Appendix 1

CI- Name CI Research_Title Status Sponsor Dr Girish K Patel Consultant Dermatologist & NISCHR Research The isolation and characterisation of normal Dermatology ACTIVE Cardiff University Fellow human keratinocyte and non-melanoma skin cancer stem cells.

Dr Keir Lewis Respiratory Consultant Critical evaluation of protein and DNA biomarker Respiratory ACTIVE Hywel Dda University Health Board detection for early detection of lung cancer (WCRN SW Wales Trials portfolio - Medlung - Early detection of lung cancer: metabolic markers for high risk screening).

Dr Keir Lewis Respiratory Consultant Does smoking status after being diagnosed with Respiratory ACTIVE R&D, Withybush lung cancer influence outcome? An observational cohort study alongside a randomised trial of different smoking cessation interventions.

Dr Keir Lewis Consultant Respiratory Physician Testing Sputum Rheology, sputum fourier Respiratory ACTIVE Hywel Dda University Health Board transformed infrared spectroscopy and exhanled volatile organic compounds in diagnosing and monitoring chronic obstructive pulmonary disease.

Dr Atir Khan Consultant Physician, Diabetes & Endocrinology A comparative study of the effects of Liraglutide Diabetes CLOSED TO Hywel Dda University Health Board and Acarbose on glycaemic control, weight and RECRUITMENT Health-Related Quality Of Life (HRQOL) in Overweight type 2 Diabetic patients on Oral Hypoglycaemic Agents (OHAs) + high doses of insulin.

Dr Keir Lewis Senior Lecturer and Consultant Physician In vitro neutrophil function from the blood and Respiratory ACTIVE Mr Chris Tattersall, R&D Manager, Hywel Dda University sputum of recurrent exacerbators and stable Health Board, Withybush General Hospital, Fishguard Road, patients with moderate to severe Chronic Haverfordwest, Pembrokeshire SA61 2PZ. Tel: 01437 Obstructive Pulmonary Disease (COPD), and 773813, Email: [email protected] healthy controls.

Dr Keir Lewis Respiratory Consultant Memory Consolidation in the Obstructive Sleep Respiratory ACTIVE Hywel Dda University Health Board Apnoea Hypopnoea Syndrome.

Dr Brian Yate Consultant Anaesthetist A Pilot study to investigate the use of a standard Anaesthetics CLOSED TO Hywel Dda Local Health Board spinal anaesthetic in combination with a local RECRUITMENT anaesthetic infusion device (Braun 'On Q Pain Buster') as an alternative to thoracic epidural for analgaesia after open colorectal surgery within the framework of an ERAS protocol

Dr Keir Lewis Respiratory Consultant Sleep disordered breathing & cardiac re- Respiratory ACTIVE Hywel Dda University Health Board synchronisation therapy (Biventricular pacemaker) in patients with severe left ventricular failure.

Dr James Stroud Clinical Psychologist What works for me? A qualitative investigation Mental Health ACTIVE Hywel Dda University Health Board into clients with borderline personality disorder views of psychotherapeutic treatment.

Mr Jegadish Mathias Consultant Surgeon Randomised double blind controlled study, ACTIVE Hywel Dda University Health Board comparing the efficacy of Transversus Abdominis Plane Blocks vs Local Infiltration following Laparoscopic Colorectal Surgery in Adults.

Dr Atir Khan Consultant Physician, Diabetes & Endocrinology Safety, Tolerability and Effectiveness of Diabetes CLOSED Hywel Dda University Health Board Glucophage® SR in patients with type – 2 Diabetes and Chronic Kidney Disease (eGFR 30 to 45mL/minute/1.73m2).

Dr Granville Morris Consultant Physician Prevelence of Periodic Limb Movement in Mental Health ACTIVE Hywel Dda University Health Board Dementia with Sundowning.

Appendix 1 Research and Development Data Hywel Ddda/CI's HDUHB Page 1 of 18 Appendix 1

CI- Name CI Research_Title Status Sponsor Dr Susmita Oomman Consultant in Pain & Anaesthetics A prospective observational study for persistent Anaesthetics ACTIVE Hywel Dda University Health Board low back pain comparing usual care using TENS machine vs Interactive Neurostimulation (InterX) device.

Dr Keir Lewis Reader in Respiratory Medicine & Consultant Does flexible home telemonitoring after hospital Respiratory ACTIVE Hywel Dda University Health Board Physician discharge for COPD patients reduce hospital re- admission? A clustered, interventional trial.

Dr Sam Rice Consultant Diabetologist Does blood glucose Telemonitoring ™ and Diabetes ACTIVE Hywel Dda University Health Board remotely delivered lifestyle advice improve self management in Type 2 Diabetes (T2DM)? A prospective observational cohort study (U4H).

Dr Keir Lewis Respiratory Consultant Critical evaluation of protein and DNA biomarker Respiratory ACTIVE detection for early detection of lung cancer (WCRN SW Wales Trials portfolio - Medlung - Early detection of lung cancer: metabolic markers for high risk screening).

Dr Leir Lewis Reader in Respiratory Medicine & Consultant Comparing 3 ways of validating smoking status Respiratory ACTIVE Hywel Dda University Health Board Physician in a real life setting: exhaled carbon monoxide, slaivary cotinine and urinary cotinine.

Chris Tattersall R&D Manager & Researcher Accuracy of staff in estimating fluid volumes in ACTIVE Hywel Dda University Health Board elderly care - A pilot study.

Dr Sam Rice Consultant Diabetologist An Evaluation of a Diabetes Self-Management Diabetes ACTIVE Hywel Dda University Health Board Program developed by Standford University: A Randomised Controlled Trial.

Dr Girish K Patel Consultant Dermatologist Elucidating the transformational role of ß human Diabetes ACTIVE Hywel Dda University Health Board papillomarvirus early region genes in skin of organ transplant recipients and healthy individuals. Dr Keir Lewis Consultant Respiratory Physician Does home telemonitoring reduce healthcare Respiratory ACTIVE Hywel Dda University Health Board utilisation in patients with chronic obstructive pulmonary disease (COPD) who have had multiple hospital admissions?

Mr Ezesomaga U J Ejimogu Charge Nurse Staff Nurses' Involvement in Discharge Planning. ACTIVE University of Essex

Rachel Roberts Portfolio & Research Centre Coordinator Evaluation of Smoking Cessation Strategies in Respiratory ACTIVE Hywel Dda University Health Board Lung Cancer Patients: Developing a Tailored and Specialist Service.

Dr Keir Lewis Reader in Respiratory Medicine & Consultant A Pilot Study to examine the Effect of Acute Respiratory ACTIVE Hywel Dda University Health Board Physician Exercise on Neutrophil Function in patients with COPD.

Joy Singh Consultant Colorectal Surgeon Gastrointestinal disease - effects of surgery and ACTIVE Swansea University chemotherapy on QOL.

Delyth Lewis Telemedicine Manager Operational Research Fellowship projects: ACTIVE Proposed Demonstration Project: NHS Telemedicine - Teledermatology.

Delyth Lewis Telemedicine Manager Operational Research Fellowship projects: ACTIVE Proposed Demonstration Project: NHS Telemedicine - GP Practices.

Appendix 1 Research and Development Data Hywel Ddda/CI's HDUHB Page 2 of 18 Appendix 1

Name of PI Designation PI - Add1 Research_Title Act Area Type of Trial Status Funding Sponsor Dr Susmita Consultant in Pain Hywel Dda University Health BOTOX Prophylaxis in Chronic Migraine Version 1: Postauthorization Chronic Disease & long External Commercial CLOSED TO Allergan Inc ALLERGAN Inc. Oomman Management & Board Observational Study term conditions CTimp RECRUITMENT Anaesthetics Dr Atir Khan Consultant Physician, Hywel Dda University Health A Randomised, double-blind, placebo-controlled, parallel-group, Coronary Heart External Commercial CLOSED TO Sanofi Aventis Contact: Mr Myles Callaghan, Diabetes & Endocrinology Board multicentre study to evaluate cardiovascular outcomes during treatment Disease CTimp RECRUITMENT Clinical Research Unit, Sanofi with Lixisenatide in Type 2 diabetic patients after an Acute Coronary Aventis, One Onslow Street, Syndrome (EFC11319). (DRN345 - Commercial Portfolio adopted study) Guildford GU1 4YS.

Dr Jayne Evans Consultant Prince Philip Hospital Multicountry, cross sectionAL study to determine patient specIfic and Chronic Disease & long External Commercial CLOSED TO Abbott Laboratories Ltd Abbott Laboratories Ltd Rheumatologist General beliefs towards medicatioN and their treatment compliance to term conditions CTimp RECRUITMENT selected systemic therapies in chronic inflammatory diseases (IMID)

Dr Atir Khan Consultant Physician Hywel Dda University Health AVE0010 – EFC12626 (Lixisenatide) version 1.0: A randomized, open- Chronic Disease & long External Commercial CLOSED TO Sanofi Sanofi Board label, active-controlled, 3-arm parallel-group, 26-week study comparing term conditions CTimp RECRUITMENT the efficacy and safety of lixisenatide to that of insulin glulisine once daily and insulin glulisine three times daily in patients with Type 2 diabetes insufficiently controlled with insulin glargine with or without metformin.

Dr Nuha Haboubi Consultant in Chemical Hywel Dda University Health A Randomised, double-blind study of the efficacy and safety of REGN727 Coronary Heart External Commercial CLOSED TO Medpace Ltd Medpace Ltd Pathology Board added-on to Atovastatin versus Ezetimibe, added-on to Atorvastatin Disease Ctimp RECRUITMENT versus Atorvastatin Dose Increase, versus Switch to Rosuvastatin in Patients who are not controlled on Atorvastatin.

Dr Jon Holmes Consultant Haematologist Hywel Dda University Health Prevention of Thromboembolic Events - European Registry in Venous Other External Commercial CLOSED TO Daiichi-Sankyo Daiichi-Sankyo Board Thromboembolism CTimp RECRUITMENT

Dr Debbie Shipley Consultant Dermatologist Hywel Dda University Health Secukinumab In patients with moderate to severe active, chronic plaque Other External Commercial ACTIVE Novartis Pharmaceuticals UK Novartis Pharmaceuticals UK Ltd Board psoriasis who have failed on TNFά antaGoNists: A clinical Trial evalUating CTIMP Ltd Treatment REsults (SIGNATURE)

Dr Atir Khan Consultant Diabetologist Hywel Dda University Health A 24-Week International, Multi-centre, Randomised, Parallel-group, Chronic Disease & long External Commercial ACTIVE Bristol-Myers Squibb Bristol-Myers Squibb [CRO is Board Double-blind Trial to Evaluate Metformin Extended Release Monotherapy term conditions CTIMP International Corporation Parexel. Contact: Compared to Metformin Immediate Release Monotherapy in Adult Subjects [email protected]] with Type 2 Diabetes who have Inadequate Glycaemic Control with Diet and Exercise Dr Keir Lewis Consultant Physician Hywel Dda University Health A 52 week, double-blind, randomised, multinational, multicentre, 2-arm Chronic Disease & long External Commercial ACTIVE Chiesi Farmaceutici S.p.A Chiesi Farmaceutici S.p.A Board parallel-group, active-controlled clinical trial of fixed combination of term conditions CTIMP beclometasone dipropionate plus formoterol fumarate plus glycopyrrolate bromide administered via pMDI (CHF5993) versus fixed combination of beclometasone dipropionate plus formoterol fumarate administered via pMDI in Patients wth Chronic Obstructive Pulmonary Disease

