DOCSLIB.ORG

Postoperative Adjuvant Treatment of Invasive Malignant Mammary Gland Tumors in Dogs with Doxorubicin and Docetaxel

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Postoperative Adjuvant Treatment of Invasive Malignant Mammary Gland Tumors in Dogs with Doxorubicin and Docetaxel J Vet Intern Med 2006;20:1184–1190 Postoperative Adjuvant Treatment of Invasive Malignant Mammary Gland Tumors in Dogs with Doxorubicin and Docetaxel Daniela Simon, Dorina Schoenrock, Wolfgang Baumga¨rtner, and Ingo Nolte Background: Treatment outcome after surgery alone is unsatisfactory in dogs with invasive malignant mammary gland tumors. Hypothesis: Adjuvant doxorubicin or docetaxel will improve the treatment outcome in dogs with high-risk malignant mammary gland tumors, and the use of docetaxel will be feasible in affected dogs. Animals: Thirty-one dogs with malignant mammary gland tumors of histologic stages II and III (vascular or lymphatic invasion, regional lymph node metastasis, or distant metastasis) were used. Methods: A prospective clinical trial in which dogs were treated with surgery alone (n 5 19) or also received adjuvant chemotherapy (n 5 12) with doxorubicin or docetaxel was conducted. Docetaxel was given as an IV infusion at a dose of 30 mg/m2 preceded by dexamethasone and diphenhydramine administration. Results: The recurrence-free interval ranged from 13 to 2,585 days (median not reached); the median metastasis-free interval and overall survival were 294 days and 370 days, respectively. Dogs treated with chemotherapy had a tendency toward higher long-term local control and survival rates, but there was no significant difference in the recurrence-free interval (P 5 .17), time to metastasis (P 5 .71), and overall survival (P 5 .12). Factors found to influence the time to metastasis and overall survival included lymph node metastasis (P 5 .009) and tumor fixation to underlying structures (P 5 .043, time to metastasis), as well as age (P 5 .018) and histologic stage (P , .001, survival). Mild allergic skin reactions were the most frequently observed complications of docetaxel treatment. Conclusions and Clinical Importance: Chemotherapy did not lead to an improved outcome in this population. Docetaxel treatment was well tolerated. Additional investigations of adjuvant chemotherapy in dogs with high-risk mammary cancer are warranted. Key words: Cancer; Canine; Chemotherapy; Mammary carcinoma; Prognosis. ammary tumors are among most frequent tumor efficacy, therefore, are of importance in dogs with high- M types in female dogs.1,2 Because of the protective risk mammary cancer. effect of early neutering, the incidence of canine Preclinical studies have documented the antitumor mammary tumors has decreased markedly in the United activity of doxorubicin and carboplatin in canine States,2,3 however, mammary tumors still are frequently malignant mammary tumor cultures and of cyclophos- encountered in unspayed female dogs, especially in phamide, cisplatin, and 5-fluoruracil in canine mamma- Europe.4–7 ry tumor xenografts in severe combined immunodefi- Surgical excision alone yields unsatisfactory results in ciency mice.10,11 Adjuvant chemotherapy is routinely dogs with malignant mammary tumors exhibiting used in women with breast cancer, however, only limited lymphatic or vascular invasion because these tumors information is available on the efficacy of postoperative have high rates of recurrence and metastasis.8,9 It has chemotherapy in dogs. been revealed that within a 2-year period after surgical Recently, a veterinary study was reported in which excision, dogs with invasive mammary tumors have a 13- adjuvant chemotherapy with 5-fluoruracil and cyclo- fold increased risk of recurrence as compared to those phosphamide improved patient survival in comparison with noninvasive disease.8 The development of adjuvant to dogs treated with surgery alone.12 Also, the efficacy of treatments and the investigation of their antineoplastic doxorubicin chemotherapy for inducing partial remis- sions of pulmonary metastases in dogs with mammary tumors has been documented in case reports.13,14 From the Department of Small Animal Medicine and Surgery In human medicine, the anthracycline doxorubicin is (Simon, Schoenrock, Nolte), and Department for Pathology one of the most effective and frequently used chemo- (Baumga¨rtner), University of Veterinary Medicine, Hannover, therapeutic agents in first-line adjuvant treatment of Germany. Presented in part at the 19th Annual Veterinary Cancer mammary