DOCSLIB.ORG

2008 Conference Syllabus

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
2008 Conference Syllabus 3rd ADVAN 3rd ABSTRACT BOOK C E S AGAIN ST A S PE R GILL OS I S • January 16-19, 2008 3rd ADVANCES AGAINST ASPERGILLOSIS January 16-19, 2008 Miami Beach Resort & Spa Miami, Florida, USA University of California, San Diego School of Medicine 3RD ADVANCES AGAINST ASPERGILLOSIS January 16-19, 2008 Miami Beach, Florida ACKNOWLEDGEMENTS We would like to offer very special thanks to the following organizations for their generous educational grants. Their financial support makes this conference possible Platinum Gold Silver 3RD ADVANCES AGAINST ASPERGILLOSIS January 16-19, 2008 Miami Beach, Florida We would also like to thank the following companies for contributing their financial support and educational exhibits to this conference. We encourage you to take this opportunity to meet and share your ideas and experiences with the exhibit representatives. 3RD ADVANCES AGAINST ASPERGILLOSIS January 16-19, 2008 Miami Beach, Florida TABLE OF CONTENTS Conference Chairmen, Scientific Committee. 1 Faculty List. 3 Faculty Disclosures. 7 Scholarship Awards. 11 Poster Abstract Index. 13 Final Program Wednesday, January 16. 21 Thursday, January 17. 23 Friday, January 18. 25 Saturday, January 19 . 27 Abstracts Invited Faculty. 29 Oral Abstract Presenters. 85 Poster Abstracts. 91 Author Index. 189 3RD ADVANCES AGAINST ASPERGILLOSIS January 16-19, 2008 Miami Beach, Florida CONFERENCE CHAIRMAN AND SCIENTIFIC COMMITTEE Chairmen David W. Denning, MD / University of Manchester, UK William J. Steinbach, MD / Duke University, USA David A. Stevens, MD / Stanford University, USA Scientific Committee Scott E. Baker, PhD / Pacific Northwest National Laboratory, USA Arunaloke Chakrabarti, MD / Postgraduate Institute of Medical Education & Research, India Karl V. Clemons, PhD / Stanford University, USA Reinhard Fischer, PhD / University of Karlsruhe, Germany Donna Haiduven, PhD / University of South Florida, USA Katsuhiko Kamei, MD, PhD / Chiba University, Japan Dimitrios P. Kontoyiannis, MD / University of Texas MD Anderson Cancer Center, USA Jean-Paul Latgé, PhD / Institut Pasteur, France Johan Maertens, MD / University Hospital Gasthuisberg, Belgium Richard B. Moss, MD / Stanford University, USA David S. Perlin, PhD / UMDNJ - New Jersey Medical School George A. Sarosi, MD / Indiana University, USA John R. Wingard, MD / University of Florida, USA Sally E. Wenzel, MD / University of Pittsburgh, USA 3RD ADVANCES AGAINST ASPERGILLOSIS January 16-19, 2008 Miami Beach, Florida FACULTY Jill Adler-Moore, MD Michael J. Day, PhD California State Polytechnic University, USA University of Bristol, UK Ryoichi Amitani, MD David W. Denning, MD Kyoto University, Japan University of Manchester, UK Elias J. Anaissie, MD Richard D. deShazo, MD University of Arkansas, USA University of Mississippi, USA Arunmozhi Balajee, PhD Dennis M. Dixon, PhD Centers for Disease Control and Prevention, USA National Institute of Allergy and Infectious Diseases, USA Scott E. Baker, PhD Pacific Northwest National Laboratory, USA Richard H. Drew, PharmD Duke University, USA Joan W. Bennett, PhD Rutgers University, USA Natalie D. Fedorova, PhD The Institute for Genomic Research, USA John E. Bennett, MD National Institute of Allergy and Infectious Diseases, Scott G. Filler, MD USA Harbor-UCLA Medical Center, USA Rosemary Boyton, PhD Reinhard Fischer, PhD Imperial College, UK University of Karlsruhe, Germany Arunaloke Chakrabarti, MD Jens Frisvad, PhD Postgraduate Institute of Medical Education & Technical University of Denmark, Denmark Research, India David M. Geiser, PhD Pranatharthi H. Chandrasekar, MD Pennsylvania State University, USA Wayne State University, USA Donna Haiduven, PhD Thomas M. Chiller, MD