ABCB5 Recombinant Cat. No.: 92-176

ABCB5 Recombinant Protein

Specifications

SPECIES: Human

SOURCE SPECIES: E. coli

SEQUENCE: Ile141-Val247

FUSION TAG: N-Trx tag

TESTED APPLICATIONS:

APPLICATIONS: This recombinant protein can be used for biological assays. For research use only.

PREDICTED MOLECULAR 29.4 kD WEIGHT:

Properties

Greater than 95% as determined by reducing SDS-PAGE. PURITY: Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

PHYSICAL STATE: Lyophilized

Lyophilized from a 0.2 um filtered solution of 20mM PB，150mM NaCl,pH7.4. It is not BUFFER: recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

September 23, 2021 1 https://www.prosci-inc.com/abcb5-recombinant-protein-92-176.html Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks. STORAGE CONDITIONS: Reconstituted protein solution can be stored at 4-7˚C for 2-7 days. Aliquots of reconstituted samples are stable at -20˚C for 3 months.

Additional Info

OFFICIAL SYMBOL: ABCB5

ALTERNATE NAMES: ATP-binding cassette sub-family B member 5, P-glycoprotein ABCB5, ABCB5 P-gp, ABCB5

ACCESSION NO.: Q2M3G0

GENE ID: 340273

Background and References

ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant . ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in BACKGROUND: human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.

ANTIBODIES FOR RESEARCH USE ONLY.

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September 23, 2021 2 https://www.prosci-inc.com/abcb5-recombinant-protein-92-176.html