carcinoma.15,16 The taxanes are inhibitors of Society Conference, Woods Hole, MA, November 13–16, 1999, and 17 the 14th European College of Veterinary Internal Medicine- microtubule disassembly that result in mitotic arrest. Companion Animals Congress, Barcelona, Spain, September 9–11, Paclitaxel and docetaxel have established efficacy in the 18 2004, and published as an abstract in J Vet Intern Med 2004;18:790– treatment of mammary tumors in humans. Docetaxel 791. has been approved for the treatment of metastatic breast Reprint requests: Daniela Simon, Dr.med.vet. Dipl., ECVIM-CA cancer since 1996, and there is increasing evidence for its (Internal Medicine & Oncology), Department of Small Animal beneficial effect in the treatment of early mammary Medicine and Surgery, University of Veterinary Medicine Hannover, carcinoma.18–21 Taxanes, however, are not routinely used Bischofsholer Damm 15, D-30173 Hannover, Germany; e-mail: in veterinary oncology. One report describes the in- [email protected]. duction of partial remissions in 2 dogs with macroscopic Submitted January 4, 2006; Revised February 24, 2006; Accepted March 28, 2006. mammary tumors after treatment with paclitaxel, but the overall toxicity was high.22 To the authors’ Copyright E 2006 by the American College of Veterinary Internal Medicine knowledge, docetaxel has not been used for the 0891-6640/06/2005-0019/$3.00/0 treatment of tumors in dogs. The dose of 30 mg/m2 Chemotherapy in Canine Malignant Mammary Tumors 1185 used in this study was derived from preclinical studies in Follow-Up Examinations Beagle dogs.17 In these studies, the highest nonlethal Follow-up examinations were scheduled at 6 weeks and 3, 6, 9, 2 toxic dose was found to be 30 mg/m IV. Dose-limiting 12, 18, 24, and 48 months after completion of chemotherapy in toxicity in these preclinical studies was gastrointestinal groups II and III. Dogs in the control group were scheduled for re- and hemotologic in nature. examination at the same time points after surgery. Follow-up The aim of this study was to investigate the efficacy of examination included physical examination, CBC, serum bio- adjuvant, postoperative doxorubicin and docetaxel chemistry profile, and thoracic radiographs. If indicated by treatment in dogs with high-risk, invasive malignant abnormalities on physical examination, blood work or radio- mammary tumors in comparison to surgery alone. In graphs, an abdominal ultrasound, an ECG, and an echocardio- addition, it was the aim of this study to document gram were performed. Local recurrence was defined as a recurrent tolerance and toxicity of docetaxel in dogs with cancer. mass at the surgery site with confirmation by cytology or histology in cases in which owners gave their consent. In cases in which cytologic or histologic confirmation was not possible, any mass Materials and Methods developing at the surgery site was considered a recurrence. Patient Inclusion Criteria Cytologic examination, histologic examination, or both of meta- static lesions was performed if possible. Postmortem examination Dogs with mammary tumors were eligible for the study if they was performed in cases in which owners gave their consent. fulfilled the following criteria: (1) surgical excision of the mammary tumors by radical mastectomy or partial mastectomy, depending on Statistical Analysis tumor number and distribution in the mammary chain, (2) a clinical tumor stage I–IV (see the Appendix),23 (3) histologic confirmation of Endpoints that were evaluated included local recurrence, distant malignancy in at least 1 tumor, and (4) histologic confirmation of at metastasis, and overall survival. The recurrence-free interval was least 1 malignant stage II or III tumor (see the Appendix).8 defined as the time from surgery to tumor recurrence in the surgical Additional inclusion criteria were no chemotherapy or radiation field. The metastasis-free interval was defined as the time from therapy before the study, no other serious medical illness that would surgery to the detection of distant metastasis as documented on limit full compliance with the study, and signed owner consent. thoracic radiographs, abdominal ultrasound, or both. Overall survival was defined as time from surgery to death from any cause. Pretreatment Evaluation Kaplan-Meier product limit analysis was used for recurrence- free interval, metastasis-free interval, and overall survival analyses. Dogs underwent complete clinical staging consisting of patient Dogs were censored if their tumor had not recurred (recurrence- history, physical examination, documentation of tumor size and free interval analysis) or no distant metastases had been detected characteristics, CBC, serum biochemistry profile, thoracic radio- (metastasis-free interval analysis) at time of death or data accrual graphs (right and left lateral, ventrodorsal), abdominal radiographs closure. (lateral), abdominal ultrasound, ECG, and an echocardiogram, if In the survival analysis, dogs were censored if they were alive at indicated. Mammary tumors and regional lymph nodes were the time of data accrual closure. In those dogs in which measured directly with calipers or by ultrasonographic imaging. postmortem examination was not performed, determination of whether the cause of death was tumor-related
Load more

Recommended publications
  • The Snf1-Related Kinase, Hunk, Is Essential for Mammary Tumor Metastasis
    The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis Gerald B. W. Wertheima, Thomas W. Yanga, Tien-chi Pana, Anna Ramnea, Zhandong Liua, Heather P. Gardnera, Katherine D. Dugana, Petra Kristelb, Bas Kreikeb, Marc J. van de Vijverb, Robert D. Cardiffc, Carol Reynoldsd, and Lewis A. Chodosha,1 aDepartments of Cancer Biology, Cell and Developmental Biology, and Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160; bDepartment of Diagnostic Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; cCenter for Comparative Medicine, University of California, County Road 98 and Hutchison Drive, Davis, CA 95616; and dDivision of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905 Communicated by Craig B. Thompson, University of Pennsylvania, Philadelphia, PA, July 27, 2009 (received for review April 22, 2009) We previously identified a SNF1/AMPK-related protein kinase, Hunk, Results from a mammary tumor arising in an MMTV-neu transgenic mouse. Hunk Is Overexpressed in Aggressive Subsets of Human Cancers. To The function of this kinase is unknown. Using targeted deletion in investigate its role in human tumorigenesis, we cloned the human mice, we now demonstrate that Hunk is required for the metastasis homologue of Hunk from a fetal brain cDNA library. Sequence of c-myc-induced mammary tumors, but is dispensable for normal analysis yielded a composite cDNA spanning an ORF of 714 amino development. Reconstitution experiments revealed that Hunk is suf- acids (GenBank accession #NM࿝014586). Review of this sequence ficient to restore the metastatic potential of Hunk-deficient tumor and of human genome data indicated that a single Hunk isoform cells, as well as defects in migration and invasion, and does so in a exists that is 92% identical to murine Hunk at the amino acid level manner that requires its kinase activity.
    [Show full text]
  • Surgically-Induced Multi-Organ Metastasis in an Orthotopic Syngeneic Imageable Model of 4T1 Murine Breast Cancer
    ANTICANCER RESEARCH 35: 4641-4646 (2015) Surgically-Induced Multi-organ Metastasis in an Orthotopic Syngeneic Imageable Model of 4T1 Murine Breast Cancer YONG ZHANG1, NAN ZHANG1, ROBERT M. HOFFMAN1,2 and MING ZHAO1 1AntiCancer, Inc., San Diego, CA, U.S.A.; 2Department of Surgery, University of California, San Diego, CA, U.S.A. Abstract. Background/Aim: Murine models of breast cancer When implanted orthotopically, 4T1 has been shown to with a metastatic pattern similar to clinical breast cancer in metastasize to organs similarly to clinical breast cancer in humans would be useful for drug discovery and mechanistic humans, including to lungs, liver, brain and bone (3-6). Tao studies. The 4T1 mouse breast cancer cell line was developed et al. transformed the 4T1 cell line to express luciferase for by Miller et al. in the early 1980s to study tumor metastatic longitudinal detection of primary growth and metastases (7). heterogeneity. The aim of the present study was to develop a In their study, metastasis at high rates, including the lungs, multi-organ-metastasis imageable model of 4T1. Materials and liver and bone, occurred in most animals within six weeks Methods: A stable 4T1 clone highly-expressing red fluorescent with lower frequency of metastasis to brain and other sites. protein (RFP) was injected orthotopically into the right second This imageable model is limited by the weak signal of mammary fat pad of BALB/c mice. The primary tumor was luciferase which requires photon-counting of anesthetized resected on day 18 after tumor implantation, when the average animals. The weak signal of luciferase cannot produce a true tumor volume reached approximately 500-600 mm3.
