2016 Vol.1 azbil Group PR magazine

Moving Ahead To Expand Business Overseas Amari Watergate Bangkok Focusing on Safe, Reliable, Proven, and Durable Technologies

- Special Feature Cognicise

the aging of population is accelerating. The most advanced medical care and Particularly important is to gain A coined term combining "cognition" and "exercise." This exercise program is designed to simulate the brain function by promoting thinking while exercising. Needless to say, healthy understanding of the aging process. lifestyle with proper daily diet, ample sleep, and adequate exercise is also very important. research taking on the challenge of Spearheading those efforts is the National Institute for Longevity Sciences-Longitudi- Multi-stepping ever-increasing dementia nal Study of Aging (NILS-LSA) conducted by NCGG. The main objectives of NILS-LSA are to The discover the causes of aging and genera- Estimated number of people number of dementia patients tion of geriatric diseases such as demen- with dementia in Japan is forecast to exceed seven tia, osteoporosis, and presbycusis and to ？ million in 2025. This means one out of every develop methods to prevent them. To five people aged 65 and over will suffer from those ends, not only medical profession- dementia. The National Center for Geriatrics and 1 Stamp rhythmically. 1 Stamp by moving the stamping foot in the als but also specialists in a broad range following order: right foot forward, left foot Gerontology (NCGG) is a leader in the research and ？ of fields including psychology, kinematics, 2 Clap hands once forward, right foot to right, and left foot to left. treatment of dementia in Japan. NCGG's advanced every three times. 2 Clap hands once every three times. dementia research and treatment efforts and activities, and nutrition science are collecting and million 7 such as a collaborative medical approach transcending analyzing data pertaining to aging. 4.62 the boundaries of professions and departments and In 1997, an NILS-LSA survey began with million long-term, large-scale research activities, are randomly selecting 2,300 local residents with various medical departments in the participants to think while moving the body. attention from the world over as of both sexes aged between 40 and 79. hospital to provide seamless medical treat- It is expected to help prevent dementia they form the basis of the longevity Once every two years, detailed full-day ment and healthcare to patients from the and improve the symptoms of mild in 2012 in 2025 country that is Japan. medical examinations were conducted to time they were diagnosed with dementia to cognitive impairment (MCI) before the One out of every check more than 1,000 items, including a the terminal phase. onset of overt dementia. nutrition survey, psychographic survey, Needless to say, the Center is focused Establishing a system to help five people aged 65 and motor function tests. This large-scale on maintaining the healthy brain function survey project ended in 2012, and it led to of patients. In addition to this, it pays close dementia patients live and over will have the announcement of more than 600 attention to physical diseases, vital func- comfortably in their familiar What is dementia? surroundings dementia in research results. tions, behavioral and psychological symp- Dementia is caused by damage to brain cells that occurs for some For instance, one of the survey results toms of dementia (BPSD), and alleviation To enable people with dementia and their reason and results in the loss or degradation of their functions. De- ten years' time?! mentia decreases the ability to think and remember, thus affecting indicated that the intake of an appropriate of the burden on caregivers. Reducing the families to continue living in areas familiar Source : Ministry of Health, Labour and Welfare, a New Orange a person's daily functioning. Because curative treatment methods Plan document (Preliminary figures reported in “A Study on the have not been developed as yet except for a very few symptoms, amount of DHA, which is contained burden on caregivers is especially impor- to them, proper diagnosis and treatment at Projection of the Elderly Population with Dementia in Japan” by alleviation of symptoms or suppression of progress are the purposes Toshiharu Ninomiya M.D., Ph.D., Kyushu University, conducted densely in blueback fish oil, might help tant because if caregivers become exces- the early stage of dementia is essential. To as a Special Research funded by the FY2014 Health and La- of present treatment and medical care for people with dementia. bour Sciences Research Grants) prevent the decline of cognitive function sively tired from working too hard, they will that end, the Japanese government has in both men and women. A two-year not be able to provide effective care for initiated a program to develop and foster follow-up survey conducted with people of dementia patients. The Center regularly dementia support doctors. Dementia middle and old age showed that people holds classes for families of dementia support doctors not only diagnose and who read books in their free time had patients and provides them with opportuni- treat dementia but also respond to Japan's approach to dementia ity science, gerontology, and geriatrics. The Research Institute, on the other higher capabilities to accumulate abilities ties to learn about dementia and various consultations from patients' private doctors care attracts great attention NCGG is composed of the National hand, promotes advanced research stemming from knowledge or experience stages of dementia development. and care workers and provide cooperation from all over the world Hospital for Geriatric Medicine and the activities to elucidate mechanisms of and to adapt to new issues. The Center is also aggressively to them, and also conduct awareness Research Institute. The National Hospital aging and geriatric generation, develop addressing the prevention of dementia. raising activities such as holding of Seamless medical service NCGG is a world-leading medical and for Geriatric Medicine addresses the and apply new diagnostic methods and Degradation of muscle strength leads to a seminars for local residents. The Japanese from first medical examination research institution in the fields of longev- treatment of diseases particularly preva- treatment techniques, and promote decline of cognitive function, although their government aims to increase the number to terminal care lent in older people and developments in the geriatric and relationship has not been clearly identified of dementia support doctors to 5,000 by also strives to establish gerontologic engineering (nursing The Center for Comprehensive Care and yet. When the cognitive function decreas- the end of 2017. model cases of dementia robots and others) field. Research on Memory Disorders estab- es, the person tends to stay home and the Such a regional collaborative system patient nursing care, re- lished by NCGG became a model case of amount of bodily movements reduces. This formed with dementia support doctors at gional home healthcare co- Seeking causes of geriatric a realistic medical setting in Japan and further degrades the muscle strength, thus the core can be seen in no other operation, and terminal diseases and developing has drawn a great deal of attention. The falling into a vicious circle. In view of this, countries in the world. Thus, the initiative care, with its sights set on preventive care Center provides long-term medical treat- NCGG encourages people to actively ex- taken in Japan can be a model case for the standardization of treat- Japan is faced with an urgent need to ment and social care through interprofes- ercise for the prevention of dementia. One other Asian countries where the popula- ments in the future. advance the medical and nursing care as sional collaboration of doctors, nurses, of such exercises is called "cognicise." tion is also aging quickly. European pharmacists, nursing care staff, social This exercise program is designed to countries and the United States are also

