medical Research Council Professor PG Board, Professor AF Dulhunty and Lincoln, Professor JA Carver mitochondrial glutathione transferase Equipment Grant Professor PW Gage Facility for the Analysis of Biomacromolecular $80,000 Dr DJ Tremethick CLICs and GSTs : New ion channel modulators Interactions Professor PG Board and Dr M Casarotto Automating the JCSMR Microscopy Unit $131,500 $432,000 Cellular uptake of glutathione transferases and their epifluorescence microscope development as cell transfection agents $128,190 $110,000

78 79 Grants 2005 Gramts 2005 Gramts Grants Grants

Dr G Chaudhri and Dr G Karupiah Professor CE Hill and Dr T Grayson Dr A Gulledge and Dr GJ Stuart Pharmaxis Ltd Critical role of TNF in host-virus interactions and Myoendothelial Gap Junctions: their composition and Mechanisms and consequences of cholinergic Dr WB Cowden and Dr B Charlton outcome of infection: Involvement of reverse role in vasodilator responses attributed to EDHF signaling in neocortical pyramidal neurons Investigation of phosphosugars as anti-inflammatory signalling through mTNF $85,000 $84,750 drugs $165,000 Professor GDS Hirst and Dr FR Edwards Dr DJ Tremethick and Dr P Ridgway $675,000 Professor AF Dulhunty Intramuscular interstitial cells of Cajal; Channels The role of heterochromatin in regulating cellular Viertel Senior Medical Research Fellowship Characteristics of splice variants of the skeletal and their modulation by calcium ions and proliferation and development Dr MD Hulett muscle ryanodine receptor: implications for myotonic neurotransmitters $165,000 per year Regulators of cell invasion and angiogenesis dystrophy $161,000 Dr HS Warren $165,000 $85,000 Dr G Karupiah Receptors and Ligands Regulating Human NK Cell Professor AF Dulhunty, Professor PG Board and Dr Role of plasmacytoid dendritic cells and neutrophils Proliferation Wellcome Trust MG Casarotto in the generation of antiviral immunity $136,242 Professor C Goodnow A programme of ENU mutagenesis to identify the Protein/protein interactions between two calcium $154,000 National Health and Medical Research Council pathways governing lymphocyte responses to antigen channels Professor NJC King, Dr G Karupiah, Dr A Kesson and Senior Research Fellowships $106,822 $130,000 Dr G Chaudhri Dr G Karupiah Professor AF Dulhunty, Professor GD Lamb, and Dr Critical soluble effector molecules causing immune $114,500 MG Casarotto damage in a model of West Nile virus encephalitis Dr HS Warren Specific modification of RyR activity $87,500 $109,750 $130,000 Professor TD Lamb Professor PW Gage Electroretinogram recordings of human scotopic dark National Health and Medical Research Council Senior Principal Research Fellowships Effects of mutations in the conserved cysteine loop of adaptation following intense bleaching exposures Professor PW Gage the GABA receptor. $119,250 A $130,000 $137,000 Professor TD Lamb, BA Patterson and FN Reinholz Professor GDS Hirst Professor PW Gage, E Gowans, G Haqshenas Properties of human cone photoreceptors measured $141,500 Hepatitis virus assembly using a scanning laser ophthalmoscope to illuminate $158,250 and image the retina National Heart Foundation Grant-in-Aid Professor C Goodnow $118,575 Professor CE Hill and Dr T Grayson Genetic and biochemical mechanisms dysregulating Dr M Lobigs and Dr E Lee Variation in the expression of subtypes of intracellular CD4 T cell tolerance Coordinated cleavages in the flavivirus structural IP3 and ryanodine calcium stores within and between $145,000 polyprotein: role in virus assembly and host/pathogen arteries. Professor C Goodnow and Dr C Vinuesa interaction $49,833 Mechanisms controlling antibody production and B $90,000 National Institutes of Health, USA cell signaling Dr SC Barry, Professor MF Shannon, Dr H Zola H and Professor C Goodnow $150,000 Dr R D’Andrea Genes for Tolerance and Immunity Consortium Professor C Goodnow and Dr C Vinuesa Molecular Identification of FoxP3 positive regulatory $718,553 Defining the immunoregulatory function of Roqin: a T cells Professor IA Ramshaw and Dr SA Thomson novel gene essential for preventing autoimmunity $472,000 HIV Vaccine Design and Development Program $270,250 Dr CJ Simeonovic and Professor A Gibbs $376,000 Professor C Goodnow, Dr C Vinuesa, Dr M Cook and Major xenoantigens for neovascularised porcine Professor REW Fyffe and Professor B Walmsley Dr G Huttley xenografts: the role of PERV and MHC in rejection Integrative Mechanisms in the Central Nervous Translational study of the genetics of systemic and tolerance System autoimmunity based on mouse mutagenesis $160,000 $US500,000 $110,600 Dr GJ Stuart Professor IA Hendry Dendritic mechanisms underlying synaptic plasticity New South Wales Cancer Council The proteins associated with the neurotrophin $127,000 Professor C Parish, Dr J Altin, Dr P Hogg and retrograde transport signalling endosome Professor C Chesterman $95,000 Tumour angiogenesis $196,000

80 81 Statistics 2005 Donors 2005 Donors 2005

Thank you to the donors who continue to support research programs in The John Curtin School of Medical Research. Statistics 2005 We are extremely grateful for their support during 2005.