    [Show full text]
  • Canine Mammary Carcinoma
    Oncology Services Lloyd Veterinary Medical Center Hixson-Lied Small Animal Hospital Canine Mammary Carcinoma What is a canine mammary carcinoma? Tumors of the mammary gland develop when the cells associated with the mammary gland become cancerous and grow uncontrollably. In dogs, approximately 50% of mammary tumors are malignant (have the potential to spread to other areas of the body). The other half are considered to be benign. The most common type of malignant mammary tumor is a carcinoma. What are the clinical signs of a mammary tumor? This tumor is often identified during a routine physical exam, or you may notice it at home. They usually manifest as a swelling of the mammary gland or the nearby tissues/skin. They can be firm or soft. How is a mammary tumor diagnosed? Biopsy is required to diagnose a mammary gland tumor. Prior to making definitive treatment options, full staging with an abdominal ultrasound, chest x-rays, and evaluation of the local lymph nodes are recommended to look for any spread of disease. How is a mammary tumor treated? Treatment of mammary tumors is aimed at both local control (removing the primary tumor and minimizing the likelihood of local recurrence) and systemic control (delaying the onset of spread of disease). Each tumor should be removed with a wide band of normal tissue around the tumor to result in the best possible outcome. If this type of surgery is not possible, a combination of surgery and radiation therapy may be discussed. Based on the type of tumor, and several factors evaluated on biopsy, chemotherapy may be recommended in addition to surgical removal.
    [Show full text]
  • Suppression Ofautochthonous Grafts Ofspontaneous Mammary Tumor by Induced Allogeneic Graft Rejection Mechanism
    [CANCER RESEARCH 33, 645-647, April 1973] Suppression of Autochthonous Grafts of Spontaneous Mammary Tumor by Induced Allogeneic Graft Rejection Mechanism Reiko Tokuzen and Waro Nakahara National Cancer Center Research Institute, Tsukiji 5-chome, Chuo-ku, Tokyo, Japan SUMMARY existing between the allogeneic and autochthonous grafts are involved in determining the different susceptibilities to the Autochthonous grafts of spontaneous mammary adenocar- host-mediated antitumor effect of plant polysaccharides. cinoma of mice give 100% takes with no spontaneous More recently, we examined local cellular reactions around regression. However, the growth of these autografts was Sarcoma 180 grafts during the process of regression under markedly inhibited with a high rate of complete regression polysaccharide treatment, and we found a massive outpouring when the grafts were mixed with ascitic Sarcoma 180 and of lymphoid cells 1 week after tumor implantation. No such implanted under i.p. treatment with lentinan. Lentinan is one cellular reaction was noted in untreated controls or in mice of the so-called antitumor-active plant polysaccharides; it treated with inactive polysaccharides. Similarly, autoch strongly inhibits Sarcoma 180 but has no effect on thonous grafts of spontaneous mammary tumors, not at all autochthonous grafts. Without the lentinan treatment, the inhibited by polysaccharides, called forth no local lymphoid mixed autografts and Sarcoma 180 or Sarcoma 180 alone cell infiltration. constantly produced large tumors. These results indicate that a The question arose as to what would happen to autoch local rejection mechanism against allogeneic tumor (Sarcoma thonous grafts if such local cell reaction were induced around 180), induced by injections of lentinan, failed to recognize them as in that which occurred around Sarcoma 180 under autografts as "self and destroyed them along with the polysaccharide treatment.
    [Show full text]
  • Understanding the Etiology of Inflammatory Breast
    UNDERSTANDING THE ETIOLOGY OF INFLAMMATORY BREAST CANCER by Lauren M. Shuman A thesis submitted to the Faculty of the University of Delaware in partial fulfillment of the requirements for the degree of Master of Science in Biological Sciences Spring 2015 © 2015 Lauren M. Shuman All Rights Reserved ProQuest Number: 1596894 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. ProQuest 1596894 Published by ProQuest LLC (2015). Copyright of the Dissertation is held by the Author. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code Microform Edition © ProQuest LLC. ProQuest LLC. 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, MI 48106 - 1346 UNDERSTANDING THE ETIOLOGY OF INFLAMMATORY BREAST CANCER by Lauren M. Shuman Approved: ____________________________________________________ Kenneth L. van Golen, Ph.D. Professor in charge of thesis on behalf of the Advisory Committee Approved: ____________________________________________________ Robin W. Morgan, Ph.D. Chair of the Department of Biological Sciences Approved: ____________________________________________________ George H. Watson, Ph.D. Dean of the College of Arts and Sciences Approved: ____________________________________________________ James G. Richards, Ph.D. Vice Provost for Graduate and Professional Education ACKNOWLEDGMENTS First and foremost, I would like to thank Dr. Kenneth van Golen for a list of things, but namely for the opportunity to work in this lab that gave me my first experience in cancer research.