University of South Florida, USA Centers for Disease Control and Prevention, USA Dominik Hartl, MD PhD Karl V. Clemons, PhD Ludwig-Maximilians-University, Germany Stanford University, USA Tobias Hohl, MD PhD Robert A. Cramer, Jr., PhD Memorial Sloan Kettering Cancer Center, USA Montana State University, USA 3RD ADVANCES AGAINST ASPERGILLOSIS January 16-19, 2008 Miami Beach, Florida Steven M. Holland, MD Jean-Paul Latgé, PhD National Institute of Allergy and Infectious Diseases, Institut Pasteur, France USA Thomas Lehrnbecher, MD PhD William W. Hope, MD Johann Wolfgang University of Frankfurt, Germany University of Manchester, UK James S. Lewis, PharmD Hiroyuki Horiuchi, PhD University of Texas - San Antonio, USA University of Tokyo, Japan Johan Maertens, MD Shahid Husain, MD University Hospital Gasthuisberg, Belgium University of Pittsburgh, USA Francisco M. Marty, MD James I. Ito, MD Harvard Medical School, USA City of Hope National Medical Center, USA Laurence F. Mirels, MD Katsuhiko Kamei, MD, PhD Stanford University, USA Chiba University, Japan Jose G. Montoya, MD Corne Klaassen, PhD Stanford University, USA Canisius Wilhelmina Hospital, The Netherlands Richard B. Moss, MD Michael Kleinberg, MD PhD Stanford University, USA University of Maryland, USA William C. Nierman, PhD Lena Klingspor, MD PhD The Institute for Genomic Research, USA Karolinska Institute, Sweden Nir Osherov, PhD Olaf Kniemeyer, PhD Tel-Aviv University, Israel Leibniz Institute for Natural Product Research and Infection Biology, Germany Alessandro C. Pasqualotto, MD PhD University of Manchester, UK Jay K. Kolls, MD University of Pittsburgh, USA Thomas F. Patterson, MD University of Texas - San Antonio, USA Dimitrios P. Kontoyiannis, MD University of Texas MD Anderson Cancer Center, David S. Perlin, PhD USA UMDNJ-New Jersey Medical School, USA June Kwon-Chung, PhD Gordon Ramage, PhD National Institute of Allergy and Infectious Diseases, Glasgow Caledonian University, UK USA Nick Read, PhD University of Edinburgh, UK 3RD ADVANCES AGAINST ASPERGILLOSIS January 16-19, 2008 Miami Beach, Florida Luigina Romani, MD PhD Abba I. Terr, PhD University of Perugia, Italy Terr Medical Corporation, USA Robert A. Samson, PhD Paul E. Verweij, MD PhD Centraalbureau voor Schimmelcultures University Medical Centre Nijmegen, The The Netherlands Netherlands George A. Sarosi, MD Suresh P. Vyas, PhD Indiana University, USA Dr. Harisingh Gour University, India Mark S. Schubert, MD PhD University of Arizona Thomas J. Walsh, MD Allergy Asthma Clinic, USA National Cancer Institute, USA Stefan Schwartz, MD David J. Weber, MD MPH Charité - Universitätsmedizin Berlin, Germany University of North Carolina, USA Brahm H. Segal, MD Nathan P. Weiderhold, PharmD Roswell Park Cancer Institute, USA University of Texas - San Antonio, USA Kent Sepkowitz, MD Sally E. Wenzel, MD Memorial Sloan-Kettering Cancer Center, USA University of Pittsburgh, USA Nina Singh, MD John R. Wingard, MD University of Pittsburgh, USA University of Florida, USA William J. Steinbach, MD De Yang, PhD Duke University, USA National Cancer Institute, USA David A. Stevens, MD Teresa Zelante, PhD Stanford University, USA University of Perugia, Italy 3RD ADVANCES AGAINST ASPERGILLOSIS January 16-19, 2008 Miami Beach, Florida Course Description~ The Aspergillus field is in a state of rapid advancement, including wonderful genomic and molecular advances providing a huge impetus for basic and translational research. Additionally, the launch of several newer antifungals in the last few years and anticipated clinical trials of several more is a tremendous important therapeutic step forward. Despite the incidence of invasive aspergillosis increasing and the disease as the leading fungal cause of patient mortality, prior to the 1st Advances Against Aspergillosis