Phd Thesis Final Library Copy

Total Page:16

File Type:pdf, Size:1020Kb

Phd Thesis Final Library Copy Britain and terrorism: A sociogenetic investigation ! !A thesis submitted for the degree of Doctor of Philosophy ! !By Michael James Dunning ! School of Social Sciences Brunel University January 2014 ! !2 ! ! Abstract ! This thesis is a sociogenetic investigation of terrorism that has been directed against Britain since the late eighteenth century. One of its most fundamental aims is to help lay the foundations of a figurational approach to the study of terrorism. Accordingly, I seek to answer two core and interrelated questions and apply the findings to develop an understanding of the processes and relationships that !have contributed to the emergence of home-grown ‘jihadist terrorism’ in Britain. Those questions are: i) Under what figurational conditions have the concepts of terrorism and terrorist developed, in sociogenetic terms, since they were first coined during the first French Revolution in the ! late eighteenth century? ii) Under what figurational conditions do people act according to various designations of ! terrorism? In order to develop answers to these questions several kinds of terrorism figurations related to Britain are examined. The first three chapters are dedicated to exploring the research on terrorism that has grown in recent decades. Much of it fails to develop an understanding of terrorism that has sufficient !detachment, and consequently can help, in some cases, to perpetuate terrorism figurations. Subsequent chapters move away from these mainstream approaches and show how terrorism figurations have developed in Britain from the time the concept ‘terrorism’ was first coined during the French Revolution. The core findings relate to how terrorism developed in antithesis to the concept of civilisation, and emerged as part of complex inter- and intra-state relationships and established- outsider figurations. As part of these processes, functional democratisation played a key role both in !Britain and in Britain’s relations to other countries. Finally, I show that these processes have been central to the development of the habituses and identities of the July 7 2005 London bombers. ! !3 ! ! Table of Contents Britain and terrorism: A sociogenetic investigation"..................................................1" Abstract"..................................................................................................................2" Acknowledgements".................................................................................................4" Introduction"............................................................................................................5" Section 1: Research on terrorism as part of the terrorism problem"........................31" Chapter 1: Definitions of terrorism and the essentialist trap"..................................31" Chapter 2: Research on the ‘causes’ of terrorism"..................................................44" Chapter 3: The sociogenesis of terrorism as a social scientific concern".................79" Section 2: The sociogenesis of terrorism in nineteenth century Britain as part of inter- and intra-state processes "...........................................................................86" Chapter 4: The development of the concept of terrorism in antithesis to the concept of civilisation"........................................................................................................92" Chapter 5: The sociogenesis of terrorism in nineteenth century Britain in relation to Ireland"................................................................................................................105" Chapter 6: Trades unions, reformers and terrorism".............................................122" Chapter 7: Terrorism and revolutionary Europe"...................................................133" Section 3: The sociogenesis of terrorism in the twentieth century".......................141" Chapter 8: The world wars – terrorism and inter-state violence"...........................141" Chapter 9: Terrorism, communism, the Soviet Union and the left"........................151" Chapter 10: The sociogenesis of terrorism, the end of the British Empire, the Middle East and international terrorism"..........................................................................159" Chapter 11: The fault-lines in the British monopoly of violence and domestic terrorism".............................................................................................................183" Section 4: Micro-level processes and jihadist terrorism in Britain.".......................191" Chapter 12: The case of the 7/7 bombers"...........................................................191" CONCLUSION"......................................................................................................213 ! ! ! ! ! ! !4 ! Acknowledgements ! I am indebted to a number of people for their help, feedback and support in helping me research and write about the complex and controversial subject covered in this thesis. I would not have been able to complete this work without the help and attention I received from my supervisor, Professor Jason Hughes. Jason encouraged me to develop my early ideas about the topic of terrorism and, in particular, championed my desire to approach my research from a figurational standpoint. I am also grateful to the input from my second supervisor, Professor Chris Rojek. Chris helped ensure that I remembered there is a world outside of figurational sociology. As well as my gratitude, I owe Jason !and Chris several pints and the odd curry from the many