The National Center for Geriatrics and Gerontology (NCGG) workers, and others. It also collaborates stimulate brain activities by promoting showing great interest in this system.

2 2016 Vol. 1 2016 Vol. 1 3 Case Study Amari Watergate Bangkok

An ACTIVAL control valve with flow measurement controls PARAMATRIX III optimizes the operation of chillers. Calorimeters for monitoring the operating status of 4 chillers. the flow rate of the air-conditioning cooling water.

with abundant experience in the automation ating the hotel as usual with no changes on ing about implementing energy-saving mea- industry. We were relieved to hear that Azbil the surface, but in actuality we are saving a sures at its other hotels in Thailand. Azbil was put in charge of implementing the BEMS great amount of energy,” Mr. Srisanit explains. provides us with considerable support in and HVAC control, because these systems managing the renovated systems, and I ex- Whole-building energy consumption cut by 15 %, were an essential part of the renovations,” resulting in large reduction in power costs pect that Azbil will continue to provide reliable says Mr. Srisanit. support for our future endeavors in energy Renovation work began in the latter half Since the energy-saving measures were imple- conservation,” says Mr. Srisanit. of 2011. Despite the considerable effects mented, the energy consumption of the whole The Amari Watergate Bangkok hotel is located in a downtown area called Pratunam in Bangkok, the cap- from the flood that hit Thailand in the fall of building has been reduced by about 15 %. This ital city of Thailand. The hotel was selected for a model energy conservation project proposed by a that year, the entire renovation project was reduction is equivalent to about 700 kiloliters Japanese company. It has implemented a series of energy-saving measures, including a BEMS, and as a completed in March 2012. of oil consumption per year. “We spent result of optimal air-conditioning and heat source equipment operation it has saved a large amount of Azbil installed its savic-netTMFX building 4,500,000 THB (approx. US $128,000) for Amari Watergate Bangkok energy. The system implemented at the hotel has also made it possible to visualize energy perfor- management system as the BEMS. Working electricity every month before the project, but mance. The hotel now receives much attention as a leading example of energy efficiency in Thailand. together with equipment such as the PARA- that has now been reduced to 3,300,000 THB MATRIXTMIII digital controller for the heat (approx. US $94,000). I am very satisfied with sources and ACTIVALTM control valve with this result,” says Mr. Srisanit. Chosen for a Japanese company’s mod- In 2009, the Chugoku Electric Power Co., gy-saving measures to be implemented for flow measurement, savic-net FX accumu- The effects of the energy-saving measures el project, Amari Watergate Bangkok Inc. (Chugoku EPCO), a Japanese firm, drew the facility in areas such as air-conditioning, lates data and stores it in the PARACON- implemented at the hotel have attracted at- redoubled its energy-saving measures up an energy-saving plan for Thailand in co- hot water supply, and lighting, and selected DUCTORTM heat source optimization control- tention as one of the leading examples of operation with the Metropolitan Electricity Au- Japanese manufacturers for each area. Azbil ler. The building management system green technology in Thailand, which is com- Amari Watergate Bangkok, a five-star hotel, thority (MEA), a Thai company supplying Corporation and its local affiliate, Azbil (Thai- provides easily understandable visual data mitted to nationwide energy conservation. opened in 1994 in Thailand’s capital city of power to the capital city area, and submitted land) Co., Ltd., were selected to install the on the operating status of all air-conditioning The hotel offers walk-through tours of its fa- Location 2 Bangkok, and is conspicuously situated in a the plan to a competitive subsidy program ar- BEMS and the controllers for air-condition- and heat source equipment. This allows com- cilities, such as the air-conditioning system 847 Petchburi Road, Bangkok, Thailand 34-story modern building on Petchburi Road, ranged by NEDO. 1 The plan was accepted, ing and heat