Dr Lena Izzat Consultant Cardiovascular Hywel Dda University Health A prospective, randomised, open-label, blinded endpoint evaluation Coronary Heart External Commercial ACTIVE Daiichi Sankyo Development Daiichi Sankyo Development Ltd Physician Board (PROBE) parallel group study comparing Edoxaban (DU-176b) with Disease CTIMP Ltd Enoxaparin/Warfarin followed by Warfarin alone in subjects undergoing planned electrical cardioversion of nonvalvular atrial fibrillation

Dr Atir Khan Consultant Physician, Hywel Dda University Health A Randomised, Double-blind, Event-driven, Placebo-controlled, Multicentre Chronic Disease & long External Commercial ACTIVE Janssen-Cilag International NV Janssen-Cilag International NV - Diabetes & Endocrinology Board Study of the Effects of Canagliflozin on Renal and Cardiovascular term conditions CTIMP CRO: Quintilles Ltd Outcomes in Subjects with Type 2 Diabetes Mellitus and Diabetic Nephropathy

Mr Yeung Ng Consultant Urologist Hywel Dda University Health A Multinational, Randomised, Double-Blind, Placebo-Controlled, Phase III Cancer External Commercial ACTIVE Orion Corporation Orion Orion Corporation Orion Pharma | Board Efficacy and Safety Study of ODM-201 in Men With High-Risk Non- CTIMP Pharma UK Lead - Icon Clinical Reserach Metastatic Castration-Resitant Prostate Cancer UK Ltd

Dr Keir Lewis Senior Lecturer and Hywel Dda University Health A phase II, randomised, observer-blind, placebo-controlled, multi-centre Chronic Disease & long External Commercial ACTIVE Glaxo Smithkline Glaxo Smithkline Consultant Physician Board study to evaluate the safety, reactogenicity and immunogenicity of GSK term conditions CTIMP Biologicals’ investigational vaccine GSK2838504A, when administered intramuscularly according to a 0.2 month schedule to COPD patients aged 40 to 80 years

Dr Keir Lewis Consultant in Respiratory Hywel Dda University Health A Trial to assess the anti-inflammatory effects of Roflumilast in COPD: A Chronic Disease & long External Commercial ACTIVE Takeda Pharma Takeda Pharma Medicine Board 16-week, randomised, placebo-controlled, double blind, and parallel group term conditions CTIMP trial to assess the anti-inflammatory effects of Roflumilast in Chronic Osbstructive Pulmonary Disease.

Dr Jayne Evans Consultant Hywel Dda University Health Long-Term Experience With Abatacept In Routine Clinical Practice External Commercial CLOSED TO Rheumatologist Board Non CTIMP RECRUITMENT

Dr Keir Lewis Honorary Consultant in Hywel Dda University Health A non-interventional post authorisation study to determine the safety and Other External Commercial ACTIVE Mundipharma Research Ltd Mundipharma Research Ltd Respiratory & General Board effectiveness of Flutiform® Non CTIMP (contact: Sally Rooney, Medicine Mundipharma Research Ltd, Cambridge Science Park, Milton Road, Cambridge CB4 0AB)

Appendix 1 Research and Development Data Hywel Ddda/PI's HDUHB Page 3 of 18 Appendix 1

Name of PI Designation PI - Add1 Research_Title Act Area Type of Trial Status Funding Sponsor Dr Zahid Rafique General Practitioner Hywel Dda University Health A non-interventional post authorisation study to determine the safety and Other External Commercial NON-STARTER Mundipharma Research Ltd Mundipharma Research Ltd Board effectiveness of Flutiform® Non CTIMP (contact: Sally Rooney, Mundipharma Research Ltd, Cambridge Science Park, Milton Road, Cambridge CB4 0AB)

Mr Manoj Consultant Hywel Dda University Health INvestigation of JETREA® in Patients with Confirmed Vitreomacular Other External Commercial ACTIVE Alcon Eye Care UK Ltd Alcon Eye Care UK Ltd Kulshrestha Opthalmologist Board Traction Non CTIMP

Professor Steve Consultant Diabetologist Clinical Research Unit (CRU) Efficacy and safety of semaglutide once-weekly versus placebo in drug- Chronic Disease & long External Commercial ACTIVE Novo Nordisk Novo Nordisk - Christina Ronsholt, Bain naïve subjects with type 2 diabetes term conditions PIC International Trial Manager, Novo Nordisk A/S, Novo Alle, Denmark DK-2880. email: [email protected]

Dr Lise Estcourt Research Registrar NHSBT, Level 2 Intracranial Haemorrhage in thrombocytopenic haematology patients Cancer External MSc/PhD CLOSED TO National Health Service Blood Professor Marion Scott, National RECRUITMENT and Transplant R&D Manager, NHSBT

Dr Sam Rice Consultant Physician Hywel Dda University Health The development of a measure of barriers to exercise for individuals with Chronic Disease & long External MSc/PhD ACTIVE Ceri Jones, Deputy Director of Board type 2 diabetes term conditions Research & Innovation, Swansea University Dr Atir Khan Consultant Physician Hywel Dda University Health The development of a measure of barriers to exercise for individuals with Chronic Disease & long External MSc/PhD ACTIVE Ceri Jones, Deputy Director of Board type 2 diabetes term conditions Research & Innovation, Swansea University Mr Basharat Jameel Associate Specialist in Hywel Dda University Health COMparing treatment options for ProstAte canceR: Evaluating Patient Cancer External MSc/PhD ACTIVE Medical Research Council University College London Urology Board Preferences for the Treatment of Localised Prostate Cancer - A Discrete (MRC) Choice Experiment

Mr Simon Holt Consultant Breast Hywel Dda University Health Functional Assessment in early Breast cancer in Older Patients Cancer External MSc/PhD ACTIVE Roche Products Brighton & Sussex University Surgeon Board Hospitals NHS Trust Dr Christine Consultant Diabetologist Hywel Dda University Health REVISE - Diabesity Study: Randomisation to Endoluminal liner Chronic Disease & long External MSc/PhD ACTIVE Asssociation of British Clinical Sandwell & West Birmingham Kotonya Board (Endobarrier) alone Versus with Incretin analogue (Liraglutide) in term conditions Diabetologists Hospitals NHS Trust SustainEd Diabesity Dr Kate Parker Consultant Oncologist Hywel Dda University Health Surgical and large bore pleural procedures in malignant pleural Cancer External MSc/PhD CLOSED TO local sites receive £100 per North Bristol NHS Trust - Board Mesothelioma and Radiotherapy Trial (SMART) - A randomised controlled RECRUITMENT participant at time of [email protected] trial evaluating whether prophylactic radiotherapy reduces the incidence of randomisation & £100 per procedure tract metastases participant upon receipt of a completed data set. Dr Catherine Govan Consultant in Child and Hywel Dda University Health Developing online psychoeducation for adolescent depression Services for Children & External MSc/PhD ACTIVE Cardiff University, School of Cardiff University, lead NHS Site is Adolescent Psychiatry Board Young People Medicine Cwm Taf Health Board (see status notes) Mr William Maxwell Consultant General Hywel Dda University Health Functional Assessment in early Breast cancer in Older Patients Cancer External MSc/PhD ACTIVE Roche Products Brighton & Sussex University Surgeon with Breast Board Hospitals NHS Trust interest Mr Gokul Lingesan Consultant in Palliative Hywel Dda University Health Exploring the experiences of palliative care patients and informal carers Other External MSc/PhD ACTIVE Aberystwyth University Aberystwyth University Care Board use of home-based telehealth equipment

Miss Ann Paynter 21 Llwyncyfarthwch Llanelli An observational study to investigate the ability of Emergency Nurse Services for Children & External MSc/PhD ACTIVE Swansea University Swansea University Practitioners (ENPs) to interpret appendicular x-rays of children less than Young People five years of age following an education programme

Dr Hugh Dafforn Consultant Clinical Hywel Dda University Health The role of mindfulness and coping on burnout and occupational stress Mental Ill Heath External MSc/PhD ACTIVE Bangor University Bangor University Psychologist Board amongst health professinals employed within forensic inpatient settings

Dr Sumant Kundu Consultant Haematologist Hywel Dda University Health Diagnostic Journeys in Myeloma: Why are they so long and what may Cancer External MSc/PhD ACTIVE Tenovus Cancer Charity - PhD Bangor University Board facilitate earlier diagnosis? studentship grant

Dr Peter Cumber Consultant Haematologist Hywel Dda University Health Diagnostic Journeys in Myeloma: Why are they so long and what may Cancer External MSc/PhD ACTIVE Tenovus Cancer Charity - PhD Bangor University Board facilitate earlier diagnosis? studentship grant

Dr Rhian Fuge Consultant Haematologist Hywel Dda University Health Diagnostic Journeys in Myeloma: Why are they so long and what may Cancer External MSc/PhD ACTIVE Tenovus Cancer Charity - PhD Bangor University Board facilitate earlier diagnosis? studentship grant

Mrs Laura Andrews Pembrokeshire Hywel Dda University Health The experiecnes of Behaviour Clinical Specialists of involving services Other External MSc/PhD ACTIVE Behavioural Team Board users in the development of their PBS plans. (PBS plans are Positive Manager (Local Behaviour Support plans. PBS plans reflect the healthcare needs of the Collaborator) individual and strategies of how best to support the individual).

Simon Holt Breast Cancer Surgeon The Breast Care Unit The role of body image and body image investment in mastectomy and Cancer External MSc/PhD PROPOSED breast reconstruction

Dr Ray Majer Consultant Haemotologist Pathology Dept PT1 – A randomised trial to compare Aspirin vs Hydroxyurea/Aspirin in Cancer External Non Comm, CLOSED TO Medical Research Council Cambridge University Hospitals ‘Intermediate Risk’ Primary Thrombocythaemia and Aspirin only with CTimp RECRUITMENT (MRC) & Cancer Research UK NHS Foundation Trust & University observation in ‘Low Risk’ Primary Thrombocythaemia of Cambridge

Dr Harry Grubb Consultant Haemotologist Pathology Department PT1 – A randomised trial to compare Aspirin vs Hydroxyurea/Aspirin in External Non CLOSED TO Cancer Research UK University of Cambridge, & ‘Intermediate Risk’ Primary Thrombocythaemia and Aspirin only with Comm, CTimp RECRUITMENT Cambridge University Hospitals observation in ‘Low Risk’ Primary Thrombocythaemia NHS Foundation Trust

Appendix 1 Research and Development Data Hywel Ddda/PI's HDUHB Page 4 of 18 Appendix 1

Name of PI Designation PI - Add1 Research_Title Act Area Type of Trial Status Funding Sponsor Dr Peter Cumber Consultant Haemotologist Pathology Dept PT1 – A randomised trial to compare Aspirin vs Hydroxyurea/Aspirin in Cancer External Non Comm, CLOSED TO Medical Research Council Cambridge University Hospitals ‘Intermediate Risk’ Primary Thrombocythaemia and Aspirin only with CTimp RECRUITMENT (MRC) & Cancer Research UK NHS Foundation Trust & University observation in ‘Low Risk’ Primary Thrombocythaemia of Cambridge

Dr Mark Narain Consultant Medical Directorate ASPECT Trial - A phase IIIb, randomised, study of ASPirin and Cancer External Non CLOSED TO Esomeprazole ChemoprevenTion in Barrett's metaplasia. Comm, CTimp RECRUITMENT Dr Sajid Durrani Consultant Bronglais General Hospital ZICE – A randomized phase III, open label, multicentre, parallel group Cancer External Non CLOSED TO clinical trial to evaluate and compare the efficacy, safety profile and Comm, CTimp RECRUITMENT tolerability of oral ibandronate versus intravenous zoledronate in the treatment of breast cancer patients with bone metastases.