discussions we had about my thesis in Soho. There are many other people whose support has been invaluable. Foremost among those was my friend, the late Dr Amanda Rohloff. Although we often did not always agree, Amanda and I had many informative and fruitful discussions about figurational sociology and the topics we were covering for our PhDs. Selflessly, Amanda would also always help me with any practical issues related to Brunel if !I could not get to the university in person. I also received advice, support and encouragement from many others, including, in no particular order: Professor Stephen Vertigans, Dr Cas Wouters, Professor Emeritus Eric Dunning, Dr Jonathan Fletcher, Professor Stephen Mennell, Dr Norman Gabriel, Professor Joop Goudsblom, Professor Aurélie Lacassagne, Dr Paddy Dolan, Dr Stephen Loyal, Dr Irem Ozgoren, Dr Barbara Prainsack, Dr !Peter Wilkin, Professor Peter Lunt, Professor Clare Williams, Amreen Malik and Ushma Gudka. I would not have been able to complete my thesis without the support of my family and friends. My heartfelt thanks and appreciation goes to my partner, Laura, whose encouragement, sacrifice and patience has been instrumental in keeping me going. My daughter, Florence, who was born in 2011, !has inspired me to finish my thesis and have the determination to follow my ambitions. My father, Emeritus Professor Eric Dunning, also requires special mention. We have discussed sociology for almost as long as I can remember and if it was not for his inspiration I would not have embarked on my PhD in the first place. My mother, Judith, has also been fundamental in encouraging my interest in sociology, and for that I am eternally grateful. Thanks also go to my sister, Rachel, and to John Crooks for their support.# !5 ! ! Introduction ! This thesis examines how a number of macro-level processes and relationships have contributed to the development of terrorism that has been directed at Britain. It then explains how such broad structural processes, in combination with interdependent micro-level processes, have contributed to the emergence of home-grown jihadist terrorism in Britain including the July 7th, 2005 London !bombings. The macro-level processes, highlighted above, include inter- and intra-state competitive pressures, civilising and decivilising processes (including how the concept of terrorism developed in antithesis to the concept of civilisation),established-outsider relations, functional democratisation in Britain, Europe and globally, and ‘double-binds’. The interdependent micro-level processes include ‘we-I balances’, the development of certain habituses and processes of identification. It is established, in this thesis, !how these have been at the centre of British terrorism figurations since the late eighteenth century. Inter- and intra-state competitive pressures are understood as specific manifestations of more general established-outsider processes and relationships that are fundamental to all terrorism figurations. These operate on a variety of levels, from the inter-state to the related community planes and, !therefore, are a central focus of this thesis. Accordingly, I attempt to lay the foundations for a figurational sociological understanding of terrorism, as well as building on such work as has already been undertaken in this area. I, therefore, examine the sociogenetic conditions under which terrorism has come about in relation to Britain and its ‘component parts’, and utilise a number of concepts and ideas that were originally developed by Norbert Elias. This means that it is distinctively different from mainstream and other approaches to terrorism in a number of ways. For example, it moves away from concerns focused on causes of !terrorism to asking how did certain instances of terrorism come into being? Such a task, however, is complex, not least because the topic of terrorism is immense, as is borne out by the ‘mountains’ of literature dedicated to trying
Recommended publications
  • Crawford Building, 112 Whitechapel High Street, Aldgate, London, London
    Crawford Building, 112 Whitechapel High Street, Aldgate, London, London. E1 7AP 980,000 • 2 bedrooms • 2 bathrooms • Built-In Wardrobes • Large Balcony • Central Heating • Comfy Cooling • At Aldgate Tube Station • Close to all trendy amenities in The Square Mile Ref: PRA10137 Viewing Instructions: Strictly By Appointment Only General Description A luxury two bedroom, two bathroom apartment situated in The Crawford Building development, part of the Aldgate regeneration. This 977 Square Foot apartment is exquisitely decorated and features high specification throughout offering a fully fitted contemporary open plan kitchen, reception, floor to ceiling windows, fitted large 'his and hers' wardrobes in the master bedroom, a second large double bedroom, a long private balcony with access from both the reception and master bedroom and storage. The Crawford Building benefits from 24 hour concierge and is ideally built above Aldgate East tube station and is situated in the City of London, a superb location, in close proximity to a range of shops, bars and restaurants as well as to the trendy Brick Lane, Shoreditch and Tower Hill areas. Accommodation Services EPC Rating:87 Tenure We are informed that the tenure is Not Specified Council Tax Band Not Specified All measurements are approximate. The deeds have not been inspected. Please note that we have not tested the services of any of the equipment or appliances in this property. Stamp duty is not payable up to £125,000. From £125,001 to £250,000 - 2% of Purchase Price. From £250,001 to £925,000 - 5% of Purchase Price. From £925,001 to £1,500,000 - 10% of Purchase Price.