source equipment. As the only parison of the figures obtained before and and the central control room where the BEMS Founded which is lined with shopping malls. In addition and after examining the possibilities for im- Japanese company that has a local office in after implementation of the energy-saving is installed. Many people who are interested 1994 Business to the view of the city from its luxurious plementation, Chugoku EPCO selected Ama- Thailand and provides solutions in the area of measures, so the amount of energy saved by in energy conservation and who work for gov- Hotel, restaurants, fitness center, etc. rooms, the hotel provides various facilities ri Watergate Bangkok as its Thai recipient energy conservation for buildings, Azbil has each piece of equipment is now clear. ernment agencies, educational organiza- such as restaurants and a fitness center. company because of its enthusiasm for en- proven its performance through one-stop pro- Variable speed drives were added to the tions, and commercial facilities such as ho- Many foreigners who visit Bangkok for sight- ergy efficiency. The hotel was judged to have vision of a range of services including design, water condenser pumps and coolant pumps tels and shopping malls have taken the tour. seeing and business purposes choose to the potential for large energy savings. construction/renovation, and maintenance. in order to control the flow rate and conse- Amari Watergate Bangkok is moving for- Udom Srisanit stay at the hotel. NEDO is pushing forward with its project of “I have known about Azbil for quite some quently to optimize the amount of power con- ward with better equipment management for Engineering Director Today, Thailand is faced with a skyrocketing supporting the implementation of energy- sav- time, because it is a Japanese manufacturer sumption. They were also added to the cool- saving even more energy by analyzing data demand for electricity as its economy contin- ing measures in foreign nations in order to ing tower fans in order to keep their power that is “visualized” and stored by the BEMS. ues to grow. It is imperative for the nation to promote Japanese “green” technologies consumption to a minimum in accordance “Amari Hotels & Resorts Group is also think- find ways to use energy efficiently, and so around the world. For participants in the proj- with the operation of the chillers. Amari Watergate Bangkok is also making ef- ect, NEDO entirely covers the equipment “Our hotel operates 24 hours a day, 365 forts to save energy, with both cost reduction costs necessary for implementation, with the days a year, so we had to be particularly care- glossary and environmental policy in mind. “We have facility owner paying only the construction and ful in renovating the air-conditioning system, 1sNEDO New Energy and Industrial Technology Development Organiza- always taken measures like adding thermal renovation costs. Therefore, the plan was since it has much to do with a comfortable tion. This is a Japanese government R&D organization promot- insulation film to the hotel windows and intro- very attractive to Amari Watergate Bangkok. guest experience. Renovations were complet- ing the development of new energy sources and industrial tech- nologies. ducing a water recycling system and cleaning ed without a single guest complaint, thanks to 2sBEMS Hotel remains open during renovations, Building and energy management system. A BEMS uses automation system for the air-conditioning cooling tower,” Azbil’s thorough planning and thoughtful con- technology to monitor and control power consumption for facilities with no guest complaints such as buildings, factories, and district heating and cooling facili- explains Udom Srisanit, engineering director Azbil installed savic-net FX in the central control room as the sideration, which were what we expected The heat source machine room has been modified for ties, to minimize the power consumption for the whole facility. BEMS. Operating status and the amount of energy use for the tours. Guests can learn about the energy-saving mea- at the hotel. Chugoku EPCO determined the specific ener- heat source equipment can now be checked at a glance. from a Japanese company. We are now oper- sures by observing equipment like chillers and pumps.