meeting there had been insufficient communication among experts in the area. Here in 2008 is another rare chance to gather the world's aspergillosis experts in one venue. A continuing fundamental tenet of this research colloquium continues to be to engender collaborative relationships amongst clinicians, scientists, and industry to further advance the field. The sessions are purposefully designed to intermingle the clinical and scientific aspects on a specific topic Objectives~ Recognize the therapeutic gaps in treating patients with invasive aspergillosis. Debate the various methodologies surrounding further molecular advances. Create new relationships between scientists and clinicians. Statement of Need~ The content of this educational program was determined by rigorous assessment of educational need including surveys, program feedback, expert faculty assessment, literature review, research findings, medical practice and new medical knowledge. Target Audience~ The program is intended for Infectious Disease Specialists, Mycologists, Hematologist/Oncologists, Transplantation Specialists, Chest Physicians, Allergists, Clinical Microbiologists, Molecular Biologists, Immunologists, Basic Scientists, Geneticists, Pharmacists, Epidemiologists, Public Health Specialists, Environmental/Facility, Specialists, and Veterinarians Accreditation~ AMA: The University of California, San Diego School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The University of California, San Diego School of Medicine designates this educational activity for a maximum of 22.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity. BBS: This course meets the qualifications for 22.5 hours of continuing education credit for MFTs and/or LCSWs as required by the California Board of Behavioral Sciences. (UCSD Provider Number PCE 683) 3RD ADVANCES AGAINST ASPERGILLOSIS January 16-19, 2008 Miami Beach,
Load more

Recommended publications
  • A Study of T Cell Receptor Usage in Allergic Asthma and Analysis of a Humanised T Cell Receptor Transgenic Model of Immunity to Allergen
    A Study of T Cell Receptor Usage in Allergic Asthma and Analysis of a Humanised T Cell Receptor Transgenic Model of Immunity to Allergen A thesis submitted for the degree of Doctor of Philosophy by Tracey Elizabeth Pollard at Imperial College, London Lung Immunology Group, National Heart and Lung Institute, Faculty of Medicine, Sir Alexander Fleming Building, South Kensington campus, Imperial College, London SW7 2AZ Supervisors: Dr Rosemary J. Boyton Prof. Daniel M. Altmann June 2009 Abstract It has been previously shown that the length of complementarity-determining region 3 (CDR3) loops of a T-cell receptor (TCR) may determine T-cell phenotype, with elongated CDR3s being favoured in T helper-type 2 (Th2) cells. Here, in a human system of Th2-mediated allergic asthma, TCR CDR3 usage has been studied in T-cell lines derived from Human Leukocyte Antigen (HLA)-DR1-positive, cat-allergic asthmatic subjects, and generated against peptide 4, a T-cell epitope of the major cat allergen Fel d 1. Populations of T-cells expanded that expressed particular TCRs carrying elongated CDR3a or p loops. A system was developed to transduce the immortalised TCR-negative murine thymoma line BW7 with the human TCR genes identified here and also murine Thl and Th2 associated TCR genes identified from previous work in our laboratory to allow further study of the influence of TCR structure on T-cell phenotype. A TCR/MHC class II transgenic model of allergic asthma has been developed by others in our laboratory. As part of the initial characterisation of this model, to establish if the TCR was expressed, the impact of the presence of the TCR transgenes on thymic selection and the expression of costimulatory molecules was studied.