Dr Sian Lewis Consultant Haematologist Pathology Department MDS - Bio-molecular and Functional characterisation of bone marrow Other External Non Comm, ACTIVE Medical Research Council Sponsor: University of Oxford function in normal subjects, myelodysplastic syndromes (MDS) acute CTimp Myeloid Leukaemia (AML) and secondary disorders of haematopoiesis

Dr Peter Cumber Consultant Haemotologist Pathology Dept PET Substudy: Blinded evaluation of prognostic value of FDG-PET after 2 Cancer External Non Comm, CLOSED TO Cancer Research UK University College London cycles of chemotherapy in Diffuse Large B-cell Non-Hodgkin’s Lymphoma: CTimp RECRUITMENT a substudy to R-CHOP 21vs14 (2005.038)

Dr Thi Mau-Don Consultant Oncologist Oncology Dept Short Course Oncology Trial - A study of adjuvant chemotherapy in Cancer External Non Comm, CLOSED TO Medical Research Council University of Glasgow Phan colorectal cancer by the CaCTUS and OCT groups CTimp RECRUITMENT (MRC)

Dr Vigneswaran Consultant Clinical Oncology Dept SCOT - Short Course Oncology Trial - A study of adjuvant chemotherapy Cancer External Non Comm, CLOSED TO Vallipuram Oncologist in colorectal cancer by the CaCTUS and OCT groups CTimp RECRUITMENT

Mr Simon Holt Consultant Breast Breast Care Unit POETIC - Trial of perioperative Endocrine Therapy - individualising care to Cancer External Non Comm, CLOSED TO Cancer Research UK Institute for Cancer Research & Surgeon determine whether perioperative endocrine therapy with an aromatase CTimp RECRUITMENT Royal Marsden NHS Foundation inhibitor followed by standard adjuvant therapy improves outcome Trust compared with standard adjuvant therapy alone in post menopausal women with hormone receptor positive breast cancer (Biological arm of POETIC)

Mr William Maxwell Consultant Surgeon Medical Directorate POETIC - Trial of perioperative Endocrine Therapy - individualising care to Cancer External Non Comm, CLOSED TO Cancer Research UK Institute for Cancer Research & determine whether perioperative endocrine therapy with an aromatase CTimp RECRUITMENT Royal Marsden NHS Foundation inhibitor followed by standard adjuvant therapy improves outcome Trust compared with standard adjuvant therapy alone in post menopausal women with hormone receptor positive breast cancer (Biological arm of POETIC)

Mr Simon Holt Consultant Breast Hywel Dda University Health POETIC - Trial of perioperative Endocrine Therapy - individualising care to Cancer External Non Comm, CLOSED TO Cancer Research UK Institute for Cancer Research & Surgeon Board determine whether perioperative endocrine therapy with an aromatase CTimp RECRUITMENT Royal Marsden NHS Foundation inhibitor followed by standard adjuvant therapy improves outcome Trust compared with standard adjuvant therapy alone in post menopausal women with hormone receptor positive breast cancer (Non-biological arm of POETIC)

Dr Sajid Durrani Consultant Medical Bronglais General Hospital SCOT - Short Course Oncology Trial - A study of adjuvant chemotherapy in Cancer External Non Comm, CLOSED TO Cancer Research UK Oncologist colorectal cancer by the CaCTUS and Octo groups. CTimp RECRUITMENT

Dr Gwyneth Owen Consultant Paediatrician Child Health Department AML 17: Working parties on leukaemia in adults and children trial in acute Services for Children & External Non Comm, ACTIVE Cancer Research UK Cardiff University myeloid leukaemia or high risk myelodysplastic syndrome 17 Young People CTimp

Dr Gwyneth Owen Consultant Paediatrician Child Health Department International collaborative treatment protocol for infants under one year Services for Children & External Non Comm, ACTIVE Children's Cancer and University of Birmingham with acute lymphoblastic or biphenotypic leukaemia Young People CTimp Leukaemia Group (CCLG)

Dr Gwyneth Owen Consultant Paediatrician Child Health Department European Ewing Tumour Working Initiatives of National Groups: Ewing Services for Children & External Non Comm, ACTIVE Cancer Research UK European Organisation for Tumour Studies 1999 Young People CTimp Research and Treatment of Cancer (EORTC) Dr Gwyneth Owen Consultant Paediatrician Child Health Department High Risk Neuroblastoma (NB 2002 06): Neuroblastoma Study 1 of SIOP- Services for Children & External Non Comm, ACTIVE Cancer Research UK University Hospitals of Leicester Europe Young People CTimp NHS Trust

Dr Gwyneth Owen Consultant Paediatrician Child Health Department An International Collaborative Trial for relapsed Refractory Acute Services for Children & External Non Comm, ACTIVE Central Manchester University Central Manchester University Lymphoblastic Leukaemia (ALL) Young People CTimp Hospitals NHS Trust (CMFT) Hospitals NHS Trust (CMFT)

Dr Gwyneth Owen Consultant Paediatrician Child Health Department European Intergroup Study on Post Induction Treatment of Philadelphia Services for Children & External Non Comm, ACTIVE Leukaemia & Lymphoma Central Manchester University Positive Acute Lymphoblastic Leukaemia with Imatinib Young People CTimp Research Hospitals NHS Trust (CMFT)

Dr Gwyneth Owen Consultant Paediatrician Child Health Department STS 2006 04 RMS 2005 (ESSG1) Services for Children & External Non Comm, ACTIVE Cancer Research UK University of Birmingham Young People CTimp

Dr Sajid Durrani Consultant Medical Hywel Dda University Health STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate cancer: Cancer External Non Comm, ACTIVE Cancer Research UK Medical Research Council (MRC) Oncologist Board Evaluation of Drug Efficacy A multi-arm multi-stage randomised controlled CTimp trial (MAMS RCT)

Dr Sajid Durrani Consultant Medical Bronglais General Hospital A phase III Multicentre double blind randomised trial of Celecoxib versus Cancer External Non Comm, CLOSED TO Imperial College of Science Oncologist placebo in primary breast cancer patients. CTimp RECRUITMENT Technology and Medicine

Dr Mau-don Phan Consultant Medical Hywel Dda University Health STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate cancer: Cancer External Non Comm, ACTIVE Cancer Research UK Medical Research Council (MRC) Oncologist Board Evaluation of Drug Efficacy A multi-arm multi-stage randomised controlled CTimp trial (MAMS RCT)

Appendix 1 Research and Development Data Hywel Ddda/PI's HDUHB Page 5 of 18 Appendix 1

Name of PI Designation PI - Add1 Research_Title Act Area Type of Trial Status Funding Sponsor Dr Mau-don Phan Consultant Medical Hywel Dda University Health STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate cancer: Cancer External Non Comm, ACTIVE Cancer Research UK Medical Research Council (MRC) Oncologist Board Evaluation of Drug Efficacy A multi-arm multi-stage randomised controlled CTimp trial (MAMS RCT)

Simon Holt Breast Cancer Surgeon Breast Care Unit Effect of Perioperative AntiHER-2 therapy on Early Breast Cancer Study – Cancer External Non Comm, ON HOLD Cancer Research UK & University of Manchester & Biological phase CTimp GlaxoSmithKline Research & University Hospital of South Development Ltd Manchester Dr Keir Lewis Reader in Respiratory Hywel Dda University Health Randomised controlled trial of home mechanical ventilation in hypercapnic Chronic Disease & long External Non Comm, ACTIVE Resmed & Respironics and Guy's & St Thomas' NHS Medicine and Consultant Board chronic obstructive pulmonary disease patients post acute-hypercapnic term conditions CTimp Guy's & St Thomas' Charity Foundation Trust Physician exacerbation charitable funds.

Dr Peter Cumber Consultant Haematologist Hywel Dda University Health Tackling Early Morbidity and Mortality in Myeloma: Assessing the benefit of Cancer External Non Comm, ACTIVE NIHR Health Technology University of Birmingham Board antibiotic prophylaxis and it’s effect on health care associated infections CTimp Assessment

Dr Sumant Kundu Consultant Haematologist Hywel Dda University Health Tackling Early Morbidity and Mortality in Myeloma: Assessing the benefit of Cancer External Non Comm, ACTIVE NIHR Health Technology University of Birmingham Board antibiotic prophylaxis and it’s effect on health care associated infections CTimp Assessment

Mr Anthony Consultant ENT Surgeon Hywel Dda University Health Oral Steroids for the resolution of Otitis Media with effusion in children Services for Children & External Non Comm, ACTIVE NIHR Technology Assessment Cardiff University Howarth Board study Young People CTimp Programme & NISCHR CRC (funding for ETCs)

Dr Sajid Durrani Consultant Medical Hywel Dda University Health Alternative Chemotherapy for frail or elderly patients with advanced Cancer External Non Comm, ACTIVE Cancer Research UK University of Leeds Oncologist Board gastric or oesophageal cancer CTIMP

Dr Vallipuram Consultant Medical Hywel Dda University Health Alternative Chemotherapy for frail or elderly patients with advanced Cancer External Non Comm, ACTIVE Cancer Research UK University of Leeds Vigneswaran Oncologist Board gastric or oesophageal cancer CTIMP

Dr Phil Jones Consultant Geriatrician Hywel Dda University Health REstart or STop Antithrombotic Randomised Trial Other External Non Comm, ACTIVE British Heart Foundation University of Edinburgh Board CTIMP Dr Mau-don Phan Consultant Clinical Hywel Dda University Health A phase III trial comparing standard versus novel CRT as pre-operative Cancer External Non Comm, CLOSED Cancer Research UK University College London Oncologist Board treatment for MRI defined locally advanced rectal cancer CTIMP

Dr Mau-Don Phan Consultant Clinical Hywel Dda University Health Orteronel maintenance therapy in patients with metastatic castration Cancer External Non Comm, ON HOLD SAKK - Swiss Group for Cancer University of Southampton Oncologist Board resistant prostate cancer and non-progressive disease after first-line CTIMP Research docetaxel therapy: A multicentre randomised double-blind placebo- controlled phase III trial

Dr Mau-don Phan Consultant Oncologist Oncology Dept Molecular selection of therapy in colorectal cancer: a molecularly stratified Cancer External Non Comm, ACTIVE Cancer Research UK & NIHR Medical Research Council (MRC) randomised controlled trials programme CTIMP Efficacy and Mechanism Evaluation Dr Mau-Don Phan Consultant Clinical Hywel Dda University Health A Prospective Randomised Phase III Study of Observation versus Cancer External Non Comm, ACTIVE Cancer Research UK Institute of Cancer Research ECMC Oncologist Board Screening MRI and Pre-Emptive Treatment in Castrate Resistant Prostate CTIMP Cancer Patients with Spinal Metastasis

Mr Simon Holt Consultant Surgeon Hywel Dda University Health Mammographic surveillance in breast cancer patients aged 50 years and Cancer External Non Comm, ACTIVE NIHR Technology Assessment University of Warwick, Co- Oncologist Board over: a randomised controlled trial CTIMP programme sponsored by University Hospitals Coventry & Warwickshire

Mr Simon Holt Consultant Surgeon Hywel Dda University Health Mammographic surveillance in breast cancer patients aged 50 years and Cancer External Non Comm, ACTIVE NIHR Technology Assessment University of Warwick, Co- Oncologist Board over: a randomised controlled trial CTIMP programme sponsored by University Hospitals Coventry & Warwickshire

Mr Robert Maxwell Consultant Surgeon Hywel Dda University Health Mammographic surveillance in breast cancer patients aged 50 years and Cancer External Non Comm, ACTIVE NIHR Technology Assessment University of Warwick, Co- Oncologist Board over: a randomised controlled trial CTIMP programme sponsored by University Hospitals Coventry & Warwickshire

