Therapeutic Advances in Gastroenterology: TAG-19-04-084.R3.

TITLE OF ARTICLE: Efficacy and Safety of Adalimumab in Chinese Patients With Moderately to Severely Active Crohn’s Disease: Results From a Randomized Trial

Ethics Committee sites and approval numbers

Investigator Name Site Name/Post Office Address Name and Address of IEC/IRB IEC Approval number Chen, Minhu The First Affiliated Hospital Ethics Committee for Clinical Sun-Yat Sen University drug, Equipment and New Medical 2015-013-01 Department of Gastroenterology Technology of The First Affiliated No.58 Zhong Shan Er Rd, Guangzhou Hospital; Sun-Yat Sen University , 510080 Room110,F1, Office building, Longzhu Mansion, No.5, Zhu Si Gang Er Ma Lu GUANGZHOU, AN Guangdong Province 510080 China Chen, Yan The Second Affiliated Hospital of Ethics Committee for Human University School of Medicine Research of Second Affiliated 2015-118 Gastroenterology Outpatient Department Hospital Rm.1601 School of Medicine 9th Building,3rd Floor,Rm.304 Rm. 1601, Building 9, No. 88 No.88 Jiefang Rd Jiefang Road Zhejiang HANGZHOU, AN Zhejiang Province Province, 310009 310009 China China Dai, Ning Sir Hospital Sir Run Run Shaw Hospital, the Zhejiang University School of Medicine, Zhejiang University School of 20150623-5 Department of Gastroenterology office Medicine Rm.208 EC office, No. 3 East Qingchun Rd, 2nd loor of laundry building HANGZHOU, AN 310016 No. 3 East Qing Chun Rd China HANGZHOU, AN Zhejiang Province 310016 P.R. China Fan, Jiangao Xinhua Hospital Affiliated to Xinhua Hospital Affiliated to Jiao Tong University School of Medicine Shanghai Jiao Tong University XHEC-A-2015-023-2 Department of Gastroenterology School of Medicine No.1665 Kongjiang Rd, No.1665 Kongjiang Rd SHANGHAI, AN 200092 SHANGHAI, AN 200092 China China

Gao, Xiang The Sixth Affiliated Hospital of Sun Yatsen Ethics Committee of The Sixth University Affiliated Hospital of Sun Yat-sen 2015ZSLYEC-010 Department of Gastroenterology University No.26 Yuan Cun Er Heng Rd, Tianhe No. 26 Yuan Cun Er Heng Rd, District Tianhe District GUANGZHOU, GUANGDONG, GUANGZHOU, AN Guangdong 510655 Province 510655 China China

Liu, Deliang The Second Xiangya Hospital of Central The Second Xiangya Hospital of South University 2015-EC-080 No.139 People's Road F4, Pharmacy Building Province No. 139 Renmim Rd CHANGSHA, 410011 CHANGSHA, 410011 China Hunan Province China

Liu, Side Nanfang Hospital Ethics Committee for Medicine of Southern Medical University Nanfang Hospital, Southern NFEC-2015-058 Department of Gastroenterology Medical University No. 1838 North Guangzhou Ave, 1838 Guangzhou North Ave Guangdong Province GUANGZHOU, AN 510000 GUANGZHOU CITY, 510515 Guangdong Province China China

Liu, Zhanju Shanghai Tenth People's Hospital Shanghai Tenth People's Hospital Department of Gastroenterology 2nd Floor, No.3 Building SHSY-IEC-3.0/15-49/01 No. 301, Middle Yanchang Rd No.301 Yanchang Middle Rd SHANGHAI, AN 200072 SHANGHAI, AN 200072 China China

Ren, Jianlin Zhongshan Hospital Medical Ethic Committee of Department of Gastroenterology Zhongshan Hospital Xiamen 2015-EC-20 No. 201-209 Hubin South Rd, University Province Pharmaceutical Department at the XIAMEN, AN 361004 2nd Fl, The 1st Building, No. 201- China 209 Hubin South Road, Xiamen, Fujian Province 361004, P.R. China

Sheng, Jianqiu The Army General Hospital, PLA Clinical Trial Ethics Committee of No. 5 Nanmencang, Dongsishitiao, the Army General Hospital , PLA BZEC2015-YW-007 Dongcheng District No. 5 Nanmencang, Dongsishitiao, , 100700 Dongcheng District, Beijing, China 100700, China Tang, Chengwei West China Hospital, University Ethics Committee for Clinical Trial (Replaced by No.37 Guo xue Xiang Chengdu 510041 and Biomedicine of West China 2015-EC-47 Wang, Yufang) Sichuan Province Hospital China Rm.412, Old 8th Teaching Building, No.37 Guc Xue Xiang, Chengdu 610041 Sichuan Province, China Tian, Dean Tongji Hospital Tongji Medical college Clinical Trial Ethics Committee Huazhong University of Science and of Huazhong University of 2015-ER-100 Technology Science and Technology No.13 Department of Gastroenterology Hangkong Rd No. 1095 Jiefang Rd, Province Hubei Province , 430030 WUHAN, 430030 China China Wang, Huahong First Hospital Peking University First Hospital No. 8 Xishiku St, Xicheng District No.6 Dahongluochang Street, 2015-18 (Site did not enroll) BEIJING, 100034 Xicheng District China BEIJING, 100034 China Wu, Kaichun The First Affiliated Hospital of IEC, First Affiliated Hospital of Fourth Military Medical, PLA Fourth Military Medical University YS20150729-4 F9, Gastroenterology Building F20, Gastroenterology Building, No. 127 West Chang Le Rd, No.127 West Province Chang Le Road, X'ian, Shaannxi XI'AN, 7100032 Province, 710032 China China Zhong, Jie Ruijin Hospital, Shanghai Jiaotong Ruijin Hospital, Shanghai Jiaotong University School of Medicine University School of Medicine 2015-48 Department of Gastroenterology No. 197 Ruijin Er Rd No. 197, Rui Jin Er Rd SHANGHAI, AN 200025 SHANGHAI, AN 200025 China China Zhu, Xuan The First Affiliated Hospital of The First Affiliated Hospital of Nanchang University 2015-EC-13 Department of Gastroenterology F8, Outpatient Building No. 17, Yongwaizheng St, No.17 Yongwaizheng St Province NANCHANG, 330006 NANCHANG, 330006 Jiangxi Province, China China