savic-net, savic-net FX, PARACONDUCTOR, PARAMATRIX, and ACTIVAL are trademarks of Azbil Corporation. 4 2016 Vol. 1 2016 Vol. 1 5 Jiangsu Yangli Group Co., Ltd. Yangzhou Metalforming Co., Ltd.

vol.21 Moving Ahead To Expand Business Overseas Focusing on Safe, Reliable, Proven, and Durable Technologies General Manager Lin Ya Jie (left) and Azbil TA’s President and CEO Chief Executive Pan Yun Hu (right) and Azbil TA’s President and CEO Masashi Hirano Masashi Hirano

Azbil TA Co., Ltd. provides pneumatic components, such as lubrication units that incorporate advanced fluid control technology, dual valves, and high-performance regulators. The company has a large market share in China, specifically in the field of dual valves, which are an essential part of the machine presses that shape metallic parts and products. Growing by means of close partnership with local companies, Azbil TA is aiming at even further growth of its business in overseas markets.

Azbil TA’s dual valve in the JF21 Series press Azbil TA’s dual valve in the JB36 Series straight side press

Dual valves are used in presses as a di- headquartered in Yangzhou City in the Success in the Chinese dual-valve market Jiangsu Yangli Group Co., Ltd. de- Yangzhou Metalforming Machine results from support for production, reli- rectional control valve to start and stop the province of Jiangsu in eastern China. velops a variety of mechanical Tool Co., Ltd. provides mechanical ability, and safety of machine presses air clutch and brake. Azbil TA’s products The Jiangsu Yangli Group was estab- presses for the automotive, house- presses mainly in the automotive and are highly rated for reliability and play a lished in 1996 and has five fully owned or hold appliance, and semiconductor household appliance areas. Its press- uided by its philosophy of “hu- role in ensuring safety where press work is holding divisions: Yangli Machine Tools industries. Its products are used in es for making air conditioner panels China and other nations in South have an especially large share of the man-centered automation,” the done. Co., Ltd., Yangli Heavy Duty Machine America and Southeast Asia.“We market.“Using high-quality compo- azbil Group is developing the Ad- The company started doing business in Tools Co., Ltd., Yangli Precision Machine G are planning to expand our market Lin Ya Jie nents to make a product will increase Pan Yun Hu vanced Automation business in the plant East Asia when its dual valves were cho- Tools Co., Ltd., Yangli CNC Machine share abroad. To do so, we need to General Manager the value of the product itself. Azbil Chief Executive and factory markets, and also the Bulding sen by a leading press manufacturer Tools Co., Ltd., and Yangli Hydraulic Ma- make products with high added Director TA provides us with high-quality Automation and Life Automation business. headquartered in Taiwan. At that time Chi- chine Tools Co., Ltd. It is a major enter- value. Azbil TA’s dual valves have valves and services that satisfy our good quality and we already have a expectations. With the help of Azbil As a part of the Advanced Automation na was undergoing rapid economic prise that deals in machines for , good relationship, so we are look- TA, we intend to enhance the value business, Azbil TA Co., Ltd. plays an im- growth, and in line with that growth, the shearing, bending, and as its ing forward to even better products of our products and develop our busi- portant role as a company with expertise demand for machine presses was increas- flagship products, and is aiming to be- and services,” says Mr. Lin. ness overseas,” says Mr. Pan. in