    [Show full text]
  • Natural Killer Cell Subsets and Multiple Sclerosis
    Natural Killer Cell Subsets and Multiple Sclerosis Alison Jane Harris Imperial College London Department of Medicine Thesis submitted for the degree of Doctor of Philosophy 1 Declaration of Originality I hereby declare that the work presented here is my own and that all references to the work of others are accompanied by appropriate citations. 2 ABSTRACT This thesis addresses the hypothesis that multiple sclerosis (MS) patients have an imbalance in the frequencies of natural killer cell subsets, with fewer immunoregulatory and more proinflammatory NK cells compared to healthy controls. Ten NK cell subsets were defined according to expression of CD56, CD8, CD27 and CD57. Subset frequencies were compared by performing multiparameter flow cytometry on PBMCs from healthy controls and patients with clinically isolated syndrome (CIS) or relapsing-remitting MS. CD56dim CD8+ CD57+ CD27- NK cells had a higher frequency in untreated relapsing-remitting MS patients compared to healthy controls and their frequency was decreased in patients on interferon-β treatment. CD56bright NK cells, particularly the CD8- CD27- subset, had a significantly lower frequency in untreated MS and CIS patients. CD8- CD57- CD27- subsets of both CD56dim and CD56bright NK cells were expanded in interferon-β-treated patients in remission but not relapse. Characteristics of two CD56dim subsets displaying an apparent reciprocal relationship (CD8+ CD57+ CD27- and CD8- CD57- CD27-) were compared by qRT-PCR, flow cytometry and killing assays. CD56dim CD8+ CD57+ CD27- NK cells were more cytotoxic and expressed higher levels of transcripts encoding IFNγ, T-bet and other factors associated with IFNγ signalling. This is consistent with the hypothesis that there is a shift towards a more pro-inflammatory NK cell phenotype in MS patients, which is reversed by interferon-β treatment.
    [Show full text]
  • Infliximab Is Associated with Attenuated Immunogenicity to Bnt162b2 and Chadox1 Ncov-19 SARS-Cov-2 Vaccines in Patients With
    Inflammatory bowel disease Original research Infliximab is associated with attenuated Gut: first published as 10.1136/gutjnl-2021-324789 on 26 April 2021. Downloaded from immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS- CoV-2 vaccines in patients with IBD Nicholas A Kennedy ,1,2 Simeng Lin ,1,2 James R Goodhand ,1,2 Neil Chanchlani ,1,2 Benjamin Hamilton ,1,2 Claire Bewshea ,2 Rachel Nice,2,3 Desmond Chee ,1,2 JR Fraser Cummings ,4 Aileen Fraser ,5 Peter M Irving ,6,7 Nikolaos Kamperidis,8 Klaartje B Kok ,9,10 Christopher Andrew Lamb ,11,12 Jonathan Macdonald ,13,14 Shameer Mehta ,15 Richard CG Pollok ,16,17 Tim Raine ,18 Philip J Smith ,19 Ajay Mark Verma ,20 Simon Jochum,21 Timothy J McDonald ,3 Shaji Sebastian ,22,23 Charlie W Lees ,24,25 Nick Powell ,26,27 Tariq Ahmad ,1,2 Contributors to the CLARITY IBD study ► Additional supplemental ABSTRACT material is published online Objective Delayed second dose SARS- CoV-2 vaccination Significance of this study only. To view, please visit the trades maximal effectiveness for a lower level of immunity journal online (http:// dx. doi. org/ What is already known on this subject? 10. 1136/ gutjnl- 2021- 324789). across more of the population. We investigated whether patients with inflammatory bowel disease treated with ► A growing number of countries, including the For numbered affiliations see UK, have opted to delay second SARS- CoV-2 end of article. infliximab have attenuated serological responses to a single dose of a SARS- CoV-2 vaccine. vaccine doses for all people, trading maximal effectiveness against a lower level of protective Correspondence to Design Antibody responses and seroconversion rates Dr Tariq Ahmad, in infliximab- treated patients (n=865) were compared immunity across more of the at- risk population.