Dr Phil Jones Consultant Geriatrician Hywel Dda University Health A Multicentre randomised trial to establish the effect (s) of routine Chronic Disease & long External Non Comm, ACTIVE Stroke Association & NIHR University of Edinburgh Board administration of Fluoxetine for six months in patients with a recent stroke term conditions CTIMP

Dr Jeremy Williams Consultant in Emergency Accident & Emergency Unit Prehospital Assessment of the Role of Adrenaline: Measuring the Other External Non Comm, ACTIVE NIHR Health Technology University of Warwick Medicine Effectiveness of Drug administration In Cardiac arrest CTIMP Assessment

Dr Peter Cumber Consultant Haematologist Hywel Dda University Health Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab Cancer External Non Comm, ACTIVE Cancer Research UK & Janssen University of Leeds Board CTIMP Pharmeceutica NV Dr Amanda Coulson Consultant Department of Integrated Prospective observations study of the secondary care management of Other External Non Comm, ACTIVE British Society for University of Manchester Rheumatologist Medicine patients with early rheumatoid arthritis in the UK. [Toxicity from biologic Non Drug Rheumatology (BSR) therapy (BSRBR) - Prospective observational study of the long term hazards of biologic therapy in rheumatoid arthritis]

Dr Sajid Durrani Consultant Medical Bronglais General Hospital MALCS - National Case Control study of Mesothelioma and Lung Cancer in Cancer External Non Comm, ACTIVE Health & Safety Executive Institute of Cancer Research, CR- Oncologist relation to occupation Non Drug uk

Dr Mau-don Phan Consultant Oncologist Oncology Dept National Study of Colorectal Cancer Genetics Cancer External Non Comm, ACTIVE Cancer Research UK & Core - The Institute for Cancer Research Non Drug The Digestive Disorders Foundation

Carol Thomas Lead Research Nurse Ward 10 National study of colorectal cancer genetics Cancer External Non Comm, ACTIVE Cancer Research UK & Core - The Institute for Cancer Research Non Drug The Digestive Disorders Foundation

Appendix 1 Research and Development Data Hywel Ddda/PI's HDUHB Page 6 of 18 Appendix 1

Name of PI Designation PI - Add1 Research_Title Act Area Type of Trial Status Funding Sponsor Dr Emma Veysey Consultant Dermatologist WWGH A study to investigate the genetics of In situ Carcinoma of the ductaL Cancer External Non Comm, ACTIVE NIHR Research for Patient University of London subtype Non Drug Benefit (RfPB)

Sarah Jones Research Nurse Hywel Dda University Health A study to investigate the genetics of In situ Carcinoma of the ductaL Cancer External Non Comm, ACTIVE NIHR Research for Patient University of London Board subtype. Non Drug Benefit (RfPB)

Dr Z Sibanda Consultant General Medical Dept International Collaborative Infantile Spasms Study: A randomised trial in Services for Children & External Non Comm, ACTIVE Castang Foundation Royal United Hospital Bath NHS the medicinal treatment of infantile spasms Young People Non Drug Trust

Dr Girish Patel Consultant Dermatologist Hywel Dda University Health British Association of Dermatologists Biological Interventions Register Other External Non Comm, ACTIVE Wyeth - Nina Kola - 01628 University of Manchester Board Non Drug 414979, email ; [email protected] Mr Basharat Jameel Staff Surgeon OG Ward UK Genetic Prostate Cancer Study Cancer External Non Comm, ACTIVE Cancer Research UK ICR & Royal Marsden NHS Non Drug Foundation Trust & Institute for Cancer Research Dr Ian Rees Consultant Physician Department of Integrated Investigation of the genetic and molecular pathogenesis of Primary Biliary Other External Non Comm, ACTIVE Sponsor- Cambridge University Medicine Cirrhosis Non Drug Hospital NHS Foundation Trust, R&D Office, Box 146, Addenbrookes Hospital, Hills Road, Cambridge, CB2 0QQ

Dr Imroz Salam Consultant Physician Department of Integrated Investigation of the genetic and molecular pathogenesis of Primary Biliary Other External Non Comm, ACTIVE Sponsor- Cambridge University Medicine Cirrhosis Non Drug Hospital NHS Foundation Trust, R&D Office, Box 146, Addenbrookes Hospital, Hills Road, Cambridge, CB2 0QQ

Dr Mark Narain Consultant General Department of Integrated A Collaborative Study to Determine the Genetic Basis of Primary Other External Non Comm, ACTIVE Physician and Medicine Sclerosing Cholangitis Non Drug Gastroenterologist Dr Faiz Ali Consultant Department of Integrated A Collaborative Study to Determine the Genetic Basis of Primary Other External Non Comm, ACTIVE Medicine Sclerosing Cholangitis Non Drug

Dr Ian Rees Consultant Department of Integrated A Collaborative Study to Determine the Genetic Basis of Primary Other External Non Comm, ACTIVE Gastroenterologist Medicine Sclerosing Cholangitis Non Drug

Dr Imroz Salam Consultant Department of Integrated A Collaborative Study to Determine the Genetic Basis of Primary Other External Non Comm, ACTIVE Gastroenterologist Medicine Sclerosing Cholangitis Non Drug

Carol Thomas Lead Research Nurse Ward 10, Clinical Trials Office UK Genetic Prostate Cancer Study Cancer External Non Comm, ACTIVE Cancer Research UK ICR & Royal Marsden NHS Non Drug Foundation Trust & Institute for Cancer Research Mr Simon Holt Consultant Breast Surgical Department Carcinoma of uncertain primary - CUP - Potential for real time PCR in Cancer External Non Comm, ACTIVE Princess Alexandra Hospital NHS Surgeon determining the primary sites of metastatic carcinoma Non Drug Trust

Dr Matthew Consultant Psychiatrist & MHLD Genetic susceptibility to cognitive deficits across the schizophrenia / Mental Ill Heath External Non Comm, ACTIVE Medical Research Council - Cardiff University Research & Sargeant AMD bipolar disorder diagnostic divide Non Drug Commercial Division. 02920 879131. Matthew Harris, Research Governance Officer. [email protected]

Dr Mark Narain Consultant General Department of Integrated Investigation of the genetic and molecular pathogenesis of Primary Biliary Other External Non Comm, ACTIVE Sponsor- Cambridge University Physician and Medicine Cirrhosis Non Drug Hospital NHS Foundation Trust, Gastroenterologist R&D Office, Box 146, Addenbrookes Hospital, Hills Road, Cambridge, CB2 0QQ

Dr Faiz Ali Consultant Physician Dept of Integrated Medicine Investigation of the genetic and molecular pathogenesis of Primary Biliary Other External Non Comm, ACTIVE Sponsor- Cambridge University Cirrhosis Non Drug Hospital NHS Foundation Trust, R&D Office, Box 146, Addenbrookes Hospital, Hills Road, Cambridge, CB2 0QQ

Dr Simon Mahon Medical Director Hywel Dda University Health Measuring Harm and Informing Quality Improvement Longitudinally in the Other External Non Comm, ACTIVE NIHR Service Delivery Cardiff University Board Welsh NHS Non Drug Organisation

Dr Phil Jones Consultant Geriatrician Ystwyth Ward Molecular Genetic Studies of Neurodegenerative Disorders Services for Older External Non Comm, ACTIVE Medical Research Council University of Birmingham People Non Drug (MRC) Dr Chris James Consultant Physician Hywel Dda University Health Molecular Genetic Studies of Neurodegenerative Disorders Services for Older External Non Comm, ACTIVE Medical Research Council University of Birmingham Board People Non Drug (MRC) Dr Sam Rice Consultant in Diabetes & Hywel Dda University Health Immune Cell Studies in Type 1 Diabetes Chronic Disease & long External Non Comm, ACTIVE Funding secured from Cardiff University Endocrinology Board term conditions Non Drug European Union programme grant Dr Atir Khan Consultant in Diabetes & Hywel Dda University Health Immune Cell Studies in Type 1 Diabetes Chronic Disease & long External Non Comm, ACTIVE Funding secured from Cardiff University Endocrinology Board term conditions Non Drug European Union programme grant Dr Paul Underwood Consultant in Diabetes & Hywel Dda University Health Immune Cell Studies in Type 1 Diabetes Chronic Disease & long External Non Comm, ACTIVE Funding secured from Cardiff University Endocrinology Board term conditions Non Drug European Union programme grant Dr Christine Consultant in Diabetes & Hywel Dda University Health Immune Cell Studies in Type 1 Diabetes Chronic Disease & long External Non Comm, ACTIVE Funding secured from Cardiff University Kotonya Endocrinology Board term conditions Non Drug European Union programme grant Appendix 1 Research and Development Data Hywel Ddda/PI's HDUHB Page 7 of 18 Appendix 1

Name of PI Designation PI - Add1 Research_Title Act Area Type of Trial Status Funding Sponsor Dr Russell Canavan Consultant Hywel Dda University Health ELF to Uncover Cirrhosis as an Indication for Diagnosis and Action for Chronic Disease & long External Non Comm, CLOSED TO NIHR Funded. Leeds Teaching Hospital Gastroenterologist Board Treatable Events - Investigation of the effectiveness and cost term conditions Non Drug RECRUITMENT effectiveness of the Enhanced Liver Fibrosis Test in detecting cirrhosis to facilitate early management of portal hypertension and detection of hepatocellular cancer

Graham O'Connor AMD Mental Health Hywel Dda University Health A case control study of Sudden Death in psychiatric in-patients and the Mental Ill Heath External Non Comm, ACTIVE National Patient Safety Agency University of Manchester Board relationship with psychotropic drugs Non Drug

Dr Ray Majer Consultant in Palliative Hywel Dda University Health Caring for young adults with complex disabilities in adult specialist Other External Non Comm, CLOSED TO Cardiff University Cardiff University Medicine & Local Board palliative care services: a national survey of the views of nursing staff Non Drug RECRUITMENT Collaborator Dr Anne Barnes Associate Specialist & Hywel Dda University Health Caring for young adults with complex disabilities in adult specialist Other External Non Comm, ACTIVE Cardiff University Cardiff University Local Collaborator Board palliative care services: a national survey of the views of nursing staff Non Drug