manufacturing pneumatic devices. ing. When a Chinese manufacturer known come “a 100-year company” and a global The company was founded in 1955. for its emphasis on safety and research on brand. Yangzhou Metalforming Machine Jiangsu Yangli Group Yangzhou Metalforming Based on the advanced fluid control tech- various kinds of safety devices chose Az- Tool, on the other hand, is a well-estab- Co., Ltd. Machine Tool Co., Ltd. nologies it has cultivated through 60 years bil TA’s dual valves, Chinese press manu- lished and comprehensive mechanical Location: No. 99 Yangli Road, Location: No 1, Huagang Rd., Hanjiang Economic Development Yangzhou High-Tech Industry De- of experience, the company is involved in facturers very quickly began to incorpo- press manufacturer that was established Zone, Yangzhou City, Jiangsu, velopment Zone, Jiangsu, China the development, manufacturing, consult- rate the valves as a key component in in 1958. Its flagship products are a variety China ing and sales of pneumatic components Chinese presses. of mechanical presses, high-speed such as lubrication units, dual valves, and presses, powder presses, and high-performance regulators. Many of its Strong relationships with local part- iron-making machines. It is a specialist in ners pave the way for rapid growth products are used at various types of press manufacture whose goal is to pro- nese manufacturers such as Jiangsu and improvement for Chinese presses in China manufacturing sites such as large-scale vide customers with first-rate products Focus on business expansion in Yangli Group and Yangzhou Metalform- that are used in Southeast Asian coun- Southeast Asia through cooperation power plants, , automobile facto- ne of the reasons that Azbil TA and full service. with equipment Venderors ing Machine Tool is likely to increase in tries, and to support local companies ries, semiconductor fabrication plants, and has been able to make substan- Azbil TA has consistently made efforts to the future, and if so, Azbil TA’s dual valves that use the presses for production, as food factories. Otial progress in Chinese markets improve its technology in cooperation with zbil TA is advancing its business will also spread in Southeast Asian coun- “a long-term partner for customers and Meanwhile, Azbil TA is actively working for about 15 years is its strong partner- these two companies, which are second to expansion globally not only in Chi- tries as part of these presses. Azbil TA society.” on expanding its business into overseas ships with local press machine manufac- none in the Chinese mar- Ana but also in East Asian and intends to build even stronger partner- Azbil TA is expected to continue to con- markets. Especially in the field of dual turers. It has built close relationships in ket. It aims to continue to work together Southeast Asian nations. ships with Chinese machine press manu- tribute to customer’s business develop- valves, which are the central component particular with two companies, Jiangsu with local companies and to keep its pres- Especially in Southeast Asian markets facturers, including the Jiangsu Yangli ment on a global scale by providing prod- in presses, the company began entering Yangli Group Co., Ltd., and Yangzhou ence strong and stable in the machine where industrial development is promi- Group and Yangzhou Metalforming Ma- ucts and solutions produced through East Asian markets around the year 2000. Metalforming Machine Tool Co., Ltd., both press manufacturer market in China. nent, the influx of presses made by Chi- chine Tool, in areas of maintenance synergies within the azbil Group.