    [Show full text]
  • Prior SARS-Cov-2 Infection Rescues B and T Cell Responses to Variants After First Vaccine Dose
    REPORTS Cite as: C. J. Reynolds et al., Science 10.1126/science.abh1282 (2021). Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose Catherine J. Reynolds1†, Corinna Pade2†, Joseph M. Gibbons2†, David K. Butler1, Ashley D. Otter3, Katia Menacho4, Marianna Fontana5,6, Angelique Smit5, Jane E. Sackville-West7, Teresa Cutino-Moguel4, Mala K. Maini8, Benjamin Chain8, Mahdad Noursadeghi8, UK COVIDsortium Immune Correlates Network‡, Tim Brooks3, Amanda Semper3, Charlotte Manisty4,9, Thomas A. Treibel4,9, James C. Moon4,9, UK COVIDsortium Investigators‡, Ana M. Valdes10,11, Áine McKnight2§, Daniel M. Altmann12§, Rosemary Boyton1,13§* 1Department of Infectious Disease, Imperial College London, London, UK. 2Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. 3National Infection Service, Public Health England, Porton Down, UK. 4St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK. 5Royal Free London NHS Foundation Trust, London, UK. 6Division of Medicine, University College London, London, UK. 7James Wigg Practice, Kentish Town, London, UK. 8Division of Infection and Immunity, University College London, London, UK. 9Institute of Cardiovascular Science, University College London, London, UK. 10Academic Rheumatology, Clinical Sciences, Nottingham City Hospital, Nottingham, UK. 11NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Downloaded from Nottingham, Nottingham, UK. 12Department of Immunology and Inflammation, Imperial College London, London, UK. 13Lung Division, Royal Brompton and Harefield Hospitals, London, UK. *Corresponding author: Email: [email protected] †These authors contributed equally to this work. §These authors contributed equally to this work. http://science.sciencemag.org/ ‡UK COVIDsortium Investigators and UK COVIDsortium Immune Correlates Network collaborators and affiliations are listed in the supplementary materials.
    [Show full text]
  • ZIKA RAPID RESPONSE PROJECTS MRC NEWTON WELLCOME TRUST with Support from FAPESP MARCH 2016 ZIKA Reference PI Name PI Research Or
    ZIKA RAPID RESPONSE PROJECTS MRC NEWTON WELLCOME TRUST with support from FAPESP MARCH 2016 FINAL ZIKA PI Research PI Name Project Title Mth MRC Reference Organisation AWARD ZK/16-010 Zika: The Ecology of Zika Heather University of transmission in Colombia and 18 £108,815 Ferguson Glasgow Ecuador ZK/16-011 Zika: Defining the antigenic Yorgo University of epitopes in the Zika virus 18 £155,917 Modis Cambridge envelope protein Zika: Characterisation of Zika ZK/16-012 virus neutralisation and virion David CVR, University of structure by cryogenic electron 18 £133,141 Bhella Glasgow microscopy and 3D reconstruction Zika: Transmission dynamics ZK/16-017 London School of and impact of zika virus on Jimmy Hygiene and population health in a large 18 £148,000 Whitworth Tropical Medicine urban centre in northeastern Brazil Zika: Harnessing plant power ZK/16-018 University of for rational design of Janet Daly 18 £93,638 Nottingham immunogens for use in diagnostic assays Zika: Affordable, scalable, low- ZK/16-019 Liverpool School technology transfluthrin Gerry of Tropical emanators for protecting against 18 £148,971 Killeen Medicine transmission in low-income countries ZK/16-021 Steven Lancaster Zika: Vector competence and 12 £101,995 Sinkins University interactions with Wolbachia ZK/16-023 London School of Zika: Cohort study of pregnant Laura Hygiene and women with rash in 18 £112,361 Rodrigues Tropical Medicine Pernambuco State Zika: Novel point-of-care ZK/16-025 Liverpool School molecular diagnostics for the Luis E of Tropical simultaneous diagnosis of Zika, 18 £150,000 Cuevas Medicine chikungunya and dengue infections in Latin America Zika: susceptibility of South ZK/16-041 Matthew University of American and European vectors 18 £116,615 Bayliss Liverpool to ZIKV infection, and influence of temperature Zika: Zika in Colombia: ZK/16-045 Neil M.