Graham O'Connor AMD Mental Health Hywel Dda University Health The National Confidential Inquiry into Suicide and Homicide by People with Mental Ill Heath External Non Comm, ACTIVE National Patient Safety Agency University of Manchester Board Mental Illness. Non Drug Dr Debbie Shipley Consultant Dermatologist Hywel Dda University Health Bio-markers of Systemic Treatment Outcomes in Psoriasis Other External Non Comm, ACTIVE The Psoriasis Association Guy's & St Thomas' NHS Board Non Drug Foundation Trust Mrs Rachel Griffiths EoLC Co-ordinator Hywel Dda University Health Performance Feedback in EoLC: V.2 Services for Older External Non Comm, ACTIVE Betsi Cadwalader University Bangor University Board People Non Drug Health Board Dr Christine Consultant in Diabetes & Hywel Dda University Health An Incident and high risk type 1 diabetes research cohort - After Diagnosis Chronic Disease & long External Non Comm, ACTIVE Diabetes UK & Juvenile Imperial College, London Kotonya Endocrinology Board Diabetes REsearch Support System-2 term conditions Non Drug Diabetes Research Foundation Limited (JDRF) Dr Sam Rice Consultant in Diabetes & Hywel Dda University Health An Incident and high risk type 1 diabetes research cohort - After Diagnosis Chronic Disease & long External Non Comm, ACTIVE Diabetes UK & Juvenile Imperial College, London Endocrinology Board Diabetes REsearch Support System-2 term conditions Non Drug Diabetes Research Foundation Limited (JDRF) Dr Paul Underwood Consultant in Diabetes & Hywel Dda University Health An Incident and high risk type 1 diabetes research cohort - After Diagnosis Chronic Disease & long External Non Comm, ACTIVE Diabetes UK & Juvenile Imperial College, London Endocrinology Board Diabetes REsearch Support System-2 term conditions Non Drug Diabetes Research Foundation Limited (JDRF) Dr Atir Khan Consultant in Diabetes & Hywel Dda University Health An Incident and high risk type 1 diabetes research cohort - After Diagnosis Chronic Disease & long External Non Comm, ACTIVE Diabetes UK & Juvenile Imperial College, London Endocrinology Board Diabetes REsearch Support System-2 term conditions Non Drug Diabetes Research Foundation Limited (JDRF) Dr Mau-don Phan Consultant Oncologist Oncology Dept UK Genetic Prostate Cancer Study Cancer External Non Comm, ACTIVE Cancer Research UK ICR & Royal Marsden NHS Non Drug Foundation Trust & Institute for Cancer Research Dr Atir Khan Consultant Physician Diabetes & Endocrinology Self-monitoring of blood glucose (SMBG): comparison of no SMBG, SMBG Chronic Disease & long External Non Comm, CLOSED TO European Foundation for the Swansea University alone and SMBG with telecare term conditions Non Drug RECRUITMENT study of Diabetes & Roche Diagnostics GmbH Dr Sam Rice Consultant Physician Diabetes & Endocrinology Self-monitoring of blood glucose (SMBG): comparison of no SMBG, SMBG Chronic Disease & long External Non Comm, CLOSED TO European Foundation for the Swansea University alone and SMBG with telecare term conditions Non Drug RECRUITMENT study of Diabetes & Roche Diagnostics GmbH Dr Apparao Biradar Consultant in Old Age Hywel Dda University Health An observational post-authorisation safety specialist cohort event Chronic Disease & long External Non Comm, ACTIVE Merck funded Drug Safety Research Unit Psychiatry Board monitoring (SCEM) study to monitor the safety and utilisation of asenapine term conditions Non Drug (Sycrest) in the mental health care setting.

Dr Paul Underwood Consultant Physician Diabetes & Endocrinology Self-monitoring of blood glucose (SMBG): comparison of no SMBG, SMBG Chronic Disease & long External Non Comm, CLOSED TO European Foundation for the Swansea University alone and SMBG with telecare term conditions Non Drug RECRUITMENT study of Diabetes & Roche Diagnostics GmbH Dr Nuha Haboubi Consultant Chemical Hywel Dda University Health Variants of Uncertain Significance in Familial Hypercholesterolaemia (FH) Services for Children & External Non Comm, ACTIVE Cardiff University, School of Cardiff University Pathologist Board Young People Non Drug Medicine (funding Kate Haralambos as UK wide study manager), and Wales FH Service funding extra test costs

Mr Simon Holt Consultant Surgical Hywel Dda University Health Prevention of Lymphoedema after axillary clearance by external Cancer External Non Comm, ACTIVE NIHR Programme Grants for University Hospital of South Oncologist Board compression Non Drug Applied Research Manchester

Dr Gareth Collier Consultant Respiratory Hywel Dda University Health Roy Castle Lung Cancer Cohort Feasibility Study Cancer External Non Comm, ACTIVE The Roy Castle Lung Cancer University of Southampton Physician Board Non Drug Foundation Dr Mark Narain Consultant Gneral Hywel Dda University Health Chemoprevention Of Premalignant Intestinal Neoplasia (ChOPIN) Cancer External Non Comm, ACTIVE Physician & Board incorporating Genetic Epidemiology Study of Oesophageal Cancer Non Drug Gastroenterologist Dr Sumant Kundu Consultant Haematologist Hywel Dda University Health An Observational Postauthorization Safety Specialist Cohort Event Other External Non Comm, ACTIVE Bayer Pharma AC DSRU Board Monitoring Study (SCEM) to Monitor the Safety and Utilization of Non Drug Rivaroxaban (Xarelto®) for the Prevention of Stroke in Patients with AF, Treatment of DVT and PE, and the Prevention of Recurrent DVT and PE in the Secondary Care Hospital Setting in England

Suzanne Tarrant Consultant Clinical Hywel Dda University Health Assessing NHS Staff Wellbeing before, during and after Christmas Other External Non Comm, ACTIVE City University London City University London Psychologist Board Non Drug Dr Brian Campbell Consultant Anaesthetist Hywel Dda University Health A Sprint National Anaesthesia Project (SNAP) to survey patient reported Other External Non Comm, ACTIVE National Institute for Academic University College London Board outcome after anaesthesia in UK Hospitals Non Drug Anaesthesia & UCL/UCLH NIHR Hospitals NHS Foundation Trust Biomedical Research Centre

Dr Stuart Gill Consultant Anaesthetist Hywel Dda University Health A Sprint National Anaesthesia Project (SNAP) to survey patient reported Other External Non Comm, ACTIVE National Institute for Academic University College London Board outcome after anaesthesia in UK Hospitals Non Drug Anaesthesia & UCL/UCLH NIHR Hospitals NHS Foundation Trust Biomedical Research Centre

Appendix 1 Research and Development Data Hywel Ddda/PI's HDUHB Page 8 of 18 Appendix 1

Name of PI Designation PI - Add1 Research_Title Act Area Type of Trial Status Funding Sponsor Dr Sunita Agarwal Consultant Anaesthetist Hywel Dda University Health A Sprint National Anaesthesia Project (SNAP) to survey patient reported Other External Non Comm, ACTIVE National Institute for Academic University College London Board outcome after anaesthesia in UK Hospitals Non Drug Anaesthesia & UCL/UCLH NIHR Hospitals NHS Foundation Trust Biomedical Research Centre

Dr Stuart Gill Consultant Anaesthetist Hywel Dda University Health A Sprint National Anaesthesia Project (SNAP) to survey patient reported Other External Non Comm, ACTIVE National Institute for Academic University College London Board outcome after anaesthesia in UK Hospitals Non Drug Anaesthesia & UCL/UCLH NIHR Hospitals NHS Foundation Trust Biomedical Research Centre

Dr Lena Izzat Consultant Cardiovascular Hywel Dda University Health An Observational Postauthorization Safety Specialist Cohort Event Other External Non Comm, ACTIVE Bayer Pharma AC DSRU Physician Board Monitoring Study (SCEM) to Monitor the Safety and Utilization of Non Drug Rivaroxaban (Xarelto®) for the Prevention of Stroke in Patients with AF, Treatment of DVT and PE, and the Prevention of Recurrent DVT and PE in the Secondary Care Hospital Setting in England

Dr Maria Hobrok Consultant Anaesthetist Hywel Dda University Health International Surgical Outcomes Study Other External Non Comm, ACTIVE Nestle Health Science SA Queen Mary, University of London Board Non Drug Professor Julian Consultant in Medical Hywel Dda University Health Experiences of People with Copy Number Variants Other External Non Comm, ACTIVE National Institute of Health, Cardiff University Sampson Genetics Board Non Drug Bethesda, Maryland USA

Dr Girish K Patel Consultant Dermatologist Hywel Dda University Health The isolation and characterisation of normal human keratinocyte and non- Cancer External Non Comm, ACTIVE British Skin Foundation Cardiff University & NISCHR Research Board melanoma skin cancer stem cells Non Drug Fellow

Dr Sumant Kundu Consultant Haematologist Hywel Dda University Health Oral Coagulation agent associated bleeding events reporting system Other External Non Comm, ACTIVE British Society for Haematology Barts Health NHS Trust Board Non Drug Dr Michael Martin Consultant Anaesthetist Hywel Dda University Health Enhanced Peri-Operative Care for High-risk patients: A stepped wedge Other External Non Comm, ACTIVE NIHR Health Services and Queen Mary, University of London Board randomised cluster trial of a quality improvement intervention for patients Non Drug Delivery Research undergoing emergency laparotomy

Dr Graham Consultant Psychiatrist Hywel Dda University Health Improving the experience of dementia and enhancing active life Services for Older External Non Comm, ACTIVE Bangor University Bangor University O'Connor Board People Non Drug Mr Simon Holt Consultant Surgical Breast Care Unit A Phase III Trial of Surgery versus Active Monitoring for Low Risk Ductal Cancer External Non Comm, ACTIVE NIHR Health Technology University of Birmingham Oncologist Carcinoma in Situ (DCIS) Non Drug Assessment Programme

Gareth Collier Consultant Hywel Dda University Health Development of an Intervention to support lung cancer patients and their Cancer External Non Comm, ACTIVE Velindre Charitable Funds, The Cardiff University Board clinicians when considering sytemic Anti-Cancer Therapy Non Drug Velindre Stepping Stones Appeal Ms Vanessa Davies Head of Occupational Hywel Dda University Health A cluster randomised controlled trial of a behavioural change package to Other External Non Comm, ACTIVE NIHR - HTA commissioned Guy's & St Thomas' NHS Health Board prevent hand dermatitis in nurses working in the National Health Service Non Drug research grant Foundation Trust

Professor Julian Consultant in Medical Hywel Dda University Health Experiences of CHildren with COpy number variants Other External Non Comm, ACTIVE National Institute of Health, Cardiff University Sampson Genetics Board Non Drug Bethesda, Maryland USA

Dr Graham Consultant Psychiatrist Hywel Dda University Health Assessing Mental Health Recovery V1-031213 Mental Ill Heath External Non Comm, ACTIVE NISCHR Social Care Fund Swansea University O'Connor Board Non Drug Mr Richard Jones Advanced Nurse Hywel Dda University Health Social Work Intervention following Self Harm: Feasibility of replication of a Mental Ill Heath External Non Comm, ACTIVE Swansea University Swansea University Practitioner Mental Health Board successful intervention for people Non Drug admitted to hospital

Dr Faiz Ali Consultant Hywel Dda University Health A feasibility randomised controlled trial (RCT) of contrast enhanced vs Cancer External Non Comm, ACTIVE NISCHR RfPPB Cardiff University Gastroenterologist Board nonenhanced colonoscopy in index bowel cancer screening to reduce Non Drug bowel cancer mortality

Ms Claire Hurlin Head of Chronic Hywel Dda University Health Qualitative EvAluation of the Chronic Obstructive Pulmonary Disease SElf- Chronic Disease & long External Non Comm, ACTIVE Swansea University Swansea University Conditions Management Board Management for Life Programme (EASE) term conditions Non Drug

Dr Andrea Consultant Clinical Hywel Dda University Health Towards the Development of an Interpersonal Model of OCD: Assessment Mental Ill Heath External Non Comm, ACTIVE University of Bath University of Bath Mowthorpe Psychologist Board of the role of attachment style in the development of reassurance seeking Non Drug behaviours in adolescents with OCD

Mr Julian Jeremy Consulting Counselling Hywel Dda University Health Towards the Development of an Interpersonal Model of OCD: Assessment Mental Ill Heath External Non Comm, ACTIVE University of Bath University of Bath Psychologist Board of the role of attachment style in the development of reassurance seeking Non Drug behaviours in adolescents with OCD

Dr Euan Hails Senior Lecturer & Clinical Hywel Dda University Health Auditory-verbal hallucinations in Welsh-English bilingual patients with Mental Ill Heath External Non Comm, ACTIVE Wellcome Trust, Strategic University of Liverpool Lead Psychosis & Board psychosis Non Drug Awards in Medical Humanities Recovery HDUHB & SU