6 2016 Vol. 1 2016 Vol. 1 7 Validation Keywords When validation is used in connection with the manufacture of pharmaceu- ticals as a technical term, it refers to the process of establishing scientific Vol.7 evidence demonstrating that the manufacturing system, including process- AZ es and equipment, can consistently deliver the expected product quality. Scientific examination to confirm the stages of the manufacturing process meet others. soundness of procedures and rules for the predefined specifications. Without col- When drugs are manufactured, ingredi- drug manufacture and quality management lecting objective evidence that warrants ents, apparatus, equipment, operators, that safety of the finished products is as- operations, and plant environment (tem- Drugs for sickness and injuries can rough- sured, manufacturers cannot demonstrate perature, humidity, etc.) must all be re- ly be categorized into two kinds: over-the- that their drugs were properly made by corded so that the adequacy of the entire counter drugs sold in pharmacies, and proper process. manufacturing system can be ensured prescription drugs. Both kinds must be Validation consists of two major activi- and, when a problem occurs, the cause manufactured so as to always have quali- ties. The first is to verify “through scientific can be tracked. ty as intended. What if each tablet con- approaches” that procedures and the Today, pharmaceutical manufacturing tained inconsistent active ingredients (the equipment used are fit for manufacturing plants are increasingly adopting comput- chemical substances that cause the medi- drugs. ers for control of the manufacturing pro- cine’s effects)? Patients would not feel Drug manufacturers need to identify all cess, product quality, manufacturing that the medicine was safe to take. the risks with the procedures, facility, and equipment, and analysis. Such computers For that reason, many countries in the equipment (potential variables) and elimi- must be validated, and that practice is world establish GMP guideline defining the nate them to achieve consistency. called “computerized system validation” requirements that drug manufacturers must For example, for the process step to mix (CSV). meet in managing manufacturing process multiple ingredients, an ingredient may be Patients can take medicine with no fear and product quality. Such guideline requires weighed wrongly, mixing time may be too when these good practices are performed the manufacturer to document the manufac- short, or the mixer may be contaminated and by drug manufacturers. Validation activi- turing procedures and to follow them for the impurities may make their way into the prod- ties, through tireless efforts by the manu- purpose of 1) minimizing human error, 2) uct. To minimize such risks, the measurement facturers, are like an invisible warranty preventing contamination and degradation procedures, mixing specifications (including card that comes with a pharmaceutical of quality, and 3) establishing a system for time), and equipment cleaning procedures product. assuring high quality. are tested to verify their appropriateness. Acronym for good manufacturing practices. The Food and The GMP guideline prescribes an activity Temperature and humidity control is also Drug Administration (FDA) of the US government was the first to define GMP regulations. Later the World Health Organization called “validation” for assuring drug product essential because many pharmaceutical in- (WHO) developed their GMP, and many different countries started safety. Validation in this context means ex- gredients are powders that are sensitive to to adopt them. amining each stage of the process, from temperature and humidity changes. To pre- receiving raw materials to shipping the fin- vent the risk from increasing, the control of MasterControlTM offers automated Qual- ished products, in order to verify that all the air-handling equipment must be verified. ity management software systems. The control records are Replacing paper-based quality man- used as part of the evi- agement systems with MasterControlTM dence to demonstrate systems dramatically improves a com- the equipment is fit for pany’s ability to comply with FDA regu- the drug manufacturing. lations and ISO quality standards. Documentation is also essential to make ev- idence accessible to others The other major valida- tion activity is documen- tation. It is an activity to MasterControl™ is a registered trademark of MasterControl Inc. ( Salt Lake City, USA) record the data and to Azbil Corporation is a value added reseller partner of Master- ensure it is accessible to Control™. ©ad-manga.com Cover photo by Koji Mizutani, MERRY PROJECT Representative

Company/Branch office http://www.azbil.com/ Yamatake Corporation changed its name to Azbil Corporation on April 1, 2012. azbil Group PR magazine, azbil 2016 Vol. 1, No. 6 Issued by Mikako Takahashi, Public Relations Section, Corporate Planning Department, Azbil Corporation 19F Tokyo Building, 2-7-3 Marunouchi, Chiyoda-ku, Tokyo 100-6419 Japan TEL: 81-3-6810-1006 FAX: 81-3-5220-7274 URL: http://www.azbil.com/

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