    [Show full text]
  • ORGANISATION/COMPANY Institutions Across Europe in the Bactivax ITN European Training Network RESEARCH FIELD Biological Sciences
    Institutions across Europe in the BactiVax ITN ORGANISATION/COMPANY European Training Network RESEARCH FIELD Biological sciences; Medical sciences RESEARCHER PROFILE Early/First Stage Researcher (R1) APPLICATION DEADLINE 31st December 2019, 17:00 GMT START DATE On or before 1st April 2020 LOCATION Multiple locations, see partner institutions below TYPE OF CONTRACT Temporary JOB STATUS Full-time HOURS PER WEEK 36 – 40 EU RESEARCH FRAMEWORK H2020 / Marie Skłodowska-Curie Actions PROGRAMME MARIE CURIE GRANT AGREEMENT 860325 NUMBER Applications are invited for 15 three-year PhD studentships to be funded by the Marie- Skłodowska-Curie Innovative Training Network “BactiVax” within the Horizon 2020 Programme of the European Commission. BactiVax (anti-Bacterial Innovative Vaccines) is an innovative European Training Network that will provide high-level training in vaccinology to 15 high-achieving, creative Early Stage Researchers (ESRs), and equip them with a wide range of transferrable skills for thriving careers in vaccine research within academia and industry. BactiVax will focus on developing novel vaccines to tackle the huge challenge of antimicrobial-resistant human pathogens that cause chronic, life-threatening respiratory and/or systemic infections. This network comprises 14 Principal Investigators with expertise in vaccinology, proteomics, medicine, microbiology, biochemistry, immunology, structural biology, medicinal, peptide and glycochemistry from 8 European countries and two companies which will collectively train ESRs in entrepreneurship, commercial vaccine development and bioprocessing. Participant organisations and principal investigators • University College Dublin (UCD, Dublin, Ireland) - Assoc. Prof. Siobhán McClean (2 positions) • National Research Council, Institute of Biostructures and Bioimaging (CNR-IBB, Naples, Italy) - Dr. Rita Berisio 1 • Queens University Belfast (QUB, Belfast, UK) – Prof.
    [Show full text]
  • Prior SARS-Cov-2 Infection Rescues B and T Cell Responses to Variants After First Vaccine 30 April 2021
    Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine 30 April 2021 dose, potentially leaving them at risk from variants. Professor Rosemary Boyton, Professor of Immunology and Respiratory Medicine at Imperial College London, who led the research, said: "Our findings show that people who have had their first dose of vaccine, and who have not previously been infected with SARS-CoV-2, are not fully protected against the circulating variants of concern. This study highlights the importance of getting second doses of the vaccine rolled out to protect the population." Blood samples were analyzed for the presence and Colorized scanning electron micrograph of a dying cell levels of immunity against the original strain of (blue) heavily infected with SARS-CoV-2 (yellow), the SARS-CoV-2, as well as the Kent (B.1.1.7) and virus that causes COVID-19. Credit: NIAID Integrated South Africa (B.1.351) variants of concern. Along Research Facility, Fort Detrick, Maryland. with antibodies—the Y-shaped proteins which stick to the virus and help block or neutralize the threat—the researchers also focused on two types of white blood cell: B-cells, which 'remember' the A single dose of vaccine boosts protection against virus; and T cells, which help B cell memory and SARS-CoV-2 coronavirus variants, but only in recognize and destroy cells infected with those with previous COVID-19, a study has found. coronavirus. In those who have not previously been infected They found that after a first dose of vaccine, prior and have so far only received one dose of vaccine infection was associated with a boosted T cell, B the immune response to variants of concern may cell and neutralizing antibody response, which be insufficient.