Dr Igor Otahal Consultant in Intensive Hywel Dda University Health Size of Sepsis in Wales: Point prevalence study of sepsis in the acute Other External Non Comm, ACTIVE None Cwm Taf University Health Board Care and Anaesthetics Board hospital Non Drug

Dr Saran Nicholas Consultant Haematologist Hywel Dda University Health Oral Coagulation agent associated bleeding events reporting system Other External Non Comm, ACTIVE British Society for Haematology Barts Health NHS Trust Board Non Drug Mrs Kelly Rice Occupational Therapist Hywel Dda University Health Occupational Therapy. Right way, right place Other External Non Comm, ACTIVE No funding Cwm Taf UHB Board Non Drug Meddygfa Tywyn Bach Assessment of the safety of Long Acting Beta Agonists (LABAs) in Asthma Chronic Disease & long External Non Comm, PROPOSED European Commission - FP7- Universite Claude Bernard Lyon 1 in Routine Care by combining healthcare databases and direct patient term conditions Non Drug HEALTH-2011-single-stage GA (UK Legal Representative - follow up nº282593 University of Nottingham

Appendix 1 Research and Development Data Hywel Ddda/PI's HDUHB Page 9 of 18 Appendix 1

Name of PI Designation PI - Add1 Research_Title Act Area Type of Trial Status Funding Sponsor Meddygfa Wdig Assessment of the safety of Long Acting Beta Agonists (LABAs) in Asthma Chronic Disease & long External Non Comm, PROPOSED European Commission - FP7- Universite Claude Bernard Lyon 1 in Routine Care by combining healthcare databases and direct patient term conditions Non Drug HEALTH-2011-single-stage GA (UK Legal Representative - follow up nº282593 University of Nottingham

Mr Baba Gana Consultant Urologist Hywel Dda University Health Adjustable Anchored Single-Incision Mini-Slings Versus Standard Tension- Other External Non Comm, PROPOSED University of Aberdeen University of Aberdeen Board Free Mid-Urethral Slings in the Surgical Management Of Female Stress Non Drug Urinary Incontinence; A Pragmatic Multicentre Non–Inferiority Randomised Controlled Trial.

Dr Sian Lewis Consultant Haematologist Hywel Dda University Health Clinical Validation of biomarkers determining resistance to BTK inhibition Cancer External Non Comm, ACTIVE Biomedical Research Centre, The Royal Marsden Hospital NHS Board with Ibrutinib in Mantle Cell Lymphoma and Chronic Lymphocytic Non Drug Royal Marsden Hospital NHS Trust Leukaemia - Stage 1 Trust

Miss Joy Singh Consultant Colorectal Hywel Dda University Health Hughes Abdominal Repair Trial: Abdominal wall closure techniques to Other External Non Comm, PROPOSED No external funding Cardiff & Vale University Health Surgeon Board reduce incidence of incisional hernias: multicentre pragmatic randomised Non Drug Board trial

Mr Baba Gana Consultant Urologist Hywel Dda University Health Adjustable Anchored Single-Incision Mini-Slings Versus Standard Tension- Other External Non Comm, PROPOSED University of Aberdeen University of Aberdeen Board Free Mid-Urethral Slings in the Surgical Management Of Female Stress Non Drug Urinary Incontinence; A Pragmatic Multicentre Non–Inferiority Randomised Controlled Trial.

Dr Peter Cumber Consultant Haematologist Hywel Dda University Health An Observational Postauthorization Safety Specialist Cohort Event Other External Non Comm, PROPOSED Bayer Pharma AC DSRU Board Monitoring Study (SCEM) to Monitor the Safety and Utilization of Non Drug Rivaroxaban (Xarelto®) for the Prevention of Stroke in Patients with AF, Treatment of DVT and PE, and the Prevention of Recurrent DVT and PE in the Secondary Care Hospital Setting in England

Dr Sian Lewis Consultant Haematologist Hywel Dda University Health Clinical Validation of biomarkers determining resistance to BTK inhibition Cancer External Non Comm, ACTIVE Biomedical Research Centre, The Royal Marsden Hospital NHS Board with Ibrutinib in Mantle Cell Lymphoma and Chronic Lymphocytic Non Drug Royal Marsden Hospital NHS Trust Leukaemia - Stage 1 Trust

Dr Maria Hobrok Consultant Anaesthetist Hywel Dda University Health PrEvalence of Acute and Chronic Kidney Disease treated by renal Chronic Disease & long External Non Comm, PROPOSED European Society of Intensive Royal Surrey County Hospital NHS Board replacement therapy in the ICU Environment (PEACE). A prospective term conditions Non Drug Care Medicine Foundation Trust international, multi-centre, prevalence study on the epidemiology of the use of renal replacement therapy for ICU patients who have acute kidney injury and chronic end stage kidney disease.

Dr Hatashe Associate Specialist in Hywel Dda University Health The EMBARC European Bronchiectasis Registry Other External Non Comm, ACTIVE European Multicentre Dundee University? Respiratory Medicine Board Non Drug Bronchiectasis Audit and Research Collaboration Dr Daniel Warm Service Transformation Hywel Dda University Health Patient and professional acceptability of telehealth to monitor COPD and Other External Non Comm, PROPOSED Dr Daniel Warm has funding Aberystwyth University Programme Manager Board Diabetes Non Drug secured

Dr Keir Lewis Respiratory Consultant Respiratory Centre Critical evaluation of protein and DNA biomarker detection for early Cancer Inhouse ACTIVE Hywel Dda University Health Board detection of lung cancer (WCRN SW Wales Trials portfolio - Medlung - Early detection of lung cancer: metabolic markers for high risk screening)

Dr Kate Hatashe Associate Specialist General Medical Dept Critical evaluation of protein and DNA biomarker detection for early Cancer Inhouse ACTIVE detection of lung cancer (WCRN SW Wales Trials portfolio - Medlung - Early detection of lung cancer: metabolic markers for high risk screening)

Rachel Roberts Research Assistant Respiratory Centre Does smoking status after being diagnosed with lung cancer influence Cancer Inhouse ACTIVE R&D, Withybush outcome? An observational cohort study alongside a randomised trial of different smoking cessation interventions

Dr Keir Lewis Consultant Respiratory Respiratory Centre Testing Sputum Rheology, sputum fourier transformed infrared Chronic Disease & long Inhouse ACTIVE Hywel Dda University Health Board Physician spectroscopy and exhanled volatile organic compounds in diagnosing and term conditions monitoring chronic obstructive pulmonary disease

Dr Atir Khan Consultant Physician, Hywel Dda University Health A comparative study of the effects of Liraglutide and Acarbose on Chronic Disease & long Inhouse CLOSED TO Hywel Dda University Health Board Diabetes & Endocrinology Board glycaemic control, weight and Health-Related Quality Of Life (HRQOL) in term conditions RECRUITMENT Overweight type 2 Diabetic patients on Oral Hypoglycaemic Agents (OHAs) + high doses of insulin

Dr Keir Lewis Senior Lecturer and Hywel Dda University Health In vitro neutrophil function from the blood and sputum of recurrent Chronic Disease & long Inhouse ACTIVE Mr Chris Tattersall, R&D Manager, Consultant Physician Board exacerbators and stable patients with moderate to severe Chronic term conditions Hywel Dda University Health Obstructive Pulmonary Disease (COPD), and healthy controls. Board, Withybush General Hospital, Fishguard Road, Haverfordwest, Pembrokeshire SA61 2PZ. Tel: 01437 773813, Email: [email protected] Dr James Melhorn F1 Training Doctor Hywel Dda University Health Memory Consolidation in the Obstructive Sleep Apnoea Hypopnoea Other Inhouse ACTIVE R&D Department Grant Hywel Dda University Health Board Board Syndrome

Sarah Jones Research Nurse Ty Geraint Does smoking status after being diagnosed with lung cancer influence Cancer Inhouse ACTIVE Pfizer grant award R&D, Withybush outcome? An observational cohort study alongside a randomised trial of different smoking cessation interventions

Appendix 1 Research and Development Data Hywel Ddda/PI's HDUHB Page 10 of 18 Appendix 1

Name of PI Designation PI - Add1 Research_Title Act Area Type of Trial Status Funding Sponsor Dr Brian Yate Consultant Anaesthetist Hywel Dda University Health A Pilot study to investigate the use of a standard spinal anaesthetic in Other Inhouse CLOSED TO Hywel Dda Local Health Board Board combination with a local anaesthetic infusion device (Braun 'On Q Pain RECRUITMENT Buster') as an alternative to thoracic epidural for analgaesia after open colorectal surgery within the framework of an ERAS protocol

Dr Daniel Clinical Research Fellow & Prince Philip Hospital Sleep disordered breathing & cardiac re-synchronisation therapy Coronary Heart Inhouse ACTIVE Hywel Dda University Health Board Swarmydass SpR in cardiology (Biventricular pacemaker) in patients with severe left ventricular failure Disease

Dr James Stroud Clinical Psychologist Hywel Dda University Health What works for me? A qualitative investigation into clients with borderline Mental Ill Heath Inhouse ACTIVE Hywel Dda University Health Board Board personality disorder views of psychotherapeutic treatment

Mr Jegadish Consultant Surgeon Hywel Dda University Health Randomised double blind controlled study, comparing the efficacy of Other Inhouse ACTIVE Hywel Dda University Health Board Mathias Board Transversus Abdominis Plane Blocks vs Local Infiltration following Laparoscopic Colorectal Surgery in Adults

Dr Atir Khan Consultant Physician, Hywel Dda University Health Safety, Tolerability and Effectiveness of Glucophage® SR in patients with Chronic Disease & long Inhouse CLOSED Dr Khan, Research Fund Hywel Dda University Health Board Diabetes & Endocrinology Board type – 2 Diabetes and Chronic Kidney Disease (eGFR 30 to term conditions 45mL/minute/1.73m2).

Dr Sam Rice Consultant Physician, Hywel Dda University Health Safety, Tolerability and Effectiveness of Glucophage® SR in patients with Chronic Disease & long Inhouse CLOSED Dr Khan, Research Fund Hywel Dda University Health Board Diabetes & Endocrinology Board type – 2 Diabetes and Chronic Kidney Disease (eGFR 30 to term conditions 45mL/minute/1.73m2).