    [Show full text]
  • Control of Mammary Tumor Differentiation by SKI-606 (Bosutinib)
    Oncogene (2011) 30, 301–312 & 2011 Macmillan Publishers Limited All rights reserved 0950-9232/11 www.nature.com/onc ORIGINAL ARTICLE Control of mammary tumor differentiation by SKI-606 (bosutinib) L Hebbard1,7,9, G Cecena1,7, J Golas2,8, J Sawada3,7, LG Ellies4, A Charbono1,7, R Williams1,7, RE Jimenez5, M Wankell1,7, KT Arndt2,8, SQ DeJoy2,8, RA Rollins2,8, V Diesl2,8, M Follettie2,8, LChen2,8, E Rosfjord2,8, RD Cardiff6, M Komatsu3,7, F Boschelli2,8 and RG Oshima1,7 1Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA; 2Center for Integrative Biology and Biotherapeutics, Pfizer Research, Pearl River, NY, USA; 3Sanford-Burnham Medical Research Institute, Lake Nona, FL, USA; 4Pathology Department, University of California, San Diego, CA, USA; 5Biomedical Science Program, University of California, San Diego, La Jolla, CA, USA and 6Center for Genomic Pathology University of California, Davis, CA, USA C-Src is infrequently mutated in human cancers but it Introduction mediates oncogenic signals of many activated growth factor receptors and thus remains a key target for cancer In breast cancer, Src is of particular interest as it is therapy. However, the broad function of Src in many cell activated by both steroid hormone receptors and ErbB types and processes requires evaluation of Src-targeted family growth factor receptors and activates transcrip- therapeutics within a normal developmental and immune- tion factors such as STAT3, STAT5 and b-catenin by competent environment. In an effort to understand the direct phosphorylation (Silva and Shupnik, 2007; Kim appropriate clinical use of Src inhibitors, we tested an Src et al., 2009).
    [Show full text]
  • Clinicopathological Diversity of Canine Mammary Gland Tumors in Sri Lanka: a One-Year Survey on Cases Presented to Two Veterinary Practices
    veterinary sciences Article Clinicopathological Diversity of Canine Mammary Gland Tumors in Sri Lanka: A One-Year Survey on Cases Presented to Two Veterinary Practices Harsha Ariyarathna 1, Niranjala de Silva 2, Danielle Aberdein 1, Dayananda Kodikara 3, Manjula Jayasinghe 2, Ranjith Adikari 2 and John S. Munday 1,* 1 School of Veterinary Science, Massey University, Palmerston North 4442, New Zealand; [email protected] (H.A.); [email protected] (D.A.) 2 Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya 20400, Sri Lanka; [email protected] (N.d.S.); [email protected] (M.J.); [email protected] (R.A.) 3 New Animal Clinic, 132/B, S. De. S. Jayasinghe Mawatha, Kohuwala, Nugegoda 10250, Sri Lanka; [email protected] * Correspondence: [email protected]; Tel.: +64-6-356-9099 (ext. 85172) Received: 19 February 2018; Accepted: 24 April 2018; Published: 27 April 2018 Abstract: Mammary gland tumors (MGTs) are one of the most common neoplasms among dogs in Sri Lanka. However, the clinicopathological diversity of MGTs in Sri Lanka is largely unknown, impeding accurate diagnosis and effective treatment of the disease. The present study investigated the clinicopathological features of MGTs in 74 dogs presented to two veterinary practices in Sri Lanka treated surgically, over a one-year period. Information regarding the patient signalment, clinical presentation, and reproductive history were collected, and each neoplasm was examined histologically. Forty-one (54.4%) dogs were primarily presented for mammary neoplasia, while a MGT was an incidental finding in 33 (44.6%) dogs. The majority of tumors were histologically malignant (n = 65, 87.8%), and 18 malignant tumor sub-types were identified.