    [Show full text]
  • Shaken, Not Stunned
    Shaken, not stunned: The London Bombings of July 2005 1 Work in progress – not for circulation or citation! Project leader: Dr. Eric K Stern Case researchers: Fredrik Fors Lindy M Newlove Edward Deverell 1 This research has been made possible by the support of the Swedish National Defence College, the Swedish Emergency Management Agency and the Critical Incident Analysis Group. 1 Executive summary - The bombings of July 2005 On July 7 th , the morning rush hours in London formed the backdrop for the first suicide bombings in Western Europe in modern times. Three different parts of the London subway system were attacked around 08.50: Aldgate, Edgware Road, and Russell Square. 2 The three Tube trains were all hit within 50 seconds time. A bomb on the upper floor of a double-decker bus at Tavistock Square was detonated at 09.47. In the terrorist attacks, four suicide bombers detonated one charge each, killing 52 people. Seven people were killed by the blasts at Aldgate, six at Edgware Road, 13 at Tavistock Square, and 26 at Russel Square – in addition to the suicide bombers themselves. More than 700 people were injured. Hundreds of rescue workers were engaged in coping with the aftermath. Over 200 staff from the London Fire Brigade, 450 staff and 186 vehicles from the London Ambulance Service, several hundred police officers from the Metropolitan Police and from the City of London Police, as well as over 130 staff from the British Transport Police were involved. Patients were sent to 7 area hospitals. 3 Crucial Decision Problems 1.
    [Show full text]
  • Metric System Units of Length
    Math 0300 METRIC SYSTEM UNITS OF LENGTH Þ To convert units of length in the metric system of measurement The basic unit of length in the metric system is the meter. All units of length in the metric system are derived from the meter. The prefix “centi-“means one hundredth. 1 centimeter=1 one-hundredth of a meter kilo- = 1000 1 kilometer (km) = 1000 meters (m) hecto- = 100 1 hectometer (hm) = 100 m deca- = 10 1 decameter (dam) = 10 m 1 meter (m) = 1 m deci- = 0.1 1 decimeter (dm) = 0.1 m centi- = 0.01 1 centimeter (cm) = 0.01 m milli- = 0.001 1 millimeter (mm) = 0.001 m Conversion between units of length in the metric system involves moving the decimal point to the right or to the left. Listing the units in order from largest to smallest will indicate how many places to move the decimal point and in which direction. Example 1: To convert 4200 cm to meters, write the units in order from largest to smallest. km hm dam m dm cm mm Converting cm to m requires moving 4 2 . 0 0 2 positions to the left. Move the decimal point the same number of places and in the same direction (to the left). So 4200 cm = 42.00 m A metric measurement involving two units is customarily written in terms of one unit. Convert the smaller unit to the larger unit and then add. Example 2: To convert 8 km 32 m to kilometers First convert 32 m to kilometers. km hm dam m dm cm mm Converting m to km requires moving 0 .