Dr Granville Morris Consultant Physician Hywel Dda University Health Prevelence of Periodic Limb Movement in Dementia with Sundowning Services for Older Inhouse ACTIVE None Hywel Dda University Health Board Board People Dr Rav Harish Consultant in Pain & Hywel Dda University Health A prospective observational study for persistent low back pain comparing Other Inhouse ACTIVE Hywel Dda University Health Board Anaesthetics Board usual care using TENS machine vs Interactive Neurostimulation (InterX) device

Dr Robbie Ghosal Respiratory Consultant Hywel Dda University Health Fourier Transform Infra Red Spectroscopy on Pleural Fluid Cancer Inhouse ACTIVE Hywel Dda University Health Hywel Dda University Health Board Board Board Dr Keir Lewis Reader in Respiratory Hywel Dda University Health Does flexible home telemonitoring after hospital discharge for COPD Chronic Disease & long Inhouse ACTIVE United 4 Health Hywel Dda University Health Board Medicine & Consultant Board & Swansea University patients reduce hospital re-admission? A clustered, interventional trial. term conditions Physician College of Medicine Dr Sam Rice Consultant Diabetologist Hywel Dda University Health Does blood glucose Telemonitoring ™ and remotely delivered lifestyle Chronic Disease & long Inhouse ACTIVE NHS 24: The Information and Hywel Dda University Health Board Board advice improve self management in Type 2 Diabetes (T2DM)? A term conditions Communication Technologies prospective observational cohort study (U4H) Support Programme: CIP-ICT- PSP-.2012.3.5 Large scale deployment of telehealth services for chronic conditions management

Carol Thomas Lead Research Nurse Hywel Dda University Health Critical evaluation of protein and DNA biomarker detection for early Cancer Inhouse ACTIVE Board detection of lung cancer (WCRN SW Wales Trials portfolio - Medlung - Early detection of lung cancer: metabolic markers for high risk screening)

Rachel Roberts Researcher & Portfolio Hywel Dda University Health Comparing 3 ways of validating smoking status in a real life setting: Other Inhouse ACTIVE No R&D Funding - Respiratory Hywel Dda University Health Board Research Coordinator Board exhaled carbon monoxide, slaivary cotinine and urinary cotinine Research Fund

Chris Tattersall R&D Manager & Hywel Dda University Health Accuracy of staff in estimating fluid volumes in elderly care - A pilot study. Services for Older Inhouse ACTIVE n/a Hywel Dda University Health Board Researcher Board People Dr Girish K Patel Consultant Dermatologist Hywel Dda University Health Elucidating the transformational role of ß human papillomarvirus early Inhouse ACTIVE NISCHR Fellowship Award Hywel Dda University Health Board Board region genes in skin of organ transplant recipients and healthy individuals

Carol Thomas Lead Research Nurse Clinical Trials Office Does smoking status after being diagnosed with lung cancer influence Cancer Inhouse PROPOSED R&D, Withybush outcome? An observational cohort study alongside a randomised trial of different smoking cessation interventions

Sarah Rees Health Services Mynydd Mawr Hospital Does home telemonitoring reduce healthcare utilisation in patients with Chronic Disease & long Inhouse MSc/PhD ACTIVE PhD Hywel Dda University Health Board Researcher chronic obstructive pulmonary disease (COPD) who have had multiple term conditions hospital admissions?

Caroline Williams Nursing Development Hywel Dda University Health The Role of Facilitation in Enabling Work-Based Learning Other Inhouse MSc/PhD ACTIVE R&D Grant awarded Mr Nick Curry, University of Ulster, Facilitator Board Shore Road, Newtownabbey, Co. Antrim BT37 0QB. [email protected]

Mr Ezesomaga U J Charge Nurse Hywel Dda University Health Staff Nurses' Involvement in Discharge Planning Other Inhouse MSc/PhD ACTIVE University of Essex University of Essex Ejimogu Board Mr Jonathan Orthotist Gate Cottage Foot length ratios as a predictor for foot pathology: A comparative study Other Inhouse MSc/PhD ACTIVE none Hywel Dda University Health Board Tebbutt of pathological footprint data

Miss Najma Sultana Assistant Psychologist Hywel Dda University Health A Carer's Journey: a comparative study of two populations Mental Ill Heath Inhouse MSc/PhD ACTIVE University of Birmingham University of Birmingham Board Anka Meess Biomedical Student 2 Charles Road Introduction of Intravenous Infusion pumps for Platelet Transfusion on Other Inhouse MSc/PhD ACTIVE Ulster University Jointly sponsored by Ulster Chemotherapy patients to replace Gravity Transfusion in a rural General University & Hywel Dda University Hospital Health Board

Rachel Roberts Portfolio & Research Hywel Dda University Health Evaluation of Smoking Cessation Strategies in Lung Cancer Patients: Cancer Inhouse MSc/PhD ACTIVE Swansea University Hywel Dda University Health Board Centre Coordinator Board Developing a Tailored and Specialist Service

Appendix 1 Research and Development Data Hywel Ddda/PI's HDUHB Page 11 of 18 Appendix 1

Name of PI Designation PI - Add1 Research_Title Act Area Type of Trial Status Funding Sponsor Kelly Reed 5 Ash Tree Close Sardis Physical activity in Palliative Breast Cancer Patients Cancer Inhouse MSc/PhD ACTIVE University of Dundee

Ruth Graham Speciality Doctor General Hywel Dda University Health Gastrointestinal disease - effects of surgery and chemotherapy on QOL Cancer Inhouse MSc/PhD ACTIVE No external funding Swansea University Surgery Board Enzo DiBattista Dietician Dietetics Department Prosiect Sir Gar (The Carmarthenshire Project) Other Service Eval/Audit/Non ACTIVE Research

Miss Amie-Louise PhD Student Psychology Dept Exploration of existing telephone helplines and related services for people Other Service Eval/Audit/Non ACTIVE National Institute for Social Louise Fielding, Cardiff Prior with Eating Disorders Research Care and Health Research Metropolitan University, Western Avenue, Cardiff CF5 2YB. Email: [email protected] Tel: 02920 416456. NHS Indemnity applies

Dr Sally Williams Consultant Pathology Dept Wales Cancer Bank Cancer Tissue Banking ACTIVE wales cancer bank Histopathologist Dr Keir Lewis Consultant Respiratory Respiratory Centre Hywel Dda Genetics of Smoking and Smoking Cessation Other Tissue Banking ACTIVE Swansea University Physician Dr Graham Consultant Psychiatrist & MHLD Wales Mental Health Network: Research Tissue Bank Mental Ill Heath Tissue Banking ACTIVE Human Tissue Authority storage O'Connor AMD MHLD licence no: 12422. Establishment responsible for managing the bank - School of Medicine, Cardiff University

Dr Girish K Patel Consultant Dermatologist Hywel Dda University Health Board

Appendix 1 Research and Development Data Hywel Ddda/PI's HDUHB Page 12 of 18 CI- Name CI - Designation CI - Add1 Research_Title Status primary Funding Sponsor Professor Kamlesh Professor of Primary Care Diabetes Research Centre DISCOVERing Treatment Reality of Type 2 PROPOSED Other AstraZeneca AstraZeneca Khunti Diabetes and Vascular Diabetes in Real World Settings Medicine Dr Niall Furlong Consultant Diabetologist St Helens and Knowsley Efficacy and safety of semaglutide once-weekly ACTIVE Chronic Disease & long Novo Nordisk Novo Nordisk - Christina Ronsholt, International Teaching Hospitals NHS Trust versus placebo in drug-naïve subjects with type 2 term conditions Trial Manager, Novo Nordisk A/S, Novo Alle, diabetes Denmark DK-2880. email: [email protected] Rhys Thatcher Senior Lecturer Sports and Health Sciences The role of Vitamin D and physical activity in type ACTIVE Other R&D Grant £6,249 - awarded March Aberystwyth University, c/o Professor David Dept 2 diabetes 2011 Lavallee, Department of Sport and Exercise Science, Carwyn James Building, Aberystwyth University, Aberystwyth SY23 3FD Tel: 01970 628559 Email: [email protected] Christopher Hawkey National Coordinating University of Nottingham Helicobacter eradication to prevent ulcer bleeding PROPOSED Chronic Disease & long NIHR Health Technology Assessment University of Nottingham Investigator - HEAT Trial in aspirin users; a large simple randomised term conditions (HTA) Programme, & Modepharma, controlled trial Commercial Funder

Professor Munir NHS Chair of Dept of Pharmacology and Pharmacogenics of Statin-Induced Muscle ACTIVE Coronary Heart Disease MRC University of Liverpool Pirmohamed Pharmacogenics Theraputics Toxicity. Exploration using the UK General Practice Research Database

Dr Steven Julious Reader in Medical University of Sheffield Preventing and Lessening Exacerbations of ACTIVE Services for Children & NIHR Health Technology Assessment Sheffield Health & Social Care Foundation Trust Statistics Asthma in Schoolage children Associated with a Young People New Term Dr Kate Fletcher Lead and Project Manager - University of Birmingham Long Term follow-up of the Birmingham Atrial ACTIVE Services for Older People NIHR National School for Primary University of Birmingham BAFTA Fibrillation Treatment of the Aged Study: a Care Research randomised controlled trial of warfarin versus aspirin for stroke prevention in the management of atrial fibrillation in the elderly (aged >75) primary care polulation

Dr Christopher Lynch Senior Lecturer and Hon. Cardiff University Reasons for placement and replacement of ACTIVE Wales School for Primary Care Cardiff University Consultant in Restorative crowns v1.0 Research Dentistry Mrs Caroline O'Leary Medical Statistician CSD MR UK UK Retrospective database analysis evaluation ACTIVE Other Commercially funded - Pfizer Cegedim Medical Research UK hormone therapy treatment patterns in women ([email protected]) aged >45 years

Dr Majid Artus NIHR Clinical Lecturer in Keele University Management of shoulder pain by UK General ACTIVE Other Arthritis Research UK Centre of Keele University General Practice Practitioners (GPs): A National Survey Escellence Grant

Dr David Ansell Research Manager CSD MR UK Assessment of the safety of Long Acting Beta PROPOSED Chronic Disease & long European Commission - FP7-HEALTH- Universite Claude Bernard Lyon 1 (UK Legal Agonists (LABAs) in Asthma in Routine Care by term conditions 2011-single-stage GA nº282593 Representative - University of Nottingham combining healthcare databases and direct patient follow up

Dr David Ansell Research Manager CSD MR UK Assessment of the safety of Long Acting Beta PROPOSED Chronic Disease & long European Commission - FP7-HEALTH- Universite Claude Bernard Lyon 1 (UK Legal Agonists (LABAs) in Asthma in Routine Care by term conditions 2011-single-stage GA nº282593 Representative - University of Nottingham combining healthcare databases and direct patient follow up

Professor Paul Little Professor of Primary Care University of Southampton CANcer DIagnosis Decision rules ACTIVE Cancer NIHR School for Primary Care University of Southampton Research Mr Matthew Bown Senior Lecturer in Vascular University of Leicester The United Kingdom Aneurysm Growth Study ACTIVE Other British Heart Foundation University of Leicester Surgery Professor Martin Professor of Public Health Kings College London Electronic intervention to reduce antibiotic ACTIVE Other NIHR Health Technology Assessment Kings College London Gulliford prescribing Programme

Professor Clive Ballard Professor of Age-Related Kings College London Platform for Research Online to Investigate PROPOSED Mental Ill Heath NIHR Kings College London, co-sponsored by South Diseases Genetics and Cognition in Ageing : Understanding London and Maudsley NHS Foundation Trust the impact of genetic and other risk factors on cognition in a cohort of people over 50

Professor Thomas Director of University of Dundee / NHS Treatment In the Morning versus Evening: Day PROPOSED Other British Heart Foundation University of Dundee MacDonald MEMO/Professor of Clinical Tayside time Intervention at Night: Evaluation of Major Pharmacology and Outcomes and Vascular Events Pharmacoepidemiology

Delyth Lewis Telemedicine Manager Hywel Dda University Health Operational Research Fellowship projects: ACTIVE Other Board Proposed Demonstration Project: NHS Telemedicine - GP Practices

Appendix 1 Research and Development Data Hywel Ddda/PRIMARY CARE RESEARCH Page 13 of 18 Type of Trial Research_Title CI- Name CI - Add1 Funding Sponsor

External MSc/PhD A study of peri-ictal behavioural changes in adults with learning Professor Mike Kerr Bromorgannwg NHS disabilities External MSc/PhD The role of Vitamin D and physical activity in type 2 diabetes Rhys Thatcher Sports and Health Sciences Dept R&D Grant £6,249 - awarded March Aberystwyth University, c/o Professor David Lavallee, Department 2011 of Sport and Exercise Science, Carwyn James Building, Aberystwyth University, Aberystwyth External MSc/PhD HEalth in the workplace And Lifestyle THerapy Dr Jeffrey Stephens Swansea University & ABM Swansea Uni & ABMU Joint sponsors? University Health Board External MSc/PhD Intracranial Haemorrhage in thrombocytopenic haematology patients Dr Lise Estcourt NHSBT, Level 2 National Health Service Blood and Professor Marion Scott, National R&D Manager, NHSBT Transplant External MSc/PhD Homicide by patients with schizophrenia: a case control study Professor Jenny Shaw Lancashire Care NHS Trust & The National Patient Safety Agency University of Manchester University of Manchester External MSc/PhD Development and validation of Short form of Crohn’s and Colitis Dr Laith Alrubaiy College of Medicine Swansea University internal funding Swansea University Questionnaire and Swansea Inflammatory bowel (CCQ & SICSI Questionnaires)