    [Show full text]
  • Inflammatory Breast Cancer: the Immune Perspective
    The Texas Medical Center Library DigitalCommons@TMC The University of Texas MD Anderson Cancer Center UTHealth Graduate School of The University of Texas MD Anderson Cancer Biomedical Sciences Dissertations and Theses Center UTHealth Graduate School of (Open Access) Biomedical Sciences 5-2013 Inflammatory Breast Cancer: The Immune Perspective Evan N. Cohen Follow this and additional works at: https://digitalcommons.library.tmc.edu/utgsbs_dissertations Part of the Immunity Commons, and the Medical Sciences Commons Recommended Citation Cohen, Evan N., "Inflammatory Breast Cancer: The Immune Perspective" (2013). The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access). 369. https://digitalcommons.library.tmc.edu/utgsbs_dissertations/369 This Dissertation (PhD) is brought to you for free and open access by the The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at DigitalCommons@TMC. It has been accepted for inclusion in The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access) by an authorized administrator of DigitalCommons@TMC. For more information, please contact [email protected]. Inflammatory Breast Cancer: The Immune Perspective by Evan Nathaniel Cohen, B.S., B.A. APPROVED:!!!! ______________________________! James M. Reuben, Ph.D., M.B.A. Supervisory Professor ______________________________! Bradley McIntyre, Ph.D. ______________________________!
    [Show full text]
  • Electrochemotherapy Modulates Mammary Tumor Growth in Rats on a Western Diet Supplemented with Curcumin
    biomedicines Article Electrochemotherapy Modulates Mammary Tumor Growth in Rats on a Western Diet Supplemented with Curcumin Raji Sundararajan 1,*, Lakshya Mittal 1 and Ignacio G. Camarillo 2,3 1 School of Engineering Technology, Purdue University, West Lafayette, IN 47907, USA; [email protected] 2 Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA; [email protected] 3 Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA * Correspondence: [email protected] Received: 25 September 2020; Accepted: 10 November 2020; Published: 13 November 2020 Abstract: In the US, every 12 min, six women are diagnosed with breast cancer and one dies. This highlights a critical need for developing alternate therapies using natural compounds, which are cost effective and with less side effects. Curcumin, the yellow pigment of turmeric has been found to suppress initiation, progression, and metastasis of a variety of tumors. Multiple clinical trials highlight the efficacy of curcumin in treating breast cancer and other diseases. Our in vitro studies have demonstrated that the electrical pulse (EP) application can further enhance the effectiveness of curcumin against breast cancer cells in a therapy called electrochemotherapy (ECT). In a direct extension of these results, we studied the effect of ECT coupled with intratumoral curcumin administration (EP+Cur) on N-methyl-N-nitrosourea (MNU) induced mammary tumors in female Sprague Dawley rats. Beginning at the weaning and throughout the study, rats were fed either western diet (West) or western diet, supplemented with 1% curcumin (W+Cur). Our results showed that EP+Cur treatment led to a reduced growth rate in rats fed with W+Cur diet compared to West diet (57.14% vs.
    [Show full text]
  • Spontaneous Malignant Mixed Tumors of the Rat, and the Successful Transplantation and Separation of Both Components from a Mammary Tumor Wilhelmina F
    Spontaneous Malignant Mixed Tumors of the Rat, and the Successful Transplantation and Separation of both Components from a Mammary Tumor Wilhelmina F. Dunning, Ph.D., Maynie R. Curtis, Ph.D.,* and Mark E. Maun, M.D. (Department o/ Pathology, Wayne University College o/ Medicine in co-operation with the Detroit Institute o/ Cancer Research, Detroit 26, Michigan) (Received for publication June 1, 1945) Malignant mixed tumors in man are relatively rare, comas and 1 a mixed tumor. Loeb (14) reported the but their occurrence has occasioned considerable dis- transplantation of an adenocarcinoma of the sub- cussion of their probable histogenesis. In 1937, Raso maxillary gland of a mouse, which developed into (16) reported an osteoid chondrosarcoma of the breast mixed tumors and spindle cell sarcomas in the first and collected from the literature, dating from 1835, transplanted generation. A transplantable mixed tumor 74 mammary tumors containing bone and cartilage, of the fowl was reported by Foulds (10). The primary but only 5 were considered to be true mixed tumors. growth, which appeared to be a carcinoma of the ovi- Saphir and Vass (17), in 1938, reviewed 153 cases of duct, was transplanted for 12 generations with varying "carcinosarcoma," excluding any tumors containing success into the pectoral muscles of fowls of the same large amounts of cartilage and bone that might be in- and different breeds. Bone and cartilage were found terpreted as teratomas. They concluded from the mor- in growths of the first and succeeding generations of phology of these neoplasms that in all but 3 or 4 cases transplantation.
