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Appendix 1 Research and Development Data Hywel Ddda.Xlsx Appendix 1 CI- Name CI Research_Title Status Sponsor Dr Girish K Patel Consultant Dermatologist & NISCHR Research The isolation and characterisation of normal Dermatology ACTIVE Cardiff University Fellow human keratinocyte and non-melanoma skin cancer stem cells. Dr Keir Lewis Respiratory Consultant Critical evaluation of protein and DNA biomarker Respiratory ACTIVE Hywel Dda University Health Board detection for early detection of lung cancer (WCRN SW Wales Trials portfolio - Medlung - Early detection of lung cancer: metabolic markers for high risk screening). Dr Keir Lewis Respiratory Consultant Does smoking status after being diagnosed with Respiratory ACTIVE R&D, Withybush lung cancer influence outcome? An observational cohort study alongside a randomised trial of different smoking cessation interventions. Dr Keir Lewis Consultant Respiratory Physician Testing Sputum Rheology, sputum fourier Respiratory ACTIVE Hywel Dda University Health Board transformed infrared spectroscopy and exhanled volatile organic compounds in diagnosing and monitoring chronic obstructive pulmonary disease. Dr Atir Khan Consultant Physician, Diabetes & Endocrinology A comparative study of the effects of Liraglutide Diabetes CLOSED TO Hywel Dda University Health Board and Acarbose on glycaemic control, weight and RECRUITMENT Health-Related Quality Of Life (HRQOL) in Overweight type 2 Diabetic patients on Oral Hypoglycaemic Agents (OHAs) + high doses of insulin. Dr Keir Lewis Senior Lecturer and Consultant Physician In vitro neutrophil function from the blood and Respiratory ACTIVE Mr Chris Tattersall, R&D Manager, Hywel Dda University sputum of recurrent exacerbators and stable Health Board, Withybush General Hospital, Fishguard Road, patients with moderate to severe Chronic Haverfordwest, Pembrokeshire SA61 2PZ. Tel: 01437 Obstructive Pulmonary Disease (COPD), and 773813, Email: [email protected] healthy controls. Dr Keir Lewis Respiratory Consultant Memory Consolidation in the Obstructive Sleep Respiratory ACTIVE Hywel Dda University Health Board Apnoea Hypopnoea Syndrome. Dr Brian Yate Consultant Anaesthetist A Pilot study to investigate the use of a standard Anaesthetics CLOSED TO Hywel Dda Local Health Board spinal anaesthetic in combination with a local RECRUITMENT anaesthetic infusion device (Braun 'On Q Pain Buster') as an alternative to thoracic epidural for analgaesia after open colorectal surgery within the framework of an ERAS protocol Dr Keir Lewis Respiratory Consultant Sleep disordered breathing & cardiac re- Respiratory ACTIVE Hywel Dda University Health Board synchronisation therapy (Biventricular pacemaker) in patients with severe left ventricular failure. Dr James Stroud Clinical Psychologist What works for me? A qualitative investigation Mental Health ACTIVE Hywel Dda University Health Board into clients with borderline personality disorder views of psychotherapeutic treatment. Mr Jegadish Mathias Consultant Surgeon Randomised double blind controlled study, ACTIVE Hywel Dda University Health Board comparing the efficacy of Transversus Abdominis Plane Blocks vs Local Infiltration following Laparoscopic Colorectal Surgery in Adults. Dr Atir Khan Consultant Physician, Diabetes & Endocrinology Safety, Tolerability and Effectiveness of Diabetes CLOSED Hywel Dda University Health Board Glucophage® SR in patients with type – 2 Diabetes and Chronic Kidney Disease (eGFR 30 to 45mL/minute/1.73m2). Dr Granville Morris Consultant Physician Prevelence of Periodic Limb Movement in Mental Health ACTIVE Hywel Dda University Health Board Dementia with Sundowning. Appendix 1 Research and Development Data Hywel Ddda/CI's HDUHB Page 1 of 18 Appendix 1 CI- Name CI Research_Title Status Sponsor Dr Susmita Oomman Consultant in Pain & Anaesthetics A prospective observational study for persistent Anaesthetics ACTIVE Hywel Dda University Health Board low back pain comparing usual care using TENS machine vs Interactive Neurostimulation (InterX) device. Dr Keir Lewis Reader in Respiratory Medicine & Consultant Does flexible home telemonitoring after hospital Respiratory ACTIVE Hywel Dda University Health Board Physician discharge for COPD patients reduce hospital re- admission? A clustered, interventional trial. Dr Sam Rice Consultant Diabetologist Does blood glucose Telemonitoring ™ and Diabetes ACTIVE Hywel Dda University Health Board remotely delivered lifestyle advice improve self management in Type 2 Diabetes (T2DM)? A prospective observational cohort study (U4H). Dr Keir Lewis Respiratory Consultant Critical evaluation of protein and DNA biomarker Respiratory ACTIVE detection for early detection of lung cancer (WCRN SW Wales Trials portfolio - Medlung - Early detection of lung cancer: metabolic markers