Supplemental Table 1.

Mesenchymal and invasion related gene expression changes NSC11 U87

Gene Description Fold Change Gene Description Fold Change chitinase 3-like 1 (cartilage glycoprotein- CHI3L1 7.527 CXCR4 chemokine (C-X-C motif) receptor 4 4.997 39) CXCL10 chemokine (C-X-C motif) ligand 10 4.636 DKK1 dickkopf homolog 1 (Xenopus laevis) 3.074 GTP binding protein overexpressed in GEM 4.186 ESM1 endothelial cell-specific molecule 1 3.013 skeletal muscle A2M alpha-2-macroglobulin 3.481 ITGA6 integrin, alpha 6 2.543 guanylate binding protein 1, interferon- GBP1 3.435 RGS4 regulator of G-protein signaling 4 2.082 inducible CTSS cathepsin S 2.857

CLU clusterin 2.795

VEGFA vascular endothelial growth factor A 2.627 zinc finger and BTB domain containing ZBTB16 2.54 16 GDF15 growth differentiation factor 15 2.518

ADAM9 ADAM metallopeptidase domain 9 2.434

RND3 Rho family GTPase 3 2.405

HMOX1 heme oxygenase (decycling) 1 2.361

Angiogenic and inflammatory gene expression changes

NSC11 U87

Gene Description Fold Change Gene Description Fold Change

CXCL11 chemokine (C-X-C motif) ligand 11 6.355 CXCR4 chemokine (C-X-C motif) receptor 4 4.997 major histocompatibility complex, class TNFRSF1 tumor necrosis factor receptor HLA-DRA 6.204 3.355 II, DR alpha 1B superfamily, member 11b CXCL10 chemokine (C-X-C motif) ligand 10 4.636 DKK1 dickkopf homolog 1 (Xenopus laevis) 3.074 HLA- major histocompatibility complex, class triggering receptor expressed on 4.322 TREM1 3.037 DRB1 II, DR beta 1 myeloid cells 1 GTP binding protein overexpressed in progestagen-associated endometrial GEM 4.186 PAEP 2.961 skeletal muscle protein retinoic acid receptor responder HLA- major histocompatibility complex, class RARRES3 3.694 2.645 (tazarotene induced) 3 DQA1 II, DQ alpha 1 major histocompatibility complex, class HLA-DMA 3.442 CCL24 chemokine (C-C motif) ligand 24 2.626 II, DM alpha Cadherin, Cadherin (E,N,P,VE), guanylate binding protein 1, interferon- CDH5 2.366 GBP1 3.435 CTNNA-CTNNB1-CTNNG-CDH5 inducible HOXA13 homeobox A13 2.297 APOL3 apolipoprotein L, 3 3.38 c-fos induced growth factor (vascular FIGF 2.238 endothelial growth factor D) CFB complement factor B 2.959 FBJ murine osteosarcoma viral FOS 2.958 oncogene homolog CTSS cathepsin S 2.857 bone morphogenetic protein receptor, BMPR1A 2.808 type IA CD74 molecule, major CD74 2.792 histocompatibility complex, class II ITK IL2-inducible T-cell kinase 2.74