    [Show full text]
  • Reynolds Et Al Manuscript Text Final 09.10.2020
    medRxiv preprint doi: https://doi.org/10.1101/2020.10.13.20211763; this version posted October 14, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . 1 Healthcare workers with mild / asymptomatic SARS-CoV-2 infection show T cell 2 responses and neutralising antibodies after the first wave 3 4 5 Catherine J. Reynolds1,15, Leo Swadling2,15, Joseph M. Gibbons3,15, Corinna Pade3,15, 6 Melanie P. Jensen4, Mariana O. Diniz2, Nathalie M. Schmidt2, David Butler1, Oliver E. Amin2, 7 Sasha N. L. Bailey1, Stephen Taylor5, Jessica Jones5, Meleri Jones3,6, Wing-Yiu Jason Lee3, 8 Joshua Rosenheim2, Aneesh Chandran2, George Joy4, Cecilia Di Genova7, Nigel 9 Temperton7, Jonathan Lambourne8, Teresa Cutino-Moguel9, Mervyn Andiapen4, Marianna 10 Fontana10, Angelique Smit10, Amanda Semper5, Ben O’Brien4,11,12, Benjamin Chain2, Tim 11 Brooks5, Charlotte Manisty4,13, Thomas Treibel4,13, James C Moon4,13, COVIDsortium 12 investigators, Mahdad Noursadeghi2, COVIDsortium immune correlates network, Daniel M. 13 Altmann14,16, Mala K. Maini2,16, Aine McKnight3,16, Rosemary J. Boyton1,15,16,* 14 15 16 15These authors contributed equally. 16Joint senior authors 17 1Department of Infectious Disease, Imperial College London, London, UK 18 2Division of Infection and Immunity, University College London, London, UK 19 3Blizard Institute, Barts and the London School of Medicine
    [Show full text]
  • British Thoracic Society Winter Meeting 2010
    Thorax: first published as 10.1136/thx.2010.150896.scientificprogram on 15 December 2010. Downloaded from PROGRAMME AND ABSTRACTS Thorax British Thoracic Society Winter Meeting 2010 The Queen Elizabeth II Conference Centre copyright. Broad Sanctuary Westminster London SW1P 3EE 1 to 3 December 2010 http://thorax.bmj.com/ Programme and Abstracts on September 27, 2021 by guest. Protected ii Thorax 2010;65(Suppl IV) Map to QEII Conference Centre Thorax: first published as 10.1136/thx.2010.150896.scientificprogram on 15 December 2010. Downloaded from PowerPoint preview facilities will be available throughout the three days of the Meeting in the Thames Room on the fi rst fl oor of the Centre. All presenters and chairs should report to the Speakers’ section of the Registration Desks on arrival. copyright. http://thorax.bmj.com/ on September 27, 2021 by guest. Protected Thorax 2010;65(Suppl IV) iii QEII Conference Centre – Ground and First Floors Thorax: first published as 10.1136/thx.2010.150896.scientificprogram on 15 December 2010. Downloaded from Fire Exit Fire Exit tix GROUND FLOOR eriF E Stage o o m Churchill Auditorium r k a olC Stairs to Pickwick Suite and Thames Room Telephones Fire Exit Fire Exit Telephones BTS RECEPTION Toilets Lifts Lifts Toilets Sanctuary Foyer Toilets Telephones Main Entrance copyright. Fire Exit Fire Exit t xE er xE i Fi Toilets Thames stel Room i o VOID T http://thorax.bmj.com/ FIRST FLOOR Fire Exit Churchill Auditorium Gallery Fire Exit Telephones Catering Lift Lifts T e l e p h o n e s on September 27, 2021 by guest.
    [Show full text]
  • Long-Term Exposure to Interleukin-8, Lung Remodelling and Altered T Cell
    Long-term exposure to interleukin-8, lung remodelling and altered T cell immunity in the context of chronic infection with Pseudomonas aeruginosa in chronic lung disease. Kathryn Jane Quigley A thesis submitted for the degree of Doctor of Philosophy Lung Immunology Group Infectious Diseases and Immunity Department of Medicine Imperial College London August 2014 1 Declaration I hereby declare that the research submitted in this thesis is my own and describes my own work under the supervision of Dr. Rosemary Boyton, at the Department of Medicine, Imperial College, except where the work of others has been acknowledged at the point of use. All sources of information have been appropriately cited and accompanied with a full list of references. Copyright Declaration ‘The copyright of this thesis rests with the author and is made available under a Creative Commons Attribution Non-Commercial No Derivatives licence. Researchers are free to copy, distribute or transmit the thesis on the condition that they attribute it, that they do not use it for commercial purposes and that they do not alter, transform or build upon it. For any reuse or redistribution, researchers must make clear to others the licence terms of this work.’ 2 Abstract In the lung, the fine balance between an appropriate immune response that defends against incoming pathogens while avoiding excessive inflammation leading to collateral tissue damage is dependent on appropriate and effective immune regulation. Lung disease can result in situations where the balance is tipped and excessive or inappropriate inflammation results in acute or chronic lung damage and impaired lung function. This is the case in non-CF bronchiectasis where enhanced inflammation and chronic lung infection are associated with irreversible tissue damage.
