AIFM2 Polyclonal Antibody

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PRODUCT DATA SHEET Bioworld Technology,Inc. AIFM2 polyclonal antibody Catalog: BS65239 Host: Rabbit Reactivity: Human BackGround: apoptosis inducing factor, mitochondria associated 2(AIFM2) Homo sapiens This gene encodes a flavopro- tein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bac- terial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010], Western Blot analysis of various cells using AMID Polyclonal Antibody Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Molecular Weight: ~ 38 kDa Swiss-Prot: Q9BRQ8 Immunohistochemical analysis of paraffin-embedded Human lung can- Purification&Purity: cer. Antibody was diluted at 1:100(4° overnight). High-pressure and The antibody was affinity-purified from rabbit antiserum temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive by affinity-chromatography using epitope-specific im- contrl (right) obtaned from antibody was pre-absorbed by immunogen munogen. peptide. Applications: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity: Western blot analysis of lysates from COS7 cells, using AIFM2 Anti- AMID Polyclonal Antibody detects endogenous levels of body. The lane on the right is blocked with the synthesized peptide. AMID protein. Note: DATA: For Bioworld Technology, Inc. Bioworld technology, co. Ltd. Add： 1660 South Highway 100, Suite 500 St. Louis Park, Add： No 9, weidi road Qixia District Nanjing, 210046, MN 55416,USA. P. R. China. Email: [email protected] Email: [email protected] Tel: 6123263284 Tel: 0086-025-68037686 Fax: 6122933841 Fax: 0086-025-68035151 .

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AIFM2 Monoclonal Antibody (M13A), Clone 2C6
AIFM2 monoclonal antibody (M13A), clone 2C6 Catalog # : H00084883-M13A 規格 : [ 200 uL ] List All Specification Application Image Product Mouse monoclonal antibody raised against a partial recombinant Western Blot (Transfected lysate) Description: AIFM2. Immunogen: AIFM2 (AAH06121, 1 a.a. ~ 339 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence: MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSFHHN VAALRASVETGFAKKTFISYSVTFKDNFRQGLVVGIDLKNQMVLLQGGE ALPFSHLILATGSTGPFPGKFNEVSSQQAAIQAYEDMVRQVQRSRFIVVV enlarge GGGSAGVEMAAEIKTEYPEKEVTLIHSQVALADKELLPSVRQEVKEILLRK Western Blot (Recombinant GVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVILCTGIKINSSA protein) YRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGL HANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVG ELISA Host: Mouse Reactivity: Human Isotype: IgG1 Kappa Quality Control Antibody Reactive Against Recombinant Protein. Testing: Western Blot detection against Immunogen (62.92 KDa) . Storage Buffer: In ascites fluid Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. Instruction: MSDS: Download Interspecies Mouse (90); Rat (90) Antigen Sequence: Datasheet: Download Applications Western Blot (Transfected lysate) Page 1 of 3 2021/6/18 Western Blot analysis of AIFM2 expression in transfected 293T cell line by AMID monoclonal antibody (M13A), clone 2C6. Lane 1: AIFM2 transfected lysate(40.5 KDa). Lane 2: Non-transfected lysate. Protocol Download Western Blot (Recombinant protein) Protocol Download ELISA Gene Information Entrez GeneID: 84883 GeneBank BC006121 Accession#: Protein AAH06121 Accession#: Gene Name: AIFM2 Gene Alias: AMID,PRG3,RP11-367H5.2 Gene apoptosis-inducing factor, mitochondrion-associated, 2 Description: Omim ID: 605159 Gene Ontology: Hyperlink Gene Summary: The protein encoded by this gene has significant homology to NADH oxidoreductases and the apoptosis-inducing factor PDCD8/AIF. Overexpression of this gene has been shown to induce apoptosis. The expression of this gene is found to be induced by tumor suppressor protein p53 in colon caner cells.
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Integrative Analysis of Genomic Amplification-Dependent Expression
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Ferroptosis: Past, Present and Future Jie Li 1,2,Fengcao3, He-Liang Yin4,5, Zi-Jian Huang1,2, Zhi-Tao Lin1,2,Ningmao1,2,Beisun1,2 and Gang Wang1,2
Li et al. Cell Death and Disease (2020) 11:88 https://doi.org/10.1038/s41419-020-2298-2 Cell Death & Disease REVIEW ARTICLE Open Access Ferroptosis: past, present and future Jie Li 1,2,FengCao3, He-liang Yin4,5, Zi-jian Huang1,2, Zhi-tao Lin1,2,NingMao1,2,BeiSun1,2 and Gang Wang1,2 Abstract Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and speciﬁc molecular mechanisms of ferroptosis still need to be further explored. This paper systematically summarizes the latest progress in ferroptosis research, with a focus on providing references for further understanding of its pathogenesis and for proposing new targets for the treatment of related diseases. Facts peroxides, or can other substances take the place of iron in ferroptosis? What is the downstream regulation mechanism of iron 1234567890():,; 1234567890():,; 1234567890():,; 1234567890():,; Ferroptosis is a new type of programmed cell death, in ferroptosis? which occurs with iron dependence.
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