    [Show full text]
  • 7 Acre 454,700 1,000
    Location The transformation of an old postal sorting office into one of London’s most vibrant LONDON 2012 OLYMPIC PARK urban quarters is almost complete. This prime location in the heart of the City, offers a haven of luxury living and unrivalled amenities set amid seven acres of landscaped ad KINGS CROSS o R k spaces still steeped in history. ar P ia WESTFIELD r to ic V 06 1 A CAMDEN STRAFFORD CITY TOWN d a o R k ar P a ri o t ic V 6 0 1 * † A Walking from Goodman’s Fields Underground from Aldgate/Aldgate East Crossrail from Liverpool Street B ** l a Aldgate East Underground Station 4 mins Whitechapel 2 mins Whitechapel 2 mins c k w a l l U Tower Gateway DLR Station 8 mins St. Pancras International 12 mins Tottenham Court Road 4 mins T p u p n e DALSTON n r e PUDDING l MORNINGTON CRESCENT S Aldgate Underground Station 9 mins Bond Street 19 mins Canary Wharf 6 mins N MILL LANE t o r e r t e K h t e r i ** n n A Tower Hill Underground Station 10 mins Green Park Bond Street 7 mins 20 mins g p p s r l o a a H c n h N d a A m e Fenchurch Street Station 13 mins Covent Garden 22 mins Paddington 10 mins 1 R 2 w p o s N a t e d o ** a r ANGEL ISLINGTON Whitechapel Crossrail Station 14 mins Stratford International 24 mins Heathrow Central 35 mins t d h A R R o 1 a 0 ST PANCRAS o CAMBRIDGE HEATH d a Liverpool Street Station 17 mins Heathrow Airport (from Paddington) 50 mins Heathrow T4 41 mins d INTERNATIONAL A 1 2 A 0 4 0 01 00 5 A A3211 d oa es Street R pper Tham ille U onv HOXTON Pent S t 8 20 1 A J IGS CROSS t o ee ad h r o St R n t G ST PANCRASt
    [Show full text]
  • Conflicting Quangos Provide Little Support for the Hospitality Industry
    March/AprilMay/June 20082008 For details of over 850 properties for sale or to let nationwide visit Page 8 Page 10 Page 19 Page 24 Register Close Advance 16 prime 18 for Investments notice town managed Fleurets’ – nine centre houses for Buyer Alert freeholds sites sale Conflicting quangos provide little support for the hospitality industry Bob Cotton Chief Executive, British Hospitality Association The government tourism, for which they are spent over responsible in their region? With £167bn on dramatic – and incomprehensible – more than 900 differences in the level of support quangos in and funding for tourism by each 2007 – up from RDA, what remains is confusion £79bn three and lack of coordination. It is years previously. claimed that RDAs spend some Even in the last £50m every year on promoting year alone, 30 new ones have been tourism, both domestically and introduced. Out of the total, £4.6bn overseas, yet this is surely what was spent by the Department of VisitEngland and VisitBritain have Culture, Media and Sport though been set up to do, as well. precious little of this was spent on tourism. Indeed, of the quangos for Why the duplication? Why is the which the DCMS is responsible, south-west competing against the VisitBritain’s grant is now being north-east, for example, to attract reduced by 20 per cent after eight domestic visitors when a co- years in which the level of funding ordinated England-wide campaign stayed the same – an effective cut, we have to deal with. There are regulatory interest in the industry, by VisitEngland would have far taking inflation into account.
