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Scientific Documentation Gut Dysbiosis Scientific Documentation Gut Dysbiosis, Immune Dysregulation and their Impact on Children’s Health 1. Michael Camilleri, “Serotonin in the gastrointestinal tract,” Current Opinion in Endocrinology, Diabetes and Obesity 16, no. 1 (February 2009): 53-59. 2. IN Pessah et al., “Immunologic and neurdevelopmental susceptibilities of autism,” Neurotoxicology 29, no. 3 (May 2008): 532-45; 3. PH Patterson, “Immune involvement in schizophrenia and autism: Etiology, pathology and animal models,” Behavioural Brain Research 24 (Dec 2008). 4. Roland Tisch et al., “Dysregulation of T cell peripheral tolerance in type 1 diabetes,” Advances in Immunology 100 (2008): 125-149. 5. C.A. Edwards and A. M. Parrett, “Intestinal flora during the first months of life: new perspectives,” British Journal of Nutrition 88 (2002): S11-S18. 6. A. Borchers et al., “Probiotics and immunity,” Journal of Gastroenterology 44 (2009): 26-46. 7. UG Strauch et al., “Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis,” Gut 54 (2005):1546-1552. 8. Tomas Hrncir et al., “Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice,” BMC Immunology 9 (2008): 65 9. Hiroaki Kitano and Kanae Oda, “Robustness trade-offs and host-microbial symbiosis in the immune system,” Molecular Systems Biology 2 (2006). 10. Hannah Wexler, “Bacteroides: the Good, the Bad, and the Nitty-Gritty,” Clinical Microbiology Reviews 20, no. 4 (October 2007): 593-621. 11. Ann M. O’Hara and Fergus Shanahan, “The gut flora as a forgotten organ,” European Molecular Biology Organization Report 7, no 7 (July 2006): 688-693. 12. Jessica Snyder Sachs, Good Germs, Bad Germs: Health and Survival in a Bacterial World (New York: Hill and Wang, 2007). 13. Patrick Hanaway MD, "Balance of Flora, GALT, and Mucosal Integrity," Alternative Therapies in Health and Medicine 12, no. 5 (September/October 2006). 14. Leo Galland, MD,“The Effect of Intestinal Microbes on Systemic Immunity,” Excerpted from Power Healing (New York: Random House, 1998) http://mdheal.org/microbes.htm (accessed February 12, 2009). 15. G. Oliveira et al., “Mitochondrial dysfunction in autism spectrum disorders: a population-based study,” Developmental Medicine and Child Neurology 47 (2005): 185-189. 16. Z. Liu et al., “Tight junctions, leaky intestines, and pediatric diseases,” Acta Paediatricia 94 (2005): 386-393. 17. J.W. Bennett and M. Klich, “Mycotoxins,” Clinical Microbiology Reviews (July 2003): 497-516. 18. Yoshinori Mine and Jie Wie Zhang, “Surfactants Enhance the Tight-Junction Permeability of Food Allergens in Human Intestinal Epithelial Caco-2 Cells,” International Archives of Allergy and Immunology 130, no. 2 (Feb 2003) 19. Simon Smale and Ingvar Bjarnason, “Determining small bowel integrity following drug treatment,” British Journal of Clinical Pharmacology 56, no. 3 (September 2003): 284-291 20. Ruchika Mohan et al., “Effects of Bifidobacterium lactis Bb12 Supplementation on Intestinal Microbiota of Preterm Infants: A Double-Blind, Placebo-Controlled, Randomized Study,” Journal of Clinical Microbiology 44, no. 11 (November 2006): 4025-4031. 21. Samuli Rautava and Erika Isolauri, “The Development of Gut Immune Responses and Gut Microbiota: Effects of Probiotics in Prevention and Treatment of Allergic Disease,” Current Issues in Intestinal Microbiology 3 (2002): 15-22. 22. F. Savino, “Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study,” Pediatrics 119, no. 1 (January 2007): e124-30. 23. Erica White and Caroline Sherlock, “The Effect of Nutritional Therapy for Yeast Infection (Candidiasis) in Cases of Chronic Fatigue Syndrome,” Journal of Orthomolecular Medicine 20, no. 3 (2005). 24. Natasha Campbell-McBride, Gut and Psychology Syndrome (Cambridge: Medinform Publishing, 2004). 25. Cedars-Sinai Medical Center, "Birth Control Pill: Oral Contraceptive Use May Be Safe, But Information Gaps Remain," ScienceDaily, January 17, 2009, http://www.sciencedaily.com/releases/2009/01/090114092848.htm (accessed February 26, 2009). 26. Randall Fitzgerald, The Hundred-Year Lie (London: Plume, 2007). 27. Joanne K. Tobacman, “Review of Harmful Gastrointestinal Effects of Carrageenan in Animal Experiments,” Environmental Health Perspectives 109, no 10 (October 2001). 28. Gail Hecht, “Microbial Pathogens That Affect Tight Junctions,” in Tight Junctions (New York: CRC Press, 2001): 493-515. 29. Dr. Robyn Cosford, “Occult Infections, Streptococcus, Biofilms, PANDAS and MINDDD in Autism,” (lecture, Defeat Autism Now! Conference, San Diego, CA, October 2008). 30. Lindsey A. Moser et al., “Astrovirus Increases Epithelial Barrier Permeability Independently of Viral Replication,” Journal of Virology 81, no. 21 (November 2007). 