    [Show full text]
  • Project Trific 1 Deep Immuno-Profiling of Aspergillus
    Project TrIFIC 1 Deep immuno-profiling of Aspergillus bronchitis and allergic bronchopulmonary aspergillosis in cystic fibrosis Applications are invited for a Cystic Fibrosis Trust funded 3-year PhD studentship. This studentship is integral to a major Strategic Research Centre in Fungal Immunotherapy (TrIFIC) made to Imperial College London collaborating with the University of Manchester, University of Exeter, University of Massachusetts and Radboud University Nijmegen. The overall aim of the SRC is to systematically define the underlying mechanisms of inflammation in pulmonary aspergillosis in the context of cystic fibrosis. This will enable development of immuno-diagnostic tests to identify which patients will benefit from targeted immunotherapies that can be repurposed in CF-related fungal disease. We are seeking a highly motivated student to join the opportunistic pathogens group led by Dr Darius Armstrong-James within the MRC Centre for Molecular Bacteriology and Infection within the Faculty of Medicine of Imperial College London at the South Kensington Campus. The project is in collaboration with Professor Stuart Elborn (Queen’s Belfast), Professor Rosemary Boyton (Imperial College London), and Professor Frank van der Veerdonk (University of Nijnmegen, the Netherlands) The aim of the project is to undertake deep immunoprofiling of the host response to the major mould pathogen Aspergillus fumigatus in patients with allergic bronchopulmonary aspergillosis and Aspergillus bronchitis. This will allow us to identify those individuals who will have poor outcomes from infection and develop novel targeted immuno-therapeutic approaches for fungal disease. The outstanding international supervisory panel will allow the student the opportunity to be exposed to a range of cutting-edge immunoprofiling techniques for human disease pathogenesis and translational immunotherapy.
    [Show full text]
  • T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia Pseudomallei: a Correlate of Disease Outcome in Acute Melioidosis
    The Journal of Immunology T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis Catherine Reynolds,* Ame´lie Goudet,† Kemajittra Jenjaroen,‡ Manutsanun Sumonwiriya,‡ Darawan Rinchai,x Julie Musson,{ Saskia Overbeek,* Julia Makinde,* Kathryn Quigley,* Jiten Manji,* Natasha Spink,‖ Pagnarith Yos,# Vanaporn Wuthiekanun,‡ Gregory Bancroft,‖ John Robinson,{ Ganjana Lertmemongkolchai,x Susanna Dunachie,‡,** Bernard Maillere,† Matthew Holden,†† Daniel Altmann,* and Rosemary Boyton* There is an urgent need for a better understanding of adaptive immunity to Burkholderia pseudomallei, the causative agent of melioidosis that is frequently associated with sepsis or death in patients in Southeast Asia and Northern Australia. The imperative to identify vaccine targets is driven both by the public health agenda in these regions and biological threat concerns. In several intracellular bacterial pathogens, alkyl hydroperoxidase reductases are upregulated as part of the response to host oxidative stress, and they can stimulate strong adaptive immunity. We show that alkyl hydroperoxidase reductase (AhpC) of B. pseudomallei is strongly immunogenic for T cells of ‘humanized’ HLA transgenic mice and seropositive human donors. Some T cell epitopes, such as p6, are able to bind diverse HLA class II heterodimers and stimulate strong T cell immunity in mice and humans. Importantly, patients with acute melioidosis who survive infection show stronger T cell responses to AhpC relative to those who do not. Although the sequence of AhpC is virtually invariant among global B. pseudomallei clinical isolates, a Cambodian isolate varies only in C-terminal truncation of the p6 T cell epitope, raising the possibility of selection by host immunity.
    [Show full text]