    [Show full text]
  • Cutlers Court, 115 Houndsditch, London, EC3A 7BR 2,345 to 9,149 Sq Ft
    jll.co.uk/property To Let Cutlers Court, 115 Houndsditch, London, EC3A 7BR 2,345 to 9,149 sq ft • Cost effective fitted out offices • Furniture packages available • Flexible working space • Manned reception Location EPC The building is located on the north side of Houndsditch. 115 This property has been graded as E (122). Houndsditch benefits from excellent access to public transport being 3 minutes from Liverpool Street station, 4 minutes from Rent Aldgate tube station and 8 minutes from Bank Station. The £19.50 per sq ft property is situated within close proximity to Lloyd’s of London exclusive of rates, service charge and VAT (if applicable). and Broadgate and is moments from the amenities of Devonshire Square and Spitalfields. Business Rates Rates payable: £14.77 per sq ft Specification The Ground and 4th floors are available with high quality fit Service Charge outs in situ as follows: £11.85 per sq ft Ground floor EC3A 7BR - 1 x 8 person meeting room - 1 x 6 person meeting room - 1 x 4 person meeting room - Kitchen/breakout area - Cat 6 Data Cabling 4th floor - 1 x 10 person meeting room - 2 x 8 person meeting rooms - 2 on floor showers - Kitchen/breakout area - New floor outlet boxes and underfloor CAT 6 data cabling Terms New lease available from the Landlord (term certain until June Contacts 2023). Nick Lines 0207 399 5693 Viewings [email protected] Viewing via the sole agents only. Nick Going Accommodation [email protected] Floor/Unit Sq ft Rent Availability 4th 6,804 £19.50 per sq ft Available Ground 2,345 £19.50 per sq ft Available Total 9,149 JLL for themselves and for the vendors or lessors of this property whose agents they are, give notice that:- a.
    [Show full text]
  • Crawford Building, 112 Whitechapel High Street, Aldgate East, London
    Crawford Building, 112 Whitechapel High Street, Aldgate East, London. E1 7AP 490 Weekly * • Double bedroom • Modern bathroom • Built-In Wardrobe • Central Heating • Comfy Cooling • 24 Hour Concierge • At Aldgate Tube Station • Close to all trendy amenities in The Square Mile Ref: PRA10212 Viewing Instructions: Strictly By Appointment Only General Description A luxury one bedroom apartment situated in The Crawford Building development, part of the Aldgate regeneration. This apartment features high specification throughout offering a fully fitted contemporary open plan kitchen, reception, floor to ceiling windows, fitted large wardrobe and storage. The Crawford Building benefits from 24 hour concierge and is ideally built above Aldgate East tube station and is situated in the City of London, a superb location, in close proximity to a range of shops, bars and restaurants as well as to the trendy Brick Lane, Shoreditch and Tower Hill areas. Available for immediate occupation. Accommodation Services EPC Rating:84 Council Tax Band Not Specified All measurements are approximate. The deeds have not been inspected. Please note that we have not tested the services of any of the equipment or appliances in this property. Stamp duty is not payable up to £125,000. From £125,001 to £250,000 - 2% of Purchase Price. From £250,001 to £925,000 - 5% of Purchase Price. From £925,001 to £1,500,000 - 10% of Purchase Price. From £1,500,001 onwards - 12% of Purchase Price. N.B. Stamp Duty is paid by the purchaser and not the vendor. Proceeds Of Crime Act 2002: We are obliged to report any knowledge or suspicion of money laundering to NCIS (National Crime Intelligence Service) and should a report prove necessary we are precluded from conducting any further professional work without consent from NCIS.
    [Show full text]
  • Gravity and Coulomb's
    Gravity operates by the inverse square law (source Hyperphysics) A main objective in this lesson is that you understand the basic notion of “inverse square” relationships. There are a small number (perhaps less than 25) general paradigms of nature that if you make them part of your basic view of nature they will help you greatly in your understanding of how nature operates. Gravity is the weakest of the four fundamental forces, yet it is the dominant force in the universe for shaping the large-scale structure of galaxies, stars, etc. The gravitational force between two masses m1 and m2 is given by the relationship: This is often called the "universal law of gravitation" and G the universal gravitation constant. It is an example of an inverse square law force. The force is always attractive and acts along the line joining the centers of mass of the two masses. The forces on the two masses are equal in size but opposite in direction, obeying Newton's third law. You should notice that the universal gravitational constant is REALLY small so gravity is considered a very weak force. The gravity force has the same form as Coulomb's law for the forces between electric charges, i.e., it is an inverse square law force which depends upon the product of the two interacting sources. This led Einstein to start with the electromagnetic force and gravity as the first attempt to demonstrate the unification of the fundamental forces. It turns out that this was the wrong place to start, and that gravity will be the last of the forces to unify with the other three forces.
