ADCY 5/6 (A V, A Cyclase VI, Adenylate Cyclase Type 5, ATP pyrophosphate- 5, Adenylate Cyclase Type V, 5, ADCY5, Adenylate Cyclase Type 6, ATP pyrophosphate-Lyase 6, Adenylate Cyclase Type VI, Adenylyl Cyclase 6, Ca(2+)-inhibitable adenylyl Cyclase, ADCY6, KIAA0422)

Catalog number 220593 Supplier United States Biological

A cyclase V, also known as ADCY5, is a 1,261 amino acid Adenylyl cyclase that localizes to cellular membranes and contains two domains. Similar to other A cyclase proteins, A cyclase V uses magnesium as a to catalyze the conversion of ATP to cAMP. A cyclase VI, also known as ADCY6 (adenylate cyclase type 6), is a 1,168 amino acid A cyclase that localizes to the membrane and contains two guanylate cyclase domains. Using magnesium as a cofactor, A cyclase VI functions as a calcium-inhibitable A cyclase that catalyzes the conversion of ATP to 3',5'-cyclic AMP and diphosphate and plays a role in a variety of events throughout the body. Multiple isoforms of A cyclase VI exist due to alternative splicing events. Applications Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry. Other applications not tested. Recommended Dilution Western Blot: 1:500-1:1000 Immunohistochemistry: 1:50-1:200 Immunofluorescence: 1:50-1:200 Optimal dilutions to be determined by the researcher. Storage and Stability May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Immunogen Synthetic peptide corresponding to amino acids 1111-1160 of Human ADCY 5 Formulation Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2. Purity Purified by immunoaffinity chromatography. Specificity Recognizes endogenous levels of ADCY 5/6. Species Crossreactivity: Human, mouse, rat Product Type Pab Source human Isotype IgG Grade Affinity Purified Applications IF IHC WB Crossreactivity Hu Mo Rt Storage -20°C MW 130139

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