31. RC Bransfield et al., “The association between tick-borne infections, Lyme borreliosis and autism spectrum disorders," Medical Hypotheses 70, no. 5 (November 2007): 967-74. 32. Mark. A. Hyman, M.D, “Is the Cure for Brain Disorders Outside the Brain?” Alternative Therapies in Health and Medicine 13, no. 6 (November/December 2007): 6. 33. Mark Jackson, Allergy: The History of a Modern Malady (London: Reaktion Books, 2007). 34. Katrina J. Allen, David J. Hill and Ralf G. Heine, “Food Allergy in Childhood,” Medical Journal of Australia 185, no 7 (October 2006). 35. William Walsh, Food Allergies: The Complete Guide to Understanding and Relieving Your Food Allergies (Hoboken, NJ: Wiley John and Sons Inc, 2000): 3. 36. E. Isolauri, S.Rautava, and M. Kalliomaki, “Food allergy in irritable bowel syndrome: new facts and old fallacies,” Gut 53, no. 10 (October 2004): 1391- 1393. 37. C. Vael et al., “Early intestinal Bacteroides fragilis colonization and development of asthma,” BMC Pulmonary Medicine 8 (September 2008): 19. 38. Nariman Hijazi, Bahaa Abalkhail, and Anthony Seaton, “Diet and childhood asthma in a society in transition: A study in urban and rural Saudi Arabia,” Thorax 55, no. 9 (2000): 775-779. 39. CR Morris and MC Agin, “Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation,” Alternative Therapies in Health and Medicine 15, no. 4 (July-August 2009): 34-43. 40. Bryan Jepson, MD, “Conference Presentations: Bryan Jepson, MD,” Thoughtful House Center for Children, http://www.thoughtfulhouse.org/0405-conf- bjepson.htm, (accessed July 20, 2009). 41. Lynn Waterhouse, “Autism Overflows: Increasing Prevalence and Proliferating Theories,” Neuropsychology Review 18 (November 2008): 273-286. 42. Mark Hyman MD, "Autism: Is It All in the Head?" Alternative Therapies in Health and Medicine 14, no. 6 (November/December 2008): 12-15. 43. Hans Rediers et al., “Unraveling the Secret Lives of Bacteria: Use of In Vivo Expression Technology and Differential Fluorescence Induction Promoter Traps as Tools for Exploring Niche-Specific Gene Expression,” Microbiology and Molecular Biology Reviews 69, no. 2 (June 2005): 217-261. 44. Dr. Arthur Krigsman, “Gastrointestinal Pathology in Autism: Description and Treatment,” Thoughtful House Center for Children, paper adapted from a presentation (2000), http://www.thoughtfulhouse.org/0405-conf-akrigsman.htm (accessed March 18, 2009). 45. Dr. Margaret Bauman, “The Autism Spectrum Disorders: Beyond Behavior— Research and Treatment Implications,” (lecture, UC Davis M.I.N.D. Institute, Distinguished Lecturer Series, Sacramento, CA, January 11, 2006) http://www.ucdmc.ucdavis.edu/mindinstitute/events/dls_recorded_events.html#dl s08. (accessed, January 21, 2009). 46. Karoly Horvath et al., “Gastrointestinal abnormalities in children with autistic disorder,” Journal of Pediatrics 135, no. 5 (November 1999): 559-63. 47. Karoly Horvath and JA Perman, “Autistic disorder and gastrointestinal disease,” Current Opinion in Pediatrics 14, no. 5 (October 2002): 583-7. 48. Craig A. Erickson et al., “Gastrointestinal Factors in Autistic Disorder: A Critical Review,” Journal of Autism and Developmental Disorders 35, no. 6, (December 2005). 49. Dr. Andrew Wakefield, “The Seat of the Soul; The Origins of the Autism Epidemic,” (lecture, Carnegie Mellon University, Pittsburgh, PA, November 17, 2005, Thoughtful House Center for Children, http://www.thoughtfulhouse.org/awakefield_1105.pdf (accessed March 6, 2009). 50. Some of Dr. Wakefield’s research is available at: http://www.thoughtfulhouse.org/publications.htm (accessed March 7, 2009). 51. B Thjodleifsson et al., “Effect of Pentavac and measles-mumps-rubella (MMR) vaccination on the intestine,” Gut 51, no. 6 (December 2002): 816-7. 52. Massimo Montalto et al, “Fecal Calprotectin Concentrations in Patients with Small Intestinal Bacterial Overgrowth,” Digestive Diseases 26, no. 2 (April 2008): 183-186. 53. L. Shi et al., “Activation of the maternal immune system alters cerebellar development in the offspring,” Brain, Behavior, and Immunity 23, no. 1 (January 2009): 116-23. 54. C. Winter et al., “Dopamine and serotonin levels following prenatal viral infection in mouse—implications for psychiatric disorders such as schizophrenia and autism,” European Neuropsychopharmacology 18, no. 10 (October 2008): 712-6. 55. GL Nicolson et al., “Evidence for Mycoplasma ssp., Chlamydia pneumoniae, and human herpes virus-6 coinfections in the blood of patients with autistic spectrum disorders,” Journal of Neuroscience Research 85, no. 5 (April 2007): 1143-8. 56. K Lancaster
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