    [Show full text]
  • The International Bureau of Weights and Measures 1875-1975
    The International Bureau of Weights and Measures 1875-1975 U.S. DEPARTMENT OF COMMERCE National Bureau of Standards ""EAU of NBS SPECIAL PUBLICATION 420 Aerial view of the Pavilion de Breteuil and the immediate environs. To the east, the Seine and the Pont de Sevres; to the northwest, the Pare de Saint-Cloud: between the Pavilion de Breteuil (circled) and the bridge: the Manufacture Nationale de Porcelaine de Sevres. The new laboratories (1964) are situated north of the circle and are scarcely visible; they were built in a way to preserve the countryside. (Document Institute (leographique National, Paris). Medal commeiiKiraUn-i the centennial (if the Convention cif tlie Metre and the International Bureau of Weights and Measures. (Desifined by R. Corbin. Monnaie de Paris) The International Bureau of Weights and Measures 1875-1975 Edited by Chester H. Page National Bureau of Standards, U.S.A. and Pan I Vigoiireiix National Physieal Laboratory, U.K. Translation of tlie BIPM Centennial Volume Piibli>lieH on the ocrasioii <>( the lOOth Aniiiver^ai y ol tlie Treaty of tlie Metre May 20, 1975 U.S. DEPARTMENT OF COMMERCE NATIONAL BUREAU OF STANDARDS, Richard W. Roberts, Direcior Issued May 1 975 National Bureau of Standards Special Publication 420 Nat. Bur. Stand. (U.S.), Spec. Publ. 420. 256 pages (May 1975) CODEN: XNBSAV U.S. GOVERNMENT PRINTING OFFICE WASHINGTON: 1975 For sale by the Superintendent of Documents U.S. Government Printing Office, Washington, D.C. 20402 Paper cover Price $3.00 Stock Number 003-003-01408 Catalog Number C13.10:420 FOREWORD The metric system was made legal by Congress in 1866, the United States of America signed the Treaty of the Metre in 1875, and we have been active in international coordination of measurements since that time.
    [Show full text]
  • Metric System.Pdf
    METRIC SYSTEM THE METRIC SYSTEM The metric system is much easier. All metric units are related by factors of 10. Nearly the entire world (95%), except the United States, now uses the metric system. Metric is used exclusively in science. Because the metric system uses units related by factors of ten and the types of units (distance, area, volume, mass) are simply-related, performing calculations with the metric system is much easier. METRIC CHART Prefix Symbol Factor Number Factor Word Kilo K 1,000 Thousand Hecto H 100 Hundred Deca Dk 10 Ten Base Unit Meter, gram, liter 1 One Deci D 0.1 Tenth Centi C 0.01 Hundredth Milli M 0.001 Thousandth The metric system has three units or bases. Meter – the basic unit used to measure length Gram – the basic unit used to measure weight Liter – the basic unit used to measure liquid capacity (think 2 Liter cokes!) The United States, Liberia and Burma (countries in black) have stuck with using the Imperial System of measurement. You can think of “the metric system” as a nickname for the International System of Units, or SI. HOW TO REMEMBER THE PREFIXES Kids Kilo Have Hecto Dropped Deca Over base unit (gram, liter, meter) Dead Deci Converting Centi Metrics Milli Large Units – Kilo (1000), Hecto (100), Deca (10) Small Units – Deci (0.1), Centi (0.01), Milli (0.001) Because you are dealing with multiples of ten, you do not have to calculate anything. All you have to do is move the decimal point, but you need to understand what you are doing when you move the decimal point.