External MSc/PhD The development of a measure of barriers to exercise for individuals with Mrs Alison Connaughton University of Wales Trinity St David Ceri Jones, Deputy Director of Research & Innovation, Swansea type 2 diabetes University

External MSc/PhD The development of a measure of barriers to exercise for individuals with Mrs Alison Connaughton University of Wales Trinity St David Ceri Jones, Deputy Director of Research & Innovation, Swansea type 2 diabetes University

External MSc/PhD Surgical and large bore pleural procedures in malignant pleural Dr Nick Maskell North Bristol NHS Trust North Bristol NHS Trust - [email protected] Mesothelioma and Radiotherapy Trial (SMART) - A randomised controlled trial evaluating whether prophylactic radiotherapy reduces the incidence of procedure tract metastases External MSc/PhD An exploration of health visitors' understanding of the principle of Professor Joy Merrell Swansea University Swansea University Swansea University 'influencing policies affecting health' and it's realisation in practice

External MSc/PhD Perceptions of job competency & stress levels of nurses caring for Dr Ceri Phelps Centre for Psychology & Counselling Swansea Metropolitan University Swansea Metropolitan University patients with Dementia

External MSc/PhD COMparing treatment options for ProstAte canceR: Evaluating Patient Professor Mark Emberton University College London Medical Research Council (MRC) University College London Preferences for the Treatment of Localised Prostate Cancer - A Discrete Choice Experiment

External MSc/PhD Family carers’ perceptions of how their views and opinions were received Mr Neil James University of Glamorgan Glamorgan University Glamorgan University by professionals during their relative’s stay in an Assessment and Treatment Unit - An interpretative phenomenological study

External MSc/PhD Functional Assessment in early Breast cancer in Older Patients Dr Alistair Ring Brighton and Sussex County Roche Products Brighton & Sussex University Hospitals NHS Trust Hospitals NHS Trust External MSc/PhD REVISE - Diabesity Study: Randomisation to Endoluminal liner Bob Ryder Sandwell & West Birmingham Asssociation of British Clinical Sandwell & West Birmingham Hospitals NHS Trust (Endobarrier) alone Versus with Incretin analogue (Liraglutide) in Hospitals NHS Trust Diabetologists SustainEd Diabesity

External MSc/PhD Surgical and large bore pleural procedures in malignant pleural Dr Nick Maskell North Bristol NHS Trust North Bristol NHS Trust - [email protected] Mesothelioma and Radiotherapy Trial (SMART) - A randomised controlled trial evaluating whether prophylactic radiotherapy reduces the incidence of procedure tract metastases External MSc/PhD Developing online psychoeducation for adolescent depression Dr Rhys Bevan Jones Cardiff University, School of Cardiff University, School of Cardiff University, lead NHS Site is Cwm Taf Health Board (see Medicine Medicine status notes) External MSc/PhD Functional Assessment in early Breast cancer in Older Patients Dr Alistair Ring Brighton and Sussex County Roche Products Brighton & Sussex University Hospitals NHS Trust Hospitals NHS Trust External MSc/PhD Exploring the experiences of palliative care patients and informal carers Mr Joseph Keenan Psychology Dept Aberystwyth University Aberystwyth University use of home-based telehealth equipment

External MSc/PhD The Cultural Representation of Older People: Cultural Ageism and the Mr Simon Read Cardiff School of Social Sciences Economic and Social Research Cardiff University Health and Social Care Sector Council

External MSc/PhD Management of lifestyle changes recommended after first diagnosis with Martine Robson Aberystwyth University Aberystwyth University Aberystwyth University coronary heart disease by people with and without long-term partners

External MSc/PhD Feeding and Autoimmunity in Down's syndrome Evaluation Study Dr Georgina Williams Bristol Nutrition BRU University of Bristol The Bristol Nutrition BRU

External MSc/PhD An observational study to investigate the ability of Emergency Nurse Dr Jayne Cutter Swansea University Swansea University Swansea University Practitioners (ENPs) to interpret appendicular x-rays of children less than five years of age following an education programme

External MSc/PhD Investigation of the factors (visual functions and/or device parameters) Areej PhD Student Cardiff University Cardiff University that affect reading performance in people with visual impairment who are using pocket and portable electronic low vision aids (PELVAs)

External MSc/PhD The role of mindfulness and coping on burnout and occupational stress Miss Sarah Kriakous North Wales Clinical Psychology Bangor University Bangor University amongst health professinals employed within forensic inpatient settings Programme

Appendix 1 Research and Development Data Hywel Ddda/EXTERNAL MScPhD Page 14 of 18 External MSc/PhD Diagnostic Journeys in Myeloma: Why are they so long and what may Mrs Tania Seale Bangor University Tenovus Cancer Charity - PhD Bangor University facilitate earlier diagnosis? studentship grant

External MSc/PhD Diagnostic Journeys in Myeloma: Why are they so long and what may Mrs Tania Seale Bangor University Tenovus Cancer Charity - PhD Bangor University facilitate earlier diagnosis? studentship grant

External MSc/PhD Assessing implementation of evidence based practices in Early Ms Joanna White Swansea University Swansea University Swansea University Intervention teams in Mental Health Services

External MSc/PhD Diagnostic Journeys in Myeloma: Why are they so long and what may Mrs Tania Seale Bangor University Tenovus Cancer Charity - PhD Bangor University facilitate earlier diagnosis? studentship grant

External MSc/PhD Study of substance misuse treatment providers Dr Catriona Matheson University of Aberdeen University of Aberdeen University of Aberdeen External MSc/PhD The experiecnes of Behaviour Clinical Specialists of involving services Miss Bethany Kruger Aneurin Bevan Local Health Board users in the development of their PBS plans. (PBS plans are Positive Behaviour Support plans. PBS plans reflect the healthcare needs of the individual and strategies of how best to support the individual).

External MSc/PhD The role of body image and body image investment in mastectomy and Helen Le Vesconte breast reconstruction.

Appendix 1 Research and Development Data Hywel Ddda/EXTERNAL MScPhD Page 15 of 18 Type of Trial CI- Name Research_Title Funding Sponsor Inhouse MSc/PhD Dr Keir Lewis Does home telemonitoring reduce healthcare utilisation in PhD Hywel Dda University Health Board patients with chronic obstructive pulmonary disease (COPD) who have had multiple hospital admissions?

Inhouse MSc/PhD Professor Brendan McCormack The Role of Facilitation in Enabling Work-Based Learning R&D Grant awarded Mr Nick Curry, University of Ulster, Shore Road, Newtownabbey, Co. Antrim BT37 0QB. [email protected] Inhouse MSc/PhD Mr Ezesomaga U J Ejimogu Staff Nurses' Involvement in Discharge Planning University of Essex University of Essex

Inhouse MSc/PhD Professor Nachiappan Chockalingam Foot length ratios as a predictor for foot pathology: A none Hywel Dda University Health Board comparative study of pathological footprint data

Inhouse MSc/PhD Dr Michael Larkin A Carer's Journey: a comparative study of two populations University of Birmingham University of Birmingham

Inhouse MSc/PhD Ted Allen Introduction of Intravenous Infusion pumps for Platelet Ulster University Jointly sponsored by Ulster University & Hywel Transfusion on Chemotherapy patients to replace Gravity Dda University Health Board Transfusion in a rural General Hospital

Inhouse MSc/PhD Rachel Roberts Evaluation of Smoking Cessation Strategies in Lung Cancer Swansea University Hywel Dda University Health Board Patients: Developing a Tailored and Specialist Service

Inhouse MSc/PhD Ms Antonia Lannie Physical activity in Palliative Breast Cancer Patients University of Dundee

Inhouse MSc/PhD Dr Keir Lewis A Pilot Study to examine the Effect of Acute Exercise on KESS £10,130, Aberystwyth Hywel Dda University Health Board Neutrophil Function in patients with COPD University

Inhouse MSc/PhD Joy Singh Gastrointestinal disease - effects of surgery and No external funding Swansea University chemotherapy on QOL

Appendix 1 Research and Development Data Hywel Ddda/INTERNAL MScPhD's Page 16 of 18 INDUSTRY COLLABORATION HEI COLLABORATIONS NHS COLLABORATIONS ALLERGAN Inc. Aberystwyth University North Bristol NHS Trust Abbott Laboratories Ltd Swansea University Cwm Taf Health Board Sanofi University of Manchester Brighton & Sussex University Hospitals NHS Trust Medpace Ltd Cardiff University Sandwell & West Birmingham Hospitals NHS Trust Daiichi-Sankyo University of Wales Trinity St David Cambridge University Hospitals NHS Foundation Trust Novartis Pharmaceuticals UK Ltd University College London Plymouth Hospital Trust Bristol-Myers Squibb Bangor University Institute for Cancer Research & Royal Marsden NHS Foundation Trust Chiesi Farmaceutici S.p.A University of Aberdeen European Organisation for Research and Treatment of Cancer (EORTC) Daiichi Sankyo Development Ltd University of Cambridge University Hospitals of Leicester NHS Trust Janssen-Cilag International NV - CRO: Quintilles Ltd Imperial College London Central Manchester University Hospitals NHS Trust (CMFT) Orion Corporation Orion Pharma | UK Lead - Icon Clinical Oxford University Imperial College of Science Technology and Medicine Reserach UK Ltd Glaxo Smithkline University of Glasgow University of Manchester & University Hospital of South Manchester Takeda Pharma University of Birmingham Guy's & St Thomas' NHS Foundation Trust Mundipharma Research Ltd University of Leeds Velindre NHS Trust Alcon Eye Care UK Ltd University of Edinburgh University of Warwick, Co-sponsored by University Hospitals Coventry & Warwickshire AstraZeneca University of Southampton Royal United Hospital Bath NHS Trust Novo Nordisk Newcastle University ICR & Royal Marsden NHS Foundation Trust & Institute for Cancer Research Eli Lilly & Company Ltd University of Liverpool Princess Alexandra Hospital NHS Trust Novo Nordisk AS Queen Mary University of London Guy's & St Thomas' NHS Foundation Trust Cancer Research UK University of Hereforshire Sheffield Health and Social Care Foundation Trust NCIC Clinical Trials Unit University of Bath Kings College London Medical Research Council (MRC) Keele University University College London Hospitals NHS Foundation Trust Institute of Cancer Research ECMC Universite Claude Bernard Lyon 1 Barts Health NHS Trust The Institute for Cancer Research University of Dundee UWIC University of Essex University of Essex Wales Cancer Bank

Appendix 1 Research and Development Data Hywel Ddda/COLLABORATIONS Page 17 of 18 SUMMARY MAIN AREAS OF RESEARCH

Respiratory Diabetes Dermatology Pain Management & Anaesthetics Haematology Breast Cancer Urology Cardiology Colorectal Sugery Mental Health

CI's in HYWEL DDA 14

Pis in HYWEL DDA 131

PRIMARY CARE RESEARCH STUDIES 18

INTERNAL MSc/PhD's 10

EXTERNAL MSc/PhD's 32

Appendix 1 Research and Development Data Hywel Ddda/SUMMARY Page 18 of 18