for high risk screening). Dr Leir Lewis Reader in Respiratory Medicine & Consultant Comparing 3 ways of validating smoking status Respiratory ACTIVE Hywel Dda University Health Board Physician in a real life setting: exhaled carbon monoxide, slaivary cotinine and urinary cotinine. Chris Tattersall R&D Manager & Researcher Accuracy of staff in estimating fluid volumes in ACTIVE Hywel Dda University Health Board elderly care - A pilot study. Dr Sam Rice Consultant Diabetologist An Evaluation of a Diabetes Self-Management Diabetes ACTIVE Hywel Dda University Health Board Program developed by Standford University: A Randomised Controlled Trial. Dr Girish K Patel Consultant Dermatologist Elucidating the transformational role of ß human Diabetes ACTIVE Hywel Dda University Health Board papillomarvirus early region genes in skin of organ transplant recipients and healthy individuals. Dr Keir Lewis Consultant Respiratory Physician Does home telemonitoring reduce healthcare Respiratory ACTIVE Hywel Dda University Health Board utilisation in patients with chronic obstructive pulmonary disease (COPD) who have had multiple hospital admissions? Mr Ezesomaga U J Ejimogu Charge Nurse Staff Nurses' Involvement in Discharge Planning. ACTIVE University of Essex Rachel Roberts Portfolio & Research Centre Coordinator Evaluation of Smoking Cessation Strategies in Respiratory ACTIVE Hywel Dda University Health Board Lung Cancer Patients: Developing a Tailored and Specialist Service. Dr Keir Lewis Reader in Respiratory Medicine & Consultant A Pilot Study to examine the Effect of Acute Respiratory ACTIVE Hywel Dda University Health Board Physician Exercise on Neutrophil Function in patients with COPD. Joy Singh Consultant Colorectal Surgeon Gastrointestinal disease - effects of surgery and ACTIVE Swansea University chemotherapy on QOL. Delyth Lewis Telemedicine Manager Operational Research Fellowship projects: ACTIVE Proposed Demonstration Project: NHS Telemedicine - Teledermatology. Delyth Lewis Telemedicine Manager Operational Research Fellowship projects: ACTIVE Proposed Demonstration Project: NHS Telemedicine - GP Practices. Appendix 1 Research and Development Data Hywel Ddda/CI's HDUHB Page 2 of 18 Appendix 1 Name of PI Designation PI - Add1 Research_Title Act Area Type of Trial Status Funding Sponsor Dr Susmita Consultant in Pain Hywel Dda University Health BOTOX Prophylaxis in Chronic Migraine Version 1: Postauthorization Chronic Disease & long External Commercial CLOSED TO Allergan Inc ALLERGAN Inc. Oomman Management & Board Observational Study term conditions CTimp RECRUITMENT Anaesthetics Dr Atir Khan Consultant Physician, Hywel Dda University Health A Randomised, double-blind, placebo-controlled, parallel-group, Coronary Heart External Commercial CLOSED TO Sanofi Aventis Contact: Mr Myles Callaghan, Diabetes & Endocrinology Board multicentre study to evaluate cardiovascular outcomes during treatment Disease CTimp RECRUITMENT Clinical Research Unit, Sanofi with Lixisenatide in Type 2 diabetic patients after an Acute Coronary Aventis, One Onslow Street, Syndrome (EFC11319). (DRN345 - Commercial Portfolio adopted study) Guildford GU1 4YS. Dr Jayne Evans Consultant Prince Philip Hospital Multicountry, cross sectionAL study to determine patient specIfic and Chronic Disease & long External Commercial CLOSED TO Abbott Laboratories Ltd Abbott Laboratories Ltd Rheumatologist General beliefs towards medicatioN and their treatment compliance to term conditions CTimp RECRUITMENT selected systemic therapies in chronic inflammatory diseases (IMID) Dr Atir Khan Consultant Physician Hywel Dda University Health AVE0010 – EFC12626 (Lixisenatide) version 1.0: A randomized, open- Chronic Disease & long External Commercial CLOSED TO Sanofi Sanofi Board label, active-controlled, 3-arm parallel-group, 26-week study comparing term conditions CTimp RECRUITMENT the efficacy and safety of lixisenatide to that of insulin glulisine once daily and insulin glulisine three times daily in patients with Type 2 diabetes insufficiently controlled with insulin glargine with or without metformin. Dr Nuha Haboubi Consultant in Chemical Hywel Dda University Health A Randomised, double-blind study of the efficacy and safety of REGN727 Coronary Heart External Commercial CLOSED TO Medpace Ltd Medpace Ltd Pathology Board added-on to Atovastatin versus Ezetimibe, added-on to Atorvastatin Disease Ctimp RECRUITMENT versus Atorvastatin Dose Increase, versus Switch to Rosuvastatin in Patients who are not controlled on Atorvastatin. Dr Jon Holmes Consultant Haematologist Hywel Dda University Health Prevention of Thromboembolic Events - European Registry in Venous Other External Commercial CLOSED TO Daiichi-Sankyo Daiichi-Sankyo Board Thromboembolism CTimp RECRUITMENT Dr Debbie Shipley Consultant
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