    [Show full text]
  • Rtusaeatz Nt,Rnasiivene
    THE EVENING STAR. 38488 RQQe PUBLISRIED I AILY, Except Sunday, AT THE STAR BUILDINGS, any mznslo to sen e ear.te war to Avene, Corner 11th Street, 0011T the2ing f 1a0 tothi6 clany, it is Pensaylrania by partinenty as And why aboud as me '1he Evening Star Newspaper Oompany. King at sia1 reCeve the same alten as did 4:EQRUE W. ADAMS, Pres'r. one of his subjeCm alG the representative of a Tn EvrtNan Sra i. P.red to niscribers in the royal line, who, being aocredite to the paent r ty l. ,arr rP, on ti.eir own ateount, at 10 eents amInstmration, was, at the requet of Mr. 1 er w.ak or 44 eente per wonth. Colies at the Sicmes, our consul at Bangkok, sent from Siam eT:nt; r. - cnte each. by wail-sjotaKe prel aid- on one of our naval veeea, was received by toa eente a Llouth ; ene ye,r, $6; six months, I3. the iEterPd at the Poet Office t Washington, 0., President and Mrs. Hayes at the White -ase no. ca- mail ntatter 1 Housewith effusion, entertained there by them 'Ia V.1KT ST-r-p>b ished on F.atay-*2 a and mated asa member of thefamily for a con- errst trive irni;+i. Six months, 4; 10 copies siderable lenah of time? Every attention was for j1.: 20 col, . f.r $.. ARCH lavished on this myal guest; and should not the WAll nail ";bsCriltloine meit be paid in ad- CEN handsome young King receive as much? Yet It nee; > pa r ent l.ug than o paid for.
    [Show full text]
  • Recruitment of LC3 to Damaged Golgi Apparatus
    Cell Death & Differentiation (2019) 26:1467–1484 https://doi.org/10.1038/s41418-018-0221-5 ARTICLE Recruitment of LC3 to damaged Golgi apparatus 1,2,3 4 2,3 2,3 5,6 Lígia C. Gomes-da-Silva ● Ana Joaquina Jimenez ● Allan Sauvat ● Wei Xie ● Sylvie Souquere ● 4 7 8,9 8,9 1 2,3 Séverine Divoux ● Marko Storch ● Baldur Sveinbjørnsson ● Øystein Rekdal ● Luis G. Arnaut ● Oliver Kepp ● 2,3,10,11,12,13 4 Guido Kroemer ● Franck Perez Received: 11 May 2018 / Accepted: 8 October 2018 / Published online: 22 October 2018 © ADMC Associazione Differenziamento e Morte Cellulare 2018 Abstract LC3 is a protein that can associate with autophagosomes, autolysosomes, and phagosomes. Here, we show that LC3 can also redistribute toward the damaged Golgi apparatus where it clusters with SQSTM1/p62 and lysosomes. This organelle-specific relocation, which did not involve the generation of double-membraned autophagosomes, could be observed after Golgi damage was induced by various strategies, namely (i) laser-induced localized cellular damage, (ii) local expression of peroxidase and exposure to peroxide and diaminobenzidine, (iii) treatment with the Golgi-tropic photosensitizer redaporfin and light, (iv) or exposure to the Golgi-tropic anticancer peptidomimetic LTX-401. Mechanistic exploration led to the conclusion that both reactive oxygen species-dependent and -independent Golgi damage induces a similar phenotype that 1234567890();,: 1234567890();,: depended on ATG5 yet did not depend on phosphatidylinositol-3-kinase catalytic subunit type 3 and Beclin-1. Interestingly, knockout of ATG5 sensitized cells to Golgi damage-induced cell death, suggesting that the pathway culminating in the relocation of LC3 to the damaged Golgi may have a cytoprotective function.
    [Show full text]