    [Show full text]
  • Mammary Tumours in Dogs and Its Treatment Option- a Review
    Review Article ISSN: 2574 -1241 DOI: 10.26717/BJSTR.2020.30.004980 Mammary Tumours in Dogs and its Treatment Option- A Review Haben Fesseha* Haben Fesseha, School of Veterinary Medicine, Wolaita Sodo University, Ethiopia *Corresponding author: Haben Fesseha, School of Veterinary Medicine, Wolaita Sodo University, Ethiopia ARTICLE INFO ABSTRACT Received: September 11, 2020 Mammary tumors are the most common type of tumors in intact female dogs. Several epidemiologic studies have been conducted over the years and provide an estimate of Published: September 22, 2020 the incidence of canine mammary gland tumors. This type of treatment recommendation may also be made in dogs based on recognized, well-accepted prognostic factors such as tumor size, stage, type, and histologic differentiation. Based on the limited clinical Citation: Haben Fesseha. Mammary information available in veterinary medicine, the drugs that are effective in human breast Tumours in Dogs and its Treatment Option- A Review. Biomed J Sci & Tech Res in the treatment of malignant mammary gland tumors in dogs. The treatment of canine 30(4)-2020. BJSTR. MS.ID.004980. mammarycancer, such gland as cyclophosphamide, tumors will be based 5-fluorouracil, on the individual and doxorubicin, oncologist’s may understanding also have a role of Keywords: Neoplasm; Tumor Disease; Hyperplastic Lesions; Mammary Adenoma; tumor biology, experience, interpretation of the available studies, and a little bit of gut- Fibrothecoma; Glandular Epithelium chemotherapy in dogs with high-risk mammary
    [Show full text]
  • Pursuing Drugs for Mammary Cancer So You Want to Add One More Caot?
    ® Expert information on medicine, behavior and health from a world leader in veterinary medicine 'Tail Vaccinations Save Lives' 2 Pursuing Drugs for Mammary Cancer New research finds that they make it easier to deal with sarcomas. Cornell researchers identify an inhibitor that seems to The Power ofTouch 2 Stroking anxious shelter cats can kill cancer cells while leaving healthy cells unaffected ease their stress and increase immunity. How to Handle a Fainting Episode 3 n esearchers studying feline Baker Institute for Animal Health, An immediate veterinary visit is a ftmammary cancer at Cornell have identified a promising chemical, must to uncover the underlying cause. University College of Veterinary BB-CI-amidine, that seems to kill off Should Their (at Drink Milk? 8 Medicine have set an ambitious feline mammary cancer cells while They may love it, but it offers few agenda. They hope that their leaving healthy cells unaffected. benefits and some potential harm. ongoing work will lead to better diagnosis. treatment and preven­ Malignant Tumors. The chemi­ IN THE NEWS ••• tion of breast tumors in cats and cal inhibits certain enzymes, Raising Awareness About humans. Much of their interest called peptidylarginine deimi­ Obesity's Risks and Solutions lies in how a novel class of drugs nase (PAD), which tend to be Despite the potential con­ affects breast cell tumors. over expressed (increased) in sequences of obesity, up to 59 In a study funded by the Cor­ feline mammary tumors. The percent of cats are overweight, nell Feline Health Center. As­ ~- majority 0 f t hese tumors are .2> according to the American sistant Professor Gerlinde Van '" malignant, and they're the Anima l Hospital Association.
    [Show full text]