Staff Numbers 2005 2004 2003 In 2005 we would particularly like to thank: Academic staff 96 96 85 T Acev M Evaggelidis General Staff — administration, technical & support 219 212 172 ACT School Counsellors F Fenner Postgraduate students 84 76 77 G Ada Family and Friends of K Field

W and E Anderson V Field

S Antonakos J Fildes

I Arginov F Forace

Family and Friends of E Austrums Family and Friends of J Forace Income EM Azzopardi R Forace Base Allocation $14,062,000 GB Blazevski CJ Forbes IGS, RTS, RIBG $4,350,000 Adjustments $300,000 B Bosko G Frilingos Other Income $1,530,000 K and Z Boskov J and C Frilingos Special Purpose Funds (SPF) $18,192,000 G Box M Galeff TOTAL INCOME $38,434,000 B and J Boyes J Gani S Bozinovski L Gelmanovski and family

F Brazil S and L Gelmanovski and family

Expenditure I Brdar Family and Friends of Fay Gibbons Staff Costs $13,297,000 B Buseska I Gibbons Scholarships $1,120,000 N and D Buseski V Gibbons Equipment $928,000 Mr and Mrs Cadwallader A Gibbons Travel $581,000 J Calokerinos C Gibbons Expendable Research Material (ERM) $2,074,000 TE Caruana R Gill Other $1,976,000 H Cassidy DW Greenow Special Purpose Funds (SPF) $18,192,000 A Castrisios S Haridemos S TOTAL EXPENDITURE $38,168,000 CAUDIT (Council of Australian University C and M Himonas Directors of Information Technology) A Hodgett PT Comino Special Purpose Funds G T Hutchinson G Condoleon Overseas Grants $1,400,000 BZ Ivanovska L and L Damcevski Government Grants $13,547,000 J Joudauosiv G Dariol Other $3,245,000 V Kalokerinos TOTAL $18,192,000 D Dimov M Kapinov A Doikos T Kartolefv J and V Dzelde V Kasimatis T Efkarpidis

82 83 Donors 2005 Donors Donors

S Kendrick Mr and Mrs Rose

F Kostovska J Roufogalis

D Kresoya T Samios

S Lynskey S Schnakenberg

Macedonian Women’s Group B Skein

B Markoska M Smith

M McBride C Spanos

H McLoughlin V Spiliopovlos

ID and HG McNee E Spinner

E and E Metelovski and family M Spirovski The John Curtin School of P Miller M and S Spiteri Medical Research Needs N Moulis A Stellios A Your Support S Moutafi s B and P Stone Gifts and bequests to the School are V Nicevski J, C and E Strickland used to fund vital research projects in J Nicolson H Talevich areas such as asthma, cancer, diabetes, J and V Nikolovski M Tamvakis high blood pressure, hearing loss and vision, as well as providing scholarships R Nocevski S Tanevski and Family and purchasing specialised equipment. EH Notaras The Combined Probus Club of Your support can be provided in a Cooleman Inc D Olidis number of ways. These could include K O’Sullivan S Themelkos a gift or bequest that may assist in funding a particular area of research, or a C Pangaski R and S Trajkovska scholarship or prize. C Panteli M and T Trajkovski If you would like to discuss options for E Pappos A Tsagris supporting The John Curtin School of E Vasiliou R Paterson Medical Research, please contact: T and M Petkovski N Vasiliou Dr Madeleine Nicol R Petrohilos S Vizovitis T: +61 2 6125 2577 F: +61 2 6125 2337 A Pickering M and D Williams M: 0407 278 913 E: [email protected] R and E Price P Wilmot

J Prineas G Woodroofe

S Rice J and V Zafi ris

84 Published in Australia by The John Curtin School of Medical Research The Australian National University Editors: Dr Madeleine Nicol and Frith Rayner Design & Layout: Sue Henderson and Karen Edwards Photography: Julie Macklin Additional Photographs: Karen Edwards & Marc Fenning The John Curtin School of Medical Research The Australian National University

Building 54, Mills Road Garran Road Canberra ACT 0200 Australia T: +61 2 6125 2550 F: +61 2 6125 2337 E: [email protected]

W: jcsmr.anu.edu.au http://annualreport.jcs.anu.edu.au/2005/